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Jayne Danska

TitleSenior Scientist
InstitutionThe Hospital for Sick Children
DepartmentGenetics and Genome Biology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Paun A, Yau C, Meshkibaf S, Daigneault MC, Marandi L, Mortin-Toth S, Bar-Or A, Allen-Vercoe E, Poussier P, Danska JS. Association of HLA-dependent islet autoimmunity with systemic antibody responses to intestinal commensal bacteria in children. Sci Immunol. 2019 02 01; 4(32). PMID: 30709843.
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    2. Verdu EF, Danska JS. Common ground: shared risk factors for type 1 diabetes and celiac disease. Nat Immunol. 2018 07; 19(7):685-695. PMID: 29925984.
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    3. Dai H, Friday AJ, Abou-Daya KI, Williams AL, Mortin-Toth S, Nicotra ML, Rothstein DM, Shlomchik WD, Matozaki T, Isenberg JS, Oberbarnscheidt MH, Danska JS, Lakkis FG. Donor SIRPa polymorphism modulates the innate immune response to allogeneic grafts. Sci Immunol. 2017 Jun 23; 2(12). PMID: 28783664.
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    4. Chen J, Zhong MC, Guo H, Davidson D, Mishel S, Lu Y, Rhee I, Pérez-Quintero LA, Zhang S, Cruz-Munoz ME, Wu N, Vinh DC, Sinha M, Calderon V, Lowell CA, Danska JS, Veillette A. SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin. Nature. 2017 04 27; 544(7651):493-497. PMID: 28424516.
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    5. Paun A, Yau C, Danska JS. The Influence of the Microbiome on Type 1 Diabetes. J Immunol. 2017 01 15; 198(2):590-595. PMID: 28069754.
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    6. Israelian N, Danska JS. Sex Effects at the Ramparts: Nutrient- and Microbe-Mediated Regulation of the Immune-Metabolic Interface. Adv Exp Med Biol. 2017; 1043:113-140. PMID: 29224093.
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    7. Paun A, Danska JS. Modulation of type 1 and type 2 diabetes risk by the intestinal microbiome. Pediatr Diabetes. 2016 11; 17(7):469-477. PMID: 27484959.
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    8. Paun A, Yau C, Danska JS. Immune recognition and response to the intestinal microbiome in type 1 diabetes. J Autoimmun. 2016 07; 71:10-8. PMID: 26908163.
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    9. Jiang Y, Xiong X, Danska J, Parkinson J. Metatranscriptomic analysis of diverse microbial communities reveals core metabolic pathways and microbiome-specific functionality. Microbiome. 2016 Jan 12; 4:2. PMID: 26757703.
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    10. Paun A, Danska JS. Immuno-ecology: how the microbiome regulates tolerance and autoimmunity. Curr Opin Immunol. 2015 Dec; 37:34-9. PMID: 26460968.
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    11. Semenkovich CF, Danska J, Darsow T, Dunne JL, Huttenhower C, Insel RA, McElvaine AT, Ratner RE, Shuldiner AR, Blaser MJ. American Diabetes Association and JDRF Research Symposium: Diabetes and the Microbiome. Diabetes. 2015 Dec; 64(12):3967-77. PMID: 26420863.
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    12. Motta VN, Markle JG, Gulban O, Mortin-Toth S, Liao KC, Mogridge J, Steward CA, Danska JS. Identification of the inflammasome Nlrp1b as the candidate gene conferring diabetes risk at the Idd4.1 locus in the nonobese diabetic mouse. J Immunol. 2015 Jun 15; 194(12):5663-73. PMID: 25964492.
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    13. Klein SL, Schiebinger L, Stefanick ML, Cahill L, Danska J, de Vries GJ, Kibbe MR, McCarthy MM, Mogil JS, Woodruff TK, Zucker I. Opinion: Sex inclusion in basic research drives discovery. Proc Natl Acad Sci U S A. 2015 Apr 28; 112(17):5257-8. PMID: 25902532.
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    14. Celaj A, Markle J, Danska J, Parkinson J. Comparison of assembly algorithms for improving rate of metatranscriptomic functional annotation. Microbiome. 2014; 2:39. PMID: 25411636.
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    15. Danska JS. Sex matters for mechanism. Sci Transl Med. 2014 Oct 15; 6(258):258fs40. PMID: 25320230.
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    16. Wong AS, Mortin-Toth S, Sung M, Canty AJ, Gulban O, Greaves DR, Danska JS. Polymorphism in the innate immune receptor SIRPa controls CD47 binding and autoimmunity in the nonobese diabetic mouse. J Immunol. 2014 Nov 15; 193(10):4833-44. PMID: 25305319.
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    17. Gedye CA, Hussain A, Paterson J, Smrke A, Saini H, Sirskyj D, Pereira K, Lobo N, Stewart J, Go C, Ho J, Medrano M, Hyatt E, Yuan J, Lauriault S, Meyer M, Kondratyev M, van den Beucken T, Jewett M, Dirks P, Guidos CJ, Danska J, Wang J, Wouters B, Neel B, Rottapel R, Ailles LE. Cell surface profiling using high-throughput flow cytometry: a platform for biomarker discovery and analysis of cellular heterogeneity. PLoS One. 2014; 9(8):e105602. PMID: 25170899.
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    18. Markle JG, Frank DN, Adeli K, von Bergen M, Danska JS. Microbiome manipulation modifies sex-specific risk for autoimmunity. Gut Microbes. 2014 Jul 01; 5(4):485-93. PMID: 25007153.
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    19. Dunne JL, Triplett EW, Gevers D, Xavier R, Insel R, Danska J, Atkinson MA. The intestinal microbiome in type 1 diabetes. Clin Exp Immunol. 2014 Jul; 177(1):30-7. PMID: 24628412.
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    20. Johnson RM, Papp E, Grandal I, Kowalski PE, Nutter L, Wong RC, Joseph-George AM, Danska JS, Guidos CJ. MuLV-related endogenous retroviral elements and Flt3 participate in aberrant end-joining events that promote B-cell leukemogenesis. Genes Dev. 2014 Jun 01; 28(11):1179-90. PMID: 24888589.
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    21. Perova T, Grandal I, Nutter LM, Papp E, Matei IR, Beyene J, Kowalski PE, Hitzler JK, Minden MD, Guidos CJ, Danska JS. Therapeutic potential of spleen tyrosine kinase inhibition for treating high-risk precursor B cell acute lymphoblastic leukemia. Sci Transl Med. 2014 May 14; 6(236):236ra62. PMID: 24828076.
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    22. Nuvolone M, Kana V, Hutter G, Sakata D, Mortin-Toth SM, Russo G, Danska JS, Aguzzi A. SIRPa polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells. J Exp Med. 2013 Nov 18; 210(12):2539-52. PMID: 24145514.
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    23. Markle JG, Mortin-Toth S, Wong AS, Geng L, Hayday A, Danska JS. ?d T cells are essential effectors of type 1 diabetes in the nonobese diabetic mouse model. J Immunol. 2013 Jun 01; 190(11):5392-401. PMID: 23626013.
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    24. Ho JM, Danska JS, Wang JC. Targeting SIRPa in cancer. Oncoimmunology. 2013 Feb 01; 2(2):e23081. PMID: 23525504.
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    25. Markle JG, Frank DN, Mortin-Toth S, Robertson CE, Feazel LM, Rolle-Kampczyk U, von Bergen M, McCoy KD, Macpherson AJ, Danska JS. Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science. 2013 Mar 01; 339(6123):1084-8. PMID: 23328391.
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    26. Theocharides AP, Jin L, Cheng PY, Prasolava TK, Malko AV, Ho JM, Poeppl AG, van Rooijen N, Minden MD, Danska JS, Dick JE, Wang JC. Disruption of SIRPa signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts. J Exp Med. 2012 Sep 24; 209(10):1883-99. PMID: 22945919.
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    27. Xiong X, Frank DN, Robertson CE, Hung SS, Markle J, Canty AJ, McCoy KD, Macpherson AJ, Poussier P, Danska JS, Parkinson J. Generation and analysis of a mouse intestinal metatranscriptome through Illumina based RNA-sequencing. PLoS One. 2012; 7(4):e36009. PMID: 22558305.
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    28. Eppert K, Takenaka K, Lechman ER, Waldron L, Nilsson B, van Galen P, Metzeler KH, Poeppl A, Ling V, Beyene J, Canty AJ, Danska JS, Bohlander SK, Buske C, Minden MD, Golub TR, Jurisica I, Ebert BL, Dick JE. Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med. 2011 Aug 28; 17(9):1086-93. PMID: 21873988.
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    29. Yuan JS, Tan JB, Visan I, Matei IR, Urbanellis P, Xu K, Danska JS, Egan SE, Guidos CJ. Lunatic Fringe prolongs Delta/Notch-induced self-renewal of committed aß T-cell progenitors. Blood. 2011 Jan 27; 117(4):1184-95. PMID: 21097675.
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    30. Lundholm M, Mayans S, Motta V, Löfgren-Burström A, Danska J, Holmberg D. Variation in the Cd3 zeta (Cd247) gene correlates with altered T cell activation and is associated with autoimmune diabetes. J Immunol. 2010 May 15; 184(10):5537-44. PMID: 20400699.
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    31. Hadjiyanni I, Siminovitch KA, Danska JS, Drucker DJ. Glucagon-like peptide-1 receptor signalling selectively regulates murine lymphocyte proliferation and maintenance of peripheral regulatory T cells. Diabetologia. 2010 Apr; 53(4):730-40. PMID: 20225396.
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    32. Danska JS, Poussier P. After the GWAS rush: nuggets of insight into the pathogenesis of autoimmune disease. Semin Immunol. 2009 Dec; 21(6):313-7. PMID: 19926302.
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    33. Steward CA, Humphray S, Plumb B, Jones MC, Quail MA, Rice S, Cox T, Davies R, Bonfield J, Keane TM, Nefedov M, de Jong PJ, Lyons P, Wicker L, Todd J, Hayashizaki Y, Gulban O, Danska J, Harrow J, Hubbard T, Rogers J, Adams DJ. Genome-wide end-sequenced BAC resources for the NOD/MrkTac() and NOD/ShiLtJ() mouse genomes. Genomics. 2010 Feb; 95(2):105-10. PMID: 19909804.
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    34. Xu K, Nieuwenhuis E, Cohen BL, Wang W, Canty AJ, Danska JS, Coultas L, Rossant J, Wu MY, Piscione TD, Nagy A, Gossler A, Hicks GG, Hui CC, Henkelman RM, Yu LX, Sled JG, Gridley T, Egan SE. Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis. Am J Physiol Lung Cell Mol Physiol. 2010 Jan; 298(1):L45-56. PMID: 19897741.
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    35. Takenaka K, Prasolava TK, Wang JC, Mortin-Toth SM, Khalouei S, Gan OI, Dick JE, Danska JS. Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells. Nat Immunol. 2007 Dec; 8(12):1313-23. PMID: 17982459.
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    36. Curry JD, Schulz D, Guidos CJ, Danska JS, Nutter L, Nussenzweig A, Schlissel MS. Chromosomal reinsertion of broken RSS ends during T cell development. J Exp Med. 2007 Oct 01; 204(10):2293-303. PMID: 17785508.
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    37. Ivakine EA, Mortin-Toth SM, Gulban OM, Valova A, Canty A, Scott C, Danska JS. The idd4 locus displays sex-specific epistatic effects on type 1 diabetes susceptibility in nonobese diabetic mice. Diabetes. 2006 Dec; 55(12):3611-9. PMID: 17130511.
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    38. Matei IR, Gladdy RA, Nutter LM, Canty A, Guidos CJ, Danska JS. ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes. Blood. 2007 Mar 01; 109(5):1887-96. PMID: 17077325.
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    39. Gladdy RA, Nutter LM, Kunath T, Danska JS, Guidos CJ. p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc. Mol Cancer Res. 2006 May; 4(5):311-8. PMID: 16687486.
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    40. Ivakine EA, Gulban OM, Mortin-Toth SM, Wankiewicz E, Scott C, Spurrell D, Canty A, Danska JS. Molecular genetic analysis of the Idd4 locus implicates the IFN response in type 1 diabetes susceptibility in nonobese diabetic mice. J Immunol. 2006 Mar 01; 176(5):2976-90. PMID: 16493056.
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    41. Matei IR, Guidos CJ, Danska JS. ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection. Immunol Rev. 2006 Feb; 209:142-58. PMID: 16448540.
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    42. Ivakine EA, Fox CJ, Paterson AD, Mortin-Toth SM, Canty A, Walton DS, Aleksa K, Ito S, Danska JS. Sex-specific effect of insulin-dependent diabetes 4 on regulation of diabetes pathogenesis in the nonobese diabetic mouse. J Immunol. 2005 Jun 01; 174(11):7129-40. PMID: 15905556.
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    43. Gladdy RA, Taylor MD, Williams CJ, Grandal I, Karaskova J, Squire JA, Rutka JT, Guidos CJ, Danska JS. The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice. Cancer Cell. 2003 Jan; 3(1):37-50. PMID: 12559174.
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    44. Bray PW, Neligan PC, Bowen CV, Danska JS, Boyer MI. Development and validation of new model for microvascular transplantation of epiphyseal plate allografts with minimal adjoining epiphyseal and metaphyseal bone. Microsurgery. 2003; 23(2):153-63. PMID: 12740889.
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    45. Chiu PP, Ivakine E, Mortin-Toth S, Danska JS. Susceptibility to lymphoid neoplasia in immunodeficient strains of nonobese diabetic mice. Cancer Res. 2002 Oct 15; 62(20):5828-34. PMID: 12384545.
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    46. Chiu PP, Jevnikar AM, Danska JS. Genetic control of T and B lymphocyte activation in nonobese diabetic mice. J Immunol. 2001 Dec 15; 167(12):7169-79. PMID: 11739540.
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    47. Fox CJ, Danska JS. Molecular analysis of mouse T cell receptor expression using PCR. Curr Protoc Immunol. 2001 May; Chapter 10:Unit 10.27. PMID: 18432692.
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    48. Chiu PP, Serreze DV, Danska JS. Development and function of diabetogenic T-cells in B-cell-deficient nonobese diabetic mice. Diabetes. 2001 Apr; 50(4):763-70. PMID: 11289040.
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    49. Williams CJ, Grandal I, Vesprini DJ, Wojtyra U, Danska JS, Guidos CJ. Irradiation promotes V(D)J joining and RAG-dependent neoplastic transformation in SCID T-cell precursors. Mol Cell Biol. 2001 Jan; 21(2):400-13. PMID: 11134329.
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    50. Fox CJ, Paterson AD, Mortin-Toth SM, Danska JS. Two genetic loci regulate T cell-dependent islet inflammation and drive autoimmune diabetes pathogenesis. Am J Hum Genet. 2000 Jul; 67(1):67-81. PMID: 10848492.
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    51. Fox CJ, Danska JS. Independent genetic regulation of T-cell and antigen-presenting cell participation in autoimmune islet inflammation. Diabetes. 1998 Mar; 47(3):331-8. PMID: 9519736.
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    52. Lista F, Bertness V, Guidos CJ, Danska JS, Kirsch IR. The absolute number of trans-rearrangements between the TCRG and TCRB loci is predictive of lymphoma risk: a severe combined immune deficiency (SCID) murine model. Cancer Res. 1997 Oct 01; 57(19):4408-13. PMID: 9331104.
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    53. Pearson CI, Smilek DE, Danska JS, McDevitt HO. Induction of a heterogeneous TCR repertoire in (PL/JXSJL/J)F1 mice by myelin basic protein peptide Ac1-11 and its analog Ac1-11[4A]. Mol Immunol. 1997 Aug; 34(11):781-92. PMID: 9444977.
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    54. Danska JS, Guidos CJ. Essential and perilous: V(D)J recombination and DNA damage checkpoints in lymphocyte precursors. Semin Immunol. 1997 Jun; 9(3):199-206. PMID: 9200331.
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    55. Fox CJ, Danska JS. IL-4 expression at the onset of islet inflammation predicts nondestructive insulitis in nonobese diabetic mice. J Immunol. 1997 Mar 01; 158(5):2414-24. PMID: 9036992.
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    56. Danska JS, Holland DP, Mariathasan S, Williams KM, Guidos CJ. Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes. Mol Cell Biol. 1996 Oct; 16(10):5507-17. PMID: 8816463.
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    57. Guidos CJ, Williams CJ, Grandal I, Knowles G, Huang MT, Danska JS. V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. Genes Dev. 1996 Aug 15; 10(16):2038-54. PMID: 8769647.
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    58. Livák F, Welsh SC, Guidos CJ, Crispe IN, Danska JS, Schatz DG. Transient restoration of gene rearrangement at multiple T cell receptor loci in gamma-irradiated scid mice. J Exp Med. 1996 Aug 01; 184(2):419-28. PMID: 8760795.
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    59. Wu G, Danska JS, Guidos CJ. Lck dependence of signaling pathways activated by gamma-irradiation and CD3 epsilon engagement in RAG-1(-/-)-immature thymocytes. Int Immunol. 1996 Jul; 8(7):1159-64. PMID: 8757961.
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    60. Boyer MI, Danska JS, Nolan L, Kiral A, Bowen CV. Microvascular transplantation of physeal allografts. J Bone Joint Surg Br. 1995 Sep; 77(5):806-14. PMID: 7559716.
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    61. Tang XX, Ikegaki N, Danska JS, Heber-Katz E. An alternative view of T-cell receptor-MHC interaction: T-cell receptor binds transversally to the alpha-helices of the MHC molecule. Mol Immunol. 1995 Jun; 32(9):661-8. PMID: 7643858.
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    62. Boyer MI, Bowen CV, Danska JS. Restriction fragment-length polymorphism analysis of the major histocompatibility complex in New Zealand white rabbits. Transplantation. 1995 Apr 15; 59(7):1043-6. PMID: 7709441.
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    63. Galley KA, Danska JS. Peri-islet infiltrates of young non-obese diabetic mice display restricted TCR beta-chain diversity. J Immunol. 1995 Mar 15; 154(6):2969-82. PMID: 7533189.
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    64. Guidos CJ, Williams CJ, Wu GE, Paige CJ, Danska JS. Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor beta chain-independent pathway. J Exp Med. 1995 Mar 01; 181(3):1187-95. PMID: 7869035.
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    65. Danska JS, Pflumio F, Williams CJ, Huner O, Dick JE, Guidos CJ. Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agents. Science. 1994 Oct 21; 266(5184):450-5. PMID: 7524150.
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    66. Rapoport MJ, Jaramillo A, Zipris D, Lazarus AH, Serreze DV, Leiter EH, Cyopick P, Danska JS, Delovitch TL. Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J Exp Med. 1993 Jul 01; 178(1):87-99. PMID: 8315397.
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    67. Sellins KS, Danska JS, Paragas V, Fathman CG. Limited T cell receptor beta-chain usage in the sperm whale myoglobin 110-121/E alpha dA beta d response by H-2d congenic mouse strains. J Immunol. 1992 Oct 01; 149(7):2323-7. PMID: 1382096.
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    68. Ruberti G, Livingstone A, Danska JS, Gaur A, Fathman CG. Analysis of the ternary complex of antigen, MHC and T-cell receptor: the influence of the T-cell receptor V beta repertoire on the V beta gene element usage. Res Immunol. 1991 Jun-Aug; 142(5-6):491-3. PMID: 1721721.
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    69. Guidos CJ, Danska JS, Fathman CG, Weissman IL. T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages. J Exp Med. 1990 Sep 01; 172(3):835-45. PMID: 2143774.
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    70. Danska JS, Livingstone AM, Paragas V, Ishihara T, Fathman CG. The presumptive CDR3 regions of both T cell receptor alpha and beta chains determine T cell specificity for myoglobin peptides. J Exp Med. 1990 Jul 01; 172(1):27-33. PMID: 1694219.
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    71. Danska JS, McIntyre BW, McDevitt HO, Weissman IL. Structural similarity between a primitive chordate membrane heterodimer and lymphocyte antigen receptors. Int Immunol. 1990; 2(9):795-802. PMID: 2278999.
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    72. Danska JS. The T cell receptor: structure, molecular diversity and somatic localization. Curr Opin Immunol. 1989 Oct; 2(1):81-6. PMID: 2532915.
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    73. Silver LM, Uman J, Danska J, Garrels JI. A diversified set of testicular cell proteins specified by genes within the mouse t complex. Cell. 1983 Nov; 35(1):35-45. PMID: 6684996.
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