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Chaim Roifman

TitleStaff Physician
InstitutionThe Hospital for Sick Children
DepartmentImmunology & Allergy
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Suresh S, Dadi H, Reid B, Vong L, Bulman DE, Roifman CM. Time-dependent decline of T-cell receptor excision circle levels in ZAP-70 deficiency. J Allergy Clin Immunol Pract. 2019 Aug 23. PMID: 31449923.
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    2. Cologne A, Benoit-Pilven C, Besson A, Putoux A, Campan-Fournier A, Bober MB, De Die-Smulders CEM, Paulussen ADC, Pinson L, Toutain A, Roifman CM, Leutenegger AL, Mazoyer S, Edery P, Lacroix V. New insights into minor splicing-a transcriptomic analysis of cells derived from TALS patients. RNA. 2019 Sep; 25(9):1130-1149. PMID: 31175170.
      View in: PubMed
    3. Scott O, Roifman CM. NF-?B pathway and the Goldilocks principle: Lessons from human disorders of immunity and inflammation. J Allergy Clin Immunol. 2019 May; 143(5):1688-1701. PMID: 30940520.
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    4. Ovadia A, Sharfe N, Hawkins C, Laughlin S, Roifman CM. Two different STAT1 gain-of-function mutations lead to diverse IFN-?-mediated gene expression. NPJ Genom Med. 2018; 3:23. PMID: 30131873.
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    5. Biggs CM, Haddad E, Issekutz TB, Roifman CM, Turvey SE. Newborn screening for severe combined immunodeficiency: a primer for clinicians. CMAJ. 2017 12 18; 189(50):E1551-E1557. PMID: 29255099.
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    6. Sharfe N, Karanxha A, Dadi H, Merico D, Chitayat D, Herbrick JA, Freeman S, Grinstein S, Roifman CM. Dual loss of p110d PI3-kinase and SKAP (KNSTRN) expression leads to combined immunodeficiency and multisystem syndromic features. J Allergy Clin Immunol. 2018 08; 142(2):618-629. PMID: 29180244.
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    7. Kim VH, Reid B, Atkinson A, Upton J, Grunebaum E, Roifman CM. Long-term immune reconstitution after matched unrelated hematopoietic stem cell transplantation for immunodeficiency. J Allergy Clin Immunol. 2018 03; 141(3):1154-1157.e3. PMID: 29128672.
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    8. Dadi H, Jones TA, Merico D, Sharfe N, Ovadia A, Schejter Y, Reid B, Sun M, Vong L, Atkinson A, Lavi S, Pomerantz JL, Roifman CM. Combined immunodeficiency and atopy caused by a dominant negative mutation in caspase activation and recruitment domain family member 11 (CARD11). J Allergy Clin Immunol. 2018 05; 141(5):1818-1830.e2. PMID: 28826773.
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    9. Dinur Schejter Y, Ovadia A, Alexandrova R, Thiruvahindrapuram B, Pereira SL, Manson DE, Vincent A, Merico D, Roifman CM. A homozygous mutation in the stem II domain of RNU4ATAC causes typical Roifman syndrome. NPJ Genom Med. 2017; 2:23. PMID: 29263834.
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    10. Leiding JW, Okada S, Hagin D, Abinun M, Shcherbina A, Balashov DN, Kim VHD, Ovadia A, Guthery SL, Pulsipher M, Lilic D, Devlin LA, Christie S, Depner M, Fuchs S, van Royen-Kerkhof A, Lindemans C, Petrovic A, Sullivan KE, Bunin N, Kilic SS, Arpaci F, Calle-Martin O, Martinez-Martinez L, Aldave JC, Kobayashi M, Ohkawa T, Imai K, Iguchi A, Roifman CM, Gennery AR, Slatter M, Ochs HD, Morio T, Torgerson TR. Hematopoietic stem cell transplantation in patients with gain-of-function signal transducer and activator of transcription 1 mutations. J Allergy Clin Immunol. 2018 02; 141(2):704-717.e5. PMID: 28601685.
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    11. Chinn IK, Sanders RP, Stray-Pedersen A, Coban-Akdemir ZH, Kim VH, Dadi H, Roifman CM, Quigg T, Lupski JR, Orange JS, Hanson IC. Novel Combined Immune Deficiency and Radiation Sensitivity Blended Phenotype in an Adult with Biallelic Variations in ZAP70 and RNF168. Front Immunol. 2017; 8:576. PMID: 28603521.
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    12. Ovadia A, Dinur Schejter Y, Grunebaum E, Kim VH, Reid B, Schechter T, Pope E, Roifman CM. Hematopoietic stem cell transplantation for RelB deficiency. J Allergy Clin Immunol. 2017 10; 140(4):1199-1201.e3. PMID: 28552761.
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    13. Kahr WH, Pluthero FG, Elkadri A, Warner N, Drobac M, Chen CH, Lo RW, Li L, Li R, Li Q, Thoeni C, Pan J, Leung G, Lara-Corrales I, Murchie R, Cutz E, Laxer RM, Upton J, Roifman CM, Yeung RS, Brumell JH, Muise AM. Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease. Nat Commun. 2017 04 03; 8:14816. PMID: 28368018.
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    14. Walter JE, Rosen LB, Csomos K, Rosenberg JM, Mathew D, Keszei M, Ujhazi B, Chen K, Lee YN, Tirosh I, Dobbs K, Al-Herz W, Cowan MJ, Puck J, Bleesing JJ, Grimley MS, Malech H, De Ravin SS, Gennery AR, Abraham RS, Joshi AY, Boyce TG, Butte MJ, Nadeau KC, Balboni I, Sullivan KE, Akhter J, Adeli M, El-Feky RA, El-Ghoneimy DH, Dbaibo G, Wakim R, Azzari C, Palma P, Cancrini C, Capuder K, Condino-Neto A, Costa-Carvalho BT, Oliveira JB, Roifman C, Buchbinder D, Kumanovics A, Franco JL, Niehues T, Schuetz C, Kuijpers T, Yee C, Chou J, Masaad MJ, Geha R, Uzel G, Gelman R, Holland SM, Recher M, Utz PJ, Browne SK, Notarangelo LD. Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency. J Clin Invest. 2016 11 01; 126(11):4389. PMID: 27801680.
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    15. de la Morena MT, Leonard D, Torgerson TR, Cabral-Marques O, Slatter M, Aghamohammadi A, Chandra S, Murguia-Favela L, Bonilla FA, Kanariou M, Damrongwatanasuk R, Kuo CY, Dvorak CC, Meyts I, Chen K, Kobrynski L, Kapoor N, Richter D, DiGiovanni D, Dhalla F, Farmaki E, Speckmann C, Español T, Shcherbina A, Hanson IC, Litzman J, Routes JM, Wong M, Fuleihan R, Seneviratne SL, Small TN, Janda A, Bezrodnik L, Seger R, Raccio AG, Edgar JD, Chou J, Abbott JK, van Montfrans J, González-Granado LI, Bunin N, Kutukculer N, Gray P, Seminario G, Pasic S, Aquino V, Wysocki C, Abolhassani H, Dorsey M, Cunningham-Rundles C, Knutsen AP, Sleasman J, Costa Carvalho BT, Condino-Neto A, Grunebaum E, Chapel H, Ochs HD, Filipovich A, Cowan M, Gennery A, Cant A, Notarangelo LD, Roifman CM. Long-term outcomes of 176 patients with X-linked hyper-IgM syndrome treated with or without hematopoietic cell transplantation. J Allergy Clin Immunol. 2017 Apr; 139(4):1282-1292. PMID: 27697500.
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    16. Lam GK, Abdelhaleem M, Somers GR, Roifman C, Read S, Abla O. Primary Effusion Lymphoma (PEL)-Like Lymphoma in a Child With Congenital Immunodeficiency. Pediatr Blood Cancer. 2016 09; 63(9):1674-6. PMID: 27186682.
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    17. Grunebaum E, Kim VH, Somers GR, Shammas A, Roifman CM. Bone marrow transplantation for monoallelic signal transducer and activator of transcription 1 deficiency. J Allergy Clin Immunol. 2016 08; 138(2):612-615.e1. PMID: 27061251.
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    18. Li Q, Lee CH, Peters LA, Mastropaolo LA, Thoeni C, Elkadri A, Schwerd T, Zhu J, Zhang B, Zhao Y, Hao K, Dinarzo A, Hoffman G, Kidd BA, Murchie R, Al Adham Z, Guo C, Kotlarz D, Cutz E, Walters TD, Shouval DS, Curran M, Dobrin R, Brodmerkel C, Snapper SB, Klein C, Brumell JH, Hu M, Nanan R, Snanter-Nanan B, Wong M, Le Deist F, Haddad E, Roifman CM, Deslandres C, Griffiths AM, Gaskin KJ, Uhlig HH, Schadt EE, Muise AM. Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease. Gastroenterology. 2016 05; 150(5):1196-1207. PMID: 26836588.
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    19. Merico D, Roifman M, Braunschweig U, Yuen RK, Alexandrova R, Bates A, Reid B, Nalpathamkalam T, Wang Z, Thiruvahindrapuram B, Gray P, Kakakios A, Peake J, Hogarth S, Manson D, Buncic R, Pereira SL, Herbrick JA, Blencowe BJ, Roifman CM, Scherer SW. Compound heterozygous mutations in the noncoding RNU4ATAC cause Roifman Syndrome by disrupting minor intron splicing. Nat Commun. 2015 Nov 02; 6:8718. PMID: 26522830.
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    20. Walter JE, Rosen LB, Csomos K, Rosenberg JM, Mathew D, Keszei M, Ujhazi B, Chen K, Lee YN, Tirosh I, Dobbs K, Al-Herz W, Cowan MJ, Puck J, Bleesing JJ, Grimley MS, Malech H, De Ravin SS, Gennery AR, Abraham RS, Joshi AY, Boyce TG, Butte MJ, Nadeau KC, Balboni I, Sullivan KE, Akhter J, Adeli M, El-Feky RA, El-Ghoneimy DH, Dbaibo G, Wakim R, Azzari C, Palma P, Cancrini C, Capuder K, Condino-Neto A, Costa-Carvalho BT, Oliveira JB, Roifman C, Buchbinder D, Kumanovics A, Franco JL, Niehues T, Schuetz C, Kuijpers T, Yee C, Chou J, Masaad MJ, Geha R, Uzel G, Gelman R, Holland SM, Recher M, Utz PJ, Browne SK, Notarangelo LD. Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency. J Clin Invest. 2015 Nov 02; 125(11):4135-48. PMID: 26457731.
      View in: PubMed
    21. Sharfe N, Merico D, Karanxha A, Macdonald C, Dadi H, Ngan B, Herbrick JA, Roifman CM. The effects of RelB deficiency on lymphocyte development and function. J Autoimmun. 2015 Dec; 65:90-100. PMID: 26385063.
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    22. Elkadri A, Thoeni C, Deharvengt SJ, Murchie R, Guo C, Stavropoulos JD, Marshall CR, Wales P, Bandsma R, Cutz E, Roifman CM, Chitayat D, Avitzur Y, Stan RV, Muise AM. Mutations in Plasmalemma Vesicle Associated Protein Result in Sieving Protein-Losing Enteropathy Characterized by Hypoproteinemia, Hypoalbuminemia, and Hypertriglyceridemia. Cell Mol Gastroenterol Hepatol. 2015 Jul; 1(4):381-394.e7. PMID: 26207260.
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    23. Modell V, Knaus M, Modell F, Roifman C, Orange J, Notarangelo LD. Global overview of primary immunodeficiencies: a report from Jeffrey Modell Centers worldwide focused on diagnosis, treatment, and discovery. Immunol Res. 2014 Oct; 60(1):132-44. PMID: 24668296.
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    24. Fuchs S, Rensing-Ehl A, Erlacher M, Vraetz T, Hartjes L, Janda A, Rizzi M, Lorenz MR, Gilmour K, de Saint-Basile G, Roifman CM, Cheuk S, Gennery A, Thrasher AJ, Fuchs I, Schwarz K, Speckmann C, Ehl S. Patients with T?/low NK? IL-2 receptor ? chain deficiency have differentially-impaired cytokine signaling resulting in severe combined immunodeficiency. Eur J Immunol. 2014 Oct; 44(10):3129-40. PMID: 25042067.
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    25. Dhanju R, Min W, Ackerley C, Cimpean L, Palaniyar N, Roifman CM, Grunebaum E. Pulmonary alveolar proteinosis in adenosine deaminase-deficient mice. J Allergy Clin Immunol. 2014 May; 133(5):1467-71, 1471.e1-4. PMID: 24439080.
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    26. Grunebaum E, Cohen A, Roifman CM. Recent advances in understanding and managing adenosine deaminase and purine nucleoside phosphorylase deficiencies. Curr Opin Allergy Clin Immunol. 2013 Dec; 13(6):630-8. PMID: 24113229.
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    27. Sharfe N, Nahum A, Newell A, Dadi H, Ngan B, Pereira SL, Herbrick JA, Roifman CM. Fatal combined immunodeficiency associated with heterozygous mutation in STAT1. J Allergy Clin Immunol. 2014 Mar; 133(3):807-17. PMID: 24239102.
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    28. Berglund LJ, Avery DT, Ma CS, Moens L, Deenick EK, Bustamante J, Boisson-Dupuis S, Wong M, Adelstein S, Arkwright PD, Bacchetta R, Bezrodnik L, Dadi H, Roifman CM, Fulcher DA, Ziegler JB, Smart JM, Kobayashi M, Picard C, Durandy A, Cook MC, Casanova JL, Uzel G, Tangye SG. IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts. Blood. 2013 Dec 05; 122(24):3940-50. PMID: 24159173.
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    29. Boonyawat B, Dhanraj S, Al Abbas F, Zlateska B, Grunenbaum E, Roifman CM, Steele L, Meyn S, Blanchette V, Scherer SW, Swierczek S, Prchal J, Zhu Q, Torgerson TR, Ochs HD, Dror Y. Combined de-novo mutation and non-random X-chromosome inactivation causing Wiskott-Aldrich syndrome in a female with thrombocytopenia. J Clin Immunol. 2013 Oct; 33(7):1150-5. PMID: 23943155.
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    30. Al-Zahrani D, Al-Ghonaium A, Al-Mousa H, Al-Kassar A, Roifman CM. Skeletal abnormalities and successful hematopoietic stem cell transplantation in patients with reticular dysgenesis. J Allergy Clin Immunol. 2013 Oct; 132(4):993-6. PMID: 23763981.
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    31. Bousfiha AA, Jeddane L, Ailal F, Al Herz W, Conley ME, Cunningham-Rundles C, Etzioni A, Fischer A, Franco JL, Geha RS, Hammarström L, Nonoyama S, Ochs HD, Roifman CM, Seger R, Tang ML, Puck JM, Chapel H, Notarangelo LD, Casanova JL. A phenotypic approach for IUIS PID classification and diagnosis: guidelines for clinicians at the bedside. J Clin Immunol. 2013 Aug; 33(6):1078-87. PMID: 23657403.
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    32. Grunebaum E, Daneman A, Murguia-Favela L, Manson D, Kim VH, Roifman CM, Grunebaum M. Multiple osteochondromas following irradiation-containing conditioning in severe combined immunodeficiency. Br J Haematol. 2013 May; 161(3):446-8. PMID: 23384194.
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    33. Muñoz-Ruiz M, Pérez-Flores V, Garcillán B, Guardo AC, Mazariegos MS, Takada H, Allende LM, Kilic SS, Sanal O, Roifman CM, López-Granados E, Recio MJ, Martínez-Naves E, Fernández-Malavé E, Regueiro JR. Human CD3?, but not CD3d, haploinsufficiency differentially impairs ?d versus aß surface TCR expression. BMC Immunol. 2013 Jan 21; 14:3. PMID: 23336327.
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    34. Moran CJ, Walters TD, Guo CH, Kugathasan S, Klein C, Turner D, Wolters VM, Bandsma RH, Mouzaki M, Zachos M, Langer JC, Cutz E, Benseler SM, Roifman CM, Silverberg MS, Griffiths AM, Snapper SB, Muise AM. IL-10R polymorphisms are associated with very-early-onset ulcerative colitis. Inflamm Bowel Dis. 2013 Jan; 19(1):115-23. PMID: 22550014.
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    35. Poliani PL, Fontana E, Roifman CM, Notarangelo LD. ? Chain-associated protein of 70 kDa (ZAP70) deficiency in human subjects is associated with abnormalities of thymic stromal cells: Implications for T-cell tolerance. J Allergy Clin Immunol. 2013 Feb; 131(2):597-600.e1-2. PMID: 23245794.
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    36. Manson D, Diamond L, Oudjhane K, Hussain FB, Roifman C, Grunebaum E. Characteristic scapular and rib changes on chest radiographs of children with ADA-deficiency SCIDS in the first year of life. Pediatr Radiol. 2013 Mar; 43(5):589-92. PMID: 23179487.
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    37. Kim VH, Murguia L, Schechter T, Grunebaum E, Roifman CM. Emergency treatment for ? chain-associated protein of 70 kDa (ZAP70) deficiency. J Allergy Clin Immunol. 2013 Apr; 131(4):1233-5. PMID: 23141738.
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    38. Naithani R, Ngan BY, Roifman C, Crump M, Baruchel S, Abla O. Thymic mucosa-associated lymphoid tissue lymphoma in an adolescent girl. J Pediatr Hematol Oncol. 2012 Oct; 34(7):552-5. PMID: 22469942.
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    39. Weller S, Bonnet M, Delagreverie H, Israel L, Chrabieh M, Maródi L, Rodriguez-Gallego C, Garty BZ, Roifman C, Issekutz AC, Zitnik SE, Hoarau C, Camcioglu Y, Vasconcelos J, Rodrigo C, Arkwright PD, Cerutti A, Meffre E, Zhang SY, Alcais A, Puel A, Casanova JL, Picard C, Weill JC, Reynaud CA. IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4-, MyD88-, and TIRAP- but not UNC-93B-deficient patients. Blood. 2012 Dec 13; 120(25):4992-5001. PMID: 23002119.
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    40. Schechter T, Avila L, Frangoul H, Domm J, Dupuis LL, Naithani R, Zhao X, Pollock-Barziv S, Roifman C, Gassas A, Doyle J. Effect of acute graft-versus-host disease on the outcome of second allogeneic hematopoietic stem cell transplant in children. Leuk Lymphoma. 2013 Jan; 54(1):105-9. PMID: 22721498.
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    41. Hassan A, Booth C, Brightwell A, Allwood Z, Veys P, Rao K, Hönig M, Friedrich W, Gennery A, Slatter M, Bredius R, Finocchi A, Cancrini C, Aiuti A, Porta F, Lanfranchi A, Ridella M, Steward C, Filipovich A, Marsh R, Bordon V, Al-Muhsen S, Al-Mousa H, Alsum Z, Al-Dhekri H, Al Ghonaium A, Speckmann C, Fischer A, Mahlaoui N, Nichols KE, Grunebaum E, Al Zahrani D, Roifman CM, Boelens J, Davies EG, Cavazzana-Calvo M, Notarangelo L, Gaspar HB. Outcome of hematopoietic stem cell transplantation for adenosine deaminase-deficient severe combined immunodeficiency. Blood. 2012 Oct 25; 120(17):3615-24; quiz 3626. PMID: 22791287.
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    42. Roifman CM, Somech R, Kavadas F, Pires L, Nahum A, Dalal I, Grunebaum E. Defining combined immunodeficiency. J Allergy Clin Immunol. 2012 Jul; 130(1):177-83. PMID: 22664165.
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    43. Mansouri A, Min W, Cole CJ, Josselyn SA, Henderson JT, van Eede M, Henkelman RM, Ackerley C, Grunebaum E, Roifman CM. Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice. Neurobiol Dis. 2012 Aug; 47(2):201-9. PMID: 22521465.
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    44. Grunebaum E, Cutz E, Roifman CM. Pulmonary alveolar proteinosis in patients with adenosine deaminase deficiency. J Allergy Clin Immunol. 2012 Jun; 129(6):1588-93. PMID: 22409989.
      View in: PubMed
    45. Al-Herz W, Bousfiha A, Casanova JL, Chapel H, Conley ME, Cunningham-Rundles C, Etzioni A, Fischer A, Franco JL, Geha RS, Hammarström L, Nonoyama S, Notarangelo LD, Ochs HD, Puck JM, Roifman CM, Seger R, Tang ML. Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency. Front Immunol. 2011; 2:54. PMID: 22566844.
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    46. Nahum A, Dadi H, Bates A, Roifman CM. The biological significance of TLR3 variant, L412F, in conferring susceptibility to cutaneous candidiasis, CMV and autoimmunity. Autoimmun Rev. 2012 Mar; 11(5):341-7. PMID: 22024499.
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    47. Modell V, Gee B, Lewis DB, Orange JS, Roifman CM, Routes JM, Sorensen RU, Notarangelo LD, Modell F. Global study of primary immunodeficiency diseases (PI)--diagnosis, treatment, and economic impact: an updated report from the Jeffrey Modell Foundation. Immunol Res. 2011 Oct; 51(1):61-70. PMID: 21935653.
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    48. Papinazath T, Min W, Sujiththa S, Cohen A, Ackerley C, Roifman CM, Grunebaum E. Effects of purine nucleoside phosphorylase deficiency on thymocyte development. J Allergy Clin Immunol. 2011 Oct; 128(4):854-863.e1. PMID: 21868080.
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    49. Marcus N, Takada H, Law J, Cowan MJ, Gil J, Regueiro JR, Plaza Lopez de Sabando D, Lopez-Granados E, Dalal J, Friedrich W, Manfred H, Hanson IC, Grunebaum E, Shearer WT, Roifman CM. Hematopoietic stem cell transplantation for CD3d deficiency. J Allergy Clin Immunol. 2011 Nov; 128(5):1050-7. PMID: 21757226.
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    50. Tsangaris E, Klaassen R, Fernandez CV, Yanofsky R, Shereck E, Champagne J, Silva M, Lipton JH, Brossard J, Michon B, Abish S, Steele M, Ali K, Dower N, Athale U, Jardine L, Hand JP, Odame I, Canning P, Allen C, Carcao M, Beyene J, Roifman CM, Dror Y. Genetic analysis of inherited bone marrow failure syndromes from one prospective, comprehensive and population-based cohort and identification of novel mutations. J Med Genet. 2011 Sep; 48(9):618-28. PMID: 21659346.
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    51. Barron MA, Makhija M, Hagen LE, Pencharz P, Grunebaum E, Roifman CM. Increased resting energy expenditure is associated with failure to thrive in infants with severe combined immunodeficiency. J Pediatr. 2011 Oct; 159(4):628-32.e1. PMID: 21592502.
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    52. Grunebaum E, Chung CT, Dadi H, Kim P, Brigida I, Ferrua F, Cicalese MP, Aiuti A, Roifman CM. Purine metabolism, immune reconstitution, and abdominal adipose tumor after gene therapy for adenosine deaminase deficiency. J Allergy Clin Immunol. 2011 Jun; 127(6):1417-9.e3. PMID: 21531016.
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    53. Nicholas S, Krance RA, Hanson IC, Chinen J, Mamlok RJ, Roifman CM, Shearer WT. Early versus delayed diagnosis of SCID: triumph versus tragedy. Clin Immunol. 2011 Jun; 139(3):360-2. PMID: 21497138.
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    54. Borte M, Bernatowska E, Ochs HD, Roifman CM. Efficacy and safety of home-based subcutaneous immunoglobulin replacement therapy in paediatric patients with primary immunodeficiencies. Clin Exp Immunol. 2011 Jun; 164(3):357-64. PMID: 21413943.
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    55. Grunebaum E, Roifman CM. Bone marrow transplantation using HLA-matched unrelated donors for patients suffering from severe combined immunodeficiency. Hematol Oncol Clin North Am. 2011 Feb; 25(1):63-73. PMID: 21236390.
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    56. Briggs TA, Rice GI, Daly S, Urquhart J, Gornall H, Bader-Meunier B, Baskar K, Baskar S, Baudouin V, Beresford MW, Black GC, Dearman RJ, de Zegher F, Foster ES, Francès C, Hayman AR, Hilton E, Job-Deslandre C, Kulkarni ML, Le Merrer M, Linglart A, Lovell SC, Maurer K, Musset L, Navarro V, Picard C, Puel A, Rieux-Laucat F, Roifman CM, Scholl-Bürgi S, Smith N, Szynkiewicz M, Wiedeman A, Wouters C, Zeef LA, Casanova JL, Elkon KB, Janckila A, Lebon P, Crow YJ. Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature. Nat Genet. 2011 Feb; 43(2):127-31. PMID: 21217755.
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    57. Roifman CM, Dadi H, Somech R, Nahum A, Sharfe N. Characterization of ?-associated protein, 70 kd (ZAP70)-deficient human lymphocytes. J Allergy Clin Immunol. 2010 Dec; 126(6):1226-33.e1. PMID: 20864151.
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    58. Newell A, Dadi H, Goldberg R, Ngan BY, Grunebaum E, Roifman CM. Diffuse large B-cell lymphoma as presenting feature of Zap-70 deficiency. J Allergy Clin Immunol. 2011 Feb; 127(2):517-20. PMID: 21094993.
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    59. Nahum A, Dadi H, Bates A, Roifman CM. The L412F variant of Toll-like receptor 3 (TLR3) is associated with cutaneous candidiasis, increased susceptibility to cytomegalovirus, and autoimmunity. J Allergy Clin Immunol. 2011 Feb; 127(2):528-31. PMID: 21093032.
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    60. Picard C, von Bernuth H, Ghandil P, Chrabieh M, Levy O, Arkwright PD, McDonald D, Geha RS, Takada H, Krause JC, Creech CB, Ku CL, Ehl S, Maródi L, Al-Muhsen S, Al-Hajjar S, Al-Ghonaium A, Day-Good NK, Holland SM, Gallin JI, Chapel H, Speert DP, Rodriguez-Gallego C, Colino E, Garty BZ, Roifman C, Hara T, Yoshikawa H, Nonoyama S, Domachowske J, Issekutz AC, Tang M, Smart J, Zitnik SE, Hoarau C, Kumararatne DS, Thrasher AJ, Davies EG, Bethune C, Sirvent N, de Ricaud D, Camcioglu Y, Vasconcelos J, Guedes M, Vitor AB, Rodrigo C, Almazán F, Méndez M, Aróstegui JI, Alsina L, Fortuny C, Reichenbach J, Verbsky JW, Bossuyt X, Doffinger R, Abel L, Puel A, Casanova JL. Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. Medicine (Baltimore). 2010 Nov; 89(6):403-25. PMID: 21057262.
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    61. Al-Sukaiti N, Reid B, Lavi S, Al-Zaharani D, Atkinson A, Roifman CM, Grunebaum E. Safety and efficacy of measles, mumps, and rubella vaccine in patients with DiGeorge syndrome. J Allergy Clin Immunol. 2010 Oct; 126(4):868-9. PMID: 20810153.
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    62. Roifman CM. Each condition should be carefully studied, ideally with homogenous patient groups. Preface. Immunol Allergy Clin North Am. 2010 May; 30(2):xi. PMID: 20493392.
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    63. Roifman CM. Hematopoietic stem cell transplantation for profound T-cell deficiency (combined immunodeficiency). Immunol Allergy Clin North Am. 2010 May; 30(2):209-19. PMID: 20493397.
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    64. Roifman CM, Fischer A, Notarangelo LD, de la Morena MT, Seger RA. Indications for hemopoietic stem cell transplantation. Immunol Allergy Clin North Am. 2010 May; 30(2):261-2. PMID: 20493401.
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    65. Roifman CM. Preface. Immunol Allergy Clin North Am. 2010 Feb; 30(1):xiii-xiv. PMID: 20113882.
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    66. Grunebaum E, Roifman CM. Bone marrow transplantation using HLA-matched unrelated donors for patients suffering from severe combined immunodeficiency. Immunol Allergy Clin North Am. 2010 Feb; 30(1):63-73. PMID: 20113887.
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    67. Puel A, Döffinger R, Natividad A, Chrabieh M, Barcenas-Morales G, Picard C, Cobat A, Ouachée-Chardin M, Toulon A, Bustamante J, Al-Muhsen S, Al-Owain M, Arkwright PD, Costigan C, McConnell V, Cant AJ, Abinun M, Polak M, Bougnères PF, Kumararatne D, Marodi L, Nahum A, Roifman C, Blanche S, Fischer A, Bodemer C, Abel L, Lilic D, Casanova JL. Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. J Exp Med. 2010 Feb 15; 207(2):291-7. PMID: 20123958.
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    68. Griffith LM, Cowan MJ, Notarangelo LD, Puck JM, Buckley RH, Candotti F, Conley ME, Fleisher TA, Gaspar HB, Kohn DB, Ochs HD, O'Reilly RJ, Rizzo JD, Roifman CM, Small TN, Shearer WT. Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management. J Allergy Clin Immunol. 2009 Dec; 124(6):1152-60.e12. PMID: 20004776.
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    69. Notarangelo LD, Fischer A, Geha RS, Casanova JL, Chapel H, Conley ME, Cunningham-Rundles C, Etzioni A, Hammartröm L, Nonoyama S, Ochs HD, Puck J, Roifman C, Seger R, Wedgwood J. Primary immunodeficiencies: 2009 update. J Allergy Clin Immunol. 2009 Dec; 124(6):1161-78. PMID: 20004777.
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    70. Roifman CM, Chitayat D. Combined immunodeficiency, facial dysmorphism, optic nerve atrophy, skeletal anomalies and developmental delay: a new syndrome. Clin Genet. 2009 Nov; 76(5):449-57. PMID: 19863561.
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    71. Somech R, Simon AJ, Lev A, Dalal I, Spirer Z, Goldstein I, Nagar M, Amariglio N, Rechavi G, Roifman CM. Reduced central tolerance in Omenn syndrome leads to immature self-reactive oligoclonal T cells. J Allergy Clin Immunol. 2009 Oct; 124(4):793-800. PMID: 19767069.
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    72. Somech R, Lai YH, Grunebaum E, Le Saux N, Cutz E, Roifman CM. Polyethylene glycol-modified adenosine deaminase improved lung disease but not liver disease in partial adenosine deaminase deficiency. J Allergy Clin Immunol. 2009 Oct; 124(4):848-50. PMID: 19665771.
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    73. Angelini P, Kavadas F, Sharma N, Richardson SE, Tipples G, Roifman C, Dror Y, Nofech-Mozes Y. Aplastic anemia following varicella vaccine. Pediatr Infect Dis J. 2009 Aug; 28(8):746-8. PMID: 19633522.
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    74. Yu Y, Arora A, Min W, Roifman CM, Grunebaum E. EdU incorporation is an alternative non-radioactive assay to [(3)H]thymidine uptake for in vitro measurement of mice T-cell proliferations. J Immunol Methods. 2009 Oct 31; 350(1-2):29-35. PMID: 19647746.
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    75. Sauer AV, Mrak E, Hernandez RJ, Zacchi E, Cavani F, Casiraghi M, Grunebaum E, Roifman CM, Cervi MC, Ambrosi A, Carlucci F, Roncarolo MG, Villa A, Rubinacci A, Aiuti A. ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency. Blood. 2009 Oct 08; 114(15):3216-26. PMID: 19633200.
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    76. Poliani PL, Facchetti F, Ravanini M, Gennery AR, Villa A, Roifman CM, Notarangelo LD. Early defects in human T-cell development severely affect distribution and maturation of thymic stromal cells: possible implications for the pathophysiology of Omenn syndrome. Blood. 2009 Jul 02; 114(1):105-8. PMID: 19414857.
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    77. Nahum A, Reid B, Grunebaum E, Roifman CM. Matched unrelated bone marrow transplant for Omenn syndrome. Immunol Res. 2009; 44(1-3):25-34. PMID: 18854956.
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    78. Liao P, Toro A, Min W, Lee S, Roifman CM, Grunebaum E. Lentivirus gene therapy for purine nucleoside phosphorylase deficiency. J Gene Med. 2008 Dec; 10(12):1282-93. PMID: 18924118.
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    79. Notarangelo LD, Roifman CM, Giliani S. Cartilage-hair hypoplasia: molecular basis and heterogeneity of the immunological phenotype. Curr Opin Allergy Clin Immunol. 2008 Dec; 8(6):534-9. PMID: 18978468.
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    80. Nahum A, Bates A, Sharfe N, Roifman CM. Association of the lymphoid protein tyrosine phosphatase, R620W variant, with chronic mucocutaneous candidiasis. J Allergy Clin Immunol. 2008 Dec; 122(6):1220-2. PMID: 19084113.
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    81. Griffith LM, Cowan MJ, Kohn DB, Notarangelo LD, Puck JM, Schultz KR, Buckley RH, Eapen M, Kamani NR, O'Reilly RJ, Parkman R, Roifman CM, Sullivan KE, Filipovich AH, Fleisher TA, Shearer WT. Allogeneic hematopoietic cell transplantation for primary immune deficiency diseases: current status and critical needs. J Allergy Clin Immunol. 2008 Dec; 122(6):1087-96. PMID: 18992926.
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    82. Villa A, Notarangelo LD, Roifman CM. Omenn syndrome: inflammation in leaky severe combined immunodeficiency. J Allergy Clin Immunol. 2008 Dec; 122(6):1082-6. PMID: 18992930.
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    83. Roifman CM. Intravenous immunoglobulin treatment of immunodeficiency. Preface. Immunol Allergy Clin North Am. 2008 Nov; 28(4):xv-xvi. PMID: 18940569.
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    84. Membe SK, Ho C, Cimon K, Morrison A, Kanani A, Roifman CM. Economic assessment of different modalities of immunoglobulin replacement therapy. Immunol Allergy Clin North Am. 2008 Nov; 28(4):861-74, x. PMID: 18940579.
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    85. Roifman CM, Berger M, Notarangelo LD. Management of primary antibody deficiency with replacement therapy: summary of guidelines. Immunol Allergy Clin North Am. 2008 Nov; 28(4):875-6, x. PMID: 18940580.
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    86. Grunebaum E, Bates A, Roifman CM. Omenn syndrome is associated with mutations in DNA ligase IV. J Allergy Clin Immunol. 2008 Dec; 122(6):1219-20. PMID: 18845326.
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    87. Kavadas FD, Giliani S, Gu Y, Mazzolari E, Bates A, Pegoiani E, Roifman CM, Notarangelo LD. Variability of clinical and laboratory features among patients with ribonuclease mitochondrial RNA processing endoribonuclease gene mutations. J Allergy Clin Immunol. 2008 Dec; 122(6):1178-84. PMID: 18804272.
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    88. Somech R, Kavadas FD, Atkinson A, Grunebaum E, Roifman CM. High-dose methylprednisolone is effective in the management of acute graft-versus-host disease in severe combined immune deficiency. J Allergy Clin Immunol. 2008 Dec; 122(6):1215-6. PMID: 18672279.
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    89. de Beaucoudrey L, Puel A, Filipe-Santos O, Cobat A, Ghandil P, Chrabieh M, Feinberg J, von Bernuth H, Samarina A, Jannière L, Fieschi C, Stéphan JL, Boileau C, Lyonnet S, Jondeau G, Cormier-Daire V, Le Merrer M, Hoarau C, Lebranchu Y, Lortholary O, Chandesris MO, Tron F, Gambineri E, Bianchi L, Rodriguez-Gallego C, Zitnik SE, Vasconcelos J, Guedes M, Vitor AB, Marodi L, Chapel H, Reid B, Roifman C, Nadal D, Reichenbach J, Caragol I, Garty BZ, Dogu F, Camcioglu Y, Gülle S, Sanal O, Fischer A, Abel L, Stockinger B, Picard C, Casanova JL. Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells. J Exp Med. 2008 Jul 07; 205(7):1543-50. PMID: 18591412.
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    90. Roifman CM, Zhang J, Atkinson A, Grunebaum E, Mandel K. Adenosine deaminase deficiency can present with features of Omenn syndrome. J Allergy Clin Immunol. 2008 Apr; 121(4):1056-8. PMID: 18243287.
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    91. Roifman CM, Somech R, Grunebaum E. Matched unrelated bone marrow transplant for T+ combined immunodeficiency. Bone Marrow Transplant. 2008 Jun; 41(11):947-52. PMID: 18264145.
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    92. Bulley SR, Benson L, Grunebaum E, Roifman CM. Cardiac chamber hypertrophy following hematopoietic stem cell transplantation for primary immunodeficiency. Biol Blood Marrow Transplant. 2008 Feb; 14(2):229-35. PMID: 18215783.
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    93. Somech R, Somers GR, Chitayat D, Grunebaum E, Atkinson A, Kolomietz E, Roifman CM. Fatal lung fibrosis associated with immunodeficiency and gonadal dysgenesis in 46XX sisters--a new syndrome. Am J Med Genet A. 2008 Jan 01; 146A(1):8-14. PMID: 17937424.
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    94. Sharfe N, Nikolic M, Cimpeon L, Van De Kratts A, Freywald A, Roifman CM. EphA and ephrin-A proteins regulate integrin-mediated T lymphocyte interactions. Mol Immunol. 2008 Mar; 45(5):1208-20. PMID: 17980912.
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    95. Geha RS, Notarangelo LD, Casanova JL, Chapel H, Conley ME, Fischer A, Hammarström L, Nonoyama S, Ochs HD, Puck JM, Roifman C, Seger R, Wedgwood J. Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee. J Allergy Clin Immunol. 2007 Oct; 120(4):776-94. PMID: 17952897.
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    96. Ku CL, von Bernuth H, Picard C, Zhang SY, Chang HH, Yang K, Chrabieh M, Issekutz AC, Cunningham CK, Gallin J, Holland SM, Roifman C, Ehl S, Smart J, Tang M, Barrat FJ, Levy O, McDonald D, Day-Good NK, Miller R, Takada H, Hara T, Al-Hajjar S, Al-Ghonaium A, Speert D, Sanlaville D, Li X, Geissmann F, Vivier E, Maródi L, Garty BZ, Chapel H, Rodriguez-Gallego C, Bossuyt X, Abel L, Puel A, Casanova JL. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med. 2007 Oct 01; 204(10):2407-22. PMID: 17893200.
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    97. Nofech-Mozes Y, Blaser SI, Kobayashi J, Grunebaum E, Roifman CM. Neurologic abnormalities in patients with adenosine deaminase deficiency. Pediatr Neurol. 2007 Sep; 37(3):218-21. PMID: 17765813.
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    98. Atkinson AR, Roifman CM. Low serum immunoglobulin G2 levels in infancy can be transient. Pediatrics. 2007 Sep; 120(3):e543-7. PMID: 17682036.
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    99. Husain M, Grunebaum E, Naqvi A, Atkinson A, Ngan BY, Aiuti A, Roifman CM. Burkitt's lymphoma in a patient with adenosine deaminase deficiency-severe combined immunodeficiency treated with polyethylene glycol-adenosine deaminase. J Pediatr. 2007 Jul; 151(1):93-5. PMID: 17586199.
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    100. Lavine E, Somech R, Zhang JY, Puel A, Bossuyt X, Picard C, Casanova JL, Roifman CM. Cellular and humoral aberrations in a kindred with IL-1 receptor-associated kinase 4 deficiency. J Allergy Clin Immunol. 2007 Oct; 120(4):948-50. PMID: 17544092.
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    101. Roifman CM, Grunebaum E, Dalal I, Notarangelo L. Matched unrelated bone marrow transplant for severe combined immunodeficiency. Immunol Res. 2007; 38(1-3):191-200. PMID: 17917025.
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    102. Guggenheim R, Somech R, Grunebaum E, Atkinson A, Roifman CM. Bone marrow transplantation for cartilage-hair-hypoplasia. Bone Marrow Transplant. 2006 Dec; 38(11):751-6. PMID: 17041608.
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    103. Aoki CA, Roifman CM, Lian ZX, Bowlus CL, Norman GL, Shoenfeld Y, Mackay IR, Gershwin ME. IL-2 receptor alpha deficiency and features of primary biliary cirrhosis. J Autoimmun. 2006 Aug; 27(1):50-3. PMID: 16904870.
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    104. Candotti F, Roifman C, Puck JM. Immunodeficiencies: injecting some safety into SCID gene therapy? Gene Ther. 2006 May; 13(9):741-3. PMID: 18360945.
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    105. Freywald A, Sharfe N, Miller CD, Rashotte C, Roifman CM. EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes. J Immunol. 2006 Apr 01; 176(7):4066-74. PMID: 16547242.
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    106. Roifman CM, Gu Y, Cohen A. Mutations in the RNA component of RNase mitochondrial RNA processing might cause Omenn syndrome. J Allergy Clin Immunol. 2006 Apr; 117(4):897-903. PMID: 16630949.
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    107. Notarangelo L, Casanova JL, Conley ME, Chapel H, Fischer A, Puck J, Roifman C, Seger R, Geha RS. Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee Meeting in Budapest, 2005. J Allergy Clin Immunol. 2006 Apr; 117(4):883-96. PMID: 16680902.
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    108. Grunebaum E, Mazzolari E, Porta F, Dallera D, Atkinson A, Reid B, Notarangelo LD, Roifman CM. Bone marrow transplantation for severe combined immune deficiency. JAMA. 2006 Feb 01; 295(5):508-18. PMID: 16449616.
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    109. Nicolay U, Kiessling P, Berger M, Gupta S, Yel L, Roifman CM, Gardulf A, Eichmann F, Haag S, Massion C, Ochs HD. Health-related quality of life and treatment satisfaction in North American patients with primary immunedeficiency diseases receiving subcutaneous IgG self-infusions at home. J Clin Immunol. 2006 Jan; 26(1):65-72. PMID: 16418804.
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    110. Grunebaum E, Sharfe N, Roifman CM. Human T cell immunodeficiency: when signal transduction goes wrong. Immunol Res. 2006; 35(1-2):117-26. PMID: 17003514.
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    111. Yang K, Puel A, Zhang S, Eidenschenk C, Ku CL, Casrouge A, Picard C, von Bernuth H, Senechal B, Plancoulaine S, Al-Hajjar S, Al-Ghonaium A, Maródi L, Davidson D, Speert D, Roifman C, Garty BZ, Ozinsky A, Barrat FJ, Coffman RL, Miller RL, Li X, Lebon P, Rodriguez-Gallego C, Chapel H, Geissmann F, Jouanguy E, Casanova JL. Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses. Immunity. 2005 Nov; 23(5):465-78. PMID: 16286015.
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    112. Somech R, Roifman CM. Mutation analysis should be performed to rule out gammac deficiency in children with functional severe combined immune deficiency despite apparently normal immunologic tests. J Pediatr. 2005 Oct; 147(4):555-7. PMID: 16227049.
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    113. Zhang J, Quintal L, Atkinson A, Williams B, Grunebaum E, Roifman CM. Novel RAG1 mutation in a case of severe combined immunodeficiency. Pediatrics. 2005 Sep; 116(3):e445-9. PMID: 16061569.
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    114. Takada H, Nomura A, Roifman CM, Hara T. Severe combined immunodeficiency caused by a splicing abnormality of the CD3delta gene. Eur J Pediatr. 2005 May; 164(5):311-4. PMID: 15729559.
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    115. Roifman CM. Studies of patients' thymi aid in the discovery and characterization of immunodeficiency in humans. Immunol Rev. 2005 Feb; 203:143-55. PMID: 15661027.
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    116. Roifman CM. CD3 delta immunodeficiency. Curr Opin Allergy Clin Immunol. 2004 Dec; 4(6):479-84. PMID: 15640687.
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    117. Roifman CM. Signals find their target: drug design and diagnosis based on intracellular signalling. Clin Invest Med. 2004 Oct; 27(5):282-4. PMID: 15559865.
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    118. Grunebaum E, Zhang J, Roifman CM. Novel mutations and hot-spots in patients with purine nucleoside phosphorylase deficiency. Nucleosides Nucleotides Nucleic Acids. 2004 Oct; 23(8-9):1411-5. PMID: 15571269.
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    119. Demin P, Rounova O, Grunberger T, Cimpean L, Sharfe N, Roifman CM. Tyrenes: synthesis of new antiproliferative compounds with an extended conjugation. Bioorg Med Chem. 2004 Jun 01; 12(11):3019-26. PMID: 15142560.
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    120. Dror Y, Grunebaum E, Hitzler J, Narendran A, Ye C, Tellier R, Edwards V, Freedman MH, Roifman CM. Purine nucleoside phosphorylase deficiency associated with a dysplastic marrow morphology. Pediatr Res. 2004 Mar; 55(3):472-7. PMID: 14711904.
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    121. Dadi HK, Simon AJ, Roifman CM. Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency. N Engl J Med. 2003 Nov 06; 349(19):1821-8. PMID: 14602880.
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    122. Roifman CM, Schroeder H, Berger M, Sorensen R, Ballow M, Buckley RH, Gewurz A, Korenblat P, Sussman G, Lemm G. Comparison of the efficacy of IGIV-C, 10% (caprylate/chromatography) and IGIV-SD, 10% as replacement therapy in primary immune deficiency. A randomized double-blind trial. Int Immunopharmacol. 2003 Sep; 3(9):1325-33. PMID: 12890430.
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    123. Grunberger T, Demin P, Rounova O, Sharfe N, Cimpean L, Dadi H, Freywald A, Estrov Z, Roifman CM. Inhibition of acute lymphoblastic and myeloid leukemias by a novel kinase inhibitor. Blood. 2003 Dec 01; 102(12):4153-8. PMID: 12881315.
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    124. Sharfe N, Freywald A, Toro A, Roifman CM. Ephrin-A1 induces c-Cbl phosphorylation and EphA receptor down-regulation in T cells. J Immunol. 2003 Jun 15; 170(12):6024-32. PMID: 12794130.
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    125. Roifman CM, Melamed I. A novel syndrome of combined immunodeficiency, autoimmunity and spondylometaphyseal dysplasia. Clin Genet. 2003 Jun; 63(6):522-9. PMID: 12786759.
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    126. Chien W, Tidow N, Williamson EA, Shih LY, Krug U, Kettenbach A, Fermin AC, Roifman CM, Koeffler HP. Characterization of a myeloid tyrosine phosphatase, Lyp, and its role in the Bcr-Abl signal transduction pathway. J Biol Chem. 2003 Jul 25; 278(30):27413-20. PMID: 12764153.
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    127. Gu Y, Wang C, Roifman CM, Cohen A. Role of MHC class I in immune surveillance of mitochondrial DNA integrity. J Immunol. 2003 Apr 01; 170(7):3603-7. PMID: 12646623.
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    128. Freywald A, Sharfe N, Rashotte C, Grunberger T, Roifman CM. The EphB6 receptor inhibits JNK activation in T lymphocytes and modulates T cell receptor-mediated responses. J Biol Chem. 2003 Mar 21; 278(12):10150-6. PMID: 12517763.
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    129. Sharfe N, Freywald A, Toro A, Dadi H, Roifman C. Ephrin stimulation modulates T cell chemotaxis. Eur J Immunol. 2002 Dec; 32(12):3745-55. PMID: 12516569.
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    130. Grunebaum E, Roifman CM. Gene abnormalities in patients with hemophagocytic lymphohistiocytosis. Isr Med Assoc J. 2002 May; 4(5):366-9. PMID: 12040827.
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    131. Freywald A, Sharfe N, Roifman CM. The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1. J Biol Chem. 2002 Feb 08; 277(6):3823-8. PMID: 11713248.
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    132. Dror Y, Ginzberg H, Dalal I, Cherepanov V, Downey G, Durie P, Roifman CM, Freedman MH. Immune function in patients with Shwachman-Diamond syndrome. Br J Haematol. 2001 Sep; 114(3):712-7. PMID: 11553003.
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    133. Grunebaum E, Arpaia E, MacKenzie JJ, Fitzpatrick J, Ray PN, Roifman CM. A missense mutation in the SEDL gene results in delayed onset of X linked spondyloepiphyseal dysplasia in a large pedigree. J Med Genet. 2001 Jun; 38(6):409-11. PMID: 11424925.
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    134. Dalal I, Grunebaum E, Cohen A, Roifman CM. Two novel mutations in a purine nucleoside phosphorylase (PNP)-deficient patient. Clin Genet. 2001 Jun; 59(6):430-7. PMID: 11453975.
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    135. Grunebaum E, Roifman CM. Signal-transduction defects in T cells. Clin Rev Allergy Immunol. 2001 Feb; 20(1):27-42. PMID: 11269226.
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    136. Roifman CM, Zhang J, Chitayat D, Sharfe N. A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency. Blood. 2000 Oct 15; 96(8):2803-7. PMID: 11023514.
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    137. Manson DE, Sikka S, Reid B, Roifman C. Primary immunodeficiencies: a pictorial immunology primer for radiologists. Pediatr Radiol. 2000 Aug; 30(8):501-10. PMID: 10993534.
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    138. Roifman CM. Human IL-2 receptor alpha chain deficiency. Pediatr Res. 2000 Jul; 48(1):6-11. PMID: 10879793.
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    139. Arpaia E, Benveniste P, Di Cristofano A, Gu Y, Dalal I, Kelly S, Hershfield M, Pandolfi PP, Roifman CM, Cohen A. Mitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient mice. J Exp Med. 2000 Jun 19; 191(12):2197-208. PMID: 10859343.
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    140. Diav-Citrin O, Ratnapalan S, Grouhi M, Roifman C, Koren G. Medication errors in paediatrics: a case report and systematic review of risk factors. Paediatr Drugs. 2000 May-Jun; 2(3):239-42. PMID: 10937473.
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    141. Dalal I, Reid B, Doyle J, Freedman M, Calderwood S, Saunders F, Roifman CM. Matched unrelated bone marrow transplantation for combined immunodeficiency. Bone Marrow Transplant. 2000 Mar; 25(6):613-21. PMID: 10734295.
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    142. Grunebaum E, Zhang J, Dadi H, Roifman CM. Haemophagocytic lymphohistiocytosis in X-linked severe combined immunodeficiency. Br J Haematol. 2000 Mar; 108(4):834-7. PMID: 10792291.
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    143. Arpaia E, Gu Y, Dalal I, Kelly S, Hershfield M, Roifman CM, Cohen A. Biochemical and immunological abnormalities in purine nucleoside phosphorylase deficient mice. Adv Exp Med Biol. 2000; 486:41-5. PMID: 11783524.
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    144. Grouhi M, Alshehri M, Hummel D, Roifman CM. Anaphylaxis and epinephrine auto-injector training: who will teach the teachers? J Allergy Clin Immunol. 1999 Jul; 104(1):190-3. PMID: 10400860.
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    145. Grouhi M, Hummel D, Roifman CM. Anaphylactic reaction to oral cefaclor in a child. Pediatrics. 1999 Apr; 103(4):e50. PMID: 10103342.
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    146. Cohen S, Dadi H, Shaoul E, Sharfe N, Roifman CM. Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp. Blood. 1999 Mar 15; 93(6):2013-24. PMID: 10068674.
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    147. Roifman CM. Antibody deficiency, growth retardation, spondyloepiphyseal dysplasia and retinal dystrophy: a novel syndrome. Clin Genet. 1999 Feb; 55(2):103-9. PMID: 10189087.
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    148. Hebert D, Roifman C, Sherman PM. The future of pediatric transplantation. J Pediatr Gastroenterol Nutr. 1999 Feb; 28(2):122. PMID: 9932838.
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    149. Grouhi M, Wang E, Reid B, Roifman CM. Long-term remission for disseminated Mycobacterium avium-intracellulare complex associated with antibody deficiency. Pediatrics. 1999 Jan; 103(1):E13. PMID: 9917493.
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    150. Grouhi M, Dalal I, Nisbet-Brown E, Roifman CM. Cerebral vasculitis associated with chronic mucocutaneous candidiasis. J Pediatr. 1998 Oct; 133(4):571-4. PMID: 9787702.
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    151. Dalal I, Reid B, Nisbet-Brown E, Roifman CM. The outcome of patients with hypogammaglobulinemia in infancy and early childhood. J Pediatr. 1998 Jul; 133(1):144-6. PMID: 9672529.
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    152. Jones NL, Roifman CM, Griffiths AM, Sherman P. Ketotifen therapy for acute ulcerative colitis in children: a pilot study. Dig Dis Sci. 1998 Mar; 43(3):609-15. PMID: 9539658.
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    153. Dalal I, Arpaia E, Dadi H, Kulkarni S, Squire J, Roifman CM. Cloning and characterization of the human homolog of mouse Jak2. Blood. 1998 Feb 01; 91(3):844-51. PMID: 9446644.
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    154. Arrendondo-Vega FX, Santisteban I, Notarangelo LD, El Dahr J, Buckley R, Roifman C, Conley ME, Hershfield MS. Seven novel mutations in the adenosine deaminase (ADA) gene in patients with severe and delayed onset combined immunodeficiency: G74C, V129M, G140E, R149W, Q199P, 462delG, and E337del. Mutations in brief no. 142. Online. Hum Mutat. 1998; 11(6):482. PMID: 10200056.
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    155. Sharfe N, Shahar M, Roifman CM. An interleukin-2 receptor gamma chain mutation with normal thymus morphology. J Clin Invest. 1997 Dec 15; 100(12):3036-43. PMID: 9399950.
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    156. Manson D, Reid B, Dalal I, Roifman CM. Clinical utility of high-resolution pulmonary computed tomography in children with antibody deficiency disorders. Pediatr Radiol. 1997 Oct; 27(10):794-8. PMID: 9323243.
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    157. Loebstein R, Dalal I, Nisbet-Brown E, Berkovitch M, Meydan N, Andrews D, Loubser MD, Koren G, Roifman CM, Olivieri NF. Immune function in patients with beta thalassaemia receiving the orally active iron-chelating agent deferiprone. Br J Haematol. 1997 Sep; 98(3):597-600. PMID: 9332313.
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    158. Sharfe N, Roifman CM. Differential association of phosphatidylinositol 3-kinase with insulin receptor substrate (IRS)-1 and IRS-2 in human thymocytes in response to IL-7. J Immunol. 1997 Aug 01; 159(3):1107-14. PMID: 9233603.
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    159. Sharfe N, Dadi HK, O'Shea JJ, Roifman CM. Jak3 activation in human lymphocyte precursor cells. Clin Exp Immunol. 1997 Jun; 108(3):552-6. PMID: 9182906.
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    160. Nadarajah S, Krafchik B, Roifman C, Horgan-Bell C. Treatment of hypereosinophilic syndrome in a child using cyclosporine: implication for a primary T-cell abnormality. Pediatrics. 1997 Apr; 99(4):630-3. PMID: 9093318.
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    161. Sharfe N, Dadi HK, Shahar M, Roifman CM. Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor. Proc Natl Acad Sci U S A. 1997 Apr 01; 94(7):3168-71. PMID: 9096364.
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    162. Shahar E, Shorer Z, Roifman CM, Levi Y, Brand N, Ravid S, Murphy EG. Immune globulins are effective in severe pediatric Guillain-Barré syndrome. Pediatr Neurol. 1997 Jan; 16(1):32-6. PMID: 9044398.
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    163. Messner AH, Mitchell DP, Roifman CM. Mucosal lesions in severe combined immunodeficiency syndrome. J Otolaryngol. 1996 Jun; 25(3):200-2. PMID: 8783087.
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    164. Meydan N, Grunberger T, Dadi H, Shahar M, Arpaia E, Lapidot Z, Leeder JS, Freedman M, Cohen A, Gazit A, Levitzki A, Roifman CM. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature. 1996 Feb 15; 379(6566):645-8. PMID: 8628398.
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    165. Santisteban I, Arredondo-Vega FX, Kelly S, Loubser M, Meydan N, Roifman C, Howell PL, Bowen T, Weinberg KI, Schroeder ML, et al. Three new adenosine deaminase mutations that define a splicing enhancer and cause severe and partial phenotypes: implications for evolution of a CpG hotspot and expression of a transduced ADA cDNA. Hum Mol Genet. 1995 Nov; 4(11):2081-7. PMID: 8589684.
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    166. Roifman CM. Use of intravenous immune globulin in the therapy of children with rheumatological diseases. J Clin Immunol. 1995 Nov; 15(6 Suppl):42S-51S. PMID: 8613492.
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    167. Roifman CM. A mutation in zap-70 protein tyrosine kinase results in a selective immunodeficiency. J Clin Immunol. 1995 Nov; 15(6 Suppl):52S-62S. PMID: 8613493.
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    168. Trink B, Wang G, Shahar M, Meydan N, Roifman CM. Functional platelet-derived growth factor-beta (PDGF-beta) receptor expressed on early B-lineage precursor cells. Clin Exp Immunol. 1995 Nov; 102(2):417-24. PMID: 7586700.
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    169. Sharfe N, Dadi HK, Roifman CM. JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3' kinase. Blood. 1995 Sep 15; 86(6):2077-85. PMID: 7662955.
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    170. Stein LD, Roifman CM. Intravenous immunoglobulin therapy. Bull Rheum Dis. 1995 Jun; 44(4):3-5. PMID: 7787963.
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    171. Gaspar HB, Bradley LA, Katz F, Lovering RC, Roifman CM, Morgan G, Levinsky RJ, Kinnon C. Mutation analysis in Bruton's tyrosine kinase, the X-linked agammaglobulinaemia gene, including identification of an insertional hotspot. Hum Mol Genet. 1995 Apr; 4(4):755-7. PMID: 7633429.
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    172. Roifman CM. Selection transduction defect (STD) due to Zap-70 kinase deficiency. Immunodeficiency. 1995; 5(3):193-211. PMID: 7749439.
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    173. Dadi H, Ke S, Roifman CM. Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity. Blood. 1994 Sep 01; 84(5):1579-86. PMID: 7520779.
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    174. Melamed I, Stein L, Roifman CM. Epstein-Barr virus induces actin polymerization in human B cells. J Immunol. 1994 Sep 01; 153(5):1998-2003. PMID: 8051404.
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    175. Cohen AJ, Roifman C, Brendan J, Mullen M, Reid B, Weisbrod G, Downey GP. Localised pulmonary resection for bronchiectasis in hypogammaglobulinaemic patients. Thorax. 1994 May; 49(5):509-10. PMID: 8016776.
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    176. Chirmule N, Wang XP, Hu R, Oyaizu N, Roifman C, Pahwa R, Kalyanaraman VS, Pahwa S. Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help. Cell Immunol. 1994 Apr 15; 155(1):169-82. PMID: 8168144.
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    177. Arpaia E, Shahar M, Dadi H, Cohen A, Roifman CM. Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase. Cell. 1994 Mar 11; 76(5):947-58. PMID: 8124727.
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    178. Shpitz B, Chambers CA, Singhal AB, Hozumi N, Fernandes BJ, Roifman CM, Weiner LM, Roder JC, Gallinger S. High level functional engraftment of severe combined immunodeficient mice with human peripheral blood lymphocytes following pretreatment with radiation and anti-asialo GM1. J Immunol Methods. 1994 Feb 28; 169(1):1-15. PMID: 7907638.
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    179. Melamed I, Cohen A, Roifman CM. Expansion of CD3+CD4-CD8- T cell population expressing high levels of IL-5 in Omenn's syndrome. Clin Exp Immunol. 1994 Jan; 95(1):14-21. PMID: 8287598.
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    180. Dadi HK, Roifman CM. Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor on human thymocytes. J Clin Invest. 1993 Sep; 92(3):1559-63. PMID: 8397227.
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    181. Roifman CM, Ke S. CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells. Biochem Biophys Res Commun. 1993 Jul 15; 194(1):222-5. PMID: 7687428.
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    182. Dadi HK, Ke S, Roifman CM. Interleukin 7 receptor mediates the activation of phosphatidylinositol-3 kinase in human B-cell precursors. Biochem Biophys Res Commun. 1993 Apr 30; 192(2):459-64. PMID: 8387278.
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    183. Roifman CM, Wang G. Receptor-mediated activation of human B lymphocytes in a nonphosphotyrosine-dependent manner. J Immunol. 1992 Aug 15; 149(4):1179-84. PMID: 1380035.
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    184. Melamed I, Wang G, Roifman CM. Antigen receptor-mediated protein tyrosine kinase activity is regulated by a pertussis toxin-sensitive G protein. J Immunol. 1992 Jul 01; 149(1):169-74. PMID: 1376748.
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    185. Roifman CM, Wang G. Phospholipase C-gamma 1 and phospholipase C-gamma 2 are substrates of the B cell antigen receptor associated protein tyrosine kinase. Biochem Biophys Res Commun. 1992 Mar 16; 183(2):411-6. PMID: 1550550.
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    186. Roifman CM, Wang GX, Freedman M, Pan ZQ. IL-7 receptor mediates tyrosine phosphorylation but does not activate the phosphatidylinositol-phospholipase C-gamma 1 pathway. J Immunol. 1992 Feb 15; 148(4):1136-42. PMID: 1531350.
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    187. Schneider R, Lang BA, Reilly BJ, Laxer RM, Silverman ED, Ibanez D, Bombardier C, Roifman CM. Prognostic indicators of joint destruction in systemic-onset juvenile rheumatoid arthritis. J Pediatr. 1992 Feb; 120(2 Pt 1):200-5. PMID: 1735815.
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    188. Melamed I, Griffiths AM, Roifman CM. Benefit of oral immune globulin therapy in patients with immunodeficiency and chronic diarrhea. J Pediatr. 1991 Sep; 119(3):486-9. PMID: 1880668.
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    189. Melamed I, Downey GP, Aktories K, Roifman CM. Microfilament assembly is required for antigen-receptor-mediated activation of human B lymphocytes. J Immunol. 1991 Aug 15; 147(4):1139-46. PMID: 1907989.
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    190. Lang BA, Laxer RM, Murphy G, Silverman ED, Roifman CM. Treatment of dermatomyositis with intravenous gammaglobulin. Am J Med. 1991 Aug; 91(2):169-72. PMID: 1714236.
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    191. Cohen A, Grunberger T, Vanek W, Dube ID, Doherty PJ, Letarte M, Roifman C, Freedman MH. Constitutive expression and role in growth regulation of interleukin-1 and multiple cytokine receptors in a biphenotypic leukemic cell line. Blood. 1991 Jul 01; 78(1):94-102. PMID: 1648979.
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    192. Doherty PJ, Roifman CM, Pan SH, Cymerman U, Ho SW, Thompson E, Kamel-Reid S, Cohen A. Expression of the human T cell receptor V beta repertoire. Mol Immunol. 1991 Jun; 28(6):607-12. PMID: 1830638.
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    193. Stein R, Hummel D, Bohn D, Levison H, Roifman CM. Lymphocytic pneumonitis following bone marrow transplantation in severe combined immunodeficiency. Am Rev Respir Dis. 1991 Jun; 143(6):1406-8. PMID: 2048828.
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    194. Melamed I, Downey GP, Roifman CM. Tyrosine phosphorylation is essential for microfilament assembly in B lymphocytes. Biochem Biophys Res Commun. 1991 May 15; 176(3):1424-9. PMID: 2039521.
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    195. Roifman CM, Chin K, Gazit A, Mills GB, Gilon C, Levitzki A. Tyrosine phosphorylation is an essential event in the stimulation of B lymphocytes by Staphylococcus aureus Cowan I. J Immunol. 1991 May 01; 146(9):2965-71. PMID: 1707926.
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    196. Olivieri NF, Koren G, Freedman MH, Roifman C. Rarity of systemic lupus erythematosus after oral iron chelator L1. Lancet. 1991 Apr 13; 337(8746):924. PMID: 1673008.
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    197. Doherty PJ, Pan S, Mulloy JC, Thompson E, Thorner P, Barankiewiecz J, Roifman CM, Cohen A. Adenosine deaminase and thymocyte maturation. Scand J Immunol. 1991 Apr; 33(4):405-10. PMID: 1826794.
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    198. Padeh S, Cohen A, Roifman CM. ATP-induced activation of human B lymphocytes via P2-purinoceptors. J Immunol. 1991 Mar 01; 146(5):1626-32. PMID: 1847168.
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    199. Padeh S, Levitzki A, Gazit A, Mills GB, Roifman CM. Activation of phospholipase C in human B cells is dependent on tyrosine phosphorylation. J Clin Invest. 1991 Mar; 87(3):1114-8. PMID: 1705565.
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    200. Melamed I, Feanny SJ, Sherman PM, Roifman CM. Benefit of ketotifen in patients with eosinophilic gastroenteritis. Am J Med. 1991 Mar; 90(3):310-4. PMID: 2003512.
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    201. Foskett JK, Roifman CM, Wong D. Activation of calcium oscillations by thapsigargin in parotid acinar cells. J Biol Chem. 1991 Feb 15; 266(5):2778-82. PMID: 1847134.
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    202. Xiang JH, Roder J, Pan ZG, Roifman C, Hozumi N. Modification in framework region I results in a decreased affinity of chimeric anti-TAG72 antibody. Mol Immunol. 1991 Jan-Feb; 28(1-2):141-8. PMID: 2011123.
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    203. Binkley K, Shore A, Buncic R, Roifman CM. Acquired Brown's syndrome associated with hypogammaglobulinemia. J Rheumatol. 1991 Jan; 18(1):139-41. PMID: 2023184.
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    204. Bentur L, Nisbet-Brown E, Levison H, Roifman CM. Lung disease associated with IgG subclass deficiency in chronic mucocutaneous candidiasis. J Pediatr. 1991 Jan; 118(1):82-6. PMID: 1986107.
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    205. Bentur L, McKlusky I, Levison H, Roifman CM. Advanced lung disease in a patient with cystic fibrosis and hypogammaglobulinemia: response to intravenous immune globulin therapy. J Pediatr. 1990 Nov; 117(5):741-3. PMID: 2231205.
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    206. Silverman ED, Laxer RM, Greenwald M, Gelfand E, Shore A, Stein LD, Roifman CM. Intravenous gamma globulin therapy in systemic juvenile rheumatoid arthritis. Arthritis Rheum. 1990 Jul; 33(7):1015-22. PMID: 1695098.
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    207. Conley ME, Buckley RH, Hong R, Guerra-Hanson C, Roifman CM, Brochstein JA, Pahwa S, Puck JM. X-linked severe combined immunodeficiency. Diagnosis in males with sporadic severe combined immunodeficiency and clarification of clinical findings. J Clin Invest. 1990 May; 85(5):1548-54. PMID: 2332505.
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    208. Shahar E, Murphy EG, Roifman CM. Benefit of intravenously administered immune serum globulin in patients with Guillain-Barré syndrome. J Pediatr. 1990 Jan; 116(1):141-4. PMID: 2295955.
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    209. Bentur L, Shear N, Roifman CM. Cutaneous lymphohistiocytic infiltrates in patients with hypogammaglobulinemia. J Pediatr. 1990 Jan; 116(1):68-72. PMID: 2295965.
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    210. Roifman CM, Hummel D, Martinez-Valdez H, Thorner P, Doherty PJ, Pan S, Cohen F, Cohen A. Depletion of CD8+ cells in human thymic medulla results in selective immune deficiency. J Exp Med. 1989 Dec 01; 170(6):2177-82. PMID: 2511270.
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    211. Mills GB, May C, Hill M, Ebanks R, Roifman C, Mellors A, Gelfand EW. Physiologic activation of protein kinase C limits IL-2 secretion. J Immunol. 1989 Mar 15; 142(6):1995-2003. PMID: 2784146.
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    212. Ebanks R, Roifman C, Mellors A, Mills GB. The diacylglycerol analogue, 1,2-sn-dioctanoylglycerol, induces an increase in cytosolic free Ca2+ and cytosolic acidification of T lymphocytes through a protein kinase C-independent process. Biochem J. 1989 Mar 15; 258(3):689-98. PMID: 2786413.
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    213. Bentur Y, Hummel D, Roifman CM, Giesbrecht E, Koren G. Interpretation of excessive levels of inhaled tobramycin. Ther Drug Monit. 1989; 11(1):109-10. PMID: 2911844.
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    214. Canny GJ, Roifman C, Weitzman S, Braudo M, Levison H. A pulmonary infiltrate in a child with ataxia telangiectasia. Ann Allergy. 1988 Dec; 61(6):422-3, 466-8. PMID: 3202332.
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    215. Tisch R, Roifman CM, Hozumi N. Functional differences between immunoglobulins M and D expressed on the surface of an immature B-cell line. Proc Natl Acad Sci U S A. 1988 Sep; 85(18):6914-8. PMID: 3137579.
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    216. Roifman CM, Gelfand EW. Replacement therapy with high dose intravenous gamma-globulin improves chronic sinopulmonary disease in patients with hypogammaglobulinemia. Pediatr Infect Dis J. 1988 May; 7(5 Suppl):S92-6. PMID: 3399285.
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    217. Mills GB, May C, McGill M, Roifman CM, Mellors A. A putative new growth factor in ascitic fluid from ovarian cancer patients: identification, characterization, and mechanism of action. Cancer Res. 1988 Mar 01; 48(5):1066-71. PMID: 3422589.
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    218. Gelfand EW, Reid B, Roifman CM. Intravenous immune serum globulin replacement in hypogammaglobulinemia. A comparison of high- versus low-dose therapy. Monogr Allergy. 1988; 23:177-86. PMID: 3386639.
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    219. Roifman CM, Mills GB, Stewart D, Cheung RK, Grinstein S, Gelfand EW. Response of human B cells to different anti-immunoglobulin isotypes: absence of a correlation between early activation events and cell proliferation. Eur J Immunol. 1987 Dec; 17(12):1737-42. PMID: 3500860.
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    220. Roifman CM, Schaffer FM, Wachsmuth SE, Murphy G, Gelfand EW. Reversal of chronic polymyositis following intravenous immune serum globulin therapy. JAMA. 1987 Jul 24-31; 258(4):513-5. PMID: 3599350.
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    221. Koren G, Roifman C, Gelfand E, Lavi S, Suria D, Stein L. Corticosteroids-salicylate interaction in a case of juvenile rheumatoid arthritis. Ther Drug Monit. 1987 Jun; 9(2):177-9. PMID: 3617157.
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    222. Roifman CM, Levison H, Gelfand EW. High-dose versus low-dose intravenous immunoglobulin in hypogammaglobulinaemia and chronic lung disease. Lancet. 1987 May 09; 1(8541):1075-7. PMID: 2883406.
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    223. Roifman CM, Benedict SH, Cheung RK, Gelfand EW. Induction of human B cell proliferation and differentiation by the combination of phorbol ester and ionomycin. Eur J Immunol. 1987 May; 17(5):701-6. PMID: 3495445.
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    224. Estrov Z, Roifman C, Mills G, Grunberger T, Gelfand EW, Freedman MH. The regulatory role of interleukin 2-responsive T lymphocytes on human marrow granulopoiesis. Blood. 1987 Apr; 69(4):1161-6. PMID: 3103713.
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    225. Roifman CM, Mills GB, Cheung RK, Gelfand EW. Mitogenic response of human thymocytes: identification of functional Ca2+-dependent and independent signals. Clin Exp Immunol. 1986 Oct; 66(1):139-49. PMID: 3100117.
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    226. Lederman HM, Roifman CM, Lavi S, Gelfand EW. Corticosteroids for prevention of adverse reactions to intravenous immune serum globulin infusions in hypogammaglobulinemic patients. Am J Med. 1986 Sep; 81(3):443-6. PMID: 3752145.
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    227. Estrov Z, Roifman C, Wang YP, Grunberger T, Gelfand EW, Freedman MH. The regulatory role of interleukin 2-responsive T lymphocytes on early and mature erythroid progenitor proliferation. Blood. 1986 Jun; 67(6):1607-10. PMID: 3486684.
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    228. Roifman CM, Rao CP, Lederman HM, Lavi S, Quinn P, Gelfand EW. Increased susceptibility to Mycoplasma infection in patients with hypogammaglobulinemia. Am J Med. 1986 Apr; 80(4):590-4. PMID: 3963038.
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    229. Roifman CM, Mills GB, Chu M, Gelfand EW. Functional comparison of recombinant interleukin 2 (IL-2) with IL-2-containing preparations derived from cultured cells. Cell Immunol. 1985 Oct 01; 95(1):146-56. PMID: 3875424.
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    230. Roifman CM, Lederman HM, Lavi S, Stein LD, Levison H, Gelfand EW. Benefit of intravenous IgG replacement in hypogammaglobulinemic patients with chronic sinopulmonary disease. Am J Med. 1985 Aug; 79(2):171-4. PMID: 4025374.
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    231. Koren G, Lavi S, Greenwald M, Roifman C, Leeder JS, Gelfand EW, MacLeod SM. Cerebrospinal fluid pharmacokinetics of tobramycin, ceftazidime, phenobarbitone and phenytoin in a child. Clin Pharmacokinet. 1985 Jul-Aug; 10(4):371-5. PMID: 3899453.
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    232. Roifman CM, Lavi S, Moore AT, Morin DJ, Stein LD, Gelfand EW. Tenosynovitis of the superior oblique muscle (Brown syndrome) associated with juvenile rheumatoid arthritis. J Pediatr. 1985 Apr; 106(4):617-9. PMID: 3981317.
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    233. Roifman CM, Gelfand EW. Heterogeneity of the immunological deficiency in ataxia-telangiectasia: absence of a clinical-pathological correlation. Kroc Found Ser. 1985; 19:273-85. PMID: 3877786.
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    234. Roifman C, Dembo L, Grenadier E, Margolis T, Palant A, Iancu TC. Sinus node dysfunction in a healthy pediatric population. Isr J Med Sci. 1984 Jun; 20(6):497-500. PMID: 6469571.
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    235. Roifman CM, Eytan GD, Iancu TC. Ferritin--phospholipid interaction: a model system for intralysosomal ferritin segregation in iron-overloaded hepatocytes. J Ultrastruct Res. 1982 Jun; 79(3):307-13. PMID: 7086949.
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