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Last name

Leanne Wybenga-Groot

TitleService Mgr Res Core Fac (PM)
InstitutionThe Hospital for Sick Children
DepartmentCell Biology
Address555 University Avenue
Toronto ON M5G 1X8
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    Collapse Biography 
    Collapse education and training
    University of Toronto, Toronto, CanadaPhD12/2004Molecular and Medical Genetics
    McMaster University, Hamilton, CanadaMSc06/1999Biochemistry
    McMaster University, Hamilton, CanadaBSc06/1997Biochemistry
    Collapse awards and honors
    2012Exceptional Trainee Award, Cell Biology, The Hospital for Sick Children
    2011 - 2013American Brain Tumor Association Postdoctoral Fellowship, The Hospital for Sick Children
    2008 - 2011Canadian Institutes of Health Research Fellowship Award, The Hospital for Sick Children
    2001 - 2004Canadian Institutes of Health Research Doctoral Research Award, Samuel Lunenfeld Research Institute
    2003Dr. Joe A Connolly Memorial Award for Cell Biology, University of Toronto
    2002L.W. Macpherson Microbiology Award, University of Toronto
    1999 - 2001NSERC Postgraduate Scholarship B, Samuel Lunenfeld Research Institute
    1997 - 1999NSERC Postgraduate Scholarship A, McMaster University

    Collapse Overview 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tong J, Krieger JR, Taylor P, Bagshaw R, Kang J, Jeedigunta S, Wybenga-Groot LE, Zhang W, Badr H, Mirhadi S, Pham NA, Coyaud É, Yu M, Li M, Cabanero M, Raught B, Maynes JT, Hawkins C, Tsao MS, Moran MF. Cancer proteome and metabolite changes linked to SHMT2. PLoS One. 2020; 15(9):e0237981. PMID: 32903271.
      View in: PubMed
    2. Saraon P, Snider J, Kalaidzidis Y, Wybenga-Groot LE, Weiss K, Rai A, Radulovich N, Drecun L, Vuckovic N, Vucetic A, Wong V, Thériault B, Pham NA, Park JH, Datti A, Wang J, Pathmanathan S, Aboualizadeh F, Lyakisheva A, Yao Z, Wang Y, Joseph B, Aman A, Moran MF, Prakesch M, Poda G, Marcellus R, Uehling D, Samaržija M, Jakopovic M, Tsao MS, Shepherd FA, Sacher A, Leighl N, Akhmanova A, Al-Awar R, Zerial M, Stagljar I. A drug discovery platform to identify compounds that inhibit EGFR triple mutants. Nat Chem Biol. 2020 05; 16(5):577-586. PMID: 32094923.
      View in: PubMed
    3. Scott BM, Wybenga-Groot LE, McGlade CJ, Heon E, Peisajovich SG, Chang BSW. Screening of Chemical Libraries Using a Yeast Model of Retinal Disease. SLAS Discov. 2019 12; 24(10):969-977. PMID: 31556794.
      View in: PubMed
    4. Krieger JR, Wybenga-Groot LE, Tong J, Bache N, Tsao MS, Moran MF. Evosep One Enables Robust Deep Proteome Coverage Using Tandem Mass Tags while Significantly Reducing Instrument Time. J Proteome Res. 2019 05 03; 18(5):2346-2353. PMID: 30938160.
      View in: PubMed
    5. Jin LL, Wybenga-Groot LE, Tong J, Taylor P, Minden MD, Trudel S, McGlade CJ, Moran MF. Tyrosine phosphorylation of the Lyn Src homology 2 (SH2) domain modulates its binding affinity and specificity. Mol Cell Proteomics. 2015 Mar; 14(3):695-706. PMID: 25587033.
      View in: PubMed
    6. Wybenga-Groot LE, McGlade CJ. RTK SLAP down: the emerging role of Src-like adaptor protein as a key player in receptor tyrosine kinase signaling. Cell Signal. 2015 Feb; 27(2):267-74. PMID: 25446260.
      View in: PubMed
    7. Wybenga-Groot LE, Ho CS, Sweeney FD, Ceccarelli DF, McGlade CJ, Durocher D, Sicheri F. Structural basis of Rad53 kinase activation by dimerization and activation segment exchange. Cell Signal. 2014 Sep; 26(9):1825-36. PMID: 24815189.
      View in: PubMed
    8. Wybenga-Groot LE, McGlade CJ. Crystal structure of Src-like adaptor protein 2 reveals close association of SH3 and SH2 domains through ß-sheet formation. Cell Signal. 2013 Dec; 25(12):2702-8. PMID: 24018043.
      View in: PubMed
    9. Wolting CD, Griffiths EK, Sarao R, Prevost BC, Wybenga-Groot LE, McGlade CJ. Biochemical and computational analysis of LNX1 interacting proteins. PLoS One. 2011; 6(11):e26248. PMID: 22087225.
      View in: PubMed
    10. Littler DR, Walker JR, Davis T, Wybenga-Groot LE, Finerty PJ, Newman E, Mackenzie F, Dhe-Paganon S. A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Feb 01; 66(Pt 2):143-51. PMID: 20124709.
      View in: PubMed
    11. Warner N, Wybenga-Groot LE, Pawson T. Analysis of EphA4 receptor tyrosine kinase substrate specificity using peptide-based arrays. FEBS J. 2008 May; 275(10):2561-73. PMID: 18422655.
      View in: PubMed
    12. Wiesner S, Wybenga-Groot LE, Warner N, Lin H, Pawson T, Forman-Kay JD, Sicheri F. A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases. EMBO J. 2006 Oct 04; 25(19):4686-96. PMID: 16977320.
      View in: PubMed
    13. Burk DL, Ghuman N, Wybenga-Groot LE, Berghuis AM. X-ray structure of the AAC(6')-Ii antibiotic resistance enzyme at 1.8 A resolution; examination of oligomeric arrangements in GNAT superfamily members. Protein Sci. 2003 Mar; 12(3):426-37. PMID: 12592013.
      View in: PubMed
    14. Wybenga-Groot LE, Baskin B, Ong SH, Tong J, Pawson T, Sicheri F. Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region. Cell. 2001 Sep 21; 106(6):745-57. PMID: 11572780.
      View in: PubMed
    15. Wybenga-Groot LE, Draker K, Wright GD, Berghuis AM. Crystal structure of an aminoglycoside 6'-N-acetyltransferase: defining the GCN5-related N-acetyltransferase superfamily fold. Structure. 1999 May; 7(5):497-507. PMID: 10378269.
      View in: PubMed
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