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Gabrielle Boulianne

TitleSenior Scientist
InstitutionThe Hospital for Sick Children
DepartmentResearch Operations
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
ORCID ORCID Icon0000-0002-2964-2344 Additional info
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    Collapse Biography 
    Collapse education and training
    McGill University, Montreal, CanadaB.Sc.1982Biology; Genetics
    University of Toronto, Toronto, CanadaPh.D.1988Med.Biophysics
    Collapse awards and honors
    2015 - 2015Presidents Award of Excellence, The Hospital for Sick Children
    2005 - 2019Canada Research Chair in Mol. Dev. Neurobiology (Tier I)
    2001 - 2001TLL Temple Foundation Discovery Award , Alzheimers Association USA
    2000 - 2000Young Scientist Award , Genetics Society of Canada
    2000 - 2005Investigator Award, CIHR
    1997 - 1997Ruth Salta Young Investigator Award , American Health Assistance Foundation
    1988 - 1990Postdoctoral Fellowship Award, National Cancer Institute of Canada
    1982 - 1988Graduate Studentship Award, National Cancer Institute of Canada
    1985 - 1985Alan Wu Research Award, The University of Toronto

    Collapse Overview 
    Collapse overview
    My colleagues and I are interested in understanding how cell fate is determined during neuronal development in Drosophila . In recent years we have focused on a group of genes, called "neurogenic genes", which have been shown to interact in a common pathway to determine the fate of virtually every cell type in many complex organisms. A second area of research is to understand the molecular basis of neurotransmitter release. Using genetic and molecular approaches we have identified and characterized the function of the NSF gene which plays a central role in this process. Finally, we are also developing Drosophila models of aging and neurodegenerative disease. This work involves the analysis of SOD and presenilins for which mutations have been implicated in Amyotrophic Lateral Sclerosis and Alzheimers Disease, respectively.


    Collapse Research 
    Collapse research activities and funding
         (Gabrielle Boulianne)
    CIHR Operating Grant
    Evaluating the Therapeutic Potential of ACE inhibitors in AD

         (Gabrielle Boulianne)
    CIHR Operating Grants
    Identification and Characterization of Genes Regulating Lifespan in Drosophila

         (Gabrielle Boulianne)
    CIHR Operating Grant
    Drosophila Models of Human Obesity

         (Gabrielle Boulianne)
    NSERC Discovery Grant
    Cell-Cell Interactions During Drosophila Development

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wasserman SS, Shteiman-Kotler A, Harris K, Iliadi KG, Persaud A, Zhong Y, Zhang Y, Fang X, Boulianne GL, Stewart B, Rotin D. Regulation of SH3PX1 by dNedd4-long at the Drosophila neuromuscular junction. J Biol Chem. 2019 02 01; 294(5):1739-1752. PMID: 30518551.
      View in: PubMed
    2. Trinh I, Gluscencova OB, Boulianne GL. An in vivo screen for neuronal genes involved in obesity identifies Diacylglycerol kinase as a regulator of insulin secretion. Mol Metab. 2019 01; 19:13-23. PMID: 30389349.
      View in: PubMed
    3. Iliadi KG, Gluscencova OB, Iliadi N, Boulianne GL. Mutations in the Drosophila homolog of human PLA2G6 give rise to age-dependent loss of psychomotor activity and neurodegeneration. Sci Rep. 2018 02 13; 8(1):2939. PMID: 29440694.
      View in: PubMed
    4. Iliadi KG, Iliadi N, Boulianne GL. Drosophila mutants lacking octopamine exhibit impairment in aversive olfactory associative learning. Eur J Neurosci. 2017 Sep; 46(5):2080-2087. PMID: 28715094.
      View in: PubMed
    5. Bonner JM, Boulianne GL. Diverse structures, functions and uses of FK506 binding proteins. Cell Signal. 2017 10; 38:97-105. PMID: 28652145.
      View in: PubMed
    6. Liu S, Boulianne GL. The NHR domains of Neuralized and related proteins: Beyond Notch signalling. Cell Signal. 2017 01; 29:62-68. PMID: 27751914.
      View in: PubMed
    7. Iliadi KG, Gluscencova OB, Boulianne GL. Psychomotor Behavior: A Practical Approach in Drosophila. Front Psychiatry. 2016; 7:153. PMID: 27630583.
      View in: PubMed
    8. Safi F, Shteiman-Kotler A, Zhong Y, Iliadi KG, Boulianne GL, Rotin D. Drosophila Nedd4-long reduces Amphiphysin levels in muscles and leads to impaired T-tubule formation. Mol Biol Cell. 2016 Mar 15; 27(6):907-18. PMID: 26823013.
      View in: PubMed
    9. Knight D, Iliadi KG, Iliadi N, Wilk R, Hu J, Krause HM, Taylor P, Moran MF, Boulianne GL. Distinct Regulation of Transmitter Release at the Drosophila NMJ by Different Isoforms of nemy. PLoS One. 2015; 10(8):e0132548. PMID: 26237434.
      View in: PubMed
    10. Xu H, Mohtashami M, Stewart B, Boulianne G, Trimble WS. Drosophila SNAP-29 is an essential SNARE that binds multiple proteins involved in membrane traffic. PLoS One. 2014; 9(3):e91471. PMID: 24626111.
      View in: PubMed
    11. Trinh I, Boulianne GL. Modeling obesity and its associated disorders in Drosophila. Physiology (Bethesda). 2013 Mar; 28(2):117-24. PMID: 23455770.
      View in: PubMed
    12. Su J, Chow B, Boulianne GL, Wilde A. The BAR domain of amphiphysin is required for cleavage furrow tip-tubule formation during cellularization in Drosophila embryos. Mol Biol Cell. 2013 May; 24(9):1444-53. PMID: 23447705.
      View in: PubMed
    13. Bonnay F, Cohen-Berros E, Hoffmann M, Kim SY, Boulianne GL, Hoffmann JA, Matt N, Reichhart JM. big bang gene modulates gut immune tolerance in Drosophila. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2957-62. PMID: 23378635.
      View in: PubMed
    14. van de Hoef DL, Bonner JM, Boulianne GL. FKBP14 is an essential gene that regulates Presenilin protein levels and Notch signaling in Drosophila. Development. 2013 Feb; 140(4):810-9. PMID: 23318643.
      View in: PubMed
    15. Liu S, Bonner JM, Chanet S, Commisso C, Skwarek LC, Schweisguth F, Boulianne GL. Functional analysis of the NHR2 domain indicates that oligomerization of Neuralized regulates ubiquitination and endocytosis of Delta during Notch signaling. Mol Cell Biol. 2012 Dec; 32(24):4933-45. PMID: 23045391.
      View in: PubMed
    16. Iliadi KG, Knight D, Boulianne GL. Healthy aging - insights from Drosophila. Front Physiol. 2012; 3:106. PMID: 22529821.
      View in: PubMed
    17. Borycz J, Borycz JA, Edwards TN, Boulianne GL, Meinertzhagen IA. The metabolism of histamine in the Drosophila optic lobe involves an ommatidial pathway: ß-alanine recycles through the retina. J Exp Biol. 2012 Apr 15; 215(Pt 8):1399-411. PMID: 22442379.
      View in: PubMed
    18. Zhong Y, Shtineman-Kotler A, Nguyen L, Iliadi KG, Boulianne GL, Rotin D. A splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila. PLoS One. 2011; 6(11):e27007. PMID: 22110599.
      View in: PubMed
    19. Knight D, Xie W, Boulianne GL. Neurexins and neuroligins: recent insights from invertebrates. Mol Neurobiol. 2011 Dec; 44(3):426-40. PMID: 22037798.
      View in: PubMed
    20. Leventis PA, Da Sylva TR, Rajwans N, Wasiak S, McPherson PS, Boulianne GL. Liquid facets-related (lqfR) is required for egg chamber morphogenesis during Drosophila oogenesis. PLoS One. 2011; 6(10):e25466. PMID: 22043285.
      View in: PubMed
    21. Burgess J, Jauregui M, Tan J, Rollins J, Lallet S, Leventis PA, Boulianne GL, Chang HC, Le Borgne R, Krämer H, Brill JA. AP-1 and clathrin are essential for secretory granule biogenesis in Drosophila. Mol Biol Cell. 2011 Jun 15; 22(12):2094-105. PMID: 21490149.
      View in: PubMed
    22. Sun M, Xing G, Yuan L, Gan G, Knight D, With SI, He C, Han J, Zeng X, Fang M, Boulianne GL, Xie W. Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction. J Neurosci. 2011 Jan 12; 31(2):687-99. PMID: 21228178.
      View in: PubMed
    23. Schachter H, Boulianne G. Life is sweet! A novel role for N-glycans in Drosophila lifespan. Fly (Austin). 2011 Jan-Mar; 5(1):18-24. PMID: 21057214.
      View in: PubMed
    24. Klose MK, Dason JS, Atwood HL, Boulianne GL, Mercier AJ. Peptide-induced modulation of synaptic transmission and escape response in Drosophila requires two G-protein-coupled receptors. J Neurosci. 2010 Nov 03; 30(44):14724-34. PMID: 21048131.
      View in: PubMed
    25. Bonner JM, Boulianne GL. Drosophila as a model to study age-related neurodegenerative disorders: Alzheimer's disease. Exp Gerontol. 2011 May; 46(5):335-9. PMID: 20719244.
      View in: PubMed
    26. Iliadi KG, Boulianne GL. Age-related behavioral changes in Drosophila. Ann N Y Acad Sci. 2010 Jun; 1197:9-18. PMID: 20536827.
      View in: PubMed
    27. Sarkar M, Iliadi KG, Leventis PA, Schachter H, Boulianne GL. Neuronal expression of Mgat1 rescues the shortened life span of Drosophila Mgat11 null mutants and increases life span. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9677-82. PMID: 20457894.
      View in: PubMed
    28. Knight D, Harvey PJ, Iliadi KG, Klose MK, Iliadi N, Dolezelova E, Charlton MP, Zurovec M, Boulianne GL. Equilibrative nucleoside transporter 2 regulates associative learning and synaptic function in Drosophila. J Neurosci. 2010 Apr 07; 30(14):5047-57. PMID: 20371825.
      View in: PubMed
    29. Michno K, Knight D, Campusano JM, Campussano JM, van de Hoef D, Boulianne GL. Intracellular calcium deficits in Drosophila cholinergic neurons expressing wild type or FAD-mutant presenilin. PLoS One. 2009 Sep 04; 4(9):e6904. PMID: 19730737.
      View in: PubMed
    30. Iliadi KG, Iliadi NN, Boulianne GL. Regulation of Drosophila life-span: effect of genetic background, sex, mating and social status. Exp Gerontol. 2009 Aug; 44(8):546-53. PMID: 19481597.
      View in: PubMed
    31. Klose MK, Boulianne GL, Robertson RM, Atwood HL. Role of ATP-dependent calcium regulation in modulation of Drosophila synaptic thermotolerance. J Neurophysiol. 2009 Aug; 102(2):901-13. PMID: 19474168.
      View in: PubMed
    32. van de Hoef DL, Hughes J, Livne-Bar I, Garza D, Konsolaki M, Boulianne GL. Identifying genes that interact with Drosophila presenilin and amyloid precursor protein. Genesis. 2009 Apr; 47(4):246-60. PMID: 19241393.
      View in: PubMed
    33. Skwarek LC, Boulianne GL. Great expectations for PIP: phosphoinositides as regulators of signaling during development and disease. Dev Cell. 2009 Jan; 16(1):12-20. PMID: 19154715.
      View in: PubMed
    34. Iliadi KG, Avivi A, Iliadi NN, Knight D, Korol AB, Nevo E, Taylor P, Moran MF, Kamyshev NG, Boulianne GL. nemy encodes a cytochrome b561 that is required for Drosophila learning and memory. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):19986-91. PMID: 19064935.
      View in: PubMed
    35. Skwarek LC, Garroni MK, Commisso C, Boulianne GL. Neuralized contains a phosphoinositide-binding motif required downstream of ubiquitination for delta endocytosis and notch signaling. Dev Cell. 2007 Dec; 13(6):783-95. PMID: 18061562.
      View in: PubMed
    36. Commisso C, Boulianne GL. The neuralized homology repeat 1 domain of Drosophila neuralized mediates nuclear envelope association and delta-dependent inhibition of nuclear import. J Mol Biol. 2008 Jan 25; 375(4):1125-40. PMID: 18076903.
      View in: PubMed
    37. Knight D, Iliadi K, Charlton MP, Atwood HL, Boulianne GL. Presynaptic plasticity and associative learning are impaired in a Drosophila presenilin null mutant. Dev Neurobiol. 2007 Oct; 67(12):1598-613. PMID: 17562530.
      View in: PubMed
    38. Mondal S, Ivanchuk SM, Rutka JT, Boulianne GL. Sloppy paired 1/2 regulate glial cell fates by inhibiting Gcm function. Glia. 2007 Feb; 55(3):282-93. PMID: 17091489.
      View in: PubMed
    39. Ing B, Shteiman-Kotler A, Castelli M, Henry P, Pak Y, Stewart B, Boulianne GL, Rotin D. Regulation of Commissureless by the ubiquitin ligase DNedd4 is required for neuromuscular synaptogenesis in Drosophila melanogaster. Mol Cell Biol. 2007 Jan; 27(2):481-96. PMID: 17074801.
      View in: PubMed
    40. Commisso C, Boulianne GL. The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling. Mol Biol Cell. 2007 Jan; 18(1):1-13. PMID: 17065551.
      View in: PubMed
    41. Cai C, Lin P, Cheung KH, Li N, Levchook C, Pan Z, Ferrante C, Boulianne GL, Foskett JK, Danielpour D, Ma J. The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosis. J Biol Chem. 2006 Jun 16; 281(24):16649-55. PMID: 16603547.
      View in: PubMed
    42. Sarkar M, Leventis PA, Silvescu CI, Reinhold VN, Schachter H, Boulianne GL. Null mutations in Drosophila N-acetylglucosaminyltransferase I produce defects in locomotion and a reduced life span. J Biol Chem. 2006 May 05; 281(18):12776-85. PMID: 16522637.
      View in: PubMed
    43. Kim SY, Renihan MK, Boulianne GL. Characterization of big bang, a novel gene encoding for PDZ domain-containing proteins that are dynamically expressed throughout Drosophila development. Gene Expr Patterns. 2006 Jun; 6(5):504-18. PMID: 16423565.
      View in: PubMed
    44. Snead OC, Clapcote SJ, Roder JC, Boulianne GL. Novel strategies for the development of animal models of refractory epilepsy. Adv Neurol. 2006; 97:155-71. PMID: 16383125.
      View in: PubMed
    45. Michno K, van de Hoef D, Wu H, Boulianne GL. Demented flies? Using Drosophila to model human neurodegenerative diseases. Clin Genet. 2005 Jun; 67(6):468-75. PMID: 15857410.
      View in: PubMed
    46. Michno K, van de Hoef D, Wu H, Boulianne GL. Modeling age-related diseases in Drosophila: can this fly? Curr Top Dev Biol. 2005; 71:199-223. PMID: 16344106.
      View in: PubMed
    47. Wasiak S, Denisov AY, Han Z, Leventis PA, de Heuvel E, Boulianne GL, Kay BK, Gehring K, McPherson PS. Characterization of a gamma-adaptin ear-binding motif in enthoprotin. FEBS Lett. 2003 Dec 18; 555(3):437-42. PMID: 14675752.
      View in: PubMed
    48. Xu H, Boulianne GL, Trimble WS. Drosophila syntaxin 16 is a Q-SNARE implicated in Golgi dynamics. J Cell Sci. 2002 Dec 01; 115(Pt 23):4447-55. PMID: 12414991.
      View in: PubMed
    49. Xu H, Brill JA, Hsien J, McBride R, Boulianne GL, Trimble WS. Syntaxin 5 is required for cytokinesis and spermatid differentiation in Drosophila. Dev Biol. 2002 Nov 15; 251(2):294-306. PMID: 12435359.
      View in: PubMed
    50. Bhattacharya S, Stewart BA, Niemeyer BA, Burgess RW, McCabe BD, Lin P, Boulianne G, O'Kane CJ, Schwarz TL. Members of the synaptobrevin/vesicle-associated membrane protein (VAMP) family in Drosophila are functionally interchangeable in vivo for neurotransmitter release and cell viability. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13867-72. PMID: 12364587.
      View in: PubMed
    51. Stewart BA, Mohtashami M, Rivlin P, Deitcher DL, Trimble WS, Boulianne GL. Dominant-negative NSF2 disrupts the structure and function of Drosophila neuromuscular synapses. J Neurobiol. 2002 Jun 15; 51(4):261-71. PMID: 12150502.
      View in: PubMed
    52. Xu H, Boulianne GL, Trimble WS. Membrane trafficking in cytokinesis. Semin Cell Dev Biol. 2002 Apr; 13(2):77-82. PMID: 12127139.
      View in: PubMed
    53. Zhang SX, Guo Y, Boulianne GL. Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins. Gene. 2001 Dec 12; 280(1-2):135-44. PMID: 11738826.
      View in: PubMed
    54. Rao SS, Stewart BA, Rivlin PK, Vilinsky I, Watson BO, Lang C, Boulianne G, Salpeter MM, Deitcher DL. Two distinct effects on neurotransmission in a temperature-sensitive SNAP-25 mutant. EMBO J. 2001 Dec 03; 20(23):6761-71. PMID: 11726512.
      View in: PubMed
    55. Leventis PA, Chow BM, Stewart BA, Iyengar B, Campos AR, Boulianne GL. Drosophila Amphiphysin is a post-synaptic protein required for normal locomotion but not endocytosis. Traffic. 2001 Nov; 2(11):839-50. PMID: 11733051.
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    56. Yeh E, Dermer M, Commisso C, Zhou L, McGlade CJ, Boulianne GL. Neuralized functions as an E3 ubiquitin ligase during Drosophila development. Curr Biol. 2001 Oct 30; 11(21):1675-9. PMID: 11696324.
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    57. Boulianne GL. Neuronal regulation of lifespan: clues from flies and worms. Mech Ageing Dev. 2001 Jul 15; 122(9):883-94. PMID: 11348656.
      View in: PubMed
    58. Stewart BA, Mohtashami M, Zhou L, Trimble WS, Boulianne GL. SNARE-dependent signaling at the Drosophila wing margin. Dev Biol. 2001 Jun 01; 234(1):13-23. PMID: 11356016.
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    59. Mohtashami M, Stewart BA, Boulianne GL, Trimble WS. Analysis of the mutant Drosophila N-ethylmaleimide sensitive fusion-1 protein in comatose reveals molecular correlates of the behavioural paralysis. J Neurochem. 2001 Jun; 77(5):1407-17. PMID: 11389191.
      View in: PubMed
    60. Stewart BA, Mohtashami M, Trimble WS, Boulianne GL. SNARE proteins contribute to calcium cooperativity of synaptic transmission. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13955-60. PMID: 11095753.
      View in: PubMed
    61. Guo Y, Zhang SX, Sokol N, Cooley L, Boulianne GL. Physical and genetic interaction of filamin with presenilin in Drosophila. J Cell Sci. 2000 Oct; 113 Pt 19:3499-508. PMID: 10984440.
      View in: PubMed
    62. Yeh E, Zhou L, Rudzik N, Boulianne GL. Neuralized functions cell autonomously to regulate Drosophila sense organ development. EMBO J. 2000 Sep 01; 19(17):4827-37. PMID: 10970873.
      View in: PubMed
    63. Guo Y, Livne-Bar I, Zhou L, Boulianne GL. Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling. J Neurosci. 1999 Oct 01; 19(19):8435-42. PMID: 10493744.
      View in: PubMed
    64. Cheung US, Shayan AJ, Boulianne GL, Atwood HL. Drosophila larval neuromuscular junction's responses to reduction of cAMP in the nervous system. J Neurobiol. 1999 Jul; 40(1):1-13. PMID: 10398067.
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    65. Elia AJ, Parkes TL, Kirby K, St George-Hyslop P, Boulianne GL, Phillips JP, Hilliker AJ. Expression of human FALS SOD in motorneurons of Drosophila. Free Radic Biol Med. 1999 May; 26(9-10):1332-8. PMID: 10381207.
      View in: PubMed
    66. Parkes TL, Elia AJ, Dickinson D, Hilliker AJ, Phillips JP, Boulianne GL. Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nat Genet. 1998 Jun; 19(2):171-4. PMID: 9620775.
      View in: PubMed
    67. Cohen B, Bashirullah A, Dagnino L, Campbell C, Fisher WW, Leow CC, Whiting E, Ryan D, Zinyk D, Boulianne G, Hui CC, Gallie B, Phillips RA, Lipshitz HD, Egan SE. Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila. Nat Genet. 1997 Jul; 16(3):283-8. PMID: 9207795.
      View in: PubMed
    68. Honer WG, Falkai P, Young C, Wang T, Xie J, Bonner J, Hu L, Boulianne GL, Luo Z, Trimble WS. Cingulate cortex synaptic terminal proteins and neural cell adhesion molecule in schizophrenia. Neuroscience. 1997 May; 78(1):99-110. PMID: 9135092.
      View in: PubMed
    69. Duttaroy A, Parkes T, Emtage P, Kirby K, Boulianne GL, Wang X, Hilliker AJ, Phillips JP. The manganese superoxide dismutase gene of Drosophila: structure, expression, and evidence for regulation by MAP kinase. DNA Cell Biol. 1997 Apr; 16(4):391-9. PMID: 9150426.
      View in: PubMed
    70. Boulianne GL, Livne-Bar I, Humphreys JM, Liang Y, Lin C, Rogaev E, St George-Hyslop P. Cloning and characterization of the Drosophila presenilin homologue. Neuroreport. 1997 Mar 03; 8(4):1025-9. PMID: 9141085.
      View in: PubMed
    71. Gustafson K, Boulianne GL. Distinct expression patterns detected within individual tissues by the GAL4 enhancer trap technique. Genome. 1996 Feb; 39(1):174-82. PMID: 8851804.
      View in: PubMed
    72. Phillips JP, Tainer JA, Getzoff ED, Boulianne GL, Kirby K, Hilliker AJ. Subunit-destabilizing mutations in Drosophila copper/zinc superoxide dismutase: neuropathology and a model of dimer dysequilibrium. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8574-8. PMID: 7567977.
      View in: PubMed
    73. Yeh E, Gustafson K, Boulianne GL. Green fluorescent protein as a vital marker and reporter of gene expression in Drosophila. Proc Natl Acad Sci U S A. 1995 Jul 18; 92(15):7036-40. PMID: 7624365.
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    74. Boulianne GL, Trimble WS. Identification of a second homolog of N-ethylmaleimide-sensitive fusion protein that is expressed in the nervous system and secretory tissues of Drosophila. Proc Natl Acad Sci U S A. 1995 Jul 18; 92(15):7095-9. PMID: 7624376.
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    75. Zhou L, Boulianne GL. Comparison of the neuralized genes of Drosophila virilis and D. melanogaster. Genome. 1994 Oct; 37(5):840-7. PMID: 8001814.
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    76. Boulianne GL, de la Concha A, Campos-Ortega JA, Jan LY, Jan YN. The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons. EMBO J. 1993 Jun; 12(6):2586. PMID: 8508781.
      View in: PubMed
    77. Boulianne GL, de la Concha A, Campos-Ortega JA, Jan LY, Jan YN. The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons. EMBO J. 1991 Oct; 10(10):2975-83. PMID: 1717258.
      View in: PubMed
    78. Trimble WS, Boulianne GL, Hozumi N. Morphological transformation and tumorigenicity in C3H/10T1/2 cells transformed with an inducible c-Ha-ras oncogene. Biosci Rep. 1987 Jul; 7(7):579-85. PMID: 3318947.
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    79. Boulianne GL, Isenman DE, Hozumi N, Shulman MJ. Biological properties of chimeric antibodies. Interaction with complement. Mol Biol Med. 1987 Feb; 4(1):37-49. PMID: 3613975.
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    80. Trimble WS, Baker MD, Boulianne GL, Murialdo H, Hozumi N, Shulman MJ. Analysis of hybridoma mutants defective in synthesis of immunoglobulin M. Somat Cell Mol Genet. 1986 Sep; 12(5):467-77. PMID: 3020712.
      View in: PubMed
    81. Boulianne GL, Hozumi N, Shulman MJ. Production of functional chimaeric mouse/human antibody. Nature. 1984 Dec 13-19; 312(5995):643-6. PMID: 6095115.
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