 Amino Acid Substitution
"Amino Acid Substitution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
| Descriptor ID |
D019943
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| MeSH Number(s) |
E05.393.420.601.035 G05.355.600.109
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| Concept/Terms |
Amino Acid Substitution- Amino Acid Substitution
- Amino Acid Substitutions
- Substitution, Amino Acid
- Substitutions, Amino Acid
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Below are MeSH descriptors whose meaning is more general than "Amino Acid Substitution".
Below are MeSH descriptors whose meaning is more specific than "Amino Acid Substitution".
This graph shows the total number of publications written about "Amino Acid Substitution" by people in this website by year, and whether "Amino Acid Substitution" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 2 | 2 | | 1999 | 1 | 2 | 3 | | 2000 | 1 | 4 | 5 | | 2001 | 1 | 3 | 4 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 6 | 6 | | 2004 | 0 | 4 | 4 | | 2005 | 0 | 8 | 8 | | 2006 | 0 | 8 | 8 | | 2007 | 1 | 8 | 9 | | 2008 | 1 | 7 | 8 | | 2009 | 1 | 3 | 4 | | 2010 | 0 | 3 | 3 | | 2011 | 1 | 2 | 3 | | 2012 | 0 | 5 | 5 | | 2013 | 0 | 8 | 8 | | 2014 | 0 | 3 | 3 | | 2016 | 0 | 6 | 6 | | 2017 | 0 | 5 | 5 | | 2018 | 0 | 2 | 2 | | 2019 | 0 | 2 | 2 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Amino Acid Substitution" by people in Profiles.
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Torralba-Raga L, Tesi B, Chiang SCC, Schlums H, Nordenskjöld M, Horne A, Henter JI, Meeths M, Abdelhaleem M, Weitzman S, Bryceson Y. Diagnostic challenges for a novel SH2D1A mutation associated with X-linked lymphoproliferative disease. Pediatr Blood Cancer. 2020 04; 67(4):e28184.
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Piñas GE, Parkinson JS. Identification of a Kinase-Active CheA Conformation in Escherichia coli Chemoreceptor Signaling Complexes. J Bacteriol. 2019 12 01; 201(23).
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Clark ST, Sinha U, Zhang Y, Wang PW, Donaldson SL, Coburn B, Waters VJ, Yau YCW, Tullis DE, Guttman DS, Hwang DM. Penicillin-binding protein 3 is a common adaptive target among Pseudomonas aeruginosa isolates from adult cystic fibrosis patients treated with ß-lactams. Int J Antimicrob Agents. 2019 May; 53(5):620-628.
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Cooper CJ, Dutta NT, Martin CE, Piscione TD, Thorner PS, Jones N. Characterization of a novel disease-associated mutation within NPHS1 and its effects on nephrin phosphorylation and signaling. PLoS One. 2018; 13(9):e0203905.
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Amayiri N, Swaidan M, Al-Hussaini M, Halalsheh H, Al-Nassan A, Musharbash A, Tabori U, Hawkins C, Bouffet E. Sustained Response to Targeted Therapy in a Patient With Disseminated Anaplastic Pleomorphic Xanthoastrocytoma. J Pediatr Hematol Oncol. 2018 08; 40(6):478-482.
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Chang YH, Stone TA, Chin S, Glibowicka M, Bear CE, Deber CM. Structural effects of extracellular loop mutations in CFTR helical hairpins. Biochim Biophys Acta Biomembr. 2018 May; 1860(5):1092-1098.
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Hogarth KA, Costford SR, Yoon G, Sondheimer N, Maynes JT. DNM1L Variant Alters Baseline Mitochondrial Function and Response to Stress in a Patient with Severe Neurological Dysfunction. Biochem Genet. 2018 Apr; 56(1-2):56-77.
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Vernon RM, Chong PA, Lin H, Yang Z, Zhou Q, Aleksandrov AA, Dawson JE, Riordan JR, Brouillette CG, Thibodeau PH, Forman-Kay JD. Stabilization of a nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator yields insight into disease-causing mutations. J Biol Chem. 2017 08 25; 292(34):14147-14164.
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Rafiq MA, Chaudhry A, Care M, Spears DA, Morel CF, Hamilton RM. Whole exome sequencing identified 1 base pair novel deletion in BCL2-associated athanogene 3 (BAG3) gene associated with severe dilated cardiomyopathy (DCM) requiring heart transplant in multiple family members. . 2017 Mar; 173(3):699-705.
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Lai RZ, Gosink KK, Parkinson JS. Signaling Consequences of Structural Lesions that Alter the Stability of Chemoreceptor Trimers of Dimers. J Mol Biol. 2017 03 24; 429(6):823-835.
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