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Julie Forman-Kay

TitleProgram Head & Senior Scientist
InstitutionThe Hospital for Sick Children
DepartmentMolecular Medicine
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Biography 
    Collapse education and training
    Massachusetts Institute of Technology, Cambridge, MassachusettsB.Sc.04/1985Chemistry
    Yale University, New Haven, ConnecticutPhD.04/1990Molecular Biophysics and Biochemistry
    Collapse awards and honors
    2016Fellow of the Royal Society of Canada (FRSC), Royal Society of Canada
    2016 - 2023Canada Research Chair (Tier 1), Government of Canada
    2013 - 2014Zellers Senior Scientist Award
    2012 - 2013CSMB Jeanne Manery Fisher Memorial Lectureship, Canadian Society for Molecular Biosciences
    1999 - 2004Ontario Government Premier’s Research Excellence Award (PREA), Government of Ontario
    2000 - 2005Canadian Institutes of Health Research Scientist Award, Canadian Institutes of Health Research
    1994 - 1999Scholarship Award, Medical Research Council of Canada

    Collapse Overview 
    Collapse overview
    Dr. Julie Deborah Forman-Kay received her B.Sc. specializing in chemistry, from the Massachusetts Institute of Technology in 1985. In 1990, she received her PhD in molecular biophysics & biochemistry from Yale University under the supervision of Dr. Fred Richards.

    Forman-Kay completed her post-doctoral studies at the Laboratory of Chemical Physics at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health in Bethesda, Maryland in 1992. Her supervisors were Marius Clore & Angela Gronenborn. In 1992, she joined The Hospital for Sick Children (SickKids) and the Department of Biochemistry at the University of Toronto.

    The major focus of the Forman-Kay lab is to provide biological insights into how dynamic properties of proteins are related to function and methodological tools to enable better understanding of dynamic and disordered states. Her expertise is in using NMR and other biophysical and computational tools to study dynamic and disordered proteins and their interactions, including characterizing their dynamic complexes that are mediated by multivalent interactions. Approaches for calculating computational representations disordered state ensembles have been developed in her group. A related area of interest is the role of post-translational modification, such as phosphorylation and methylation, in regulating structural and binding properties in disordered states and dynamic complexes.

    The Forman-Kay lab works on a number of projects of specific relevance to cancer and neurobiology. Most recently her lab has started to probe the role phase separation of disordered proteins in RNA processing bodies, a key regulatory process for neurological function. Her group also has a strong interest in CFTR, the cystic fibrosis transmembrane conductance regulator, particularly its cytoplasmic domains including the disordered regulatory R region. Her work is highly collaborative, with contributions to the fields of intrinsically disordered proteins, protein interaction domains, and CFTR structure, dynamics and interactions.


    Collapse Research 
    Collapse research activities and funding
    FORMAN13XX0     (Julie Forman-Kay)Sep 1, 2013 - Aug 31, 2018
    CFFT
    NMR Studies of CFTR NBD and ICD Structure, Dynamics and Interactions

         (Julie Forman-Kay)Apr 1, 2015 - Mar 31, 2020
    CFI - Innovation Fund
    Dynamic complexes and large-scale assemblies in neurobiology and disease
    Role Description: Management and biophysical equipment for SickKids Research Institute's Structural & Biophysical Core Facility

    2R01DK051610-20A1     (Kevin Strange)Jul 8, 2015 - Jun 30, 2018
    NIH - Research Project Grant (R0l)
    Mechanisms of phosphorylation mediated intraprotein signaling in a CLC CI channel
    Role: Co-Principal Investigator

         (Julie Forman-Kay)Jan 31, 2016 - Feb 1, 2023
    CIHR - Canada Research Chair (Tier 1)
    Intrinsically Disordered Proteins

         (Julie Forman-Kay)Jan 31, 2016 - Feb 1, 2023
    CIHR - Canada Research Chair (Tier 1)
    Intrinsically Disordered Proteins

    3175     (Julie Forman-Kay)Apr 1, 2016 - Mar 31, 2019
    CFC
    Interactions of the Intrinsically Disordered Regulatory R Region of CFTR Involved in Phosphorylation-dependent Regulation

    PJT-148532     (Alan Moses)Apr 1, 2016 - Mar 31, 2021
    CIHR - Project Grant
    Predicting the impact of mutations in intrinsically disordered regions
    Role: Co-Applicant

    RGPIN-2016-06718     (Julie Forman-Kay)Apr 1, 2016 - Mar 31, 2021
    NSERC - Discovery Grant
    Pi interactions in monomeric and phase-separated disordered state ensembles

    FDN-148375     (Julie Forman-Kay)Jul 1, 2016 - Mar 31, 2024
    CIHR - Foundation Grant
    Discrete dynamic complexes and phase-separated states of disordered proteins in neurobiology

         (Julie Forman-Kay)Mar 15, 2017 - Jun 14, 2018
    Oncternal Therapeutics, LLC
    Measurement of Direct Binding of EWS-FLI1 antagonists to the FLI1 C-terminus using NMR Spectroscopy

    R01 GM127627-01     (Teresa Head-Gordon)May 1, 2018 - Jun 1, 2023
    NIH - Research Project Grant (R0l)
    Calculating Dynamic Ensembles of Intrinsically Disordered Proteins
    Role: Co-Applicant

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Zarin T, Strome B, Nguyen Ba AN, Alberti S, Forman-Kay JD, Moses AM. Proteome-wide signatures of function in highly diverged intrinsically disordered regions. Elife. 2019 Jul 02; 8. PMID: 31264965.
      View in: PubMed
    2. Vernon RM, Forman-Kay JD. First-generation predictors of biological protein phase separation. Curr Opin Struct Biol. 2019 Jun 25; 58:88-96. PMID: 31252218.
      View in: PubMed
    3. Ahmadi S, Wu YS, Li M, Ip W, Lloyd-Kuzik A, Di Paola M, Du K, Xia S, Lew A, Bozoky Z, Forman-Kay J, Bear CE, Gonska T. Augmentation of CFTR function in human bronchial epithelial cells via SLC6A14-dependent amino acid uptake: Implications for treatment of Cystic Fibrosis. Am J Respir Cell Mol Biol. 2019 Jun 12. PMID: 31189070.
      View in: PubMed
    4. Tsang B, Arsenault J, Vernon RM, Lin H, Sonenberg N, Wang LY, Bah A, Forman-Kay JD. Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation. Proc Natl Acad Sci U S A. 2019 Feb 14. PMID: 30765518.
      View in: PubMed
    5. Yang YM, Arsenault J, Bah A, Krzeminski M, Fekete A, Chao OY, Pacey LK, Wang A, Forman-Kay J, Hampson DR, Wang LY. Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain. Mol Psychiatry. 2018 Sep 17. PMID: 30224722.
      View in: PubMed
    6. Forman-Kay JD, Kriwacki RW, Seydoux G. Phase Separation in Biology and Disease. J Mol Biol. 2018 Nov 02; 430(23):4603-4606. PMID: 30213727.
      View in: PubMed
    7. Chong PA, Vernon RM, Forman-Kay JD. RGG/RG Motif Regions in RNA Binding and Phase Separation. J Mol Biol. 2018 Nov 02; 430(23):4650-4665. PMID: 29913160.
      View in: PubMed
    8. Tsafou K, Tiwari PB, Forman-Kay JD, Metallo SJ, Toretsky JA. Targeting Intrinsically Disordered Transcription Factors: Changing the Paradigm. J Mol Biol. 2018 08 03; 430(16):2321-2341. PMID: 29655986.
      View in: PubMed
    9. Lin YH, Forman-Kay JD, Chan HS. Theories for Sequence-Dependent Phase Behaviors of Biomolecular Condensates. Biochemistry. 2018 05 01; 57(17):2499-2508. PMID: 29509422.
      View in: PubMed
    10. Vernon RM, Chong PA, Tsang B, Kim TH, Bah A, Farber P, Lin H, Forman-Kay JD. Pi-Pi contacts are an overlooked protein feature relevant to phase separation. Elife. 2018 02 09; 7. PMID: 29424691.
      View in: PubMed
    11. Csizmok V, Montecchio M, Lin H, Tyers M, Sunnerhagen M, Forman-Kay JD. Multivalent Interactions with Fbw7 and Pin1 Facilitate Recognition of c-Jun by the SCFFbw7 Ubiquitin Ligase. Structure. 2018 01 02; 26(1):28-39.e2. PMID: 29225075.
      View in: PubMed
    12. Csizmok V, Forman-Kay JD. Complex regulatory mechanisms mediated by the interplay of multiple post-translational modifications. Curr Opin Struct Biol. 2018 02; 48:58-67. PMID: 29100108.
      View in: PubMed
    13. Brady JP, Farber PJ, Sekhar A, Lin YH, Huang R, Bah A, Nott TJ, Chan HS, Baldwin AJ, Forman-Kay JD, Kay LE. Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):E8194-E8203. PMID: 28894006.
      View in: PubMed
    14. Callebaut I, Chong PA, Forman-Kay JD. CFTR structure. J Cyst Fibros. 2018 03; 17(2S):S5-S8. PMID: 28866450.
      View in: PubMed
    15. Vernon RM, Chong PA, Lin H, Yang Z, Zhou Q, Aleksandrov AA, Dawson JE, Riordan JR, Brouillette CG, Thibodeau PH, Forman-Kay JD. Stabilization of a nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator yields insight into disease-causing mutations. J Biol Chem. 2017 08 25; 292(34):14147-14164. PMID: 28655774.
      View in: PubMed
    16. Hudson RP, Dawson JE, Chong PA, Yang Z, Millen L, Thomas PJ, Brouillette CG, Forman-Kay JD. Direct Binding of the Corrector VX-809 to Human CFTR NBD1: Evidence of an Allosteric Coupling between the Binding Site and the NBD1:CL4 Interface. Mol Pharmacol. 2017 08; 92(2):124-135. PMID: 28546419.
      View in: PubMed
    17. Scanlon DP, Bah A, Krzeminski M, Zhang W, Leduc-Pessah HL, Dong YN, Forman-Kay JD, Salter MW. An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors. Nat Commun. 2017 05 16; 8:15220. PMID: 28508887.
      View in: PubMed
    18. Ahmadi S, Bozoky Z, Di Paola M, Xia S, Li C, Wong AP, Wellhauser L, Molinski SV, Ip W, Ouyang H, Avolio J, Forman-Kay JD, Ratjen F, Hirota JA, Rommens J, Rossant J, Gonska T, Moraes TJ, Bear CE. Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia. NPJ Genom Med. 2017 Apr 14; 2:12. PMID: 28649446.
      View in: PubMed
    19. Malevanets A, Chong PA, Hansen DF, Rizk P, Sun Y, Lin H, Muhandiram R, Chakrabartty A, Kay LE, Forman-Kay JD, Wodak SJ. Interplay of buried histidine protonation and protein stability in prion misfolding. Sci Rep. 2017 04 13; 7(1):882. PMID: 28408762.
      View in: PubMed
    20. Chong PA, Forman-Kay JD. Molecular biology: A hidden competitive advantage of disorder. Nature. 2017 03 16; 543(7645):325-326. PMID: 28273062.
      View in: PubMed
    21. Bozoky Z, Ahmadi S, Milman T, Kim TH, Du K, Di Paola M, Pasyk S, Pekhletski R, Keller JP, Bear CE, Forman-Kay JD. Synergy of cAMP and calcium signaling pathways in CFTR regulation. Proc Natl Acad Sci U S A. 2017 03 14; 114(11):E2086-E2095. PMID: 28242698.
      View in: PubMed
    22. Csizmok V, Orlicky S, Cheng J, Song J, Bah A, Delgoshaie N, Lin H, Mittag T, Sicheri F, Chan HS, Tyers M, Forman-Kay JD. An allosteric conduit facilitates dynamic multisite substrate recognition by the SCFCdc4 ubiquitin ligase. Nat Commun. 2017 01 03; 8:13943. PMID: 28045046.
      View in: PubMed
    23. Yamada T, Krzeminski M, Bozoky Z, Forman-Kay JD, Strange K. Role of CBS and Bateman Domains in Phosphorylation-Dependent Regulation of a CLC Anion Channel. Biophys J. 2016 Nov 01; 111(9):1876-1886. PMID: 27806269.
      View in: PubMed
    24. Lin YH, Forman-Kay JD, Chan HS. Sequence-Specific Polyampholyte Phase Separation in Membraneless Organelles. Phys Rev Lett. 2016 Oct 21; 117(17):178101. PMID: 27824447.
      View in: PubMed
    25. Chong PA, Forman-Kay JD. A New Phase in ALS Research. Structure. 2016 09 06; 24(9):1435-6. PMID: 27602988.
      View in: PubMed
    26. Chong PA, Forman-Kay JD. Liquid-liquid phase separation in cellular signaling systems. Curr Opin Struct Biol. 2016 12; 41:180-186. PMID: 27552079.
      View in: PubMed
    27. Bhowmick A, Brookes DH, Yost SR, Dyson HJ, Forman-Kay JD, Gunter D, Head-Gordon M, Hura GL, Pande VS, Wemmer DE, Wright PE, Head-Gordon T. Finding Our Way in the Dark Proteome. J Am Chem Soc. 2016 08 10; 138(31):9730-42. PMID: 27387657.
      View in: PubMed
    28. Gakhal AK, Jensen TJ, Bozoky Z, Roldan A, Lukacs GL, Forman-Kay J, Riordan JR, Sidhu SS. Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator. MAbs. 2016 Aug-Sep; 8(6):1167-76. PMID: 27185291.
      View in: PubMed
    29. Wang TF, Dawson JE, Forman-Kay JD, Kahr WHA, Williams S, Chan AK, Kumar R. Molecular structural analysis of a novel and de-novo mutation in the SERPINC1 gene associated with type 1 antithrombin deficiency. Br J Haematol. 2017 05; 177(4):654-656. PMID: 27098850.
      View in: PubMed
    30. Mazouchi A, Zhang Z, Bahram A, Gomes GN, Lin H, Song J, Chan HS, Forman-Kay JD, Gradinaru CC. Conformations of a Metastable SH3 Domain Characterized by smFRET and an Excluded-Volume Polymer Model. Biophys J. 2016 Apr 12; 110(7):1510-1522. PMID: 27074677.
      View in: PubMed
    31. Csizmok V, Follis AV, Kriwacki RW, Forman-Kay JD. Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling. Chem Rev. 2016 06 08; 116(11):6424-62. PMID: 26922996.
      View in: PubMed
    32. Bah A, Forman-Kay JD. Modulation of Intrinsically Disordered Protein Function by Post-translational Modifications. J Biol Chem. 2016 Mar 25; 291(13):6696-705. PMID: 26851279.
      View in: PubMed
    33. Hall JD, Wang H, Byrnes LJ, Shanker S, Wang K, Efremov IV, Chong PA, Forman-Kay JD, Aulabaugh AE. Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy. Protein Sci. 2016 Feb; 25(2):360-73. PMID: 26444971.
      View in: PubMed
    34. Chong PA, Farber PJ, Vernon RM, Hudson RP, Mittermaier AK, Forman-Kay JD. Deletion of Phenylalanine 508 in the First Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Increases Conformational Exchange and Inhibits Dimerization. J Biol Chem. 2015 Sep 18; 290(38):22862-78. PMID: 26149808.
      View in: PubMed
    35. Nott TJ, Petsalaki E, Farber P, Jervis D, Fussner E, Plochowietz A, Craggs TD, Bazett-Jones DP, Pawson T, Forman-Kay JD, Baldwin AJ. Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles. Mol Cell. 2015 Mar 05; 57(5):936-947. PMID: 25747659.
      View in: PubMed
    36. Bah A, Vernon RM, Siddiqui Z, Krzeminski M, Muhandiram R, Zhao C, Sonenberg N, Kay LE, Forman-Kay JD. Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch. Nature. 2015 Mar 05; 519(7541):106-9. PMID: 25533957.
      View in: PubMed
    37. Kumar R, Dawson JE, Chan AK, Forman-Kay JD, Kahr WH, Williams S. c.1058C>T variant in the SERPINC1 gene is pathogenic for antithrombin deficiency. Br J Haematol. 2015 Jul; 170(1):123-5. PMID: 25522812.
      View in: PubMed
    38. Liu B, Chia D, Csizmok V, Farber P, Forman-Kay JD, Gradinaru CC. The effect of intrachain electrostatic repulsion on conformational disorder and dynamics of the Sic1 protein. J Phys Chem B. 2014 Apr 17; 118(15):4088-97. PMID: 24673507.
      View in: PubMed
    39. Kumar R, Chan AK, Dawson JE, Forman-Kay JD, Kahr WH, Williams S. Clinical presentation and molecular basis of congenital antithrombin deficiency in children: a cohort study. Br J Haematol. 2014 Jul; 166(1):130-9. PMID: 24684277.
      View in: PubMed
    40. Bozoky Z, Krzeminski M, Muhandiram R, Birtley JR, Al-Zahrani A, Thomas PJ, Frizzell RA, Ford RC, Forman-Kay JD. Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4427-36. PMID: 24191035.
      View in: PubMed
    41. Varadi M, Kosol S, Lebrun P, Valentini E, Blackledge M, Dunker AK, Felli IC, Forman-Kay JD, Kriwacki RW, Pierattelli R, Sussman J, Svergun DI, Uversky VN, Vendruscolo M, Wishart D, Wright PE, Tompa P. pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins. Nucleic Acids Res. 2014 Jan; 42(Database issue):D326-35. PMID: 24174539.
      View in: PubMed
    42. Lukhele S, Bah A, Lin H, Sonenberg N, Forman-Kay JD. Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface. Structure. 2013 Dec 03; 21(12):2186-96. PMID: 24207126.
      View in: PubMed
    43. Dawson JE, Farber PJ, Forman-Kay JD. Allosteric coupling between the intracellular coupling helix 4 and regulatory sites of the first nucleotide-binding domain of CFTR. PLoS One. 2013; 8(9):e74347. PMID: 24058550.
      View in: PubMed
    44. Pocanschi CL, Ehsani S, Mehrabian M, Wille H, Reginold W, Trimble WS, Wang H, Yee A, Arrowsmith CH, Bozóky Z, Kay LE, Forman-Kay JD, Rini JM, Schmitt-Ulms G. The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer. PLoS One. 2013; 8(9):e72446. PMID: 24039764.
      View in: PubMed
    45. Forman-Kay JD, Mittag T. From sequence and forces to structure, function, and evolution of intrinsically disordered proteins. Structure. 2013 Sep 03; 21(9):1492-9. PMID: 24010708.
      View in: PubMed
    46. Bozoky Z, Krzeminski M, Chong PA, Forman-Kay JD. Structural changes of CFTR R region upon phosphorylation: a plastic platform for intramolecular and intermolecular interactions. FEBS J. 2013 Sep; 280(18):4407-16. PMID: 23826884.
      View in: PubMed
    47. Dunker AK, Babu MM, Barbar E, Blackledge M, Bondos SE, Dosztányi Z, Dyson HJ, Forman-Kay J, Fuxreiter M, Gsponer J, Han KH, Jones DT, Longhi S, Metallo SJ, Nishikawa K, Nussinov R, Obradovic Z, Pappu RV, Rost B, Selenko P, Subramaniam V, Sussman JL, Tompa P, Uversky VN. What's in a name? Why these proteins are intrinsically disordered: Why these proteins are intrinsically disordered. Intrinsically Disord Proteins. 2013 Jan-Dec; 1(1):e24157. PMID: 28516007.
      View in: PubMed
    48. Chong PA, Kota P, Dokholyan NV, Forman-Kay JD. Dynamics intrinsic to cystic fibrosis transmembrane conductance regulator function and stability. Cold Spring Harb Perspect Med. 2013 Mar 01; 3(3):a009522. PMID: 23457292.
      View in: PubMed
    49. Stollar EJ, Lin H, Davidson AR, Forman-Kay JD. Differential dynamic engagement within 24 SH3 domain: peptide complexes revealed by co-linear chemical shift perturbation analysis. PLoS One. 2012; 7(12):e51282. PMID: 23251481.
      View in: PubMed
    50. Krzeminski M, Marsh JA, Neale C, Choy WY, Forman-Kay JD. Characterization of disordered proteins with ENSEMBLE. Bioinformatics. 2013 Feb 01; 29(3):398-9. PMID: 23233655.
      View in: PubMed
    51. Marsh JA, Teichmann SA, Forman-Kay JD. Probing the diverse landscape of protein flexibility and binding. Curr Opin Struct Biol. 2012 Oct; 22(5):643-50. PMID: 22999889.
      View in: PubMed
    52. Markley JL, Akutsu H, Asakura T, Baldus M, Boelens R, Bonvin A, Kaptein R, Bax A, Bezsonova I, Gryk MR, Hoch JC, Korzhnev DM, Maciejewski MW, Case D, Chazin WJ, Cross TA, Dames S, Kessler H, Lange O, Madl T, Reif B, Sattler M, Eliezer D, Fersht A, Forman-Kay J, Kay LE, Fraser J, Gross J, Kortemme T, Sali A, Fujiwara T, Gardner K, Luo X, Rizo-Rey J, Rosen M, Gil RR, Ho C, Rule G, Gronenborn AM, Ishima R, Klein-Seetharaman J, Tang P, van der Wel P, Xu Y, Grzesiek S, Hiller S, Seelig J, Laue ED, Mott H, Nietlispach D, Barsukov I, Lian LY, Middleton D, Blumenschein T, Moore G, Campbell I, Schnell J, Vakonakis IJ, Watts A, Conte MR, Mason J, Pfuhl M, Sanderson MR, Craven J, Williamson M, Dominguez C, Roberts G, Günther U, Overduin M, Werner J, Williamson P, Blindauer C, Crump M, Driscoll P, Frenkiel T, Golovanov A, Matthews S, Parkinson J, Uhrin D, Williams M, Neuhaus D, Oschkinat H, Ramos A, Shaw DE, Steinbeck C, Vendruscolo M, Vuister GW, Walters KJ, Weinstein H, Wüthrich K, Yokoyama S. In support of the BMRB. Nat Struct Mol Biol. 2012 Sep; 19(9):854-60. PMID: 22955930.
      View in: PubMed
    53. Hudson RP, Chong PA, Protasevich II, Vernon R, Noy E, Bihler H, An JL, Kalid O, Sela-Culang I, Mense M, Senderowitz H, Brouillette CG, Forman-Kay JD. Conformational changes relevant to channel activity and folding within the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator. J Biol Chem. 2012 Aug 17; 287(34):28480-94. PMID: 22722932.
      View in: PubMed
    54. Andresen C, Helander S, Lemak A, Farès C, Csizmok V, Carlsson J, Penn LZ, Forman-Kay JD, Arrowsmith CH, Lundström P, Sunnerhagen M. Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding. Nucleic Acids Res. 2012 Jul; 40(13):6353-66. PMID: 22457068.
      View in: PubMed
    55. Tang X, Orlicky S, Mittag T, Csizmok V, Pawson T, Forman-Kay JD, Sicheri F, Tyers M. Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase. Proc Natl Acad Sci U S A. 2012 Feb 28; 109(9):3287-92. PMID: 22328159.
      View in: PubMed
    56. Liang X, Da Paula AC, Bozóky Z, Zhang H, Bertrand CA, Peters KW, Forman-Kay JD, Frizzell RA. Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis. Mol Biol Cell. 2012 Mar; 23(6):996-1009. PMID: 22278744.
      View in: PubMed
    57. Tammam S, Sampaleanu LM, Koo J, Sundaram P, Ayers M, Chong PA, Forman-Kay JD, Burrows LL, Howell PL. Characterization of the PilN, PilO and PilP type IVa pilus subcomplex. Mol Microbiol. 2011 Dec; 82(6):1496-514. PMID: 22053789.
      View in: PubMed
    58. Marsh JA, Forman-Kay JD. Ensemble modeling of protein disordered states: experimental restraint contributions and validation. Proteins. 2012 Feb; 80(2):556-72. PMID: 22095648.
      View in: PubMed
    59. Kanelis V, Chong PA, Forman-Kay JD. NMR spectroscopy to study the dynamics and interactions of CFTR. Methods Mol Biol. 2011; 741:377-403. PMID: 21594798.
      View in: PubMed
    60. Pinheiro AS, Marsh JA, Forman-Kay JD, Peti W. Structural signature of the MYPT1-PP1 interaction. J Am Chem Soc. 2011 Jan 12; 133(1):73-80. PMID: 21142030.
      View in: PubMed
    61. Chong PA, Lin H, Wrana JL, Forman-Kay JD. Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity. Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43):18404-9. PMID: 20937913.
      View in: PubMed
    62. Fatemi N, Korzhnev DM, Velyvis A, Sarkar B, Forman-Kay JD. NMR characterization of copper-binding domains 4-6 of ATP7B . Biochemistry. 2010 Oct 05; 49(39):8468-77. PMID: 20799727.
      View in: PubMed
    63. Marsh JA, Dancheck B, Ragusa MJ, Allaire M, Forman-Kay JD, Peti W. Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulators. Structure. 2010 Sep 08; 18(9):1094-103. PMID: 20826336.
      View in: PubMed
    64. Marsh JA, Forman-Kay JD. Sequence determinants of compaction in intrinsically disordered proteins. Biophys J. 2010 May 19; 98(10):2383-90. PMID: 20483348.
      View in: PubMed
    65. Mittag T, Marsh J, Grishaev A, Orlicky S, Lin H, Sicheri F, Tyers M, Forman-Kay JD. Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase. Structure. 2010 Mar 14; 18(4):494-506. PMID: 20399186.
      View in: PubMed
    66. Mittag T, Kay LE, Forman-Kay JD. Protein dynamics and conformational disorder in molecular recognition. J Mol Recognit. 2010 Mar-Apr; 23(2):105-16. PMID: 19585546.
      View in: PubMed
    67. Chevelkov V, Xue Y, Rao DK, Forman-Kay JD, Skrynnikov NR. 15N H/D-SOLEXSY experiment for accurate measurement of amide solvent exchange rates: application to denatured drkN SH3. J Biomol NMR. 2010 Mar; 46(3):227-44. PMID: 20195703.
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    68. Ogunjimi AA, Wiesner S, Briant DJ, Varelas X, Sicheri F, Forman-Kay J, Wrana JL. The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates. J Biol Chem. 2010 Feb 26; 285(9):6308-15. PMID: 20026602.
      View in: PubMed
    69. Kahr WH, Savoia A, Pluthero FG, Li L, Christensen H, De Rocco D, Traivaree C, Butchart SE, Curtin J, Stollar EJ, Forman-Kay JD, Blanchette VS. Megakaryocyte and platelet abnormalities in a patient with a W33C mutation in the conserved SH3-like domain of myosin heavy chain IIA. Thromb Haemost. 2009 Dec; 102(6):1241-50. PMID: 19967157.
      View in: PubMed
    70. Kanelis V, Hudson RP, Thibodeau PH, Thomas PJ, Forman-Kay JD. NMR evidence for differential phosphorylation-dependent interactions in WT and DeltaF508 CFTR. EMBO J. 2010 Jan 06; 29(1):263-77. PMID: 19927121.
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    71. Murphy JM, Hansen DF, Wiesner S, Muhandiram DR, Borg M, Smith MJ, Sicheri F, Kay LE, Forman-Kay JD, Pawson T. Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays. J Mol Biol. 2009 Oct 23; 393(2):409-24. PMID: 19715701.
      View in: PubMed
    72. Stollar EJ, Garcia B, Chong PA, Rath A, Lin H, Forman-Kay JD, Davidson AR. Structural, functional, and bioinformatic studies demonstrate the crucial role of an extended peptide binding site for the SH3 domain of yeast Abp1p. J Biol Chem. 2009 Sep 25; 284(39):26918-27. PMID: 19590096.
      View in: PubMed
    73. Marsh JA, Forman-Kay JD. Structure and disorder in an unfolded state under nondenaturing conditions from ensemble models consistent with a large number of experimental restraints. J Mol Biol. 2009 Aug 14; 391(2):359-74. PMID: 19501099.
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    74. Mittag T, Orlicky S, Choy WY, Tang X, Lin H, Sicheri F, Kay LE, Tyers M, Forman-Kay JD. Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17772-7. PMID: 19008353.
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    75. Bezsonova I, Bruce MC, Wiesner S, Lin H, Rotin D, Forman-Kay JD. Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination. Biochemistry. 2008 Aug 26; 47(34):8937-49. PMID: 18680311.
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    76. Marsh JA, Baker JM, Tollinger M, Forman-Kay JD. Calculation of residual dipolar couplings from disordered state ensembles using local alignment. J Am Chem Soc. 2008 Jun 25; 130(25):7804-5. PMID: 18512919.
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    77. Dorwart MR, Shcheynikov N, Baker JM, Forman-Kay JD, Muallem S, Thomas PJ. Congenital chloride-losing diarrhea causing mutations in the STAS domain result in misfolding and mistrafficking of SLC26A3. J Biol Chem. 2008 Mar 28; 283(13):8711-22. PMID: 18216024.
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    78. Wiesner S, Ogunjimi AA, Wang HR, Rotin D, Sicheri F, Wrana JL, Forman-Kay JD. Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell. 2007 Aug 24; 130(4):651-62. PMID: 17719543.
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    79. Baker JM, Hudson RP, Kanelis V, Choy WY, Thibodeau PH, Thomas PJ, Forman-Kay JD. CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices. Nat Struct Mol Biol. 2007 Aug; 14(8):738-45. PMID: 17660831.
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    80. Borg M, Mittag T, Pawson T, Tyers M, Forman-Kay JD, Chan HS. Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity. Proc Natl Acad Sci U S A. 2007 Jun 05; 104(23):9650-5. PMID: 17522259.
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    81. Bezsonova I, Evanics F, Marsh JA, Forman-Kay JD, Prosser RS. Oxygen as a paramagnetic probe of clustering and solvent exposure in folded and unfolded states of an SH3 domain. J Am Chem Soc. 2007 Feb 14; 129(6):1826-35. PMID: 17253684.
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    82. Mittag T, Forman-Kay JD. Atomic-level characterization of disordered protein ensembles. Curr Opin Struct Biol. 2007 Feb; 17(1):3-14. PMID: 17250999.
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    83. Marsh JA, Neale C, Jack FE, Choy WY, Lee AY, Crowhurst KA, Forman-Kay JD. Improved structural characterizations of the drkN SH3 domain unfolded state suggest a compact ensemble with native-like and non-native structure. J Mol Biol. 2007 Apr 13; 367(5):1494-510. PMID: 17320108.
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    84. Singh VK, Zhou Y, Marsh JA, Uversky VN, Forman-Kay JD, Liu J, Jia Z. Synuclein-gamma targeting peptide inhibitor that enhances sensitivity of breast cancer cells to antimicrotubule drugs. Cancer Res. 2007 Jan 15; 67(2):626-33. PMID: 17234772.
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    85. Evanics F, Bezsonova I, Marsh J, Kitevski JL, Forman-Kay JD, Prosser RS. Tryptophan solvent exposure in folded and unfolded states of an SH3 domain by 19F and 1H NMR. Biochemistry. 2006 Nov 28; 45(47):14120-8. PMID: 17115707.
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    86. Evanics F, Kitevski JL, Bezsonova I, Forman-Kay J, Prosser RS. 19F NMR studies of solvent exposure and peptide binding to an SH3 domain. Biochim Biophys Acta. 2007 Feb; 1770(2):221-30. PMID: 17182189.
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    87. Marsh JA, Singh VK, Jia Z, Forman-Kay JD. Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: implications for fibrillation. Protein Sci. 2006 Dec; 15(12):2795-804. PMID: 17088319.
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    88. Wiesner S, Wybenga-Groot LE, Warner N, Lin H, Pawson T, Forman-Kay JD, Sicheri F. A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases. EMBO J. 2006 Oct 04; 25(19):4686-96. PMID: 16977320.
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    89. Tollinger M, Neale C, Kay LE, Forman-Kay JD. Characterization of the hydrodynamic properties of the folding transition state of an SH3 domain by magnetization transfer NMR spectroscopy. Biochemistry. 2006 May 23; 45(20):6434-45. PMID: 16700554.
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    90. Chong PA, Lin H, Wrana JL, Forman-Kay JD. An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2. J Biol Chem. 2006 Jun 23; 281(25):17069-75. PMID: 16641086.
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    91. Bezsonova I, Korzhnev DM, Prosser RS, Forman-Kay JD, Kay LE. Hydration and packing along the folding pathway of SH3 domains by pressure-dependent NMR. Biochemistry. 2006 Apr 18; 45(15):4711-9. PMID: 16605239.
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    92. Kanelis V, Bruce MC, Skrynnikov NR, Rotin D, Forman-Kay JD. Structural determinants for high-affinity binding in a Nedd4 WW3* domain-Comm PY motif complex. Structure. 2006 Mar; 14(3):543-53. PMID: 16531238.
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    93. Bezsonova I, Singer A, Choy WY, Tollinger M, Forman-Kay JD. Structural comparison of the unstable drkN SH3 domain and a stable mutant. Biochemistry. 2005 Nov 29; 44(47):15550-60. PMID: 16300404.
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    94. Tollinger M, Kay LE, Forman-Kay JD. Measuring pK(a) values in protein folding transition state ensembles by NMR spectroscopy. J Am Chem Soc. 2005 Jun 29; 127(25):8904-5. PMID: 15969539.
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    95. Finerty PJ, Mittermaier AK, Muhandiram R, Kay LE, Forman-Kay JD. NMR dynamics-derived insights into the binding properties of a peptide interacting with an SH2 domain. Biochemistry. 2005 Jan 18; 44(2):694-703. PMID: 15641795.
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    96. Chong PA, Ozdamar B, Wrana JL, Forman-Kay JD. Disorder in a target for the smad2 mad homology 2 domain and its implications for binding and specificity. J Biol Chem. 2004 Sep 24; 279(39):40707-14. PMID: 15231848.
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    97. Crowhurst KA, Forman-Kay JD. Aromatic and methyl NOEs highlight hydrophobic clustering in the unfolded state of an SH3 domain. Biochemistry. 2003 Jul 29; 42(29):8687-95. PMID: 12873128.
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    98. Tollinger M, Crowhurst KA, Kay LE, Forman-Kay JD. Site-specific contributions to the pH dependence of protein stability. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4545-50. PMID: 12671071.
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    99. Henry PC, Kanelis V, O'Brien MC, Kim B, Gautschi I, Forman-Kay J, Schild L, Rotin D. Affinity and specificity of interactions between Nedd4 isoforms and the epithelial Na+ channel. J Biol Chem. 2003 May 30; 278(22):20019-28. PMID: 12654927.
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    100. Donaldson LW, Gish G, Pawson T, Kay LE, Forman-Kay JD. Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14053-8. PMID: 12384576.
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    101. Hwang PM, Choy WY, Lo EI, Chen L, Forman-Kay JD, Raetz CR, Privé GG, Bishop RE, Kay LE. Solution structure and dynamics of the outer membrane enzyme PagP by NMR. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13560-5. PMID: 12357033.
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    102. Finerty PJ, Muhandiram R, Forman-Kay JD. Side-chain dynamics of the SAP SH2 domain correlate with a binding hot spot and a region with conformational plasticity. J Mol Biol. 2002 Sep 20; 322(3):605-20. PMID: 12225753.
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    103. Crowhurst KA, Tollinger M, Forman-Kay JD. Cooperative interactions and a non-native buried Trp in the unfolded state of an SH3 domain. J Mol Biol. 2002 Sep 06; 322(1):163-78. PMID: 12215422.
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    104. Tollinger M, Forman-Kay JD, Kay LE. Measurement of side-chain carboxyl pK(a) values of glutamate and aspartate residues in an unfolded protein by multinuclear NMR spectroscopy. J Am Chem Soc. 2002 May 22; 124(20):5714-7. PMID: 12010044.
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    105. Choy WY, Mulder FA, Crowhurst KA, Muhandiram DR, Millett IS, Doniach S, Forman-Kay JD, Kay LE. Distribution of molecular size within an unfolded state ensemble using small-angle X-ray scattering and pulse field gradient NMR techniques. J Mol Biol. 2002 Feb 08; 316(1):101-12. PMID: 11829506.
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    106. Hwang PM, Li C, Morra M, Lillywhite J, Muhandiram DR, Gertler F, Terhorst C, Kay LE, Pawson T, Forman-Kay JD, Li SC. A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J. 2002 Feb 01; 21(3):314-23. PMID: 11823424.
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    107. Kanelis V, Forman-Kay JD, Kay LE. Multidimensional NMR methods for protein structure determination. IUBMB Life. 2001 Dec; 52(6):291-302. PMID: 11895078.
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    108. Tollinger M, Skrynnikov NR, Mulder FA, Forman-Kay JD, Kay LE. Slow dynamics in folded and unfolded states of an SH3 domain. J Am Chem Soc. 2001 Nov 21; 123(46):11341-52. PMID: 11707108.
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    109. Donaldson LW, Skrynnikov NR, Choy WY, Muhandiram DR, Sarkar B, Forman-Kay JD, Kay LE. Structural characterization of proteins with an attached ATCUN motif by paramagnetic relaxation enhancement NMR spectroscopy. J Am Chem Soc. 2001 Oct 10; 123(40):9843-7. PMID: 11583547.
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    110. Choy WY, Forman-Kay JD. Calculation of ensembles of structures representing the unfolded state of an SH3 domain. J Mol Biol. 2001 May 18; 308(5):1011-32. PMID: 11352588.
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    111. Kanelis V, Rotin D, Forman-Kay JD. Solution structure of a Nedd4 WW domain-ENaC peptide complex. Nat Struct Biol. 2001 May; 8(5):407-12. PMID: 11323714.
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    112. Mok YK, Elisseeva EL, Davidson AR, Forman-Kay JD. Dramatic stabilization of an SH3 domain by a single substitution: roles of the folded and unfolded states. J Mol Biol. 2001 Mar 30; 307(3):913-28. PMID: 11273710.
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    113. Mueller GA, Choy WY, Yang D, Forman-Kay JD, Venters RA, Kay LE. Global folds of proteins with low densities of NOEs using residual dipolar couplings: application to the 370-residue maltodextrin-binding protein. J Mol Biol. 2000 Jun 30; 300(1):197-212. PMID: 10864509.
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    114. Kortemme T, Kelly MJ, Kay LE, Forman-Kay J, Serrano L. Similarities between the spectrin SH3 domain denatured state and its folding transition state. J Mol Biol. 2000 Apr 14; 297(5):1217-29. PMID: 10764585.
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    115. Zwahlen C, Li SC, Kay LE, Pawson T, Forman-Kay JD. Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb. EMBO J. 2000 Apr 03; 19(7):1505-15. PMID: 10747019.
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    116. Kanelis V, Donaldson L, Muhandiram DR, Rotin D, Forman-Kay JD, Kay LE. Sequential assignment of proline-rich regions in proteins: application to modular binding domain complexes. J Biomol NMR. 2000 Mar; 16(3):253-9. PMID: 10805132.
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    117. Li SC, Gish G, Yang D, Coffey AJ, Forman-Kay JD, Ernberg I, Kay LE, Pawson T. Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A. Curr Biol. 1999 Dec 02; 9(23):1355-62. PMID: 10607564.
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    118. Forman-Kay JD, Pawson T. Diversity in protein recognition by PTB domains. Curr Opin Struct Biol. 1999 Dec; 9(6):690-5. PMID: 10607674.
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    119. Forman-Kay JD. The 'dynamics' in the thermodynamics of binding. Nat Struct Biol. 1999 Dec; 6(12):1086-7. PMID: 10581541.
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    120. Maxwell KL, Mittermaier AK, Forman-Kay JD, Davidson AR. A simple in vivo assay for increased protein solubility. Protein Sci. 1999 Sep; 8(9):1908-11. PMID: 10493593.
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    121. Mok YK, Kay CM, Kay LE, Forman-Kay J. NOE data demonstrating a compact unfolded state for an SH3 domain under non-denaturing conditions. J Mol Biol. 1999 Jun 11; 289(3):619-38. PMID: 10356333.
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    122. Mittermaier A, Kay LE, Forman-Kay JD. Analysis of deuterium relaxation-derived methyl axis order parameters and correlation with local structure. J Biomol NMR. 1999 Feb; 13(2):181-5. PMID: 20700817.
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    123. Blanco FJ, Serrano L, Forman-Kay JD. High populations of non-native structures in the denatured state are compatible with the formation of the native folded state. J Mol Biol. 1998 Dec 11; 284(4):1153-64. PMID: 9837733.
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    124. Li SC, Zwahlen C, Vincent SJ, McGlade CJ, Kay LE, Pawson T, Forman-Kay JD. Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity. Nat Struct Biol. 1998 Dec; 5(12):1075-83. PMID: 9846878.
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    125. Kay LE, Muhandiram DR, Wolf G, Shoelson SE, Forman-Kay JD. Correlation between binding and dynamics at SH2 domain interfaces. Nat Struct Biol. 1998 Feb; 5(2):156-63. PMID: 9461082.
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    126. Kanelis V, Farrow NA, Kay LE, Rotin D, Forman-Kay JD. NMR studies of tandem WW domains of Nedd4 in complex with a PY motif-containing region of the epithelial sodium channel. Biochem Cell Biol. 1998; 76(2-3):341-50. PMID: 9923703.
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    127. Wang A, Forman-Kay J, Luo Y, Luo M, Chow YH, Plumb J, Friesen JD, Tsui LC, Heng HH, Woolford JL, Hu J. Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome. Hum Mol Genet. 1997 Nov; 6(12):2117-26. PMID: 9328476.
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    128. Yang D, Mok YK, Forman-Kay JD, Farrow NA, Kay LE. Contributions to protein entropy and heat capacity from bond vector motions measured by NMR spin relaxation. J Mol Biol. 1997 Oct 10; 272(5):790-804. PMID: 9368658.
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    129. Zhang O, Kay LE, Shortle D, Forman-Kay JD. Comprehensive NOE characterization of a partially folded large fragment of staphylococcal nuclease Delta131Delta, using NMR methods with improved resolution. J Mol Biol. 1997 Sep 12; 272(1):9-20. PMID: 9299333.
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    130. Singer AU, Forman-Kay JD. pH titration studies of an SH2 domain-phosphopeptide complex: unusual histidine and phosphate pKa values. Protein Sci. 1997 Sep; 6(9):1910-9. PMID: 9300491.
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    131. Li SC, Songyang Z, Vincent SJ, Zwahlen C, Wiley S, Cantley L, Kay LE, Forman-Kay J, Pawson T. High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif. Proc Natl Acad Sci U S A. 1997 Jul 08; 94(14):7204-9. PMID: 9207069.
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    132. Gasmi G, Singer A, Forman-Kay J, Sarkar B. NMR structure of neuromedin C, a neurotransmitter with an amino terminal CuII-, NiII-binding (ATCUN) motif. J Pept Res. 1997 Jun; 49(6):500-9. PMID: 9266477.
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    133. Zhang O, Forman-Kay JD. NMR studies of unfolded states of an SH3 domain in aqueous solution and denaturing conditions. Biochemistry. 1997 Apr 01; 36(13):3959-70. PMID: 9092826.
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    134. Farrow NA, Zhang O, Forman-Kay JD, Kay LE. Characterization of the backbone dynamics of folded and denatured states of an SH3 domain. Biochemistry. 1997 Mar 04; 36(9):2390-402. PMID: 9054544.
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    135. Zhang O, Forman-Kay JD, Shortle D, Kay LE. Triple-resonance NOESY-based experiments with improved spectral resolution: applications to structural characterization of unfolded, partially folded and folded proteins. J Biomol NMR. 1997 Feb; 9(2):181-200. PMID: 9090132.
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    136. Li SC, Lai KM, Gish GD, Parris WE, van der Geer P, Forman-Kay J, Pawson T. Characterization of the phosphotyrosine-binding domain of the Drosophila Shc protein. J Biol Chem. 1996 Dec 13; 271(50):31855-62. PMID: 8943228.
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    137. Kay LE, Muhandiram DR, Farrow NA, Aubin Y, Forman-Kay JD. Correlation between dynamics and high affinity binding in an SH2 domain interaction. Biochemistry. 1996 Jan 16; 35(2):361-8. PMID: 8555205.
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    138. Pascal SM, Singer AU, Yamazaki T, Kay LE, Forman-Kay JD. Structural and dynamic characterization of an SH2 domain-phosphopeptide complex by NMR approaches. Biochem Soc Trans. 1995 Nov; 23(4):729-33. PMID: 8654826.
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    139. Pascal SM, Yamazaki T, Singer AU, Kay LE, Forman-Kay JD. Structural and dynamic characterization of the phosphotyrosine binding region of a Src homology 2 domain--phosphopeptide complex by NMR relaxation, proton exchange, and chemical shift approaches. Biochemistry. 1995 Sep 12; 34(36):11353-62. PMID: 7547863.
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    140. Zhang O, Forman-Kay JD. Structural characterization of folded and unfolded states of an SH3 domain in equilibrium in aqueous buffer. Biochemistry. 1995 May 23; 34(20):6784-94. PMID: 7756310.
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    141. Farrow NA, Zhang O, Forman-Kay JD, Kay LE. Comparison of the backbone dynamics of a folded and an unfolded SH3 domain existing in equilibrium in aqueous buffer. Biochemistry. 1995 Jan 24; 34(3):868-78. PMID: 7827045.
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    142. Zhang O, Kay LE, Olivier JP, Forman-Kay JD. Backbone 1H and 15N resonance assignments of the N-terminal SH3 domain of drk in folded and unfolded states using enhanced-sensitivity pulsed field gradient NMR techniques. J Biomol NMR. 1994 Nov; 4(6):845-58. PMID: 7812156.
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    143. Farrow NA, Zhang O, Forman-Kay JD, Kay LE. A heteronuclear correlation experiment for simultaneous determination of 15N longitudinal decay and chemical exchange rates of systems in slow equilibrium. J Biomol NMR. 1994 Sep; 4(5):727-34. PMID: 7919956.
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    144. Farrow NA, Muhandiram R, Singer AU, Pascal SM, Kay CM, Gish G, Shoelson SE, Pawson T, Forman-Kay JD, Kay LE. Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation. Biochemistry. 1994 May 17; 33(19):5984-6003. PMID: 7514039.
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    145. Pascal SM, Singer AU, Gish G, Yamazaki T, Shoelson SE, Pawson T, Kay LE, Forman-Kay JD. Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide. Cell. 1994 May 06; 77(3):461-72. PMID: 8181064.
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    146. Forman-Kay JD, Clore GM, Stahl SJ, Gronenborn AM. 1H and 15N resonance assignments and secondary structure of the human thioredoxin C62A, C69A, C73A mutant. J Biomol NMR. 1992 Sep; 2(5):431-45. PMID: 1422155.
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    147. Forman-Kay JD, Clore GM, Gronenborn AM. Relationship between electrostatics and redox function in human thioredoxin: characterization of pH titration shifts using two-dimensional homo- and heteronuclear NMR. Biochemistry. 1992 Apr 07; 31(13):3442-52. PMID: 1554726.
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    148. Forman-Kay JD, Gronenborn AM, Wingfield PT, Clore GM. Determination of the positions of bound water molecules in the solution structure of reduced human thioredoxin by heteronuclear three-dimensional nuclear magnetic resonance spectroscopy. J Mol Biol. 1991 Jul 20; 220(2):209-16. PMID: 1856855.
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    149. Kay LE, Forman-Kay JD, McCubbin WD, Kay CM. Solution structure of a polypeptide dimer comprising the fourth Ca(2+)-binding site of troponin C by nuclear magnetic resonance spectroscopy. Biochemistry. 1991 Apr 30; 30(17):4323-33. PMID: 2021624.
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    150. Forman-Kay JD, Clore GM, Wingfield PT, Gronenborn AM. High-resolution three-dimensional structure of reduced recombinant human thioredoxin in solution. Biochemistry. 1991 Mar 12; 30(10):2685-98. PMID: 2001356.
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    151. Forman-Kay JD, Clore GM, Driscoll PC, Wingfield P, Richards FM, Gronenborn AM. A proton nuclear magnetic resonance assignment and secondary structure determination of recombinant human thioredoxin. Biochemistry. 1989 Aug 22; 28(17):7088-97. PMID: 2684271.
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