 Structure-Activity Relationship
"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
| Descriptor ID |
D013329
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| MeSH Number(s) |
G02.111.830 G07.690.773.997
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| Concept/Terms |
Structure-Activity Relationship- Structure-Activity Relationship
- Relationship, Structure-Activity
- Relationships, Structure-Activity
- Structure Activity Relationship
- Structure-Activity Relationships
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Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".
Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".
This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 0 | 1 | 1 | | 1981 | 0 | 1 | 1 | | 1982 | 0 | 1 | 1 | | 1984 | 0 | 1 | 1 | | 1985 | 0 | 3 | 3 | | 1986 | 0 | 3 | 3 | | 1987 | 0 | 2 | 2 | | 1988 | 0 | 3 | 3 | | 1989 | 0 | 3 | 3 | | 1990 | 0 | 1 | 1 | | 1991 | 0 | 2 | 2 | | 1992 | 0 | 3 | 3 | | 1993 | 0 | 4 | 4 | | 1994 | 0 | 8 | 8 | | 1995 | 0 | 4 | 4 | | 1996 | 0 | 5 | 5 | | 1997 | 0 | 2 | 2 | | 1998 | 0 | 2 | 2 | | 1999 | 0 | 3 | 3 | | 2000 | 0 | 2 | 2 | | 2001 | 0 | 3 | 3 | | 2002 | 0 | 3 | 3 | | 2003 | 0 | 7 | 7 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 2 | 2 | | 2006 | 0 | 10 | 10 | | 2008 | 0 | 2 | 2 | | 2009 | 0 | 5 | 5 | | 2010 | 1 | 4 | 5 | | 2011 | 0 | 4 | 4 | | 2012 | 0 | 2 | 2 | | 2013 | 0 | 7 | 7 | | 2014 | 0 | 5 | 5 | | 2015 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2017 | 0 | 3 | 3 | | 2018 | 0 | 4 | 4 |
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Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.
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Fischer NW, Prodeus A, Tran J, Malkin D, Gariépy J. Association Between the Oligomeric Status of p53 and Clinical Outcomes in Li-Fraumeni Syndrome. J Natl Cancer Inst. 2018 12 01; 110(12):1418-1421.
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Guo H, Rubinstein JL. Cryo-EM of ATP synthases. Curr Opin Struct Biol. 2018 10; 52:71-79.
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Roston TM, Yuchi Z, Kannankeril PJ, Hathaway J, Vinocur JM, Etheridge SP, Potts JE, Maginot KR, Salerno JC, Cohen MI, Hamilton RM, Pflaumer A, Mohammed S, Kimlicka L, Kanter RJ, LaPage MJ, Collins KK, Gebauer RA, Temple JD, Batra AS, Erickson C, Miszczak-Knecht M, Kubuš P, Bar-Cohen Y, Kantoch M, Thomas VC, Hessling G, Anderson C, Young ML, Choi SHJ, Cabrera Ortega M, Lau YR, Johnsrude CL, Fournier A, Van Petegem F, Sanatani S. The clinical and genetic spectrum of catecholaminergic polymorphic ventricular tachycardia: findings from an international multicentre registry. Europace. 2018 03 01; 20(3):541-547.
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Chang YH, Stone TA, Chin S, Glibowicka M, Bear CE, Deber CM. Structural effects of extracellular loop mutations in CFTR helical hairpins. Biochim Biophys Acta Biomembr. 2018 May; 1860(5):1092-1098.
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Alniss H, Zamiri B, Khalaj M, Pearson CE, Macgregor RB. Thermodynamic and spectroscopic investigations of TMPyP4 association with guanine- and cytosine-rich DNA and RNA repeats of C9orf72. Biochem Biophys Res Commun. 2018 Jan 22; 495(4):2410-2417.
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Wang S, Juan J, Zhang Z, Du Y, Xu Y, Tong J, Cao B, Moran MF, Zeng Y, Mao X. Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis. Cell Death Dis. 2017 09 21; 8(9):e3058.
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Saito T, Bokhove M, Croci R, Zamora-Caballero S, Han L, Letarte M, de Sanctis D, Jovine L. Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1. Cell Rep. 2017 05 30; 19(9):1917-1928.
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Wang TF, Dawson JE, Forman-Kay JD, Kahr WHA, Williams S, Chan AK, Kumar R. Molecular structural analysis of a novel and de-novo mutation in the SERPINC1 gene associated with type 1 antithrombin deficiency. Br J Haematol. 2017 05; 177(4):654-656.
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Tropak MB, Zhang J, Yonekawa S, Rigat BA, Aulakh VS, Smith MR, Hwang HJ, Ciufolini MA, Mahuran DJ. Pyrimethamine Derivatives: Insight into Binding Mechanism and Improved Enhancement of Mutant ß-N-acetylhexosaminidase Activity. J Med Chem. 2015 Jun 11; 58(11):4483-93.
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Bernatchez JA, Paul R, Tchesnokov EP, Ngure M, Beilhartz GL, Berghuis AM, Lavoie R, Li L, Auger A, Melnyk RA, Grobler JA, Miller MD, Hazuda DJ, Hecht SM, Götte M. Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase. J Biol Chem. 2015 Jan 16; 290(3):1474-84.
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