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Fred Keeley

TitleScientist Emeritus
InstitutionThe Hospital for Sick Children
DepartmentMolecular Medicine
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Muiznieks LD, Sharpe S, Pomès R, Keeley FW. Role of Liquid-Liquid Phase Separation in Assembly of Elastin and Other Extracellular Matrix Proteins. J Mol Biol. 2018 Nov 02; 430(23):4741-4753. PMID: 29886015.
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    2. Reuter MS, Walker S, Thiruvahindrapuram B, Whitney J, Cohn I, Sondheimer N, Yuen RKC, Trost B, Paton TA, Pereira SL, Herbrick JA, Wintle RF, Merico D, Howe J, MacDonald JR, Lu C, Nalpathamkalam T, Sung WWL, Wang Z, Patel RV, Pellecchia G, Wei J, Strug LJ, Bell S, Kellam B, Mahtani MM, Bassett AS, Bombard Y, Weksberg R, Shuman C, Cohn RD, Stavropoulos DJ, Bowdin S, Hildebrandt MR, Wei W, Romm A, Pasceri P, Ellis J, Ray P, Meyn MS, Monfared N, Hosseini SM, Joseph-George AM, Keeley FW, Cook RA, Fiume M, Lee HC, Marshall CR, Davies J, Hazell A, Buchanan JA, Szego MJ, Scherer SW. The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants. CMAJ. 2018 02 05; 190(5):E126-E136. PMID: 29431110.
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    3. Reichheld SE, Muiznieks LD, Keeley FW, Sharpe S. Direct observation of structure and dynamics during phase separation of an elastomeric protein. Proc Natl Acad Sci U S A. 2017 05 30; 114(22):E4408-E4415. PMID: 28507126.
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    4. Miao M, Reichheld SE, Muiznieks LD, Sitarz EE, Sharpe S, Keeley FW. Single nucleotide polymorphisms and domain/splice variants modulate assembly and elastomeric properties of human elastin. Implications for tissue specificity and durability of elastic tissue. Biopolymers. 2017 May; 107(5). PMID: 27997981.
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    5. Muiznieks LD, Keeley FW. Phase separation and mechanical properties of an elastomeric biomaterial from spider wrapping silk and elastin block copolymers. Biopolymers. 2016 Oct; 105(10):693-703. PMID: 27272259.
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    6. Muiznieks LD, Miao M, Sitarz EE, Keeley FW. Contribution of domain 30 of tropoelastin to elastic fiber formation and material elasticity. Biopolymers. 2016 May; 105(5):267-75. PMID: 26763595.
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    7. Moriyama Y, Ito F, Takeda H, Yano T, Okabe M, Kuraku S, Keeley FW, Koshiba-Takeuchi K. Evolution of the fish heart by sub/neofunctionalization of an elastin gene. Nat Commun. 2016 Jan 19; 7:10397. PMID: 26783159.
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    8. Muiznieks LD, Reichheld SE, Sitarz EE, Miao M, Keeley FW. Proline-poor hydrophobic domains modulate the assembly and material properties of polymeric elastin. Biopolymers. 2015 Oct; 103(10):563-73. PMID: 25924982.
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    9. Heinz A, Schräder CU, Baud S, Keeley FW, Mithieux SM, Weiss AS, Neubert RH, Schmelzer CE. Molecular-level characterization of elastin-like constructs and human aortic elastin. Matrix Biol. 2014 Sep; 38:12-21. PMID: 25068896.
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    10. Muiznieks LD, Cirulis JT, van der Horst A, Reinhardt DP, Wuite GJ, Pomès R, Keeley FW. Modulated growth, stability and interactions of liquid-like coacervate assemblies of elastin. Matrix Biol. 2014 Jun; 36:39-50. PMID: 24727034.
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    11. Reichheld SE, Muiznieks LD, Stahl R, Simonetti K, Sharpe S, Keeley FW. Conformational transitions of the cross-linking domains of elastin during self-assembly. J Biol Chem. 2014 Apr 04; 289(14):10057-68. PMID: 24550393.
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    12. Miao M, Reichheld SE, Muiznieks LD, Huang Y, Keeley FW. Elastin binding protein and FKBP65 modulate in vitro self-assembly of human tropoelastin. Biochemistry. 2013 Nov 05; 52(44):7731-41. PMID: 24106871.
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    13. Miao M, Sitarz E, Bellingham CM, Won E, Muiznieks LD, Keeley FW. Sequence and domain arrangements influence mechanical properties of elastin-like polymeric elastomers. Biopolymers. 2013 Jun; 99(6):392-407. PMID: 23529691.
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    14. Heinz A, Ruttkies CK, Jahreis G, Schräder CU, Wichapong K, Sippl W, Keeley FW, Neubert RH, Schmelzer CE. In vitro cross-linking of elastin peptides and molecular characterization of the resultant biomaterials. Biochim Biophys Acta. 2013 Apr; 1830(4):2994-3004. PMID: 23375722.
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    15. Muiznieks LD, Keeley FW. Molecular assembly and mechanical properties of the extracellular matrix: A fibrous protein perspective. Biochim Biophys Acta. 2013 Jul; 1832(7):866-75. PMID: 23220448.
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    16. He D, Miao M, Sitarz EE, Muiznieks LD, Reichheld S, Stahl RJ, Keeley FW, Parkinson J. Polymorphisms in the human tropoelastin gene modify in vitro self-assembly and mechanical properties of elastin-like polypeptides. PLoS One. 2012; 7(9):e46130. PMID: 23049958.
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    17. Yeo GC, Keeley FW, Weiss AS. Coacervation of tropoelastin. Adv Colloid Interface Sci. 2011 Sep 14; 167(1-2):94-103. PMID: 21081222.
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    18. Muiznieks LD, Keeley FW. Proline periodicity modulates the self-assembly properties of elastin-like polypeptides. J Biol Chem. 2010 Dec 17; 285(51):39779-89. PMID: 20947499.
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    19. Akhtar K, Broekelmann TJ, Miao M, Keeley FW, Starcher BC, Pierce RA, Mecham RP, Adair-Kirk TL. Oxidative and nitrosative modifications of tropoelastin prevent elastic fiber assembly in vitro. J Biol Chem. 2010 Nov 26; 285(48):37396-404. PMID: 20847053.
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    20. Cirulis JT, Keeley FW. Kinetics and morphology of self-assembly of an elastin-like polypeptide based on the alternating domain arrangement of human tropoelastin. Biochemistry. 2010 Jul 13; 49(27):5726-33. PMID: 20527981.
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    21. Sarkola T, Redington A, Keeley F, Bradley T, Jaeggi E. Transcutaneous very-high-resolution ultrasound to quantify arterial wall layers of muscular and elastic arteries: validation of a method. Atherosclerosis. 2010 Oct; 212(2):516-23. PMID: 20673898.
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    22. Muiznieks LD, Weiss AS, Keeley FW. Structural disorder and dynamics of elastin. Biochem Cell Biol. 2010 Apr; 88(2):239-50. PMID: 20453927.
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    23. Hrabchak C, Rouleau J, Moss I, Woodhouse K, Akens M, Bellingham C, Keeley F, Dennis M, Yee A. Assessment of biocompatibility and initial evaluation of genipin cross-linked elastin-like polypeptides in the treatment of an osteochondral knee defect in rabbits. Acta Biomater. 2010 Jun; 6(6):2108-15. PMID: 20026437.
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    24. Hubmacher D, Cirulis JT, Miao M, Keeley FW, Reinhardt DP. Functional consequences of homocysteinylation of the elastic fiber proteins fibrillin-1 and tropoelastin. J Biol Chem. 2010 Jan 08; 285(2):1188-98. PMID: 19889633.
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    25. Miao M, Stahl RJ, Petersen LF, Reintsch WE, Davis EC, Keeley FW. Characterization of an unusual tropoelastin with truncated C-terminus in the frog. Matrix Biol. 2009 Sep; 28(7):432-41. PMID: 19638308.
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    26. Cirulis JT, Bellingham CM, Davis EC, Hubmacher D, Reinhardt DP, Mecham RP, Keeley FW. Fibrillins, fibulins, and matrix-associated glycoprotein modulate the kinetics and morphology of in vitro self-assembly of a recombinant elastin-like polypeptide. Biochemistry. 2008 Nov 25; 47(47):12601-13. PMID: 18973305.
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    27. Sirianni RW, Kremer J, Guler I, Chen YL, Keeley FW, Saltzman WM. Effect of extracellular matrix elements on the transport of paclitaxel through an arterial wall tissue mimic. Biomacromolecules. 2008 Oct; 9(10):2792-8. PMID: 18785771.
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    28. Hill CH, Ashwell CM, Nolin SJ, Keeley F, Billingham C, Hinek A, Starcher B. Dietary iron deficiency compromises normal development of elastic fibers in the aorta and lungs of chicks. J Nutr. 2007 Aug; 137(8):1895-900. PMID: 17634261.
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    29. He D, Chung M, Chan E, Alleyne T, Ha KC, Miao M, Stahl RJ, Keeley FW, Parkinson J. Comparative genomics of elastin: Sequence analysis of a highly repetitive protein. Matrix Biol. 2007 Sep; 26(7):524-40. PMID: 17628459.
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    30. Vieth S, Bellingham CM, Keeley FW, Hodge SM, Rousseau D. Microstructural and tensile properties of elastin-based polypeptides crosslinked with genipin and pyrroloquinoline quinone. Biopolymers. 2007 Feb 15; 85(3):199-206. PMID: 17066474.
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    31. Rauscher S, Baud S, Miao M, Keeley FW, Pomès R. Proline and glycine control protein self-organization into elastomeric or amyloid fibrils. Structure. 2006 Nov; 14(11):1667-76. PMID: 17098192.
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    32. Miao M, Bruce AE, Bhanji T, Davis EC, Keeley FW. Differential expression of two tropoelastin genes in zebrafish. Matrix Biol. 2007 Mar; 26(2):115-24. PMID: 17112714.
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    33. Chung MI, Miao M, Stahl RJ, Chan E, Parkinson J, Keeley FW. Sequences and domain structures of mammalian, avian, amphibian and teleost tropoelastins: Clues to the evolutionary history of elastins. Matrix Biol. 2006 Oct; 25(8):492-504. PMID: 16982180.
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    34. Kumashiro KK, Ho JP, Niemczura WP, Keeley FW. Cooperativity between the hydrophobic and cross-linking domains of elastin. J Biol Chem. 2006 Aug 18; 281(33):23757-65. PMID: 16777851.
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    35. Youson JH, Heinig JA, Khanam SF, Sower SA, Kawauchi H, Keeley FW. Patterns of proopiomelanotropin and proopiocortin gene expression and of immunohistochemistry for gonadotropin-releasing hormones (lGnRH-I and III) during the life cycle of a nonparasitic lamprey: relationship to this adult life history type. Gen Comp Endocrinol. 2006 Aug; 148(1):54-71. PMID: 16364323.
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    36. Miao M, Cirulis JT, Lee S, Keeley FW. Structural determinants of cross-linking and hydrophobic domains for self-assembly of elastin-like polypeptides. Biochemistry. 2005 Nov 01; 44(43):14367-75. PMID: 16245953.
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    37. Broekelmann TJ, Kozel BA, Ishibashi H, Werneck CC, Keeley FW, Zhang L, Mecham RP. Tropoelastin interacts with cell-surface glycosaminoglycans via its COOH-terminal domain. J Biol Chem. 2005 Dec 09; 280(49):40939-47. PMID: 16192266.
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    38. Woodhouse KA, Klement P, Chen V, Gorbet MB, Keeley FW, Stahl R, Fromstein JD, Bellingham CM. Investigation of recombinant human elastin polypeptides as non-thrombogenic coatings. Biomaterials. 2004 Aug; 25(19):4543-53. PMID: 15120499.
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    39. Bellingham CM, Lillie MA, Gosline JM, Wright GM, Starcher BC, Bailey AJ, Woodhouse KA, Keeley FW. Recombinant human elastin polypeptides self-assemble into biomaterials with elastin-like properties. Biopolymers. 2003 Dec; 70(4):445-55. PMID: 14648756.
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    40. Miao M, Bellingham CM, Stahl RJ, Sitarz EE, Lane CJ, Keeley FW. Sequence and structure determinants for the self-aggregation of recombinant polypeptides modeled after human elastin. J Biol Chem. 2003 Dec 05; 278(49):48553-62. PMID: 14500713.
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    41. Visconti RP, Barth JL, Keeley FW, Little CD. Codistribution analysis of elastin and related fibrillar proteins in early vertebrate development. Matrix Biol. 2003 Apr; 22(2):109-21. PMID: 12782138.
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    42. Keeley FW, Bellingham CM, Woodhouse KA. Elastin as a self-organizing biomaterial: use of recombinantly expressed human elastin polypeptides as a model for investigations of structure and self-assembly of elastin. Philos Trans R Soc Lond B Biol Sci. 2002 Feb 28; 357(1418):185-9. PMID: 11911775.
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    43. Bellingham CM, Woodhouse KA, Robson P, Rothstein SJ, Keeley FW. Self-aggregation characteristics of recombinantly expressed human elastin polypeptides. Biochim Biophys Acta. 2001 Nov 26; 1550(1):6-19. PMID: 11738083.
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    44. Wright GM, Keeley FW, Robson P. The unusual cartilaginous tissues of jawless craniates, cephalochordates and invertebrates. Cell Tissue Res. 2001 May; 304(2):165-74. PMID: 11396711.
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    45. Robson P, Wright GM, Youson JH, Keeley FW. The structure and organization of lamprin genes: multiple-copy genes with alternative splicing and convergent evolution with insect structural proteins. Mol Biol Evol. 2000 Nov; 17(11):1739-52. PMID: 11070061.
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    46. Robson P, Wright GM, Keeley FW. Distinct non-collagen based cartilages comprising the endoskeleton of the Atlantic hagfish, Myxine glutinosa. Anat Embryol (Berl). 2000 Oct; 202(4):281-90. PMID: 11000279.
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    47. Hornberger LK, Singhroy S, Cavalle-Garrido T, Tsang W, Keeley F, Rabinovitch M. Synthesis of extracellular matrix and adhesion through beta(1) integrins are critical for fetal ventricular myocyte proliferation. Circ Res. 2000 Sep 15; 87(6):508-15. PMID: 10988244.
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    48. Hew Y, Lau C, Grzelczak Z, Keeley FW. Identification of a GA-rich sequence as a protein-binding site in the 3'-untranslated region of chicken elastin mRNA with a potential role in the developmental regulation of elastin mRNA stability. J Biol Chem. 2000 Aug 11; 275(32):24857-64. PMID: 10829024.
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    49. Hew Y, Grzelczak Z, Lau C, Keeley FW. Identification of a large region of secondary structure in the 3'-untranslated region of chicken elastin mRNA with implications for the regulation of mRNA stability. J Biol Chem. 1999 May 14; 274(20):14415-21. PMID: 10318866.
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    50. Filosa MF, Adam I, Robson P, Heinig JA, Smith K, Keeley FW, Youson JH. Partial clone of the gene for AS protein of the lamprey Petromyzon marinus, a member of the albumin supergene family whose expression is restricted to the larval and metamorphic phases of the life cycle. J Exp Zool. 1998 Oct 15; 282(3):301-9. PMID: 9755481.
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    51. Robson P, Li F, Youson JH, Keeley FW. Identification and characterization of a serpin with differential expression during the life cycle of the sea lamprey. Comp Biochem Physiol B Biochem Mol Biol. 1998 Jun; 120(2):253-63. PMID: 9787795.
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    52. Tsoporis J, Keeley FW, Lee RM, Leenen FH. Arterial vasodilation and vascular connective tissue changes in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1998 Jun; 31(6):960-2. PMID: 9641483.
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    53. Ficele G, Heinig JA, Kawauchi H, Youson JH, Keeley FW, Wright GM. Spatial and temporal distribution of proopiomelanotropin and proopiocortin mRNA during the life cycle of the sea lamprey: a qualitative and quantitative in situ hybridization study. Gen Comp Endocrinol. 1998 May; 110(2):212-25. PMID: 9570942.
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    54. Strauss BH, Robinson R, Batchelor WB, Chisholm RJ, Ravi G, Natarajan MK, Logan RA, Mehta SR, Levy DE, Ezrin AM, Keeley FW. In vivo collagen turnover following experimental balloon angioplasty injury and the role of matrix metalloproteinases. Circ Res. 1996 Sep; 79(3):541-50. PMID: 8781487.
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    55. McBurney KM, Keeley FW, Kibenge FS, Wright GM. Spatial and temporal distribution of lamprin mRNA during chondrogenesis of trabecular cartilage in the sea lamprey. Anat Embryol (Berl). 1996 May; 193(5):419-26. PMID: 8729960.
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    56. McBurney KM, Keeley FW, Kibenge FS, Wrignt GM. Detection of lamprin mRNA in the anadromous sea lamprey using in situ hybridization. Biotech Histochem. 1996 Jan; 71(1):44-53. PMID: 9138528.
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    57. Johnson DJ, Robson P, Hew Y, Keeley FW. Decreased elastin synthesis in normal development and in long-term aortic organ and cell cultures is related to rapid and selective destabilization of mRNA for elastin. Circ Res. 1995 Dec; 77(6):1107-13. PMID: 7586222.
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    58. Hinek A, Keeley FW, Callahan J. Recycling of the 67-kDa elastin binding protein in arterial myocytes is imperative for secretion of tropoelastin. Exp Cell Res. 1995 Oct; 220(2):312-24. PMID: 7556439.
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    59. Heinig JA, Keeley FW, Robson P, Sower SA, Youson JH. The appearance of proopiomelanocortin early in vertebrate evolution: cloning and sequencing of POMC from a Lamprey pituitary cDNA library. Gen Comp Endocrinol. 1995 Aug; 99(2):137-44. PMID: 8536922.
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    60. Keeley FW, Bartoszewicz LA. Elastin in systemic and pulmonary hypertension. Ciba Found Symp. 1995; 192:259-73; discussion 273-8. PMID: 8575261.
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    61. Bendeck MP, Keeley FW, Langille BL. Perinatal accumulation of arterial wall constituents: relation to hemodynamic changes at birth. Am J Physiol. 1994 Dec; 267(6 Pt 2):H2268-79. PMID: 7810727.
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    62. Strauss BH, Chisholm RJ, Keeley FW, Gotlieb AI, Logan RA, Armstrong PW. Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis. Circ Res. 1994 Oct; 75(4):650-8. PMID: 7923611.
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    63. Ruzicka M, Keeley FW, Leenen FH. The renin-angiotensin system and volume overload-induced changes in cardiac collagen and elastin. Circulation. 1994 Oct; 90(4):1989-96. PMID: 7923689.
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    64. Zhu L, Wigle D, Hinek A, Kobayashi J, Ye C, Zuker M, Dodo H, Keeley FW, Rabinovitch M. The endogenous vascular elastase that governs development and progression of monocrotaline-induced pulmonary hypertension in rats is a novel enzyme related to the serine proteinase adipsin. J Clin Invest. 1994 Sep; 94(3):1163-71. PMID: 8083356.
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    65. Kobayashi J, Wigle D, Childs T, Zhu L, Keeley FW, Rabinovitch M. Serum-induced vascular smooth muscle cell elastolytic activity through tyrosine kinase intracellular signalling. J Cell Physiol. 1994 Jul; 160(1):121-31. PMID: 8021292.
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    66. Belik J, Keeley FW, Baldwin F, Rabinovitch M. Pulmonary hypertension and vascular remodeling in fetal sheep. Am J Physiol. 1994 Jun; 266(6 Pt 2):H2303-9. PMID: 8023991.
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    67. Kreder HJ, Moran M, Keeley FW, Salter RB. Biologic resurfacing of a major joint defect with cryopreserved allogeneic periosteum under the influence of continuous passive motion in a rabbit model. Clin Orthop Relat Res. 1994 Mar; (300):288-96. PMID: 8131351.
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    68. Wells MD, Posnick JC, Goldstein J, Slate RK, Keeley FW, Thorner PS. Fetal bone gap healing in utero. J Oral Maxillofac Surg. 1993 Nov; 51(11):1235-42; discussion 1243. PMID: 8229396.
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    69. Slate RK, Posnick JC, Wells MD, Goldstein JA, Keeley FW, Thorner PS. Fetal tibial bone healing in utero: the effects of miniplate fixation. Plast Reconstr Surg. 1993 Oct; 92(5):874-83. PMID: 8415969.
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    70. Kreder HJ, Keeley FW, Salter R. Cryopreservation of periosteum for transplantation. Cryobiology. 1993 Apr; 30(2):107-15. PMID: 8319481.
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    71. Hinek A, Rabinovitch M, Keeley F, Okamura-Oho Y, Callahan J. The 67-kD elastin/laminin-binding protein is related to an enzymatically inactive, alternatively spliced form of beta-galactosidase. J Clin Invest. 1993 Mar; 91(3):1198-205. PMID: 8383699.
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    72. Zhu L, Dagher E, Johnson DJ, Bedell-Hogan D, Keeley FW, Kagan HM, Rabinovitch M. A developmentally regulated program restricting insolubilization of elastin and formation of laminae in the fetal lamb ductus arteriosus. Lab Invest. 1993 Mar; 68(3):321-31. PMID: 8095564.
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    73. Robson P, Wright GM, Sitarz E, Maiti A, Rawat M, Youson JH, Keeley FW. Characterization of lamprin, an unusual matrix protein from lamprey cartilage. Implications for evolution, structure, and assembly of elastin and other fibrillar proteins. J Biol Chem. 1993 Jan 15; 268(2):1440-7. PMID: 7678258.
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    74. Johnson DJ, LaBourene J, Rabinovitch M, Keeley FW. Relative efficiency of incorporation of newly synthesized elastin and collagen into aorta, pulmonary artery and pulmonary vein of growing pigs. Connect Tissue Res. 1993; 29(3):213-21. PMID: 8222648.
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    75. Todorovich-Hunter L, Dodo H, Ye C, McCready L, Keeley FW, Rabinovitch M. Increased pulmonary artery elastolytic activity in adult rats with monocrotaline-induced progressive hypertensive pulmonary vascular disease compared with infant rats with nonprogressive disease. Am Rev Respir Dis. 1992 Jul; 146(1):213-23. PMID: 1626806.
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    76. Keeley FW, Elmoselhi A, Leenen FH. Enalapril suppresses normal accumulation of elastin and collagen in cardiovascular tissues of growing rats. Am J Physiol. 1992 Apr; 262(4 Pt 2):H1013-21. PMID: 1566884.
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    77. Hinek A, Mecham RP, Keeley F, Rabinovitch M. Impaired elastin fiber assembly related to reduced 67-kD elastin-binding protein in fetal lamb ductus arteriosus and in cultured aortic smooth muscle cells treated with chondroitin sulfate. J Clin Invest. 1991 Dec; 88(6):2083-94. PMID: 1661296.
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    78. Keeley FW, Alatawi A. Response of aortic elastin synthesis and accumulation to developing hypertension and the inhibitory effect of colchicine on this response. Lab Invest. 1991 Apr; 64(4):499-507. PMID: 2016856.
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    79. Vachon AM, McIlwraith CW, Keeley FW. Biochemical study of repair of induced osteochondral defects of the distal portion of the radial carpal bone in horses by use of periosteal autografts. Am J Vet Res. 1991 Feb; 52(2):328-32. PMID: 2012345.
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    80. Keeley FW, Elmoselhi A, Leenen FH. Effects of antihypertensive drug classes on regression of connective tissue components of hypertension. J Cardiovasc Pharmacol. 1991; 17 Suppl 2:S64-9. PMID: 1715488.
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    81. Keeley FW, Hussain RA, Johnson DJ. Pattern of accumulation of elastin and the level of mRNA for elastin in aortic tissue of growing chickens. Arch Biochem Biophys. 1990 Nov 01; 282(2):226-32. PMID: 2241145.
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    82. Soucy P, Eidus L, Keeley F. Perforation of the colon in a 15-year-old girl with Ehlers-Danlos syndrome type IV. J Pediatr Surg. 1990 Nov; 25(11):1180-2. PMID: 2273436.
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    83. Byard RW, Keeley FW, Smith CR. Type IV Ehlers-Danlos syndrome presenting as sudden infant death. Am J Clin Pathol. 1990 Apr; 93(4):579-82. PMID: 2321591.
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    84. LaBourene JI, Coles JG, Johnson DJ, Mehra A, Keeley FW, Rabinovitch M. Alterations in elastin and collagen related to the mechanism of progressive pulmonary venous obstruction in a piglet model. A hemodynamic, ultrastructural, and biochemical study. Circ Res. 1990 Feb; 66(2):438-56. PMID: 2297812.
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    85. Johnson DJ, Keeley FW. Factors affecting the production of insoluble elastin in aortic organ cultures. Connect Tissue Res. 1990; 24(3-4):277-88. PMID: 2376129.
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    86. Langille BL, Bendeck MP, Keeley FW. Adaptations of carotid arteries of young and mature rabbits to reduced carotid blood flow. Am J Physiol. 1989 Apr; 256(4 Pt 2):H931-9. PMID: 2705563.
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    87. Hardy MH, Fisher KR, Vrablic OE, Yager JA, Nimmo-Wilkie JS, Parker W, Keeley FW. An inherited connective tissue disease in the horse. Lab Invest. 1988 Aug; 59(2):253-62. PMID: 3404977.
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    88. O'Driscoll SW, Keeley FW, Salter RB. Durability of regenerated articular cartilage produced by free autogenous periosteal grafts in major full-thickness defects in joint surfaces under the influence of continuous passive motion. A follow-up report at one year. J Bone Joint Surg Am. 1988 Apr; 70(4):595-606. PMID: 3356727.
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    89. Todorovich-Hunter L, Johnson DJ, Ranger P, Keeley FW, Rabinovitch M. Altered elastin and collagen synthesis associated with progressive pulmonary hypertension induced by monocrotaline. A biochemical and ultrastructural study. Lab Invest. 1988 Feb; 58(2):184-95. PMID: 3123799.
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    90. Keeley FW, Johnson DJ. Age differences in the effect of hydrocortisone on the synthesis of insoluble elastin in aortic tissue of growing chicks. Connect Tissue Res. 1987; 16(3):259-68. PMID: 2956052.
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    91. O'Driscoll SW, Keeley FW, Salter RB. The chondrogenic potential of free autogenous periosteal grafts for biological resurfacing of major full-thickness defects in joint surfaces under the influence of continuous passive motion. An experimental investigation in the rabbit. J Bone Joint Surg Am. 1986 Sep; 68(7):1017-35. PMID: 3745239.
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    92. Keeley FW, Johnson DJ. The effect of developing hypertension on the synthesis and accumulation of elastin in the aorta of the rat. Biochem Cell Biol. 1986 Jan; 64(1):38-43. PMID: 3964464.
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    93. Keeley FW, Sitarz EE. Identification and quantitation of alpha 2-HS-glycoprotein in the mineralized matrix of calcified plaques of atherosclerotic human aorta. Atherosclerosis. 1985 Apr; 55(1):63-9. PMID: 3924066.
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    94. O'Driscoll SW, Salter RB, Keeley FW. A method for quantitative analysis of ratios of types I and II collagen in small samples of articular cartilage. Anal Biochem. 1985 Mar; 145(2):277-85. PMID: 4014660.
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    95. Keeley FW, Johnson DJ. The effect of induced atherosclerosis on the synthesis of elastin in chick aortic tissue. Atherosclerosis. 1985 Mar; 54(3):311-9. PMID: 2986656.
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    96. Gillan JE, Costigan DC, Keeley FW, Rose T, Cutz E, Rose V. Spontaneous dissecting aneurysm of the ductus arteriosus in an infant with Marfan syndrome. J Pediatr. 1984 Dec; 105(6):952-5. PMID: 6502348.
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    97. Wright GM, Keeley FW, Youson JH, Babineau DL. Cartilage in the Atlantic hagfish, Myxine glutinosa. Am J Anat. 1984 Apr; 169(4):407-24. PMID: 6731333.
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    98. Keeley FW, Johnson DJ. Measurement of the absolute synthesis of soluble and insoluble elastin by chick aortic tissue. Can J Biochem Cell Biol. 1983 Oct; 61(10):1079-84. PMID: 6652559.
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    99. Keeley FW, Sitarz EE. Characterization of proteins from the calcified matrix of atherosclerotic human aorta. Atherosclerosis. 1983 Jan; 46(1):29-40. PMID: 6340702.
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    100. Salter RB, Bell RS, Keeley FW. The protective effect of continuous passive motion in living articular cartilage in acute septic arthritis: an experimental investigation in the rabbit. Clin Orthop Relat Res. 1981 Sep; (159):223-47. PMID: 7285461.
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    101. Keeley FW. Identification of elastin in developing aortic tissue by immunological methods. Connect Tissue Res. 1981; 8(3-4):193-8. PMID: 6455246.
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    102. Rooker GD, Steins GN, Tate LJ, Keeley FW. Biochemical identification of elastin in periosteum and pericranium. Clin Orthop Relat Res. 1980 Oct; (152):292-5. PMID: 7438619.
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    103. Johnson RG, Stollery J, Keeley FW, Herbert MA. Biochemical analysis of rabbit articular cartilage using an amino acid analyzer. Clin Orthop Relat Res. 1980 Jan-Feb; (146):282-8. PMID: 6768486.
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    104. Keeley FW. The synthesis of soluble and insoluble elastin in chicken aorta as a function of development and age. Effect of a high cholesterol diet. Can J Biochem. 1979 Nov; 57(11):1273-80. PMID: 540239.
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    105. Keeley FW, Fagan DG, Webster SI. Quantity and character of elastin in developing human lung parenchymal tissues of normal infants and infants with respiratory distress syndrome. J Lab Clin Med. 1977 Dec; 90(6):981-9. PMID: 925486.
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    106. Keeley FW. The extraction and partial characterization of proteins released by decalcification from calcified human aortic plaques. Biochim Biophys Acta. 1977 Oct 26; 494(2):384-94. PMID: 410453.
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    107. Keeley FW. Detection and estimation of newly synthesized soluble elastin using a hydroxyproline label. Adv Exp Med Biol. 1977; 79:429-42. PMID: 868652.
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    108. Keeley FW. A convenient method for the identification and estimation of soluble elastin synthesis in vitro. Connect Tissue Res. 1976; 4(3):193-203. PMID: 134872.
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    109. Keeley FW, Partridge SM. Amino acid composition and calcification of human aortic elastin. Atherosclerosis. 1974 Mar-Apr; 19(2):287-96. PMID: 4591537.
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    110. Partridge SM, Keeley FW. Age related and atherosclerotic changes in aortic elastin. Adv Exp Med Biol. 1974; 43(0):173-91. PMID: 4599722.
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    111. Keeley FW, Labella FS. Isolation of dityrosine from an alkali-soluble connective tissue protein. Biochim Biophys Acta. 1972 Mar 15; 263(1):52-9. PMID: 5013290.
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    112. Keeley FW, LaBella F, Queen G. Dityrosine in a non-hydroxyproline, alkali-soluble protein isolated from chick aorta and bovine ligament. Biochem Biophys Res Commun. 1969 Jan 27; 34(2):156-61. PMID: 5796734.
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    113. LaBella F, Keeley F, Vivian S, Thornhill D. Evidence for dityrosine in elastin. Biochem Biophys Res Commun. 1967 Mar 21; 26(6):748-53. PMID: 6030988.
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    114. Gamborg OL, Keeley FW. Aromatic metabolism in plants. I. A study of the prephenate dehydrogenase from bean plants. Biochim Biophys Acta. 1966 Jan 25; 115(1):65-72. PMID: 4379953.
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