Polymerase Chain Reaction
"Polymerase Chain Reaction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Descriptor ID |
D016133
|
MeSH Number(s) |
E05.393.620.500
|
Concept/Terms |
Polymerase Chain Reaction- Polymerase Chain Reaction
- Polymerase Chain Reactions
- Reaction, Polymerase Chain
- Reactions, Polymerase Chain
- PCR
Inverse PCR- Inverse PCR
- PCR, Inverse
- Inverse Polymerase Chain Reaction
Anchored PCR- Anchored PCR
- PCR, Anchored
- Anchored Polymerase Chain Reaction
|
Below are MeSH descriptors whose meaning is more general than "Polymerase Chain Reaction".
Below are MeSH descriptors whose meaning is more specific than "Polymerase Chain Reaction".
This graph shows the total number of publications written about "Polymerase Chain Reaction" by people in this website by year, and whether "Polymerase Chain Reaction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
---|
1989 | 0 | 1 | 1 | 1990 | 0 | 7 | 7 | 1991 | 0 | 6 | 6 | 1992 | 0 | 12 | 12 | 1993 | 0 | 12 | 12 | 1994 | 1 | 14 | 15 | 1995 | 2 | 18 | 20 | 1996 | 1 | 22 | 23 | 1997 | 2 | 24 | 26 | 1998 | 0 | 18 | 18 | 1999 | 3 | 12 | 15 | 2000 | 2 | 9 | 11 | 2001 | 1 | 6 | 7 | 2002 | 0 | 8 | 8 | 2003 | 2 | 6 | 8 | 2004 | 1 | 7 | 8 | 2005 | 1 | 8 | 9 | 2006 | 2 | 11 | 13 | 2007 | 2 | 18 | 20 | 2008 | 0 | 10 | 10 | 2009 | 1 | 11 | 12 | 2010 | 1 | 9 | 10 | 2011 | 1 | 13 | 14 | 2012 | 0 | 6 | 6 | 2013 | 0 | 7 | 7 | 2014 | 1 | 5 | 6 | 2015 | 1 | 6 | 7 | 2016 | 3 | 6 | 9 | 2017 | 0 | 1 | 1 | 2018 | 0 | 2 | 2 | 2019 | 1 | 2 | 3 | 2020 | 0 | 2 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Polymerase Chain Reaction" by people in Profiles.
-
Di Scipio M, Tavares E, Deshmukh S, Audo I, Green-Sanderson K, Zubak Y, Zine-Eddine F, Pearson A, Vig A, Tang CY, Mollica A, Karas J, Tumber A, Yu CW, Billingsley G, Wilson MD, Zeitz C, Héon E, Vincent A. Phenotype Driven Analysis of Whole Genome Sequencing Identifies Deep Intronic Variants that Cause Retinal Dystrophies by Aberrant Exonization. Invest Ophthalmol Vis Sci. 2020 08 03; 61(10):36.
-
Ryall S, Tabori U, Hawkins C. Pediatric low-grade glioma in the era of molecular diagnostics. Acta Neuropathol Commun. 2020 03 12; 8(1):30.
-
van Kuilenburg ABP, Tarailo-Graovac M, Richmond PA, Drögemöller BI, Pouladi MA, Leen R, Brand-Arzamendi K, Dobritzsch D, Dolzhenko E, Eberle MA, Hayward B, Jones MJ, Karbassi F, Kobor MS, Koster J, Kumari D, Li M, MacIsaac J, McDonald C, Meijer J, Nguyen C, Rajan-Babu IS, Scherer SW, Sim B, Trost B, Tseng LA, Turkenburg M, van Vugt JJFA, Veldink JH, Walia JS, Wang Y, van Weeghel M, Wright GEB, Xu X, Yuen RKC, Zhang J, Ross CJ, Wasserman WW, Geraghty MT, Santra S, Wanders RJA, Wen XY, Waterham HR, Usdin K, van Karnebeek CDM. Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS. N Engl J Med. 2019 04 11; 380(15):1433-1441.
-
Rossant J, Nagy A. Preparation of Polymerase Chain Reaction Templates from Embryonic and Adult Mouse Tissue Samples. Cold Spring Harb Protoc. 2019 03 01; 2019(3).
-
Clark ST, Sinha U, Zhang Y, Wang PW, Donaldson SL, Coburn B, Waters VJ, Yau YCW, Tullis DE, Guttman DS, Hwang DM. Penicillin-binding protein 3 is a common adaptive target among Pseudomonas aeruginosa isolates from adult cystic fibrosis patients treated with ß-lactams. Int J Antimicrob Agents. 2019 May; 53(5):620-628.
-
Rahman MZ, Sumiya M, Sahabuddin M, Pell LG, Gubbay JB, Rahman R, Momtaz F, Azmuda N, Shanta SS, Jahan I, Rahman M, Mahmud AA, Roth DE, Morris SK. Genetic characterization of human metapneumovirus identified through community and facility-based surveillance of infants in Dhaka, Bangladesh. J Med Virol. 2019 04; 91(4):549-554.
-
Laetsch TW, Maude SL, Milone MC, Davis KL, Krueger J, Cardenas AM, Eldjerou LK, Keir CH, Wood PA, Grupp SA. False-positive results with select HIV-1 NAT methods following lentivirus-based tisagenlecleucel therapy. Blood. 2018 06 07; 131(23):2596-2598.
-
Lee C, Minich A, Li B, Miyake H, Seo S, Pierro A. Influence of stress factors on intestinal epithelial injury and regeneration. Pediatr Surg Int. 2018 Feb; 34(2):155-160.
-
Finkelstein Y, Blonquist TM, Vijayanathan V, Stevenson KE, Neuberg DS, Silverman LB, Vrooman LM, Sallan SE, Cole PD. A thymidylate synthase polymorphism is associated with increased risk for bone toxicity among children treated for acute lymphoblastic leukemia. Pediatr Blood Cancer. 2017 Jul; 64(7).
-
Chen Y, Koike Y, Miyake H, Li B, Lee C, Hock A, Zani A, Pierro A. Formula feeding and systemic hypoxia synergistically induce intestinal hypoxia in experimental necrotizing enterocolitis. Pediatr Surg Int. 2016 Dec; 32(12):1115-1119.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|