DNA Restriction Enzymes
"DNA Restriction Enzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.
Descriptor ID |
D004262
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MeSH Number(s) |
D08.811.150.280 D08.811.277.352.335.350.300 D08.811.277.352.355.325.300
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Concept/Terms |
DNA Restriction Enzymes- DNA Restriction Enzymes
- Enzymes, DNA Restriction
- Restriction Enzymes, DNA
- Restriction Endonucleases
- Endonucleases, Restriction
- Restriction Endonuclease
- Endonuclease, Restriction
- DNA Restriction Enzyme
- Restriction Enzyme, DNA
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Below are MeSH descriptors whose meaning is more general than "DNA Restriction Enzymes".
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This graph shows the total number of publications written about "DNA Restriction Enzymes" by people in this website by year, and whether "DNA Restriction Enzymes" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1980 | 1 | 0 | 1 | 1983 | 0 | 2 | 2 | 1984 | 0 | 5 | 5 | 1985 | 0 | 1 | 1 | 1986 | 0 | 3 | 3 | 1988 | 0 | 1 | 1 | 1990 | 1 | 1 | 2 | 1991 | 0 | 1 | 1 | 1996 | 0 | 1 | 1 | 1999 | 0 | 1 | 1 | 2004 | 0 | 1 | 1 | 2005 | 0 | 1 | 1 | 2011 | 1 | 0 | 1 | 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Restriction Enzymes" by people in Profiles.
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Unterberger A, Dubuc AM, Taylor MD. Genome-wide methylation analysis. Methods Mol Biol. 2012; 863:303-17.
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López Castel A, Nakamori M, Thornton CA, Pearson CE. Identification of restriction endonucleases sensitive to 5-cytosine methylation at non-CpG sites, including expanded (CAG)n/(CTG)n repeats. Epigenetics. 2011 Apr; 6(4):416-20.
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Ailenberg M, Goldenberg NM, Silverman M. Description of a PCR-based technique for DNA splicing and mutagenesis by producing 5' overhangs with run through stop DNA synthesis utilizing Ara-C. BMC Biotechnol. 2005 Sep 01; 5:23.
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Yao S, Sukonnik T, Kean T, Bharadwaj RR, Pasceri P, Ellis J. Retrovirus silencing, variegation, extinction, and memory are controlled by a dynamic interplay of multiple epigenetic modifications. Mol Ther. 2004 Jul; 10(1):27-36.
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Vincent JB, Kovacs M, Krol R, Barr CL, Kennedy JL. Intergenerational CAG repeat expansion at ERDA1 in a family with childhood-onset depression, schizoaffective disorder, and recurrent major depression. Am J Med Genet. 1999 Feb 05; 88(1):79-82.
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Bourke B, Sherman PM, Woodward D, Lior H, Chan VL. Pulsed-field gel electrophoresis indicates genotypic heterogeneity among Campylobacter upsaliensis strains. FEMS Microbiol Lett. 1996 Sep 15; 143(1):57-61.
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Pearson CE, Frappier L, Zannis-Hadjopoulos M. Plasmids bearing mammalian DNA-replication origin-enriched (ors) fragments initiate semiconservative replication in a cell-free system. Biochim Biophys Acta. 1991 Oct 08; 1090(2):156-66.
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Melmer G, Sood R, Rommens J, Rego D, Tsui LC, Buchwald M. Isolation of clones on chromosome 7 that contain recognition sites for rare-cutting enzymes by oligonucleotide hybridization. Genomics. 1990 Jun; 7(2):173-81.
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Adeli K, Ogbonna G. Rapid purification of human DNA from whole blood for potential application in clinical chemistry laboratories. Clin Chem. 1990 Feb; 36(2):261-4.
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Taylor SA, Lillicrap DP, Blanchette V, Giles AR, Holden JJ, White BN. A complete deletion of the factor IX gene and new TaqI variant in a hemophilia B kindred. Hum Genet. 1988 Jul; 79(3):273-6.
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