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Karen Aitken

TitleResearch Associate-RI
InstitutionThe Hospital for Sick Children
DepartmentDevelopmental & Stem Cell Biology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Schröder A, Aitken KJ, Jiang JX, Sidler M, Tölg C, Siebenaller A, Jeffrey N, Kirwan T, Leslie B, Wu C, Weksberg R, Delgado-Olguin P, Bägli DJ. Persistent myopathy despite release of partial obstruction: in vivo reversal of dysfunction and transcriptional responses using rapamycin. FASEB J. 2020 Mar; 34(3):3594-3615. PMID: 31984552.
      View in: PubMed
    2. Sidler M, Aitken KJ, Jiang JX, Sotiropoulos C, Aggarwal P, Anees A, Chong C, Siebenaller A, Thanabalasingam T, White JM, Choufani S, Weksberg R, Sangiorgi B, Wrana J, Delgado-Olguin P, Bägli DJ. DNA Methylation Reduces the Yes-Associated Protein 1/WW Domain Containing Transcription Regulator 1 Pathway and Prevents Pathologic Remodeling during Bladder Obstruction by Limiting Expression of BDNF. Am J Pathol. 2018 10; 188(10):2177-2194. PMID: 30121256.
      View in: PubMed
    3. Sidler M, Aitken KJ, Forward S, Vitkin A, Bagli DJ. Non-invasive voiding assessment in conscious mice. Bladder (San Franc). 2018; 5(2):e33. PMID: 32775475.
      View in: PubMed
    4. Sidler M, Aitken K, Bägli D. Reply by the Authors. Urology. 2017 12; 110:264-265. PMID: 28822842.
      View in: PubMed
    5. Sidler M, Aitken KJ, Jiang JX, Bägli DJ. Nerve-sparing Mid-urethral Obstruction (NeMO) in Female Small Rodents. J Vis Exp. 2017 04 25; (122). PMID: 28518071.
      View in: PubMed
    6. Sidler M, Aitken K, Jiang J, Bijos D, Belik J, Bägli DJ. Finding NeMO-Nerve-sparing Mid-urethral Obstruction: A Pathophysiologically Accurate Model of Rodent Partial Bladder Outlet Obstruction. Urology. 2017 Jul; 105:208.e1-208.e9. PMID: 28366702.
      View in: PubMed
    7. Bayat Mokhtari R, Baluch N, Ka Hon Tsui M, Kumar S, S Homayouni T, Aitken K, Das B, Baruchel S, Yeger H. Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma. BMC Cancer. 2017 02 24; 17(1):156. PMID: 28235409.
      View in: PubMed
    8. Ting K, Aitken KJ, Penna F, Samiei AN, Sidler M, Jiang JX, Ibrahim F, Tolg C, Delgado-Olguin P, Rosenblum N, Bägli DJ. Uropathogenic E. coli (UPEC) Infection Induces Proliferation through Enhancer of Zeste Homologue 2 (EZH2). PLoS One. 2016; 11(3):e0149118. PMID: 26964089.
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    9. Wu C, Sui G, Archer SN, Sassone-Corsi P, Aitken K, Bagli D, Chen Y. Local receptors as novel regulators for peripheral clock expression. FASEB J. 2014 Nov; 28(11):4610-6. PMID: 25145629.
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    10. Alali S, Aitken KJ, Schröder A, Gribble A, Bagli DJ, Vitkin IA. Assessment of local structural disorders of the bladder wall in partial bladder outlet obstruction using polarized light imaging. Biomed Opt Express. 2014 Feb 01; 5(2):621-9. PMID: 24575354.
      View in: PubMed
    11. Jesus LE, Schanaider A, Kirwan T, Aitken KJ, Caldas ML, Fonseca E, Marchenko A, Bagli DJ, Pippi-Salle JL. Reduced flow after tubularized incised plate urethroplasty--increased fibrogenesis, elastin fiber loss or neither? J Urol. 2014 Jun; 191(6):1856-62. PMID: 24316090.
      View in: PubMed
    12. Jiang JX, Aitken KJ, Sotiropoulos C, Sotiropolous C, Kirwan T, Panchal T, Zhang N, Pu S, Wodak S, Tolg C, Bägli DJ. Phenotypic switching induced by damaged matrix is associated with DNA methyltransferase 3A (DNMT3A) activity and nuclear localization in smooth muscle cells (SMC). PLoS One. 2013; 8(8):e69089. PMID: 24282625.
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    13. Tolg C, Ahsan A, Dworski S, Kirwan T, Yu J, Aitken K, Bägli DJ. Pathologic bladder microenvironment attenuates smooth muscle differentiation of skin derived precursor cells: implications for tissue regeneration. PLoS One. 2013; 8(4):e59413. PMID: 23560047.
      View in: PubMed
    14. Schröder A, Kirwan TP, Jiang JX, Aitken KJ, Bägli DJ. Rapamycin attenuates bladder hypertrophy during long-term outlet obstruction in vivo: tissue, matrix and mechanistic insights. J Urol. 2013 Jun; 189(6):2377-84. PMID: 23313213.
      View in: PubMed
    15. Wilkins S, Zhang KW, Mahfuz I, Quantin R, D'Cruz N, Hutson J, Ee M, Bagli D, Aitken K, Fong FN, Ng PK, Tsui SK, Fung WY, Banu T, Thakre A, Johar K, Jaureguizar E, Li L, Cheng W. Insertion/deletion polymorphisms in the ?Np63 promoter are a risk factor for bladder exstrophy epispadias complex. PLoS Genet. 2012; 8(12):e1003070. PMID: 23284286.
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    16. Jesus LE, Schanaider A, Patterson G, Marchenko A, Aitken KJ, Leslie B, Bagli DJ, Pippi-Salle JL. Urethral compliance in hypospadias operated by tubularized incised urethral plate (TIP) with and without a dorsal inlay graft: an experimental controlled study. World J Urol. 2013 Aug; 31(4):971-5. PMID: 23224038.
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    17. Alali S, Aitken KJ, Schröder A, Shröder A, Bagli DJ, Alex Vitkin I. Optical assessment of tissue anisotropy in ex vivo distended rat bladders. J Biomed Opt. 2012 Aug; 17(8):086010. PMID: 23224197.
      View in: PubMed
    18. Tolg C, Sabha N, Cortese R, Panchal T, Ahsan A, Soliman A, Aitken KJ, Petronis A, Bägli DJ. Uropathogenic E. coli infection provokes epigenetic downregulation of CDKN2A (p16INK4A) in uroepithelial cells. Lab Invest. 2011 Jun; 91(6):825-36. PMID: 21242958.
      View in: PubMed
    19. Aitken KJ, Tolg C, Panchal T, Leslie B, Yu J, Elkelini M, Sabha N, Tse DJ, Lorenzo AJ, Hassouna M, Bägli DJ. Mammalian target of rapamycin (mTOR) induces proliferation and de-differentiation responses to three coordinate pathophysiologic stimuli (mechanical strain, hypoxia, and extracellular matrix remodeling) in rat bladder smooth muscle. Am J Pathol. 2010 Jan; 176(1):304-19. PMID: 20019183.
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    20. Aitken KJ, Bägli DJ. The bladder extracellular matrix. Part I: architecture, development and disease. Nat Rev Urol. 2009 Nov; 6(11):596-611. PMID: 19890339.
      View in: PubMed
    21. Aitken KJ, Bägli DJ. The bladder extracellular matrix. Part II: regenerative applications. Nat Rev Urol. 2009 Nov; 6(11):612-21. PMID: 19890340.
      View in: PubMed
    22. Elkelini MS, Aitken K, Bagli DJ, Hassouna MM. Effects of doxycycline on voiding behaviour of rats with bladder outlet obstruction. BJU Int. 2009 Feb; 103(4):537-40. PMID: 18990141.
      View in: PubMed
    23. Aitken KJ, Block G, Lorenzo A, Herz D, Sabha N, Dessouki O, Fung F, Szybowska M, Craig L, Bägli DJ. Mechanotransduction of extracellular signal-regulated kinases 1 and 2 mitogen-activated protein kinase activity in smooth muscle is dependent on the extracellular matrix and regulated by matrix metalloproteinases. Am J Pathol. 2006 Aug; 169(2):459-70. PMID: 16877348.
      View in: PubMed
    24. Halachmi S, Aitken KJ, Szybowska M, Sabha N, Dessouki S, Lorenzo A, Tse D, Bagli DJ. Role of signal transducer and activator of transcription 3 (STAT3) in stretch injury to bladder smooth muscle cells. Cell Tissue Res. 2006 Oct; 326(1):149-58. PMID: 16705451.
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    25. Sabha N, Aitken K, Lorenzo AJ, Szybowska M, Jairath A, Bägli DJ. Matrix metalloproteinase-7 and epidermal growth factor receptor mediate hypoxia-induced extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase activation and subsequent proliferation in bladder smooth muscle cells. In Vitro Cell Dev Biol Anim. 2006 May-Jun; 42(5-6):124-33. PMID: 16848631.
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    26. Hafez AT, Afshar K, Bägli DJ, Bahoric A, Aitken K, Smith CR, Khoury AE. Aerosol transfer of bladder urothelial and smooth muscle cells onto demucosalized colonic segments for porcine bladder augmentation in vivo: a 6-week experimental study. J Urol. 2005 Oct; 174(4 Pt 2):1663-7; discussion 1667-8. PMID: 16148677.
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    27. Herz DB, Aitken K, Bagli DJ. Collagen directly stimulates bladder smooth muscle cell growth in vitro: regulation by extracellular regulated mitogen activated protein kinase. J Urol. 2003 Nov; 170(5):2072-6. PMID: 14532856.
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    28. Hafez AT, Bagli DJ, Bahoric A, Aitken K, Smith CR, Herz D, Khoury AE. Aerosol transfer of bladder urothelial and smooth muscle cells onto demucosalized colonic segments: a pilot study. J Urol. 2003 Jun; 169(6):2316-9; discussion 2320. PMID: 12771789.
      View in: PubMed
    29. Upadhyay J, Aitken KJ, Damdar C, Bolduc S, Bagli DJ. Integrins expressed with bladder extracellular matrix after stretch injury in vivo mediate bladder smooth muscle cell growth in vitro. J Urol. 2003 Feb; 169(2):750-5. PMID: 12544357.
      View in: PubMed
    30. Capolicchio G, Aitken KJ, Gu JX, Reddy P, Bägli DJ. Extracellular matrix gene responses in a novel ex vivo model of bladder stretch injury. J Urol. 2001 Jun; 165(6 Pt 2):2235-40. PMID: 11371952.
      View in: PubMed
    31. Aitken K, Bägl DJ. Stretch-induced bladder smooth muscle cell (SMC) proliferation is mediated by RHAMM-dependent extracellular-regulated kinase (erk) signaling. Urology. 2001 Jun; 57(6 Suppl 1):109. PMID: 11378075.
      View in: PubMed
    32. Irie-Sasaki J, Sasaki T, Matsumoto W, Opavsky A, Cheng M, Welstead G, Griffiths E, Krawczyk C, Richardson CD, Aitken K, Iscove N, Koretzky G, Johnson P, Liu P, Rothstein DM, Penninger JM. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature. 2001 Jan 18; 409(6818):349-54. PMID: 11201744.
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    33. Liu P, Aitken K, Kong YY, Opavsky MA, Martino T, Dawood F, Wen WH, Kozieradzki I, Bachmaier K, Straus D, Mak TW, Penninger JM. The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease. Nat Med. 2000 Apr; 6(4):429-34. PMID: 10742150.
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    34. Opavsky MA, Penninger J, Aitken K, Wen WH, Dawood F, Mak T, Liu P. Susceptibility to myocarditis is dependent on the response of alphabeta T lymphocytes to coxsackieviral infection. Circ Res. 1999 Sep 17; 85(6):551-8. PMID: 10488058.
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    35. Martino TA, Petric M, Brown M, Aitken K, Gauntt CJ, Richardson CD, Chow LH, Liu PP. Cardiovirulent coxsackieviruses and the decay-accelerating factor (CD55) receptor. Virology. 1998 May 10; 244(2):302-14. PMID: 9601501.
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    36. Atra A, Ward HC, Aitken K, Boyle M, Dicks-Mireaux C, Duffy PG, Mitchell CD, Plowman PN, Ransley PG, Pritchard J. Conservative surgery in multimodal therapy for pelvic rhabdomyosarcoma in children. Br J Cancer. 1994 Nov; 70(5):1004-8. PMID: 7947076.
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    37. Sury MR, Brown JL, Aitken K. Anaesthesia for conjoined twins during magnetic resonance imaging. Eur J Anaesthesiol. 1994 Mar; 11(2):139-42. PMID: 8174536.
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    38. O'Hare AE, Aitken K, Eden OB. Computerized psychometry screening in long-term survivors of childhood acute lymphoblastic leukemia. Pediatr Hematol Oncol. 1988; 5(3):197-208. PMID: 3152965.
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