 Protein Structure, Tertiary
"Protein Structure, Tertiary" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
| Descriptor ID |
D017434
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| MeSH Number(s) |
G02.111.570.820.709.610
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| Concept/Terms |
Protein Structure, Tertiary- Protein Structure, Tertiary
- Peptide Domain
- Domain, Peptide
- Domains, Peptide
- Peptide Domains
- Protein Domains
- Domain, Protein
- Domains, Protein
- Protein Domain
- Tertiary Protein Structure
- Protein Structures, Tertiary
- Tertiary Protein Structures
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Below are MeSH descriptors whose meaning is more general than "Protein Structure, Tertiary".
Below are MeSH descriptors whose meaning is more specific than "Protein Structure, Tertiary".
This graph shows the total number of publications written about "Protein Structure, Tertiary" by people in this website by year, and whether "Protein Structure, Tertiary" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 1 | 2 | | 1995 | 0 | 1 | 1 | | 1996 | 0 | 1 | 1 | | 1997 | 1 | 0 | 1 | | 1998 | 0 | 3 | 3 | | 1999 | 0 | 4 | 4 | | 2000 | 1 | 12 | 13 | | 2001 | 0 | 21 | 21 | | 2002 | 0 | 22 | 22 | | 2003 | 0 | 18 | 18 | | 2004 | 1 | 17 | 18 | | 2005 | 0 | 15 | 15 | | 2006 | 0 | 18 | 18 | | 2007 | 0 | 15 | 15 | | 2008 | 0 | 12 | 12 | | 2009 | 0 | 19 | 19 | | 2010 | 0 | 11 | 11 | | 2011 | 0 | 12 | 12 | | 2012 | 0 | 13 | 13 | | 2013 | 0 | 17 | 17 | | 2014 | 0 | 17 | 17 | | 2015 | 0 | 8 | 8 | | 2016 | 0 | 6 | 6 | | 2017 | 0 | 1 | 1 | | 2018 | 1 | 2 | 3 |
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Below are the most recent publications written about "Protein Structure, Tertiary" by people in Profiles.
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Wiseman B, Nitharwal RG, Fedotovskaya O, Schäfer J, Guo H, Kuang Q, Benlekbir S, Sjöstrand D, Ädelroth P, Rubinstein JL, Brzezinski P, Högbom M. Structure of a functional obligate complex III2IV2 respiratory supercomplex from Mycobacterium smegmatis. Nat Struct Mol Biol. 2018 12; 25(12):1128-1136.
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Molinski SV, Shahani VM, Subramanian AS, MacKinnon SS, Woollard G, Laforet M, Laselva O, Morayniss LD, Bear CE, Windemuth A. Comprehensive mapping of cystic fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site. Proteins. 2018 08; 86(8):833-843.
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Laselva O, Molinski S, Casavola V, Bear CE. Correctors of the Major Cystic Fibrosis Mutant Interact through Membrane-Spanning Domains. Mol Pharmacol. 2018 06; 93(6):612-618.
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Hudson RP, Dawson JE, Chong PA, Yang Z, Millen L, Thomas PJ, Brouillette CG, Forman-Kay JD. Direct Binding of the Corrector VX-809 to Human CFTR NBD1: Evidence of an Allosteric Coupling between the Binding Site and the NBD1:CL4 Interface. Mol Pharmacol. 2017 08; 92(2):124-135.
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Wilson MD, Benlekbir S, Fradet-Turcotte A, Sherker A, Julien JP, McEwan A, Noordermeer SM, Sicheri F, Rubinstein JL, Durocher D. The structural basis of modified nucleosome recognition by 53BP1. Nature. 2016 08 04; 536(7614):100-3.
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Mazhab-Jafari MT, Rubinstein JL. Cryo-EM studies of the structure and dynamics of vacuolar-type ATPases. Sci Adv. 2016 07; 2(7):e1600725.
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Cromar GL, Zhao A, Xiong X, Swapna LS, Loughran N, Song H, Parkinson J. PhyloPro2.0: a database for the dynamic exploration of phylogenetically conserved proteins and their domain architectures across the Eukarya. Database (Oxford). 2016; 2016.
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Csizmok V, Follis AV, Kriwacki RW, Forman-Kay JD. Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling. Chem Rev. 2016 06 08; 116(11):6424-62.
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Freeman SA, Goyette J, Furuya W, Woods EC, Bertozzi CR, Bergmeier W, Hinz B, van der Merwe PA, Das R, Grinstein S. Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis. Cell. 2016 Jan 14; 164(1-2):128-140.
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Hall JD, Wang H, Byrnes LJ, Shanker S, Wang K, Efremov IV, Chong PA, Forman-Kay JD, Aulabaugh AE. Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy. Protein Sci. 2016 Feb; 25(2):360-73.
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