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Aleksander Hinek

TitleSenior Scientist
InstitutionThe Hospital for Sick Children
DepartmentTranslational Medicine
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mao S, Taylor S, Chen Q, Zhang M, Hinek A. Sodium tanshinone IIA sulfonate prevents the adverse left ventricular remodelling: Focus on polymorphonuclear neutrophil-derived granule components. J Cell Mol Med. 2019 Jul; 23(7):4592-4600. PMID: 31066232.
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    2. Brassart B, Da Silva J, Donet M, Seurat E, Hague F, Terryn C, Velard F, Michel J, Ouadid-Ahidouch H, Monboisse JC, Hinek A, Maquart FX, Ramont L, Brassart-Pasco S. Tumour cell blebbing and extracellular vesicle shedding: key role of matrikines and ribosomal protein SA. Br J Cancer. 2019 Feb; 120(4):453-465. PMID: 30739912.
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    3. Tew BY, Legendre C, Gooden GC, Johnson KN, Martinez RA, Kiefer J, Bernstein M, Glen J, Butry L, Hinek A, Toms SA, Salhia B. Isolation and characterization of patient-derived CNS metastasis-associated stromal cell lines. Oncogene. 2019 May; 38(21):4002-4014. PMID: 30700832.
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    4. Sun M, Ishii R, Okumura K, Krauszman A, Breitling S, Gomez O, Hinek A, Boo S, Hinz B, Connelly KA, Kuebler WM, Friedberg MK. Experimental Right Ventricular Hypertension Induces Regional ß1-Integrin-Mediated Transduction of Hypertrophic and Profibrotic Right and Left Ventricular Signaling. J Am Heart Assoc. 2018 Mar 29; 7(7). PMID: 29599211.
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    5. Pan X, Wang Y, Lübke T, Hinek A, Pshezhetsky AV. Mice, double deficient in lysosomal serine carboxypeptidases Scpep1 and Cathepsin A develop the hyperproliferative vesicular corneal dystrophy and hypertrophic skin thickenings. PLoS One. 2017; 12(2):e0172854. PMID: 28234994.
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    6. Mao S, Wang L, Ouyang W, Zhou Y, Qi J, Guo L, Zhang M, Hinek A. Traditional Chinese medicine, Danlou tablets alleviate adverse left ventricular remodeling after myocardial infarction: results of a double-blind, randomized, placebo-controlled, pilot study. BMC Complement Altern Med. 2016 Nov 08; 16(1):447. PMID: 27825334.
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    7. Qa'aty N, Vincent M, Wang Y, Wang A, Mitts TF, Hinek A. Synthetic ligands of the elastin receptor induce elastogenesis in human dermal fibroblasts via activation of their IGF-1 receptors. J Dermatol Sci. 2015 Dec; 80(3):175-85. PMID: 26475432.
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    8. Mao S, Li W, Qa'aty N, Vincent M, Zhang M, Hinek A. Tanshinone IIA inhibits angiotensin II induced extracellular matrix remodeling in human cardiac fibroblasts--Implications for treatment of pathologic cardiac remodeling. Int J Cardiol. 2016 Jan 01; 202:110-7. PMID: 26408838.
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    9. Mao S, Wang L, Zhao X, Shang H, Zhang M, Hinek A. Sodium tanshinone IIA sulfonate for reduction of periprocedural myocardial injury during percutaneous coronary intervention (STAMP trial): rationale and design. Int J Cardiol. 2015 Mar 01; 182:329-33. PMID: 25585378.
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    10. Qa'aty N, Wang Y, Wang A, Mao S, Vincent M, Husain M, Hinek A. The antidiabetic hormone glucagon-like peptide-1 induces formation of new elastic fibers in human cardiac fibroblasts after cross-activation of IGF-IR. Endocrinology. 2015 Jan; 156(1):90-102. PMID: 25353182.
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    11. Reich A, Bae AS, Barnes AM, Cabral WA, Hinek A, Stimec J, Hill SC, Chitayat D, Marini JC. Type V OI primary osteoblasts display increased mineralization despite decreased COL1A1 expression. J Clin Endocrinol Metab. 2015 Feb; 100(2):E325-32. PMID: 25387264.
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    12. Hinek A, Kim HJ, Wang Y, Wang A, Mitts TF. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep; 75(3):173-82. PMID: 25015208.
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    13. Pan X, Grigoryeva L, Seyrantepe V, Peng J, Kollmann K, Tremblay J, Lavoie JL, Hinek A, Lübke T, Pshezhetsky AV. Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1. PLoS Genet. 2014 Feb; 10(2):e1004146. PMID: 24586188.
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    14. Mao S, Wang Y, Zhang M, Hinek A. Phytoestrogen, tanshinone IIA diminishes collagen deposition and stimulates new elastogenesis in cultures of human cardiac fibroblasts. Exp Cell Res. 2014 Apr 15; 323(1):189-97. PMID: 24525372.
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    15. Chung BH, Bradley T, Grosse-Wortmann L, Blaser S, Dirks P, Hinek A, Chitayat D. Hand and fibrillin-1 deposition abnormalities in Loeys-Dietz syndrome--expanding the clinical spectrum. Am J Med Genet A. 2014 Feb; 164A(2):461-6. PMID: 24194458.
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    16. Kinnear C, Chang WY, Khattak S, Hinek A, Thompson T, de Carvalho Rodrigues D, Kennedy K, Mahmut N, Pasceri P, Stanford WL, Ellis J, Mital S. Modeling and rescue of the vascular phenotype of Williams-Beuren syndrome in patient induced pluripotent stem cells. Stem Cells Transl Med. 2013 Jan; 2(1):2-15. PMID: 23283491.
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    17. Chung B, Hinek A, Keating S, Weksberg R, Shah V, Blaser S, Hawkins C, Chitayat D. Overgrowth with increased proliferation of fibroblast and matrix metalloproteinase activity related to reduced TIMP1: a newly recognized syndrome? Am J Med Genet A. 2012 Oct; 158A(10):2373-81. PMID: 22965799.
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    18. Traister A, Aafaqi S, Masse S, Dai X, Li M, Hinek A, Nanthakumar K, Hannigan G, Coles JG. ILK induces cardiomyogenesis in the human heart. PLoS One. 2012; 7(5):e37802. PMID: 22666394.
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    19. Mendoza-Londono R, Chitayat D, Kahr WH, Hinek A, Blaser S, Dupuis L, Goh E, Badilla-Porras R, Howard A, Mittaz L, Superti-Furga A, Unger S, Nishimura G, Bonafe L. Extracellular matrix and platelet function in patients with musculocontractural Ehlers-Danlos syndrome caused by mutations in the CHST14 gene. Am J Med Genet A. 2012 Jun; 158A(6):1344-54. PMID: 22581468.
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    20. Klüppel M, Samavarchi-Tehrani P, Liu K, Wrana JL, Hinek A. C4ST-1/CHST11-controlled chondroitin sulfation interferes with oncogenic HRAS signaling in Costello syndrome. Eur J Hum Genet. 2012 Aug; 20(8):870-7. PMID: 22317973.
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    21. Lehman A, Mattman A, Sin D, Pare P, Zong Z, d'Azzo A, Campos Y, Sirrs S, Hinek A. Emphysema in an adult with galactosialidosis linked to a defect in primary elastic fiber assembly. Mol Genet Metab. 2012 May; 106(1):99-103. PMID: 22386972.
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    22. Shi J, Wang A, Sen S, Wang Y, Kim HJ, Mitts TF, Hinek A. Insulin induces production of new elastin in cultures of human aortic smooth muscle cells. Am J Pathol. 2012 Feb; 180(2):715-26. PMID: 22236491.
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    23. Skeie JM, Hernandez J, Hinek A, Mullins RF. Molecular responses of choroidal endothelial cells to elastin derived peptides through the elastin-binding protein (GLB1). Matrix Biol. 2012 Mar; 31(2):113-9. PMID: 22178079.
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    24. Pshezhetsky AV, Hinek A. Where catabolism meets signalling: neuraminidase 1 as a modulator of cell receptors. Glycoconj J. 2011 Oct; 28(7):441-52. PMID: 21928149.
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    25. Sen S, Bunda S, Shi J, Wang A, Mitts TF, Hinek A. Retinoblastoma protein modulates the inverse relationship between cellular proliferation and elastogenesis. J Biol Chem. 2011 Oct 21; 286(42):36580-91. PMID: 21880723.
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    26. Merrilees MJ, Beaumont BW, Braun KR, Thomas AC, Kang I, Hinek A, Passi A, Wight TN. Neointima formed by arterial smooth muscle cells expressing versican variant V3 is resistant to lipid and macrophage accumulation. Arterioscler Thromb Vasc Biol. 2011 Jun; 31(6):1309-16. PMID: 21441139.
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    27. Barnett CP, Chitayat D, Bradley TJ, Wang Y, Hinek A. Dexamethasone normalizes aberrant elastic fiber production and collagen 1 secretion by Loeys-Dietz syndrome fibroblasts: a possible treatment? Eur J Hum Genet. 2011 Jun; 19(6):624-33. PMID: 21267002.
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    28. Murphy BA, Bunda S, Mitts T, Hinek A. The hyperthermia-enhanced association between tropoelastin and its 67-kDa chaperone results in better deposition of elastic fibers. J Biol Chem. 2010 Dec 17; 285(51):40282-93. PMID: 20947500.
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    29. Barnett CP, Wilson GJ, Chiasson DA, Gross GJ, Hinek A, Hawkins C, Chitayat D. Central nervous system abnormalities in two cases with neonatal Marfan syndrome with novel mutations in the fibrillin-1 gene. Am J Med Genet A. 2010 Sep; 152A(9):2409-12. PMID: 20803651.
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    30. Mitts TF, Bunda S, Wang Y, Hinek A. Aldosterone and mineralocorticoid receptor antagonists modulate elastin and collagen deposition in human skin. J Invest Dermatol. 2010 Oct; 130(10):2396-406. PMID: 20535129.
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    31. Arabkhari M, Bunda S, Wang Y, Wang A, Pshezhetsky AV, Hinek A. Desialylation of insulin receptors and IGF-1 receptors by neuraminidase-1 controls the net proliferative response of L6 myoblasts to insulin. Glycobiology. 2010 May; 20(5):603-16. PMID: 20100694.
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    32. Arribas SM, Hermida C, González MC, Wang Y, Hinek A. Enhanced survival of vascular smooth muscle cells accounts for heightened elastin deposition in arteries of neonatal spontaneously hypertensive rats. Exp Physiol. 2010 Apr; 95(4):550-60. PMID: 20008031.
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    33. Chen Q, Zhang T, Roshetsky JF, Ouyang Z, Essers J, Fan C, Wang Q, Hinek A, Plow EF, Dicorleto PE. Fibulin-4 regulates expression of the tropoelastin gene and consequent elastic-fibre formation by human fibroblasts. Biochem J. 2009 Sep 14; 423(1):79-89. PMID: 19627254.
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    34. Barnett C, Langer JC, Hinek A, Bradley TJ, Chitayat D. Looking past the lump: genetic aspects of inguinal hernia in children. J Pediatr Surg. 2009 Jul; 44(7):1423-31. PMID: 19573673.
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    35. Bunda S, Wang Y, Mitts TF, Liu P, Arab S, Arabkhari M, Hinek A. Aldosterone stimulates elastogenesis in cardiac fibroblasts via mineralocorticoid receptor-independent action involving the consecutive activation of Galpha13, c-Src, the insulin-like growth factor-I receptor, and phosphatidylinositol 3-kinase/Akt. J Biol Chem. 2009 Jun 12; 284(24):16633-47. PMID: 19372600.
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    36. Lee KJ, Hinek A, Chaturvedi RR, Almeida CL, Honjo O, Koren G, Benson LN. Rapamycin-eluting stents in the arterial duct: experimental observations in the pig model. Circulation. 2009 Apr 21; 119(15):2078-85. PMID: 19349326.
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    37. Pshezhetsky AV, Hinek A. Serine carboxypeptidases in regulation of vasoconstriction and elastogenesis. Trends Cardiovasc Med. 2009 Jan; 19(1):11-7. PMID: 19467448.
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    38. Hwang JY, Johnson PY, Braun KR, Hinek A, Fischer JW, O'Brien KD, Starcher B, Clowes AW, Merrilees MJ, Wight TN. Retrovirally mediated overexpression of glycosaminoglycan-deficient biglycan in arterial smooth muscle cells induces tropoelastin synthesis and elastic fiber formation in vitro and in neointimae after vascular injury. Am J Pathol. 2008 Dec; 173(6):1919-28. PMID: 18988796.
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    39. Arribas SM, Briones AM, Bellingham C, González MC, Salaices M, Liu K, Wang Y, Hinek A. Heightened aberrant deposition of hard-wearing elastin in conduit arteries of prehypertensive SHR is associated with increased stiffness and inward remodeling. Am J Physiol Heart Circ Physiol. 2008 Dec; 295(6):H2299-307. PMID: 18849339.
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    40. Hinek A, Jain S, Taylor G, Nykanen D, Chitayat D. High copper levels and increased elastolysis in a patient with cutis marmorata teleangiectasia congenita. Am J Med Genet A. 2008 Oct 01; 146A(19):2520-7. PMID: 18792971.
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    41. Hinek A, Bodnaruk TD, Bunda S, Wang Y, Liu K. Neuraminidase-1, a subunit of the cell surface elastin receptor, desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2. Am J Pathol. 2008 Oct; 173(4):1042-56. PMID: 18772331.
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    42. Lelièvre E, Hinek A, Lupu F, Buquet C, Soncin F, Mattot V. VE-statin/egfl7 regulates vascular elastogenesis by interacting with lysyl oxidases. EMBO J. 2008 Jun 18; 27(12):1658-70. PMID: 18497746.
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    43. Merrilees MJ, Ching PS, Beaumont B, Hinek A, Wight TN, Black PN. Changes in elastin, elastin binding protein and versican in alveoli in chronic obstructive pulmonary disease. Respir Res. 2008 May 18; 9:41. PMID: 18485243.
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    44. Rauen KA, Hefner E, Carrillo K, Taylor J, Messier L, Aoki Y, Gripp KW, Matsubara Y, Proud VK, Hammond P, Allanson JE, Delrue MA, Axelrad ME, Lin AE, Doyle DA, Kerr B, Carey JC, McCormick F, Silva AJ, Kieran MW, Hinek A, Nguyen TT, Schoyer L. Molecular aspects, clinical aspects and possible treatment modalities for Costello syndrome: Proceedings from the 1st International Costello Syndrome Research Symposium 2007. Am J Med Genet A. 2008 May 01; 146A(9):1205-17. PMID: 18412122.
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    45. Seyrantepe V, Hinek A, Peng J, Fedjaev M, Ernest S, Kadota Y, Canuel M, Itoh K, Morales CR, Lavoie J, Tremblay J, Pshezhetsky AV. Enzymatic activity of lysosomal carboxypeptidase (cathepsin) A is required for proper elastic fiber formation and inactivation of endothelin-1. Circulation. 2008 Apr 15; 117(15):1973-81. PMID: 18391110.
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    46. Kontaridis MI, Yang W, Bence KK, Cullen D, Wang B, Bodyak N, Ke Q, Hinek A, Kang PM, Liao R, Neel BG. Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways. Circulation. 2008 Mar 18; 117(11):1423-35. PMID: 18316486.
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    47. Bunda S, Liu P, Wang Y, Liu K, Hinek A. Aldosterone induces elastin production in cardiac fibroblasts through activation of insulin-like growth factor-I receptors in a mineralocorticoid receptor-independent manner. Am J Pathol. 2007 Sep; 171(3):809-19. PMID: 17724138.
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    48. Hill CH, Ashwell CM, Nolin SJ, Keeley F, Billingham C, Hinek A, Starcher B. Dietary iron deficiency compromises normal development of elastic fibers in the aorta and lungs of chicks. J Nutr. 2007 Aug; 137(8):1895-900. PMID: 17634261.
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    49. Duca L, Blanchevoye C, Cantarelli B, Ghoneim C, Dedieu S, Delacoux F, Hornebeck W, Hinek A, Martiny L, Debelle L. The elastin receptor complex transduces signals through the catalytic activity of its Neu-1 subunit. J Biol Chem. 2007 Apr 27; 282(17):12484-91. PMID: 17327233.
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    50. Lu H, Fedak PW, Dai X, Du C, Zhou YQ, Henkelman M, Mongroo PS, Lau A, Yamabi H, Hinek A, Husain M, Hannigan G, Coles JG. Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice. Circulation. 2006 Nov 21; 114(21):2271-9. PMID: 17088456.
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    51. Jimenez F, Mitts TF, Liu K, Wang Y, Hinek A. Ellagic and tannic acids protect newly synthesized elastic fibers from premature enzymatic degradation in dermal fibroblast cultures. J Invest Dermatol. 2006 Jun; 126(6):1272-80. PMID: 16601672.
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    52. Le Saux O, Bunda S, VanWart CM, Douet V, Got L, Martin L, Hinek A. Serum factors from pseudoxanthoma elasticum patients alter elastic fiber formation in vitro. J Invest Dermatol. 2006 Jul; 126(7):1497-505. PMID: 16543900.
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    53. Arribas SM, Hinek A, González MC. Elastic fibres and vascular structure in hypertension. Pharmacol Ther. 2006 Sep; 111(3):771-91. PMID: 16488477.
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    54. Huang R, Merrilees MJ, Braun K, Beaumont B, Lemire J, Clowes AW, Hinek A, Wight TN. Inhibition of versican synthesis by antisense alters smooth muscle cell phenotype and induces elastic fiber formation in vitro and in neointima after vessel injury. Circ Res. 2006 Feb 17; 98(3):370-7. PMID: 16385080.
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    55. Hinek A, Pshezhetsky AV, von Itzstein M, Starcher B. Lysosomal sialidase (neuraminidase-1) is targeted to the cell surface in a multiprotein complex that facilitates elastic fiber assembly. J Biol Chem. 2006 Feb 10; 281(6):3698-710. PMID: 16314420.
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    56. Mitts TF, Jimenez F, Hinek A. Skin biopsy analysis reveals predisposition to stretch mark formation. Aesthet Surg J. 2005 Nov-Dec; 25(6):593-600. PMID: 19338863.
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    57. Hinek A, Wang Y, Liu K, Mitts TF, Jimenez F. Proteolytic digest derived from bovine Ligamentum Nuchae stimulates deposition of new elastin-enriched matrix in cultures and transplants of human dermal fibroblasts. J Dermatol Sci. 2005 Sep; 39(3):155-66. PMID: 15925490.
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    58. Merklinger SL, Wagner RA, Spiekerkoetter E, Hinek A, Knutsen RH, Kabir MG, Desai K, Hacker S, Wang L, Cann GM, Ambartsumian NS, Lukanidin E, Bernstein D, Husain M, Mecham RP, Starcher B, Yanagisawa H, Rabinovitch M. Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension. Circ Res. 2005 Sep 16; 97(6):596-604. PMID: 16109920.
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    59. Klüppel M, Wight TN, Chan C, Hinek A, Wrana JL. Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis. Development. 2005 Sep; 132(17):3989-4003. PMID: 16079159.
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    60. Hinek A, Teitell MA, Schoyer L, Allen W, Gripp KW, Hamilton R, Weksberg R, Klüppel M, Lin AE. Myocardial storage of chondroitin sulfate-containing moieties in Costello syndrome patients with severe hypertrophic cardiomyopathy. Am J Med Genet A. 2005 Feb 15; 133A(1):1-12. PMID: 15637729.
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    61. Bunda S, Kaviani N, Hinek A. Fluctuations of intracellular iron modulate elastin production. J Biol Chem. 2005 Jan 21; 280(3):2341-51. PMID: 15537639.
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    62. Hinek A, Braun KR, Liu K, Wang Y, Wight TN. Retrovirally mediated overexpression of versican v3 reverses impaired elastogenesis and heightened proliferation exhibited by fibroblasts from Costello syndrome and Hurler disease patients. Am J Pathol. 2004 Jan; 164(1):119-31. PMID: 14695326.
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    63. Mochizuki S, Brassart B, Hinek A. Signaling pathways transduced through the elastin receptor facilitate proliferation of arterial smooth muscle cells. J Biol Chem. 2002 Nov 22; 277(47):44854-63. PMID: 12244048.
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    64. Urbán Z, Riazi S, Seidl TL, Katahira J, Smoot LB, Chitayat D, Boyd CD, Hinek A. Connection between elastin haploinsufficiency and increased cell proliferation in patients with supravalvular aortic stenosis and Williams-Beuren syndrome. Am J Hum Genet. 2002 Jul; 71(1):30-44. PMID: 12016585.
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    65. Nakamura T, Lozano PR, Ikeda Y, Iwanaga Y, Hinek A, Minamisawa S, Cheng CF, Kobuke K, Dalton N, Takada Y, Tashiro K, Ross J, Honjo T, Chien KR. Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature. 2002 01 10; 415(6868):171-5. PMID: 11805835.
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    66. Masters J, Hinek AA, Uddin S, Platanias LC, Zeng W, McFadden G, Fish EN. Poxvirus infection rapidly activates tyrosine kinase signal transduction. J Biol Chem. 2001 Dec 21; 276(51):48371-5. PMID: 11591716.
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