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Nancy Butcher

TitleSenior Research Associate - RI
InstitutionThe Hospital for Sick Children
DepartmentChild Health Evaluative Sciences
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
ORCID ORCID Icon0000-0002-5152-0108 Additional info
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    Collapse Biography 
    Collapse education and training
    Dalhousie University, Halifax, Nova ScotiaBSc2008Neuroscience
    Dalhousie University, Halifax, Nova ScotiaMSc2010Psychology & Neuroscience
    University of Toronto, Toronto, OntarioPhD2015Medical Science

    Collapse Overview 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Butcher NJ, Mew EJ, Monsour A, Szatmari P, Monga S, Offringa M. Response to "Trials for depressive disorder in adolescents: the emperor's new clothes," a letter to the editor by Alain Braillon, MD, PhD. J Clin Epidemiol. 2020 Aug 27. PMID: 32860976.
      View in: PubMed
    2. Monga S, Monsour A, Stallwood E, Desai R, Cleverley K, Courtney D, Henderson J, Korczak D, Krause K, Smith M, Szatmari P, Offringa M, Butcher N. Core Outcome Set Development for Adolescent Major Depressive Disorder Clinical Trials: A Registered Report. J Am Acad Child Adolesc Psychiatry. 2020 Nov; 59(11):1297-1298. PMID: 33126995.
      View in: PubMed
    3. Butcher NJ, Mew EJ, Monsour A, Chan AW, Moher D, Offringa M. Outcome reporting recommendations for clinical trial protocols and reports: a scoping review. Trials. 2020 Jul 08; 21(1):620. PMID: 32641085.
      View in: PubMed
    4. Mew EJ, Monsour A, Saeed L, Santos L, Patel S, Courtney DB, Watson PN, Szatmari P, Offringa M, Monga S, Butcher NJ. Systematic scoping review identifies heterogeneity in outcomes measured in adolescent depression clinical trials. J Clin Epidemiol. 2020 Oct; 126:71-79. PMID: 32561367.
      View in: PubMed
    5. Monsour A, Mew EJ, Patel S, Chee-A-Tow A, Saeed L, Santos L, Courtney DB, Watson PN, Monga S, Szatmari P, Offringa M, Butcher NJ. Primary outcome reporting in adolescent depression clinical trials needs standardization. BMC Med Res Methodol. 2020 05 25; 20(1):129. PMID: 32450810.
      View in: PubMed
    6. Monga S, Offringa M, Butcher NJ, Szatmari P. From Research to Practice: The Importance of Appropriate Outcome Selection, Measurement, and Reporting in Pediatric Mental Health Research. J Am Acad Child Adolesc Psychiatry. 2020 04; 59(4):497-500. PMID: 32220402.
      View in: PubMed
    7. Chan W, Thurairajah P, Butcher N, Oosterwijk C, Wever K, Eichler I, Thompson C, Junker A, Offringa M, Preston J. Guidance on development and operation of Young Persons' Advisory Groups. Arch Dis Child. 2020 09; 105(9):875-880. PMID: 32209556.
      View in: PubMed
    8. Ching CRK, Gutman BA, Sun D, Villalon Reina J, Ragothaman A, Isaev D, Zavaliangos-Petropulu A, Lin A, Jonas RK, Kushan L, Pacheco-Hansen L, Vajdi A, Forsyth JK, Jalbrzikowski M, Bakker G, van Amelsvoort T, Antshel KM, Fremont W, Kates WR, Campbell LE, McCabe KL, Craig MC, Daly E, Gudbrandsen M, Murphy CM, Murphy DG, Murphy KC, Fiksinski A, Koops S, Vorstman J, Crowley TB, Emanuel BS, Gur RE, McDonald-McGinn DM, Roalf DR, Ruparel K, Schmitt JE, Zackai EH, Durdle CA, Goodrich-Hunsaker NJ, Simon TJ, Bassett AS, Butcher NJ, Chow EWC, Vila-Rodriguez F, Cunningham A, Doherty J, Linden DE, Moss H, Owen MJ, van den Bree M, Crossley NA, Repetto GM, Thompson PM, Bearden CE. Mapping Subcortical Brain Alterations in 22q11.2 Deletion Syndrome: Effects of Deletion Size and Convergence With Idiopathic Neuropsychiatric Illness. Am J Psychiatry. 2020 07 01; 177(7):589-600. PMID: 32046535.
      View in: PubMed
    9. Cleynen I, Engchuan W, Hestand MS, Heung T, Holleman AM, Johnston HR, Monfeuga T, McDonald-McGinn DM, Gur RE, Morrow BE, Swillen A, Vorstman JAS, Bearden CE, Chow EWC, van den Bree M, Emanuel BS, Vermeesch JR, Warren ST, Owen MJ, Chopra P, Cutler DJ, Duncan R, Kotlar AV, Mulle JG, Voss AJ, Zwick ME, Diacou A, Golden A, Guo T, Lin JR, Wang T, Zhang Z, Zhao Y, Marshall C, Merico D, Jin A, Lilley B, Salmons HI, Tran O, Holmans P, Pardinas A, Walters JTR, Demaerel W, Boot E, Butcher NJ, Costain GA, Lowther C, Evers R, van Amelsvoort TAMJ, van Duin E, Vingerhoets C, Breckpot J, Devriendt K, Vergaelen E, Vogels A, Crowley TB, McGinn DE, Moss EM, Sharkus RJ, Unolt M, Zackai EH, Calkins ME, Gallagher RS, Gur RC, Tang SX, Fritsch R, Ornstein C, Repetto GM, Breetvelt E, Duijff SN, Fiksinski A, Moss H, Niarchou M, Murphy KC, Prasad SE, Daly EM, Gudbrandsen M, Murphy CM, Murphy DG, Buzzanca A, Fabio FD, Digilio MC, Pontillo M, Marino B, Vicari S, Coleman K, Cubells JF, Ousley OY, Carmel M, Gothelf D, Mekori-Domachevsky E, Michaelovsky E, Weinberger R, Weizman A, Kushan L, Jalbrzikowski M, Armando M, Eliez S, Sandini C, Schneider M, Béna FS, Antshel KM, Fremont W, Kates WR, Belzeaux R, Busa T, Philip N, Campbell LE, McCabe KL, Hooper SR, Schoch K, Shashi V, Simon TJ, Tassone F, Arango C, Fraguas D, García-Miñaúr S, Morey-Canyelles J, Rosell J, Suñer DH, Raventos-Simic J, Epstein MP, Williams NM, Bassett AS. Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion. Mol Psychiatry. 2020 Feb 03. PMID: 32015465.
      View in: PubMed
    10. Pugliese M, Tingley K, Chow A, Pallone N, Smith M, Rahman A, Chakraborty P, Geraghty MT, Irwin J, Tessier L, Nicholls SG, Offringa M, Butcher NJ, Iverson R, Clifford TJ, Stockler S, Hutton B, Paik K, Tao J, Skidmore B, Coyle D, Duddy K, Dyack S, Greenberg CR, Ghai SJ, Karp N, Korngut L, Kronick J, MacKenzie A, MacKenzie J, Maranda B, Mitchell JJ, Potter M, Prasad C, Schulze A, Sparkes R, Taljaard M, Trakadis Y, Walia J, Potter BK. Outcomes in pediatric studies of medium-chain acyl-coA dehydrogenase (MCAD) deficiency and phenylketonuria (PKU): a review. Orphanet J Rare Dis. 2020 01 14; 15(1):12. PMID: 31937333.
      View in: PubMed
    11. Ding S, Mew EJ, Chee-A-Tow A, Offringa M, Butcher NJ, Moore GP. Neurodevelopmental outcome descriptions in cohorts of extremely preterm children. Arch Dis Child Fetal Neonatal Ed. 2020 Sep; 105(5):510-519. PMID: 31932362.
      View in: PubMed
    12. Butcher NJ, Tricco AC, Offringa M, Moher D, Galica J. Training researchers in publication science: why, what, and how. J Clin Epidemiol. 2020 01; 117:165-167. PMID: 31465843.
      View in: PubMed
    13. Zinkstok JR, Boot E, Bassett AS, Hiroi N, Butcher NJ, Vingerhoets C, Vorstman JAS, van Amelsvoort TAMJ. Neurobiological perspective of 22q11.2 deletion syndrome. Lancet Psychiatry. 2019 11; 6(11):951-960. PMID: 31395526.
      View in: PubMed
    14. Joachim KC, Farid-Kapadia M, Butcher NJ, Chee-A-Tow A, Monsour A, Cohen E, Mahant S, Guttmann A, Offringa M. Core outcome set for children with neurological impairment and tube feeding. Dev Med Child Neurol. 2020 02; 62(2):201-206. PMID: 31372989.
      View in: PubMed
    15. Szatmari P, Offringa M, Butcher NJ, Monga S. Counting What Counts: The Case for Harmonized Outcomes in Child and Youth Mental Health Research. J Am Acad Child Adolesc Psychiatry. 2019 07; 58(7):656-658. PMID: 31229181.
      View in: PubMed
    16. Knaapen M, Hall NJ, van der Lee JH, Butcher NJ, Offringa M, Van Heurn EWE, Bakx R, Gorter RR. Establishing a core outcome set for treatment of uncomplicated appendicitis in children: study protocol for an international Delphi survey. BMJ Open. 2019 05 22; 9(5):e028861. PMID: 31123006.
      View in: PubMed
    17. Butcher NJ, Monsour A, Mew EJ, Szatmari P, Pierro A, Kelly LE, Farid-Kapadia M, Chee-A-Tow A, Saeed L, Monga S, Ungar W, Terwee CB, Vohra S, Fergusson D, Askie LM, Williamson PR, Chan AW, Moher D, Offringa M. Improving outcome reporting in clinical trial reports and protocols: study protocol for the Instrument for reporting Planned Endpoints in Clinical Trials (InsPECT). Trials. 2019 Mar 06; 20(1):161. PMID: 30841935.
      View in: PubMed
    18. Butcher NJ, Mew EJ, Saeed L, Monsour A, Chee-A-Tow A, Chan AW, Moher D, Offringa M. Guidance for reporting outcomes in clinical trials: scoping review protocol. BMJ Open. 2019 02 19; 9(2):e023001. PMID: 30782872.
      View in: PubMed
    19. Monsour A, Mew EJ, Szatmari P, Patel S, Saeed L, Offringa M, Butcher NJ. Outcomes reported in randomised clinical trials of major depressive disorder treatments in adolescents: a systematic scoping review protocol. BMJ Open. 2019 01 15; 9(1):e024191. PMID: 30782729.
      View in: PubMed
    20. Kelly LE, Dyson MP, Butcher NJ, Balshaw R, London AJ, Neilson CJ, Junker A, Mahmud SM, Driedger SM, Wang X. Considerations for adaptive design in pediatric clinical trials: study protocol for a systematic review, mixed-methods study, and integrated knowledge translation plan. Trials. 2018 Oct 19; 19(1):572. PMID: 30340624.
      View in: PubMed
    21. Galica J, Chee-A-Tow A, Gupta S, Jaiswal A, Monsour A, Tricco AC, Cobey KD, Butcher NJ. Learning best-practices in journalology: course description and attendee insights into the inaugural EQUATOR Canada Publication School. BMC Proc. 2018; 12(Suppl 10):18. PMID: 30540288.
      View in: PubMed
    22. Sumitomo A, Horike K, Hirai K, Butcher N, Boot E, Sakurai T, Nucifora FC, Bassett AS, Sawa A, Tomoda T. A mouse model of 22q11.2 deletions: Molecular and behavioral signatures of Parkinson's disease and schizophrenia. Sci Adv. 2018 08; 4(8):eaar6637. PMID: 30116778.
      View in: PubMed
    23. Fiksinski AM, Breetvelt EJ, Lee YJ, Boot E, Butcher N, Palmer L, Chow EWC, Kahn RS, Vorstman JAS, Bassett AS. Neurocognition and adaptive functioning in a genetic high risk model of schizophrenia. Psychol Med. 2019 04; 49(6):1047-1054. PMID: 30064532.
      View in: PubMed
    24. Sun D, Ching CRK, Lin A, Forsyth JK, Kushan L, Vajdi A, Jalbrzikowski M, Hansen L, Villalon-Reina JE, Qu X, Jonas RK, van Amelsvoort T, Bakker G, Kates WR, Antshel KM, Fremont W, Campbell LE, McCabe KL, Daly E, Gudbrandsen M, Murphy CM, Murphy D, Craig M, Vorstman J, Fiksinski A, Koops S, Ruparel K, Roalf DR, Gur RE, Schmitt JE, Simon TJ, Goodrich-Hunsaker NJ, Durdle CA, Bassett AS, Chow EWC, Butcher NJ, Vila-Rodriguez F, Doherty J, Cunningham A, van den Bree MBM, Linden DEJ, Moss H, Owen MJ, Murphy KC, McDonald-McGinn DM, Emanuel B, van Erp TGM, Turner JA, Thompson PM, Bearden CE. Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size. Mol Psychiatry. 2020 08; 25(8):1822-1834. PMID: 29895892.
      View in: PubMed
    25. Butcher NJ, Boot E, Lang AE, Andrade D, Vorstman J, McDonald-McGinn D, Bassett AS. Neuropsychiatric expression and catatonia in 22q11.2 deletion syndrome: An overview and case series. . 2018 10; 176(10):2146-2159. PMID: 29777584.
      View in: PubMed
    26. Boot E, Butcher NJ, Udow S, Marras C, Mok KY, Kaneko S, Barrett MJ, Prontera P, Berman BD, Masellis M, Dufournet B, Nguyen K, Charles P, Mutez E, Danaila T, Jacquette A, Colin O, Drapier S, Borg M, Fiksinski AM, Vergaelen E, Swillen A, Vogels A, Plate A, Perandones C, Gasser T, Clerinx K, Bourdain F, Mills K, Williams NM, Wood NW, Booij J, Lang AE, Bassett AS. Typical features of Parkinson disease and diagnostic challenges with microdeletion 22q11.2. Neurology. 2018 06 05; 90(23):e2059-e2067. PMID: 29752303.
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    27. Palmer LD, Butcher NJ, Boot E, Hodgkinson KA, Heung T, Chow EWC, Guna A, Crowley TB, Zackai E, McDonald-McGinn DM, Bassett AS. Elucidating the diagnostic odyssey of 22q11.2 deletion syndrome. . 2018 04; 176(4):936-944. PMID: 29575622.
      View in: PubMed
    28. Butcher NJ, Marras C, Pondal M, Rusjan P, Boot E, Christopher L, Repetto GM, Fritsch R, Chow EWC, Masellis M, Strafella AP, Lang AE, Bassett AS. Neuroimaging and clinical features in adults with a 22q11.2 deletion at risk of Parkinson's disease. Brain. 2017 May 01; 140(5):1371-1383. PMID: 28369257.
      View in: PubMed
    29. Wither RG, Borlot F, MacDonald A, Butcher NJ, Chow EWC, Bassett AS, Andrade DM. 22q11.2 deletion syndrome lowers seizure threshold in adult patients without epilepsy. Epilepsia. 2017 06; 58(6):1095-1101. PMID: 28448680.
      View in: PubMed
    30. Butcher NJ, Merico D, Zarrei M, Ogura L, Marshall CR, Chow EWC, Lang AE, Scherer SW, Bassett AS. Whole-genome sequencing suggests mechanisms for 22q11.2 deletion-associated Parkinson's disease. PLoS One. 2017; 12(4):e0173944. PMID: 28430790.
      View in: PubMed
    31. Butcher NJ, Horne MK, Mellick GD, Fowler CJ, Masters CL, Minchin RF. Sulfotransferase 1A3/4 copy number variation is associated with neurodegenerative disease. Pharmacogenomics J. 2018 04; 18(2):209-214. PMID: 28374858.
      View in: PubMed
    32. Voll SL, Boot E, Butcher NJ, Cooper S, Heung T, Chow EW, Silversides CK, Bassett AS. Obesity in adults with 22q11.2 deletion syndrome. Genet Med. 2017 02; 19(2):204-208. PMID: 27537705.
      View in: PubMed
    33. Merico D, Zarrei M, Costain G, Ogura L, Alipanahi B, Gazzellone MJ, Butcher NJ, Thiruvahindrapuram B, Nalpathamkalam T, Chow EW, Andrade DM, Frey BJ, Marshall CR, Scherer SW, Bassett AS. Whole-Genome Sequencing Suggests Schizophrenia Risk Mechanisms in Humans with 22q11.2 Deletion Syndrome. G3 (Bethesda). 2015 Sep 16; 5(11):2453-61. PMID: 26384369.
      View in: PubMed
    34. Guna A, Butcher NJ, Bassett AS. Comparative mapping of the 22q11.2 deletion region and the potential of simple model organisms. J Neurodev Disord. 2015; 7(1):18. PMID: 26137170.
      View in: PubMed
    35. Boot E, Butcher NJ, Vorstman JA, van Amelsvoort TA, Fung WL, Bassett AS. Pharmacological treatment of 22q11.2 deletion syndrome-related psychoses. Pharmacopsychiatry. 2015 Sep; 48(6):219-20. PMID: 26091278.
      View in: PubMed
    36. Van L, Butcher NJ, Costain G, Ogura L, Chow EW, Bassett AS. Fetal growth and gestational factors as predictors of schizophrenia in 22q11.2 deletion syndrome. Genet Med. 2016 Apr; 18(4):350-5. PMID: 26087175.
      View in: PubMed
    37. Vorstman JA, Breetvelt EJ, Duijff SN, Eliez S, Schneider M, Jalbrzikowski M, Armando M, Vicari S, Shashi V, Hooper SR, Chow EW, Fung WL, Butcher NJ, Young DA, McDonald-McGinn DM, Vogels A, van Amelsvoort T, Gothelf D, Weinberger R, Weizman A, Klaassen PW, Koops S, Kates WR, Antshel KM, Simon TJ, Ousley OY, Swillen A, Gur RE, Bearden CE, Kahn RS, Bassett AS. Cognitive decline preceding the onset of psychosis in patients with 22q11.2 deletion syndrome. JAMA Psychiatry. 2015 Apr; 72(4):377-85. PMID: 25715178.
      View in: PubMed
    38. Butcher NJ, Fung WL, Fitzpatrick L, Guna A, Andrade DM, Lang AE, Chow EW, Bassett AS. Response to clozapine in a clinically identifiable subtype of schizophrenia. Br J Psychiatry. 2015 Jun; 206(6):484-91. PMID: 25745132.
      View in: PubMed
    39. Boot E, Butcher NJ, van Amelsvoort TA, Lang AE, Marras C, Pondal M, Andrade DM, Fung WL, Bassett AS. Movement disorders and other motor abnormalities in adults with 22q11.2 deletion syndrome. . 2015 Mar; 167A(3):639-45. PMID: 25684639.
      View in: PubMed
    40. Fung WL, Butcher NJ, Costain G, Andrade DM, Boot E, Chow EW, Chung B, Cytrynbaum C, Faghfoury H, Fishman L, García-Miñaúr S, George S, Lang AE, Repetto G, Shugar A, Silversides C, Swillen A, van Amelsvoort T, McDonald-McGinn DM, Bassett AS. Practical guidelines for managing adults with 22q11.2 deletion syndrome. Genet Med. 2015 Aug; 17(8):599-609. PMID: 25569435.
      View in: PubMed
    41. Merico D, Costain G, Butcher NJ, Warnica W, Ogura L, Alfred SE, Brzustowicz LM, Bassett AS. MicroRNA Dysregulation, Gene Networks, and Risk for Schizophrenia in 22q11.2 Deletion Syndrome. Front Neurol. 2014; 5:238. PMID: 25484875.
      View in: PubMed
    42. Butcher NJ, Kiehl TR, Hazrati LN, Chow EW, Rogaeva E, Lang AE, Bassett AS. Association between early-onset Parkinson disease and 22q11.2 deletion syndrome: identification of a novel genetic form of Parkinson disease and its clinical implications. JAMA Neurol. 2013 Nov; 70(11):1359-66. PMID: 24018986.
      View in: PubMed
    43. Butcher NJ, Friedrich AB, Lu Z, Tanimoto H, Meinertzhagen IA. Different classes of input and output neurons reveal new features in microglomeruli of the adult Drosophila mushroom body calyx. J Comp Neurol. 2012 Jul 01; 520(10):2185-201. PMID: 22237598.
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    44. Butcher NJ, Chow EW, Costain G, Karas D, Ho A, Bassett AS. Functional outcomes of adults with 22q11.2 deletion syndrome. Genet Med. 2012 Oct; 14(10):836-43. PMID: 22744446.
      View in: PubMed
    45. Knowles-Barley S, Butcher NJ, Meinertzhagen IA, Armstrong JD. Biologically inspired EM image alignment and neural reconstruction. Bioinformatics. 2011 Aug 15; 27(16):2216-23. PMID: 21742636.
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    46. Leiss F, Groh C, Butcher NJ, Meinertzhagen IA, Tavosanis G. Synaptic organization in the adult Drosophila mushroom body calyx. J Comp Neurol. 2009 Dec 20; 517(6):808-24. PMID: 19844895.
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    47. Butcher NJ, Boukouvala S, Sim E, Minchin RF. Pharmacogenetics of the arylamine N-acetyltransferases. Pharmacogenomics J. 2002; 2(1):30-42. PMID: 11990379.
      View in: PubMed
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