 Protein Tyrosine Phosphatase, Non-Receptor Type 2
"Protein Tyrosine Phosphatase, Non-Receptor Type 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of non-receptor protein tyrosine phosphatase that is closely-related to PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1. Alternative splicing of the mRNA for this phosphatase results in the production at two gene products, one of which includes a C-terminal nuclear localization domain that may be involved in the transport of the protein to the CELL NUCLEUS. Although initially referred to as T-cell protein tyrosine phosphatase the expression of this subtype occurs widely.
| Descriptor ID |
D054578
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| MeSH Number(s) |
D08.811.277.352.650.775.300.200 D12.644.360.585.200 D12.776.476.564.200
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein Tyrosine Phosphatase, Non-Receptor Type 2".
Below are MeSH descriptors whose meaning is more specific than "Protein Tyrosine Phosphatase, Non-Receptor Type 2".
This graph shows the total number of publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 2" by people in this website by year, and whether "Protein Tyrosine Phosphatase, Non-Receptor Type 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 | | 2006 | 0 | 2 | 2 | | 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 2" by people in Profiles.
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St-Germain JR, Taylor P, Zhang W, Li Z, Ketela T, Moffat J, Neel BG, Trudel S, Moran MF. Differential regulation of FGFR3 by PTPN1 and PTPN2. Proteomics. 2015 Jan; 15(2-3):419-33.
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Simoncic PD, McGlade CJ, Tremblay ML. PTP1B and TC-PTP: novel roles in immune-cell signaling. Can J Physiol Pharmacol. 2006 Jul; 84(7):667-75.
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Simoncic PD, Bourdeau A, Lee-Loy A, Rohrschneider LR, Tremblay ML, Stanley ER, McGlade CJ. T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation. Mol Cell Biol. 2006 Jun; 26(11):4149-60.
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Simoncic PD, Lee-Loy A, Barber DL, Tremblay ML, McGlade CJ. The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. Curr Biol. 2002 Mar 19; 12(6):446-53.
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