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Gail Otulakowski

TitleSenior Research Associate
InstitutionThe Hospital for Sick Children
DepartmentTranslational Medicine
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tamura T, Otulakowski G, Kavanagh BP. Could nanotechnology make vitamin E therapeutically effective? Am J Physiol Lung Cell Mol Physiol. 2019 Jan 01; 316(1):L1-L5. PMID: 30407864.
      View in: PubMed
    2. Katira BH, Engelberts D, Otulakowski G, Giesinger RE, Yoshida T, Post M, Kuebler WM, Connelly KA, Kavanagh BP. Abrupt Deflation after Sustained Inflation Causes Lung Injury. Am J Respir Crit Care Med. 2018 Nov 01; 198(9):1165-1176. PMID: 29902384.
      View in: PubMed
    3. Yoshida T, Engelberts D, Otulakowski G, Katira B, Post M, Ferguson ND, Brochard L, Amato MBP, Kavanagh BP. Continuous Negative Abdominal Pressure Reduces Ventilator-induced Lung Injury in a Porcine Model. Anesthesiology. 2018 07; 129(1):163-172. PMID: 29708892.
      View in: PubMed
    4. Otulakowski G, Engelberts D, Post M, Masterson C, Kavanagh BP. Mechanical Ventilation Induces Desensitization of Lung Axl Tyrosine Kinase Receptors. Anesthesiology. 2018 07; 129(1):143-153. PMID: 29474201.
      View in: PubMed
    5. Yoshida T, Engelberts D, Otulakowski G, Katira B, Ferguson ND, Brochard L, Amato MBP, Kavanagh BP. Continuous negative abdominal pressure: mechanism of action and comparison with prone position. J Appl Physiol (1985). 2018 Jul 01; 125(1):107-116. PMID: 29596015.
      View in: PubMed
    6. Yoshida T, Engelberts D, Otulakowski G, Katira B, Post M, Ferguson ND, Brochard L, Amato MBP, Kavanagh BP. Continuous Negative Abdominal Pressure Recruits Lungs at Lower Distending Pressures. Am J Respir Crit Care Med. 2018 Feb 15; 197(4):534-537. PMID: 28742375.
      View in: PubMed
    7. Otulakowski G, Engelberts D, Post M, Masterson C, Kavanagh BP. Hypercapnic Acidosis Regulates Mer Tyrosine Kinase Receptor Shedding and Activity. Am J Respir Cell Mol Biol. 2018 01; 58(1):132-134. PMID: 29286859.
      View in: PubMed
    8. Katira BH, Giesinger RE, Engelberts D, Zabini D, Kornecki A, Otulakowski G, Yoshida T, Kuebler WM, McNamara PJ, Connelly KA, Kavanagh BP. Adverse Heart-Lung Interactions in Ventilator-induced Lung Injury. Am J Respir Crit Care Med. 2017 12 01; 196(11):1411-1421. PMID: 28795839.
      View in: PubMed
    9. Otulakowski G, Engelberts D, Arima H, Hirate H, Bayir H, Post M, Kavanagh BP. a-Tocopherol transfer protein mediates protective hypercapnia in murine ventilator-induced lung injury. Thorax. 2017 06; 72(6):538-549. PMID: 28159772.
      View in: PubMed
    10. Kavanagh BP, Otulakowski G. Anesthetics and Lung Injury: Old Research, New Insights. Anesthesiology. 2015 Aug; 123(2):251-2. PMID: 26068208.
      View in: PubMed
    11. Yildiz C, Palaniyar N, Otulakowski G, Khan MA, Post M, Kuebler WM, Tanswell K, Belcastro R, Masood A, Engelberts D, Kavanagh BP. Mechanical ventilation induces neutrophil extracellular trap formation. Anesthesiology. 2015 Apr; 122(4):864-75. PMID: 25665049.
      View in: PubMed
    12. Masterson C, Otulakowski G, Kavanagh BP. Hypercapnia: clinical relevance and mechanisms of action. Curr Opin Crit Care. 2015 Feb; 21(1):7-12. PMID: 25546531.
      View in: PubMed
    13. Otulakowski G, Engelberts D, Gusarova GA, Bhattacharya J, Post M, Kavanagh BP. Hypercapnia attenuates ventilator-induced lung injury via a disintegrin and metalloprotease-17. J Physiol. 2014 Oct 15; 592(20):4507-21. PMID: 25085885.
      View in: PubMed
    14. Uematsu S, Engelberts D, Peltekova V, Otulakowski G, Post M, Kavanagh BP. Dissociation of inflammatory mediators and function: experimental lung injury in nonpulmonary sepsis. Crit Care Med. 2013 Jan; 41(1):151-8. PMID: 23128385.
      View in: PubMed
    15. Otulakowski G, Kavanagh BP. Hypercapnia in acute illness: sometimes good, sometimes not. Crit Care Med. 2011 Jun; 39(6):1581-2. PMID: 21610635.
      View in: PubMed
    16. Jaecklin T, Engelberts D, Otulakowski G, O'Brodovich H, Post M, Kavanagh BP. Lung-derived soluble mediators are pathogenic in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2011 Apr; 300(4):L648-58. PMID: 21239530.
      View in: PubMed
    17. Niitsu T, Tsuchida S, Peltekova V, Engelberts D, Copland I, Otulakowski G, Post M, Kavanagh BP. Cyclooxygenase inhibition in ventilator-induced lung injury. Anesth Analg. 2011 Jan; 112(1):143-9. PMID: 21048090.
      View in: PubMed
    18. Otulakowski G, Kavanagh BP. Hydrogen sulfide in lung injury: therapeutic hope from a toxic gas? Anesthesiology. 2010 Jul; 113(1):4-6. PMID: 20574223.
      View in: PubMed
    19. Jaecklin T, Otulakowski G, Kavanagh BP. Do soluble mediators cause ventilator-induced lung injury and multi-organ failure? Intensive Care Med. 2010 May; 36(5):750-7. PMID: 20232037.
      View in: PubMed
    20. Peltekova V, Engelberts D, Otulakowski G, Uematsu S, Post M, Kavanagh BP. Hypercapnic acidosis in ventilator-induced lung injury. Intensive Care Med. 2010 May; 36(5):869-78. PMID: 20213072.
      View in: PubMed
    21. Ngiam N, Peltekova V, Engelberts D, Otulakowski G, Post M, Kavanagh BP. Early growth response-1 worsens ventilator-induced lung injury by up-regulating prostanoid synthesis. Am J Respir Crit Care Med. 2010 May 01; 181(9):947-56. PMID: 20110555.
      View in: PubMed
    22. Rahman MS, Gandhi S, Otulakowski G, Duan W, Sarangapani A, O'Brodovich H. Long-term terbutaline exposure stimulates alpha1-Na+-K+-ATPase expression at posttranscriptional level in rat fetal distal lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2010 Jan; 298(1):L96-L104. PMID: 19880505.
      View in: PubMed
    23. Otulakowski G, Duan W, Sarangapani A, Gandhi S, O'Brodovich H. Glucocorticoid-mediated repression of REDD1 mRNA expression in rat fetal distal lung epithelial cells. Pediatr Res. 2009 May; 65(5):514-9. PMID: 19127203.
      View in: PubMed
    24. Gandhi SG, Law C, Duan W, Otulakowski G, O'Brodovich H. Pulmonary neuroendocrine cell-secreted factors may alter fetal lung liquid clearance. Pediatr Res. 2009 Mar; 65(3):274-8. PMID: 19092725.
      View in: PubMed
    25. Otulakowski G, Duan W, O'Brodovich H. Global and gene-specific translational regulation in rat lung development. Am J Respir Cell Mol Biol. 2009 May; 40(5):555-67. PMID: 18952566.
      View in: PubMed
    26. O'Brodovich H, Yang P, Gandhi S, Otulakowski G. Amiloride-insensitive Na+ and fluid absorption in the mammalian distal lung. Am J Physiol Lung Cell Mol Physiol. 2008 Mar; 294(3):L401-8. PMID: 18162600.
      View in: PubMed
    27. Hillar A, Otulakowski G, O Brodovich H. Purification and characterization of a recombinant rat prohaptoglobin expressed in baculovirus-infected Sf9 insect cells. Protein Expr Purif. 2007 Oct; 55(2):246-56. PMID: 17681809.
      View in: PubMed
    28. Gandhi SG, Rafii B, Harris MS, Garces A, Mahuran D, Chen XJ, Bao HF, Jain L, Eaton DC, Otulakowski G, O'Brodovich H. Effects of cardiogenic edema fluid on ion and fluid transport in the adult lung. Am J Physiol Lung Cell Mol Physiol. 2007 Sep; 293(3):L651-9. PMID: 17557800.
      View in: PubMed
    29. Otulakowski G, Duan W, Gandhi S, O'brodovich H. Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia. Am J Respir Cell Mol Biol. 2007 Oct; 37(4):457-66. PMID: 17556672.
      View in: PubMed
    30. Elias N, Rafii B, Rahman M, Otulakowski G, Cutz E, O'Brodovich H. The role of alpha-, beta-, and gamma-ENaC subunits in distal lung epithelial fluid absorption induced by pulmonary edema fluid. Am J Physiol Lung Cell Mol Physiol. 2007 Sep; 293(3):L537-45. PMID: 17513453.
      View in: PubMed
    31. Otulakowski G, O'Brodovich H. Thyroid hormone and Na+-K+-ATPase: more than simple transcription. Am J Physiol Lung Cell Mol Physiol. 2007 Jan; 292(1):L4-5. PMID: 16951130.
      View in: PubMed
    32. Otulakowski G, Rafii B, Harris M, O'Brodovich H. Oxygen and glucocorticoids modulate alphaENaC mRNA translation in fetal distal lung epithelium. Am J Respir Cell Mol Biol. 2006 Feb; 34(2):204-12. PMID: 16210692.
      View in: PubMed
    33. Banasikowska K, Post M, Cutz E, O'Brodovich H, Otulakowski G. Expression of epithelial sodium channel alpha-subunit mRNAs with alternative 5'-untranslated regions in the developing human lung. Am J Physiol Lung Cell Mol Physiol. 2004 Sep; 287(3):L608-15. PMID: 15169674.
      View in: PubMed
    34. Helve O, Pitkänen OM, Andersson S, O'Brodovich H, Kirjavainen T, Otulakowski G. Low expression of human epithelial sodium channel in airway epithelium of preterm infants with respiratory distress. Pediatrics. 2004 May; 113(5):1267-72. PMID: 15121940.
      View in: PubMed
    35. Otulakowski G, Rafii B, O'Brodovich H. Differential translational efficiency of ENaC subunits during lung development. Am J Respir Cell Mol Biol. 2004 Jun; 30(6):862-70. PMID: 14672917.
      View in: PubMed
    36. Rafii B, Gillie DJ, Sulowski C, Hannam V, Cheung T, Otulakowski G, Barker PM, O'Brodovich H. Pulmonary oedema fluid induces non-alpha-ENaC-dependent Na(+) transport and fluid absorption in the distal lung. J Physiol. 2002 10 15; 544(2):537-48. PMID: 12381825.
      View in: PubMed
    37. Bremner HR, Freywald T, O'Brodovich HM, Otulakowski G. Promoter analysis of the gene encoding the beta-subunit of the rat amiloride-sensitive epithelial sodium channel. Am J Physiol Lung Cell Mol Physiol. 2002 Jan; 282(1):L124-34. PMID: 11741824.
      View in: PubMed
    38. Otulakowski G, Freywald T, Wen Y, O'Brodovich H. Translational activation and repression by distinct elements within the 5'-UTR of ENaC alpha-subunit mRNA. Am J Physiol Lung Cell Mol Physiol. 2001 Nov; 281(5):L1219-31. PMID: 11597914.
      View in: PubMed
    39. Smith DE, Otulakowski G, Yeger H, Post M, Cutz E, O'Brodovich HM. Epithelial Na(+) channel (ENaC) expression in the developing normal and abnormal human perinatal lung. Am J Respir Crit Care Med. 2000 Apr; 161(4 Pt 1):1322-31. PMID: 10764330.
      View in: PubMed
    40. Rafii B, Coutinho C, Otulakowski G, O'Brodovich H. Oxygen induction of epithelial Na(+) transport requires heme proteins. Am J Physiol Lung Cell Mol Physiol. 2000 Feb; 278(2):L399-406. PMID: 10666125.
      View in: PubMed
    41. Otulakowski G, Rafii B, Bremner HR, O'Brodovich H. Structure and hormone responsiveness of the gene encoding the alpha-subunit of the rat amiloride-sensitive epithelial sodium channel. Am J Respir Cell Mol Biol. 1999 May; 20(5):1028-40. PMID: 10226074.
      View in: PubMed
    42. Rafii B, Tanswell AK, Otulakowski G, Pitkänen O, Belcastro-Taylor R, O'Brodovich H. O2-induced ENaC expression is associated with NF-kappaB activation and blocked by superoxide scavenger. Am J Physiol. 1998 10; 275(4):L764-70. PMID: 9755109.
      View in: PubMed
    43. Otulakowski G, Flueckiger-Staub S, Ellis L, Ramlall K, Staub O, Smith D, Durie P, O'Brodovich H. Relation between alpha, beta, and gamma human amiloride- sensitive epithelial Na+ channel mRNA levels and nasal epithelial potential difference in healthy men. Am J Respir Crit Care Med. 1998 Oct; 158(4):1213-20. PMID: 9769284.
      View in: PubMed
    44. Giguère V, Tini M, Flock G, Ong E, Evans RM, Otulakowski G. Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors. Genes Dev. 1994 Mar 01; 8(5):538-53. PMID: 7926749.
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    45. Tini M, Otulakowski G, Breitman ML, Tsui LC, Giguère V. An everted repeat mediates retinoic acid induction of the gamma F-crystallin gene: evidence of a direct role for retinoids in lens development. Genes Dev. 1993 Feb; 7(2):295-307. PMID: 8436299.
      View in: PubMed
    46. Scherer SW, Otulakowski G, Robinson BH, Tsui LC. Localization of the human dihydrolipoamide dehydrogenase gene (DLD) to 7q31----q32. Cytogenet Cell Genet. 1991; 56(3-4):176-7. PMID: 2055113.
      View in: PubMed
    47. Robinson BH, Chun K, Mackay N, Otulakowski G, Petrova-Benedict R, Willard H. Isolated and combined deficiencies of the alpha-keto acid dehydrogenase complexes. Ann N Y Acad Sci. 1989; 573:337-46. PMID: 2634350.
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    48. Otulakowski G, Robinson BH, Willard HF. Gene for lipoamide dehydrogenase maps to human chromosome 7. Somat Cell Mol Genet. 1988 Jul; 14(4):411-4. PMID: 3399966.
      View in: PubMed
    49. Otulakowski G, Robinson BH. Isolation and sequence determination of cDNA clones for porcine and human lipoamide dehydrogenase. Homology to other disulfide oxidoreductases. J Biol Chem. 1987 Dec 25; 262(36):17313-8. PMID: 3693355.
      View in: PubMed
    50. Otulakowski GL, Shewen PE, Udoh AE, Mellors A, Wilkie BN. Proteolysis of sialoglycoprotein by Pasteurella haemolytica cytotoxic culture supernatant. Infect Immun. 1983 Oct; 42(1):64-70. PMID: 6352504.
      View in: PubMed
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