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Colin McKerlie

TitleSenior Associate Scientist
InstitutionThe Hospital for Sick Children
DepartmentTranslational Medicine
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Moore BA, Leonard BC, Sebbag L, Edwards SG, Cooper A, Imai DM, Straiton E, Santos L, Reilly C, Griffey SM, Bower L, Clary D, Mason J, Roux MJ, Meziane H, Herault Y, McKerlie C, Flenniken AM, Nutter LMJ, Berberovic Z, Owen C, Newbigging S, Adissu H, Eskandarian M, Hsu CW, Kalaga S, Udensi U, Asomugha C, Bohat R, Gallegos JJ, Seavitt JR, Heaney JD, Beaudet AL, Dickinson ME, Justice MJ, Philip V, Kumar V, Svenson KL, Braun RE, Wells S, Cater H, Stewart M, Clementson-Mobbs S, Joynson R, Gao X, Suzuki T, Wakana S, Smedley D, Seong JK, Tocchini-Valentini G, Moore M, Fletcher C, Karp N, Ramirez-Solis R, White JK, de Angelis MH, Wurst W, Thomasy SM, Flicek P, Parkinson H, Brown SDM, Meehan TF, Nishina PM, Murray SA, Krebs MP, Mallon AM, Lloyd KCK, Murphy CJ, Moshiri A. Identification of genes required for eye development by high-throughput screening of mouse knockouts. Commun Biol. 2018; 1:236. PMID: 30588515.
      View in: PubMed
    2. Elmore SA, Cardiff R, Cesta MF, Gkoutos GV, Hoehndorf R, Keenan CM, McKerlie C, Schofield PN, Sundberg JP, Ward JM. A Review of Current Standards and the Evolution of Histopathology Nomenclature for Laboratory Animals. ILAR J. 2018 Nov 22. PMID: 30476141.
      View in: PubMed
    3. Yildiz C, Mullen B, Jarvi K, McKerlie C, Lo KC. Comparison of cryosurvival and spermatogenesis efficiency of cryopreserved neonatal mouse testicular tissue between three vitrification protocols and controlled-rate freezing. Cryobiology. 2018 Oct; 84:4-9. PMID: 30195700.
      View in: PubMed
    4. Muñoz-Fuentes V, Cacheiro P, Meehan TF, Aguilar-Pimentel JA, Brown SDM, Flenniken AM, Flicek P, Galli A, Mashhadi HH, Hrabe de Angelis M, Kim JK, Lloyd KCK, McKerlie C, Morgan H, Murray SA, Nutter LMJ, Reilly PT, Seavitt JR, Seong JK, Simon M, Wardle-Jones H, Mallon AM, Smedley D, Parkinson HE. The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservation. Conserv Genet. 2018; 19(4):995-1005. PMID: 30100824.
      View in: PubMed
    5. Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie Helmut Fuchs SM, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Nutter SNLMJ, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, Wurst W, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SDM, Adams DJ, Lloyd KCK, McKerlie C, Beaudet AL, Murray MBSA. Corrigendum: High-throughput discovery of novel developmental phenotypes. Nature. 2017 11 16; 551(7680):398. PMID: 29144450.
      View in: PubMed
    6. Bowl MR, Simon MM, Ingham NJ, Greenaway S, Santos L, Cater H, Taylor S, Mason J, Kurbatova N, Pearson S, Bower LR, Clary DA, Meziane H, Reilly P, Minowa O, Kelsey L, Tocchini-Valentini GP, Gao X, Bradley A, Skarnes WC, Moore M, Beaudet AL, Justice MJ, Seavitt J, Dickinson ME, Wurst W, de Angelis MH, Herault Y, Wakana S, Nutter LMJ, Flenniken AM, McKerlie C, Murray SA, Svenson KL, Braun RE, West DB, Lloyd KCK, Adams DJ, White J, Karp N, Flicek P, Smedley D, Meehan TF, Parkinson HE, Teboul LM, Wells S, Steel KP, Mallon AM, Brown SDM. A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction. Nat Commun. 2017 10 12; 8(1):886. PMID: 29026089.
      View in: PubMed
    7. Meehan TF, Conte N, West DB, Jacobsen JO, Mason J, Warren J, Chen CK, Tudose I, Relac M, Matthews P, Karp N, Santos L, Fiegel T, Ring N, Westerberg H, Greenaway S, Sneddon D, Morgan H, Codner GF, Stewart ME, Brown J, Horner N, Haendel M, Washington N, Mungall CJ, Reynolds CL, Gallegos J, Gailus-Durner V, Sorg T, Pavlovic G, Bower LR, Moore M, Morse I, Gao X, Tocchini-Valentini GP, Obata Y, Cho SY, Seong JK, Seavitt J, Beaudet AL, Dickinson ME, Herault Y, Wurst W, de Angelis MH, Lloyd KCK, Flenniken AM, Nutter LMJ, Newbigging S, McKerlie C, Justice MJ, Murray SA, Svenson KL, Braun RE, White JK, Bradley A, Flicek P, Wells S, Skarnes WC, Adams DJ, Parkinson H, Mallon AM, Brown SDM, Smedley D. Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. Nat Genet. 2017 Aug; 49(8):1231-1238. PMID: 28650483.
      View in: PubMed
    8. Karp NA, Mason J, Beaudet AL, Benjamini Y, Bower L, Braun RE, Brown SDM, Chesler EJ, Dickinson ME, Flenniken AM, Fuchs H, Angelis MH, Gao X, Guo S, Greenaway S, Heller R, Herault Y, Justice MJ, Kurbatova N, Lelliott CJ, Lloyd KCK, Mallon AM, Mank JE, Masuya H, McKerlie C, Meehan TF, Mott RF, Murray SA, Parkinson H, Ramirez-Solis R, Santos L, Seavitt JR, Smedley D, Sorg T, Speak AO, Steel KP, Svenson KL, Wakana S, West D, Wells S, Westerberg H, Yaacoby S, White JK. Prevalence of sexual dimorphism in mammalian phenotypic traits. Nat Commun. 2017 06 26; 8:15475. PMID: 28650954.
      View in: PubMed
    9. Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M, Murray SA. High-throughput discovery of novel developmental phenotypes. Nature. 2016 09 22; 537(7621):508-514. PMID: 27626380.
      View in: PubMed
    10. Lloyd KC, McKerlie C, Seong JK, Neff F. Comment on "One health, one literature: Weaving together veterinary and medical research". Sci Transl Med. 2015 Dec 09; 7(317):317le3. PMID: 26659567.
      View in: PubMed
    11. Katsifa A, Kaffe E, Nikolaidou-Katsaridou N, Economides AN, Newbigging S, McKerlie C, Aidinis V. The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life. PLoS One. 2015; 10(11):e0143083. PMID: 26569406; PMCID: PMC4646642.
      View in: PubMed, PubMed Central
    12. Adissu HA, McKerlie C, Di Grappa M, Waterhouse P, Xu Q, Fang H, Khokha R, Wood GA. Timp3 loss accelerates tumour invasion and increases prostate inflammation in a mouse model of prostate cancer. Prostate. 2015 Dec; 75(16):1831-43. PMID: 26332574.
      View in: PubMed
    13. de Angelis MH, Nicholson G, Selloum M, White J, Morgan H, Ramirez-Solis R, Sorg T, Wells S, Fuchs H, Fray M, Adams DJ, Adams NC, Adler T, Aguilar-Pimentel A, Ali-Hadji D, Amann G, André P, Atkins S, Auburtin A, Ayadi A, Becker J, Becker L, Bedu E, Bekeredjian R, Birling MC, Blake A, Bottomley J, Bowl M, Brault V, Busch DH, Bussell JN, Calzada-Wack J, Cater H, Champy MF, Charles P, Chevalier C, Chiani F, Codner GF, Combe R, Cox R, Dalloneau E, Dierich A, Di Fenza A, Doe B, Duchon A, Eickelberg O, Esapa CT, El Fertak L, Feigel T, Emelyanova I, Estabel J, Favor J, Flenniken A, Gambadoro A, Garrett L, Gates H, Gerdin AK, Gkoutos G, Greenaway S, Glasl L, Goetz P, Da Cruz IG, Götz A, Graw J, Guimond A, Hans W, Hicks G, Hölter SM, Höfler H, Hancock JM, Hoehndorf R, Hough T, Houghton R, Hurt A, Ivandic B, Jacobs H, Jacquot S, Jones N, Karp NA, Katus HA, Kitchen S, Klein-Rodewald T, Klingenspor M, Klopstock T, Lalanne V, Leblanc S, Lengger C, le Marchand E, Ludwig T, Lux A, McKerlie C, Maier H, Mandel JL, Marschall S, Mark M, Melvin DG, Meziane H, Micklich K, Mittelhauser C, Monassier L, Moulaert D, Muller S, Naton B, Neff F, Nolan PM, Nutter LM, Ollert M, Pavlovic G, Pellegata NS, Peter E, Petit-Demoulière B, Pickard A, Podrini C, Potter P, Pouilly L, Puk O, Richardson D, Rousseau S, Quintanilla-Fend L, Quwailid MM, Racz I, Rathkolb B, Riet F, Rossant J, Roux M, Rozman J, Ryder E, Salisbury J, Santos L, Schäble KH, Schiller E, Schrewe A, Schulz H, Steinkamp R, Simon M, Stewart M, Stöger C, Stöger T, Sun M, Sunter D, Teboul L, Tilly I, Tocchini-Valentini GP, Tost M, Treise I, Vasseur L, Velot E, Vogt-Weisenhorn D, Wagner C, Walling A, Weber B, Wendling O, Westerberg H, Willershäuser M, Wolf E, Wolter A, Wood J, Wurst W, Yildirim AÖ, Zeh R, Zimmer A, Zimprich A, Holmes C, Steel KP, Herault Y, Gailus-Durner V, Mallon AM, Brown SD. Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics. Nat Genet. 2015 Sep; 47(9):969-978. PMID: 26214591.
      View in: PubMed
    14. Lloyd KC, Meehan T, Beaudet A, Murray S, Svenson K, McKerlie C, West D, Morse I, Parkinson H, Brown S, Mallon AM, Moore M. Precision medicine: Look to the mice. Science. 2015 Jul 24; 349(6246):390. PMID: 26206923; PMCID: PMC4960978.
      View in: PubMed, PubMed Central
    15. Lo KC, Yildiz C, Zhu Y, Lambourne MD, Mullen JB, Samplaski MK, Jarvi KA, McKerlie C. Human Fetal Testicular Tissue Xenotransplantation: A Platform to Study the Effect of Gonadotropins on Human Germ Cell Development In Utero. J Urol. 2015 Aug; 194(2):585-91. PMID: 25656291.
      View in: PubMed
    16. Adissu HA, Medhanie GA, Morikawa L, White JK, Newbigging S, McKerlie C. Right Ventricular Epicardial Fibrosis in Mice With Sternal Segment Dislocation. Vet Pathol. 2015 Sep; 52(5):967-76. PMID: 25281652; PMCID: PMC4469621.
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    17. Adissu HA, Estabel J, Sunter D, Tuck E, Hooks Y, Carragher DM, Clarke K, Karp NA, Newbigging S, Jones N, Morikawa L, White JK, McKerlie C. Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Dis Model Mech. 2014 May; 7(5):515-24. PMID: 24652767; PMCID: PMC4007403.
      View in: PubMed, PubMed Central
    18. Inoue S, Tomasini R, Rufini A, Elia AJ, Agostini M, Amelio I, Cescon D, Dinsdale D, Zhou L, Harris IS, Lac S, Silvester J, Li WY, Sasaki M, Haight J, Brüstle A, Wakeham A, McKerlie C, Jurisicova A, Melino G, Mak TW. TAp73 is required for spermatogenesis and the maintenance of male fertility. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):1843-8. PMID: 24449892; PMCID: PMC3918781.
      View in: PubMed, PubMed Central
    19. Schofield PN, Sundberg JP, Sundberg BA, McKerlie C, Gkoutos GV. The mouse pathology ontology, MPATH; structure and applications. J Biomed Semantics. 2013 Sep 13; 4(1):18. PMID: 24033988; PMCID: PMC3851164.
      View in: PubMed, PubMed Central
    20. Kelsey L, Flenniken AM, Qu D, Funnell AP, Pearson R, Zhou YQ, Voronina I, Berberovic Z, Wood G, Newbigging S, Weiss ES, Wong M, Quach I, Yeh SY, Deshwar AR, Scott IC, McKerlie C, Henkelman M, Backx P, Simpson J, Osborne L, Rossant J, Crossley M, Bruneau B, Adamson SL. ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice. PLoS Genet. 2013; 9(7):e1003612. PMID: 23874215; PMCID: PMC3708807.
      View in: PubMed, PubMed Central
    21. Yildiz C, Mullen B, Jarvi K, McKerlie C, Lo KC. Effect of different cryoprotectant agents on spermatogenesis efficiency in cryopreserved and grafted neonatal mouse testicular tissue. Cryobiology. 2013 Aug; 67(1):70-5. PMID: 23721968; PMCID: PMC4094018.
      View in: PubMed, PubMed Central
    22. Chang I, Bramall AN, Baynash AG, Rattner A, Rakheja D, Post M, Joza S, McKerlie C, Stewart DJ, McInnes RR, Yanagisawa M. Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun; 123(6):2643-53. PMID: 23676500; PMCID: PMC3668837.
      View in: PubMed, PubMed Central
    23. Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J, Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M, Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K, Koutsourakis M, Lloyd KC, Marschall S, Mason J, McKerlie C, McLeod MP, von Melchner H, Moore M, Mujica AO, Nagy A, Nefedov M, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R, Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N, Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, Schofield P, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D, Stanford WL, Stewart AF, Stone K, Swan K, Tadepally H, Teboul L, Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura K, Yoshinaga Y, Wurst W. The mammalian gene function resource: the International Knockout Mouse Consortium. Mamm Genome. 2012 Oct; 23(9-10):580-6. PMID: 22968824; PMCID: PMC3463800.
      View in: PubMed, PubMed Central
    24. Donahue LR, Hrabe de Angelis M, Hagn M, Franklin C, Lloyd KC, Magnuson T, McKerlie C, Nakagata N, Obata Y, Read S, Wurst W, Hörlein A, Davisson MT. Centralized mouse repositories. Mamm Genome. 2012 Oct; 23(9-10):559-71. PMID: 22945696; PMCID: PMC3709583.
      View in: PubMed, PubMed Central
    25. Kollmus H, Post R, Brielmeier M, Fernández J, Fuchs H, McKerlie C, Montoliu L, Otaegui PJ, Rebelo M, Riedesel H, Ruberte J, Sedlacek R, de Angelis MH, Schughart K. Structural and functional concepts in current mouse phenotyping and archiving facilities. J Am Assoc Lab Anim Sci. 2012 Jul; 51(4):418-35. PMID: 23043807; PMCID: PMC3400690.
      View in: PubMed, PubMed Central
    26. Ye L, Zhu W, Backx PH, Cortez MA, Wu J, Chow YH, McKerlie C, Wang A, Tsui LC, Gross GJ, Hu J. Arrhythmia and sudden death associated with elevated cardiac chloride channel activity. J Cell Mol Med. 2011 Nov; 15(11):2307-16. PMID: 21155978; PMCID: PMC3822942.
      View in: PubMed, PubMed Central
    27. Schofield PN, Dubus P, Klein L, Moore M, McKerlie C, Ward JM, Sundberg JP. Pathology of the laboratory mouse: an International Workshop on Challenges for High Throughput Phenotyping. Toxicol Pathol. 2011 Apr; 39(3):559-62. PMID: 21444746.
      View in: PubMed
    28. Yildiz C, Law N, Ottaviani P, Jarvi K, McKerlie C. Comparison of sperm quality and DNA integrity in mouse sperm exposed to various cooling velocities and osmotic stress. Theriogenology. 2010 Nov; 74(8):1420-30. PMID: 20728931.
      View in: PubMed
    29. Ng D, Pitcher GM, Szilard RK, Sertié A, Kanisek M, Clapcote SJ, Lipina T, Kalia LV, Joo D, McKerlie C, Cortez M, Roder JC, Salter MW, McInnes RR. Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. PLoS Biol. 2009 Feb 24; 7(2):e41. PMID: 19243221; PMCID: PMC2652390.
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    30. Liu L, Nutter LM, Law N, McKerlie C. Sperm freezing and in vitro fertilization in three substrains of C57BL/6 mice. J Am Assoc Lab Anim Sci. 2009 Jan; 48(1):39-43. PMID: 19245749; PMCID: PMC2694707.
      View in: PubMed, PubMed Central
    31. Schofield PN, Brown SD, Sundberg JP, Arends M, Warren MV, Dubus P, Ellender M, Fiette L, Rozell B, Quintanilla-Martinez L, Raspa M, Song JY, van der Valk M, McKerlie C. PRIME importance of pathology expertise. Nat Biotechnol. 2009 Jan; 27(1):24-5. PMID: 19131991.
      View in: PubMed
    32. Yildiz C, Fleming C, Ottaviani P, McKerlie C. Fresh and frozen-thawed sperm quality, nuclear DNA integrity, invitro fertility, embryo development, and live-born offspring of N-ethyl-N-nitrosourea (ENU) mice. Cryobiology. 2008 Oct; 57(2):156-62. PMID: 18700137.
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    33. Yang Y, McKerlie C, Lu Z, Wang L, Buchwald M. In vivo potential effects of adenovirus type 5 E1A and E1B on lung carcinogenesis and lymphoproliferative inflammation. J Virol. 2008 Aug; 82(16):8105-11. PMID: 18524829; PMCID: PMC2519581.
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    34. Deng H, Tang N, Stief AE, Mehta N, Baig E, Head R, Sleep G, Yang XZ, McKerlie C, Trudel S, Stewart AK, McCart JA. Oncolytic virotherapy for multiple myeloma using a tumour-specific double-deleted vaccinia virus. Leukemia. 2008 Dec; 22(12):2261-4. PMID: 18509356.
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    35. Nemati B, Atmodjo W, Gagnon S, Humes D, McKerlie C, Kaplan F, Sweezey NB. Glucocorticoid receptor disruption delays structural maturation in the lungs of newborn mice. Pediatr Pulmonol. 2008 Feb; 43(2):125-33. PMID: 18085690.
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    36. Grasso F, Engelberts D, Helm E, Frndova H, Jarvis S, Talakoub O, McKerlie C, Babyn P, Post M, Kavanagh BP. Negative-pressure ventilation: better oxygenation and less lung injury. Am J Respir Crit Care Med. 2008 Feb 15; 177(4):412-8. PMID: 18079496.
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    37. Liu L, Wood GA, Morikawa L, Ayearst R, Fleming C, McKerlie C. Restoration of fertility by orthotopic transplantation of frozen adult mouse ovaries. Hum Reprod. 2008 Jan; 23(1):122-8. PMID: 17993475.
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    38. Lee SU, Grigorian A, Pawling J, Chen IJ, Gao G, Mozaffar T, McKerlie C, Demetriou M. N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration. J Biol Chem. 2007 Nov 16; 282(46):33725-34. PMID: 17855338.
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    39. Yildiz C, Ottaviani P, Law N, Ayearst R, Liu L, McKerlie C. Effects of cryopreservation on sperm quality, nuclear DNA integrity, in vitro fertilization, and in vitro embryo development in the mouse. Reproduction. 2007 Mar; 133(3):585-95. PMID: 17379653.
      View in: PubMed
    40. Chen NJ, Mirtsos C, Suh D, Lu YC, Lin WJ, McKerlie C, Lee T, Baribault H, Tian H, Yeh WC. C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a. Nature. 2007 Mar 08; 446(7132):203-7. PMID: 17322907.
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    41. Roth-Kleiner M, Ridsdale R, Cao L, Kuliszewski M, Tseu I, McKerlie C, Post M. Lipopolysaccharide exposure modifies high tidal volume ventilation-induced proinflammatory mediator expression in newborn rat lungs. Pediatr Res. 2007 Feb; 61(2):191-6. PMID: 17237721.
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    42. Tremblay LO, Nagy Kovács E, Daniels E, Wong NK, Sutton-Smith M, Morris HR, Dell A, Marcinkiewicz E, Seidah NG, McKerlie C, Herscovics A. Respiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturation. J Biol Chem. 2007 Jan 26; 282(4):2558-66. PMID: 17121831.
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    43. Meyer J, Cox PN, McKerlie C, Bienzle D. Protective strategies of high-frequency oscillatory ventilation in a rabbit model. Pediatr Res. 2006 Oct; 60(4):401-6. PMID: 16940248.
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    44. Tsuchida S, Engelberts D, Peltekova V, Hopkins N, Frndova H, Babyn P, McKerlie C, Post M, McLoughlin P, Kavanagh BP. Atelectasis causes alveolar injury in nonatelectatic lung regions. Am J Respir Crit Care Med. 2006 Aug 01; 174(3):279-89. PMID: 16675780.
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    45. Gagnon S, Atmodjo W, Humes D, McKerlie C, Kaplan F, Sweezey NB. Transgenic glucocorticoid receptor expression driven by the SP-C promoter reduces neonatal lung cellularity and midkine expression in GRhypo mice. Biol Neonate. 2006; 90(1):46-57. PMID: 16534186.
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    46. McKerlie C. Cause and effect considerations in diagnostic pathology and pathology phenotyping of genetically engineered mice (GEM). ILAR J. 2006; 47(2):156-62. PMID: 16547372.
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    47. Wang Y, Vachon E, Zhang J, Cherepanov V, Kruger J, Li J, Saito K, Shannon P, Bottini N, Huynh H, Ni H, Yang H, McKerlie C, Quaggin S, Zhao ZJ, Marsden PA, Mustelin T, Siminovitch KA, Downey GP. Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function. J Exp Med. 2005 Dec 05; 202(11):1587-97. PMID: 16330817; PMCID: PMC2213338.
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    48. Koehler DR, Frndova H, Leung K, Louca E, Palmer D, Ng P, McKerlie C, Cox P, Coates AL, Hu J. Aerosol delivery of an enhanced helper-dependent adenovirus formulation to rabbit lung using an intratracheal catheter. J Gene Med. 2005 Nov; 7(11):1409-20. PMID: 15999396.
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    49. Flenniken AM, Osborne LR, Anderson N, Ciliberti N, Fleming C, Gittens JE, Gong XQ, Kelsey LB, Lounsbury C, Moreno L, Nieman BJ, Peterson K, Qu D, Roscoe W, Shao Q, Tong D, Veitch GI, Voronina I, Vukobradovic I, Wood GA, Zhu Y, Zirngibl RA, Aubin JE, Bai D, Bruneau BG, Grynpas M, Henderson JE, Henkelman RM, McKerlie C, Sled JG, Stanford WL, Laird DW, Kidder GM, Adamson SL, Rossant J. A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development. 2005 Oct; 132(19):4375-86. PMID: 16155213.
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    50. Tsuchida S, Engelberts D, Roth M, McKerlie C, Post M, Kavanagh BP. Continuous positive airway pressure causes lung injury in a model of sepsis. Am J Physiol Lung Cell Mol Physiol. 2005 Oct; 289(4):L554-64. PMID: 15923208.
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    51. Wood GA, Flenniken A, Osborne L, Fleming C, Vukobradovic I, Morikawa L, Xu Q, Porter R, Adamson SL, Rossant J, McKerlie C. Two mouse mutations mapped to chromosome 11 with differing morphologies but similar progressive inflammatory alopecia. Exp Dermatol. 2005 May; 14(5):373-9. PMID: 15854131.
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    52. Kornecki A, Tsuchida S, Ondiveeran HK, Engelberts D, Frndova H, Tanswell AK, Post M, McKerlie C, Belik J, Fox-Robichaud A, Kavanagh BP. Lung development and susceptibility to ventilator-induced lung injury. Am J Respir Crit Care Med. 2005 Apr 01; 171(7):743-52. PMID: 15640366.
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    53. Serbanescu I, Cortez MA, McKerlie C, Snead OC. Refractory atypical absence seizures in rat: a two hit model. Epilepsy Res. 2004 Nov; 62(1):53-63. PMID: 15519132.
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    54. Tribl B, Filipp D, Bödeker H, Yu P, Hammerrmüller I, McKerlie C, Keim V, Sibbald WJ. Pseudomonas pneumonia-mediated sepsis induces expression of pancreatitis-associated protein-I in rat pancreas. Pancreas. 2004 Jul; 29(1):33-40. PMID: 15211109.
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    55. Chow RL, Volgyi B, Szilard RK, Ng D, McKerlie C, Bloomfield SA, Birch DG, McInnes RR. Control of late off-center cone bipolar cell differentiation and visual signaling by the homeobox gene Vsx1. Proc Natl Acad Sci U S A. 2004 Feb 10; 101(6):1754-9. PMID: 14745032; PMCID: PMC341848.
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    56. Copland IB, Martinez F, Kavanagh BP, Engelberts D, McKerlie C, Belik J, Post M. High tidal volume ventilation causes different inflammatory responses in newborn versus adult lung. Am J Respir Crit Care Med. 2004 Mar 15; 169(6):739-48. PMID: 14711797.
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    57. Koehler DR, Sajjan U, Chow YH, Martin B, Kent G, Tanswell AK, McKerlie C, Forstner JF, Hu J. Protection of Cftr knockout mice from acute lung infection by a helper-dependent adenoviral vector expressing Cftr in airway epithelia. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15364-9. PMID: 14673110; PMCID: PMC307573.
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    58. Laffey JG, Jankov RP, Engelberts D, Tanswell AK, Post M, Lindsay T, Mullen JB, Romaschin A, Stephens D, McKerlie C, Kavanagh BP. Effects of therapeutic hypercapnia on mesenteric ischemia-reperfusion injury. Am J Respir Crit Care Med. 2003 Dec 01; 168(11):1383-90. PMID: 14644926.
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    59. Wong JC, Alon N, Mckerlie C, Huang JR, Meyn MS, Buchwald M. Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia. Hum Mol Genet. 2003 Aug 15; 12(16):2063-76. PMID: 12913077.
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    60. Copland IB, Kavanagh BP, Engelberts D, McKerlie C, Belik J, Post M. Early changes in lung gene expression due to high tidal volume. Am J Respir Crit Care Med. 2003 Nov 01; 168(9):1051-9. PMID: 12816737.
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    61. Kotsopoulos J, Sohn KJ, Martin R, Choi M, Renlund R, McKerlie C, Hwang SW, Medline A, Kim YI. Dietary folate deficiency suppresses N-methyl-N-nitrosourea-induced mammary tumorigenesis in rats. Carcinogenesis. 2003 May; 24(5):937-44. PMID: 12771039.
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    62. Pan Y, Zvaritch E, Tupling AR, Rice WJ, de Leon S, Rudnicki M, McKerlie C, Banwell BL, MacLennan DH. Targeted disruption of the ATP2A1 gene encoding the sarco(endo)plasmic reticulum Ca2+ ATPase isoform 1 (SERCA1) impairs diaphragm function and is lethal in neonatal mice. J Biol Chem. 2003 Apr 11; 278(15):13367-75. PMID: 12556521.
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    63. Haston CK, McKerlie C, Newbigging S, Corey M, Rozmahel R, Tsui LC. Detection of modifier loci influencing the lung phenotype of cystic fibrosis knockout mice. Mamm Genome. 2002 Nov; 13(11):605-13. PMID: 12461645.
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    64. Winer S, Astsaturov I, Cheung R, Tsui H, Song A, Gaedigk R, Winer D, Sampson A, McKerlie C, Bookman A, Dosch HM. Primary Sjögren's syndrome and deficiency of ICA69. Lancet. 2002 Oct 05; 360(9339):1063-9. PMID: 12383988.
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    65. Yang Y, McKerlie C, Borenstein SH, Lu Z, Schito M, Chamberlain JW, Buchwald M. Transgenic expression in mouse lung reveals distinct biological roles for the adenovirus type 5 E1A 243- and 289-amino-acid proteins. J Virol. 2002 Sep; 76(17):8910-9. PMID: 12163610; PMCID: PMC136987.
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    66. Winer S, Astsaturov I, Gaedigk R, Hammond-McKibben D, Pilon M, Song A, Kubiak V, Karges W, Arpaia E, McKerlie C, Zucker P, Singh B, Dosch HM. ICA69(null) nonobese diabetic mice develop diabetes, but resist disease acceleration by cyclophosphamide. J Immunol. 2002 Jan 01; 168(1):475-82. PMID: 11751995.
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    67. Rossant J, McKerlie C. Mouse-based phenogenomics for modelling human disease. Trends Mol Med. 2001 Nov; 7(11):502-7. PMID: 11689335.
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    68. Sajjan U, Thanassoulis G, Cherapanov V, Lu A, Sjolin C, Steer B, Wu YJ, Rotstein OD, Kent G, McKerlie C, Forstner J, Downey GP. Enhanced susceptibility to pulmonary infection with Burkholderia cepacia in Cftr(-/-) mice. Infect Immun. 2001 Aug; 69(8):5138-50. PMID: 11447196; PMCID: PMC98610.
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    69. Winer S, Astsaturov I, Cheung RK, Schrade K, Gunaratnam L, Wood DD, Moscarello MA, O'Connor P, McKerlie C, Becker DJ, Dosch HM. T cells of multiple sclerosis patients target a common environmental peptide that causes encephalitis in mice. J Immunol. 2001 Apr 01; 166(7):4751-6. PMID: 11254737.
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    70. Winer S, Astsaturov I, Cheung R, Gunaratnam L, Kubiak V, Cortez MA, Moscarello M, O'Connor PW, McKerlie C, Becker DJ, Dosch HM. Type I diabetes and multiple sclerosis patients target islet plus central nervous system autoantigens; nonimmunized nonobese diabetic mice can develop autoimmune encephalitis. J Immunol. 2001 Feb 15; 166(4):2831-41. PMID: 11160351.
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    71. Cortez MA, McKerlie C, Snead OC. A model of atypical absence seizures: EEG, pharmacology, and developmental characterization. Neurology. 2001 Feb 13; 56(3):341-9. PMID: 11171899.
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    72. Sheng-Tanner X, McKerlie C, Spaner D. Characterization of graft-versus-host disease in SCID mice and prevention by physicochemical stressors. Transplantation. 2000 Dec 27; 70(12):1683-93. PMID: 11152097.
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    73. Rimensberger PC, Pache JC, McKerlie C, Frndova H, Cox PN. Lung recruitment and lung volume maintenance: a strategy for improving oxygenation and preventing lung injury during both conventional mechanical ventilation and high-frequency oscillation. Intensive Care Med. 2000 Jun; 26(6):745-55. PMID: 10945393.
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    74. Morris KP, Cox PN, Mazer CD, Frndova H, McKerlie C, Wolfe R. Distribution of pulmonary blood flow in the perfluorocarbon-filled lung. Intensive Care Med. 2000 Jun; 26(6):756-63. PMID: 10945394.
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    75. Cano-Gauci DF, Song HH, Yang H, McKerlie C, Choo B, Shi W, Pullano R, Piscione TD, Grisaru S, Soon S, Sedlackova L, Tanswell AK, Mak TW, Yeger H, Lockwood GA, Rosenblum ND, Filmus J. Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome. J Cell Biol. 1999 Jul 12; 146(1):255-64. PMID: 10402475; PMCID: PMC2199732.
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    76. Carreau M, Gan OI, Liu L, Doedens M, McKerlie C, Dick JE, Buchwald M. Bone marrow failure in the Fanconi anemia group C mouse model after DNA damage. Blood. 1998 Apr 15; 91(8):2737-44. PMID: 9531583.
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    77. Kent G, Iles R, Bear CE, Huan LJ, Griesenbach U, McKerlie C, Frndova H, Ackerley C, Gosselin D, Radzioch D, O'Brodovich H, Tsui LC, Buchwald M, Tanswell AK. Lung disease in mice with cystic fibrosis. J Clin Invest. 1997 Dec 15; 100(12):3060-9. PMID: 9399953; PMCID: PMC508519.
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    78. Albert SE, McKerlie C, Pester A, Edgell BJ, Carlyle J, Petric M, Chamberlain JW. Time-dependent induction of protective anti-influenza immune responses in human peripheral blood lymphocyte/SCID mice. J Immunol. 1997 Aug 01; 159(3):1393-403. PMID: 9233636.
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    79. Chen M, Tomkins DJ, Auerbach W, McKerlie C, Youssoufian H, Liu L, Gan O, Carreau M, Auerbach A, Groves T, Guidos CJ, Freedman MH, Cross J, Percy DH, Dick JE, Joyner AL, Buchwald M. Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia. Nat Genet. 1996 Apr; 12(4):448-51. PMID: 8630504.
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