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John Brumell

TitleSenior Scientist
InstitutionThe Hospital for Sick Children
DepartmentCell Biology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Biography 
    Collapse education and training
    University of Western Ontario, London, ON, CanadaBSc06/1992Biochemistry
    University of Toronto , Toronto, ON, CanadaPhD08/1997Biochemistry
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, CanadaPostdoc08/1998Biochemistry
    University of British Columbia, Vancouver, BC, Canada Postdoc08/2002Microbiology
    Collapse awards and honors
    1994Scholarship, PGS-B , Natural Sciences and Engineering Research Council of Canada
    1995Annual Meeting Travel Award , American Society for Cell Biology
    1196Annual Meeting Travel Award , American Society for Cell Biology
    1996Joseph Connolly Award for Cell Biology, Dept. of Anatomy and Cell Biology, University of Toronto
    1996Research Training Committee Studentship, Research Institute, The Hospital for Sick Children
    1997Postdoctoral Fellowship, Natural Sciences & Engineering Research Council
    1998Izaac Walter Killam Honourary postdoctoral fellowship
    1999Postdoctoral Fellowship, Canadian Institutes of Health Research
    2002 New Investigator Award , Canadian Institutes of Health Research
    2004Ontario Premier’s Research Excellence Award (PREA)
    2005Burroughs Wellcome Fund Investigators in Pathogenesis of Infectious Disease Award.
    2005Young Investigator Award in Biological Sciences, Boehringer Ingelheim (Canada)
    2009Young Investigator Award , Canadian Association of Gastroenterology (CAG)
    2009Fisher Scientific Award , Canadian Society of Microbiologists (CSM)
    2012GE Healthcare New Investigator Award , Canadian Society for Molecular Biosciences
    2014 - 2024Pitblado Chair in Cell Biology, Hospital for Sick Children and University of Toronto

    Collapse Overview 
    Collapse overview



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Lu Y, Zheng Y, Coyaud É, Zhang C, Selvabaskaran A, Yu Y, Xu Z, Weng X, Chen JS, Meng Y, Warner N, Cheng X, Liu Y, Yao B, Hu H, Xia Z, Muise AM, Klip A, Brumell JH, Girardin SE, Ying S, Fairn GD, Raught B, Sun Q, Neculai D. Palmitoylation of NOD1 and NOD2 is required for bacterial sensing. Science. 2019 10 25; 366(6464):460-467. PMID: 31649195.
      View in: PubMed
    2. D'Costa VM, Coyaud E, Boddy KC, Laurent EMN, St-Germain J, Li T, Grinstein S, Raught B, Brumell JH. BioID screen of Salmonella type 3 secreted effectors reveals host factors involved in vacuole positioning and stability during infection. Nat Microbiol. 2019 Oct 14. PMID: 31611645.
      View in: PubMed
    3. Frendo-Cumbo S, Jaldin-Fincati JR, Coyaud E, Laurent EMN, Townsend LK, Tan JMJ, Xavier RJ, Pillon NJ, Raught B, Wright DC, Brumell JH, Klip A. Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation. J Biol Chem. 2019 Nov 01; 294(44):16172-16185. PMID: 31515271.
      View in: PubMed
    4. Tan JMJ, Mellouk N, Brumell JH. An autophagy-independent role for ATG16L1: promoting lysosome-mediated plasma membrane repair. Autophagy. 2019 May; 15(5):932-933. PMID: 30806149.
      View in: PubMed
    5. Tan JMJ, Mellouk N, Osborne SE, Ammendolia DA, Dyer DN, Li R, Brunen D, van Rijn JM, Huang J, Czuczman MA, Cemma MA, Won AM, Yip CM, Xavier RJ, MacDuff DA, Reggiori F, Debnath J, Yoshimori T, Kim PK, Fairn GD, Coyaud E, Raught B, Muise AM, Higgins DE, Brumell JH. An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread. Nat Microbiol. 2018 12; 3(12):1472-1485. PMID: 30478389.
      View in: PubMed
    6. Truong D, Boddy KC, Canadien V, Brabant D, Fairn GD, D'Costa VM, Coyaud E, Raught B, Pérez-Sala D, Park WS, Heo WD, Grinstein S, Brumell JH. Salmonella exploits host Rho GTPase signalling pathways through the phosphatase activity of SopB. Cell Microbiol. 2018 10; 20(10):e12938. PMID: 30010242.
      View in: PubMed
    7. Boddy KC, Gao AD, Truong D, Kim MS, Froese CD, Trimble WS, Brumell JH. Septin-regulated actin dynamics promote Salmonella invasion of host cells. Cell Microbiol. 2018 10; 20(10):e12866. PMID: 29885024.
      View in: PubMed
    8. Coyaud E, Ranadheera C, Cheng D, Gonçalves J, Dyakov BJA, Laurent EMN, St-Germain J, Pelletier L, Gingras AC, Brumell JH, Kim PK, Safronetz D, Raught B. Global Interactomics Uncovers Extensive Organellar Targeting by Zika Virus. Mol Cell Proteomics. 2018 11; 17(11):2242-2255. PMID: 30037810.
      View in: PubMed
    9. Ghosh P, Halvorsen EM, Ammendolia DA, Mor-Vaknin N, O'Riordan MXD, Brumell JH, Markovitz DM, Higgins DE. Invasion of the Brain by Listeria monocytogenes Is Mediated by InlF and Host Cell Vimentin. MBio. 2018 02 27; 9(1). PMID: 29487235.
      View in: PubMed
    10. Osborne SE, Brumell JH. Listeriolysin O: from bazooka to Swiss army knife. Philos Trans R Soc Lond B Biol Sci. 2017 Aug 05; 372(1726). PMID: 28630160.
      View in: PubMed
    11. Wang A, Carraro-Lacroix LR, Owen C, Gao B, Corey PN, Tyrrell P, Brumell JH, Voronov I. Activity-independent targeting of mTOR to lysosomes in primary osteoclasts. Sci Rep. 2017 06 07; 7(1):3005. PMID: 28592812.
      View in: PubMed
    12. Law KB, Bronte-Tinkew D, Di Pietro E, Snowden A, Jones RO, Moser A, Brumell JH, Braverman N, Kim PK. The peroxisomal AAA ATPase complex prevents pexophagy and development of peroxisome biogenesis disorders. Autophagy. 2017 May 04; 13(5):868-884. PMID: 28521612.
      View in: PubMed
    13. Kahr WH, Pluthero FG, Elkadri A, Warner N, Drobac M, Chen CH, Lo RW, Li L, Li R, Li Q, Thoeni C, Pan J, Leung G, Lara-Corrales I, Murchie R, Cutz E, Laxer RM, Upton J, Roifman CM, Yeung RS, Brumell JH, Muise AM. Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease. Nat Commun. 2017 04 03; 8:14816. PMID: 28368018.
      View in: PubMed
    14. Hua R, Cheng D, Coyaud É, Freeman S, Di Pietro E, Wang Y, Vissa A, Yip CM, Fairn GD, Braverman N, Brumell JH, Trimble WS, Raught B, Kim PK. VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis. J Cell Biol. 2017 02; 216(2):367-377. PMID: 28108526.
      View in: PubMed
    15. Osborne SE, Sit B, Shaker A, Currie E, Tan JM, van Rijn J, Higgins DE, Brumell JH. Type I interferon promotes cell-to-cell spread of Listeria monocytogenes. Cell Microbiol. 2017 03; 19(3). PMID: 27582004.
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    16. Cemma M, Grinstein S, Brumell JH. Autophagy proteins are not universally required for phagosome maturation. Autophagy. 2016 09; 12(9):1440-6. PMID: 27310610.
      View in: PubMed
    17. Dolma S, Selvadurai HJ, Lan X, Lee L, Kushida M, Voisin V, Whetstone H, So M, Aviv T, Park N, Zhu X, Xu C, Head R, Rowland KJ, Bernstein M, Clarke ID, Bader G, Harrington L, Brumell JH, Tyers M, Dirks PB. Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell. 2016 06 13; 29(6):859-873. PMID: 27300435.
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    18. Li Q, Lee CH, Peters LA, Mastropaolo LA, Thoeni C, Elkadri A, Schwerd T, Zhu J, Zhang B, Zhao Y, Hao K, Dinarzo A, Hoffman G, Kidd BA, Murchie R, Al Adham Z, Guo C, Kotlarz D, Cutz E, Walters TD, Shouval DS, Curran M, Dobrin R, Brodmerkel C, Snapper SB, Klein C, Brumell JH, Hu M, Nanan R, Snanter-Nanan B, Wong M, Le Deist F, Haddad E, Roifman CM, Deslandres C, Griffiths AM, Gaskin KJ, Uhlig HH, Schadt EE, Muise AM. Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease. Gastroenterology. 2016 05; 150(5):1196-1207. PMID: 26836588.
      View in: PubMed
    19. Hu Y, Carraro-Lacroix LR, Wang A, Owen C, Bajenova E, Corey PN, Brumell JH, Voronov I. Lysosomal pH Plays a Key Role in Regulation of mTOR Activity in Osteoclasts. J Cell Biochem. 2016 Feb; 117(2):413-25. PMID: 26212375.
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    20. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
      View in: PubMed
    21. Hayes P, Dhillon S, O'Neill K, Thoeni C, Hui KY, Elkadri A, Guo CH, Kovacic L, Aviello G, Alvarez LA, Griffiths AM, Snapper SB, Brant SR, Doroshow JH, Silverberg MS, Peter I, McGovern DP, Cho J, Brumell JH, Uhlig HH, Bourke B, Muise AA, Knaus UG. Defects in NADPH Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease. Cell Mol Gastroenterol Hepatol. 2015 Sep 01; 1(5):489-502. PMID: 26301257.
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    22. Sit B, Crowley SM, Bhullar K, Lai CC, Tang C, Hooda Y, Calmettes C, Khambati H, Ma C, Brumell JH, Schryvers AB, Vallance BA, Moraes TF. Active Transport of Phosphorylated Carbohydrates Promotes Intestinal Colonization and Transmission of a Bacterial Pathogen. PLoS Pathog. 2015 Aug; 11(8):e1005107. PMID: 26295949.
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    23. D'Costa VM, Braun V, Landekic M, Shi R, Proteau A, McDonald L, Cygler M, Grinstein S, Brumell JH. Salmonella Disrupts Host Endocytic Trafficking by SopD2-Mediated Inhibition of Rab7. Cell Rep. 2015 Sep 01; 12(9):1508-18. PMID: 26299973.
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    24. Cemma M, Lam GY, Stöckli M, Higgins DE, Brumell JH. Strain-Specific Interactions of Listeria monocytogenes with the Autophagy System in Host Cells. PLoS One. 2015; 10(5):e0125856. PMID: 25970638.
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    25. Fattouh R, Kwon H, Czuczman MA, Copeland JW, Pelletier L, Quinlan ME, Muise AM, Higgins DE, Brumell JH. The diaphanous-related formins promote protrusion formation and cell-to-cell spread of Listeria monocytogenes. J Infect Dis. 2015 Apr 01; 211(7):1185-95. PMID: 25281757.
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    26. Dhillon SS, Fattouh R, Elkadri A, Xu W, Murchie R, Walters T, Guo C, Mack D, Huynh HQ, Baksh S, Silverberg MS, Griffiths AM, Snapper SB, Brumell JH, Muise AM. Variants in nicotinamide adenine dinucleotide phosphate oxidase complex components determine susceptibility to very early onset inflammatory bowel disease. Gastroenterology. 2014 Sep; 147(3):680-689.e2. PMID: 24931457.
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    27. Truong D, Copeland JW, Brumell JH. Bacterial subversion of host cytoskeletal machinery: hijacking formins and the Arp2/3 complex. Bioessays. 2014 Jul; 36(7):687-96. PMID: 24849003.
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    28. Costford SR, Castro-Alves J, Chan KL, Bailey LJ, Woo M, Belsham DD, Brumell JH, Klip A. Mice lacking NOX2 are hyperphagic and store fat preferentially in the liver. Am J Physiol Endocrinol Metab. 2014 Jun 15; 306(12):E1341-53. PMID: 24760992.
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    29. Czuczman MA, Fattouh R, van Rijn JM, Canadien V, Osborne S, Muise AM, Kuchroo VK, Higgins DE, Brumell JH. Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread. Nature. 2014 May 08; 509(7499):230-4. PMID: 24739967.
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    30. Zhang L, Chen X, Sharma P, Moon M, Sheftel AD, Dawood F, Nghiem MP, Wu J, Li RK, Gramolini AO, Sorensen PH, Penninger JM, Brumell JH, Liu PP. HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. Nat Commun. 2014 Mar 11; 5:3430. PMID: 24614889.
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    31. Dhillon SS, Mastropaolo LA, Murchie R, Griffiths C, Thöni C, Elkadri A, Xu W, Mack A, Walters T, Guo C, Mack D, Huynh H, Baksh S, Silverberg MS, Brumell JH, Snapper SB, Muise AM. Higher activity of the inducible nitric oxide synthase contributes to very early onset inflammatory bowel disease. Clin Transl Gastroenterol. 2014 Jan 16; 5:e46. PMID: 24430113.
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    32. Avitzur Y, Guo C, Mastropaolo LA, Bahrami E, Chen H, Zhao Z, Elkadri A, Dhillon S, Murchie R, Fattouh R, Huynh H, Walker JL, Wales PW, Cutz E, Kakuta Y, Dudley J, Kammermeier J, Powrie F, Shah N, Walz C, Nathrath M, Kotlarz D, Puchaka J, Krieger JR, Racek T, Kirchner T, Walters TD, Brumell JH, Griffiths AM, Rezaei N, Rashtian P, Najafi M, Monajemzadeh M, Pelsue S, McGovern DP, Uhlig HH, Schadt E, Klein C, Snapper SB, Muise AM. Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease. Gastroenterology. 2014 Apr; 146(4):1028-39. PMID: 24417819.
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    33. Huang J, Brumell JH. Bacteria-autophagy interplay: a battle for survival. Nat Rev Microbiol. 2014 Feb; 12(2):101-14. PMID: 24384599.
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    34. Roppenser B, Kwon H, Canadien V, Xu R, Devreotes PN, Grinstein S, Brumell JH. Multiple host kinases contribute to Akt activation during Salmonella infection. PLoS One. 2013; 8(8):e71015. PMID: 23990921.
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    35. Truong D, Brabant D, Bashkurov M, Wan LC, Braun V, Heo WD, Meyer T, Pelletier L, Copeland J, Brumell JH. Formin-mediated actin polymerization promotes Salmonella invasion. Cell Microbiol. 2013 Dec; 15(12):2051-63. PMID: 23869992.
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    36. Chaturvedi S, Yuen DA, Bajwa A, Huang YW, Sokollik C, Huang L, Lam GY, Tole S, Liu GY, Pan J, Chan L, Sokolskyy Y, Puthia M, Godaly G, John R, Wang C, Lee WL, Brumell JH, Okusa MD, Robinson LA. Slit2 prevents neutrophil recruitment and renal ischemia-reperfusion injury. J Am Soc Nephrol. 2013 Jul; 24(8):1274-87. PMID: 23766538.
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    37. Hu P, Muise AM, Xing X, Brumell JH, Silverberg MS, Xu W. Association between a multi-locus genetic risk score and inflammatory bowel disease. Bioinform Biol Insights. 2013; 7:143-52. PMID: 23761965.
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    38. Fattouh R, Guo CH, Lam GY, Gareau MG, Ngan BY, Glogauer M, Muise AM, Brumell JH. Rac2-deficiency leads to exacerbated and protracted colitis in response to Citrobacter rodentium infection. PLoS One. 2013; 8(4):e61629. PMID: 23613889.
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    39. Lam GY, Cemma M, Muise AM, Higgins DE, Brumell JH. Host and bacterial factors that regulate LC3 recruitment to Listeria monocytogenes during the early stages of macrophage infection. Autophagy. 2013 Jul; 9(7):985-95. PMID: 23584039.
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    40. Cemma M, Brumell JH. Immunology. Bacterial escape artists set afire. Science. 2013 Feb 22; 339(6122):912-3. PMID: 23430642.
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    41. Mrakovic A, Kay JG, Furuya W, Brumell JH, Botelho RJ. Rab7 and Arl8 GTPases are necessary for lysosome tubulation in macrophages. Traffic. 2012 Dec; 13(12):1667-79. PMID: 22909026.
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    42. Mijaljica D, Nazarko TY, Brumell JH, Huang WP, Komatsu M, Prescott M, Simonsen A, Yamamoto A, Zhang H, Klionsky DJ, Devenish RJ. Receptor protein complexes are in control of autophagy. Autophagy. 2012 Nov; 8(11):1701-5. PMID: 22874568.
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    43. Tyler AD, Milgrom R, Stempak JM, Xu W, Brumell JH, Muise AM, Sehgal R, Cohen Z, Koltun W, Shen B, Silverberg MS. The NOD2insC polymorphism is associated with worse outcome following ileal pouch-anal anastomosis for ulcerative colitis. Gut. 2013 Oct; 62(10):1433-9. PMID: 22879519.
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    44. Cemma M, Brumell JH. Interactions of pathogenic bacteria with autophagy systems. Curr Biol. 2012 Jul 10; 22(13):R540-5. PMID: 22790007.
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    108. Harrison RE, Brumell JH, Khandani A, Bucci C, Scott CC, Jiang X, Finlay BB, Grinstein S. Salmonella impairs RILP recruitment to Rab7 during maturation of invasion vacuoles. Mol Biol Cell. 2004 Jul; 15(7):3146-54. PMID: 15121880.
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    109. Brumell JH, Grinstein S. Salmonella redirects phagosomal maturation. Curr Opin Microbiol. 2004 Feb; 7(1):78-84. PMID: 15036145.
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    110. Brumell JH, Grinstein S. Role of lipid-mediated signal transduction in bacterial internalization. Cell Microbiol. 2003 May; 5(5):287-97. PMID: 12713488.
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    111. Brumell JH, Kujat-Choy S, Brown NF, Vallance BA, Knodler LA, Finlay BB. SopD2 is a novel type III secreted effector of Salmonella typhimurium that targets late endocytic compartments upon delivery into host cells. Traffic. 2003 Jan; 4(1):36-48. PMID: 12535274.
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    112. Brumell JH, Goosney DL, Finlay BB. SifA, a type III secreted effector of Salmonella typhimurium, directs Salmonella-induced filament (Sif) formation along microtubules. Traffic. 2002 Jun; 3(6):407-15. PMID: 12010459.
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    113. Brumell JH, Tang P, Zaharik ML, Finlay BB. Disruption of the Salmonella-containing vacuole leads to increased replication of Salmonella enterica serovar typhimurium in the cytosol of epithelial cells. Infect Immun. 2002 Jun; 70(6):3264-70. PMID: 12011022.
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    114. Brumell JH, Perrin AJ, Goosney DL, Finlay BB. Microbial pathogenesis: new niches for salmonella. Curr Biol. 2002 Jan 08; 12(1):R15-7. PMID: 11790317.
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    115. Steele-Mortimer O, Brumell JH, Knodler LA, Méresse S, Lopez A, Finlay BB. The invasion-associated type III secretion system of Salmonella enterica serovar Typhimurium is necessary for intracellular proliferation and vacuole biogenesis in epithelial cells. Cell Microbiol. 2002 Jan; 4(1):43-54. PMID: 11856172.
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    116. Brumell JH, Tang P, Mills SD, Finlay BB. Characterization of Salmonella-induced filaments (Sifs) reveals a delayed interaction between Salmonella-containing vacuoles and late endocytic compartments. Traffic. 2001 Sep; 2(9):643-53. PMID: 11555418.
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    117. Brumell JH, Rosenberger CM, Gotto GT, Marcus SL, Finlay BB. SifA permits survival and replication of Salmonella typhimurium in murine macrophages. Cell Microbiol. 2001 Feb; 3(2):75-84. PMID: 11207622.
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    118. Coppolino MG, Kong C, Mohtashami M, Schreiber AD, Brumell JH, Finlay BB, Grinstein S, Trimble WS. Requirement for N-ethylmaleimide-sensitive factor activity at different stages of bacterial invasion and phagocytosis. J Biol Chem. 2001 Feb 16; 276(7):4772-80. PMID: 11092884.
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    119. Rosenberger CM, Brumell JH, Finlay BB. Microbial pathogenesis: lipid rafts as pathogen portals. Curr Biol. 2000 Nov 16; 10(22):R823-5. PMID: 11102822.
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    120. Finlay BB, Brumell JH. Salmonella interactions with host cells: in vitro to in vivo. Philos Trans R Soc Lond B Biol Sci. 2000 May 29; 355(1397):623-31. PMID: 10874735.
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    121. Brumell JH, Marcus SL, Finlay BB. N-terminal conservation of putative type III secreted effectors of Salmonella typhimurium. Mol Microbiol. 2000 May; 36(3):773-4. PMID: 10844665.
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    122. Marcus SL, Brumell JH, Pfeifer CG, Finlay BB. Salmonella pathogenicity islands: big virulence in small packages. Microbes Infect. 2000 Feb; 2(2):145-56. PMID: 10742687.
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    123. Brumell JH, Howard JC, Craig K, Grinstein S, Schreiber AD, Tyers M. Expression of the protein kinase C substrate pleckstrin in macrophages: association with phagosomal membranes. J Immunol. 1999 Sep 15; 163(6):3388-95. PMID: 10477609.
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    124. Brumell JH, Steele-Mortimer O, Finlay BB. Bacterial invasion: Force feeding by Salmonella. Curr Biol. 1999 Apr 22; 9(8):R277-80. PMID: 10226015.
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    125. Kiefer F, Brumell J, Al-Alawi N, Latour S, Cheng A, Veillette A, Grinstein S, Pawson T. The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils. Mol Cell Biol. 1998 Jul; 18(7):4209-20. PMID: 9632805.
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    126. Brumell JH, Craig KL, Ferguson D, Tyers M, Grinstein S. Phosphorylation and subcellular redistribution of pleckstrin in human neutrophils. J Immunol. 1997 May 15; 158(10):4862-71. PMID: 9144502.
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    127. Brumell JH, Chan CK, Butler J, Borregaard N, Siminovitch KA, Grinstein S, Downey GP. Regulation of Src homology 2-containing tyrosine phosphatase 1 during activation of human neutrophils. Role of protein kinase C. J Biol Chem. 1997 Jan 10; 272(2):875-82. PMID: 8995376.
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    128. Downey GP, Butler JR, Brumell J, Borregaard N, Kjeldsen L, Sue-A-Quan AK, Grinstein S. Chemotactic peptide-induced activation of MEK-2, the predominant isoform in human neutrophils. Inhibition by wortmannin. J Biol Chem. 1996 Aug 30; 271(35):21005-1011. PMID: 8702863.
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    129. Nanda A, Brumell JH, Nordström T, Kjeldsen L, Sengelov H, Borregaard N, Rotstein OD, Grinstein S. Activation of proton pumping in human neutrophils occurs by exocytosis of vesicles bearing vacuolar-type H+-ATPases. J Biol Chem. 1996 Jul 05; 271(27):15963-70. PMID: 8663143.
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    130. Brumell JH, Burkhardt AL, Bolen JB, Grinstein S. Endogenous reactive oxygen intermediates activate tyrosine kinases in human neutrophils. J Biol Chem. 1996 Jan 19; 271(3):1455-61. PMID: 8576138.
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    131. Brumell JH, Volchuk A, Sengelov H, Borregaard N, Cieutat AM, Bainton DF, Grinstein S, Klip A. Subcellular distribution of docking/fusion proteins in neutrophils, secretory cells with multiple exocytic compartments. J Immunol. 1995 Dec 15; 155(12):5750-9. PMID: 7499863.
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    132. Brumell JH, Grinstein S. Serine/threonine kinase activation in human neutrophils: relationship to tyrosine phosphorylation. Am J Physiol. 1994 Dec; 267(6 Pt 1):C1574-81. PMID: 7810598.
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