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Teniposide

"Teniposide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

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A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.


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This graph shows the total number of publications written about "Teniposide" by people in this website by year, and whether "Teniposide" was a major or minor topic of these publications.
Bar chart showing 4 publications over 3 distinct years, with a maximum of 2 publications in 1996
To see the data from this visualization as text, click here.
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