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Sevan Hopyan

TitleSurgeon
InstitutionThe Hospital for Sick Children
DepartmentOrthopaedic Surgery
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hopyan S. Reconstruction for bone tumours of the shoulder and humerus in children and adolescents. J Child Orthop. 2021 Aug 20; 15(4):358-365. PMID: 34476025.
      View in: PubMed
    2. Renzi S, Cullinan N, Cohen-Gogo S, Langenberg-Ververgaert K, Michaeli O, Alkendi J, Kanwar N, Lo W, Villani A, Shlien A, Malkin D, Ryan AL, Gallinger B, Ingley K, Hopyan S, Gupta A, Chami R. Non-rhabdomyosarcoma soft tissue sarcomas diagnosed in patients at a young age. An overview of clinical, pathological, and molecular findings. Pediatr Blood Cancer. 2021 Aug; 68(8):e29022. PMID: 33764675.
      View in: PubMed
    3. Fonseca A, Ryan AL, Gibson P, Hendershot E, Hopyan S, Ranson M, Stimec J, Gupta AA. Radiological Assessment and Outcome of Local Disease Progression after Neoadjuvant Chemotherapy in Children and Adolescents with Localized Osteosarcoma. J Clin Med. 2020 Dec 17; 9(12). PMID: 33348627.
      View in: PubMed
    4. Tao H, Lambert JP, Yung TM, Zhu M, Hahn NA, Li D, Lau K, Sturgeon K, Puviindran V, Zhang X, Gong W, Chen XX, Anderson G, Garry DJ, Henkelman RM, Sun Y, Iulianella A, Kawakami Y, Gingras AC, Hui CC, Hopyan S. IRX3/5 regulate mitotic chromatid segregation and limb bud shape. Development. 2020 10 05; 147(19). PMID: 32907847.
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    5. Zhu M, Zhang K, Tao H, Hopyan S, Sun Y. Magnetic Micromanipulation for In Vivo Measurement of Stiffness Heterogeneity and Anisotropy in the Mouse Mandibular Arch. Research (Wash D C). 2020; 2020:7914074. PMID: 32666052.
      View in: PubMed
    6. Rao-Bhatia A, Zhu M, Yin WC, Coquenlorge S, Zhang X, Woo J, Sun Y, Dean CH, Liu A, Hui CC, Shivdasani RA, McNeill H, Hopyan S, Kim TH. Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development. Dev Cell. 2020 03 09; 52(5):647-658.e6. PMID: 32155439.
      View in: PubMed
    7. Zhu M, Tao H, Samani M, Luo M, Wang X, Hopyan S, Sun Y. Spatial mapping of tissue properties in vivo reveals a 3D stiffness gradient in the mouse limb bud. Proc Natl Acad Sci U S A. 2020 03 03; 117(9):4781-4791. PMID: 32071242.
      View in: PubMed
    8. Piscione J, Barden W, Barry J, Malkin A, Roy T, Sueyoshi T, Mazil K, Salomon S, Dandachli F, Griffin A, Saint-Yves H, Giuliano P, Gupta A, Ferguson P, Scheinemann K, Ghert M, Turcotte RE, Lafay-Cousin L, Werier J, Strahlendorf C, Isler M, Mottard S, Afzal S, Anderson ME, Hopyan S. The Pediatric Toronto Extremity Salvage Score (pTESS): Validation of a Self-reported Functional Outcomes Tool for Children with Extremity Tumors. Clin Orthop Relat Res. 2019 Sep; 477(9):2127-2141. PMID: 31299028.
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    9. Westacott D, Kannu P, Stimec J, Hopyan S, Howard A. Osteofibrous Dysplasia of the Tibia in Children: Outcome Without Resection. J Pediatr Orthop. 2019 Sep; 39(8):e614-e621. PMID: 31393304.
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    10. Alsharief AN, Martinez-Rios C, Hopyan S, Amirabadi A, Doria AS, Greer MC. Usefulness of diffusion-weighted MRI in the initial assessment of osseous sarcomas in children and adolescents. Pediatr Radiol. 2019 08; 49(9):1201-1208. PMID: 31203404.
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    11. Tao H, Zhu M, Lau K, Whitley OKW, Samani M, Xiao X, Chen XX, Hahn NA, Liu W, Valencia M, Wu M, Wang X, Fenelon KD, Pasiliao CC, Hu D, Wu J, Spring S, Ferguson J, Karuna EP, Henkelman RM, Dunn A, Huang H, Ho HH, Atit R, Goyal S, Sun Y, Hopyan S. Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch. Nat Commun. 2019 04 12; 10(1):1703. PMID: 30979871.
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    12. Wang X, Ho C, Tsatskis Y, Law J, Zhang Z, Zhu M, Dai C, Wang F, Tan M, Hopyan S, McNeill H, Sun Y. Intracellular manipulation and measurement with multipole magnetic tweezers. Sci Robot. 2019 03 13; 4(28). PMID: 33137746.
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    13. Renzi S, Langenberg-Ververgaert K, Fuligni F, Ryan AL, Davidson S, Anderson N, Hayes R, Hopyan S, Gerstle JT, Shago M, Chami R, Malkin D, Shlien A, Villani A, Gupta AA. Aggressive embryonal rhabdomyosarcoma in a 3-month-old boy: A clinical and molecular analysis. Pediatr Hematol Oncol. 2018 Oct - Nov; 35(7-8):407-414. PMID: 30806137.
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    14. Ho ES, Zuccaro J, Klar K, Anthony A, Davidge K, Borschel GH, Hopyan S, Clarke HM, Wright FV. Effectiveness of non-surgical and surgical interventions for elbow flexion contractures in brachial plexus birth injury: A systematic review. J Pediatr Rehabil Med. 2019; 12(1):87-100. PMID: 30883375.
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    15. Ho ES, Kim D, Klar K, Anthony A, Davidge K, Borschel GH, Hopyan S, Clarke HM, Wright FV. Prevalence and etiology of elbow flexion contractures in brachial plexus birth injury: A scoping review. J Pediatr Rehabil Med. 2019; 12(1):75-86. PMID: 31006697.
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    16. Holmquist Mengelbier L, Lindell-Munther S, Yasui H, Jansson C, Esfandyari J, Karlsson J, Lau K, Hui CC, Bexell D, Hopyan S, Gisselsson D. The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in Wilms tumour development and human nephrogenesis. J Pathol. 2019 01; 247(1):86-98. PMID: 30246301.
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    17. Wang X, Zhang Z, Tao H, Liu J, Hopyan S, Sun Y. Characterizing Inner Pressure and Stiffness of Trophoblast and Inner Cell Mass of Blastocysts. Biophys J. 2018 12 18; 115(12):2443-2450. PMID: 30509858.
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    18. Renzi S, Tsimerman E, Taylor T, Hopyan S, Koo A, Gupta A. Concomitant Administration of High-dose Methotrexate and Low-dose Aspirin Without Any Delay in Methotrexate Clearance in a Patient With Osteosarcoma: A Case Report and Review of the Literature. J Pediatr Hematol Oncol. 2018 08; 40(6):e392-e393. PMID: 28902079.
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    19. Wang X, Liu H, Zhu M, Cao C, Xu Z, Tsatskis Y, Lau K, Kuok C, Filleter T, McNeill H, Simmons CA, Hopyan S, Sun Y. Mechanical stability of the cell nucleus - roles played by the cytoskeleton in nuclear deformation and strain recovery. J Cell Sci. 2018 07 04; 131(13). PMID: 29777038.
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    20. Ho ES, Klar K, Klar E, Davidge K, Hopyan S, Clarke HM. Elbow flexion contractures in brachial plexus birth injury: function and appearance related factors. Disabil Rehabil. 2019 11; 41(22):2648-2652. PMID: 29788784.
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    21. Deimling SJ, Lau K, Hui CC, Hopyan S. Genetic interaction between Gli3 and Ezh2 during limb pattern formation. Mech Dev. 2018 06; 151:30-36. PMID: 29729398.
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    22. Pasiliao CC, Hopyan S. Cell ingression: Relevance to limb development and for adaptive evolution. Genesis. 2018 01; 56(1). PMID: 29280270.
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    23. Gladstein AZ, Sachleben B, Ho ES, Anthony A, Clarke HM, Hopyan S. Forearm Pronation Osteotomy for Supination Contracture Secondary to Obstetrical Brachial Plexus Palsy: A Retrospective Cohort Study. J Pediatr Orthop. 2017 Sep; 37(6):e357-e363. PMID: 28719548.
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    24. Hopyan S. Biophysical regulation of early limb bud morphogenesis. Dev Biol. 2017 09 15; 429(2):429-433. PMID: 28669818.
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    25. Fenelon KD, Hopyan S. Structural components of nuclear integrity with gene regulatory potential. Curr Opin Cell Biol. 2017 10; 48:63-71. PMID: 28641117.
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    26. Wen J, Tao H, Lau K, Liu H, Simmons CA, Sun Y, Hopyan S. Cell and Tissue Scale Forces Coregulate Fgfr2-Dependent Tetrads and Rosettes in the Mouse Embryo. Biophys J. 2017 May 23; 112(10):2209-2218. PMID: 28538157.
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    27. Tao H, Kawakami Y, Hui CC, Hopyan S. The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies. Wiley Interdiscip Rev Dev Biol. 2017 07; 6(4). PMID: 28319333.
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    28. Deimling S, Sotiropoulos C, Lau K, Chaudhry S, Sturgeon K, Kelley S, Narayanan U, Howard A, Hui CC, Hopyan S. Tibial hemimelia associated with GLI3 truncation. J Hum Genet. 2016 May; 61(5):443-6. PMID: 26791356.
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    29. Stinson JN, Jibb LA, Nguyen C, Nathan PC, Maloney AM, Dupuis LL, Gerstle JT, Hopyan S, Alman BA, Strahlendorf C, Portwine C, Johnston DL. Construct validity and reliability of a real-time multidimensional smartphone app to assess pain in children and adolescents with cancer. Pain. 2015 Dec; 156(12):2607-2615. PMID: 26580680.
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    30. Lau K, Tao H, Liu H, Wen J, Sturgeon K, Sorfazlian N, Lazic S, Burrows JT, Wong MD, Li D, Deimling S, Ciruna B, Scott I, Simmons C, Henkelman RM, Williams T, Hadjantonakis AK, Fernandez-Gonzalez R, Sun Y, Hopyan S. Anisotropic stress orients remodelling of mammalian limb bud ectoderm. Nat Cell Biol. 2015 May; 17(5):569-79. PMID: 25893915.
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    31. Sainsbury DCG, Liu EH, Alvarez-Veronesi MC, Ho ES, Hopyan S, Zuker RM, Borschel GH. Long-term outcomes following lower extremity sarcoma resection and reconstruction with vascularized fibula flaps in children. Plast Reconstr Surg. 2014 Oct; 134(4):808-820. PMID: 24945953.
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    32. Kenawey M, Wright JG, Hopyan S, Murnaghan ML, Howard A, Kelley SP. Can neonatal pelvic osteotomies permanently change pelvic shape in patients with exstrophy? Understanding late rediastasis. J Bone Joint Surg Am. 2014 Aug 20; 96(16):e137. PMID: 25143505.
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    33. Li D, Sakuma R, Vakili NA, Mo R, Puviindran V, Deimling S, Zhang X, Hopyan S, Hui CC. Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling. Dev Cell. 2014 Apr 28; 29(2):233-40. PMID: 24726282.
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    34. Zhulyn O, Li D, Deimling S, Vakili NA, Mo R, Puviindran V, Chen MH, Chuang PT, Hopyan S, Hui CC. A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers. Dev Cell. 2014 Apr 28; 29(2):241-9. PMID: 24726283.
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    35. Ainsworth KE, Chavhan GB, Gupta AA, Hopyan S, Taylor G. Congenital infantile fibrosarcoma: review of imaging features. Pediatr Radiol. 2014 Sep; 44(9):1124-9. PMID: 24706181.
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    36. Liu H, Wen J, Xiao Y, Liu J, Hopyan S, Radisic M, Simmons CA, Sun Y. In situ mechanical characterization of the cell nucleus by atomic force microscopy. ACS Nano. 2014 Apr 22; 8(4):3821-8. PMID: 24673613.
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    37. Chaudhry S, Hopyan S. Bipolar latissimus transfer for restoration of elbow flexion. J Orthop. 2013; 10(3):133-8. PMID: 24396229.
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    38. Stinson JN, Jibb LA, Nguyen C, Nathan PC, Maloney AM, Dupuis LL, Gerstle JT, Alman B, Hopyan S, Strahlendorf C, Portwine C, Johnston DL, Orr M. Development and testing of a multidimensional iPhone pain assessment application for adolescents with cancer. J Med Internet Res. 2013 Mar 08; 15(3):e51. PMID: 23475457.
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    39. Dodwell E, O'Callaghan J, Anthony A, Jellicoe P, Shah M, Curtis C, Clarke H, Hopyan S. Combined glenoid anteversion osteotomy and tendon transfers for brachial plexus birth palsy: early outcomes. J Bone Joint Surg Am. 2012 Dec 05; 94(23):2145-52. PMID: 23224385.
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    40. Ibrahim T, Howard AW, Murnaghan ML, Hopyan S. Percutaneous curettage and suction for pediatric extremity aneurysmal bone cysts: is it adequate? J Pediatr Orthop. 2012 Dec; 32(8):842-7. PMID: 23147629.
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    41. Dodwell E, Hopyan S. Combined Glenoid Anteversion Osteotomy and Tendon Transfers for Brachial Plexus Birth Palsy. JBJS Essent Surg Tech. 2012 Oct; 2(4):e23. PMID: 31321143.
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    42. Jones KB, Ferguson PC, Lam B, Biau DJ, Hopyan S, Deheshi B, Griffin AM, White LM, Wunder JS. Effects of neoadjuvant chemotherapy on image-directed planning of surgical resection for distal femoral osteosarcoma. J Bone Joint Surg Am. 2012 Aug 01; 94(15):1399-405. PMID: 22854993.
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    43. Truong WH, Murnaghan ML, Hopyan S, Kelley SP. Ischioplasty for Femoroischial Impingement: A Case Report. JBJS Case Connect. 2012 Jul-Sep; 2(3):e51. PMID: 29252549.
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    44. Wyngaarden LA, Delgado-Olguin P, Su IH, Bruneau BG, Hopyan S. Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb. Development. 2011 Sep; 138(17):3759-67. PMID: 21795281.
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    45. Al-Hussaini H, Hogg D, Blackstein ME, O'Sullivan B, Catton CN, Chung PW, Griffin AM, Hodgson D, Hopyan S, Kandel R, Ferguson PC, Wunder JS, Gupta AA. Clinical features, treatment, and outcome in 102 adult and pediatric patients with localized high-grade synovial sarcoma. Sarcoma. 2011; 2011:231789. PMID: 21559258.
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    46. Hopyan S, Sharpe J, Yang Y. Budding behaviors: Growth of the limb as a model of morphogenesis. Dev Dyn. 2011 May; 240(5):1054-62. PMID: 21384474.
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    47. Canavese F, Wright JG, Cole WG, Hopyan S. Unicameral bone cysts: comparison of percutaneous curettage, steroid, and autologous bone marrow injections. J Pediatr Orthop. 2011 Jan-Feb; 31(1):50-5. PMID: 21150732.
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    48. Gupta AA, Pappo A, Saunders N, Hopyan S, Ferguson P, Wunder J, O'Sullivan B, Catton C, Greenberg M, Blackstein M. Clinical outcome of children and adults with localized Ewing sarcoma: impact of chemotherapy dose and timing of local therapy. Cancer. 2010 Jul 01; 116(13):3189-94. PMID: 20564643.
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    49. Wyngaarden LA, Vogeli KM, Ciruna BG, Wells M, Hadjantonakis AK, Hopyan S. Oriented cell motility and division underlie early limb bud morphogenesis. Development. 2010 Aug 01; 137(15):2551-8. PMID: 20554720.
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    50. Jellicoe P, Son-Hing J, Hopyan S, Thompson GH. Surgical hip dislocation for removal of intraarticular exostoses: report of two cases. J Pediatr Orthop. 2009 Jun; 29(4):327-30. PMID: 19461371.
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    51. Jellicoe P, Hopyan S. Can chronic recurrent multifocal osteomyelitis predispose to lymphoma of bone? A case report. J Pediatr Orthop B. 2008 Nov; 17(6):329-32. PMID: 18841069.
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    52. Wyngaarden LA, Hopyan S. Plasticity of proximal-distal cell fate in the mammalian limb bud. Dev Biol. 2008 Jan 01; 313(1):225-33. PMID: 18053979.
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    53. Mau E, Whetstone H, Yu C, Hopyan S, Wunder JS, Alman BA. PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms. Dev Biol. 2007 May 01; 305(1):28-39. PMID: 17328886.
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    54. Hopyan S, Tan JW, Graham HK, Torode IP. Function and upright time following limb salvage, amputation, and rotationplasty for pediatric sarcoma of bone. J Pediatr Orthop. 2006 May-Jun; 26(3):405-8. PMID: 16670557.
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    55. Tiet TD, Hopyan S, Nadesan P, Gokgoz N, Poon R, Lin AC, Yan T, Andrulis IL, Alman BA, Wunder JS. Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation. Am J Pathol. 2006 Jan; 168(1):321-30. PMID: 16400033.
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    56. Hopyan S, Nadesan P, Yu C, Wunder J, Alman BA. Dysregulation of hedgehog signalling predisposes to synovial chondromatosis. J Pathol. 2005 Jun; 206(2):143-50. PMID: 15834844.
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    57. Hopyan S, Ngan SY, Choong PF. Natural history of tumour-related sacral obliteration with nerve-root preservation. Clin Oncol (R Coll Radiol). 2005 May; 17(3):195-8. PMID: 15901005.
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    58. Hopyan S, Gokgoz N, Poon R, Gensure RC, Yu C, Cole WG, Bell RS, J├╝ppner H, Andrulis IL, Wunder JS, Alman BA. A mutant PTH/PTHrP type I receptor in enchondromatosis. Nat Genet. 2002 Mar; 30(3):306-10. PMID: 11850620.
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    59. Hopyan S, Gokgoz N, Bell RS, Andrulis IL, Alman BA, Wunder JS. Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours. J Orthop Res. 1999 Sep; 17(5):633-8. PMID: 10569470.
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    60. Bell RS, Hopyan S, Davis AM, Kandel R, Gross AE. Sarcoma of bone-cement membrane: a case report and review of the literature. Can J Surg. 1997 Feb; 40(1):51-5. PMID: 9030085.
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