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Anne-Marie LamHonWah

TitleSenior Research Associate - RI
InstitutionThe Hospital for Sick Children
DepartmentNeurology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lamhonwah AM, Tein I. Expression of the organic cation/carnitine transporter family (Octn1,-2 and-3) in mdx muscle and heart: Implications for early carnitine therapy in Duchenne muscular dystrophy to improve cellular carnitine homeostasis. Clin Chim Acta. 2020 Jun; 505:92-97. PMID: 32070725.
      View in: PubMed
    2. Verbeeten KC, Lamhonwah AM, Bulman D, Faghfoury H, Chakraborty P, Tein I, Geraghty MT. Carnitine uptake defect due to a 5'UTR mutation in a pedigree with false positives and false negatives on Newborn screening. Mol Genet Metab. 2020 03; 129(3):213-218. PMID: 31864849.
      View in: PubMed
    3. Lamhonwah AM, Baric I, Lamhonwah J, Grubic M, Tein I. Attention deficit/hyperactivity disorder as an associated feature in OCTN2 deficiency with novel deletion (p.T440-Y449). Clin Case Rep. 2018 04; 6(4):585-591. PMID: 29636919.
      View in: PubMed
    4. Nabavi Nouri M, Lamhonwah AM, Tein I. Novel myophosphorylase mutation (p.Arg94Pro) with progressive exercise intolerance. Clin Case Rep. 2018 03; 6(3):499-501. PMID: 29531726.
      View in: PubMed
    5. Tkachyova I, Fan X, LamHonWah AM, Fedyshyn B, Tein I, Mahuran DJ, Schulze A. NDST1 Preferred Promoter Confirmation and Identification of Corresponding Transcriptional Inhibitors as Substrate Reduction Agents for Multiple Mucopolysaccharidosis Disorders. PLoS One. 2016; 11(9):e0162145. PMID: 27657498.
      View in: PubMed
    6. Zolkipli Z, Mai L, Lamhonwah AM, Tein I. The mdx mouse as a model for carnitine deficiency in the pathogenesis of Duchenne muscular dystrophy. Muscle Nerve. 2012 Nov; 46(5):767-72. PMID: 23055315.
      View in: PubMed
    7. Zolkipli Z, Pedersen CB, Lamhonwah AM, Gregersen N, Tein I. Vulnerability to oxidative stress in vitro in pathophysiology of mitochondrial short-chain acyl-CoA dehydrogenase deficiency: response to antioxidants. PLoS One. 2011 Apr 01; 6(4):e17534. PMID: 21483766.
      View in: PubMed
    8. Lamhonwah AM, Mai L, Chung C, Lamhonwah D, Ackerley C, Tein I. Upregulation of mammary gland OCTNs maintains carnitine homeostasis in suckling infants. Biochem Biophys Res Commun. 2011 Jan 28; 404(4):1010-5. PMID: 21187065.
      View in: PubMed
    9. Lamhonwah AM, Bear CE, Huan LJ, Kim Chiaw P, Ackerley CA, Tein I. Cystic fibrosis transmembrane conductance regulator in human muscle: Dysfunction causes abnormal metabolic recovery in exercise. Ann Neurol. 2010 Jun; 67(6):802-8. PMID: 20517942.
      View in: PubMed
    10. Lamhonwah AM, Wong J, Tam C, Mai L, Tein I. Organic cation/carnitine transporter family expression patterns in adult murine heart. Pathol Res Pract. 2009; 205(6):395-402. PMID: 19233567.
      View in: PubMed
    11. Tein I, Elpeleg O, Ben-Zeev B, Korman SH, Lossos A, Lev D, Lerman-Sagie T, Leshinsky-Silver E, Vockley J, Berry GT, Lamhonwah AM, Matern D, Roe CR, Gregersen N. Short-chain acyl-CoA dehydrogenase gene mutation (c.319C>T) presents with clinical heterogeneity and is candidate founder mutation in individuals of Ashkenazi Jewish origin. Mol Genet Metab. 2008 Feb; 93(2):179-89. PMID: 18054510.
      View in: PubMed
    12. Lamhonwah AM, Hawkins CE, Tam C, Wong J, Mai L, Tein I. Expression patterns of the organic cation/carnitine transporter family in adult murine brain. Brain Dev. 2008 Jan; 30(1):31-42. PMID: 17576045.
      View in: PubMed
    13. Lamhonwah AM, Tein I. Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria. Biochem Biophys Res Commun. 2006 Jul 14; 345(4):1315-25. PMID: 16729965.
      View in: PubMed
    14. Lamhonwah AM, Ackerley CA, Tilups A, Edwards VD, Wanders RJ, Tein I. OCTN3 is a mammalian peroxisomal membrane carnitine transporter. Biochem Biophys Res Commun. 2005 Dec 30; 338(4):1966-72. PMID: 16288981.
      View in: PubMed
    15. Lamhonwah AM, Ackerley C, Onizuka R, Tilups A, Lamhonwah D, Chung C, Tao KS, Tellier R, Tein I. Epitope shared by functional variant of organic cation/carnitine transporter, OCTN1, Campylobacter jejuni and Mycobacterium paratuberculosis may underlie susceptibility to Crohn's disease at 5q31. Biochem Biophys Res Commun. 2005 Dec 02; 337(4):1165-75. PMID: 16246312.
      View in: PubMed
    16. Lamhonwah AM, Onizuka R, Olpin SE, Muntoni F, Tein I. OCTN2 mutation (R254X) found in Saudi Arabian kindred: recurrent mutation or ancient founder mutation? J Inherit Metab Dis. 2004; 27(4):473-6. PMID: 15303004.
      View in: PubMed
    17. Xuan W, Lamhonwah AM, Librach C, Jarvi K, Tein I. Characterization of organic cation/carnitine transporter family in human sperm. Biochem Biophys Res Commun. 2003 Jun 20; 306(1):121-8. PMID: 12788076.
      View in: PubMed
    18. Lamhonwah AM, Skaug J, Scherer SW, Tein I. A third human carnitine/organic cation transporter (OCTN3) as a candidate for the 5q31 Crohn's disease locus (IBD5). Biochem Biophys Res Commun. 2003 Jan 31; 301(1):98-101. PMID: 12535646.
      View in: PubMed
    19. Lamhonwah AM, Olpin SE, Pollitt RJ, Vianey-Saban C, Divry P, Guffon N, Besley GT, Onizuka R, De Meirleir LJ, Cvitanovic-Sojat L, Baric I, Dionisi-Vici C, Fumic K, Maradin M, Tein I. Novel OCTN2 mutations: no genotype-phenotype correlations: early carnitine therapy prevents cardiomyopathy. Am J Med Genet. 2002 Aug 15; 111(3):271-84. PMID: 12210323.
      View in: PubMed
    20. Lamhonwah AM, Tein I. GFP-Human high-affinity carnitine transporter OCTN2 protein: subcellular localization and functional restoration of carnitine uptake in mutant cell lines with the carnitine transporter defect. Biochem Biophys Res Commun. 1999 Nov 02; 264(3):909-14. PMID: 10544029.
      View in: PubMed
    21. Siminovitch KA, Lamhonwah AM, Somani AK, Cardiff R, Mills GB. Involvement of the SHP-1 tyrosine phosphatase in regulating B lymphocyte antigen receptor signaling, proliferation and transformation. Curr Top Microbiol Immunol. 1999; 246:291-7; discussion 298. PMID: 10396068.
      View in: PubMed
    22. Lamhonwah AM, Tein I. Carnitine uptake defect: frameshift mutations in the human plasmalemmal carnitine transporter gene. Biochem Biophys Res Commun. 1998 Nov 18; 252(2):396-401. PMID: 9826541.
      View in: PubMed
    23. Kolluri R, Shehabeldin A, Peacocke M, Lamhonwah AM, Teichert-Kuliszewska K, Weissman SM, Siminovitch KA. Identification of WASP mutations in patients with Wiskott-Aldrich syndrome and isolated thrombocytopenia reveals allelic heterogeneity at the WAS locus. Hum Mol Genet. 1995 Jul; 4(7):1119-26. PMID: 8528198.
      View in: PubMed
    24. Wakamatsu N, Benoit G, Lamhonwah AM, Zhang ZX, Trasler JM, Triggs-Raine BL, Gravel RA. Structural organization, sequence, and expression of the mouse HEXA gene encoding the alpha subunit of hexosaminidase A. Genomics. 1994 Nov 01; 24(1):110-9. PMID: 7896264.
      View in: PubMed
    25. Gravel RA, Akerman BR, Lamhonwah AM, Loyer M, Léon-del-Rio A, Italiano I. Mutations participating in interallelic complementation in propionic acidemia. Am J Hum Genet. 1994 Jul; 55(1):51-8. PMID: 8023851.
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    26. Lamhonwah AM, Leclerc D, Loyer M, Clarizio R, Gravel RA. Correction of the metabolic defect in propionic acidemia fibroblasts by microinjection of a full-length cDNA or RNA transcript encoding the propionyl-CoA carboxylase beta subunit. Genomics. 1994 Feb; 19(3):500-5. PMID: 8188292.
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    27. Xie B, McInnes B, Neote K, Lamhonwah AM, Mahuran D. Isolation and expression of a full-length cDNA encoding the human GM2 activator protein. Biochem Biophys Res Commun. 1991 Jun 28; 177(3):1217-23. PMID: 2059210.
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    28. Lamhonwah AM, Troxel CE, Schuster S, Gravel RA. Two distinct mutations at the same site in the PCCB gene in propionic acidemia. Genomics. 1990 Oct; 8(2):249-54. PMID: 2249848.
      View in: PubMed
    29. Lamhonwah AM, Mahuran D, Gravel RA. Human mitochondrial propionyl-CoA carboxylase: localization of the N-terminus of the pro- and mature alpha chains in the deduced primary sequence of a full-length cDNA. Nucleic Acids Res. 1989 Jun 12; 17(11):4396. PMID: 2740237.
      View in: PubMed
    30. Arpaia E, Dumbrille-Ross A, Maler T, Neote K, Tropak M, Troxel C, Stirling JL, Pitts JS, Bapat B, Lamhonwah AM, et al. Identification of an altered splice site in Ashkenazi Tay-Sachs disease. Nature. 1988 May 05; 333(6168):85-6. PMID: 3362213.
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    31. Lamhonwah AM, Gravel RA. Propionicacidemia: absence of alpha-chain mRNA in fibroblasts from patients of the pccA complementation group. Am J Hum Genet. 1987 Dec; 41(6):1124-31. PMID: 3687944.
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    32. Lamhonwah AM, Quan F, Gravel RA. Sequence homology around the biotin-binding site of human propionyl-CoA carboxylase and pyruvate carboxylase. Arch Biochem Biophys. 1987 May 01; 254(2):631-6. PMID: 3555348.
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    33. Lamhonwah AM, Barankiewicz TJ, Willard HF, Mahuran DJ, Quan F, Gravel RA. Isolation of cDNA clones coding for the alpha and beta chains of human propionyl-CoA carboxylase: chromosomal assignments and DNA polymorphisms associated with PCCA and PCCB genes. Proc Natl Acad Sci U S A. 1986 Jul; 83(13):4864-8. PMID: 3460076.
      View in: PubMed
    34. O'Dowd BF, Quan F, Willard HF, Lamhonwah AM, Korneluk RG, Lowden JA, Gravel RA, Mahuran DJ. Isolation of cDNA clones coding for the beta subunit of human beta-hexosaminidase. Proc Natl Acad Sci U S A. 1985 Feb; 82(4):1184-8. PMID: 2579389.
      View in: PubMed
    35. Guise KS, Korneluk RG, Waye J, Lamhonwah AM, Quan F, Palmer R, Ganschow RE, Sly WS, Gravel RA. Isolation and expression in Escherichia coli of a cDNA clone encoding human beta-glucuronidase. Gene. 1985; 34(1):105-10. PMID: 3924735.
      View in: PubMed
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