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Janet Rossant

TitleSenior Scientist & Chief of Research Emeritus
InstitutionThe Hospital for Sick Children
DepartmentDevelopmental & Stem Cell Biology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rossant J. Genetic Control of Early Cell Lineages in the Mammalian Embryo. Annu Rev Genet. 2018 Nov 23; 52:185-201. PMID: 30183407.
      View in: PubMed
    2. Rossant J. Gene editing in human development: ethical concerns and practical applications. Development. 2018 07 25; 145(16). PMID: 30045910.
      View in: PubMed
    3. Gu B, Posfai E, Rossant J. Efficient generation of targeted large insertions by microinjection into two-cell-stage mouse embryos. Nat Biotechnol. 2018 08; 36(7):632-637. PMID: 29889212.
      View in: PubMed
    4. Rossant J, Tam PPL. Exploring early human embryo development. Science. 2018 06 08; 360(6393):1075-1076. PMID: 29880675.
      View in: PubMed
    5. Eckford PDW, McCormack J, Munsie L, He G, Stanojevic S, Pereira SL, Ho K, Avolio J, Bartlett C, Yang JY, Wong AP, Wellhauser L, Huan LJ, Jiang JX, Ouyang H, Du K, Klingel M, Kyriakopoulou L, Gonska T, Moraes TJ, Strug LJ, Rossant J, Ratjen F, Bear CE. The CF Canada-Sick Kids Program in individual CF therapy: A resource for the advancement of personalized medicine in CF. J Cyst Fibros. 2018 Apr 20. PMID: 29685812.
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    6. Yachie-Kinoshita A, Onishi K, Ostblom J, Langley MA, Posfai E, Rossant J, Zandstra PW. Modeling signaling-dependent pluripotency with Boolean logic to predict cell fate transitions. Mol Syst Biol. 2018 01 29; 14(1):e7952. PMID: 29378814.
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    7. Sun X, Hota SK, Zhou YQ, Novak S, Miguel-Perez D, Christodoulou D, Seidman CE, Seidman JG, Gregorio CC, Henkelman RM, Rossant J, Bruneau BG. Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function. Biol Open. 2018 Jan 05; 7(1). PMID: 29183906.
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    8. Huang D, Guo G, Yuan P, Ralston A, Sun L, Huss M, Mistri T, Pinello L, Ng HH, Yuan G, Ji J, Rossant J, Robson P, Han X. The role of Cdx2 as a lineage specific transcriptional repressor for pluripotent network during the first developmental cell lineage segregation. Sci Rep. 2017 Dec 07; 7(1):17156. PMID: 29214996.
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    9. Farah O, Biechele S, Rossant J, Dufort D. Porcupine-dependent Wnt activity within the uterine epithelium is essential for fertility. Biol Reprod. 2017 Nov 01; 97(5):688-697. PMID: 29036275.
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    10. Farah O, Biechele S, Rossant J, Dufort D. Regulation of porcupine-dependent Wnt signaling is essential for uterine development and function. Reproduction. 2018 01; 155(1):93-102. PMID: 29066530.
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    11. Pei D, Beier DW, Levy-Lahad E, Marchant G, Rossant J, Izpisua Belmonte JC, Lovell-Badge R, Jaenisch R, Charo A, Baltimore D. Human Embryo Editing: Opportunities and Importance of Transnational Cooperation. Cell Stem Cell. 2017 10 05; 21(4):423-426. PMID: 28985523.
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    12. Gu B, Lambert JP, Cockburn K, Gingras AC, Rossant J. AIRE is a critical spindle-associated protein in embryonic stem cells. Elife. 2017 07 25; 6. PMID: 28742026.
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    13. Ahmadi S, Bozoky Z, Di Paola M, Xia S, Li C, Wong AP, Wellhauser L, Molinski SV, Ip W, Ouyang H, Avolio J, Forman-Kay JD, Ratjen F, Hirota JA, Rommens J, Rossant J, Gonska T, Moraes TJ, Bear CE. Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia. NPJ Genom Med. 2017 Apr 14; 2:12. PMID: 28649446.
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    14. Posfai E, Petropoulos S, de Barros FRO, Schell JP, Jurisica I, Sandberg R, Lanner F, Rossant J. Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo. Elife. 2017 02 22; 6. PMID: 28226240.
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    15. Rossant J, Tam PPL. New Insights into Early Human Development: Lessons for Stem Cell Derivation and Differentiation. Cell Stem Cell. 2017 01 05; 20(1):18-28. PMID: 28061351.
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    16. Farah O, Biechele S, Rossant J, Dufort D. Porcupine-dependent Wnt signaling controls stromal proliferation and endometrial gland maintenance through the action of distinct WNTs. Dev Biol. 2017 02 01; 422(1):58-69. PMID: 27965056.
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    17. Wu J, Greely HT, Jaenisch R, Nakauchi H, Rossant J, Belmonte JC. Stem cells and interspecies chimaeras. Nature. 2016 12 01; 540(7631):51-59. PMID: 27905428.
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    18. Hammoud L, Adams JR, Loch AJ, Marcellus RC, Uehling DE, Aman A, Fladd C, McKee TD, Jo CEB, Al-Awar R, Egan SE, Rossant J. Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay. Stem Cell Reports. 2016 10 11; 7(4):787-801. PMID: 27618721.
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    19. Rayon T, Menchero S, Rollán I, Ors I, Helness A, Crespo M, Nieto A, Azuara V, Rossant J, Manzanares M. Distinct mechanisms regulate Cdx2 expression in the blastocyst and in trophoblast stem cells. Sci Rep. 2016 06 03; 6:27139. PMID: 27256674.
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    20. Otowa Y, Moriwaki K, Sano K, Shirakabe M, Yonemura S, Shibuya M, Rossant J, Suda T, Kakeji Y, Hirashima M. Flt1/VEGFR1 heterozygosity causes transient embryonic edema. Sci Rep. 2016 06 02; 6:27186. PMID: 27251772.
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    21. Rossant J. Human embryology: Implantation barrier overcome. Nature. 2016 05 12; 533(7602):182-3. PMID: 27144361.
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    22. Posfai E, Rossant J. Depending on maternal Yap. Cell Res. 2016 Apr; 26(4):393-4. PMID: 27012469; PMCID: PMC4822131 [Available on 04/01/17].
    23. Abbassi L, Malki S, Cockburn K, Macaulay A, Robert C, Rossant J, Clarke HJ. Multiple Mechanisms Cooperate to Constitutively Exclude the Transcriptional Co-Activator YAP from the Nucleus During Murine Oogenesis. Biol Reprod. 2016 05; 94(5):102. PMID: 26985001.
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    24. Rossant J. Making the Mouse Blastocyst: Past, Present, and Future. Curr Top Dev Biol. 2016; 117:275-88. PMID: 26969983.
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    25. Lee CQ, Gardner L, Turco M, Zhao N, Murray MJ, Coleman N, Rossant J, Hemberger M, Moffett A. What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast. Stem Cell Reports. 2016 Feb 09; 6(2):257-72. PMID: 26862703; PMCID: PMC4750161.
    26. Frankenberg SR, de Barros FR, Rossant J, Renfree MB. The mammalian blastocyst. Wiley Interdiscip Rev Dev Biol. 2016 Mar-Apr; 5(2):210-32. PMID: 26799266.
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    27. De Los Angeles A, Ferrari F, Xi R, Fujiwara Y, Benvenisty N, Deng H, Hochedlinger K, Jaenisch R, Lee S, Leitch HG, Lensch MW, Lujan E, Pei D, Rossant J, Wernig M, Park PJ, Daley GQ. Corrigendum: Hallmarks of pluripotency. Nature. 2016 Mar 17; 531(7594):400. PMID: 26675727.
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    28. Kurmann AA, Serra M, Hawkins F, Rankin SA, Mori M, Astapova I, Ullas S, Lin S, Bilodeau M, Rossant J, Jean JC, Ikonomou L, Deterding RR, Shannon JM, Zorn AM, Hollenberg AN, Kotton DN. Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells. Cell Stem Cell. 2015 Nov 05; 17(5):527-42. PMID: 26593959; PMCID: PMC4666682 [Available on 11/05/16].
    29. De Los Angeles A, Ferrari F, Xi R, Fujiwara Y, Benvenisty N, Deng H, Hochedlinger K, Jaenisch R, Lee S, Leitch HG, Lensch MW, Lujan E, Pei D, Rossant J, Wernig M, Park PJ, Daley GQ. Hallmarks of pluripotency. Nature. 2015 Sep 24; 525(7570):469-78. PMID: 26399828.
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    30. de Angelis MH, Nicholson G, Selloum M, White J, Morgan H, Ramirez-Solis R, Sorg T, Wells S, Fuchs H, Fray M, Adams DJ, Adams NC, Adler T, Aguilar-Pimentel A, Ali-Hadji D, Amann G, André P, Atkins S, Auburtin A, Ayadi A, Becker J, Becker L, Bedu E, Bekeredjian R, Birling MC, Blake A, Bottomley J, Bowl M, Brault V, Busch DH, Bussell JN, Calzada-Wack J, Cater H, Champy MF, Charles P, Chevalier C, Chiani F, Codner GF, Combe R, Cox R, Dalloneau E, Dierich A, Di Fenza A, Doe B, Duchon A, Eickelberg O, Esapa CT, El Fertak L, Feigel T, Emelyanova I, Estabel J, Favor J, Flenniken A, Gambadoro A, Garrett L, Gates H, Gerdin AK, Gkoutos G, Greenaway S, Glasl L, Goetz P, Da Cruz IG, Götz A, Graw J, Guimond A, Hans W, Hicks G, Hölter SM, Höfler H, Hancock JM, Hoehndorf R, Hough T, Houghton R, Hurt A, Ivandic B, Jacobs H, Jacquot S, Jones N, Karp NA, Katus HA, Kitchen S, Klein-Rodewald T, Klingenspor M, Klopstock T, Lalanne V, Leblanc S, Lengger C, le Marchand E, Ludwig T, Lux A, McKerlie C, Maier H, Mandel JL, Marschall S, Mark M, Melvin DG, Meziane H, Micklich K, Mittelhauser C, Monassier L, Moulaert D, Muller S, Naton B, Neff F, Nolan PM, Nutter LM, Ollert M, Pavlovic G, Pellegata NS, Peter E, Petit-Demoulière B, Pickard A, Podrini C, Potter P, Pouilly L, Puk O, Richardson D, Rousseau S, Quintanilla-Fend L, Quwailid MM, Racz I, Rathkolb B, Riet F, Rossant J, Roux M, Rozman J, Ryder E, Salisbury J, Santos L, Schäble KH, Schiller E, Schrewe A, Schulz H, Steinkamp R, Simon M, Stewart M, Stöger C, Stöger T, Sun M, Sunter D, Teboul L, Tilly I, Tocchini-Valentini GP, Tost M, Treise I, Vasseur L, Velot E, Vogt-Weisenhorn D, Wagner C, Walling A, Weber B, Wendling O, Westerberg H, Willershäuser M, Wolf E, Wolter A, Wood J, Wurst W, Yildirim AÖ, Zeh R, Zimmer A, Zimprich A, Holmes C, Steel KP, Herault Y, Gailus-Durner V, Mallon AM, Brown SD. Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics. Nat Genet. 2015 Sep; 47(9):969-978. PMID: 26214591.
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    31. Li L, Song L, Liu C, Chen J, Peng G, Wang R, Liu P, Tang K, Rossant J, Jing N. Ectodermal progenitors derived from epiblast stem cells by inhibition of Nodal signaling. J Mol Cell Biol. 2015 Oct; 7(5):455-65. PMID: 25990320.
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    32. Wong AP, Chin S, Xia S, Garner J, Bear CE, Rossant J. Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells. Nat Protoc. 2015 Mar; 10(3):363-81. PMID: 25654755.
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    33. Shojaie S, Ermini L, Ackerley C, Wang J, Chin S, Yeganeh B, Bilodeau M, Sambi M, Rogers I, Rossant J, Bear CE, Post M. Acellular lung scaffolds direct differentiation of endoderm to functional airway epithelial cells: requirement of matrix-bound HS proteoglycans. Stem Cell Reports. 2015 Mar 10; 4(3):419-30. PMID: 25660407; PMCID: PMC4375883.
    34. Rossant J. Mouse and human blastocyst-derived stem cells: vive les differences. Development. 2015 Jan 01; 142(1):9-12. PMID: 25516964.
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    35. McDonald AC, Rossant J. Gut endoderm takes flight from the wings of mesoderm. Nat Cell Biol. 2014 Dec; 16(12):1128-9. PMID: 25434463.
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    36. McDonald AC, Biechele S, Rossant J, Stanford WL. Sox17-mediated XEN cell conversion identifies dynamic networks controlling cell-fate decisions in embryo-derived stem cells. Cell Rep. 2014 Oct 23; 9(2):780-93. PMID: 25373912.
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    37. Kunath T, Yamanaka Y, Detmar J, MacPhee D, Caniggia I, Rossant J, Jurisicova A. Developmental differences in the expression of FGF receptors between human and mouse embryos. Placenta. 2014 Dec; 35(12):1079-88. PMID: 25443433.
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    38. Bilodeau M, Shojaie S, Ackerley C, Post M, Rossant J. Identification of a proximal progenitor population from murine fetal lungs with clonogenic and multilineage differentiation potential. Stem Cell Reports. 2014 Oct 14; 3(4):634-49. PMID: 25358791; PMCID: PMC4223706.
    39. Rayon T, Menchero S, Nieto A, Xenopoulos P, Crespo M, Cockburn K, Cañon S, Sasaki H, Hadjantonakis AK, de la Pompa JL, Rossant J, Manzanares M. Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst. Dev Cell. 2014 Aug 25; 30(4):410-22. PMID: 25127056; PMCID: PMC4146744.
    40. Rossant J. A trusted voice for stem cell research. Stem Cell Reports. 2014 Jun 03; 2(6):749-50. PMID: 24936462; PMCID: PMC4050348.
    41. Chen F, Guo R, Itoh S, Moreno L, Rosenthal E, Zappitelli T, Zirngibl RA, Flenniken A, Cole W, Grynpas M, Osborne LR, Vogel W, Adamson L, Rossant J, Aubin JE. First mouse model for combined osteogenesis imperfecta and Ehlers-Danlos syndrome. J Bone Miner Res. 2014 Jun; 29(6):1412-23. PMID: 24443344.
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    42. Kabiri Z, Greicius G, Madan B, Biechele S, Zhong Z, Zaribafzadeh H, Aliyev J, Wu Y, Bunte R, Williams BO, Rossant J, Virshup DM. Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts. Development. 2014 Jun; 141(11):2206-15. PMID: 24821987.
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    43. Rossant J. Genes for regeneration. Elife. 2014 Apr 15; 3:e02517. PMID: 24737866; PMCID: PMC3985189.
    44. Saccone V, Consalvi S, Giordani L, Mozzetta C, Barozzi I, Sandoná M, Ryan T, Rojas-Muñoz A, Madaro L, Fasanaro P, Borsellino G, De Bardi M, Frigè G, Termanini A, Sun X, Rossant J, Bruneau BG, Mercola M, Minucci S, Puri PL. HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles. Genes Dev. 2014 Apr 15; 28(8):841-57. PMID: 24682306; PMCID: PMC4003277.
    45. Kotton DN, Rossant J. Modeling pulmonary alveolar proteinosis with induced pluripotent stem cells. Am J Respir Crit Care Med. 2014 Jan 15; 189(2):124-6. PMID: 24428646.
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    46. Posfai E, Tam OH, Rossant J. Mechanisms of pluripotency in vivo and in vitro. Curr Top Dev Biol. 2014; 107:1-37. PMID: 24439801.
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    47. Biechele S, Adissu HA, Cox BJ, Rossant J. Zygotic Porcn paternal allele deletion in mice to model human focal dermal hypoplasia. PLoS One. 2013; 8(11):e79139. PMID: 24223895; PMCID: PMC3815152.
    48. Rossant J. An interview with Janet Rossant. Interview by Catarina Vicente. Development. 2013 Nov; 140(21):4299-300. PMID: 24130326.
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    49. Li L, Liu C, Biechele S, Zhu Q, Song L, Lanner F, Jing N, Rossant J. Location of transient ectodermal progenitor potential in mouse development. Development. 2013 Nov; 140(22):4533-43. PMID: 24131634.
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    50. Rossant J. Making a knockout mouse: From stem cells to embryos. Nat Cell Biol. 2013 Oct; 15(10):1133. PMID: 24084859.
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    51. Anderson NM, Javadi M, Berndl E, Berberovic Z, Bailey ML, Huang K, Flenniken AM, Osborne LR, Adamson SL, Rossant J, Carter-Su C, Wang C, McNagny KM, Paulson RF, Minden MD, Stanford WL, Barber DL. Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele. PLoS One. 2013; 8(9):e75472. PMID: 24086539; PMCID: PMC3783367.
    52. Bernstein A, Rossant J. Anthony James Pawson (1952-2013). Nature. 2013 Sep 12; 501(7466):168. PMID: 24025833.
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    53. Kelsey L, Flenniken AM, Qu D, Funnell AP, Pearson R, Zhou YQ, Voronina I, Berberovic Z, Wood G, Newbigging S, Weiss ES, Wong M, Quach I, Yeh SY, Deshwar AR, Scott IC, McKerlie C, Henkelman M, Backx P, Simpson J, Osborne L, Rossant J, Crossley M, Bruneau B, Adamson SL. ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice. PLoS Genet. 2013; 9(7):e1003612. PMID: 23874215; PMCID: PMC3708807.
    54. Cockburn K, Biechele S, Garner J, Rossant J. The Hippo pathway member Nf2 is required for inner cell mass specification. Curr Biol. 2013 Jul 08; 23(13):1195-201. PMID: 23791728.
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    55. Biechele S, Cockburn K, Lanner F, Cox BJ, Rossant J. Porcn-dependent Wnt signaling is not required prior to mouse gastrulation. Development. 2013 Jul; 140(14):2961-71. PMID: 23760955.
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    56. Wong AP, Rossant J. Generation of Lung Epithelium from Pluripotent Stem Cells. Curr Pathobiol Rep. 2013 Jun; 1(2):137-145. PMID: 23662247.
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    57. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. PMID: 23607856.
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    58. Adams D, Baldock R, Bhattacharya S, Copp AJ, Dickinson M, Greene ND, Henkelman M, Justice M, Mohun T, Murray SA, Pauws E, Raess M, Rossant J, Weaver T, West D. Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening. Dis Model Mech. 2013 May; 6(3):571-9. PMID: 23519032.
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    59. Findlay GM, Smith MJ, Lanner F, Hsiung MS, Gish GD, Petsalaki E, Cockburn K, Kaneko T, Huang H, Bagshaw RD, Ketela T, Tucholska M, Taylor L, Bowtell DD, Moffat J, Ikura M, Li SS, Sidhu SS, Rossant J, Pawson T. Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate. Cell. 2013 Feb 28; 152(5):1008-20. PMID: 23452850.
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    60. Rossant J, Mummery C. NOBEL 2012 Physiology or medicine: Mature cells can be rejuvenated. Nature. 2012 Dec 06; 492(7427):56. PMID: 23222608.
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    61. Hirate Y, Cockburn K, Rossant J, Sasaki H. Tead4 is constitutively nuclear, while nuclear vs. cytoplasmic Yap distribution is regulated in preimplantation mouse embryos. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):E3389-90; author reply E3391-2. PMID: 23169672; PMCID: PMC3528498.
    62. Stephenson RO, Rossant J, Tam PP. Intercellular interactions, position, and polarity in establishing blastocyst cell lineages and embryonic axes. Cold Spring Harb Perspect Biol. 2012 Nov 01; 4(11). PMID: 23125013; PMCID: PMC3536338.
    63. Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J, Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M, Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K, Koutsourakis M, Lloyd KC, Marschall S, Mason J, McKerlie C, McLeod MP, von Melchner H, Moore M, Mujica AO, Nagy A, Nefedov M, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R, Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N, Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, Schofield P, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D, Stanford WL, Stewart AF, Stone K, Swan K, Tadepally H, Teboul L, Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura K, Yoshinaga Y, Wurst W. The mammalian gene function resource: the International Knockout Mouse Consortium. Mamm Genome. 2012 Oct; 23(9-10):580-6. PMID: 22968824; PMCID: PMC3463800.
    64. Wong AP, Bear CE, Chin S, Pasceri P, Thompson TO, Huan LJ, Ratjen F, Ellis J, Rossant J. Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein. Nat Biotechnol. 2012 Sep; 30(9):876-82. PMID: 22922672; PMCID: PMC3994104.
    65. Rossant J. Profile of Janet Rossant. Interview by Kristie Nybo. Biotechniques. 2012 Sep; 53(3):129. PMID: 22963472.
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    66. Owen C, Chen F, Flenniken AM, Osborne LR, Ichikawa S, Adamson SL, Rossant J, Aubin JE. A novel Phex mutation in a new mouse model of hypophosphatemic rickets. J Cell Biochem. 2012 Jul; 113(7):2432-41. PMID: 22573557.
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    67. Blanpain C, Daley GQ, Hochedlinger K, Passegué E, Rossant J, Yamanaka S. Stem cells assessed. Nat Rev Mol Cell Biol. 2012 06 08; 13(7):471-6. PMID: 22678486.
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    68. Rugg-Gunn PJ, Cox BJ, Lanner F, Sharma P, Ignatchenko V, McDonald AC, Garner J, Gramolini AO, Rossant J, Kislinger T. Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells. Dev Cell. 2012 Apr 17; 22(4):887-901. PMID: 22424930.
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    69. Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H, Baker J, Baker D, Munoz MB, Beil S, Benvenisty N, Ben-Yosef D, Biancotti JC, Bosman A, Brena RM, Brison D, Caisander G, Camarasa MV, Chen J, Chiao E, Choi YM, Choo AB, Collins D, Colman A, Crook JM, Daley GQ, Dalton A, De Sousa PA, Denning C, Downie J, Dvorak P, Montgomery KD, Feki A, Ford A, Fox V, Fraga AM, Frumkin T, Ge L, Gokhale PJ, Golan-Lev T, Gourabi H, Gropp M, Lu G, Hampl A, Harron K, Healy L, Herath W, Holm F, Hovatta O, Hyllner J, Inamdar MS, Irwanto AK, Ishii T, Jaconi M, Jin Y, Kimber S, Kiselev S, Knowles BB, Kopper O, Kukharenko V, Kuliev A, Lagarkova MA, Laird PW, Lako M, Laslett AL, Lavon N, Lee DR, Lee JE, Li C, Lim LS, Ludwig TE, Ma Y, Maltby E, Mateizel I, Mayshar Y, Mileikovsky M, Minger SL, Miyazaki T, Moon SY, Moore H, Mummery C, Nagy A, Nakatsuji N, Narwani K, Oh SK, Oh SK, Olson C, Otonkoski T, Pan F, Park IH, Pells S, Pera MF, Pereira LV, Qi O, Raj GS, Reubinoff B, Robins A, Robson P, Rossant J, Salekdeh GH, Schulz TC, Sermon K, Sheik Mohamed J, Shen H, Sherrer E, Sidhu K, Sivarajah S, Skottman H, Spits C, Stacey GN, Strehl R, Strelchenko N, Suemori H, Sun B, Suuronen R, Takahashi K, Tuuri T, Venu P, Verlinsky Y, Ward-van Oostwaard D, Weisenberger DJ, Wu Y, Yamanaka S, Young L, Zhou Q. Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol. 2011 Nov 27; 29(12):1132-44. PMID: 22119741; PMCID: PMC3454460.
    70. McCann MR, Tamplin OJ, Rossant J, Séguin CA. Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development. Dis Model Mech. 2012 Jan; 5(1):73-82. PMID: 22028328; PMCID: PMC3255545.
    71. Paca A, Séguin CA, Clements M, Ryczko M, Rossant J, Rodriguez TA, Kunath T. BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm. Dev Biol. 2012 Jan 01; 361(1):90-102. PMID: 22027433.
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    72. Cox B, Sharma P, Evangelou AI, Whiteley K, Ignatchenko V, Ignatchenko A, Baczyk D, Czikk M, Kingdom J, Rossant J, Gramolini AO, Adamson SL, Kislinger T. Translational analysis of mouse and human placental protein and mRNA reveals distinct molecular pathologies in human preeclampsia. Mol Cell Proteomics. 2011 Dec; 10(12):M111.012526. PMID: 21986993; PMCID: PMC3237089.
    73. Tamplin OJ, Cox BJ, Rossant J. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Dev Biol. 2011 Dec 15; 360(2):415-25. PMID: 22008794.
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    74. Anderson NM, Berberovic Z, Berndl E, Bailey ML, Flenniken AM, Osborne LR, Adamson SL, Rossant J, Wang C, Minden MD, McNagny KM, Paulson RF, Barber DL, Stanford WL. Cytopenia induction by 5-fluorouracil identifies thrombopoietic mutants in sensitized ENU mutagenesis screens. Exp Hematol. 2012 Jan; 40(1):48-60. PMID: 21924221; PMCID: PMC3341667.
    75. Rossant J. The impact of developmental biology on pluripotent stem cell research: successes and challenges. Dev Cell. 2011 Jul 19; 21(1):20-3. PMID: 21763602.
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    76. Ochotny N, Flenniken AM, Owen C, Voronov I, Zirngibl RA, Osborne LR, Henderson JE, Adamson SL, Rossant J, Manolson MF, Aubin JE. The V-ATPase a3 subunit mutation R740S is dominant negative and results in osteopetrosis in mice. J Bone Miner Res. 2011 Jul; 26(7):1484-93. PMID: 21305608.
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    77. Wright JG, Daneman D, Mainland J, Rossant J. Innovation as the core strategy for the future success of academic health centres. Can J Surg. 2011 Jun; 54(3):150-1. PMID: 21443830; PMCID: PMC3104316.
    78. Biechele S, Cox BJ, Rossant J. Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos. Dev Biol. 2011 Jul 15; 355(2):275-85. PMID: 21554866.
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    79. Rossant J, Nutter LM, Gertsenstein M. Engineering the embryo. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7659-60. PMID: 21527721; PMCID: PMC3093494.
    80. Rossant J. Developmental biology: A mouse is not a cow. Nature. 2011 Mar 24; 471(7339):457-8. PMID: 21430771.
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    81. Ly JP, Onay T, Sison K, Sivaskandarajah G, Sabbisetti V, Li L, Bonventre JV, Flenniken A, Paragas N, Barasch JM, Adamson SL, Osborne L, Rossant J, Schnermann J, Quaggin SE. The Sweet Pee model for Sglt2 mutation. J Am Soc Nephrol. 2011 Jan; 22(1):113-23. PMID: 21209254; PMCID: PMC3014040.
    82. Hughes MR, Anderson N, Maltby S, Wong J, Berberovic Z, Birkenmeier CS, Haddon DJ, Garcha K, Flenniken A, Osborne LR, Adamson SL, Rossant J, Peters LL, Minden MD, Paulson RF, Wang C, Barber DL, McNagny KM, Stanford WL. A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis. Exp Hematol. 2011 Mar; 39(3):305-20, 320.e1-2. PMID: 21193012; PMCID: PMC3404605.
    83. Varelas X, Samavarchi-Tehrani P, Narimatsu M, Weiss A, Cockburn K, Larsen BG, Rossant J, Wrana JL. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-ß-SMAD pathway. Dev Cell. 2010 Dec 14; 19(6):831-44. PMID: 21145499.
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    84. Lanner F, Rossant J. The role of FGF/Erk signaling in pluripotent cells. Development. 2010 Oct; 137(20):3351-60. PMID: 20876656.
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    85. Stephenson RO, Yamanaka Y, Rossant J. Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin. Development. 2010 Oct; 137(20):3383-91. PMID: 20826529.
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    86. Gertsenstein M, Nutter LM, Reid T, Pereira M, Stanford WL, Rossant J, Nagy A. Efficient generation of germ line transmitting chimeras from C57BL/6N ES cells by aggregation with outbred host embryos. PLoS One. 2010 Jun 22; 5(6):e11260. PMID: 20582321; PMCID: PMC2889837.
    87. Cox BJ, Vollmer M, Tamplin O, Lu M, Biechele S, Gertsenstein M, van Campenhout C, Floss T, Kühn R, Wurst W, Lickert H, Rossant J. Phenotypic annotation of the mouse X chromosome. Genome Res. 2010 Aug; 20(8):1154-64. PMID: 20548051; PMCID: PMC2909578.
    88. Mai S, Wei K, Flenniken A, Adamson SL, Rossant J, Aubin JE, Gong SG. The missense mutation W290R in Fgfr2 causes developmental defects from aberrant IIIb and IIIc signaling. Dev Dyn. 2010 Jun; 239(6):1888-900. PMID: 20503384.
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    89. Zhang K, Li L, Huang C, Shen C, Tan F, Xia C, Liu P, Rossant J, Jing N. Distinct functions of BMP4 during different stages of mouse ES cell neural commitment. Development. 2010 Jul; 137(13):2095-105. PMID: 20504958.
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    90. Rugg-Gunn PJ, Cox BJ, Ralston A, Rossant J. Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):10783-90. PMID: 20479220; PMCID: PMC2890770.
    91. Ahmed K, Dehghani H, Rugg-Gunn P, Fussner E, Rossant J, Bazett-Jones DP. Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo. PLoS One. 2010 May 07; 5(5):e10531. PMID: 20479880; PMCID: PMC2866533.
    92. Cockburn K, Rossant J. Making the blastocyst: lessons from the mouse. J Clin Invest. 2010 Apr; 120(4):995-1003. PMID: 20364097; PMCID: PMC2846056.
    93. Coultas L, Nieuwenhuis E, Anderson GA, Cabezas J, Nagy A, Henkelman RM, Hui CC, Rossant J. Hedgehog regulates distinct vascular patterning events through VEGF-dependent and -independent mechanisms. Blood. 2010 Jul 29; 116(4):653-60. PMID: 20339091.
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    94. Andrews PW, Benvenisty N, Knowles BB, McKay RD, Oh SK, Pera MF, Rossant J, Stacey GN. Human ES cell lines--introduction. In Vitro Cell Dev Biol Anim. 2010 Apr; 46(3-4):167-8. PMID: 20213278.
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    95. Yamanaka Y, Lanner F, Rossant J. FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst. Development. 2010 Mar; 137(5):715-24. PMID: 20147376.
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    96. Akopian V, Andrews PW, Beil S, Benvenisty N, Brehm J, Christie M, Ford A, Fox V, Gokhale PJ, Healy L, Holm F, Hovatta O, Knowles BB, Ludwig TE, McKay RD, Miyazaki T, Nakatsuji N, Oh SK, Pera MF, Rossant J, Stacey GN, Suemori H. Comparison of defined culture systems for feeder cell free propagation of human embryonic stem cells. In Vitro Cell Dev Biol Anim. 2010 Apr; 46(3-4):247-58. PMID: 20186512; PMCID: PMC2855804.
    97. Ralston A, Cox BJ, Nishioka N, Sasaki H, Chea E, Rugg-Gunn P, Guo G, Robson P, Draper JS, Rossant J. Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2. Development. 2010 Feb; 137(3):395-403. PMID: 20081188.
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    98. Lanner F, Lee KL, Sohl M, Holmborn K, Yang H, Wilbertz J, Poellinger L, Rossant J, Farnebo F. Heparan sulfation-dependent fibroblast growth factor signaling maintains embryonic stem cells primed for differentiation in a heterogeneous state. Stem Cells. 2010 Feb; 28(2):191-200. PMID: 19937756.
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    99. Ralston A, Rossant J. The genetics of induced pluripotency. Reproduction. 2010 Jan; 139(1):35-44. PMID: 19605512.
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    100. Rossant J. A developmental journey and lessons learned along the way. Mol Biol Cell. 2010 Jan 01; 21(1):9-10. PMID: 20048257.
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    101. Zarzeczny A, Scott C, Hyun I, Bennett J, Chandler J, Chargé S, Heine H, Isasi R, Kato K, Lovell-Badge R, McNagny K, Pei D, Rossant J, Surani A, Taylor PL, Ogbogu U, Caulfield T. iPS cells: mapping the policy issues. Cell. 2009 Dec 11; 139(6):1032-7. PMID: 20005794.
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    102. Xu K, Nieuwenhuis E, Cohen BL, Wang W, Canty AJ, Danska JS, Coultas L, Rossant J, Wu MY, Piscione TD, Nagy A, Gossler A, Hicks GG, Hui CC, Henkelman RM, Yu LX, Sled JG, Gridley T, Egan SE. Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis. Am J Physiol Lung Cell Mol Physiol. 2010 Jan; 298(1):L45-56. PMID: 19897741; PMCID: PMC2806195.
    103. Rossant J. Reprogramming to pluripotency: from frogs to stem cells. Cell. 2009 Sep 18; 138(6):1047-50. PMID: 19766555.
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    104. Cox B, Kotlyar M, Evangelou AI, Ignatchenko V, Ignatchenko A, Whiteley K, Jurisica I, Adamson SL, Rossant J, Kislinger T. Comparative systems biology of human and mouse as a tool to guide the modeling of human placental pathology. Mol Syst Biol. 2009; 5:279. PMID: 19536202; PMCID: PMC2710868.
    105. Hotta A, Cheung AY, Farra N, Vijayaragavan K, Séguin CA, Draper JS, Pasceri P, Maksakova IA, Mager DL, Rossant J, Bhatia M, Ellis J. Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency. Nat Methods. 2009 May; 6(5):370-6. PMID: 19404254.
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    106. Rugg-Gunn PJ, Ogbogu U, Rossant J, Caulfield T. The challenge of regulating rapidly changing science: stem cell legislation in Canada. Cell Stem Cell. 2009 Apr 03; 4(4):285-8. PMID: 19341618.
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    107. Ellis J, Bruneau BG, Keller G, Lemischka IR, Nagy A, Rossant J, Srivastava D, Zandstra PW, Stanford WL. Alternative induced pluripotent stem cell characterization criteria for in vitro applications. Cell Stem Cell. 2009 Mar 06; 4(3):198-9; author reply 202. PMID: 19265656.
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    108. Nishioka N, Inoue K, Adachi K, Kiyonari H, Ota M, Ralston A, Yabuta N, Hirahara S, Stephenson RO, Ogonuki N, Makita R, Kurihara H, Morin-Kensicki EM, Nojima H, Rossant J, Nakao K, Niwa H, Sasaki H. The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev Cell. 2009 Mar; 16(3):398-410. PMID: 19289085.
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    109. Rossant J, Tam PP. Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development. 2009 Mar; 136(5):701-13. PMID: 19201946.
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    110. Benedito R, Trindade A, Hirashima M, Henrique D, da Costa LL, Rossant J, Gill PS, Duarte A. Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli. BMC Dev Biol. 2008 Dec 16; 8:117. PMID: 19087347; PMCID: PMC2637862.
    111. Ema M, Mori D, Niwa H, Hasegawa Y, Yamanaka Y, Hitoshi S, Mimura J, Kawabe Y, Hosoya T, Morita M, Shimosato D, Uchida K, Suzuki N, Yanagisawa J, Sogawa K, Rossant J, Yamamoto M, Takahashi S, Fujii-Kuriyama Y. Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs. Cell Stem Cell. 2008 Nov 06; 3(5):555-67. PMID: 18983969.
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    112. Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008 Oct 30; 9:511. PMID: 18973680; PMCID: PMC2605479.
    113. Séguin CA, Draper JS, Nagy A, Rossant J. Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells. Cell Stem Cell. 2008 Aug 07; 3(2):182-95. PMID: 18682240.
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    114. Walls JR, Coultas L, Rossant J, Henkelman RM. Three-dimensional analysis of vascular development in the mouse embryo. PLoS One. 2008 Aug 06; 3(8):e2853. PMID: 18682734; PMCID: PMC2478714.
    115. Malaval L, Wade-Guéye NM, Boudiffa M, Fei J, Zirngibl R, Chen F, Laroche N, Roux JP, Burt-Pichat B, Duboeuf F, Boivin G, Jurdic P, Lafage-Proust MH, Amédée J, Vico L, Rossant J, Aubin JE. Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis. J Exp Med. 2008 May 12; 205(5):1145-53. PMID: 18458111; PMCID: PMC2373846.
    116. Rossant J. Stem cells and early lineage development. Cell. 2008 Feb 22; 132(4):527-31. PMID: 18295568.
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    117. Hirashima M, Sano K, Morisada T, Murakami K, Rossant J, Suda T. Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos. Dev Biol. 2008 Apr 01; 316(1):149-59. PMID: 18304521.
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    118. Yamanaka Y, Tamplin OJ, Beckers A, Gossler A, Rossant J. Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms. Dev Cell. 2007 Dec; 13(6):884-96. PMID: 18061569.
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    119. Ralston A, Rossant J. Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo. Dev Biol. 2008 Jan 15; 313(2):614-29. PMID: 18067887.
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    120. Gerbe F, Cox B, Rossant J, Chazaud C. Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst. Dev Biol. 2008 Jan 15; 313(2):594-602. PMID: 18083160.
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    121. Shawber CJ, Funahashi Y, Francisco E, Vorontchikhina M, Kitamura Y, Stowell SA, Borisenko V, Feirt N, Podgrabinska S, Shiraishi K, Chawengsaksophak K, Rossant J, Accili D, Skobe M, Kitajewski J. Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin Invest. 2007 Nov; 117(11):3369-82. PMID: 17948123; PMCID: PMC2030453.
    122. Rossant J, Hogan B. Retrospective. Anne McLaren (1927-2007). Science. 2007 Aug 03; 317(5838):609. PMID: 17673646.
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    123. Rossant J. Stem cells: the magic brew. Nature. 2007 Jul 19; 448(7151):260-2. PMID: 17637646.
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    124. Adewumi O, Aflatoonian B, Ahrlund-Richter L, Amit M, Andrews PW, Beighton G, Bello PA, Benvenisty N, Berry LS, Bevan S, Blum B, Brooking J, Chen KG, Choo AB, Churchill GA, Corbel M, Damjanov I, Draper JS, Dvorak P, Emanuelsson K, Fleck RA, Ford A, Gertow K, Gertsenstein M, Gokhale PJ, Hamilton RS, Hampl A, Healy LE, Hovatta O, Hyllner J, Imreh MP, Itskovitz-Eldor J, Jackson J, Johnson JL, Jones M, Kee K, King BL, Knowles BB, Lako M, Lebrin F, Mallon BS, Manning D, Mayshar Y, McKay RD, Michalska AE, Mikkola M, Mileikovsky M, Minger SL, Moore HD, Mummery CL, Nagy A, Nakatsuji N, O'Brien CM, Oh SK, Olsson C, Otonkoski T, Park KY, Passier R, Patel H, Patel M, Pedersen R, Pera MF, Piekarczyk MS, Pera RA, Reubinoff BE, Robins AJ, Rossant J, Rugg-Gunn P, Schulz TC, Semb H, Sherrer ES, Siemen H, Stacey GN, Stojkovic M, Suemori H, Szatkiewicz J, Turetsky T, Tuuri T, van den Brink S, Vintersten K, Vuoristo S, Ward D, Weaver TA, Young LA, Zhang W. Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol. 2007 Jul; 25(7):803-16. PMID: 17572666.
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    125. Karpowicz P, Inoue T, Runciman S, Deveale B, Seaberg R, Gertsenstein M, Byers L, Yamanaka Y, Tondat S, Slevin J, Hitoshi S, Rossant J, van der Kooy D. Adhesion is prerequisite, but alone insufficient, to elicit stem cell pluripotency. J Neurosci. 2007 May 16; 27(20):5437-47. PMID: 17507566.
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    126. Cox B, Kislinger T, Wigle DA, Kannan A, Brown K, Okubo T, Hogan B, Jurisica I, Frey B, Rossant J, Emili A. Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes. Mol Syst Biol. 2007; 3:109. PMID: 17486137; PMCID: PMC2673710.
    127. Collins FS, Finnell RH, Rossant J, Wurst W. A new partner for the international knockout mouse consortium. Cell. 2007 Apr 20; 129(2):235. PMID: 17448981.
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    128. Kimura-Yoshida C, Tian E, Nakano H, Amazaki S, Shimokawa K, Rossant J, Aizawa S, Matsuo I. Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes. Proc Natl Acad Sci U S A. 2007 Apr 03; 104(14):5919-24. PMID: 17389379; PMCID: PMC1851592.
    129. Xie G, Clapcote SJ, Nieman BJ, Tallerico T, Huang Y, Vukobradovic I, Cordes SP, Osborne LR, Rossant J, Sled JG, Henderson JT, Roder JC. Forward genetic screen of mouse reveals dominant missense mutation in the P/Q-type voltage-dependent calcium channel, CACNA1A. Genes Brain Behav. 2007 Nov; 6(8):717-27. PMID: 17376154.
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    130. Georgiades P, Cox B, Gertsenstein M, Chawengsaksophak K, Rossant J. Trophoblast-specific gene manipulation using lentivirus-based vectors. Biotechniques. 2007 Mar; 42(3):317-8, 320, 322-5. PMID: 17390538.
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    131. Daley GQ, Ahrlund Richter L, Auerbach JM, Benvenisty N, Charo RA, Chen G, Deng HK, Goldstein LS, Hudson KL, Hyun I, Junn SC, Love J, Lee EH, McLaren A, Mummery CL, Nakatsuji N, Racowsky C, Rooke H, Rossant J, Schöler HR, Solbakk JH, Taylor P, Trounson AO, Weissman IL, Wilmut I, Yu J, Zoloth L. Ethics. The ISSCR guidelines for human embryonic stem cell research. Science. 2007 Feb 02; 315(5812):603-4. PMID: 17272706.
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    132. Hellström M, Phng LK, Hofmann JJ, Wallgard E, Coultas L, Lindblom P, Alva J, Nilsson AK, Karlsson L, Gaiano N, Yoon K, Rossant J, Iruela-Arispe ML, Kalén M, Gerhardt H, Betsholtz C. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature. 2007 Feb 15; 445(7129):776-80. PMID: 17259973.
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    133. Collins FS, Rossant J, Wurst W. A mouse for all reasons. Cell. 2007 Jan 12; 128(1):9-13. PMID: 17218247.
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    134. Takeuchi JK, Lickert H, Bisgrove BW, Sun X, Yamamoto M, Chawengsaksophak K, Hamada H, Yost HJ, Rossant J, Bruneau BG. Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):846-51. PMID: 17210915; PMCID: PMC1783402.
    135. Rossant J. Stem cells and lineage development in the mammalian blastocyst. Reprod Fertil Dev. 2007; 19(1):111-8. PMID: 17389140.
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    136. Zhang W, Walker E, Tamplin OJ, Rossant J, Stanford WL, Hughes TR. Zfp206 regulates ES cell gene expression and differentiation. Nucleic Acids Res. 2006; 34(17):4780-90. PMID: 16971461; PMCID: PMC1635278.
    137. Yamanaka Y, Ralston A, Stephenson RO, Rossant J. Cell and molecular regulation of the mouse blastocyst. Dev Dyn. 2006 Sep; 235(9):2301-14. PMID: 16773657.
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    138. Chazaud C, Rossant J. Disruption of early proximodistal patterning and AVE formation in Apc mutants. Development. 2006 Sep; 133(17):3379-87. PMID: 16887818.
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    139. Rossant J. Culturing Trophoblast Stem (TS) Cell Lines. CSH Protoc. 2006 Jul 01; 2006(2). PMID: 22485816.
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    140. Rossant J. Derivation of Trophoblast Stem (TS) Cell Lines from Blastocysts. CSH Protoc. 2006 Jul 01; 2006(2). PMID: 22485817.
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    141. Wada T, Haigh JJ, Ema M, Hitoshi S, Chaddah R, Rossant J, Nagy A, van der Kooy D. Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival. J Neurosci. 2006 Jun 21; 26(25):6803-12. PMID: 16793887.
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    142. Chazaud C, Yamanaka Y, Pawson T, Rossant J. Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway. Dev Cell. 2006 May; 10(5):615-24. PMID: 16678776.
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    143. Kislinger T, Cox B, Kannan A, Chung C, Hu P, Ignatchenko A, Scott MS, Gramolini AO, Morris Q, Hallett MT, Rossant J, Hughes TR, Frey B, Emili A. Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling. Cell. 2006 Apr 07; 125(1):173-86. PMID: 16615898.
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    144. Spradling A, Ganetsky B, Hieter P, Johnston M, Olson M, Orr-Weaver T, Rossant J, Sanchez A, Waterston R. New roles for model genetic organisms in understanding and treating human disease: report from the 2006 Genetics Society of America meeting. Genetics. 2006 Apr; 172(4):2025-32. PMID: 16636111; PMCID: PMC1456383.
    145. Takaoka K, Yamamoto M, Shiratori H, Meno C, Rossant J, Saijoh Y, Hamada H. The mouse embryo autonomously acquires anterior-posterior polarity at implantation. Dev Cell. 2006 Apr; 10(4):451-9. PMID: 16580991.
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    146. Bowles J, Knight D, Smith C, Wilhelm D, Richman J, Mamiya S, Yashiro K, Chawengsaksophak K, Wilson MJ, Rossant J, Hamada H, Koopman P. Retinoid signaling determines germ cell fate in mice. Science. 2006 Apr 28; 312(5773):596-600. PMID: 16574820.
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    147. Ralston A, Rossant J. How signaling promotes stem cell survival: trophoblast stem cells and Shp2. Dev Cell. 2006 Mar; 10(3):275-6. PMID: 16516829.
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    148. Slevin JC, Byers L, Gertsenstein M, Qu D, Mu J, Sunn N, Kingdom JC, Rossant J, Adamson SL. High resolution ultrasound-guided microinjection for interventional studies of early embryonic and placental development in vivo in mice. BMC Dev Biol. 2006 Feb 27; 6:10. PMID: 16504164; PMCID: PMC1436015.
    149. Georgiades P, Rossant J. Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development. Development. 2006 Mar; 133(6):1059-68. PMID: 16481355.
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    150. Eremina V, Cui S, Gerber H, Ferrara N, Haigh J, Nagy A, Ema M, Rossant J, Jothy S, Miner JH, Quaggin SE. Vascular endothelial growth factor a signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival. J Am Soc Nephrol. 2006 Mar; 17(3):724-35. PMID: 16436493.
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    151. Zhao H, Yang Y, Partanen J, Ciruna BG, Rossant J, Robinson ML. Fibroblast growth factor receptor 1 (Fgfr1) is not essential for lens fiber differentiation in mice. Mol Vis. 2006 Jan 10; 12:15-25. PMID: 16446698; PMCID: PMC4280232.
    152. Nord AS, Chang PJ, Conklin BR, Cox AV, Harper CA, Hicks GG, Huang CC, Johns SJ, Kawamoto M, Liu S, Meng EC, Morris JH, Rossant J, Ruiz P, Skarnes WC, Soriano P, Stanford WL, Stryke D, von Melchner H, Wurst W, Yamamura K, Young SG, Babbitt PC, Ferrin TE. The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res. 2006 Jan 01; 34(Database issue):D642-8. PMID: 16381950; PMCID: PMC1347459.
    153. Quinn J, Kunath T, Rossant J. Mouse trophoblast stem cells. Methods Mol Med. 2006; 121:125-48. PMID: 16251740.
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    154. Stanford WL, Epp T, Reid T, Rossant J. Gene trapping in embryonic stem cells. Methods Enzymol. 2006; 420:136-62. PMID: 17161697.
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    155. Coultas L, Chawengsaksophak K, Rossant J. Endothelial cells and VEGF in vascular development. Nature. 2005 Dec 15; 438(7070):937-45. PMID: 16355211.
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    156. Niwa H, Toyooka Y, Shimosato D, Strumpf D, Takahashi K, Yagi R, Rossant J. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell. 2005 Dec 02; 123(5):917-29. PMID: 16325584.
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    157. Nieman BJ, Bock NA, Bishop J, Chen XJ, Sled JG, Rossant J, Henkelman RM. Magnetic resonance imaging for detection and analysis of mouse phenotypes. NMR Biomed. 2005 Nov; 18(7):447-68. PMID: 16206127.
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    158. Flenniken AM, Osborne LR, Anderson N, Ciliberti N, Fleming C, Gittens JE, Gong XQ, Kelsey LB, Lounsbury C, Moreno L, Nieman BJ, Peterson K, Qu D, Roscoe W, Shao Q, Tong D, Veitch GI, Voronina I, Vukobradovic I, Wood GA, Zhu Y, Zirngibl RA, Aubin JE, Bai D, Bruneau BG, Grynpas M, Henderson JE, Henkelman RM, McKerlie C, Sled JG, Stanford WL, Laird DW, Kidder GM, Adamson SL, Rossant J. A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development. 2005 Oct; 132(19):4375-86. PMID: 16155213.
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    159. Ema M, Takahashi S, Rossant J. Deletion of the selection cassette, but not cis-acting elements, in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors. Blood. 2006 Jan 01; 107(1):111-7. PMID: 16166582.
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    160. Frey BJ, Mohammad N, Morris QD, Zhang W, Robinson MD, Mnaimneh S, Chang R, Pan Q, Sat E, Rossant J, Bruneau BG, Aubin JE, Blencowe BJ, Hughes TR. Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs. Nat Genet. 2005 Sep; 37(9):991-6. PMID: 16127451.
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    161. Ralston A, Rossant J. Genetic regulation of stem cell origins in the mouse embryo. Clin Genet. 2005 Aug; 68(2):106-12. PMID: 15996204.
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    162. Andrews PW, Benvenisty N, McKay R, Pera MF, Rossant J, Semb H, Stacey GN. The International Stem Cell Initiative: toward benchmarks for human embryonic stem cell research. Nat Biotechnol. 2005 Jul; 23(7):795-7. PMID: 16003358.
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    163. Wood GA, Flenniken A, Osborne L, Fleming C, Vukobradovic I, Morikawa L, Xu Q, Porter R, Adamson SL, Rossant J, McKerlie C. Two mouse mutations mapped to chromosome 11 with differing morphologies but similar progressive inflammatory alopecia. Exp Dermatol. 2005 May; 14(5):373-9. PMID: 15854131.
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    164. Lickert H, Cox B, Wehrle C, Taketo MM, Kemler R, Rossant J. Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos. Development. 2005 Jun; 132(11):2599-609. PMID: 15857914.
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    165. Kunath T, Arnaud D, Uy GD, Okamoto I, Chureau C, Yamanaka Y, Heard E, Gardner RL, Avner P, Rossant J. Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts. Development. 2005 Apr; 132(7):1649-61. PMID: 15753215.
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    166. Strumpf D, Mao CA, Yamanaka Y, Ralston A, Chawengsaksophak K, Beck F, Rossant J. Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development. 2005 May; 132(9):2093-102. PMID: 15788452.
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    167. Zhang W, Morris QD, Chang R, Shai O, Bakowski MA, Mitsakakis N, Mohammad N, Robinson MD, Zirngibl R, Somogyi E, Laurin N, Eftekharpour E, Sat E, Grigull J, Pan Q, Peng WT, Krogan N, Greenblatt J, Fehlings M, van der Kooy D, Aubin J, Bruneau BG, Rossant J, Blencowe BJ, Frey BJ, Hughes TR. The functional landscape of mouse gene expression. J Biol. 2004; 3(5):21. PMID: 15588312; PMCID: PMC549719.
    168. Lickert H, Takeuchi JK, Von Both I, Walls JR, McAuliffe F, Adamson SL, Henkelman RM, Wrana JL, Rossant J, Bruneau BG. Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Nature. 2004 Nov 04; 432(7013):107-12. PMID: 15525990.
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    169. Duarte A, Hirashima M, Benedito R, Trindade A, Diniz P, Bekman E, Costa L, Henrique D, Rossant J. Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev. 2004 Oct 15; 18(20):2474-8. PMID: 15466159; PMCID: PMC529534.
    170. Rossant J. Lineage development and polar asymmetries in the peri-implantation mouse blastocyst. Semin Cell Dev Biol. 2004 Oct; 15(5):573-81. PMID: 15271303.
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    171. Clark AT, Goldowitz D, Takahashi JS, Vitaterna MH, Siepka SM, Peters LL, Frankel WN, Carlson GA, Rossant J, Nadeau JH, Justice MJ. Implementing large-scale ENU mutagenesis screens in North America. Genetica. 2004 Sep; 122(1):51-64. PMID: 15619961; PMCID: PMC3774779.
    172. Kibschull M, Nassiry M, Dunk C, Gellhaus A, Quinn JA, Rossant J, Lye SJ, Winterhager E. Connexin31-deficient trophoblast stem cells: a model to analyze the role of gap junction communication in mouse placental development. Dev Biol. 2004 Sep 01; 273(1):63-75. PMID: 15302598.
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    173. von Both I, Silvestri C, Erdemir T, Lickert H, Walls JR, Henkelman RM, Rossant J, Harvey RP, Attisano L, Wrana JL. Foxh1 is essential for development of the anterior heart field. Dev Cell. 2004 Sep; 7(3):331-45. PMID: 15363409.
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    174. Rossant J, Tam PP. Emerging asymmetry and embryonic patterning in early mouse development. Dev Cell. 2004 Aug; 7(2):155-64. PMID: 15296713.
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    175. Nishimura T, Dunk C, Lu Y, Feng X, Gellhaus A, Winterhager E, Rossant J, Lye SJ. Gap junctions are required for trophoblast proliferation in early human placental development. Placenta. 2004 Aug; 25(7):595-607. PMID: 15193866.
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    176. Abdelkhalek HB, Beckers A, Schuster-Gossler K, Pavlova MN, Burkhardt H, Lickert H, Rossant J, Reinhardt R, Schalkwyk LC, Müller I, Herrmann BG, Ceolin M, Rivera-Pomar R, Gossler A. The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes Dev. 2004 Jul 15; 18(14):1725-36. PMID: 15231714; PMCID: PMC478193.
    177. Skarnes WC, von Melchner H, Wurst W, Hicks G, Nord AS, Cox T, Young SG, Ruiz P, Soriano P, Tessier-Lavigne M, Conklin BR, Stanford WL, Rossant J. A public gene trap resource for mouse functional genomics. Nat Genet. 2004 Jun; 36(6):543-4. PMID: 15167922.
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    178. Chawengsaksophak K, de Graaff W, Rossant J, Deschamps J, Beck F. Cdx2 is essential for axial elongation in mouse development. Proc Natl Acad Sci U S A. 2004 May 18; 101(20):7641-5. PMID: 15136723; PMCID: PMC419659.
    179. Myers AP, Corson LB, Rossant J, Baker JC. Characterization of mouse Rsk4 as an inhibitor of fibroblast growth factor-RAS-extracellular signal-regulated kinase signaling. Mol Cell Biol. 2004 May; 24(10):4255-66. PMID: 15121846; PMCID: PMC400469.
    180. Hirashima M, Bernstein A, Stanford WL, Rossant J. Gene-trap expression screening to identify endothelial-specific genes. Blood. 2004 Aug 01; 104(3):711-8. PMID: 15090446.
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    181. Kunath T, Strumpf D, Rossant J. Early trophoblast determination and stem cell maintenance in the mouse--a review. Placenta. 2004 Apr; 25 Suppl A:S32-8. PMID: 15033304.
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    182. To C, Epp T, Reid T, Lan Q, Yu M, Li CY, Ohishi M, Hant P, Tsao N, Casallo G, Rossant J, Osborne LR, Stanford WL. The Centre for Modeling Human Disease Gene Trap resource. Nucleic Acids Res. 2004 Jan 01; 32(Database issue):D557-9. PMID: 14681480; PMCID: PMC308840.
    183. Sharov AA, Piao Y, Matoba R, Dudekula DB, Qian Y, VanBuren V, Falco G, Martin PR, Stagg CA, Bassey UC, Wang Y, Carter MG, Hamatani T, Aiba K, Akutsu H, Sharova L, Tanaka TS, Kimber WL, Yoshikawa T, Jaradat SA, Pantano S, Nagaraja R, Boheler KR, Taub D, Hodes RJ, Longo DL, Schlessinger D, Keller J, Klotz E, Kelsoe G, Umezawa A, Vescovi AL, Rossant J, Kunath T, Hogan BL, Curci A, D'Urso M, Kelso J, Hide W, Ko MS. Transcriptome analysis of mouse stem cells and early embryos. PLoS Biol. 2003 Dec; 1(3):E74. PMID: 14691545; PMCID: PMC300684.
    184. Hirashima M, Lu Y, Byers L, Rossant J. Trophoblast expression of fms-like tyrosine kinase 1 is not required for the establishment of the maternal-fetal interface in the mouse placenta. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15637-42. PMID: 14668430; PMCID: PMC307620.
    185. Dunk C, Petkovic L, Baczyk D, Rossant J, Winterhager E, Lye S. A novel in vitro model of trophoblast-mediated decidual blood vessel remodeling. Lab Invest. 2003 Dec; 83(12):1821-8. PMID: 14691300.
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    186. Tam PP, Rossant J. Mouse embryonic chimeras: tools for studying mammalian development. Development. 2003 Dec; 130(25):6155-63. PMID: 14623817.
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    187. Pearce EL, Mullen AC, Martins GA, Krawczyk CM, Hutchins AS, Zediak VP, Banica M, DiCioccio CB, Gross DA, Mao CA, Shen H, Cereb N, Yang SY, Lindsten T, Rossant J, Hunter CA, Reiner SL. Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science. 2003 Nov 07; 302(5647):1041-3. PMID: 14605368.
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    188. Haigh JJ, Ema M, Haigh K, Gertsenstein M, Greer P, Rossant J, Nagy A, Wagner EF. Activated Fps/Fes partially rescues the in vivo developmental potential of Flk1-deficient vascular progenitor cells. Blood. 2004 Feb 01; 103(3):912-20. PMID: 14525765.
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    189. Corson LB, Yamanaka Y, Lai KM, Rossant J. Spatial and temporal patterns of ERK signaling during mouse embryogenesis. Development. 2003 Oct; 130(19):4527-37. PMID: 12925581.
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    190. Rossant J. Genetics: a balancing act. Nature. 2003 Sep 04; 425(6953):29-32. PMID: 12955124.
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    191. Rossant J, Chazaud C, Yamanaka Y. Lineage allocation and asymmetries in the early mouse embryo. Philos Trans R Soc Lond B Biol Sci. 2003 Aug 29; 358(1436):1341-8; discussion 1349. PMID: 14511480; PMCID: PMC1693231.
    192. Rossant J, Hirashima M. Vascular development and patterning: making the right choices. Curr Opin Genet Dev. 2003 Aug; 13(4):408-12. PMID: 12888015.
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    193. Ema M, Rossant J. Cell fate decisions in early blood vessel formation. Trends Cardiovasc Med. 2003 Aug; 13(6):254-9. PMID: 12922023.
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    194. Bachiller D, Klingensmith J, Shneyder N, Tran U, Anderson R, Rossant J, De Robertis EM. The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome. Development. 2003 Aug; 130(15):3567-78. PMID: 12810603.
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    195. Chazaud C, Dollé P, Rossant J, Mollard R. Retinoic acid signaling regulates murine bronchial tubule formation. Mech Dev. 2003 Jun; 120(6):691-700. PMID: 12834868.
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    196. Rossant J. Targeting mammalian genes--rats join in and mice move ahead. Nat Biotechnol. 2003 Jun; 21(6):625-7. PMID: 12776146.
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    197. Brivanlou AH, Gage FH, Jaenisch R, Jessell T, Melton D, Rossant J. Stem cells. Setting standards for human embryonic stem cells. Science. 2003 May 09; 300(5621):913-6. PMID: 12738841.
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    198. Trokovic R, Trokovic N, Hernesniemi S, Pirvola U, Vogt Weisenhorn DM, Rossant J, McMahon AP, Wurst W, Partanen J. FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals. EMBO J. 2003 Apr 15; 22(8):1811-23. PMID: 12682014; PMCID: PMC154461.
    199. Kunath T, Gish G, Lickert H, Jones N, Pawson T, Rossant J. Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype. Nat Biotechnol. 2003 May; 21(5):559-61. PMID: 12679785.
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    200. Rossant J, Scherer SW. The mouse genome sequence--the end of the tail, or just the beginning? Genome Biol. 2003; 4(4):109. PMID: 12702199; PMCID: PMC154569.
    201. Hébert JM, Lin M, Partanen J, Rossant J, McConnell SK. FGF signaling through FGFR1 is required for olfactory bulb morphogenesis. Development. 2003 Mar; 130(6):1101-11. PMID: 12571102.
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    202. Motoike T, Markham DW, Rossant J, Sato TN. Evidence for novel fate of Flk1+ progenitor: contribution to muscle lineage. Genesis. 2003 Mar; 35(3):153-9. PMID: 12640619.
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    203. Kislinger T, Rahman K, Radulovic D, Cox B, Rossant J, Emili A. PRISM, a generic large scale proteomic investigation strategy for mammals. Mol Cell Proteomics. 2003 Feb; 2(2):96-106. PMID: 12644571.
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    204. Ema M, Faloon P, Zhang WJ, Hirashima M, Reid T, Stanford WL, Orkin S, Choi K, Rossant J. Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. Genes Dev. 2003 Feb 01; 17(3):380-93. PMID: 12569129; PMCID: PMC195986.
    205. Tanaka TS, Kunath T, Kimber WL, Jaradat SA, Stagg CA, Usuda M, Yokota T, Niwa H, Rossant J, Ko MS. Gene expression profiling of embryo-derived stem cells reveals candidate genes associated with pluripotency and lineage specificity. Genome Res. 2002 Dec; 12(12):1921-8. PMID: 12466296; PMCID: PMC187571.
    206. Wigle DA, Jurisica I, Radulovich N, Pintilie M, Rossant J, Liu N, Lu C, Woodgett J, Seiden I, Johnston M, Keshavjee S, Darling G, Winton T, Breitkreutz BJ, Jorgenson P, Tyers M, Shepherd FA, Tsao MS. Molecular profiling of non-small cell lung cancer and correlation with disease-free survival. Cancer Res. 2002 Jun 01; 62(11):3005-8. PMID: 12036904.
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    207. Bayle JH, Randazzo F, Johnen G, Kaufman S, Nagy A, Rossant J, Crabtree GR. Hyperphenylalaninemia and impaired glucose tolerance in mice lacking the bifunctional DCoH gene. J Biol Chem. 2002 Aug 09; 277(32):28884-91. PMID: 12011081.
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    208. Rossant J, Howard L. Signaling pathways in vascular development. Annu Rev Cell Dev Biol. 2002; 18:541-73. PMID: 12142271.
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    209. Rossant J. A monoclonal mouse? Nature. 2002 Feb 28; 415(6875):967-9. PMID: 11875546.
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    210. Goetinck PF, Papaionnou G, Rossant J, Tam P, Anderson K, Hastie N, Soriano P, Bullock S, Rodriguez T, Dunwoodie S, Wilson V, Thomas P, Conlon F, Pevney L. Remembering Rosa Beddington--a tribute from her friends and colleagues. Dev Dyn. 2002 Jan; 223(1):3-11. PMID: 11803565.
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    211. Rossant J, McKerlie C. Mouse-based phenogenomics for modelling human disease. Trends Mol Med. 2001 Nov; 7(11):502-7. PMID: 11689335.
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    212. Matsumoto K, Yoshitomi H, Rossant J, Zaret KS. Liver organogenesis promoted by endothelial cells prior to vascular function. Science. 2001 Oct 19; 294(5542):559-63. PMID: 11577199.
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    213. Wigle DA, Rossant J, Jurisica I. Mining mouse microarray data. Genome Biol. 2001; 2(7):REVIEWS1019. PMID: 11516341; PMCID: PMC139418.
    214. Ciruna B, Rossant J. FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev Cell. 2001 Jul; 1(1):37-49. PMID: 11703922.
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    215. Rossant J, Cross JC. Placental development: lessons from mouse mutants. Nat Rev Genet. 2001 Jul; 2(7):538-48. PMID: 11433360.
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    216. Hoodless PA, Pye M, Chazaud C, Labbé E, Attisano L, Rossant J, Wrana JL. FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Genes Dev. 2001 May 15; 15(10):1257-71. PMID: 11358869; PMCID: PMC313796.
    217. Uyttendaele H, Ho J, Rossant J, Kitajewski J. Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5643-8. PMID: 11344305; PMCID: PMC33266.
    218. Tremblay GB, Kunath T, Bergeron D, Lapointe L, Champigny C, Bader JA, Rossant J, Giguère V. Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta. Genes Dev. 2001 Apr 01; 15(7):833-8. PMID: 11297507; PMCID: PMC312665.
    219. Tropepe V, Hitoshi S, Sirard C, Mak TW, Rossant J, van der Kooy D. Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron. 2001 Apr; 30(1):65-78. PMID: 11343645.
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    220. Nadeau JH, Balling R, Barsh G, Beier D, Brown SD, Bucan M, Camper S, Carlson G, Copeland N, Eppig J, Fletcher C, Frankel WN, Ganten D, Goldowitz D, Goodnow C, Guenet JL, Hicks G, Hrabe de Angelis M, Jackson I, Jacob HJ, Jenkins N, Johnson D, Justice M, Kay S, Kingsley D, Lehrach H, Magnuson T, Meisler M, Poustka A, Rinchik EM, Rossant J, Russell LB, Schimenti J, Shiroishi T, Skarnes WC, Soriano P, Stanford W, Takahashi JS, Wurst W, Zimmer A. Sequence interpretation. Functional annotation of mouse genome sequences. Science. 2001 Feb 16; 291(5507):1251-5. PMID: 11233449.
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    221. Sakai Y, Meno C, Fujii H, Nishino J, Shiratori H, Saijoh Y, Rossant J, Hamada H. The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo. Genes Dev. 2001 Jan 15; 15(2):213-25. PMID: 11157777; PMCID: PMC312617.
    222. Jin O, Harpal K, Ang SL, Rossant J. Otx2 and HNF3beta genetically interact in anterior patterning. Int J Dev Biol. 2001; 45(1):357-65. PMID: 11291866.
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    223. Nagy A, Rossant J. Chimaeras and mosaics for dissecting complex mutant phenotypes. Int J Dev Biol. 2001; 45(3):577-82. PMID: 11417901.
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    224. Rossant J. Stem cells from the Mammalian blastocyst. Stem Cells. 2001; 19(6):477-82. PMID: 11713338.
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    225. Rossant J. Stem cells in the mammalian blastocyst. Harvey Lect. 2001-2002; 97:17-40. PMID: 14562515.
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    226. Bates CM, Kharzai S, Erwin T, Rossant J, Parada LF. Role of N-myc in the developing mouse kidney. Dev Biol. 2000 Jun 15; 222(2):317-25. PMID: 10837121.
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    227. Clarke G, Goldberg AF, Vidgen D, Collins L, Ploder L, Schwarz L, Molday LL, Rossant J, Szél A, Molday RS, Birch DG, McInnes RR. Rom-1 is required for rod photoreceptor viability and the regulation of disk morphogenesis. Nat Genet. 2000 May; 25(1):67-73. PMID: 10802659.
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    228. Saxton TM, Ciruna BG, Holmyard D, Kulkarni S, Harpal K, Rossant J, Pawson T. The SH2 tyrosine phosphatase shp2 is required for mammalian limb development. Nat Genet. 2000 Apr; 24(4):420-3. PMID: 10742110.
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    229. Bachiller D, Klingensmith J, Kemp C, Belo JA, Anderson RM, May SR, McMahon JA, McMahon AP, Harland RM, Rossant J, De Robertis EM. The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature. 2000 Feb 10; 403(6770):658-61. PMID: 10688202.
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    230. Klingensmith J, Ang SL, Bachiller D, Rossant J. Neural induction and patterning in the mouse in the absence of the node and its derivatives. Dev Biol. 1999 Dec 15; 216(2):535-49. PMID: 10642791.
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    231. Quaggin SE, Schwartz L, Cui S, Igarashi P, Deimling J, Post M, Rossant J. The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis. Development. 1999 Dec; 126(24):5771-83. PMID: 10572052.
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    232. Puri MC, Partanen J, Rossant J, Bernstein A. Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development. Development. 1999 Oct; 126(20):4569-80. PMID: 10498691.
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    233. Tanaka M, Puchyr M, Gertsenstein M, Harpal K, Jaenisch R, Rossant J, Nagy A. Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation. Mech Dev. 1999 Sep; 87(1-2):129-42. PMID: 10495277.
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    234. Miquerol L, Gertsenstein M, Harpal K, Rossant J, Nagy A. Multiple developmental roles of VEGF suggested by a LacZ-tagged allele. Dev Biol. 1999 Aug 15; 212(2):307-22. PMID: 10433823.
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    235. Barrantes IB, Elia AJ, Wünsch K, Hrabe de Angelis MH, Mak TW, Rossant J, Conlon RA, Gossler A, de la Pompa JL. Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse. Curr Biol. 1999 May 06; 9(9):470-80. PMID: 10330372.
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    236. Pearce JJ, Penny G, Rossant J. A mouse cerberus/Dan-related gene family. Dev Biol. 1999 May 01; 209(1):98-110. PMID: 10208746.
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    237. Tropepe V, Sibilia M, Ciruna BG, Rossant J, Wagner EF, van der Kooy D. Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon. Dev Biol. 1999 Apr 01; 208(1):166-88. PMID: 10075850.
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    238. Ciruna BG, Rossant J. Expression of the T-box gene Eomesodermin during early mouse development. Mech Dev. 1999 Mar; 81(1-2):199-203. PMID: 10330500.
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    239. Rossant J, McMahon A. "Cre"-ating mouse mutants-a meeting review on conditional mouse genetics. Genes Dev. 1999 Jan 15; 13(2):142-5. PMID: 9925637.
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    240. Janatpour MJ, Utset MF, Cross JC, Rossant J, Dong J, Israel MA, Fisher SJ. A repertoire of differentially expressed transcription factors that offers insight into mechanisms of human cytotrophoblast differentiation. Dev Genet. 1999; 25(2):146-57. PMID: 10440849.
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    241. Rossant J, Nagy A. In search of the tabula rasa of human cells. Nat Biotechnol. 1999 Jan; 17(1):23-4. PMID: 9920262.
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    242. Tanaka S, Kunath T, Hadjantonakis AK, Nagy A, Rossant J. Promotion of trophoblast stem cell proliferation by FGF4. Science. 1998 Dec 11; 282(5396):2072-5. PMID: 9851926.
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    243. Rossant J, Spence A. Chimeras and mosaics in mouse mutant analysis. Trends Genet. 1998 Sep; 14(9):358-63. PMID: 9769731.
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    244. Partanen J, Schwartz L, Rossant J. Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev. 1998 Aug 01; 12(15):2332-44. PMID: 9694798; PMCID: PMC317047.
    245. Dufort D, Schwartz L, Harpal K, Rossant J. The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis. Development. 1998 Aug; 125(16):3015-25. PMID: 9671576.
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    246. Duncan SA, Navas MA, Dufort D, Rossant J, Stoffel M. Regulation of a transcription factor network required for differentiation and metabolism. Science. 1998 Jul 31; 281(5377):692-5. PMID: 9685261.
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    247. Ding Q, Motoyama J, Gasca S, Mo R, Sasaki H, Rossant J, Hui CC. Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development. 1998 Jul; 125(14):2533-43. PMID: 9636069.
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    248. Nagy A, Moens C, Ivanyi E, Pawling J, Gertsenstein M, Hadjantonakis AK, Pirity M, Rossant J. Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles. Curr Biol. 1998 May 21; 8(11):661-4. PMID: 9635194.
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    249. Rossant J, Guillemot F, Tanaka M, Latham K, Gertenstein M, Nagy A. Mash2 is expressed in oogenesis and preimplantation development but is not required for blastocyst formation. Mech Dev. 1998 May; 73(2):183-91. PMID: 9622625.
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    250. Sirard C, de la Pompa JL, Elia A, Itie A, Mirtsos C, Cheung A, Hahn S, Wakeham A, Schwartz L, Kern SE, Rossant J, Mak TW. The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev. 1998 Jan 01; 12(1):107-19. PMID: 9420335; PMCID: PMC316400.
    251. Tanaka M, Gertsenstein M, Rossant J, Nagy A. Mash2 acts cell autonomously in mouse spongiotrophoblast development. Dev Biol. 1997 Oct 01; 190(1):55-65. PMID: 9331331.
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    252. Zhang F, Pöpperl H, Morrison A, Kovàcs EN, Prideaux V, Schwarz L, Krumlauf R, Rossant J, Featherstone MS. Elements both 5' and 3' to the murine Hoxd4 gene establish anterior borders of expression in mesoderm and neurectoderm. Mech Dev. 1997 Sep; 67(1):49-58. PMID: 9347914.
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    253. Luo J, Sladek R, Bader JA, Matthyssen A, Rossant J, Giguère V. Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta. Nature. 1997 Aug 21; 388(6644):778-82. PMID: 9285590.
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    254. De Sousa PA, Juneja SC, Caveney S, Houghton FD, Davies TC, Reaume AG, Rossant J, Kidder GM. Normal development of preimplantation mouse embryos deficient in gap junctional coupling. J Cell Sci. 1997 Aug; 110 ( Pt 15):1751-8. PMID: 9264462.
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    255. Ciruna BG, Schwartz L, Harpal K, Yamaguchi TP, Rossant J. Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak. Development. 1997 Jul; 124(14):2829-41. PMID: 9226454.
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    256. Shalaby F, Ho J, Stanford WL, Fischer KD, Schuh AC, Schwartz L, Bernstein A, Rossant J. A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis. Cell. 1997 Jun 13; 89(6):981-90. PMID: 9200616.
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    257. Rossant J, Papaioannou VE, Lawson K, Fraser S, Copp A. NIEHS/EPA Workshops. Cell lineages. Reprod Toxicol. 1997 Mar-Jun; 11(2-3):317-9. PMID: 9100306.
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    258. de la Pompa JL, Wakeham A, Correia KM, Samper E, Brown S, Aguilera RJ, Nakano T, Honjo T, Mak TW, Rossant J, Conlon RA. Conservation of the Notch signalling pathway in mammalian neurogenesis. Development. 1997 Mar; 124(6):1139-48. PMID: 9102301.
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    259. Rossant J, Ciruna B, Partanen J. FGF signaling in mouse gastrulation and anteroposterior patterning. Cold Spring Harb Symp Quant Biol. 1997; 62:127-33. PMID: 9598344.
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    260. Partanen J, Puri MC, Schwartz L, Fischer KD, Bernstein A, Rossant J. Cell autonomous functions of the receptor tyrosine kinase TIE in a late phase of angiogenic capillary growth and endothelial cell survival during murine development. Development. 1996 Oct; 122(10):3013-21. PMID: 8898215.
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    261. Fong GH, Klingensmith J, Wood CR, Rossant J, Breitman ML. Regulation of flt-1 expression during mouse embryogenesis suggests a role in the establishment of vascular endothelium. Dev Dyn. 1996 Sep; 207(1):1-10. PMID: 8875071.
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    262. Hakem R, de la Pompa JL, Sirard C, Mo R, Woo M, Hakem A, Wakeham A, Potter J, Reitmair A, Billia F, Firpo E, Hui CC, Roberts J, Rossant J, Mak TW. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell. 1996 Jun 28; 85(7):1009-23. PMID: 8674108.
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    263. Nagy A, Rossant J. Targeted mutagenesis: analysis of phenotype without germ line transmission. J Clin Invest. 1996 Mar 15; 97(6):1360-5. PMID: 8617866; PMCID: PMC507193.
    264. Rossant J. Mouse mutants and cardiac development: new molecular insights into cardiogenesis. Circ Res. 1996 Mar; 78(3):349-53. PMID: 8593692.
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    265. Ang SL, Jin O, Rhinn M, Daigle N, Stevenson L, Rossant J. A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain. Development. 1996 Jan; 122(1):243-52. PMID: 8565836.
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    266. Puri MC, Rossant J, Alitalo K, Bernstein A, Partanen J. The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells. EMBO J. 1995 Dec 01; 14(23):5884-91. PMID: 8846781; PMCID: PMC394706.
    267. Calzonetti T, Stevenson L, Rossant J. A novel regulatory region is required for trophoblast-specific transcription in transgenic mice. Dev Biol. 1995 Oct; 171(2):615-26. PMID: 7556941.
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    268. Luo J, Pasceri P, Conlon RA, Rossant J, Giguère V. Mice lacking all isoforms of retinoic acid receptor beta develop normally and are susceptible to the teratogenic effects of retinoic acid. Mech Dev. 1995 Sep; 53(1):61-71. PMID: 8555112.
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    269. Yamaguchi TP, Rossant J. Fibroblast growth factors in mammalian development. Curr Opin Genet Dev. 1995 Aug; 5(4):485-91. PMID: 7580141.
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    270. Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitman ML, Schuh AC. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature. 1995 Jul 06; 376(6535):62-6. PMID: 7596435.
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    271. Fong GH, Rossant J, Gertsenstein M, Breitman ML. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature. 1995 Jul 06; 376(6535):66-70. PMID: 7596436.
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    272. Brown A, Bernier G, Mathieu M, Rossant J, Kothary R. The mouse dystonia musculorum gene is a neural isoform of bullous pemphigoid antigen 1. Nat Genet. 1995 Jul; 10(3):301-6. PMID: 7670468.
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    273. Rossant J, Nagy A. Genome engineering: the new mouse genetics. Nat Med. 1995 Jun; 1(6):592-4. PMID: 7585128.
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    274. Conlon RA, Reaume AG, Rossant J. Notch1 is required for the coordinate segmentation of somites. Development. 1995 May; 121(5):1533-45. PMID: 7789282.
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    275. Reaume AG, de Sousa PA, Kulkarni S, Langille BL, Zhu D, Davies TC, Juneja SC, Kidder GM, Rossant J. Cardiac malformation in neonatal mice lacking connexin43. Science. 1995 Mar 24; 267(5205):1831-4. PMID: 7892609.
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    276. Fawcett D, Pasceri P, Fraser R, Colbert M, Rossant J, Giguère V. Postaxial polydactyly in forelimbs of CRABP-II mutant mice. Development. 1995 Mar; 121(3):671-9. PMID: 7720575.
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    277. Guillemot F, Caspary T, Tilghman SM, Copeland NG, Gilbert DJ, Jenkins NA, Anderson DJ, Joyner AL, Rossant J, Nagy A. Genomic imprinting of Mash2, a mouse gene required for trophoblast development. Nat Genet. 1995 Mar; 9(3):235-42. PMID: 7773285.
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    278. Chen ZQ, Lefebvre D, Bai XH, Reaume A, Rossant J, Lye SJ. Identification of two regulatory elements within the promoter region of the mouse connexin 43 gene. J Biol Chem. 1995 Feb 24; 270(8):3863-8. PMID: 7876131.
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    279. Wurst W, Rossant J, Prideaux V, Kownacka M, Joyner A, Hill DP, Guillemot F, Gasca S, Cado D, Auerbach A, et al. A large-scale gene-trap screen for insertional mutations in developmentally regulated genes in mice. Genetics. 1995 Feb; 139(2):889-99. PMID: 7713439; PMCID: PMC1206388.
    280. Gasca S, Hill DP, Klingensmith J, Rossant J. Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo. Dev Genet. 1995; 17(2):141-54. PMID: 7586755.
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    281. Yamaguchi TP, Harpal K, Henkemeyer M, Rossant J. fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes Dev. 1994 Dec 15; 8(24):3032-44. PMID: 8001822.
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    282. Ang SL, Conlon RA, Jin O, Rossant J. Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants. Development. 1994 Oct; 120(10):2979-89. PMID: 7607086.
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    283. Guillemot F, Nagy A, Auerbach A, Rossant J, Joyner AL. Essential role of Mash-2 in extraembryonic development. Nature. 1994 Sep 22; 371(6495):333-6. PMID: 8090202.
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    284. Ang SL, Rossant J. HNF-3 beta is essential for node and notochord formation in mouse development. Cell. 1994 Aug 26; 78(4):561-74. PMID: 8069909.
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    285. Meyer BJ, Rossant J. Pattern formation and developmental mechanisms. Curr Opin Genet Dev. 1994 Aug; 4(4):499-501. PMID: 7950315.
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    286. Brown A, Lemieux N, Rossant J, Kothary R. Human homolog of a mouse sequence from the dystonia musculorum locus is on chromosome 6p12. Mamm Genome. 1994 Jul; 5(7):434-7. PMID: 7919656.
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    287. Brown A, Copeland NG, Gilbert DJ, Jenkins NA, Rossant J, Kothary R. The genomic structure of an insertional mutation in the dystonia musculorum locus. Genomics. 1994 Apr; 20(3):371-6. PMID: 8034309.
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    288. Randazzo FM, Khavari P, Crabtree G, Tamkun J, Rossant J. brg1: a putative murine homologue of the Drosophila brahma gene, a homeotic gene regulator. Dev Biol. 1994 Jan; 161(1):229-42. PMID: 7904967.
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    289. Ang SL, Wierda A, Wong D, Stevens KA, Cascio S, Rossant J, Zaret KS. The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development. 1993 Dec; 119(4):1301-15. PMID: 8306889.
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    290. Moens CB, Stanton BR, Parada LF, Rossant J. Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus. Development. 1993 Oct; 119(2):485-99. PMID: 8287798.
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    291. Nagy A, Rossant J, Nagy R, Abramow-Newerly W, Roder JC. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci U S A. 1993 Sep 15; 90(18):8424-8. PMID: 8378314; PMCID: PMC47369.
    292. Wood SA, Allen ND, Rossant J, Auerbach A, Nagy A. Non-injection methods for the production of embryonic stem cell-embryo chimaeras. Nature. 1993 Sep 02; 365(6441):87-9. PMID: 8361547.
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    293. Yamaguchi TP, Dumont DJ, Conlon RA, Breitman ML, Rossant J. flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors. Development. 1993 Jun; 118(2):489-98. PMID: 8223275.
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    294. Ang SL, Rossant J. Anterior mesendoderm induces mouse Engrailed genes in explant cultures. Development. 1993 May; 118(1):139-49. PMID: 8375331.
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    295. Carney EW, Prideaux V, Lye SJ, Rossant J. Progressive expression of trophoblast-specific genes during formation of mouse trophoblast giant cells in vitro. Mol Reprod Dev. 1993 Apr; 34(4):357-68. PMID: 8471259.
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    296. Rossant J, Bernelot-Moens C, Nagy A. Genome manipulation in embryonic stem cells. Philos Trans R Soc Lond B Biol Sci. 1993 Feb 27; 339(1288):207-15. PMID: 8097050.
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    297. Rossant J. Immortal germ cells? Curr Biol. 1993 Jan; 3(1):47-9. PMID: 15335881.
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    298. Reaume AG, Conlon RA, Zirngibl R, Yamaguchi TP, Rossant J. Expression analysis of a Notch homologue in the mouse embryo. Dev Biol. 1992 Dec; 154(2):377-87. PMID: 1426644.
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    299. Soininen R, Schoor M, Henseling U, Tepe C, Kisters-Woike B, Rossant J, Gossler A. The mouse Enhancer trap locus 1 (Etl-1): a novel mammalian gene related to Drosophila and yeast transcriptional regulator genes. Mech Dev. 1992 Nov; 39(1-2):111-23. PMID: 1489724.
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    300. Conlon RA, Rossant J. Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo. Development. 1992 Oct; 116(2):357-68. PMID: 1363087.
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    301. Dumont DJ, Yamaguchi TP, Conlon RA, Rossant J, Breitman ML. tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors. Oncogene. 1992 Aug; 7(8):1471-80. PMID: 1630810.
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    302. Yamaguchi TP, Conlon RA, Rossant J. Expression of the fibroblast growth factor receptor FGFR-1/flg during gastrulation and segmentation in the mouse embryo. Dev Biol. 1992 Jul; 152(1):75-88. PMID: 1321062.
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    303. Moens CB, Auerbach AB, Conlon RA, Joyner AL, Rossant J. A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung. Genes Dev. 1992 May; 6(5):691-704. PMID: 1577267.
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    304. Nadeau JH, Compton JG, Giguère V, Rossant J, Varmuza S. Close linkage of retinoic acid receptor genes with homeobox- and keratin-encoding genes on paralogous segments of mouse chromosomes 11 and 15. Mamm Genome. 1992; 3(4):202-8. PMID: 1377062.
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    305. Rossant J, Hopkins N. Of fin and fur: mutational analysis of vertebrate embryonic development. Genes Dev. 1992 Jan; 6(1):1-13. PMID: 1730405.
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    306. Motro B, van der Kooy D, Rossant J, Reith A, Bernstein A. Contiguous patterns of c-kit and steel expression: analysis of mutations at the W and Sl loci. Development. 1991 Dec; 113(4):1207-21. PMID: 1811937.
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    307. Forrester LM, Bernstein A, Rossant J, Nagy A. Long-term reconstitution of the mouse hematopoietic system by embryonic stem cell-derived fetal liver. Proc Natl Acad Sci U S A. 1991 Sep 01; 88(17):7514-7. PMID: 1881890; PMCID: PMC52331.
    308. Rossant J, Zirngibl R, Cado D, Shago M, Giguère V. Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis. Genes Dev. 1991 Aug; 5(8):1333-44. PMID: 1907940.
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    309. Rossant J. Gene disruption in mammals. Curr Opin Genet Dev. 1991 Aug; 1(2):236-40. PMID: 1688005.
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    310. Joyner AL, Herrup K, Auerbach BA, Davis CA, Rossant J. Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. Science. 1991 Mar 08; 251(4998):1239-43. PMID: 1672471.
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    311. Nagy A, Gócza E, Diaz EM, Prideaux VR, Iványi E, Markkula M, Rossant J. Embryonic stem cells alone are able to support fetal development in the mouse. Development. 1990 Nov; 110(3):815-21. PMID: 2088722.
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    312. Fishell G, Rossant J, van der Kooy D. Neuronal lineages in chimeric mouse forebrain are segregated between compartments and in the rostrocaudal and radial planes. Dev Biol. 1990 Sep; 141(1):70-83. PMID: 2167859.
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    313. Greer P, Maltby V, Rossant J, Bernstein A, Pawson T. Myeloid expression of the human c-fps/fes proto-oncogene in transgenic mice. Mol Cell Biol. 1990 Jun; 10(6):2521-7. PMID: 2188092; PMCID: PMC360609.
    314. Giguère V, Shago M, Zirngibl R, Tate P, Rossant J, Varmuza S. Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo. Mol Cell Biol. 1990 May; 10(5):2335-40. PMID: 2157970; PMCID: PMC360581.
    315. Rossant J. Manipulating the mouse genome: implications for neurobiology. Neuron. 1990 Mar; 4(3):323-34. PMID: 2180452.
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    316. Yee SP, Mock D, Greer P, Maltby V, Rossant J, Bernstein A, Pawson T. Lymphoid and mesenchymal tumors in transgenic mice expressing the v-fps protein-tyrosine kinase. Mol Cell Biol. 1989 Dec; 9(12):5491-9. PMID: 2555699; PMCID: PMC363719.
    317. Lavigueur A, Maltby V, Mock D, Rossant J, Pawson T, Bernstein A. High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol Cell Biol. 1989 Sep; 9(9):3982-91. PMID: 2476668; PMCID: PMC362460.
    318. Rossant J, Joyner AL. Towards a molecular-genetic analysis of mammalian development. Trends Genet. 1989 Aug; 5(8):277-83. PMID: 2686118.
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    319. Yee SP, Mock D, Maltby V, Silver M, Rossant J, Bernstein A, Pawson T. Cardiac and neurological abnormalities in v-fps transgenic mice. Proc Natl Acad Sci U S A. 1989 Aug; 86(15):5873-7. PMID: 2788278; PMCID: PMC297733.
    320. Regenstreif LJ, Rossant J. Expression of the c-fms proto-oncogene and of the cytokine, CSF-1, during mouse embryogenesis. Dev Biol. 1989 May; 133(1):284-94. PMID: 2523324.
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    321. Gossler A, Joyner AL, Rossant J, Skarnes WC. Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. Science. 1989 Apr 28; 244(4903):463-5. PMID: 2497519.
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    322. Kothary R, Clapoff S, Darling S, Perry MD, Moran LA, Rossant J. Inducible expression of an hsp68-lacZ hybrid gene in transgenic mice. Development. 1989 Apr; 105(4):707-14. PMID: 2557196.
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    323. Joyner AL, Skarnes WC, Rossant J. Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells. Nature. 1989 Mar 09; 338(6211):153-6. PMID: 2563902.
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    324. Rossant J. Transgenic animals: techniques. Genome. 1989; 31(2):1112-3. PMID: 2632345.
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    325. Lescisin KR, Varmuza S, Rossant J. Isolation and characterization of a novel trophoblast-specific cDNA in the mouse. Genes Dev. 1988 Dec; 2(12A):1639-46. PMID: 3215514.
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    326. Kothary R, Clapoff S, Brown A, Campbell R, Peterson A, Rossant J. A transgene containing lacZ inserted into the dystonia locus is expressed in neural tube. Nature. 1988 Sep 29; 335(6189):435-7. PMID: 3138544.
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    327. Clarke HJ, Varmuza S, Prideaux VR, Rossant J. The development potential of parthenogenetically derived cells in chimeric mouse embryos: implications for action of imprinted genes. Development. 1988 Sep; 104(1):175-82. PMID: 3253058.
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    328. Clarke HJ, Rossant J, Masui Y. Suppression of chromosome condensation during meiotic maturation induces parthenogenetic development of mouse oocytes. Development. 1988 Sep; 104(1):97-103. PMID: 3253063.
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    329. Davis CA, Noble-Topham SE, Rossant J, Joyner AL. Expression of the homeo box-containing gene En-2 delineates a specific region of the developing mouse brain. Genes Dev. 1988 Mar; 2(3):361-71. PMID: 2454212.
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    330. Burgoyne PS, Buehr M, Koopman P, Rossant J, McLaren A. Cell-autonomous action of the testis-determining gene: Sertoli cells are exclusively XY in XX----XY chimaeric mouse testes. Development. 1988 Feb; 102(2):443-50. PMID: 3166423.
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    331. Varmuza S, Prideaux V, Kothary R, Rossant J. Polytene chromosomes in mouse trophoblast giant cells. Development. 1988 Jan; 102(1):127-34. PMID: 3166422.
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    332. Breitman ML, Clapoff S, Rossant J, Tsui LC, Glode LM, Maxwell IH, Bernstein A. Genetic ablation: targeted expression of a toxin gene causes microphthalmia in transgenic mice. Science. 1987 Dec 11; 238(4833):1563-5. PMID: 3685993.
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    333. Sanford JP, Clark HJ, Chapman VM, Rossant J. Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse. Genes Dev. 1987 Dec; 1(10):1039-46. PMID: 3428592.
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    334. Sapienza C, Peterson AC, Rossant J, Balling R. Degree of methylation of transgenes is dependent on gamete of origin. Nature. 1987 Jul 16-22; 328(6127):251-4. PMID: 3600806.
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    335. Kothary R, Perry MD, Moran LA, Rossant J. Cell-lineage-specific expression of the mouse hsp68 gene during embryogenesis. Dev Biol. 1987 Jun; 121(2):342-8. PMID: 3582732.
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    336. Croy BA, Rossant J. Mouse embryonic cells become susceptible to CTL lysis after midgestation. Cell Immunol. 1987 Feb; 104(2):355-65. PMID: 3493080.
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    337. Goring DR, Rossant J, Clapoff S, Breitman ML, Tsui LC. In situ detection of beta-galactosidase in lenses of transgenic mice with a gamma-crystallin/lacZ gene. Science. 1987 Jan 23; 235(4787):456-8. PMID: 3099390.
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    338. Rossant J. Cell lineage analysis in mammalian embryogenesis. Curr Top Dev Biol. 1987; 23:115-46. PMID: 3330501.
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    339. Waters BK, Rossant J. The effect of retinoic acid pretreatment on the ability of murine embryonal carcinoma and inner cell mass cells to participate in chimaera development. J Embryol Exp Morphol. 1986 Nov; 98:99-110. PMID: 3655654.
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    340. Rossant J, Sanford JP, Chapman VM, Andrews GK. Undermethylation of structural gene sequences in extraembryonic lineages of the mouse. Dev Biol. 1986 Oct; 117(2):567-73. PMID: 2428685.
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    341. Clark DA, Croy BA, Rossant J, Chaouat G. Immune presensitization and local intrauterine defences as determinants of success or failure of murine interspecies pregnancies. J Reprod Fertil. 1986 Jul; 77(2):633-43. PMID: 3488398.
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    342. Deamant FD, Vijh M, Rossant J, Iannaccone PM. In situ identification of host derived infiltrating cells in chemically induced fibrosarcomas of interspecific chimeric mice. Int J Cancer. 1986 Feb 15; 37(2):283-6. PMID: 3943924.
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    343. Rossant J, Vijh KM, Grossi CE, Cooper MD. Clonal origin of haematopoietic colonies in the postnatal mouse liver. Nature. 1986 Feb 6-12; 319(6053):507-11. PMID: 3945334.
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    344. Bernstein A, Dick JE, Huszar D, Robson I, Rossant J, Magli C, Estrov Z, Freedman M, Phillips RA. Genetic engineering of mouse and human stem cells. Cold Spring Harb Symp Quant Biol. 1986; 51 Pt 2:1083-91. PMID: 3472753.
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    345. Rossant J. Interspecific cell markers and lineage in mammals. Philos Trans R Soc Lond B Biol Sci. 1985 Dec 17; 312(1153):91-100. PMID: 2869531.
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    346. Huszar D, Balling R, Kothary R, Magli MC, Hozumi N, Rossant J, Bernstein A. Insertion of a bacterial gene into the mouse germ line using an infectious retrovirus vector. Proc Natl Acad Sci U S A. 1985 Dec; 82(24):8587-91. PMID: 2417225; PMCID: PMC390962.
    347. Gambel P, Croy BA, Moore WD, Hunziker RD, Wegmann TG, Rossant J. Characterization of immune effector cells present in early murine decidua. Cell Immunol. 1985 Jul; 93(2):303-14. PMID: 3159483.
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    348. Croy BA, Gambel P, Rossant J, Wegmann TG. Characterization of murine decidual natural killer (NK) cells and their relevance to the success of pregnancy. Cell Immunol. 1985 Jul; 93(2):315-26. PMID: 4005958.
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    349. Croy BA, Rossant J, Clark DA. Effects of alterations in the immunocompetent status of Mus musculus females on the survival of transferred Mus caroli embryos. J Reprod Fertil. 1985 Jul; 74(2):479-89. PMID: 3876431.
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    350. Rossant J, Croy BA. Genetic identification of tissue of origin of cellular populations within the mouse placenta. J Embryol Exp Morphol. 1985 Apr; 86:177-89. PMID: 4031739.
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    351. Gambel P, Rossant J, Hunziker RD, Wegmann TG. Origin of decidual cells in murine pregnancy and pseudopregnancy. Transplantation. 1985 Apr; 39(4):443-5. PMID: 3984021.
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    352. Rossant J, Papaioannou VE. Outgrowth of embryonal carcinoma cells from injected blastocysts in vitro correlates with abnormal chimera development in vivo. Exp Cell Res. 1985 Jan; 156(1):213-20. PMID: 3994789.
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    353. Rossant J, Papaioannou VE. The relationship between embryonic, embryonal carcinoma and embryo-derived stem cells. Cell Differ. 1984 Dec; 15(2-4):155-61. PMID: 6399008.
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    354. Papaioannou VE, Waters BK, Rossant J. Interactions between diploid embryonal carcinoma cells and early embryonic cells. Cell Differ. 1984 Dec; 15(2-4):175-9. PMID: 6535642.
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    355. Rossant J. The mechanism of survival of the fetal allograft. Ann Immunol (Paris). 1984 Nov-Dec; 135D(3):312-5. PMID: 6241447.
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    356. Clark DA, Slapsys RM, Croy BA, Rossant J. Immunoregulation of host-versus-graft responses in the uterus. Immunol Today. 1984 Apr; 5(4):111-5. PMID: 25291705.
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    357. Clark DA, Slapsys R, Croy BA, Krcek J, Rossant J. Local active suppression by suppressor cells in the decidua: a review. Am J Reprod Immunol. 1984 Mar; 5(2):78-83. PMID: 6232864.
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    358. Croy BA, Rossant J, Clark DA. Recruitment of cytotoxic cells by ectopic grafts of xenogeneic, but not allogeneic, trophoblast. Transplantation. 1984 Jan; 37(1):84-90. PMID: 6420958.
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    359. Dean WL, Rossant J. Effect of delaying DNA replication on blastocyst formation in the mouse. Differentiation. 1984; 26(2):134-7. PMID: 6428955.
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    360. Chapman V, Forrester L, Sanford J, Hastie N, Rossant J. Cell lineage-specific undermethylation of mouse repetitive DNA. Nature. 1984 Jan 19-25; 307(5948):284-6. PMID: 6694730.
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    361. Rossant J, Croy BA, Clark DA, Chapman VM. Interspecific hybrids and chimeras in mice. J Exp Zool. 1983 Nov; 228(2):223-33. PMID: 6663258.
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    362. Clark DA, Slapsys RM, Croy BA, Rossant J. Suppressor cell activity in uterine decidua correlates with success or failure of murine pregnancies. J Immunol. 1983 Aug; 131(2):540-2. PMID: 6223085.
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    363. Croy BA, Rossant J, Clark DA, Wegmann TG. Nonspecific suppression of in vitro generation of cytotoxic lymphocytes by allogeneic and xenogeneic embryonic tissues. Transplantation. 1983 Jun; 35(6):627-9. PMID: 6603036.
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    364. Rossant J, Chapman VM. Somatic and germline mosaicism in interspecific chimaeras between Mus musculus and Mus caroli. J Embryol Exp Morphol. 1983 Feb; 73:193-205. PMID: 6576092.
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    365. Siracusa LD, Chapman VM, Bennett KL, Hastie ND, Pietras DF, Rossant J. Use of repetitive DNA sequences to distinguish Mus musculus and Mus caroli cells by in situ hybridization. J Embryol Exp Morphol. 1983 Feb; 73:163-78. PMID: 6875456.
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    366. Rossant J, Vijh M, Siracusa LD, Chapman VM. Identification of embryonic cell lineages in histological sections of M. musculus in-equilibrium M. caroli chimaeras. J Embryol Exp Morphol. 1983 Feb; 73:179-91. PMID: 6875458.
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    367. Lewis NE, Rossant J. Mechanism of size regulation in mouse embryo aggregates. J Embryol Exp Morphol. 1982 Dec; 72:169-81. PMID: 7183736.
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    368. Rossant J, Croy BA, Chapman VM, Siracusa L, Clark DA. Interspecific chimeras in mammals: a new experimental system. J Anim Sci. 1982 Nov; 55(5):1241-8. PMID: 6757236.
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    369. Croy BA, Rossant J, Clark DA. Histological and immunological studies of post implantation death of Mus caroli embryos in the Mus musculus uterus. J Reprod Immunol. 1982 Sep; 4(5):277-93. PMID: 7131431.
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    370. Rossant J, McBurney MW. The developmental potential of a euploid male teratocarcinoma cell line after blastocyst injection. J Embryol Exp Morphol. 1982 Aug; 70:99-112. PMID: 7142904.
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    371. Rossant J, Mauro VM, Croy BA. Importance of trophoblast genotype for survival of interspecific murine chimaeras. J Embryol Exp Morphol. 1982 Jun; 69:141-9. PMID: 7119665.
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    372. Rossant J, Vijh KM. In vivo and in vitro development of mouse embryos homozygous for the embryonic lethal velvet coat (Ve) mutation. J Embryol Exp Morphol. 1981 Dec; 66:43-55. PMID: 7338714.
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    373. Rossant J, Tamura-Lis W. Effect of culture conditions on diploid to giant-cell transformation in postimplantation mouse trophoblast. J Embryol Exp Morphol. 1981 Apr; 62:217-27. PMID: 6895086.
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    374. Johnson MH, Rossant J. Molecular studies on cells of the trophectodermal lineage of the postimplantation mouse embryo. J Embryol Exp Morphol. 1981 Feb; 61:103-16. PMID: 6894940.
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    375. Frels WI, Rossant J, Chapman VM. Intrinsic and extrinsic factors affecting the viability of Mus caroli x M. musculus hybrid embryos. J Reprod Fertil. 1980 Jul; 59(2):387-92. PMID: 7431295.
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    376. Rossant J, Vijh KM. Ability of outside cells from preimplantation mouse embryos to form inner cell mass derivatives. Dev Biol. 1980 May; 76(2):475-82. PMID: 6893035.
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    377. Rossant J, Frels WI. Interspecific chimeras in mammals: successful production of live chimeras between Mus musculus and Mus caroli. Science. 1980 Apr 25; 208(4442):419-21. PMID: 7367871.
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    378. Gardner RL, Rossant J. Investigation of the fate of 4-5 day post-coitum mouse inner cell mass cells by blastocyst injection. J Embryol Exp Morphol. 1979 Aug; 52:141-52. PMID: 521746.
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    379. Rossant J, Lis WT. Potential of isolated mouse inner cell masses to form trophectoderm derivatives in vivo. Dev Biol. 1979 May; 70(1):255-61. PMID: 582309.
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    380. Rossant J, Lis WT. The possible dual origin of the ectoderm of the chorion in the mouse embryo. Dev Biol. 1979 May; 70(1):249-54. PMID: 456743.
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    381. Rossant J, Gardner RL, Alexandre HL. Investigation of the potency of cells from the postimplantation mouse embryo by blastocyst injection: a preliminary report. J Embryol Exp Morphol. 1978 Dec; 48:239-47. PMID: 370330.
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    382. Copp AJ, Rossant J. Effect of implantation delay on transfer of rat embryos to mice. J Reprod Fertil. 1978 Jan; 52(1):119-21. PMID: 621685.
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    383. Rossant J. [Crohn's disease]. Infirm Fr. 1977 Oct; (188):9-10. PMID: 243498.
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    384. Rossant J, Ofer L. Properties of extra-embryonic ectoderm isolated from postimplantation mouse embryos. J Embryol Exp Morphol. 1977 Jun; 39:183-94. PMID: 560422.
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    385. Rossant J. Postimplantation development of blastomeres isolated from 4- and 8-cell mouse eggs. J Embryol Exp Morphol. 1976 Oct; 36(2):283-90. PMID: 1033982.
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    386. Rossant J. Investigation of inner cell mass determination by aggregation of isolated rat inner cell masses with mouse morulae. J Embryol Exp Morphol. 1976 Aug; 36(1):163-74. PMID: 989774.
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    387. Tarkowski AK, Rossant J. Haploid mouse blastocysts developed from bisected zygotes. Nature. 1976 Feb 26; 259(5545):663-5. PMID: 1250417.
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    388. Kelly SJ, Rossant J. The effect of short-term labelling in (3H) thymidine on the viability of mouse blastomeres: alone and in combination with unlabelled blastomeres. J Embryol Exp Morphol. 1976 Feb; 35(1):95-106. PMID: 946814.
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    389. Rossant J. Investigation of the determinative state of the mouse inner cell mass. I. Aggregation of isolated inner cell masses with morulae. J Embryol Exp Morphol. 1975 Jul; 33(4):979-90. PMID: 1176884.
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    390. Rossant J. Investigation of the determinative state of the mouse inner cell mass. II. The fate of isolated inner cell masses transferred to the oviduct. J Embryol Exp Morphol. 1975 Jul; 33(4):991-1001. PMID: 1176885.
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