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Spencer Freeman

TitleScientist
InstitutionThe Hospital for Sick Children
DepartmentResearch Operations
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ostrowski PP, Freeman SA, Fairn G, Grinstein S. Dynamic Podosome-Like Structures in Nascent Phagosomes Are Coordinated by Phosphoinositides. Dev Cell. 2019 Jun 06. PMID: 31231039.
      View in: PubMed
    2. Marques PE, Nyegaard S, Collins RF, Troise F, Freeman SA, Trimble WS, Grinstein S. Multimerization and Retention of the Scavenger Receptor SR-B1 in the Plasma Membrane. Dev Cell. 2019 Jun 04. PMID: 31231038.
      View in: PubMed
    3. Freeman SA, Grinstein S. Resolution of macropinosomes, phagosomes and autolysosomes: Osmotically driven shrinkage enables tubulation and vesiculation. Traffic. 2018 12; 19(12):965-974. PMID: 30159984.
      View in: PubMed
    4. Mylvaganam SM, Grinstein S, Freeman SA. Picket-fences in the plasma membrane: functions in immune cells and phagocytosis. Semin Immunopathol. 2018 11; 40(6):605-615. PMID: 30209546.
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    5. Vega AR, Freeman SA, Grinstein S, Jaqaman K. Multistep Track Segmentation and Motion Classification for Transient Mobility Analysis. Biophys J. 2018 03 13; 114(5):1018-1025. PMID: 29539390.
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    6. Jochmans S, Mazerand S, Mercier des Rochettes E, Abdallah RI, Freeman SA, Monchi M. Reverse triggering with breath stacking in ARDS patients: the "optimum" can be the enemy of the "good". Minerva Anestesiol. 2018 Jul; 84(7):871-872. PMID: 29469546.
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    7. Freeman SA, Vega A, Riedl M, Collins RF, Ostrowski PP, Woods EC, Bertozzi CR, Tammi MI, Lidke DS, Johnson P, Mayor S, Jaqaman K, Grinstein S. Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement. Cell. 2018 01 11; 172(1-2):305-317.e10. PMID: 29328918.
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    8. Schlam D, Grinstein S, Freeman SA. Screening for Rho GTPase Modulators in Actin-Dependent Processes Exemplified by Phagocytosis. Methods Mol Biol. 2018; 1821:107-127. PMID: 30062408.
      View in: PubMed
    9. Thetiot M, Freeman SA, Desmazières A. Immunohistochemical Analysis of Myelin Structures. Methods Mol Biol. 2018; 1791:15-23. PMID: 30006698.
      View in: PubMed
    10. Sharfe N, Karanxha A, Dadi H, Merico D, Chitayat D, Herbrick JA, Freeman S, Grinstein S, Roifman CM. Dual loss of p110d PI3-kinase and SKAP (KNSTRN) expression leads to combined immunodeficiency and multisystem syndromic features. J Allergy Clin Immunol. 2018 Aug; 142(2):618-629. PMID: 29180244.
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    11. Marques PE, Grinstein S, Freeman SA. SnapShot:Macropinocytosis. Cell. 2017 05 04; 169(4):766-766.e1. PMID: 28475901.
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    12. Wang JC, Lee JY, Christian S, Dang-Lawson M, Pritchard C, Freeman SA, Gold MR. The Rap1-cofilin-1 pathway coordinates actin reorganization and MTOC polarization at the B cell immune synapse. J Cell Sci. 2017 03 15; 130(6):1094-1109. PMID: 28167682.
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    13. Hua R, Cheng D, Coyaud É, Freeman S, Di Pietro E, Wang Y, Vissa A, Yip CM, Fairn GD, Braverman N, Brumell JH, Trimble WS, Raught B, Kim PK. VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis. J Cell Biol. 2017 02; 216(2):367-377. PMID: 28108526.
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    14. Freeman SA, Grinstein S. Phagocytosis: How Macrophages Tune Their Non-professional Counterparts. Curr Biol. 2016 12 19; 26(24):R1279-R1282. PMID: 27997839.
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    15. Saric A, Grinstein S, Freeman SA. Measurement of Autolysosomal pH by Dual-Wavelength Ratio Imaging. Methods Enzymol. 2017; 588:15-29. PMID: 28237098.
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    16. Spencer JM, Freeman SA. Microneedling Prior to Levulan PDT for the Treatment of Actinic Keratoses: A Split-Face, Blinded Trial. J Drugs Dermatol. 2016 Sep 01; 15(9):1072-4. PMID: 27602968.
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    17. Ostrowski PP, Grinstein S, Freeman SA. Diffusion Barriers, Mechanical Forces, and the Biophysics of Phagocytosis. Dev Cell. 2016 07 25; 38(2):135-46. PMID: 27459066.
      View in: PubMed
    18. Freeman SA. Criminal Forensic Psychiatry: A Primer for Psychiatrists. J Clin Psychiatry. 2016 06; 77(6):e745. PMID: 27337424.
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    19. Freeman SA, Christian S, Austin P, Iu I, Graves ML, Huang L, Tang S, Coombs D, Gold MR, Roskelley CD. Applied stretch initiates directional invasion through the action of Rap1 GTPase as a tension sensor. J Cell Sci. 2017 01 01; 130(1):152-163. PMID: 27199371.
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    20. Schlam D, Canton J, Carreño M, Kopinski H, Freeman SA, Grinstein S, Fairn GD. Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,4,5-Trisphosphate Homeostasis. MBio. 2016 Apr 05; 7(2):e02242. PMID: 27048806.
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    21. Oudhoff MJ, Braam MJS, Freeman SA, Wong D, Rattray DG, Wang J, Antignano F, Snyder K, Refaeli I, Hughes MR, McNagny KM, Gold MR, Arrowsmith CH, Sato T, Rossi FMV, Tatlock JH, Owen DR, Brown PJ, Zaph C. SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/ß-Catenin and Hippo/YAP Signaling. Dev Cell. 2016 Apr 04; 37(1):47-57. PMID: 27046831.
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    22. Wong HS, Jaumouillé V, Freeman SA, Doodnauth SA, Schlam D, Canton J, Mukovozov IM, Saric A, Grinstein S, Robinson LA. Chemokine Signaling Enhances CD36 Responsiveness toward Oxidized Low-Density Lipoproteins and Accelerates Foam Cell Formation. Cell Rep. 2016 Mar 29; 14(12):2859-71. PMID: 26997267.
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    23. Freeman SA, Goyette J, Furuya W, Woods EC, Bertozzi CR, Bergmeier W, Hinz B, van der Merwe PA, Das R, Grinstein S. Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis. Cell. 2016 Jan 14; 164(1-2):128-140. PMID: 26771488.
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    24. Neeley AR, Freeman SA, Harris LA. Multi-method approach to quantify uncertainties in the measurements of light absorption by particles. Opt Express. 2015 Nov 30; 23(24):31043-58. PMID: 26698734.
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    25. Freeman SA, Desmazières A, Fricker D, Lubetzki C, Sol-Foulon N. Mechanisms of sodium channel clustering and its influence on axonal impulse conduction. Cell Mol Life Sci. 2016 Feb; 73(4):723-35. PMID: 26514731.
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    26. Schlam D, Bagshaw RD, Freeman SA, Collins RF, Pawson T, Fairn GD, Grinstein S. Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins. Nat Commun. 2015 Oct 14; 6:8623. PMID: 26465210.
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    27. Freeman SA, Jaumouillé V, Choi K, Hsu BE, Wong HS, Abraham L, Graves ML, Coombs D, Roskelley CD, Das R, Grinstein S, Gold MR. Erratum: Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor. Nat Commun. 2015 Apr 17; 6:7015. PMID: 25881569.
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    28. Freeman SA, Jaumouillé V, Choi K, Hsu BE, Wong HS, Abraham L, Graves ML, Coombs D, Roskelley CD, Das R, Grinstein S, Gold MR. Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor. Nat Commun. 2015 Feb 03; 6:6168. PMID: 25644899.
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    29. Freeman SA, Desmazières A, Simonnet J, Gatta M, Pfeiffer F, Aigrot MS, Rappeneau Q, Guerreiro S, Michel PP, Yanagawa Y, Barbin G, Brophy PJ, Fricker D, Lubetzki C, Sol-Foulon N. Acceleration of conduction velocity linked to clustering of nodal components precedes myelination. Proc Natl Acad Sci U S A. 2015 Jan 20; 112(3):E321-8. PMID: 25561543.
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    30. Schwind KS, Freeman SA, Garcia M, Roberts R. Manic Monday to fabulous Friday: partnering to improve behavioral and mental health needs of students. NASN Sch Nurse. 2015 Jan; 30(1):35-8. PMID: 25626241.
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    31. Freeman SA, Grinstein S. Phagocytosis: receptors, signal integration, and the cytoskeleton. Immunol Rev. 2014 Nov; 262(1):193-215. PMID: 25319336.
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    32. Barsyte-Lovejoy D, Li F, Oudhoff MJ, Tatlock JH, Dong A, Zeng H, Wu H, Freeman SA, Schapira M, Senisterra GA, Kuznetsova E, Marcellus R, Allali-Hassani A, Kennedy S, Lambert JP, Couzens AL, Aman A, Gingras AC, Al-Awar R, Fish PV, Gerstenberger BS, Roberts L, Benn CL, Grimley RL, Braam MJ, Rossi FM, Sudol M, Brown PJ, Bunnage ME, Owen DR, Zaph C, Vedadi M, Arrowsmith CH. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):12853-8. PMID: 25136132.
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    33. Mosher GA, Keren N, Freeman SA, Hurburgh CR. Development of a safety decision-making scenario to measure worker safety in agriculture. J Agric Saf Health. 2014 Apr; 20(2):91-107. PMID: 24897917.
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    34. Oudhoff MJ, Freeman SA, Couzens AL, Antignano F, Kuznetsova E, Min PH, Northrop JP, Lehnertz B, Barsyte-Lovejoy D, Vedadi M, Arrowsmith CH, Nishina H, Gold MR, Rossi FM, Gingras AC, Zaph C. Control of the hippo pathway by Set7-dependent methylation of Yap. Dev Cell. 2013 Jul 29; 26(2):188-94. PMID: 23850191.
      View in: PubMed
    35. Freeman SA. Iloperidone-induced retrograde ejaculation. Int Clin Psychopharmacol. 2013 May; 28(3):156. PMID: 23385360.
      View in: PubMed
    36. Mosher GA, Keren N, Freeman SA, Hurburgh CR. Measurement of worker perceptions of trust and safety climate in managers and supervisors at commercial grain elevators. J Agric Saf Health. 2013 Apr; 19(2):125-34. PMID: 23923732.
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    37. Freeman SA, Rosenbluth B, Cotton L. Teen dating abuse: recognition and interventions. NASN Sch Nurse. 2013 Mar; 28(2):79-82. PMID: 23600090.
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    38. Austin P, Freeman SA, Gray CA, Gold MR, Vogl AW, Andersen RJ, Roberge M, Roskelley CD. The invasion inhibitor sarasinoside A1 reverses mesenchymal tumor transformation in an E-cadherin-independent manner. Mol Cancer Res. 2013 May; 11(5):530-40. PMID: 23399642.
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    39. Freeman SA, Moon SD, Spencer JM. Clindamycin phosphate 1.2% and tretinoin 0.025% gel for rosacea: summary of a placebo-controlled, double-blind trial. J Drugs Dermatol. 2012 Dec; 11(12):1410-4. PMID: 23377509.
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    40. Mosher GA, Keren N, Freeman SA, Hurburgh CR. Management of safety and quality and the relationship with employee decisions in country grain elevators. J Agric Saf Health. 2012 Jul; 18(3):195-215. PMID: 22900433.
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    41. Freeman SA, Lei V, Dang-Lawson M, Mizuno K, Roskelley CD, Gold MR. Cofilin-mediated F-actin severing is regulated by the Rap GTPase and controls the cytoskeletal dynamics that drive lymphocyte spreading and BCR microcluster formation. J Immunol. 2011 Dec 01; 187(11):5887-900. PMID: 22068232.
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    42. Maltby S, Freeman S, Gold MJ, Baker JH, Minchinton AI, Gold MR, Roskelley CD, McNagny KM. Opposing roles for CD34 in B16 melanoma tumor growth alter early stage vasculature and late stage immune cell infiltration. PLoS One. 2011 Apr 11; 6(4):e18160. PMID: 21494591.
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    43. Lin KB, Freeman SA, Gold MR. Rap GTPase-mediated adhesion and migration: A target for limiting the dissemination of B-cell lymphomas? Cell Adh Migr. 2010 Jul-Sep; 4(3):327-32. PMID: 20212359.
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    44. Freeman SA, McLeod SJ, Dukowski J, Austin P, Lee CC, Millen-Martin B, Kubes P, McCafferty DM, Gold MR, Roskelley CD. Preventing the activation or cycling of the Rap1 GTPase alters adhesion and cytoskeletal dynamics and blocks metastatic melanoma cell extravasation into the lungs. Cancer Res. 2010 Jun 01; 70(11):4590-601. PMID: 20484042.
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    45. Lin KB, Freeman SA, Zabetian S, Brugger H, Weber M, Lei V, Dang-Lawson M, Tse KW, Santamaria R, Batista FD, Gold MR. The rap GTPases regulate B cell morphology, immune-synapse formation, and signaling by particulate B cell receptor ligands. Immunity. 2008 Jan; 28(1):75-87. PMID: 18191594.
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    46. Badour K, McGavin MK, Zhang J, Freeman S, Vieira C, Filipp D, Julius M, Mills GB, Siminovitch KA. Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells. Proc Natl Acad Sci U S A. 2007 Jan 30; 104(5):1593-8. PMID: 17242350.
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    47. Leng Y, Zhang J, Badour K, Arpaia E, Freeman S, Cheung P, Siu M, Siminovitch K. Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation. Proc Natl Acad Sci U S A. 2005 Jan 25; 102(4):1098-103. PMID: 15657136.
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