 Protein Tyrosine Phosphatase, Non-Receptor Type 12
"Protein Tyrosine Phosphatase, Non-Receptor Type 12" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of a N-terminal catalytic domain and a large C-terminal domain that is enriched in PROLINE, GLUTAMIC ACID, SERINE, and THREONINE residues (PEST sequences). The phosphatase subtype is ubiquitously expressed and implicated in the regulation of a variety of biological processes such as CELL MOVEMENT; CYTOKINESIS; focal adhesion disassembly; and LYMPHOCYTE ACTIVATION.
| Descriptor ID |
D054594
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| MeSH Number(s) |
D08.811.277.352.650.775.300.850 D12.644.360.585.850 D12.776.476.564.850
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| Concept/Terms |
Protein Tyrosine Phosphatase, Non-Receptor Type 12- Protein Tyrosine Phosphatase, Non-Receptor Type 12
- Protein Tyrosine Phosphatase, Non Receptor Type 12
- PTP-PEST
- PEST-Enriched Phosphatase
- PEST Enriched Phosphatase
- Phosphatase, PEST-Enriched
- PEP Protein Tyrosine Phosphatase
- PEP PTPase
- PTPase, PEP
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Below are MeSH descriptors whose meaning is more general than "Protein Tyrosine Phosphatase, Non-Receptor Type 12".
Below are MeSH descriptors whose meaning is more specific than "Protein Tyrosine Phosphatase, Non-Receptor Type 12".
This graph shows the total number of publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 12" by people in this website by year, and whether "Protein Tyrosine Phosphatase, Non-Receptor Type 12" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 12" by people in Profiles.
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Xu Y, Taylor P, Andrade J, Ueberheide B, Shuch B, Glazer PM, Bindra RS, Moran MF, Linehan WM, Neel BG. Pathologic Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma. Cancer Res. 2018 12 01; 78(23):6539-6548.
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Charest A, Wagner J, Jacob S, McGlade CJ, Tremblay ML. Phosphotyrosine-independent binding of SHC to the NPLH sequence of murine protein-tyrosine phosphatase-PEST. Evidence for extended phosphotyrosine binding/phosphotyrosine interaction domain recognition specificity. J Biol Chem. 1996 Apr 05; 271(14):8424-9.
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