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James Ellis

TitleSenior Scientist & Professor-U of T)
InstitutionThe Hospital for Sick Children
DepartmentDevelopmental & Stem Cell Biology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Biography 
    Collapse education and training
    University of Toronto, Ontario, CanadaPhD1990Department of Molecular Genetics
    McGill University, Quebec, CanadaBSc Honours 1984Department of Microbiology and Immunology

    Collapse Overview 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Deneault E, White SH, Rodrigues DC, Ross PJ, Faheem M, Zaslavsky K, Wang Z, Alexandrova R, Pellecchia G, Wei W, Piekna A, Kaur G, Howe JL, Kwan V, Thiruvahindrapuram B, Walker S, Lionel AC, Pasceri P, Merico D, Yuen RKC, Singh KK, Ellis J, Scherer SW. Complete Disruption of Autism-Susceptibility Genes by Gene Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons. Stem Cell Reports. 2018 Nov 13; 11(5):1211-1225. PMID: 30392976.
      View in: PubMed
    2. Reuter MS, Walker S, Thiruvahindrapuram B, Whitney J, Cohn I, Sondheimer N, Yuen RKC, Trost B, Paton TA, Pereira SL, Herbrick JA, Wintle RF, Merico D, Howe J, MacDonald JR, Lu C, Nalpathamkalam T, Sung WWL, Wang Z, Patel RV, Pellecchia G, Wei J, Strug LJ, Bell S, Kellam B, Mahtani MM, Bassett AS, Bombard Y, Weksberg R, Shuman C, Cohn RD, Stavropoulos DJ, Bowdin S, Hildebrandt MR, Wei W, Romm A, Pasceri P, Ellis J, Ray P, Meyn MS, Monfared N, Hosseini SM, Joseph-George AM, Keeley FW, Cook RA, Fiume M, Lee HC, Marshall CR, Davies J, Hazell A, Buchanan JA, Szego MJ, Scherer SW. The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants. CMAJ. 2018 Feb 05; 190(5):E126-E136. PMID: 29431110.
      View in: PubMed
    3. Shafa M, Ionescu LI, Vadivel A, Collins JJP, Xu L, Zhong S, Kang M, de Caen G, Daneshmand M, Shi J, Fu KZ, Qi A, Wang Y, Ellis J, Stanford WL, Thébaud B. Human induced pluripotent stem cell-derived lung progenitor and alveolar epithelial cells attenuate hyperoxia-induced lung injury. Cytotherapy. 2018 Jan; 20(1):108-125. PMID: 29056548.
      View in: PubMed
    4. Djuric U, Rodrigues DC, Batruch I, Ellis J, Shannon P, Diamandis P. Spatiotemporal Proteomic Profiling of Human Cerebral Development. Mol Cell Proteomics. 2017 09; 16(9):1548-1562. PMID: 28687556.
      View in: PubMed
    5. Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Doré C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ, Galas DJ, Stanford WL. Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape. Aging Cell. 2017 08; 16(4):870-887. PMID: 28597562.
      View in: PubMed
    6. Rodrigues DC, Kim DS, Yang G, Zaslavsky K, Ha KC, Mok RS, Ross PJ, Zhao M, Piekna A, Wei W, Blencowe BJ, Morris Q, Ellis J. MECP2 Is Post-transcriptionally Regulated during Human Neurodevelopment by Combinatorial Action of RNA-Binding Proteins and miRNAs. Cell Rep. 2016 10 11; 17(3):720-734. PMID: 27732849.
      View in: PubMed
    7. Novo CL, Tang C, Ahmed K, Djuric U, Fussner E, Mullin NP, Morgan NP, Hayre J, Sienerth AR, Elderkin S, Nishinakamura R, Chambers I, Ellis J, Bazett-Jones DP, Rugg-Gunn PJ. The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells. Genes Dev. 2016 05 01; 30(9):1101-15. PMID: 27125671; PMCID: PMC4863740.
    8. Zhang WB, Ross PJ, Tu Y, Wang Y, Beggs S, Sengar AS, Ellis J, Salter MW. Fyn Kinase regulates GluN2B subunit-dominant NMDA receptors in human induced pluripotent stem cell-derived neurons. Sci Rep. 2016 Apr 04; 6:23837. PMID: 27040756; PMCID: PMC4819183.
    9. Khattak S, Brimble E, Zhang W, Zaslavsky K, Strong E, Ross PJ, Hendry J, Mital S, Salter MW, Osborne LR, Ellis J. Human induced pluripotent stem cell derived neurons as a model for Williams-Beuren syndrome. Mol Brain. 2015 Nov 24; 8(1):77. PMID: 26603386; PMCID: PMC4657290.
    10. Edwards AM, Arrowsmith CH, Bountra C, Bunnage ME, Feldmann M, Knight JC, Patel DD, Prinos P, Taylor MD, Sundström M. Preclinical target validation using patient-derived cells. Nat Rev Drug Discov. 2015 Mar; 14(3):149-50. PMID: 25722227.
      View in: PubMed
    11. Djuric U, Cheung AYL, Zhang W, Mok RS, Lai W, Piekna A, Hendry JA, Ross PJ, Pasceri P, Kim DS, Salter MW, Ellis J. MECP2e1 isoform mutation affects the form and function of neurons derived from Rett syndrome patient iPS cells. Neurobiol Dis. 2015 Apr; 76:37-45. PMID: 25644311.
      View in: PubMed
    12. Kim DS, Ross PJ, Zaslavsky K, Ellis J. Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD. Front Cell Neurosci. 2014; 8:109. PMID: 24782713; PMCID: PMC3990101.
    13. Orlic-Milacic M, Kaufman L, Mikhailov A, Cheung AY, Mahmood H, Ellis J, Gianakopoulos PJ, Minassian BA, Vincent JB. Over-expression of either MECP2_e1 or MECP2_e2 in neuronally differentiated cells results in different patterns of gene expression. PLoS One. 2014; 9(4):e91742. PMID: 24699272; PMCID: PMC3974668.
    14. Rival-Gervier S, Lo MY, Khattak S, Pasceri P, Lorincz MC, Ellis J. Kinetics and epigenetics of retroviral silencing in mouse embryonic stem cells defined by deletion of the D4Z4 element. Mol Ther. 2013 Aug; 21(8):1536-50. PMID: 23752310; PMCID: PMC3734652.
    15. Han H, Irimia M, Ross PJ, Sung HK, Alipanahi B, David L, Golipour A, Gabut M, Michael IP, Nachman EN, Wang E, Trcka D, Thompson T, O'Hanlon D, Slobodeniuc V, Barbosa-Morais NL, Burge CB, Moffat J, Frey BJ, Nagy A, Ellis J, Wrana JL, Blencowe BJ. MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature. 2013 Jun 13; 498(7453):241-5. PMID: 23739326; PMCID: PMC3933998.
    16. Yamashita A, Liu S, Woltjen K, Thomas B, Meng G, Hotta A, Takahashi K, Ellis J, Yamanaka S, Rancourt DE. Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells. Sci Rep. 2013; 3:1978. PMID: 23760219; PMCID: PMC3680803.
    17. Kinnear C, Chang WY, Khattak S, Hinek A, Thompson T, de Carvalho Rodrigues D, Kennedy K, Mahmut N, Pasceri P, Stanford WL, Ellis J, Mital S. Modeling and rescue of the vascular phenotype of Williams-Beuren syndrome in patient induced pluripotent stem cells. Stem Cells Transl Med. 2013 Jan; 2(1):2-15. PMID: 23283491; PMCID: PMC3659746.
    18. Fussner E, Strauss M, Djuric U, Li R, Ahmed K, Hart M, Ellis J, Bazett-Jones DP. Open and closed domains in the mouse genome are configured as 10-nm chromatin fibres. EMBO Rep. 2012 Nov 06; 13(11):992-6. PMID: 22986547; PMCID: PMC3492707.
    19. Wong AP, Bear CE, Chin S, Pasceri P, Thompson TO, Huan LJ, Ratjen F, Ellis J, Rossant J. Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein. Nat Biotechnol. 2012 Sep; 30(9):876-82. PMID: 22922672; PMCID: PMC3994104.
    20. Lo MY, Rival-Gervier S, Pasceri P, Ellis J. Rapid transcriptional pulsing dynamics of high expressing retroviral transgenes in embryonic stem cells. PLoS One. 2012; 7(5):e37130. PMID: 22606340; PMCID: PMC3351450.
    21. Cheung AY, Horvath LM, Carrel L, Ellis J. X-chromosome inactivation in rett syndrome human induced pluripotent stem cells. Front Psychiatry. 2012; 3:24. PMID: 22470355; PMCID: PMC3311266.
    22. Farra N, Manickaraj AK, Ellis J, Mital S. Personalized Medicine in the Genomics Era: highlights from an international symposium on childhood heart disease. Future Cardiol. 2012 Mar; 8(2):157-60. PMID: 22413975.
      View in: PubMed
    23. Amenduni M, De Filippis R, Cheung AY, Disciglio V, Epistolato MC, Ariani F, Mari F, Mencarelli MA, Hayek Y, Renieri A, Ellis J, Meloni I. iPS cells to model CDKL5-related disorders. Eur J Hum Genet. 2011 Dec; 19(12):1246-55. PMID: 21750574; PMCID: PMC3218106.
    24. Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, Wigle TJ, Dimaggio PA, Wasney GA, Siarheyeva A, Dong A, Tempel W, Wang SC, Chen X, Chau I, Mangano TJ, Huang XP, Simpson CD, Pattenden SG, Norris JL, Kireev DB, Tripathy A, Edwards A, Roth BL, Janzen WP, Garcia BA, Petronis A, Ellis J, Brown PJ, Frye SV, Arrowsmith CH, Jin J. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol. 2011 Jul 10; 7(8):566-74. PMID: 21743462; PMCID: PMC3184254.
    25. Ellis JR, Heinrich B, Mautner VF, Kluwe L. Effects of splicing mutations on NF2-transcripts: transcript analysis and information theoretic predictions. Genes Chromosomes Cancer. 2011 Aug; 50(8):571-84. PMID: 21563229.
      View in: PubMed
    26. Ellis J, Bhatia M. iPSC technology: platform for drug discovery. Point. Clin Pharmacol Ther. 2011 May; 89(5):639-41. PMID: 21512521.
      View in: PubMed
    27. Fussner E, Djuric U, Strauss M, Hotta A, Perez-Iratxeta C, Lanner F, Dilworth FJ, Ellis J, Bazett-Jones DP. Constitutive heterochromatin reorganization during somatic cell reprogramming. EMBO J. 2011 May 04; 30(9):1778-89. PMID: 21468033; PMCID: PMC3102001.
    28. Kinoshita T, Nagamatsu G, Kosaka T, Takubo K, Hotta A, Ellis J, Suda T. Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells. Biochem Biophys Res Commun. 2011 Apr 08; 407(2):321-6. PMID: 21385566.
      View in: PubMed
    29. Cheung AY, Horvath LM, Grafodatskaya D, Pasceri P, Weksberg R, Hotta A, Carrel L, Ellis J. Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation. Hum Mol Genet. 2011 Jun 01; 20(11):2103-15. PMID: 21372149; PMCID: PMC3090191.
    30. Kattman SJ, Witty AD, Gagliardi M, Dubois NC, Niapour M, Hotta A, Ellis J, Keller G. Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell. 2011 Feb 04; 8(2):228-40. PMID: 21295278.
      View in: PubMed
    31. Ross PJ, Ellis J. Modeling complex neuropsychiatric disease with induced pluripotent stem cells. F1000 Biol Rep. 2010 Dec 08; 2:84. PMID: 21283649; PMCID: PMC3026614.
    32. Ellis J, Baum C, Benvenisty N, Mostoslavsky G, Okano H, Stanford WL, Porteus M, Sadelain M. Benefits of utilizing gene-modified iPSCs for clinical applications. Cell Stem Cell. 2010 Oct 08; 7(4):429-30. PMID: 20887948.
      View in: PubMed
    33. Yantha J, Tsui H, Winer S, Song A, Wu P, Paltser G, Ellis J, Dosch HM. Unexpected acceleration of type 1 diabetes by transgenic expression of B7-H1 in NOD mouse peri-islet glia. Diabetes. 2010 Oct; 59(10):2588-96. PMID: 20522597; PMCID: PMC3279538.
    34. Djuric U, Ellis J. Epigenetics of induced pluripotency, the seven-headed dragon. Stem Cell Res Ther. 2010 Mar 15; 1(1):3. PMID: 20504284; PMCID: PMC2873696.
    35. Izpisúa Belmonte JC, Ellis J, Hochedlinger K, Yamanaka S. Induced pluripotent stem cells and reprogramming: seeing the science through the hype. Nat Rev Genet. 2009 12; 10(12):878-83. PMID: 19859062.
      View in: PubMed
    36. Sing A, Pannell D, Karaiskakis A, Sturgeon K, Djabali M, Ellis J, Lipshitz HD, Cordes SP. A vertebrate Polycomb response element governs segmentation of the posterior hindbrain. Cell. 2009 Sep 04; 138(5):885-97. PMID: 19737517.
      View in: PubMed
    37. Rastegar M, Hotta A, Pasceri P, Makarem M, Cheung AY, Elliott S, Park KJ, Adachi M, Jones FS, Clarke ID, Dirks P, Ellis J. MECP2 isoform-specific vectors with regulated expression for Rett syndrome gene therapy. PLoS One. 2009 Aug 27; 4(8):e6810. PMID: 19710912; PMCID: PMC2728539.
    38. Hotta A, Cheung AY, Farra N, Vijayaragavan K, Séguin CA, Draper JS, Pasceri P, Maksakova IA, Mager DL, Rossant J, Bhatia M, Ellis J. Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency. Nat Methods. 2009 May; 6(5):370-6. PMID: 19404254.
      View in: PubMed
    39. Ellis J, Bruneau BG, Keller G, Lemischka IR, Nagy A, Rossant J, Srivastava D, Zandstra PW, Stanford WL. Alternative induced pluripotent stem cell characterization criteria for in vitro applications. Cell Stem Cell. 2009 Mar 06; 4(3):198-9; author reply 202. PMID: 19265656.
      View in: PubMed
    40. Hotta A, Cheung AY, Farra N, Garcha K, Chang WY, Pasceri P, Stanford WL, Ellis J. EOS lentiviral vector selection system for human induced pluripotent stem cells. Nat Protoc. 2009; 4(12):1828-44. PMID: 20010937.
      View in: PubMed
    41. Hotta A, Ellis J. Retroviral vector silencing during iPS cell induction: an epigenetic beacon that signals distinct pluripotent states. J Cell Biochem. 2008 Nov 01; 105(4):940-8. PMID: 18773452.
      View in: PubMed
    42. Buzina A, Lo MY, Moffett A, Hotta A, Fussner E, Bharadwaj RR, Pasceri P, Garcia-Martinez JV, Bazett-Jones DP, Ellis J. Beta-globin LCR and intron elements cooperate and direct spatial reorganization for gene therapy. PLoS Genet. 2008 Apr 11; 4(4):e1000051. PMID: 18404216; PMCID: PMC2271131.
    43. Tsui H, Chan Y, Tang L, Winer S, Cheung RK, Paltser G, Selvanantham T, Elford AR, Ellis JR, Becker DJ, Ohashi PS, Dosch HM. Targeting of pancreatic glia in type 1 diabetes. Diabetes. 2008 Apr; 57(4):918-28. PMID: 18198358.
      View in: PubMed
    44. Ellis J, Hotta A, Rastegar M. Retrovirus silencing by an epigenetic TRIM. Cell. 2007 Oct 05; 131(1):13-4. PMID: 17923079.
      View in: PubMed
    45. Ramunas J, Montgomery HJ, Kelly L, Sukonnik T, Ellis J, Jervis EJ. Real-time fluorescence tracking of dynamic transgene variegation in stem cells. Mol Ther. 2007 Apr; 15(4):810-7. PMID: 17285140.
      View in: PubMed
    46. Ellis J. Silencing and variegation of gammaretrovirus and lentivirus vectors. Hum Gene Ther. 2005 Nov; 16(11):1241-6. PMID: 16259557.
      View in: PubMed
    47. Chen J, Reifsnyder PC, Scheuplein F, Schott WH, Mileikovsky M, Soodeen-Karamath S, Nagy A, Dosch MH, Ellis J, Koch-Nolte F, Leiter EH. "Agouti NOD": identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells. Mamm Genome. 2005 Oct; 16(10):775-83. PMID: 16261419.
      View in: PubMed
    48. Lam PP, Leung YM, Sheu L, Ellis J, Tsushima RG, Osborne LR, Gaisano HY. Transgenic mouse overexpressing syntaxin-1A as a diabetes model. Diabetes. 2005 Sep; 54(9):2744-54. PMID: 16123365.
      View in: PubMed
    49. Buzina A, Aladjem MI, Kolman JL, Wahl GM, Ellis J. Initiation of DNA replication at the human beta-globin 3' enhancer. Nucleic Acids Res. 2005; 33(14):4412-24. PMID: 16085752; PMCID: PMC1183104.
    50. Ellis J, Yao S. Retrovirus silencing and vector design: relevance to normal and cancer stem cells? Curr Gene Ther. 2005 Aug; 5(4):367-73. PMID: 16101511.
      View in: PubMed
    51. Dalle B, Rubin JE, Alkan O, Sukonnik T, Pasceri P, Yao S, Pawliuk R, Leboulch P, Ellis J. eGFP reporter genes silence LCRbeta-globin transgene expression via CpG dinucleotides. Mol Ther. 2005 Apr; 11(4):591-9. PMID: 15771961.
      View in: PubMed
    52. Goldin E, Stahl S, Cooney AM, Kaneski CR, Gupta S, Brady RO, Ellis JR, Schiffmann R. Transfer of a mitochondrial DNA fragment to MCOLN1 causes an inherited case of mucolipidosis IV. Hum Mutat. 2004 Dec; 24(6):460-5. PMID: 15523648.
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    53. Yao S, Sukonnik T, Kean T, Bharadwaj RR, Pasceri P, Ellis J. Retrovirus silencing, variegation, extinction, and memory are controlled by a dynamic interplay of multiple epigenetic modifications. Mol Ther. 2004 Jul; 10(1):27-36. PMID: 15233939.
      View in: PubMed
    54. Yao S, Osborne CS, Bharadwaj RR, Pasceri P, Sukonnik T, Pannell D, Recillas-Targa F, West AG, Ellis J. Retrovirus silencer blocking by the cHS4 insulator is CTCF independent. Nucleic Acids Res. 2003 Sep 15; 31(18):5317-23. PMID: 12954767; PMCID: PMC203325.
    55. Hellerud C, Adamowicz M, Jurkiewicz D, Taybert J, Kubalska J, Ciara E, Popowska E, Ellis JR, Lindstedt S, Pronicka E. Clinical heterogeneity and molecular findings in five Polish patients with glycerol kinase deficiency: investigation of two splice site mutations with computerized splice junction analysis and Xp21 gene-specific mRNA analysis. Mol Genet Metab. 2003 Jul; 79(3):149-59. PMID: 12855219.
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    56. Ostermeier GC, Liu Z, Martins RP, Bharadwaj RR, Ellis J, Draghici S, Krawetz SA. Nuclear matrix association of the human beta-globin locus utilizing a novel approach to quantitative real-time PCR. Nucleic Acids Res. 2003 Jun 15; 31(12):3257-66. PMID: 12799453; PMCID: PMC162328.
    57. Song A, Winer S, Tsui H, Sampson A, Pasceri P, Ellis J, Elliott JF, Dosch HM. Deviation of islet autoreactivity to cryptic epitopes protects NOD mice from diabetes. Eur J Immunol. 2003 Feb; 33(2):546-55. PMID: 12645954.
      View in: PubMed
    58. Bharadwaj RR, Trainor CD, Pasceri P, Ellis J. LCR-regulated transgene expression levels depend on the Oct-1 site in the AT-rich region of beta -globin intron-2. Blood. 2003 Feb 15; 101(4):1603-10. PMID: 12393478.
      View in: PubMed
    59. Pawliuk R, Westerman KA, Fabry ME, Payen E, Tighe R, Bouhassira EE, Acharya SA, Ellis J, London IM, Eaves CJ, Humphries RK, Beuzard Y, Nagel RL, Leboulch P. Correction of sickle cell disease in transgenic mouse models by gene therapy. Science. 2001 Dec 14; 294(5550):2368-71. PMID: 11743206.
      View in: PubMed
    60. Moreau-Gaudry F, Xia P, Jiang G, Perelman NP, Bauer G, Ellis J, Surinya KH, Mavilio F, Shen CK, Malik P. High-level erythroid-specific gene expression in primary human and murine hematopoietic cells with self-inactivating lentiviral vectors. Blood. 2001 Nov 01; 98(9):2664-72. PMID: 11675336.
      View in: PubMed
    61. Pannell D, Ellis J. Silencing of gene expression: implications for design of retrovirus vectors. Rev Med Virol. 2001 Jul-Aug; 11(4):205-17. PMID: 11479927.
      View in: PubMed
    62. Jiang Z, Guo Z, Saad FA, Ellis J, Zacksenhaus E. Retinoblastoma gene promoter directs transgene expression exclusively to the nervous system. J Biol Chem. 2001 Jan 05; 276(1):593-600. PMID: 11016928.
      View in: PubMed
    63. Ellis J, Pannell D. The beta-globin locus control region versus gene therapy vectors: a struggle for expression. Clin Genet. 2001 Jan; 59(1):17-24. PMID: 11168020.
      View in: PubMed
    64. Pannell D, Osborne CS, Yao S, Sukonnik T, Pasceri P, Karaiskakis A, Okano M, Li E, Lipshitz HD, Ellis J. Retrovirus vector silencing is de novo methylase independent and marked by a repressive histone code. EMBO J. 2000 Nov 01; 19(21):5884-94. PMID: 11060039; PMCID: PMC305782.
    65. Rubin JE, Pasceri P, Wu X, Leboulch P, Ellis J. Locus control region activity by 5'HS3 requires a functional interaction with beta-globin gene regulatory elements: expression of novel beta/gamma-globin hybrid transgenes. Blood. 2000 May 15; 95(10):3242-9. PMID: 10807795.
      View in: PubMed
    66. Osborne CS, Pasceri P, Singal R, Sukonnik T, Ginder GD, Ellis J. Amelioration of retroviral vector silencing in locus control region beta-globin-transgenic mice and transduced F9 embryonic cells. J Virol. 1999 Jul; 73(7):5490-6. PMID: 10364297; PMCID: PMC112606.
    67. Pasceri P, Pannell D, Wu X, Ellis J. Full activity from human beta-globin locus control region transgenes requires 5'HS1, distal beta-globin promoter, and 3' beta-globin sequences. Blood. 1998 Jul 15; 92(2):653-63. PMID: 9657768.
      View in: PubMed
    68. Murdoch B, Pereira DS, Wu X, Dick JE, Ellis J. A rapid screening procedure for the identification of high-titer retrovirus packaging clones. Gene Ther. 1997 Jul; 4(7):744-9. PMID: 9282176.
      View in: PubMed
    69. Ellis J, Pasceri P, Tan-Un KC, Wu X, Harper A, Fraser P, Grosveld F. Evaluation of beta-globin gene therapy constructs in single copy transgenic mice. Nucleic Acids Res. 1997 Mar 15; 25(6):1296-302. PMID: 9092642; PMCID: PMC146564.
    70. Ellis J, Tan-Un KC, Harper A, Michalovich D, Yannoutsos N, Philipsen S, Grosveld F. A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region. EMBO J. 1996 Feb 01; 15(3):562-8. PMID: 8599939; PMCID: PMC449974.
    71. Ellis J, Talbot D, Dillon N, Grosveld F. Synthetic human beta-globin 5'HS2 constructs function as locus control regions only in multicopy transgene concatamers. EMBO J. 1993 Jan; 12(1):127-34. PMID: 8428573; PMCID: PMC413182.
    72. Steeg CM, Ellis J, Bernstein A. Introduction of specific point mutations into RNA polymerase II by gene targeting in mouse embryonic stem cells: evidence for a DNA mismatch repair mechanism. Proc Natl Acad Sci U S A. 1990 Jun; 87(12):4680-4. PMID: 1972278; PMCID: PMC54180.
    73. Ellis J, Bernstein A. Retrovirus vectors containing an internal attachment site: evidence that circles are not intermediates to murine retrovirus integration. J Virol. 1989 Jun; 63(6):2844-6. PMID: 2724414; PMCID: PMC250795.
    74. Ellis J, Bernstein A. Gene targeting with retroviral vectors: recombination by gene conversion into regions of nonhomology. Mol Cell Biol. 1989 Apr; 9(4):1621-7. PMID: 2725520; PMCID: PMC362579.
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