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Shinya Ito

TitleDivision Head
InstitutionThe Hospital for Sick Children
DepartmentClinical Pharmacology and Toxicology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wada-Shimosato Y, Tanoshima R, Hiratoko K, Takeuchi M, Tsujimoto SI, Shiba N, Ito S, Yamanaka T, Ito S. Effectiveness of acyclovir prophylaxis against varicella zoster virus disease after allogeneic hematopoietic cell transplantation: A systematic review and meta-analysis. Transpl Infect Dis. 2019 Feb 13; e13061. PMID: 30756465.
      View in: PubMed
    2. Verstegen RHJ, Ito S. Drugs in lactation. J Obstet Gynaecol Res. 2019 Mar; 45(3):522-531. PMID: 30663176.
      View in: PubMed
    3. Asztalos EV, Kiss A, daSilva OP, Campbell-Yeo M, Ito S, Knoppert D. Evaluating the Effect of a 14-Day Course of Domperidone on Breast Milk Production: A Per-Protocol Analysis from the EMPOWER Trial. Breastfeed Med. 2019 Mar; 14(2):102-107. PMID: 30543461.
      View in: PubMed
    4. Wong H, Moss C, Moss SM, Shah V, Halperin SA, Ito S, Mithal P, Qu A, Taddio A. Effect of alcohol skin cleansing on vaccination-associated infections and local skin reactions: a randomized controlled trial. Hum Vaccin Immunother. 2018 Dec 04. PMID: 30513266.
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    5. Delaney SR, Malik PRV, Stefan C, Edginton AN, Colantonio DA, Ito S. Predicting Escitalopram Exposure to Breastfeeding Infants: Integrating Analytical and In Silico Techniques. Clin Pharmacokinet. 2018 Dec; 57(12):1603-1611. PMID: 29651785.
      View in: PubMed
    6. Asztalos EV, Kiss A, da Silva OP, Campbell-Yeo M, Ito S, Knoppert D. Pregnancy gestation at delivery and breast milk production: a secondary analysis from the EMPOWER trial. Matern Health Neonatol Perinatol. 2018; 4:21. PMID: 30410781.
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    7. Ito S. Treating a Child With Mental Illness. Clin Pharmacol Ther. 2018 Oct; 104(4):592-594. PMID: 30222188.
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    8. Ito S. Opioids in Breast Milk: Pharmacokinetic Principles and Clinical Implications. J Clin Pharmacol. 2018 Oct; 58 Suppl 10:S151-S163. PMID: 30248201.
      View in: PubMed
    9. Aoki H, Ito N, Kaniwa N, Saito Y, Wada Y, Nakajima K, Sago H, Murashima A, Okamoto A, Ito S. Low Levels of Amlodipine in Breast Milk and Plasma. Breastfeed Med. 2018 11; 13(9):622-626. PMID: 30265578.
      View in: PubMed
    10. Yazdani-Brojeni P, Tanoshima R, Taguchi N, Garcia-Bournissen F, Wallach I, Moretti ME, Verjee Z, Ito S. Quetiapine Excretion Into Human Breast Milk. J Clin Psychopharmacol. 2018 Aug; 38(4):362-364. PMID: 29912789.
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    11. Spencer Noakes TL, Przybycien TS, Forwell A, Nicholls C, Zhou YQ, Butcher DT, Weksberg R, Guger SL, Spiegler BJ, Schachar RJ, Hitzler J, Ito S, van der Plas E, Nieman BJ. Brain Development and Heart Function after Systemic Single-Agent Chemotherapy in a Mouse Model of Childhood Leukemia Treatment. Clin Cancer Res. 2018 Dec 01; 24(23):6040-6052. PMID: 30054283.
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    12. Yu AM, Ito S, Leibson T, Lavi S, Fu LW, Weinstein M, Skotnicki SM. Pediatric Wells syndrome (eosinophilic cellulitis) after vaccination: A case report and review of the literature. Pediatr Dermatol. 2018 Sep; 35(5):e262-e264. PMID: 29998475.
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    13. Iorio A, Edginton AN, Blanchette V, Blatny J, Boban A, Cnossen M, Collins P, Croteau SE, Fischer K, Hart DP, Ito S, Korth-Bradley J, Lethagen S, Lillicrap D, Makris M, Mathôt R, Morfini M, Neufeld EJ, Spears J. Performing and interpreting individual pharmacokinetic profiles in patients with Hemophilia A or B: Rationale and general considerations. Res Pract Thromb Haemost. 2018 Jul; 2(3):535-548. PMID: 30046759.
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    14. Latuskie KA, Andrews NCZ, Motz M, Leibson T, Austin Z, Ito S, Pepler DJ. Reasons for substance use continuation and discontinuation during pregnancy: A qualitative study. Women Birth. 2019 Feb; 32(1):e57-e64. PMID: 29673617.
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    15. Cohn I, Cohn RD, Ito S. Professional opportunity for pharmacists to integrate pharmacogenomics in medication therapy. Can Pharm J (Ott). 2018 May-Jun; 151(3):167-169. PMID: 29796128.
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    16. De Bruyne P, Ito S. Toxicity of long-term use of proton pump inhibitors in children. Arch Dis Child. 2018 01; 103(1):78-82. PMID: 29237614.
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    17. Hayeems RZ, Bhawra J, Tsiplova K, Meyn MS, Monfared N, Bowdin S, Stavropoulos DJ, Marshall CR, Basran R, Shuman C, Ito S, Cohn I, Hum C, Girdea M, Brudno M, Cohn RD, Scherer SW, Ungar WJ. Care and cost consequences of pediatric whole genome sequencing compared to chromosome microarray. Eur J Hum Genet. 2017 12; 25(12):1303-1312. PMID: 29158552.
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    18. Van Der Plas E, Erdman L, Nieman BJ, Weksberg R, Butcher DT, O'connor DL, Aufreiter S, Hitzler J, Guger SL, Schachar RJ, Ito S, Spiegler BJ. Characterizing neurocognitive late effects in childhood leukemia survivors using a combination of neuropsychological and cognitive neuroscience measures. Child Neuropsychol. 2018 Nov; 24(8):999-1014. PMID: 29017430.
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    19. Moretti ME, Lato DF, Berger H, Koren G, Ito S, Ungar WJ. A cost-effectiveness analysis of maternal CYP2D6 genetic testing to guide treatment for postpartum pain and avert infant adverse events. Pharmacogenomics J. 2018 05 22; 18(3):391-397. PMID: 28696420.
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    20. Ito S. Drugs for Children. Clin Pharmacol Ther. 2017 Jun; 101(6):704-706. PMID: 28510298.
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    21. Cohn I, Paton TA, Marshall CR, Basran R, Stavropoulos DJ, Ray PN, Monfared N, Hayeems RZ, Meyn MS, Bowdin S, Scherer SW, Cohn RD, Ito S. Genome sequencing as a platform for pharmacogenetic genotyping: a pediatric cohort study. NPJ Genom Med. 2017; 2:19. PMID: 29263831.
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    22. Madjunkov M, Chaudhry S, Ito S. Listeriosis during pregnancy. Arch Gynecol Obstet. 2017 Aug; 296(2):143-152. PMID: 28536811.
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    23. Ito S, Goto A, Ishii K, Ota M, Yasumura S, Fujimori K. Fukushima Mothers' Concerns and Associated Factors After the Fukushima Nuclear Power Plant Disaster. Asia Pac J Public Health. 2017 Mar; 29(2_suppl):151S-160S. PMID: 28330402.
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    24. Asztalos EV, Campbell-Yeo M, da Silva OP, Ito S, Kiss A, Knoppert D. Enhancing Human Milk Production With Domperidone in Mothers of Preterm Infants. J Hum Lact. 2017 02; 33(1):181-187. PMID: 28107101.
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    25. van der Plas E, Schachar RJ, Hitzler J, Crosbie J, Guger SL, Spiegler BJ, Ito S, Nieman BJ. Brain structure, working memory and response inhibition in childhood leukemia survivors. Brain Behav. 2017 02; 7(2):e00621. PMID: 28239531.
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    26. Kobayashi T, Matsuyama T, Takeuchi M, Ito S. Reprod Toxicol. 2017 01; 67:148. PMID: 27915013.
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    27. Pariente G, Leibson T, Carls A, Adams-Webber T, Ito S, Koren G. Pregnancy-Associated Changes in Pharmacokinetics: A Systematic Review. PLoS Med. 2016 Nov; 13(11):e1002160. PMID: 27802281.
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    28. Takeuchi M, Tanoshima R, Miyagawa N, Sarashina T, Kato H, Kajiwara R, Ito S, Goto H. Population pharmacokinetics of thrombomodulin alfa in pediatric patients with hematological malignancy and disseminated intravascular coagulation. Pediatr Blood Cancer. 2017 03; 64(3). PMID: 27734584.
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    29. Ishikawa Y, Ito S, Nagata K, Sakai LY, Bächinger HP. Intracellular mechanisms of molecular recognition and sorting for transport of large extracellular matrix molecules. Proc Natl Acad Sci U S A. 2016 10 11; 113(41):E6036-E6044. PMID: 27679847.
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    30. Kobayashi T, Matsuyama T, Takeuchi M, Ito S. Autism spectrum disorder and prenatal exposure to selective serotonin reuptake inhibitors: A systematic review and meta-analysis. Reprod Toxicol. 2016 10; 65:170-178. PMID: 27474253.
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    31. Ito S. Mother and Child: Medication Use in Pregnancy and Lactation. Clin Pharmacol Ther. 2016 07; 100(1):8-11. PMID: 27272612.
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    32. Takeuchi M, Kobayashi T, Brandão LR, Ito S. Effect of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin maintenance dose in children aged less than 18 years: a protocol for systematic review and meta-analysis. Syst Rev. 2016 06 23; 5(1):105. PMID: 27334984.
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    33. Bapat P, Pinto LS, Lubetsky A, Aleksa K, Berger H, Koren G, Ito S. Examining the transplacental passage of apixaban using the dually perfused human placenta. J Thromb Haemost. 2016 07; 14(7):1436-41. PMID: 27149680.
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    34. Zur RM, Roy LM, Ito S, Beyene J, Carew C, Ungar WJ. Thiopurine S-methyltransferase testing for averting drug toxicity: a meta-analysis of diagnostic test accuracy. Pharmacogenomics J. 2016 08; 16(4):305-11. PMID: 27217052; PMCID: PMC4957983.
    35. Roy LM, Zur RM, Uleryk E, Carew C, Ito S, Ungar WJ. Thiopurine S-methyltransferase testing for averting drug toxicity in patients receiving thiopurines: a systematic review. Pharmacogenomics. 2016 04; 17(6):633-56. PMID: 27020704; PMCID: PMC4931919.
    36. Wu AM, Dedina L, Dalvi P, Yang M, Leon-Cheon J, Earl B, Harper PA, Ito S. Riboflavin uptake transporter Slc52a2 (RFVT2) is upregulated in the mouse mammary gland during lactation. Am J Physiol Regul Integr Comp Physiol. 2016 Apr 01; 310(7):R578-85. PMID: 26791833.
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    37. Kaplan YC, Koren G, Ito S, Bozzo P. Fluconazole use during breastfeeding. Can Fam Physician. 2015 Oct; 61(10):875-6. PMID: 26759844; PMCID: PMC4607332.
    38. Ito S. Children: Are We Doing Enough? Clin Pharmacol Ther. 2015 Sep; 98(3):222-4. PMID: 26072702.
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    39. Tanoshima M, Kobayashi T, Tanoshima R, Beyene J, Koren G, Ito S. Risks of congenital malformations in offspring exposed to valproic acid in utero: A systematic review and cumulative meta-analysis. Clin Pharmacol Ther. 2015 Oct; 98(4):417-41. PMID: 26044279.
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    40. Shaw K, Amstutz U, Kim RB, Lesko LJ, Turgeon J, Michaud V, Hwang S, Ito S, Ross C, Carleton BC. Clinical Practice Recommendations on Genetic Testing of CYP2C9 and VKORC1 Variants in Warfarin Therapy. Ther Drug Monit. 2015 Aug; 37(4):428-36. PMID: 26186657.
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    41. van der Plas E, Nieman BJ, Butcher DT, Hitzler JK, Weksberg R, Ito S, Schachar R. Neurocognitive Late Effects of Chemotherapy in Survivors of Acute Lymphoblastic Leukemia: Focus on Methotrexate. J Can Acad Child Adolesc Psychiatry. 2015; 24(1):25-32. PMID: 26336377; PMCID: PMC4357331.
    42. Kawasaki K, Ushioda R, Ito S, Ikeda K, Masago Y, Nagata K. Deletion of the collagen-specific molecular chaperone Hsp47 causes endoplasmic reticulum stress-mediated apoptosis of hepatic stellate cells. J Biol Chem. 2015 Feb 06; 290(6):3639-46. PMID: 25525267; PMCID: PMC4319029.
    43. Ito S. Chronic illness and the breastfeeding mother. J Popul Ther Clin Pharmacol. 2014; 21(3):e565-8. PMID: 25527795.
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    44. Thorne JC, Nadarajah T, Moretti M, Ito S. Methotrexate use in a breastfeeding patient with rheumatoid arthritis. J Rheumatol. 2014 Nov; 41(11):2332. PMID: 25362724.
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    45. Tanoshima R, Bournissen FG, Tanigawara Y, Kristensen JH, Taddio A, Ilett KF, Begg EJ, Wallach I, Ito S. Population PK modelling and simulation based on fluoxetine and norfluoxetine concentrations in milk: a milk concentration-based prediction model. Br J Clin Pharmacol. 2014 Oct; 78(4):918-28. PMID: 24773313; PMCID: PMC4239985.
    46. Ito S. Biotransformation. Clin Pharmacol Ther. 2014 Sep; 96(3):281-3. PMID: 25141949.
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    47. Neuman G, Boodhan S, Wurman I, Koren G, Bitnun A, Kirby-Allen M, Ito S. Ceftriaxone-induced immune hemolytic anemia. Ann Pharmacother. 2014 Dec; 48(12):1594-604. PMID: 25163809.
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    48. Burnett HF, Tanoshima R, Chandranipapongse W, Madadi P, Ito S, Ungar WJ. Testing for thiopurine methyltransferase status for safe and effective thiopurine administration: a systematic review of clinical guidance documents. Pharmacogenomics J. 2014 Dec; 14(6):493-502. PMID: 25156214.
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    49. Wu AM, Yang M, Dalvi P, Turinsky AL, Wang W, Butcher D, Egan SE, Weksberg R, Harper PA, Ito S. Role of STAT5 and epigenetics in lactation-associated upregulation of multidrug transporter ABCG2 in the mammary gland. Am J Physiol Endocrinol Metab. 2014 Oct 01; 307(7):E596-610. PMID: 25117410.
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    50. Neuman G, Colantonio D, Delaney S, Szynkaruk M, Ito S. Bupropion and Escitalopram During Lactation. Ann Pharmacother. 2014 Jul; 48(7):928-931. PMID: 24732787.
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    51. Amstutz U, Shear NH, Rieder MJ, Hwang S, Fung V, Nakamura H, Connolly MB, Ito S, Carleton BC. Recommendations for HLA-B*15:02 and HLA-A*31:01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions. Epilepsia. 2014 Apr; 55(4):496-506. PMID: 24597466.
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    52. Yazdani-Brojeni P, Garcia-Bournissen F, Fujii H, Tanoshima R, Ito S. Relative bioequivalence of amoxicillin dissolved in breast milk. Arch Dis Child. 2014 Mar; 99(3):258-61. PMID: 24363363.
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    53. Madadi P, Amstutz U, Rieder M, Ito S, Fung V, Hwang S, Turgeon J, Michaud V, Koren G, Carleton BC. Clinical practice guideline: CYP2D6 genotyping for safe and efficacious codeine therapy. J Popul Ther Clin Pharmacol. 2013; 20(3):e369-96. PMID: 24214521.
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    54. Science M, Ito S, Kitai I. Isoniazid toxicity in a 5-year-old boy. CMAJ. 2013 Jul 09; 185(10):894-6. PMID: 23670154; PMCID: PMC3707995.
    55. Shaw K, Amstutz U, Castro-Pastrana L, Loo TT, Ross CJ, Ito S, Reider MJ, Maher M, Macleod S, Koren G, Hayden MR, Carleton BC. Pharmacogenomic investigation of adverse drug reactions(ADRs): the ADR prioritization tool, APT. J Popul Ther Clin Pharmacol. 2013; 20(2):e110-27. PMID: 23824325.
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    56. Wu AM, Dalvi P, Lu X, Yang M, Riddick DS, Matthews J, Clevenger CV, Ross DD, Harper PA, Ito S. Induction of multidrug resistance transporter ABCG2 by prolactin in human breast cancer cells. Mol Pharmacol. 2013 Feb; 83(2):377-88. PMID: 23150485.
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    57. Cressman AM, Koren G, Pupco A, Kim E, Ito S, Bozzo P. Maternal cocaine use during breastfeeding. Can Fam Physician. 2012 Nov; 58(11):1218-9. PMID: 23152457; PMCID: PMC3498013.
    58. Bozzo P, Koren G, Ito S. Health Canada advisory on domperidone should I avoid prescribing domperidone to women to increase milk production [corrected]? Can Fam Physician. 2012 Sep; 58(9):952-3. PMID: 22972723; PMCID: PMC3440266.
    59. Asztalos EV, Campbell-Yeo M, daSilva OP, Kiss A, Knoppert DC, Ito S. Enhancing breast milk production with Domperidone in mothers of preterm neonates (EMPOWER trial). BMC Pregnancy Childbirth. 2012 Aug 31; 12:87. PMID: 22935052; PMCID: PMC3532128.
    60. Perrin AJ, Gunda M, Yu B, Yen K, Ito S, Forster S, Tissenbaum HA, Derry WB. Noncanonical control of C. elegans germline apoptosis by the insulin/IGF-1 and Ras/MAPK signaling pathways. Cell Death Differ. 2013 Jan; 20(1):97-107. PMID: 22935616; PMCID: PMC3524627.
    61. Ito S, Nakamura H, Kobayashi T. Pediatric pharmacology in Japan. Paediatr Drugs. 2012 Aug 01; 14(4):247-9. PMID: 22515698.
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    62. Koren G, Nulman I, Aleksa K, Gareri J, Einarson A, Ito S. Essay for the 2011 CIHR/CMAJ award: Motherisk--caring for mothers, protecting the unborn. CMAJ. 2012 Feb 07; 184(2):E155-7. PMID: 22271922; PMCID: PMC3273537.
    63. Macleod S, Ito S. Walking the tightrope. Paediatr Child Health. 2011 Nov; 16(9):527. PMID: 23115486; PMCID: PMC3223882.
    64. Ito S. Pharmacokinetics 101. Paediatr Child Health. 2011 Nov; 16(9):535-6. PMID: 23115489; PMCID: PMC3223885.
    65. Finkelstein Y, Soon GS, Acuna P, George M, Pope E, Ito S, Shear NH, Koren G, Shannon MW, Garcia-Bournissen F. Recurrence and outcomes of Stevens-Johnson syndrome and toxic epidermal necrolysis in children. Pediatrics. 2011 Oct; 128(4):723-8. PMID: 21890829.
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    66. Panchaud A, Garcia-Bournissen F, Csajka C, Kristensen JH, Taddio A, Ilett KF, Begg EJ, Ito S. Prediction of infant drug exposure through breastfeeding: population PK modeling and simulation of fluoxetine exposure. Clin Pharmacol Ther. 2011 Jun; 89(6):830-6. PMID: 21525869.
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    67. Ceelie I, James LP, Gijsen V, Mathot RA, Ito S, Tesselaar CD, Tibboel D, Koren G, de Wildt SN. Acute liver failure after recommended doses of acetaminophen in patients with myopathies. Crit Care Med. 2011 Apr; 39(4):678-82. PMID: 21242792; PMCID: PMC3209512.
    68. Blankier S, McCrindle BW, Ito S, Yeung RS. The role of atorvastatin in regulating the immune response leading to vascular damage in a model of Kawasaki disease. Clin Exp Immunol. 2011 May; 164(2):193-201. PMID: 21361911; PMCID: PMC3087911.
    69. Tan KP, Wood GA, Yang M, Ito S. Participation of nuclear factor (erythroid 2-related), factor 2 in ameliorating lithocholic acid-induced cholestatic liver injury in mice. Br J Pharmacol. 2010 Nov; 161(5):1111-21. PMID: 20977460; PMCID: PMC2998691.
    70. Madadi P, Ito S. Perinatal exposure to maternal lamotrigine: clinical considerations for the mother and child. Can Fam Physician. 2010 Nov; 56(11):1132-4. PMID: 21075992; PMCID: PMC2980428.
    71. Chuang AI, Ito S. Ambient tonicity and intestinal cytochrome CYP3A. Expert Opin Drug Metab Toxicol. 2010 Aug; 6(8):883-93. PMID: 20374039.
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    72. Ito S, Carleton BC. Predictive genotype. CMAJ. 2010 May 18; 182(8):804. PMID: 20479057; PMCID: PMC2871209.
    73. Tan KP, Wang B, Yang M, Boutros PC, Macaulay J, Xu H, Chuang AI, Kosuge K, Yamamoto M, Takahashi S, Wu AM, Ross DD, Harper PA, Ito S. Aryl hydrocarbon receptor is a transcriptional activator of the human breast cancer resistance protein (BCRP/ABCG2). Mol Pharmacol. 2010 Aug; 78(2):175-85. PMID: 20460431.
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    74. Gunness P, Aleksa K, Kosuge K, Ito S, Koren G. Comparison of the novel HK-2 human renal proximal tubular cell line with the standard LLC-PK1 cell line in studying drug-induced nephrotoxicity. Can J Physiol Pharmacol. 2010 Apr; 88(4):448-55. PMID: 20555413.
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    75. Slessarev M, Prisman E, Ito S, Watson RR, Jensen D, Preiss D, Greene R, Norboo T, Stobdan T, Diskit D, Norboo A, Kunzang M, Appenzeller O, Duffin J, Fisher JA. Differences in the control of breathing between Himalayan and sea-level residents. J Physiol. 2010 May 01; 588(Pt 9):1591-606. PMID: 20194122; PMCID: PMC2876812.
    76. Lee CY, Ratnapalan S, Thompson M, Nathan PC, Closs J, French A, Punnett A, Garcia-Bournissen F, Ito S, Koren G. Unusual reactions to 5-HT3 receptor antagonists in a child with rhabdomyosarcoma. Can J Clin Pharmacol. 2010; 17(1):e1-4. PMID: 20051608.
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    77. Garcia-Bournissen F, Altcheh J, Panchaud A, Ito S. Is use of nifurtimox for the treatment of Chagas disease compatible with breast feeding? A population pharmacokinetics analysis. Arch Dis Child. 2010 Mar; 95(3):224-8. PMID: 19948512.
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    78. Madadi P, Moretti M, Djokanovic N, Bozzo P, Nulman I, Ito S, Koren G. Guidelines for maternal codeine use during breastfeeding. Can Fam Physician. 2009 Nov; 55(11):1077-8. PMID: 19910591; PMCID: PMC2776794.
    79. Lau AC, Duong TT, Ito S, Wilson GJ, Yeung RS. Inhibition of matrix metalloproteinase-9 activity improves coronary outcome in an animal model of Kawasaki disease. Clin Exp Immunol. 2009 Aug; 157(2):300-9. PMID: 19604270; PMCID: PMC2730856.
    80. Sakaguchi S, Garcia-Bournissen F, Kim R, Schwarz UI, Nathan PC, Ito S. Prolonged neutropenia after irinotecan-based chemotherapy in a child with polymorphisms of UGT1A1 and SLCO1B1. Arch Dis Child. 2009 Dec; 94(12):981-2. PMID: 19608554.
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    81. Lau AC, Duong TT, Ito S, Yeung RS. Intravenous immunoglobulin and salicylate differentially modulate pathogenic processes leading to vascular damage in a model of Kawasaki disease. Arthritis Rheum. 2009 Jul; 60(7):2131-41. PMID: 19565485.
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    82. Inoue M, Arata N, Koren G, Ito S. Hyperthyroidism during pregnancy. Can Fam Physician. 2009 Jul; 55(7):701-3. PMID: 19602653; PMCID: PMC2718594.
    83. Inoue M, Caldarone CA, Frndova H, Cox PN, Ito S, Taddio A, Guerguerian AM. Safety and efficacy of ketorolac in children after cardiac surgery. Intensive Care Med. 2009 Sep; 35(9):1584-92. PMID: 19562323.
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    84. Tanaka T, Nakajima K, Murashima A, Garcia-Bournissen F, Koren G, Ito S. Safety of neuraminidase inhibitors against novel influenza A (H1N1) in pregnant and breastfeeding women. CMAJ. 2009 Jul 07; 181(1-2):55-8. PMID: 19528139; PMCID: PMC2704420.
    85. Gijsen VM, de Wildt SN, Ito S. Probability of rash related to gabapentin therapy in a child. Ann Pharmacother. 2009 Feb; 43(2):387-9. PMID: 19193587.
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    86. Ito S. Breast cancer risk and history of being breast-fed. Epidemiology. 2009 Jan; 20(1):155. PMID: 19234405.
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    87. Ito S. Clinical investigation in pediatrics: challenges and opportunities in Toronto, Canada. Paediatr Drugs. 2009; 11(1):67-8. PMID: 19127960.
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    88. Tanaka T, Moretti ME, Verjee ZH, Shupak M, Ivanyi KE, Ito S. A pitfall of measuring lithium levels in neonates. Ther Drug Monit. 2008 Dec; 30(6):752-4. PMID: 19057375.
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    89. Levy S, Fayez I, Taguchi N, Han JY, Aiello J, Matsui D, Moretti M, Koren G, Ito S. Pregnancy outcome following in utero exposure to bisphosphonates. Bone. 2009 Mar; 44(3):428-30. PMID: 19059370.
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    90. Kozer E, Levichek Z, Hoshino N, Kapur B, Leombruno J, Taguchi N, Garcia-Bournissen F, Koren G, Ito S. The effect of amitriptyline, gabapentin, and carbamazepine on morphine-induced hypercarbia in rabbits. Anesth Analg. 2008 Oct; 107(4):1216-22. PMID: 18806030.
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    91. Tan KP, Kosuge K, Yang M, Ito S. NRF2 as a determinant of cellular resistance in retinoic acid cytotoxicity. Free Radic Biol Med. 2008 Dec 15; 45(12):1663-73. PMID: 18845239.
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    92. de Wildt SN, Ito S, Koren G. Challenges for drug studies in children: CYP3A phenotyping as example. Drug Discov Today. 2009 Jan; 14(1-2):6-15. PMID: 18721895.
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    93. Dubnov-Raz G, Juurlink DN, Fogelman R, Merlob P, Ito S, Koren G, Finkelstein Y. Antenatal use of selective serotonin-reuptake inhibitors and QT interval prolongation in newborns. Pediatrics. 2008 Sep; 122(3):e710-5. PMID: 18762507.
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    94. Barton M, Finkelstein Y, Opavsky MA, Ito S, Ho T, Ford-Jones LE, Taylor G, Benson L, Gold R. Eosinophilic myocarditis temporally associated with conjugate meningococcal C and hepatitis B vaccines in children. Pediatr Infect Dis J. 2008 Sep; 27(9):831-5. PMID: 18664932.
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    95. Taguchi N, Rubin ET, Hosokawa A, Choi J, Ying AY, Moretti ME, Koren G, Ito S. Prenatal exposure to HMG-CoA reductase inhibitors: effects on fetal and neonatal outcomes. Reprod Toxicol. 2008 Oct; 26(2):175-7. PMID: 18640262.
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    96. Choi J, Tanaka T, Koren G, Ito S. Lead exposure during breastfeeding. Can Fam Physician. 2008 Apr; 54(4):515-6. PMID: 18411377; PMCID: PMC2294082.
    97. Lau AC, Duong TT, Ito S, Yeung RS. Matrix metalloproteinase 9 activity leads to elastin breakdown in an animal model of Kawasaki disease. Arthritis Rheum. 2008 Mar; 58(3):854-63. PMID: 18311803.
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    98. De Rosa MF, Ackerley C, Wang B, Ito S, Clarke DM, Lingwood C. Inhibition of multidrug resistance by adamantylgb3, a globotriaosylceramide analog. J Biol Chem. 2008 Feb 22; 283(8):4501-11. PMID: 18003606.
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    99. Tan KP, Yang M, Ito S. Activation of nuclear factor (erythroid-2 like) factor 2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stress. Mol Pharmacol. 2007 Nov; 72(5):1380-90. PMID: 17724089.
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    100. Humphreys C, Garcia-Bournissen F, Ito S, Koren G. Exposure to attention deficit hyperactivity disorder medications during pregnancy. Can Fam Physician. 2007 Jul; 53(7):1153-5. PMID: 17872810; PMCID: PMC1949295.
    101. Kosuge K, Chuang AI, Uematsu S, Tan KP, Ohashi K, Ko BC, Ito S. Discovery of osmosensitive transcriptional regulation of human cytochrome P450 3As by the tonicity-responsive enhancer binding protein (nuclear factor of activated T cells 5). Mol Pharmacol. 2007 Oct; 72(4):826-37. PMID: 17600221.
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    102. Einarson A, Ito S. Re: use of contemporary antidepressants during breastfeeding: a proposal for a specific safety index. Drug Saf. 2007; 30(7):643; author reply 643-4. PMID: 17604423.
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    103. Garcia-Bournissen F, Boragina M, Ito S. Cytokine storm and an anti-CD28 monoclonal antibody. N Engl J Med. 2006 Dec 14; 355(24):2593; author reply 2593-4. PMID: 17167937.
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    104. Moretti ME, Verjee Z, Ito S, Koren G. Breast-feeding during maternal use of azathioprine. Ann Pharmacother. 2006 Dec; 40(12):2269-72. PMID: 17132809.
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    105. Cohen-Kerem R, Ratnapalan S, Djulus J, Duan X, Chandra RV, Ito S. The attitude of physicians toward cold remedies for upper respiratory infection in infants and children: a questionnaire survey. Clin Pediatr (Phila). 2006 Nov; 45(9):828-34. PMID: 17041170.
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    106. Aleksa K, Ito S, Koren G. Enantioselective metabolism of ifosfamide by the kidney. Chirality. 2006 Jun; 18(6):398-405. PMID: 16575879.
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    107. Houghton LA, Sherwood KL, Pawlosky R, Ito S, O'Connor DL. [6S]-5-Methyltetrahydrofolate is at least as effective as folic acid in preventing a decline in blood folate concentrations during lactation. Am J Clin Nutr. 2006 Apr; 83(4):842-50. PMID: 16600937.
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    108. Taguchi N, Ito S. Paternal use of ribavirin-interferon alpha 2B combination therapy before conception. Can Fam Physician. 2005 Dec; 51:1623-5. PMID: 16805078; PMCID: PMC1479501.
    109. Ito S, Kawano Y, Katakura H, Takenaka K, Adachi M, Sasaki M, Shimizu K, Ikenaka K, Wada H, Tanaka F. Expression of MAGE-D4, a novel MAGE family antigen, is correlated with tumor-cell proliferation of non-small cell lung cancer. Lung Cancer. 2006 Jan; 51(1):79-88. PMID: 16225959.
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    110. Kwok B, Yamauchi A, Rajesan R, Chan L, Dhillon U, Gao W, Xu H, Wang B, Takahashi S, Semple J, Tamai I, Nezu J, Tsuji A, Harper P, Ito S. Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A. Am J Physiol Regul Integr Comp Physiol. 2006 Mar; 290(3):R793-802. PMID: 16195500.
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    111. Xu H, Rajesan R, Harper P, Kim RB, Lonnerdal B, Yang M, Uematsu S, Hutson J, Watson-MacDonell J, Ito S. Induction of cytochrome P450 1A by cow milk-based formula: a comparative study between human milk and formula. Br J Pharmacol. 2005 Sep; 146(2):296-305. PMID: 15997229; PMCID: PMC1576269.
    112. Aleksa K, Halachmi N, Ito S, Koren G. A tubule cell model for ifosfamide nephrotoxicity. Can J Physiol Pharmacol. 2005 Jun; 83(6):499-508. PMID: 16049550.
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    113. Ivakine EA, Fox CJ, Paterson AD, Mortin-Toth SM, Canty A, Walton DS, Aleksa K, Ito S, Danska JS. Sex-specific effect of insulin-dependent diabetes 4 on regulation of diabetes pathogenesis in the nonobese diabetic mouse. J Immunol. 2005 Jun 01; 174(11):7129-40. PMID: 15905556.
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    114. Aleksa K, Matsell D, Krausz K, Gelboin H, Ito S, Koren G. Cytochrome P450 3A and 2B6 in the developing kidney: implications for ifosfamide nephrotoxicity. Pediatr Nephrol. 2005 Jul; 20(7):872-85. PMID: 15875221.
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    115. Rubin ET, Lee A, Ito S. When breastfeeding mothers need CNS-acting drugs. Can J Clin Pharmacol. 2004; 11(2):e257-66. PMID: 15591613.
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    116. Aleksa K, Halachmi N, Ito S, Koren G. Renal ontogeny of ifosfamide nephrotoxicity. J Lab Clin Med. 2004 Dec; 144(6):285-93. PMID: 15614250.
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    117. Lee A, Giesbrecht E, Dunn E, Ito S. Excretion of quetiapine in breast milk. Am J Psychiatry. 2004 Sep; 161(9):1715-6. PMID: 15337669.
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    118. Oren D, Nulman I, Makhija M, Ito S, Koren G. Using corticosteroids during pregnancy. Are topical, inhaled, or systemic agents associated with risk? Can Fam Physician. 2004 Aug; 50:1083-5. PMID: 15455804; PMCID: PMC2214644.
    119. Aleksa K, Ito S, Koren G. Renal-tubule metabolism of ifosfamide to the nephrotoxic chloroacetaldehyde: pharmacokinetic modeling for estimation of intracellular levels. J Lab Clin Med. 2004 Mar; 143(3):159-62. PMID: 15007305.
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    120. Ratnapalan S, Ito S. Pediatric resident education and needs assessment in clinical pharmacology. Can J Clin Pharmacol. 2004; 11(1):e150-5. PMID: 15300957.
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    121. Lee A, Woo J, Ito S. Frequency of infant adverse events that are associated with citalopram use during breast-feeding. Am J Obstet Gynecol. 2004 Jan; 190(1):218-21. PMID: 14749663.
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    122. Larsen LA, Ito S, Koren G. Prediction of milk/plasma concentration ratio of drugs. Ann Pharmacother. 2003 Sep; 37(9):1299-306. PMID: 12921514.
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    123. Ito S. Is CFTR dysfunction in cystic fibrosis compensated by MRPs? Pediatr Res. 2003 Nov; 54(5):625-6. PMID: 12930914.
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    124. Woodland C, Koren G, Wainer IW, Batist G, Ito S. Verapamil metabolites: potential P-glycoprotein-mediated multidrug resistance reversal agents. Can J Physiol Pharmacol. 2003 Aug; 81(8):800-5. PMID: 12897809.
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    125. Lee A, Minhas R, Matsuda N, Lam M, Ito S. The safety of St. John's wort (Hypericum perforatum) during breastfeeding. J Clin Psychiatry. 2003 Aug; 64(8):966-8. PMID: 12927015.
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    126. Phillips EJ, Rachlis AR, Ito S. Digoxin toxicity and ritonavir: a drug interaction mediated through p-glycoprotein? AIDS. 2003 Jul 04; 17(10):1577-8. PMID: 12824804.
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    127. Woodland C, Koren G, Ito S. From bench to bedside: utilization of an in vitro model to predict potential drug-drug interactions in the kidney: the digoxin-mifepristone example. J Clin Pharmacol. 2003 Jul; 43(7):743-50. PMID: 12856388.
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    128. Moretti ME, Sgro M, Johnson DW, Sauve RS, Woolgar MJ, Taddio A, Verjee Z, Giesbrecht E, Koren G, Ito S. Cyclosporine excretion into breast milk. Transplantation. 2003 Jun 27; 75(12):2144-6. PMID: 12829927.
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    129. Hosokawa A, Bar-Oz B, Ito S. Use of lipid-lowering agents (statins) during pregnancy. Can Fam Physician. 2003 Jun; 49:747-9. PMID: 12836860; PMCID: PMC2214243.
    130. Moretti ME, Koren G, Verjee Z, Ito S. Monitoring lithium in breast milk: an individualized approach for breast-feeding mothers. Ther Drug Monit. 2003 Jun; 25(3):364-6. PMID: 12766565.
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    131. Ito S, Lee A. Drug excretion into breast milk--overview. Adv Drug Deliv Rev. 2003 Apr 29; 55(5):617-27. PMID: 12706545.
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    132. Ito S, Alcorn J. Xenobiotic transporter expression and function in the human mammary gland. Adv Drug Deliv Rev. 2003 Apr 29; 55(5):653-65. PMID: 12706548.
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    133. Perri D, Ito S, Rowsell V, Shear NH. The kidney--the body's playground for drugs: an overview of renal drug handling with selected clinical correlates. Can J Clin Pharmacol. 2003; 10(1):17-23. PMID: 12687033.
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    134. Costei AM, Kozer E, Ho T, Ito S, Koren G. Perinatal outcome following third trimester exposure to paroxetine. Arch Pediatr Adolesc Med. 2002 Nov; 156(11):1129-32. PMID: 12413342.
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    135. Ito S. Transplacental treatment of fetal tachycardia: implications of drug transporting proteins in placenta. Semin Perinatol. 2001 Jun; 25(3):196-201. PMID: 11453617.
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    136. Woodland C, Ito S, Granvil CP, Wainer IW, Klein J, Koren G. Evidence of renal metabolism of ifosfamide to nephrotoxic metabolites. Life Sci. 2000 Nov 24; 68(1):109-17. PMID: 11132240.
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    137. Moretti ME, Lee A, Ito S. Which drugs are contraindicated during breastfeeding? Practice guidelines. Can Fam Physician. 2000 Sep; 46:1753-7. PMID: 11013791; PMCID: PMC2145042.
    138. Ito S. Drug therapy for breast-feeding women. N Engl J Med. 2000 Jul 13; 343(2):118-26. PMID: 10891521.
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    139. Lee A, Moretti ME, Collantes A, Chong D, Mazzotta P, Koren G, Merchant SS, Ito S. Choice of breastfeeding and physicians' advice: a cohort study of women receiving propylthiouracil. Pediatrics. 2000 Jul; 106(1 Pt 1):27-30. PMID: 10878145.
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    140. Tunzi CR, Harper PA, Bar-Oz B, Valore EV, Semple JL, Watson-MacDonell J, Ganz T, Ito S. Beta-defensin expression in human mammary gland epithelia. Pediatr Res. 2000 Jul; 48(1):30-5. PMID: 10879797.
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    141. Cowan KN, Heilbut A, Humpl T, Lam C, Ito S, Rabinovitch M. Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor. Nat Med. 2000 Jun; 6(6):698-702. PMID: 10835689.
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    142. Lala P, Ito S, Lingwood CA. Retroviral transfection of Madin-Darby canine kidney cells with human MDR1 results in a major increase in globotriaosylceramide and 10(5)- to 10(6)-fold increased cell sensitivity to verocytotoxin. Role of p-glycoprotein in glycolipid synthesis. J Biol Chem. 2000 Mar 03; 275(9):6246-51. PMID: 10692420.
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    143. Ito S. Drug secretion systems in renal tubular cells: functional models and molecular identity. Pediatr Nephrol. 1999 Nov; 13(9):980-8. PMID: 10603161.
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    144. Stiskal JA, Ito S, Cox DW, Shennan AT, O'Brien KK, Kelly EN, Longley TB, Rabinovitch M, Dunn MS. Functional and antigenic concentrations of alpha-1-proteinase inhibitor after administration for the prevention of chronic lung disease of prematurity. Biol Neonate. 1999 Sep; 76(3):134-43. PMID: 10460951.
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    145. Ito S, Woodland C, Sarkadi B, Hockmann G, Walker SE, Koren G. Modeling of P-glycoprotein-involved epithelial drug transport in MDCK cells. Am J Physiol. 1999 07; 277(1):F84-96. PMID: 10409301.
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    146. Loebstein R, Atanackovic G, Bishai R, Wolpin J, Khattak S, Hashemi G, Gobrial M, Baruchel S, Ito S, Koren G. Risk factors for long-term outcome of ifosfamide-induced nephrotoxicity in children. J Clin Pharmacol. 1999 May; 39(5):454-61. PMID: 10234592.
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    147. Koren G, Moretti M, Ito S. Continuing drug therapy while breastfeeding. Part 2. Common misconceptions of physicians. Can Fam Physician. 1999 May; 45:1173-5. PMID: 10349056; PMCID: PMC2328598.
    148. Ito S, Lieu M, Chan W, Koren G. Continuing drug therapy while breastfeeding. Part 1. Common misconceptions of patients. Can Fam Physician. 1999 Apr; 45:897-9. PMID: 10216783; PMCID: PMC2328303.
    149. Koren G, Ito S. Do silicone breast implants affect breastfeeding? Can Fam Physician. 1998 Dec; 44:2641-2. PMID: 9870113; PMCID: PMC2277793.
    150. Woodland C, Blowey D, Ito S, Spino M, Koren G. Hypothetical framework for enhanced renal tubular secretion of drugs in cystic fibrosis. Med Hypotheses. 1998 Dec; 51(6):489-91. PMID: 10052869.
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    151. Ito S, Gow R, Verjee Z, Giesbrecht E, Dodo H, Freedom R, Tonn GR, Axelson JE, Zalzstein E, Rosenberg HC, Koren G. Intravenous and oral propafenone for treatment of tachycardia in infants and children: pharmacokinetics and clinical response. J Clin Pharmacol. 1998 Jun; 38(6):496-501. PMID: 9650538.
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    152. Koren G, Pastuszak A, Ito S. Drugs in pregnancy. N Engl J Med. 1998 Apr 16; 338(16):1128-37. PMID: 9545362.
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    153. Woodland C, Ito S, Koren G. A model for the prediction of digoxin-drug interactions at the renal tubular cell level. Ther Drug Monit. 1998 Apr; 20(2):134-8. PMID: 9558126.
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    154. Koren G, Woodland C, Ito S. Toxic digoxin-drug interactions: the major role of renal P-glycoprotein. Vet Hum Toxicol. 1998 Feb; 40(1):45-6. PMID: 9467211.
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    155. Chattergoon DS, Verjee Z, Anderson M, Johnson D, McGuigan MA, Koren G, Ito S. Carbamazepine interference with an immune assay for tricyclic antidepressants in plasma. J Toxicol Clin Toxicol. 1998; 36(1-2):109-13. PMID: 9541055.
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    156. Stiskal JA, Dunn MS, Shennan AT, O'Brien KK, Kelly EN, Koppel RI, Cox DW, Ito S, Chappel SL, Rabinovitch M. alpha1-Proteinase inhibitor therapy for the prevention of chronic lung disease of prematurity: a randomized, controlled trial. Pediatrics. 1998 Jan; 101(1 Pt 1):89-94. PMID: 9417158.
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    157. Ito S, Weitzman S, Klein J, Greenberg M, Lau R, Atanakovic G, Koren G. Lack of cisplatin-ranitidine kinetic interactions: in vivo study in children, and in vitro study using dog renal brush border membrane vesicles. Life Sci. 1998; 62(25):PL387-92. PMID: 9651125.
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    158. Chattergoon DS, McGuigan MA, Koren G, Hwang P, Ito S. Multiorgan dysfunction and disseminated intravascular coagulation in children receiving lamotrigine and valproic acid. Neurology. 1997 Nov; 49(5):1442-4. PMID: 9371937.
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    159. Woodland C, Verjee Z, Giesbrecht E, Koren G, Ito S. The digoxin-propafenone interaction: characterization of a mechanism using renal tubular cell monolayers. J Pharmacol Exp Ther. 1997 Oct; 283(1):39-45. PMID: 9336306.
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    160. Bailey B, Ito S. Breast-feeding and maternal drug use. Pediatr Clin North Am. 1997 Feb; 44(1):41-54. PMID: 9057783.
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    161. Taddio A, Ito S, Koren G. Excretion of fluoxetine and its metabolite, norfluoxetine, in human breast milk. J Clin Pharmacol. 1996 Jan; 36(1):42-7. PMID: 8932542.
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    162. Johnson D, Eppler J, Giesbrecht E, Verjee Z, Rais A, Wiggins T, Fraga C, Ito S. Effect of multiple-dose activated charcoal on the clearance of high-dose intravenous aspirin in a porcine model. Ann Emerg Med. 1995 Nov; 26(5):569-74. PMID: 7486364.
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    163. Moretti ME, Ito S, Koren G. Disposition of maternal ketoconazole in breast milk. Am J Obstet Gynecol. 1995 Nov; 173(5):1625-6. PMID: 7503214.
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    164. Taddio A, Ito S, Einarson TR, Leeder JS, Koren G. Effect of counseling on maternal reporting of adverse effects in nursing infants exposed to antibiotics through breast milk. Reprod Toxicol. 1995 Mar-Apr; 9(2):153-7. PMID: 7795325.
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    165. Ito S, Moretti M, Liau M, Koren G. Initiation and duration of breast-feeding in women receiving antiepileptics. Am J Obstet Gynecol. 1995 Mar; 172(3):881-6. PMID: 7892879.
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    166. Ito S, Koren G. Estimation of fetal risk from aerosolized pentamidine in pregnant healthcare workers. Chest. 1994 Nov; 106(5):1460-2. PMID: 7956402.
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    167. Ito S, Magee L, Smallhorn J. Drug therapy for fetal arrhythmias. Clin Perinatol. 1994 Sep; 21(3):543-72. PMID: 7982334.
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    168. Ito S, Koren G. A novel index for expressing exposure of the infant to drugs in breast milk. Br J Clin Pharmacol. 1994 Aug; 38(2):99-102. PMID: 7981020; PMCID: PMC1364853.
    169. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May; 168(5):1393-9. PMID: 8498418.
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    170. Ito S, Koren G, Harper PA, Silverman M. Energy-dependent transport of digoxin across renal tubular cell monolayers (LLC-PK1). Can J Physiol Pharmacol. 1993 Jan; 71(1):40-7. PMID: 8099844.
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    171. Ito S, Woodland C, Harper PA, Koren G. P-glycoprotein-mediated renal tubular secretion of digoxin: the toxicological significance of the urine-blood barrier model. Life Sci. 1993; 53(2):PL25-31. PMID: 8100040.
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    172. Ito S, Woodland C, Harper PA, Koren G. The mechanism of the verapamil-digoxin interaction in renal tubular cells (LLC-PK1). Life Sci. 1993; 53(24):PL399-403. PMID: 8246676.
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    173. Ito S, Koren G. Exposure of pregnant women to ribavirin-contaminated air: risk assessment and recommendations. Pediatr Infect Dis J. 1993 Jan; 12(1):2-5. PMID: 8417419.
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    174. Ito S, Koren G, Einarson TR. Maternal noncompliance with antibiotics during breastfeeding. Ann Pharmacother. 1993 Jan; 27(1):40-2. PMID: 8431618.
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    175. Ito S, Koren G, Harper PA. Handling of digoxin and ouabain by renal tubular cells (LLC-PK1). J Pharmacol Exp Ther. 1992 Jul; 262(1):109-13. PMID: 1320681.
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    176. Matsui D, Hermann C, Braudo M, Ito S, Olivieri N, Koren G. Clinical use of the Medication Event Monitoring System: a new window into pediatric compliance. Clin Pharmacol Ther. 1992 Jul; 52(1):102-3. PMID: 1623684.
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    177. Tsao PW, Ito S, Wong PY, Radde IC, Bryson S, Young DS, Caspi J, Diaz RJ, Martell MF, Augustine JM, et al. Pharmacodynamics and pharmacokinetics of cyclosporin A in the newborn pig. Dev Pharmacol Ther. 1992; 18(1-2):20-5. PMID: 1483359.
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    178. Ito S, Harper PA, Koren G. Renal tubular cell handling of digoxin and ouabain--in vitro study using LLC-PK1 cell lines. Toxicol Lett. 1990 Sep; 53(1-2):189-91. PMID: 2219165.
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