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Philipp Maass

TitleScientist
InstitutionThe Hospital for Sick Children
DepartmentResearch Operations
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
ORCID ORCID Icon0000-0002-2742-8301 Additional info
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    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MA | USA2018lncRNAs | genome organization | live-cell imaging
    Experimental and Clinical Research Center & Max-Delbrueck-Center for Molecular Medicine, Berlin | Germany2015lncRNAs | Molecular Genetics
    Max-Delbrueck-Center for Molecular Medicine, Berlin | GermanyPhD10/2009Molecular Genetics
    Eberhard Karls University Tuebingen, Tuebingen | GermanyDiploma2005Virology | Immunology | Human Genetics
    Collapse awards and honors
    2018Walter-Siegenthaler Award, Walter-Siegenthaler Society
    2015 - 2018Postdoc fellowship , German Research Foundation (DFG)
    2013National Fellowship Award, European Society of Human Genetics (ESHG)
    2013Best selected talk, German Society of Human Genetics (GfH)
    2010Max Delbrück Center PostDoc fellowship, Max-Delbrück-Center for Molecular Medicine
    2006 - 2009Max Delbrück Center PhD scholarship , Max-Delbrück-Center for Molecular Medicine

    Collapse Overview 
    Collapse overview
    The proper organization of the genome is crucial for the regulation of genes. Interactions between genes and their regulators on the same chromosome are well characterized. Inter-chromosomal contacts between different chromosomes also exist, but their molecular mechanisms remain elusive and obscure. Determining how inter-chromosomal contacts are formed, and how they impact normal and disease states, is critical to better understand the biology and etiology of disease. Dr. Philipp Maass addresses this challenge by using state-of-the-art systems biology. The Maass lab focuses on regions of the non-coding genome that impact development and disease mechanisms in a bedside-to-bench approach.


    Collapse Research 
    Collapse research activities and funding
    MA-5028/1-2     (PG Maass)
    German Research Foundation (DFG)
    Molecular characterization of cis- and trans-acting gene and ncRNA regulation during human chondrogenesis

    MA-5028/1-3     (PG Maass)
    German Research Foundation (DFG)
    Molecular characterization of cis- and trans-acting gene and ncRNA regulation during human chondrogenesis

    MA-5028/2-1     (PG Maass)
    German Research Foundation (DFG)
    Functional characterization of mesenchymal stem cell-derived lncRNAs

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lips D, Ryabov A, Maass P. Brownian Asymmetric Simple Exclusion Process. Phys Rev Lett. 2018 Oct 19; 121(16):160601. PMID: 30387631.
      View in: PubMed
    2. Wolff MF, Lind PG, Maass P. Power grid stability under perturbation of single nodes: Effects of heterogeneity and internal nodes. Chaos. 2018 Oct; 28(10):103120. PMID: 30384670.
      View in: PubMed
    3. Maass PG, Barutcu AR, Rinn JL. Interchromosomal interactions: A genomic love story of kissing chromosomes. J Cell Biol. 2018 Sep 04. PMID: 30181316.
      View in: PubMed
    4. Maass PG, Weise A, Rittscher K, Lichtenwald J, Barutcu AR, Liehr T, Aydin A, Wefeld-Neuenfeld Y, Pölsler L, Tinschert S, Rinn JL, Luft FC, Bähring S. Reorganization of inter-chromosomal interactions in the 2q37-deletion syndrome. EMBO J. 2018 Aug 01; 37(15). PMID: 29921581.
      View in: PubMed
    5. Barutcu AR, Maass PG, Lewandowski JP, Weiner CL, Rinn JL. A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus. Nat Commun. 2018 04 13; 9(1):1444. PMID: 29654311.
      View in: PubMed
    6. Maass PG, Barutcu AR, Weiner CL, Rinn JL. Inter-chromosomal Contact Properties in Live-Cell Imaging and in Hi-C. Mol Cell. 2018 Mar 15; 69(6):1039-1045.e3. PMID: 29526697.
      View in: PubMed
    7. Shukla CJ, McCorkindale AL, Gerhardinger C, Korthauer KD, Cabili MN, Shechner DM, Irizarry RA, Maass PG, Rinn JL. High-throughput identification of RNA nuclear enrichment sequences. EMBO J. 2018 03 15; 37(6). PMID: 29335281.
      View in: PubMed
    8. Maass PG, Barutcu AR, Shechner DM, Weiner CL, Melé M, Rinn JL. Spatiotemporal allele organization by allele-specific CRISPR live-cell imaging (SNP-CLING). Nat Struct Mol Biol. 2018 Feb; 25(2):176-184. PMID: 29343869.
      View in: PubMed
    9. Maass PG, Glažar P, Memczak S, Dittmar G, Hollfinger I, Schreyer L, Sauer AV, Toka O, Aiuti A, Luft FC, Rajewsky N. A map of human circular RNAs in clinically relevant tissues. J Mol Med (Berl). 2017 Nov; 95(11):1179-1189. PMID: 28842720.
      View in: PubMed
    10. Eulenberg-Gustavus C, Bähring S, Maass PG, Luft FC, Kettritz R. Gene silencing and a novel monoallelic expression pattern in distinct CD177 neutrophil subsets. J Exp Med. 2017 Jul 03; 214(7):2089-2101. PMID: 28559244.
      View in: PubMed
    11. Toka O, Tank J, Schächterle C, Aydin A, Maass PG, Elitok S, Bartels-Klein E, Hollfinger I, Lindschau C, Mai K, Boschmann M, Rahn G, Movsesian MA, Müller T, Doescher A, Gnoth S, Mühl A, Toka HR, Wefeld-Neuenfeld Y, Utz W, Töpper A, Jordan J, Schulz-Menger J, Klussmann E, Bähring S, Luft FC. Clinical effects of phosphodiesterase 3A mutations in inherited hypertension with brachydactyly. Hypertension. 2015 Oct; 66(4):800-8. PMID: 26283042.
      View in: PubMed
    12. Maass PG, Aydin A, Luft FC, Schächterle C, Weise A, Stricker S, Lindschau C, Vaegler M, Qadri F, Toka HR, Schulz H, Krawitz PM, Parkhomchuk D, Hecht J, Hollfinger I, Wefeld-Neuenfeld Y, Bartels-Klein E, Mühl A, Kann M, Schuster H, Chitayat D, Bialer MG, Wienker TF, Ott J, Rittscher K, Liehr T, Jordan J, Plessis G, Tank J, Mai K, Naraghi R, Hodge R, Hopp M, Hattenbach LO, Busjahn A, Rauch A, Vandeput F, Gong M, Rüschendorf F, Hübner N, Haller H, Mundlos S, Bilginturan N, Movsesian MA, Klussmann E, Toka O, Bähring S. PDE3A mutations cause autosomal dominant hypertension with brachydactyly. Nat Genet. 2015 Jun; 47(6):647-53. PMID: 25961942.
      View in: PubMed
    13. Maass PG, Luft FC, Bähring S. Long non-coding RNA in health and disease. J Mol Med (Berl). 2014 Apr; 92(4):337-46. PMID: 24531795.
      View in: PubMed
    14. Maass PG, Rump A, Schulz H, Stricker S, Schulze L, Platzer K, Aydin A, Tinschert S, Goldring MB, Luft FC, Bähring S. A misplaced lncRNA causes brachydactyly in humans. J Clin Invest. 2012 Nov; 122(11):3990-4002. PMID: 23093776; PMCID: PMC3485082.
    15. Toka O, Maass PG, Aydin A, Toka H, Hübner N, Rüschendorf F, Gong M, Luft FC, Bähring S. Childhood hypertension in autosomal-dominant hypertension with brachydactyly. Hypertension. 2010 Nov; 56(5):988-94. PMID: 20837885.
      View in: PubMed
    16. Maass PG, Wirth J, Aydin A, Rump A, Stricker S, Tinschert S, Otero M, Tsuchimochi K, Goldring MB, Luft FC, Bähring S. A cis-regulatory site downregulates PTHLH in translocation t(8;12)(q13;p11.2) and leads to Brachydactyly Type E. Hum Mol Genet. 2010 Mar 01; 19(5):848-60. PMID: 20015959; PMCID: PMC3031338.
    17. Naumann U, Maass P, Gleske AK, Aulwurm S, Weller M, Eisele G. Glioma gene therapy with soluble transforming growth factor-beta receptors II and III. Int J Oncol. 2008 Oct; 33(4):759-65. PMID: 18813789.
      View in: PubMed
    18. Bähring S, Kann M, Neuenfeld Y, Gong M, Chitayat D, Toka HR, Toka O, Plessis G, Maass P, Rauch A, Aydin A, Luft FC. Inversion region for hypertension and brachydactyly on chromosome 12p features multiple splicing and noncoding RNA. Hypertension. 2008 Feb; 51(2):426-31. PMID: 18086950.
      View in: PubMed
    19. Barta P, Monti J, Maass PG, Gorzelniak K, Müller DN, Dechend R, Luft FC, Hübner N, Sharma AM. A gene expression analysis in rat kidney following high and low salt intake. J Hypertens. 2002 Jun; 20(6):1115-20. PMID: 12023680.
      View in: PubMed
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