 1-Phosphatidylinositol 4-Kinase
"1-Phosphatidylinositol 4-Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of phosphatidylinositol (PHOSPHATIDYLINOSITOLS) to phosphatidylinositol 4-phosphate, the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.
| Descriptor ID |
D019870
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| MeSH Number(s) |
D08.811.913.696.620.550
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| Concept/Terms |
1-Phosphatidylinositol 4-Kinase- 1-Phosphatidylinositol 4-Kinase
- 1 Phosphatidylinositol 4 Kinase
- Phosphoinositide Kinase
- Kinase, Phosphoinositide
- Phosphatidylinositiol Kinase
- Kinase, Phosphatidylinositiol
- Phosphatidylinositol 4-Kinase
- Phosphatidylinositol 4 Kinase
- PI 4-Kinase
- PI 4 Kinase
- Phosphatidylinositol Kinase Type II
- PtdIns 4-Kinase
- PtdIns 4 Kinase
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Below are MeSH descriptors whose meaning is more general than "1-Phosphatidylinositol 4-Kinase".
Below are MeSH descriptors whose meaning is more specific than "1-Phosphatidylinositol 4-Kinase".
This graph shows the total number of publications written about "1-Phosphatidylinositol 4-Kinase" by people in this website by year, and whether "1-Phosphatidylinositol 4-Kinase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 0 | 1 | 1 | | 2000 | 1 | 0 | 1 | | 2009 | 1 | 0 | 1 | | 2012 | 2 | 0 | 2 | | 2013 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "1-Phosphatidylinositol 4-Kinase" by people in Profiles.
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López-Haber C, Levin-Konigsberg R, Zhu Y, Bi-Karchin J, Balla T, Grinstein S, Marks MS, Mantegazza AR. Phosphatidylinositol-4-kinase IIa licenses phagosomes for TLR4 signaling and MHC-II presentation in dendritic cells. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28251-28262.
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Cantarutti KC, Burgess J, Brill JA, Dason JS. Type II phosphatidylinositol 4-kinase regulates nerve terminal growth and synaptic vesicle recycling. J Neurogenet. 2018 09; 32(3):230-235.
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Avitzur Y, Guo C, Mastropaolo LA, Bahrami E, Chen H, Zhao Z, Elkadri A, Dhillon S, Murchie R, Fattouh R, Huynh H, Walker JL, Wales PW, Cutz E, Kakuta Y, Dudley J, Kammermeier J, Powrie F, Shah N, Walz C, Nathrath M, Kotlarz D, Puchaka J, Krieger JR, Racek T, Kirchner T, Walters TD, Brumell JH, Griffiths AM, Rezaei N, Rashtian P, Najafi M, Monajemzadeh M, Pelsue S, McGovern DP, Uhlig HH, Schadt E, Klein C, Snapper SB, Muise AM. Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease. Gastroenterology. 2014 Apr; 146(4):1028-39.
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Tan J, Brill JA. Cinderella story: PI4P goes from precursor to key signaling molecule. Crit Rev Biochem Mol Biol. 2014 Jan-Feb; 49(1):33-58.
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Burgess J, Del Bel LM, Ma CI, Barylko B, Polevoy G, Rollins J, Albanesi JP, Krämer H, Brill JA. Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila. Development. 2012 Aug; 139(16):3040-50.
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Jovic M, Kean MJ, Szentpetery Z, Polevoy G, Gingras AC, Brill JA, Balla T. Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, ß-glucocerebrosidase. Mol Biol Cell. 2012 Apr; 23(8):1533-45.
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Polevoy G, Wei HC, Wong R, Szentpetery Z, Kim YJ, Goldbach P, Steinbach SK, Balla T, Brill JA. Dual roles for the Drosophila PI 4-kinase four wheel drive in localizing Rab11 during cytokinesis. J Cell Biol. 2009 Dec 14; 187(6):847-58.
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Brill JA, Hime GR, Scharer-Schuksz M, Fuller MT. A phospholipid kinase regulates actin organization and intercellular bridge formation during germline cytokinesis. Development. 2000 Sep; 127(17):3855-64.
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Fixman ED, Naujokas MA, Rodrigues GA, Moran MF, Park M. Efficient cell transformation by the Tpr-Met oncoprotein is dependent upon tyrosine 489 in the carboxy-terminus. Oncogene. 1995 Jan 19; 10(2):237-49.
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