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Sean Egan

TitleSenior Scientist
InstitutionThe Hospital for Sick Children
DepartmentCell Biology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. An Y, Adams JR, Hollern DP, Zhao A, Chang SG, Gams MS, Chung PED, He X, Jangra R, Shah JS, Yang J, Beck LA, Raghuram N, Kozma KJ, Loch AJ, Wang W, Fan C, Done SJ, Zacksenhaus E, Guidos CJ, Perou CM, Egan SE. Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast. Cell Rep. 2018 Oct 16; 25(3):702-714.e6. PMID: 30332649.
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    2. Liu JC, Granieri L, Shrestha M, Wang DY, Vorobieva I, Rubie EA, Jones R, Ju Y, Pellecchia G, Jiang Z, Palmerini CA, Ben-David Y, Egan SE, Woodgett JR, Bader GD, Datti A, Zacksenhaus E. Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer. Cell Rep. 2018 Apr 03; 23(1):112-126. PMID: 29617654.
      View in: PubMed
    3. Fernandes DJ, Ellegood J, Askalan R, Blakely RD, Dicicco-Bloom E, Egan SE, Osborne LR, Powell CM, Raznahan A, Robins DM, Salter MW, Sengar AS, Veenstra-VanderWeele J, Henkelman RM, Lerch JP. Spatial gene expression analysis of neuroanatomical differences in mouse models. Neuroimage. 2017 12; 163:220-230. PMID: 28882630.
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    4. Hammoud L, Adams JR, Loch AJ, Marcellus RC, Uehling DE, Aman A, Fladd C, McKee TD, Jo CEB, Al-Awar R, Egan SE, Rossant J. Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay. Stem Cell Reports. 2016 10 11; 7(4):787-801. PMID: 27618721.
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    5. Jones RA, Robinson TJ, Liu JC, Shrestha M, Voisin V, Ju Y, Chung PE, Pellecchia G, Fell VL, Bae S, Muthuswamy L, Datti A, Egan SE, Jiang Z, Leone G, Bader GD, Schimmer A, Zacksenhaus E. RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation. J Clin Invest. 2016 10 03; 126(10):3739-3757. PMID: 27571409.
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    6. Liu JC, Wang DY, Egan SE, Zacksenhaus E. Common and distinct features of mammary tumors driven by Pten-deletion or activating Pik3ca mutation. Oncotarget. 2016 Feb 23; 7(8):9060-8. PMID: 26814435; PMCID: PMC4891026.
    7. Wright KL, Adams JR, Liu JC, Loch AJ, Wong RG, Jo CE, Beck LA, Santhanam DR, Weiss L, Mei X, Lane TF, Koralov SB, Done SJ, Woodgett JR, Zacksenhaus E, Hu P, Egan SE. Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer Patients. Cancer Res. 2015 Nov 15; 75(22):4960-72. PMID: 26400062.
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    8. Zhang S, Chung WC, Wu G, Egan SE, Miele L, Xu K. Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction. Cancer Res. 2015 May 15; 75(10):1936-43. PMID: 25808869; PMCID: PMC4433600.
    9. Jiang K, Wright KL, Zhu P, Szego MJ, Bramall AN, Hauswirth WW, Li Q, Egan SE, McInnes RR. STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration models. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):E5716-23. PMID: 25512545; PMCID: PMC4284576.
    10. Liu JC, Voisin V, Wang S, Wang DY, Jones RA, Datti A, Uehling D, Al-awar R, Egan SE, Bader GD, Tsao M, Mak TW, Zacksenhaus E. Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. EMBO Mol Med. 2014 Dec; 6(12):1542-60. PMID: 25330770; PMCID: PMC4287974.
    11. Xu K, Bägli DJ, Egan SE. NOTch just a bladder control problem. Cancer Cell. 2014 Oct 13; 26(4):452-4. PMID: 25314075.
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    12. Wu AM, Yang M, Dalvi P, Turinsky AL, Wang W, Butcher D, Egan SE, Weksberg R, Harper PA, Ito S. Role of STAT5 and epigenetics in lactation-associated upregulation of multidrug transporter ABCG2 in the mammary gland. Am J Physiol Endocrinol Metab. 2014 Oct 01; 307(7):E596-610. PMID: 25117410.
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    13. Jiang Z, Liu JC, Chung PE, Egan SE, Zacksenhaus E. Targeting HER2(+) breast cancer: the TBK1/IKKe axis. Oncoscience. 2014; 1(2):180-2. PMID: 25594009; PMCID: PMC4278282.
    14. Zhang S, Chung WC, Wu G, Egan SE, Xu K. Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation. Neoplasia. 2014 Feb; 16(2):158-67. PMID: 24709423; PMCID: PMC3978396.
    15. Deng T, Liu JC, Chung PE, Uehling D, Aman A, Joseph B, Ketela T, Jiang Z, Schachter NF, Rottapel R, Egan SE, Al-Awar R, Moffat J, Zacksenhaus E. shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer. Cancer Res. 2014 Apr 01; 74(7):2119-30. PMID: 24487029.
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    16. Pfefferle AD, Herschkowitz JI, Usary J, Harrell JC, Spike BT, Adams JR, Torres-Arzayus MI, Brown M, Egan SE, Wahl GM, Rosen JM, Perou CM. Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol. 2013 Nov 12; 14(11):R125. PMID: 24220145; PMCID: PMC4053990.
    17. Robinson TJ, Liu JC, Vizeacoumar F, Sun T, Maclean N, Egan SE, Schimmer AD, Datti A, Zacksenhaus E. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS One. 2013; 8(11):e78641. PMID: 24265703; PMCID: PMC3827056.
    18. Robinson TJ, Pai M, Liu JC, Vizeacoumar F, Sun T, Egan SE, Datti A, Huang J, Zacksenhaus E. High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: interaction with IQ motif-containing factors. Cell Cycle. 2013 Sep 15; 12(18):3013-24. PMID: 23974104; PMCID: PMC3875676.
    19. Liu JC, Egan SE, Zacksenhaus E. A Tumor initiating cell-enriched prognostic signature for HER2+:ERa- breast cancer; rationale, new features, controversies and future directions. Oncotarget. 2013 Aug; 4(8):1317-28. PMID: 23945331; PMCID: PMC3787160.
    20. Sargin D, Botly LC, Higgs G, Marsolais A, Frankland PW, Egan SE, Josselyn SA. Reprint of: disrupting Jagged1-Notch signaling impairs spatial memory formation in adult mice. Neurobiol Learn Mem. 2013 Oct; 105:20-30. PMID: 23850596.
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    21. Zhang S, Loch AJ, Radtke F, Egan SE, Xu K. Jagged1 is the major regulator of Notch-dependent cell fate in proximal airways. Dev Dyn. 2013 Jun; 242(6):678-86. PMID: 23526493.
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    22. Sargin D, Botly LC, Higgs G, Marsolais A, Frankland PW, Egan SE, Josselyn SA. Disrupting Jagged1-Notch signaling impairs spatial memory formation in adult mice. Neurobiol Learn Mem. 2013 Jul; 103:39-49. PMID: 23567106.
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    23. Sengar AS, Ellegood J, Yiu AP, Wang H, Wang W, Juneja SC, Lerch JP, Josselyn SA, Henkelman RM, Salter MW, Egan SE. Vertebrate intersectin1 is repurposed to facilitate cortical midline connectivity and higher order cognition. J Neurosci. 2013 Feb 27; 33(9):4055-65. PMID: 23447614.
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    24. Xu K, Usary J, Kousis PC, Prat A, Wang DY, Adams JR, Wang W, Loch AJ, Deng T, Zhao W, Cardiff RD, Yoon K, Gaiano N, Ling V, Beyene J, Zacksenhaus E, Gridley T, Leong WL, Guidos CJ, Perou CM, Egan SE. Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer. Cancer Cell. 2012 May 15; 21(5):626-41. PMID: 22624713; PMCID: PMC3603366.
    25. Liu JC, Voisin V, Bader GD, Deng T, Pusztai L, Symmans WF, Esteva FJ, Egan SE, Zacksenhaus E. Seventeen-gene signature from enriched Her2/Neu mammary tumor-initiating cells predicts clinical outcome for human HER2+:ERa- breast cancer. Proc Natl Acad Sci U S A. 2012 Apr 10; 109(15):5832-7. PMID: 22460789.
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    26. Li Y, Vecchiarelli-Federico LM, Li YJ, Egan SE, Spaner D, Hough MR, Ben-David Y. The miR-17-92 cluster expands multipotent hematopoietic progenitors whereas imbalanced expression of its individual oncogenic miRNAs promotes leukemia in mice. Blood. 2012 May 10; 119(19):4486-98. PMID: 22451425.
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    27. Xu K, Moghal N, Egan SE. Notch signaling in lung development and disease. Adv Exp Med Biol. 2012; 727:89-98. PMID: 22399341.
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    28. Waters AM, Wu MY, Huang YW, Liu GY, Holmyard D, Onay T, Jones N, Egan SE, Robinson LA, Piscione TD. Notch promotes dynamin-dependent endocytosis of nephrin. J Am Soc Nephrol. 2012 Jan; 23(1):27-35. PMID: 22052054; PMCID: PMC3269920.
    29. Suliman S, Tan J, Xu K, Kousis PC, Kowalski PE, Chang G, Egan SE, Guidos C. Notch3 is dispensable for thymocyte ß-selection and Notch1-induced T cell leukemogenesis. PLoS One. 2011; 6(9):e24937. PMID: 21931869; PMCID: PMC3172312.
    30. Raafat A, Goldhar AS, Klauzinska M, Xu K, Amirjazil I, McCurdy D, Lashin K, Salomon D, Vonderhaar BK, Egan S, Callahan R. Expression of Notch receptors, ligands, and target genes during development of the mouse mammary gland. J Cell Physiol. 2011 Jul; 226(7):1940-52. PMID: 21506125.
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    31. Adams JR, Schachter NF, Liu JC, Zacksenhaus E, Egan SE. Elevated PI3K signaling drives multiple breast cancer subtypes. Oncotarget. 2011 Jun; 2(6):435-47. PMID: 21646685; PMCID: PMC3248195.
    32. Jiang Z, Jones R, Liu JC, Deng T, Robinson T, Chung PE, Wang S, Herschkowitz JI, Egan SE, Perou CM, Zacksenhaus E. RB1 and p53 at the crossroad of EMT and triple-negative breast cancer. Cell Cycle. 2011 May 15; 10(10):1563-70. PMID: 21502814.
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    33. Adams JR, Xu K, Liu JC, Agamez NM, Loch AJ, Wong RG, Wang W, Wright KL, Lane TF, Zacksenhaus E, Egan SE. Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation. Cancer Res. 2011 Apr 01; 71(7):2706-17. PMID: 21324922.
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    34. Yuan JS, Tan JB, Visan I, Matei IR, Urbanellis P, Xu K, Danska JS, Egan SE, Guidos CJ. Lunatic Fringe prolongs Delta/Notch-induced self-renewal of committed aß T-cell progenitors. Blood. 2011 Jan 27; 117(4):1184-95. PMID: 21097675.
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    35. Taylor A, Wang D, Patel K, Whittall R, Wood G, Farrer M, Neely RD, Fairgrieve S, Nair D, Barbir M, Jones JL, Egan S, Everdale R, Lolin Y, Hughes E, Cooper JA, Hadfield SG, Norbury G, Humphries SE. Mutation detection rate and spectrum in familial hypercholesterolaemia patients in the UK pilot cascade project. Clin Genet. 2010 Jun; 77(6):572-80. PMID: 20236128.
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    36. Xu K, Nieuwenhuis E, Cohen BL, Wang W, Canty AJ, Danska JS, Coultas L, Rossant J, Wu MY, Piscione TD, Nagy A, Gossler A, Hicks GG, Hui CC, Henkelman RM, Yu LX, Sled JG, Gridley T, Egan SE. Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis. Am J Physiol Lung Cell Mol Physiol. 2010 Jan; 298(1):L45-56. PMID: 19897741; PMCID: PMC2806195.
    37. Tan JB, Xu K, Cretegny K, Visan I, Yuan JS, Egan SE, Guidos CJ. Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches. Immunity. 2009 Feb 20; 30(2):254-63. PMID: 19217325.
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    38. Reedijk M, Odorcic S, Zhang H, Chetty R, Tennert C, Dickson BC, Lockwood G, Gallinger S, Egan SE. Activation of Notch signaling in human colon adenocarcinoma. Int J Oncol. 2008 Dec; 33(6):1223-9. PMID: 19020755; PMCID: PMC2739737.
    39. Bane AL, Pinnaduwage D, Colby S, Reedijk M, Egan SE, Bull SB, O'Malley FP, Andrulis IL. Expression profiling of familial breast cancers demonstrates higher expression of FGFR2 in BRCA2-associated tumors. Breast Cancer Res Treat. 2009 Sep; 117(1):183-91. PMID: 18563556; PMCID: PMC2727582.
    40. Wang W, Bouhours M, Gracheva EO, Liao EH, Xu K, Sengar AS, Xin X, Roder J, Boone C, Richmond JE, Zhen M, Egan SE. ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Traffic. 2008 May; 9(5):742-54. PMID: 18298590; PMCID: PMC3791081.
    41. Jiang X, Tian F, Du Y, Copeland NG, Jenkins NA, Tessarollo L, Wu X, Pan H, Hu XZ, Xu K, Kenney H, Egan SE, Turley H, Harris AL, Marini AM, Lipsky RH. BHLHB2 controls Bdnf promoter 4 activity and neuronal excitability. J Neurosci. 2008 Jan 30; 28(5):1118-30. PMID: 18234890.
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    42. Reedijk M, Pinnaduwage D, Dickson BC, Mulligan AM, Zhang H, Bull SB, O'Malley FP, Egan SE, Andrulis IL. JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer. Breast Cancer Res Treat. 2008 Oct; 111(3):439-48. PMID: 17990101.
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    43. Dickson BC, Mulligan AM, Zhang H, Lockwood G, O'Malley FP, Egan SE, Reedijk M. High-level JAG1 mRNA and protein predict poor outcome in breast cancer. Mod Pathol. 2007 Jun; 20(6):685-93. PMID: 17507991.
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    44. Baliko F, Bright T, Poon R, Cohen B, Egan SE, Alman BA. Inhibition of notch signaling induces neural differentiation in Ewing sarcoma. Am J Pathol. 2007 May; 170(5):1686-94. PMID: 17456774; PMCID: PMC1854963.
    45. Reedijk M, Odorcic S, Chang L, Zhang H, Miller N, McCready DR, Lockwood G, Egan SE. High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res. 2005 Sep 15; 65(18):8530-7. PMID: 16166334.
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    46. St-Pierre B, Jiang Z, Egan SE, Zacksenhaus E. High expression during neurogenesis but not mammogenesis of a murine homologue of the Deleted in Breast Cancer2/Rhobtb2 tumor suppressor. Gene Expr Patterns. 2004 Dec; 5(2):245-51. PMID: 15567721.
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    47. Hughes M, Dobric N, Scott IC, Su L, Starovic M, St-Pierre B, Egan SE, Kingdom JC, Cross JC. The Hand1, Stra13 and Gcm1 transcription factors override FGF signaling to promote terminal differentiation of trophoblast stem cells. Dev Biol. 2004 Jul 01; 271(1):26-37. PMID: 15196947.
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    48. St-Pierre B, Cooper M, Jiang Z, Zacksenhaus E, Egan SE. Dynamic regulation of the Stra13/Sharp/Dec bHLH repressors in mammary epithelium. Dev Dyn. 2004 May; 230(1):124-30. PMID: 15108316.
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    49. Callahan R, Egan SE. Notch signaling in mammary development and oncogenesis. J Mammary Gland Biol Neoplasia. 2004 Apr; 9(2):145-63. PMID: 15300010.
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    50. St-Pierre B, Flock G, Zacksenhaus E, Egan SE. Stra13 homodimers repress transcription through class B E-box elements. J Biol Chem. 2002 Nov 29; 277(48):46544-51. PMID: 12297495.
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    51. Koch U, Lacombe TA, Holland D, Bowman JL, Cohen BL, Egan SE, Guidos CJ. Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1. Immunity. 2001 Aug; 15(2):225-36. PMID: 11520458.
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    52. Egan S, Cohen B, Sarkar M, Ying Y, Cohen S, Singh N, Wang W, Flock G, Goh T, Schachter H. Molecular cloning and expression analysis of a mouse UDP-GlcNAc:Gal(beta1-4)Glc(NAc)-R beta1,3-N-acetylglucosaminyltransferase homologous to Drosophila melanogaster Brainiac and the beta1,3-galactosyltransferase family. Glycoconj J. 2000 Dec; 17(12):867-75. PMID: 11511811.
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    53. Singh N, Phillips RA, Iscove NN, Egan SE. Expression of notch receptors, notch ligands, and fringe genes in hematopoiesis. Exp Hematol. 2000 May; 28(5):527-34. PMID: 10812242.
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    54. Sengar AS, Wang W, Bishay J, Cohen S, Egan SE. The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15. EMBO J. 1999 Mar 01; 18(5):1159-71. PMID: 10064583; PMCID: PMC1171207.
    55. Egan S, Herbrick JA, Tsui LC, Cohen B, Flock G, Beatty B, Scherer SW. Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12. Genomics. 1998 Dec 15; 54(3):576-7. PMID: 9878264.
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    56. McPherson PS, de Heuvel E, Phillie J, Wang W, Sengar A, Egan S. EH domain-dependent interactions between Eps15 and clathrin-coated vesicle protein p95. Biochem Biophys Res Commun. 1998 Mar 27; 244(3):701-5. PMID: 9535728.
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    57. Egan SE, St-Pierre B, Leow CC. Notch receptors, partners and regulators: from conserved domains to powerful functions. Curr Top Microbiol Immunol. 1998; 228:273-324. PMID: 9401210.
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    58. Cohen B, Bashirullah A, Dagnino L, Campbell C, Fisher WW, Leow CC, Whiting E, Ryan D, Zinyk D, Boulianne G, Hui CC, Gallie B, Phillips RA, Lipshitz HD, Egan SE. Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila. Nat Genet. 1997 Jul; 16(3):283-8. PMID: 9207795.
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    59. Egan SE, McInnes RR. Human genetics. Blindness and the X. Nature. 1996 May 16; 381(6579):194-5. PMID: 8622755.
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    60. Hack N, Tay A, Schultz A, Muzin N, Clayman P, Egan S, Skorecki KL. Regulation of rat kidney mesangial cell phospholipase A2. Clin Exp Pharmacol Physiol. 1996 Jan; 23(1):71-5. PMID: 8713499.
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    61. Wang W, Fisher EM, Jia Q, Dunn JM, Porfiri E, Downward J, Egan SE. The Grb2 binding domain of mSos1 is not required for downstream signal transduction. Nat Genet. 1995 Jul; 10(3):294-300. PMID: 7670467.
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    62. Egan SE, Giddings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature. 1993 May 06; 363(6424):45-51. PMID: 8479536.
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    63. Taylor WR, Egan SE, Mowat M, Greenberg AH, Wright JA. Evidence for synergistic interactions between ras, myc and a mutant form of p53 in cellular transformation and tumor dissemination. Oncogene. 1992 Jul; 7(7):1383-90. PMID: 1620551.
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    64. Conway T, Fliege R, Jones-Kilpatrick D, Liu J, Barnell WO, Egan SE. Cloning, characterization and expression of the Zymononas mobilis eda gene that encodes 2-keto-3-deoxy-6-phosphogluconate aldolase of the Entner-Doudoroff pathway. Mol Microbiol. 1991 Dec; 5(12):2901-11. PMID: 1809834.
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    65. Egan SE, Wright JA, Greenberg AH. Molecular determinants of metastatic transformation. Environ Health Perspect. 1991 Jun; 93:91-5. PMID: 1773806.
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    66. Hicks GG, Egan SE, Greenberg AH, Mowat M. Mutant p53 tumor suppressor alleles release ras-induced cell cycle growth arrest. Mol Cell Biol. 1991 Mar; 11(3):1344-52. PMID: 1996096; PMCID: PMC369405.
    67. Greenberg AH, Egan SE, Jarolim L, Wright JA. NK sensitivity of H-ras transfected fibroblasts is transformation- independent. Cell Immunol. 1987 Oct 15; 109(2):444-50. PMID: 3311387.
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    68. Greenberg AH, Egan SE, Jarolim L, Gingras MC, Wright JA. Natural killer cell regulation of implantation and early lung growth of H-ras-transformed 10T1/2 fibroblasts in mice. Cancer Res. 1987 Sep 15; 47(18):4801-5. PMID: 3621176.
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    69. Denhardt DT, Greenberg AH, Egan SE, Hamilton RT, Wright JA. Cysteine proteinase cathepsin L expression correlates closely with the metastatic potential of H-ras-transformed murine fibroblasts. Oncogene. 1987; 2(1):55-9. PMID: 3438085.
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