 Signal Transduction
"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
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| MeSH Number(s) |
G02.111.087.800 G02.149.115.800 G04.299.880
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| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
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Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 2 | 0 | 2 | | 1991 | 2 | 3 | 5 | | 1992 | 1 | 3 | 4 | | 1993 | 3 | 7 | 10 | | 1994 | 6 | 9 | 15 | | 1995 | 7 | 14 | 21 | | 1996 | 3 | 12 | 15 | | 1997 | 6 | 11 | 17 | | 1998 | 10 | 13 | 23 | | 1999 | 9 | 17 | 26 | | 2000 | 7 | 12 | 19 | | 2001 | 13 | 18 | 31 | | 2002 | 7 | 16 | 23 | | 2003 | 17 | 27 | 44 | | 2004 | 11 | 17 | 28 | | 2005 | 15 | 26 | 41 | | 2006 | 19 | 31 | 50 | | 2007 | 16 | 26 | 42 | | 2008 | 19 | 19 | 38 | | 2009 | 18 | 30 | 48 | | 2010 | 16 | 29 | 45 | | 2011 | 15 | 41 | 56 | | 2012 | 18 | 41 | 59 | | 2013 | 19 | 34 | 53 | | 2014 | 19 | 52 | 71 | | 2015 | 17 | 33 | 50 | | 2016 | 15 | 31 | 46 | | 2017 | 10 | 38 | 48 | | 2018 | 11 | 28 | 39 | | 2019 | 1 | 2 | 3 |
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Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Tao H, Zhu M, Lau K, Whitley OKW, Samani M, Xiao X, Chen XX, Hahn NA, Liu W, Valencia M, Wu M, Wang X, Fenelon KD, Pasiliao CC, Hu D, Wu J, Spring S, Ferguson J, Karuna EP, Henkelman RM, Dunn A, Huang H, Ho HH, Atit R, Goyal S, Sun Y, Hopyan S. Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch. Nat Commun. 2019 04 12; 10(1):1703.
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Walters BJ, Josselyn SA. Retinoic acid receptor plays both sides of homeostatic plasticity. Proc Natl Acad Sci U S A. 2019 04 02; 116(14):6528-6530.
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Rajakulendran N, Rowland KJ, Selvadurai HJ, Ahmadi M, Park NI, Naumenko S, Dolma S, Ward RJ, So M, Lee L, MacLeod G, Pasiliao C, Brandon C, Clarke ID, Cusimano MD, Bernstein M, Batada N, Angers S, Dirks PB. Wnt and Notch signaling govern self-renewal and differentiation in a subset of human glioblastoma stem cells. Genes Dev. 2019 05 01; 33(9-10):498-510.
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Bertrand KC, Faria CC, Skowron P, Luck A, Garzia L, Wu X, Agnihotri S, Smith CA, Taylor MD, Mack SC, Rutka JT. A functional genomics approach to identify pathways of drug resistance in medulloblastoma. Acta Neuropathol Commun. 2018 12 27; 6(1):146.
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Alvares D, Hoffman S, Stankovic B, Adeli K. Gut peptide and neuroendocrine regulation of hepatic lipid and lipoprotein metabolism in health and disease. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 03; 1864(3):326-334.
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Lambert JP, Picaud S, Fujisawa T, Hou H, Savitsky P, Uusküla-Reimand L, Gupta GD, Abdouni H, Lin ZY, Tucholska M, Knight JDR, Gonzalez-Badillo B, St-Denis N, Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P, Gingras AC. Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Mol Cell. 2019 02 07; 73(3):621-638.e17.
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Scott BM, Chen SK, Bhattacharyya N, Moalim AY, Plotnikov SV, Heon E, Peisajovich SG, Chang BSW. Coupling of Human Rhodopsin to a Yeast Signaling Pathway Enables Characterization of Mutations Associated with Retinal Disease. Genetics. 2019 02; 211(2):597-615.
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Gibb N, Lazic S, Yuan X, Deshwar AR, Leslie M, Wilson MD, Scott IC. Hey2 regulates the size of the cardiac progenitor pool during vertebrate heart development. Development. 2018 11 21; 145(22).
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Hui CW, Song X, Ma F, Shen X, Herrup K. Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice. J Neuroinflammation. 2018 Nov 06; 15(1):308.
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Kahn SA, Wang X, Nitta RT, Gholamin S, Theruvath J, Hutter G, Azad TD, Wadi L, Bolin S, Ramaswamy V, Esparza R, Liu KW, Edwards M, Swartling FJ, Sahoo D, Li G, Wechsler-Reya RJ, Reimand J, Cho YJ, Taylor MD, Weissman IL, Mitra SS, Cheshier SH. Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma. Nat Commun. 2018 10 08; 9(1):4121.
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