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Brian Ciruna

TitleProgram Head & Senior Scientist
InstitutionThe Hospital for Sick Children
DepartmentDevelopmental & Stem Cell Biology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Konjikusic MJ, Yeetong P, Boswell CW, Lee C, Roberson EC, Ittiwut R, Suphapeetiporn K, Ciruna B, Gurnett CA, Wallingford JB, Shotelersuk V, Gray RS. Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development. PLoS Genet. 2018 Nov; 14(11):e1007817. PMID: 30475797.
      View in: PubMed
    2. Jussila M, Ciruna B. Zebrafish models of non-canonical Wnt/planar cell polarity signalling: fishing for valuable insight into vertebrate polarized cell behavior. Wiley Interdiscip Rev Dev Biol. 2017 05; 6(3). PMID: 28304136.
      View in: PubMed
    3. Boswell CW, Ciruna B. Understanding Idiopathic Scoliosis: A New Zebrafish School of Thought. Trends Genet. 2017 03; 33(3):183-196. PMID: 28174019.
      View in: PubMed
    4. Grimes DT, Boswell CW, Morante NF, Henkelman RM, Burdine RD, Ciruna B. Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature. Science. 2016 Jun 10; 352(6291):1341-4. PMID: 27284198.
      View in: PubMed
    5. Hanwell D, Hutchinson SA, Collymore C, Bruce AE, Louis R, Ghalami A, Allison WT, Ekker M, Eames BF, Childs S, Kurrasch DM, Gerlai R, Thiele T, Scott I, Ciruna B, Dowling JJ, McFarlane S, Huang P, Wen XY, Akimenko MA, Waskiewicz AJ, Drapeau P, Babiuk LA, Dragon D, Smida A, Buret AG, O'Grady E, Wilson J, Sowden-Plunkett L, Tropepe V. Restrictions on the Importation of Zebrafish into Canada Associated with Spring Viremia of Carp Virus. Zebrafish. 2016 07; 13 Suppl 1:S153-63. PMID: 27248438.
      View in: PubMed
    6. Lau K, Tao H, Liu H, Wen J, Sturgeon K, Sorfazlian N, Lazic S, Burrows JT, Wong MD, Li D, Deimling S, Ciruna B, Scott I, Simmons C, Henkelman RM, Williams T, Hadjantonakis AK, Fernandez-Gonzalez R, Sun Y, Hopyan S. Anisotropic stress orients remodelling of mammalian limb bud ectoderm. Nat Cell Biol. 2015 May; 17(5):569-79. PMID: 25893915; PMCID: PMC4955842.
    7. Carvajal-Gonzalez JM, Balmer S, Mendoza M, Dussert A, Collu G, Roman AC, Weber U, Ciruna B, Mlodzik M. The clathrin adaptor AP-1 complex and Arf1 regulate planar cell polarity in vivo. Nat Commun. 2015 Apr 07; 6:6751. PMID: 25849195; PMCID: PMC4515971.
    8. Hayes M, Gao X, Yu LX, Paria N, Henkelman RM, Wise CA, Ciruna B. ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease. Nat Commun. 2014 Sep 03; 5:4777. PMID: 25182715; PMCID: PMC4155517.
    9. Superina S, Borovina A, Ciruna B. Analysis of maternal-zygotic ugdh mutants reveals divergent roles for HSPGs in vertebrate embryogenesis and provides new insight into the initiation of left-right asymmetry. Dev Biol. 2014 Mar 15; 387(2):154-66. PMID: 24462977.
      View in: PubMed
    10. Borovina A, Ciruna B. IFT88 plays a cilia- and PCP-independent role in controlling oriented cell divisions during vertebrate embryonic development. Cell Rep. 2013 Oct 17; 5(1):37-43. PMID: 24095732.
      View in: PubMed
    11. Pan YA, Freundlich T, Weissman TA, Schoppik D, Wang XC, Zimmerman S, Ciruna B, Sanes JR, Lichtman JW, Schier AF. Zebrabow: multispectral cell labeling for cell tracing and lineage analysis in zebrafish. Development. 2013 Jul; 140(13):2835-46. PMID: 23757414; PMCID: PMC3678346.
    12. Hayes M, Naito M, Daulat A, Angers S, Ciruna B. Ptk7 promotes non-canonical Wnt/PCP-mediated morphogenesis and inhibits Wnt/ß-catenin-dependent cell fate decisions during vertebrate development. Development. 2013 Apr; 140(8):1807-18. PMID: 23533179.
      View in: PubMed
    13. Schoenebeck JJ, Hutchinson SA, Byers A, Beale HC, Carrington B, Faden DL, Rimbault M, Decker B, Kidd JM, Sood R, Boyko AR, Fondon JW, Wayne RK, Bustamante CD, Ciruna B, Ostrander EA. Variation of BMP3 contributes to dog breed skull diversity. PLoS Genet. 2012; 8(8):e1002849. PMID: 22876193; PMCID: PMC3410846.
    14. Persaud A, Alberts P, Hayes M, Guettler S, Clarke I, Sicheri F, Dirks P, Ciruna B, Rotin D. Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. EMBO J. 2011 Jul 15; 30(16):3259-73. PMID: 21765395; PMCID: PMC3160656.
    15. Miyamoto T, Porazinski S, Wang H, Borovina A, Ciruna B, Shimizu A, Kajii T, Kikuchi A, Furutani-Seiki M, Matsuura S. Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates. Hum Mol Genet. 2011 May 15; 20(10):2058-70. PMID: 21389084.
      View in: PubMed
    16. Wyngaarden LA, Vogeli KM, Ciruna BG, Wells M, Hadjantonakis AK, Hopyan S. Oriented cell motility and division underlie early limb bud morphogenesis. Development. 2010 Aug 01; 137(15):2551-8. PMID: 20554720; PMCID: PMC2927701.
    17. Borovina A, Superina S, Voskas D, Ciruna B. Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia. Nat Cell Biol. 2010 Apr; 12(4):407-12. PMID: 20305649.
      View in: PubMed
    18. Calarco JA, Superina S, O'Hanlon D, Gabut M, Raj B, Pan Q, Skalska U, Clarke L, Gelinas D, van der Kooy D, Zhen M, Ciruna B, Blencowe BJ. Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein. Cell. 2009 Sep 04; 138(5):898-910. PMID: 19737518.
      View in: PubMed
    19. Yin C, Ciruna B, Solnica-Krezel L. Convergence and extension movements during vertebrate gastrulation. Curr Top Dev Biol. 2009; 89:163-92. PMID: 19737646.
      View in: PubMed
    20. Voskas D, Babichev Y, Ling LS, Alami J, Shaked Y, Kerbel RS, Ciruna B, Dumont DJ. An eosinophil immune response characterizes the inflammatory skin disease observed in Tie-2 transgenic mice. J Leukoc Biol. 2008 Jul; 84(1):59-67. PMID: 18443190; PMCID: PMC3178502.
    21. Bennett JT, Stickney HL, Choi WY, Ciruna B, Talbot WS, Schier AF. Maternal nodal and zebrafish embryogenesis. Nature. 2007 Nov 08; 450(7167):E1-2; discussion E2-4. PMID: 17994032.
      View in: PubMed
    22. Wang W, Liu X, Gelinas D, Ciruna B, Sun Y. A fully automated robotic system for microinjection of zebrafish embryos. PLoS One. 2007 Sep 12; 2(9):e862. PMID: 17848993.
      View in: PubMed
    23. Ciruna B, Jenny A, Lee D, Mlodzik M, Schier AF. Planar cell polarity signalling couples cell division and morphogenesis during neurulation. Nature. 2006 Jan 12; 439(7073):220-4. PMID: 16407953; PMCID: PMC1417047.
    24. Zhao H, Yang Y, Partanen J, Ciruna BG, Rossant J, Robinson ML. Fibroblast growth factor receptor 1 (Fgfr1) is not essential for lens fiber differentiation in mice. Mol Vis. 2006 Jan 10; 12:15-25. PMID: 16446698; PMCID: PMC4280232.
    25. Ciruna B, Weidinger G, Knaut H, Thisse B, Thisse C, Raz E, Schier AF. Production of maternal-zygotic mutant zebrafish by germ-line replacement. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):14919-24. PMID: 12397179; PMCID: PMC137520.
    26. Ciruna B, Rossant J. FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev Cell. 2001 Jul; 1(1):37-49. PMID: 11703922.
      View in: PubMed
    27. Saxton TM, Ciruna BG, Holmyard D, Kulkarni S, Harpal K, Rossant J, Pawson T. The SH2 tyrosine phosphatase shp2 is required for mammalian limb development. Nat Genet. 2000 Apr; 24(4):420-3. PMID: 10742110.
      View in: PubMed
    28. Tropepe V, Sibilia M, Ciruna BG, Rossant J, Wagner EF, van der Kooy D. Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon. Dev Biol. 1999 Apr 01; 208(1):166-88. PMID: 10075850.
      View in: PubMed
    29. Ciruna BG, Rossant J. Expression of the T-box gene Eomesodermin during early mouse development. Mech Dev. 1999 Mar; 81(1-2):199-203. PMID: 10330500.
      View in: PubMed
    30. Ciruna BG, Schwartz L, Harpal K, Yamaguchi TP, Rossant J. Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak. Development. 1997 Jul; 124(14):2829-41. PMID: 9226454.
      View in: PubMed
    31. Rossant J, Ciruna B, Partanen J. FGF signaling in mouse gastrulation and anteroposterior patterning. Cold Spring Harb Symp Quant Biol. 1997; 62:127-33. PMID: 9598344.
      View in: PubMed
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