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Miguel Cortez

TitleStaff Neurophysiologist
InstitutionThe Hospital for Sick Children
DepartmentNeurology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jain P, Gulati P, Alsowat D, Cortez MA, Carter Snead O, Whitney R. Perineal stimulation triggering seizures in a child with Dravet syndrome. Seizure. 2018 11; 62:106-107. PMID: 30336400.
      View in: PubMed
    2. Joshi K, Shen L, Cao F, Dong S, Jia Z, Cortez MA, Snead OC. Kcnj6(GIRK2) trisomy is not sufficient for conferring the susceptibility to infantile spasms seen in the Ts65Dn mouse model of down syndrome. Epilepsy Res. 2018 09; 145:82-88. PMID: 29929098.
      View in: PubMed
    3. Leung C, Cao F, Nguyen R, Joshi K, Aqrabawi AJ, Xia S, Cortez MA, Snead OC, Kim JC, Jia Z. Activation of Entorhinal Cortical Projections to the Dentate Gyrus Underlies Social Memory Retrieval. Cell Rep. 2018 May 22; 23(8):2379-2391. PMID: 29791849.
      View in: PubMed
    4. Nenadovic V, Whitney R, Boulet J, Cortez MA. Hypsarrhythmia in epileptic spasms: Synchrony in chaos. Seizure. 2018 May; 58:55-61. PMID: 29656099.
      View in: PubMed
    5. Liu JJ, Grace KP, Horner RL, Cortez MA, Shao Y, Jia Z. Neuroligin 3 R451C mutation alters electroencephalography spectral activity in an animal model of autism spectrum disorders. Mol Brain. 2017 04 07; 10(1):10. PMID: 28385162.
      View in: PubMed
    6. Wielaender F, Sarviaho R, James F, Hytönen MK, Cortez MA, Kluger G, Koskinen LL, Arumilli M, Kornberg M, Bathen-Noethen A, Tipold A, Rentmeister K, Bhatti SF, Hülsmeyer V, Boettcher IC, Tästensen C, Flegel T, Dietschi E, Leeb T, Matiasek K, Fischer A, Lohi H. Generalized myoclonic epilepsy with photosensitivity in juvenile dogs caused by a defective DIRAS family GTPase 1. Proc Natl Acad Sci U S A. 2017 03 07; 114(10):2669-2674. PMID: 28223533.
      View in: PubMed
    7. Joshi K, Shen L, Michaeli A, Salter M, Thibault-Messier G, Hashmi S, Eubanks JH, Cortez MA, Snead OC. Infantile spasms in down syndrome: Rescue by knockdown of the GIRK2 channel. Ann Neurol. 2016 10; 80(4):511-21. PMID: 27462820.
      View in: PubMed
    8. Schulze A, Tran C, Levandovskiy V, Patel V, Cortez MA. Systemic availability of guanidinoacetate affects GABAA receptor function and seizure threshold in GAMT deficient mice. Amino Acids. 2016 08; 48(8):2041-7. PMID: 26898547.
      View in: PubMed
    9. Cortez MA, Kostopoulos GK, Snead OC. Acute and chronic pharmacological models of generalized absence seizures. J Neurosci Methods. 2016 Feb 15; 260:175-84. PMID: 26343323.
      View in: PubMed
    10. Blichowski M, Shephard A, Armstrong J, Shen L, Cortez MA, Eubanks JH, Snead OC. The GIRK2 subunit is involved in IS-like seizures induced by GABA(B) receptor agonists. Epilepsia. 2015 Jul; 56(7):1081-7. PMID: 26032891.
      View in: PubMed
    11. Todorovski Z, Asrar S, Liu J, Saw NM, Joshi K, Cortez MA, Snead OC, Xie W, Jia Z. LIMK1 regulates long-term memory and synaptic plasticity via the transcriptional factor CREB. Mol Cell Biol. 2015 Apr; 35(8):1316-28. PMID: 25645926; PMCID: PMC4372699.
    12. Whitney R, Moharir M, Allen A, Cortez MA. Paroxysmal alpha activity in Rett syndrome: a case report. Pediatr Neurol. 2014 Sep; 51(3):421-5. PMID: 25160549.
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    13. Stewart LS, Cortez MA, Snead OC. Environmental enrichment improves behavioral outcome in the AY-9944 model of childhood atypical absence epilepsy. Int J Neurosci. 2012 Aug; 122(8):449-57. PMID: 22471338.
      View in: PubMed
    14. Mirzoev A, Bercovici E, Stewart LS, Cortez MA, Snead OC, Desrocher M. Circadian profiles of focal epileptic seizures: a need for reappraisal. Seizure. 2012 Jul; 21(6):412-6. PMID: 22537415.
      View in: PubMed
    15. Ye L, Zhu W, Backx PH, Cortez MA, Wu J, Chow YH, McKerlie C, Wang A, Tsui LC, Gross GJ, Hu J. Arrhythmia and sudden death associated with elevated cardiac chloride channel activity. J Cell Mol Med. 2011 Nov; 15(11):2307-16. PMID: 21155978; PMCID: PMC3822942.
    16. Kirshenbaum GS, Clapcote SJ, Duffy S, Burgess CR, Petersen J, Jarowek KJ, Yücel YH, Cortez MA, Snead OC, Vilsen B, Peever JH, Ralph MR, Roder JC. Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase a3 sodium pump. Proc Natl Acad Sci U S A. 2011 Nov 01; 108(44):18144-9. PMID: 22025725; PMCID: PMC3207708.
    17. Wu Y, Blichowski M, Daskalakis ZJ, Wu Z, Liu CC, Cortez MA, Snead OC. Evidence that clozapine directly interacts on the GABAB receptor. Neuroreport. 2011 Sep 14; 22(13):637-41. PMID: 21753741.
      View in: PubMed
    18. Stafstrom CE, Arnason BG, Baram TZ, Catania A, Cortez MA, Glauser TA, Pranzatelli MR, Riikonen R, Rogawski MA, Shinnar S, Swann JW. Treatment of infantile spasms: emerging insights from clinical and basic science perspectives. J Child Neurol. 2011 Nov; 26(11):1411-21. PMID: 21719797.
      View in: PubMed
    19. Turnbull J, DePaoli-Roach AA, Zhao X, Cortez MA, Pencea N, Tiberia E, Piliguian M, Roach PJ, Wang P, Ackerley CA, Minassian BA. PTG depletion removes Lafora bodies and rescues the fatal epilepsy of Lafora disease. PLoS Genet. 2011 Apr; 7(4):e1002037. PMID: 21552327; PMCID: PMC3084203.
    20. Menascu S, Mohamed I, Tshechmer SM, Shroff M, Cortez MA. The significance of frontal intermittent rhythmic delta activity in children. Can J Neurol Sci. 2010 Sep; 37(5):656-61. PMID: 21059514.
      View in: PubMed
    21. Poma R, Ochi A, Cortez MA. Absence seizures with myoclonic features in a juvenile Chihuahua dog. Epileptic Disord. 2010 Jun; 12(2):138-41. PMID: 20483714.
      View in: PubMed
    22. Cortez MA, Li C, Whitehead SN, Dhani SU, D'Antonio C, Huan LJ, Bennett SA, Snead OC, Bear CE. Disruption of ClC-2 expression is associated with progressive neurodegeneration in aging mice. Neuroscience. 2010 Apr 28; 167(1):154-62. PMID: 20116415.
      View in: PubMed
    23. Wang X, Stewart L, Cortez MA, Wu Y, Velazquez JL, Liu CC, Shen L, Snead OC. The circuitry of atypical absence seizures in GABA(B)R1a transgenic mice. Pharmacol Biochem Behav. 2009 Nov; 94(1):124-30. PMID: 19666047.
      View in: PubMed
    24. Clapcote SJ, Duffy S, Xie G, Kirshenbaum G, Bechard AR, Rodacker Schack V, Petersen J, Sinai L, Saab BJ, Lerch JP, Minassian BA, Ackerley CA, Sled JG, Cortez MA, Henderson JT, Vilsen B, Roder JC. Mutation I810N in the alpha3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS. Proc Natl Acad Sci U S A. 2009 Aug 18; 106(33):14085-90. PMID: 19666602; PMCID: PMC2729024.
    25. Rafay MF, Cortez MA, de Veber GA, Tan-Dy C, Al-Futaisi A, Yoon W, Fallah S, Moore AM. Predictive value of clinical and EEG features in the diagnosis of stroke and hypoxic ischemic encephalopathy in neonates with seizures. Stroke. 2009 Jul; 40(7):2402-7. PMID: 19478219.
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    26. Cortez MA, Shen L, Wu Y, Aleem IS, Trepanier CH, Sadeghnia HR, Ashraf A, Kanawaty A, Liu CC, Stewart L, Snead OC. Infantile spasms and Down syndrome: a new animal model. Pediatr Res. 2009 May; 65(5):499-503. PMID: 19190545.
      View in: PubMed
    27. Huo JZ, Cortez MA, Snead OC. GABA receptor proteins within lipid rafts in the AY-9944 model of atypical absence seizures. Epilepsia. 2009 Apr; 50(4):776-88. PMID: 19054408.
      View in: PubMed
    28. Ng D, Pitcher GM, Szilard RK, Sertié A, Kanisek M, Clapcote SJ, Lipina T, Kalia LV, Joo D, McKerlie C, Cortez M, Roder JC, Salter MW, McInnes RR. Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. PLoS Biol. 2009 Feb 24; 7(2):e41. PMID: 19243221; PMCID: PMC2652390.
    29. Stewart LS, Wu Y, Eubanks JH, Han H, Leschenko Y, Perez Velazquez JL, Cortez MA, Snead OC. Severity of atypical absence phenotype in GABAB transgenic mice is subunit specific. Epilepsy Behav. 2009 Apr; 14(4):577-81. PMID: 19435582.
      View in: PubMed
    30. Bercovici E, Cortez MA, Wang X, Snead OC. Monoamine variability in the chronic model of atypical absence seizures. Epilepsia. 2009 Apr; 50(4):768-75. PMID: 19054396.
      View in: PubMed
    31. Stewart LS, Nylen KJ, Persinger MA, Cortez MA, Gibson KM, Snead OC. Circadian distribution of generalized tonic-clonic seizures associated with murine succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism. Epilepsy Behav. 2008 Aug; 13(2):290-4. PMID: 18514581; PMCID: PMC2574901.
    32. Sadeghnia HR, Cortez MA, Liu D, Hosseinzadeh H, Snead OC. Antiabsence effects of safranal in acute experimental seizure models: EEG and autoradiography. J Pharm Pharm Sci. 2008; 11(3):1-14. PMID: 18801302.
      View in: PubMed
    33. Nylen K, Velazquez JL, Likhodii SS, Cortez MA, Shen L, Leshchenko Y, Adeli K, Gibson KM, Burnham WM, Snead OC. A ketogenic diet rescues the murine succinic semialdehyde dehydrogenase deficient phenotype. Exp Neurol. 2008 Apr; 210(2):449-57. PMID: 18199435; PMCID: PMC2362105.
    34. Bercovici E, Cortez MA, Snead OC. 5-HT2 modulation of AY-9944 induced atypical absence seizures. Neurosci Lett. 2007 May 11; 418(1):13-7. PMID: 17350760.
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    35. Wu Y, Chan KF, Eubanks JH, Guin Ting Wong C, Cortez MA, Shen L, Che Liu C, Perez Velazquez J, Tian Wang Y, Jia Z, Carter Snead O. Transgenic mice over-expressing GABA(B)R1a receptors acquire an atypical absence epilepsy-like phenotype. Neurobiol Dis. 2007 May; 26(2):439-51. PMID: 17363260.
      View in: PubMed
    36. Stewart LS, Persinger MA, Cortez MA, Snead OC. Chronobiometry of behavioral activity in the Ts65Dn model of Down syndrome. Behav Genet. 2007 Mar; 37(2):388-98. PMID: 17146725.
      View in: PubMed
    37. Stewart LS, Bercovici E, Shukla R, Serbanescu I, Persad V, Mistry N, Cortez MA, Snead OC. Daily rhythms of seizure activity and behavior in a model of atypical absence epilepsy. Epilepsy Behav. 2006 Dec; 9(4):564-72. PMID: 17030024.
      View in: PubMed
    38. Saengpattrachai M, Sharma R, Hunjan A, Shroff M, Ochi A, Otsubo H, Cortez MA, Carter Snead O. Nonconvulsive seizures in the pediatric intensive care unit: etiology, EEG, and brain imaging findings. Epilepsia. 2006 Sep; 47(9):1510-8. PMID: 16981868.
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    39. Buzzi A, Wu Y, Frantseva MV, Perez Velazquez JL, Cortez MA, Liu CC, Shen LQ, Gibson KM, Snead OC. Succinic semialdehyde dehydrogenase deficiency: GABAB receptor-mediated function. Brain Res. 2006 May 23; 1090(1):15-22. PMID: 16647690.
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    40. Chan KF, Burnham WM, Jia Z, Cortez MA, Snead OC. GABAB receptor antagonism abolishes the learning impairments in rats with chronic atypical absence seizures. Eur J Pharmacol. 2006 Jul 10; 541(1-2):64-72. PMID: 16762340.
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    41. Bercovici E, Cortez MA, Wang X, Snead OC. Serotonin depletion attenuates AY-9944-mediated atypical absence seizures. Epilepsia. 2006 Feb; 47(2):240-6. PMID: 16499747.
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    42. Cortez MA, Perez Velazquez JL, Snead OC. Animal models of epilepsy and progressive effects of seizures. Adv Neurol. 2006; 97:293-304. PMID: 16383138.
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    43. Wu Y, Buzzi A, Frantseva M, Velazquez JP, Cortez M, Liu C, Shen L, Gibson KM, Snead OC. Status epilepticus in mice deficient for succinate semialdehyde dehydrogenase: GABAA receptor-mediated mechanisms. Ann Neurol. 2006 Jan; 59(1):42-52. PMID: 16240371.
      View in: PubMed
    44. Ramachandrannair R, Sharma R, Weiss SK, Cortez MA. Reactive EEG patterns in pediatric coma. Pediatr Neurol. 2005 Nov; 33(5):345-9. PMID: 16243222.
      View in: PubMed
    45. RamachandranNair R, Sharma R, Weiss SK, Otsubo H, Cortez MA. A reappraisal of rhythmic coma patterns in children. Can J Neurol Sci. 2005 Nov; 32(4):518-23. PMID: 16408585.
      View in: PubMed
    46. Nolan M, Bergazar M, Chu B, Cortez MA, Snead OC. Clinical and neurophysiologic spectrum associated with atypical absence seizures in children with intractable epilepsy. J Child Neurol. 2005 May; 20(5):404-10. PMID: 15968924.
      View in: PubMed
    47. Chan KF, Jia Z, Murphy PA, Burnham WM, Cortez MA, Snead OC. Learning and memory impairment in rats with chronic atypical absence seizures. Exp Neurol. 2004 Dec; 190(2):328-36. PMID: 15530872.
      View in: PubMed
    48. Serbanescu I, Cortez MA, McKerlie C, Snead OC. Refractory atypical absence seizures in rat: a two hit model. Epilepsy Res. 2004 Nov; 62(1):53-63. PMID: 15519132.
      View in: PubMed
    49. Cortez MA, Wu Y, Gibson KM, Snead OC. Absence seizures in succinic semialdehyde dehydrogenase deficient mice: a model of juvenile absence epilepsy. Pharmacol Biochem Behav. 2004 Nov; 79(3):547-53. PMID: 15582027.
      View in: PubMed
    50. Serbanescu I, Ryan MA, Shukla R, Cortez MA, Snead OC, Cunnane SC. Lovastatin exacerbates atypical absence seizures with only minimal effects on brain sterols. J Lipid Res. 2004 Nov; 45(11):2038-43. PMID: 15314096.
      View in: PubMed
    51. Chan EM, Ackerley CA, Lohi H, Ianzano L, Cortez MA, Shannon P, Scherer SW, Minassian BA. Laforin preferentially binds the neurotoxic starch-like polyglucosans, which form in its absence in progressive myoclonus epilepsy. Hum Mol Genet. 2004 Jun 01; 13(11):1117-29. PMID: 15102711.
      View in: PubMed
    52. Persad V, Ting Wong CG, Cortez MA, Wang YT, Snead OC. Hormonal regulation of atypical absence seizures. Ann Neurol. 2004 Mar; 55(3):353-61. PMID: 14991813.
      View in: PubMed
    53. Likhodii SS, Serbanescu I, Cortez MA, Murphy P, Snead OC, Burnham WM. Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet. Ann Neurol. 2003 Aug; 54(2):219-26. PMID: 12891674.
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    54. Persad V, Cortez MA, Snead OC. A chronic model of atypical absence seizures: studies of developmental and gender sensitivity. Epilepsy Res. 2002 Jan; 48(1-2):111-9. PMID: 11823115.
      View in: PubMed
    55. Cortez MA, Cunnane SC, Snead OC. Brain sterols in the AY-9944 rat model of atypical absence seizures. Epilepsia. 2002 Jan; 43(1):3-8. PMID: 11879380.
      View in: PubMed
    56. Hu RQ, Cortez MA, Man HY, Roder J, Jia Z, Wang YT, Snead OC. Gamma-hydroxybutyric acid-induced absence seizures in GluR2 null mutant mice. Brain Res. 2001 Apr 06; 897(1-2):27-35. PMID: 11282355.
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    57. Hu RQ, Cortez MA, Man HY, Wang YT, Snead OC. Alteration of GLUR2 expression in the rat brain following absence seizures induced by gamma-hydroxybutyric acid. Epilepsy Res. 2001 Apr; 44(1):41-51. PMID: 11255072.
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    58. Winer S, Astsaturov I, Cheung R, Gunaratnam L, Kubiak V, Cortez MA, Moscarello M, O'Connor PW, McKerlie C, Becker DJ, Dosch HM. Type I diabetes and multiple sclerosis patients target islet plus central nervous system autoantigens; nonimmunized nonobese diabetic mice can develop autoimmune encephalitis. J Immunol. 2001 Feb 15; 166(4):2831-41. PMID: 11160351.
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    59. Cortez MA, McKerlie C, Snead OC. A model of atypical absence seizures: EEG, pharmacology, and developmental characterization. Neurology. 2001 Feb 13; 56(3):341-9. PMID: 11171899.
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    60. Balslev T, Cortez MA, Blaser SI, Haslam RH. Recurrent seizures in metachromatic leukodystrophy. Pediatr Neurol. 1997 Sep; 17(2):150-4. PMID: 9367296.
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    61. Cortez MA, Burnham WM, Hwang PA. Infantile spasms: seasonal onset differences and zeitgebers. Pediatr Neurol. 1997 Apr; 16(3):220-4. PMID: 9165513.
      View in: PubMed
    62. Theis JG, Koren G, Daneman R, Sherwin AL, Menzano E, Cortez M, Hwang P. Interactions of clobazam with conventional antiepileptics in children. J Child Neurol. 1997 Apr; 12(3):208-13. PMID: 9130097.
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    63. Jay V, Becker LE, Otsubo H, Cortez M, Hwang P, Hoffman HJ, Zielenska M. Chronic encephalitis and epilepsy (Rasmussen's encephalitis): detection of cytomegalovirus and herpes simplex virus 1 by the polymerase chain reaction and in situ hybridization. Neurology. 1995 Jan; 45(1):108-17. PMID: 7824098.
      View in: PubMed
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