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Last name

Ameet Sengar

TitleSenior Research Associate
InstitutionThe Hospital for Sick Children
DepartmentNeurosciences & Mental Health
Address555 University Avenue
Toronto ON M5G 1X8
ORCID ORCID Icon0000-0002-6328-1108 Additional info
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    Collapse Biography 
    Collapse education and training
    SickKids Hospital2017miniMBA
    SickKids Hospital2015Incidental Leadership
    SickKids Hospital2012Scientist Knowledge Translation
    University of Toronto, TorontoPhD08/2004Molecular and Medical Genetics
    University of Calgary, CalgaryMSc04/1997Biochemistry and Molecular Biology
    University of Ottawa, OttawaBSc04/1994Biology/Biotechnology
    Collapse awards and honors
    2015President’s Award, “Empowering People and Innovating to Drive Impact”, SickKids Hospital

    Collapse Overview 
    Collapse overview

    - Twenty years of biomedical research experience in project design, implementation, budgeting, grant writing, knowledge translation and mentoring
    - Developing relationships and networks with scientists and high level managers at Toronto Hospitals, University of Toronto, local biotechs and venture capitals
    - Implementing new and improved research training centre (RTC) programs to enable and empower people

    Committee Memberships:

    2018 – Co-Chair, Spotlight Seminar Series
    2012 – Member, Research Associate Advisory Committee
    2016 – 2018 Co-Chair, SickKids Summer Research (SSuRe) Program
    2015 – 2017 Member, Research Finance Transformation Advisory Committee
    2014 – 2016 Chair, Research Associate Advisory Committee
    2014 – 2016 Member, Research Training Centre Management Committee
    2015 – 2016 Member, SickKids Summer Research (SSuRe) Program
    2014 – 2016 Member, Career Development Committee

    Collapse Research 
    Collapse research activities and funding
         (Sean Egan)Jan 1, 2006 - Dec 31, 2006
    SickKids Hospital, Jacob’s Ladder Fund
    The Role of Intersectin1 in Down Syndrome-associated Learning Deficits
    Role: Co-Investigator

         (Michael Salter)Jan 1, 2015 - Dec 31, 2015
    Centre for Brain and Mental Health, SickKids Hospital
    Repairing human mitochondrial mutations in nervous system disorders using CRISPR/Cas9
    Role: Co-Investigator

         (Michael Salter)Apr 1, 2016 - Mar 30, 2019
    Krembil Foundation
    Defining New Horizons in Neuropathic Pain
    Role: Co-Writer

         (Thomas Eiwegger)Jul 1, 2017 - Jun 30, 2018
    HSBC Bank of Canada - Catalyst Grant
    Development of a human precision cut, organotypic gut slice model to study allergic and chronic inflammatory conditions in vitro
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Moriarty O, Tu Y, Sengar AS, Salter MW, Beggs S, Walker SM. Priming of adult incision response by early life injury: neonatal microglial inhibition has persistent but sexually dimorphic effects in adult rats. J Neurosci. 2019 Feb 22. PMID: 30796159.
      View in: PubMed
    2. Fraser J, Essebier A, Brown AS, Davila RA, Sengar AS, Tu Y, Ensbey KS, Day BW, Scott MP, Gronostajski RM, Wainwright BJ, Boden M, Harvey TJ, Piper M. Granule neuron precursor cell proliferation is regulated by NFIX and intersectin 1 during postnatal cerebellar development. Brain Struct Funct. 2019 Mar; 224(2):811-827. PMID: 30511336.
      View in: PubMed
    3. Jevtic S, Sengar AS, Salter MW, McLaurin J. The role of the immune system in Alzheimer disease: Etiology and treatment. Ageing Res Rev. 2017 Nov; 40:84-94. PMID: 28941639.
      View in: PubMed
    4. Fernandes DJ, Ellegood J, Askalan R, Blakely RD, Dicicco-Bloom E, Egan SE, Osborne LR, Powell CM, Raznahan A, Robins DM, Salter MW, Sengar AS, Veenstra-VanderWeele J, Henkelman RM, Lerch JP. Spatial gene expression analysis of neuroanatomical differences in mouse models. Neuroimage. 2017 12; 163:220-230. PMID: 28882630.
      View in: PubMed
    5. Hildebrand ME, Xu J, Dedek A, Li Y, Sengar AS, Beggs S, Lombroso PJ, Salter MW. Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing. Cell Rep. 2016 12 06; 17(10):2753-2765. PMID: 27926876.
      View in: PubMed
    6. Zhang WB, Ross PJ, Tu Y, Wang Y, Beggs S, Sengar AS, Ellis J, Salter MW. Fyn Kinase regulates GluN2B subunit-dominant NMDA receptors in human induced pluripotent stem cell-derived neurons. Sci Rep. 2016 Apr 04; 6:23837. PMID: 27040756; PMCID: PMC4819183.
    7. Sengar AS, Ellegood J, Yiu AP, Wang H, Wang W, Juneja SC, Lerch JP, Josselyn SA, Henkelman RM, Salter MW, Egan SE. Vertebrate intersectin1 is repurposed to facilitate cortical midline connectivity and higher order cognition. J Neurosci. 2013 Feb 27; 33(9):4055-65. PMID: 23447614.
      View in: PubMed
    8. Liu XJ, Gingrich JR, Vargas-Caballero M, Dong YN, Sengar A, Beggs S, Wang SH, Ding HK, Frankland PW, Salter MW. Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex. Nat Med. 2008 Dec; 14(12):1325-32. PMID: 19011637; PMCID: PMC3616027.
    9. Wang W, Bouhours M, Gracheva EO, Liao EH, Xu K, Sengar AS, Xin X, Roder J, Boone C, Richmond JE, Zhen M, Egan SE. ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Traffic. 2008 May; 9(5):742-54. PMID: 18298590; PMCID: PMC3791081.
    10. Sengar AS, Wang W, Bishay J, Cohen S, Egan SE. The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15. EMBO J. 1999 Mar 01; 18(5):1159-71. PMID: 10064583; PMCID: PMC1171207.
    11. McPherson PS, de Heuvel E, Phillie J, Wang W, Sengar A, Egan S. EH domain-dependent interactions between Eps15 and clathrin-coated vesicle protein p95. Biochem Biophys Res Commun. 1998 Mar 27; 244(3):701-5. PMID: 9535728.
      View in: PubMed
    12. Sengar AS, Markley NA, Marini NJ, Young D. Mkh1, a MEK kinase required for cell wall integrity and proper response to osmotic and temperature stress in Schizosaccharomyces pombe. Mol Cell Biol. 1997 Jul; 17(7):3508-19. PMID: 9199286; PMCID: PMC232204.
    13. Sengar DP, Hampton N, Goldstein R, Sengar AS. Comprehensive typing of HLA-DPB1 alleles by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Clin Invest Med. 1995 Dec; 18(6):465-72. PMID: 8714790.
      View in: PubMed
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