 Up-Regulation
"Up-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015854
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| MeSH Number(s) |
G02.111.087.880 G02.149.115.880 G05.355.315.850 G07.690.773.998
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| Concept/Terms |
Up-Regulation- Up-Regulation
- Up Regulation
- Upregulation
- Up-Regulation (Physiology)
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Below are MeSH descriptors whose meaning is more general than "Up-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Up-Regulation".
This graph shows the total number of publications written about "Up-Regulation" by people in this website by year, and whether "Up-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 0 | 1 | 1 | | 1995 | 0 | 1 | 1 | | 1996 | 1 | 1 | 2 | | 1997 | 0 | 2 | 2 | | 1998 | 0 | 4 | 4 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 1 | 3 | 4 | | 2002 | 1 | 5 | 6 | | 2003 | 0 | 4 | 4 | | 2004 | 0 | 6 | 6 | | 2005 | 1 | 3 | 4 | | 2006 | 0 | 6 | 6 | | 2007 | 0 | 3 | 3 | | 2008 | 1 | 2 | 3 | | 2009 | 1 | 6 | 7 | | 2010 | 0 | 9 | 9 | | 2011 | 2 | 11 | 13 | | 2012 | 1 | 12 | 13 | | 2013 | 2 | 5 | 7 | | 2014 | 0 | 5 | 5 | | 2015 | 0 | 8 | 8 | | 2016 | 1 | 2 | 3 | | 2017 | 0 | 9 | 9 | | 2018 | 0 | 12 | 12 | | 2019 | 1 | 3 | 4 |
To return to the timeline, click here.
Below are the most recent publications written about "Up-Regulation" by people in Profiles.
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Lee C, Lau E, Chusilp S, Filler R, Li B, Zhu H, Yamoto M, Pierro A. Protective effects of vitamin D against injury in intestinal epithelium. Pediatr Surg Int. 2019 Dec; 35(12):1395-1401.
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Musa J, Cidre-Aranaz F, Aynaud MM, Orth MF, Knott MML, Mirabeau O, Mazor G, Varon M, Hölting TLB, Grossetête S, Gartlgruber M, Surdez D, Gerke JS, Ohmura S, Marchetto A, Dallmayer M, Baldauf MC, Stein S, Sannino G, Li J, Romero-Pérez L, Westermann F, Hartmann W, Dirksen U, Gymrek M, Anderson ND, Shlien A, Rotblat B, Kirchner T, Delattre O, Grünewald TGP. Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes. Nat Commun. 2019 09 11; 10(1):4128.
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Robinson CM, Poon BPK, Kano Y, Pluthero FG, Kahr WHA, Ohh M. A Hypoxia-Inducible HIF1-GAL3ST1-Sulfatide Axis Enhances ccRCC Immune Evasion via Increased Tumor Cell-Platelet Binding. Mol Cancer Res. 2019 11; 17(11):2306-2317.
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Kemaladewi DU, Bassi PS, Erwood S, Al-Basha D, Gawlik KI, Lindsay K, Hyatt E, Kember R, Place KM, Marks RM, Durbeej M, Prescott SA, Ivakine EA, Cohn RD. A mutation-independent approach for muscular dystrophy via upregulation of a modifier gene. Nature. 2019 08; 572(7767):125-130.
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Leão R, Lee D, Figueiredo A, Hermanns T, Wild P, Komosa M, Lau I, Mistry M, Nunes NM, Price AJ, Zhang C, Lipman T, Poyet C, Valtcheva N, Oehl K, Coelho H, Sayyid R, Gomes AM, Prado E Castro L, Sweet J, Vinagre J, Apolónio J, Stephens D, Faleiro I, Fadaak K, Richard PO, Kulkarni G, Zlotta AR, Hamilton RJ, Castelo-Branco P, Tabori U. Combined genetic and epigenetic alterations of the TERT promoter affect clinical and biological behavior of bladder cancer. Int J Cancer. 2019 04 01; 144(7):1676-1684.
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Morena M, Aukema RJ, Leitl KD, Rashid AJ, Vecchiarelli HA, Josselyn SA, Hill MN. Upregulation of Anandamide Hydrolysis in the Basolateral Complex of Amygdala Reduces Fear Memory Expression and Indices of Stress and Anxiety. J Neurosci. 2019 02 13; 39(7):1275-1292.
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Pilecki B, Wulf-Johansson H, Støttrup C, Jørgensen PT, Djiadeu P, Nexøe AB, Schlosser A, Hansen SWK, Madsen J, Clark HW, Nielsen CH, Vestbo J, Palaniyar N, Holmskov U, Sorensen GL. Surfactant Protein D Deficiency Aggravates Cigarette Smoke-Induced Lung Inflammation by Upregulation of Ceramide Synthesis. Front Immunol. 2018; 9:3013.
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Bakhshinyan D, Venugopal C, Adile AA, Garg N, Manoranjan B, Hallett R, Wang X, Mahendram S, Vora P, Vijayakumar T, Subapanditha M, Singh M, Kameda-Smith MM, Qazi M, McFarlane N, Mann A, Ajani OA, Yarascavitch B, Ramaswamy V, Farooq H, Morrissy S, Cao L, Sydorenko N, Baiazitov R, Du W, Sheedy J, Weetall M, Moon YC, Lee CS, Kwiecien JM, Delaney KH, Doble B, Cho YJ, Mitra S, Kaplan D, Taylor MD, Davis TW, Singh SK. BMI1 is a therapeutic target in recurrent medulloblastoma. Oncogene. 2019 03; 38(10):1702-1716.
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Wei Y, Maximov V, Morrissy SA, Taylor MD, Pallas DC, Kenney AM. p53 Function Is Compromised by Inhibitor 2 of Phosphatase 2A in Sonic Hedgehog Medulloblastoma. Mol Cancer Res. 2019 01; 17(1):186-198.
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Jaeger-Lansky A, Schmidthaler K, Kuessel L, Gstöttner M, Waidhofer-Söllner P, Zlabinger GJ, Wenzl R, Eiwegger T. Local and systemic levels of cytokines and danger signals in endometriosis-affected women. J Reprod Immunol. 2018 11; 130:7-10.
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