 Transglutaminases
"Transglutaminases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.
| Descriptor ID |
D011503
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| MeSH Number(s) |
D08.811.913.050.200.800
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| Concept/Terms |
Transglutaminases- Transglutaminases
- Protein-Glutamine gamma-Glutamyltransferases
- Protein Glutamine gamma Glutamyltransferases
- gamma-Glutamyltransferases, Protein-Glutamine
- Glutaminyl-Peptide Gamma-Glutamyltransferases
- Gamma-Glutamyltransferases, Glutaminyl-Peptide
- Glutaminyl Peptide Gamma Glutamyltransferases
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Below are MeSH descriptors whose meaning is more general than "Transglutaminases".
Below are MeSH descriptors whose meaning is more specific than "Transglutaminases".
This graph shows the total number of publications written about "Transglutaminases" by people in this website by year, and whether "Transglutaminases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2019 | 0 | 2 | 2 |
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Below are the most recent publications written about "Transglutaminases" by people in Profiles.
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Gould MJ, Brill H, Marcon MA, Walsh CM. Response to: In Screening for Celiac Disease, Deamidated Gliadin Rarely Predicts Disease When Tissue Transglutaminase Is Normal. J Pediatr Gastroenterol Nutr. 2019;68(1):20-25. J Pediatr Gastroenterol Nutr. 2019 07; 69(1):e23-e24.
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Gould MJ, Brill H, Marcon MA, Munn NJ, Walsh CM. In Screening for Celiac Disease, Deamidated Gliadin Rarely Predicts Disease When Tissue Transglutaminase Is Normal. J Pediatr Gastroenterol Nutr. 2019 01; 68(1):20-25.
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Atzeni F, Doria A, Ghirardello A, Villalta D, Zampieri S, Carrabba M, Sarzi-Puttini P. Organ-specific autoantibodies in patients with rheumatoid arthritis treated with adalimumab: a prospective long-term follow-up. Autoimmunity. 2008 Feb; 41(1):87-91.
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Mahmud FH, Murray JA, Kudva YC, Zinsmeister AR, Dierkhising RA, Lahr BD, Dyck PJ, Kyle RA, El-Youssef M, Burgart LJ, Van Dyke CT, Brogan DL, Melton LJ. Celiac disease in type 1 diabetes mellitus in a North American community: prevalence, serologic screening, and clinical features. Mayo Clin Proc. 2005 Nov; 80(11):1429-34.
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Marai I, Shoenfeld Y, Bizzaro N, Villalta D, Doria A, Tonutti E, Tozzoli R. IgA and IgG tissue transglutaminase antibodies in systemic lupus erythematosus. Lupus. 2004; 13(4):241-4.
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Bizzaro N, Villalta D, Tonutti E, Doria A, Tampoia M, Bassetti D, Tozzoli R. IgA and IgG tissue transglutaminase antibody prevalence and clinical significance in connective tissue diseases, inflammatory bowel disease, and primary biliary cirrhosis. Dig Dis Sci. 2003 Dec; 48(12):2360-5.
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