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Nicola Jones

TitleStaff Physician
InstitutionThe Hospital for Sick Children
DepartmentGastroenterology, Hepatology and Nutrition
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Biography 
    Collapse education and training
    University of Toronto, TorontoPh.D1999Molecular and Medical Genetics
    The Hospital for Sick Children, Toronto1999Pediatric Gastroenterology and Nutrition
    University of Toronto, TorontoM.D.1989Department of Medicine
    Queen's University, KingstonBSc1985
    Collapse awards and honors
    2014Canadian Association of Gastroenterology Education Excellence Award , Canadian Association of Gastroenterology
    2012Canadian Association of Gastroenterology Visiting Research Professorship Award, Canadian Association of Gastroenterology
    2009Canadian Association of Gastroenterology Young Educator Award, Canadian Association of Gastroenterology
    2005Canadian Association of Gastroenterology Young Investigator Award, Canadian Association of Gastroenterology
    2004Department of Paediatrics Junior Faculty Research Award, University of Toronto
    2003Department of Physiology Excellence in Teaching Award, University of Toronto
    2000Young Investigator Travel Award, World Congress of Pediatric Gastroenterology

    Collapse Research 
    Collapse research activities and funding
         (Nicola Jones)Jul 1, 2015 - Jun 30, 2018
    Crohn’s and Colitis Canada
    Epigenetic regulation of autophagy: linking environmental gene interactions in inflammatory bowel disease
    Role: PI

         (Nicola Jones)Jul 1, 2015 - Jun 30, 2020
    CIHR
    Role of autophagy in Helicobacter pylori infection and disease
    Role: PI

         (Nicola Jones)Dec 31, 2016 - Dec 30, 2018
    NASPGHAN/AstraZeneca
    Novel non-antibiotic, mechanism-based therapy to treat Helicobacter pylori infections
    Role: PI

         (Nicola Jones)Jan 1, 2017 - Dec 31, 2019
    OSSU Patient-Oriented Research Capacity Building Initiatives Awards
    Patient oriented research curriculum for children, families and clinician scientists in child health (PORCCH)
    Role: PI

         (Nicola Jones)Jan 11, 2017 - May 31, 2018
    Physician Scientist Institutional Award, Burroughs Wellcome Fund
    Training new cohorts of physician scientists at University of Toronto Medicine: Novel strategies to engage and train ‘Late Bloomers’
    Role: PI

         (Catharine Walsh)Mar 1, 2018 - Feb 28, 2019
    CIHR
    Evaluation of a Patient Oriented Research Curriculum in Child Health (PORCCH)
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Benchimol EI, Jones NL, Muise AM, Sherman PM. 2019 Harry Shwachman Award: Dr Anne M. Griffiths, MD, FRCPC. J Pediatr Gastroenterol Nutr. 2020 Apr; 70(4):405. PMID: 31880672.
      View in: PubMed
    2. Capurro MI, Greenfield LK, Prashar A, Xia S, Abdullah M, Wong H, Zhong XZ, Bertaux-Skeirik N, Chakrabarti J, Siddiqui I, O'Brien C, Dong X, Robinson L, Peek RM, Philpott DJ, Zavros Y, Helmrath M, Jones NL. VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1. Nat Microbiol. 2019 08; 4(8):1411-1423. PMID: 31110360.
      View in: PubMed
    3. Abdullah M, Greenfield LK, Bronte-Tinkew D, Capurro MI, Rizzuti D, Jones NL. VacA promotes CagA accumulation in gastric epithelial cells during Helicobacter pylori infection. Sci Rep. 2019 01 10; 9(1):38. PMID: 30631092.
      View in: PubMed
    4. Jones NL, Koletzko S, Goodman K, Bontems P, Cadranel S, Casswall T, Czinn S, Gold BD, Guarner J, Elitsur Y, Homan M, Kalach N, Kori M, Madrazo A, Megraud F, Papadopoulou A, Rowland M. Joint ESPGHAN/NASPGHAN Guidelines for the Management of Helicobacter pylori in Children and Adolescents (Update 2016). J Pediatr Gastroenterol Nutr. 2017 06; 64(6):991-1003. PMID: 28541262.
      View in: PubMed
    5. Wu RY, Abdullah M, Määttänen P, Pilar AV, Scruten E, Johnson-Henry KC, Napper S, O'Brien C, Jones NL, Sherman PM. Protein kinase C d signaling is required for dietary prebiotic-induced strengthening of intestinal epithelial barrier function. Sci Rep. 2017 01 18; 7:40820. PMID: 28098206.
      View in: PubMed
    6. Fallone CA, Gisbert JP, Chiba N, Veldhuyzen van Zanten S, Fischbach L, Hunt RH, Jones NL, Render C, Leontiadis GI, Moayyedi P, Marshall JK. Reply. Gastroenterology. 2017 01; 152(1):303-304. PMID: 27893977.
      View in: PubMed
    7. Fallone CA, Chiba N, van Zanten SV, Fischbach L, Gisbert JP, Hunt RH, Jones NL, Render C, Leontiadis GI, Moayyedi P, Marshall JK. The Toronto Consensus for the Treatment of Helicobacter pylori Infection in Adults. Gastroenterology. 2016 Jul; 151(1):51-69.e14. PMID: 27102658.
      View in: PubMed
    8. Sibony M, Abdullah M, Greenfield L, Raju D, Wu T, Rodrigues DM, Galindo-Mata E, Mascarenhas H, Philpott DJ, Silverberg MS, Jones NL. Microbial Disruption of Autophagy Alters Expression of the RISC Component AGO2, a Critical Regulator of the miRNA Silencing Pathway. Inflamm Bowel Dis. 2015 Dec; 21(12):2778-86. PMID: 26332312.
      View in: PubMed
    9. Rizzuti D, Ang M, Sokollik C, Wu T, Abdullah M, Greenfield L, Fattouh R, Reardon C, Tang M, Diao J, Schindler C, Cattral M, Jones NL. Helicobacter pylori inhibits dendritic cell maturation via interleukin-10-mediated activation of the signal transducer and activator of transcription 3 pathway. J Innate Immun. 2015; 7(2):199-211. PMID: 25412627.
      View in: PubMed
    10. Greenfield LK, Jones NL. Modulation of autophagy by Helicobacter pylori and its role in gastric carcinogenesis. Trends Microbiol. 2013 Nov; 21(11):602-12. PMID: 24156875.
      View in: PubMed
    11. Raju D, Hussey S, Jones NL. Crohn disease ATG16L1 polymorphism increases susceptibility to infection with Helicobacter pylori in humans. Autophagy. 2012 Sep; 8(9):1387-8. PMID: 22885761.
      View in: PubMed
    12. Raju D, Hussey S, Ang M, Terebiznik MR, Sibony M, Galindo-Mata E, Gupta V, Blanke SR, Delgado A, Romero-Gallo J, Ramjeet MS, Mascarenhas H, Peek RM, Correa P, Streutker C, Hold G, Kunstmann E, Yoshimori T, Silverberg MS, Girardin SE, Philpott DJ, El Omar E, Jones NL. Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans. Gastroenterology. 2012 May; 142(5):1160-71. PMID: 22333951.
      View in: PubMed
    13. Jones N, Chiba N, Fallone C, Thompson A, Hunt R, Jacobson K, Goodman K. Helicobacter pylori in First Nations and recent immigrant populations in Canada. Can J Gastroenterol. 2012 Feb; 26(2):97-103. PMID: 22312609.
      View in: PubMed
    14. Jones NL, Chiba N, Fallone C, Hunt R, Thomson A. Helicobacter pylori and immigrant health. CMAJ. 2012 Jan 10; 184(1):74-5. PMID: 22232338.
      View in: PubMed
    15. Raju D, Rizzuti D, Jones NL. Cell culture-based assays to test for bacterial adherence and internalization. Methods Mol Biol. 2012; 921:69-76. PMID: 23015493.
      View in: PubMed
    16. Raju D, Rizzuti D, Jones NL. Cell culture assays to evaluate bacterial toxicity and virulence. Methods Mol Biol. 2012; 921:77-88. PMID: 23015494.
      View in: PubMed
    17. Sibony M, Jones NL. Recent advances in Helicobacter pylori pathogenesis. Curr Opin Gastroenterol. 2012 Jan; 28(1):30-5. PMID: 22157439.
      View in: PubMed
    18. O'Connor PM, Lapointe TK, Jackson S, Beck PL, Jones NL, Buret AG. Helicobacter pylori activates calpain via toll-like receptor 2 to disrupt adherens junctions in human gastric epithelial cells. Infect Immun. 2011 Oct; 79(10):3887-94. PMID: 21825064.
      View in: PubMed
    19. Jones NL, Croitoru K, Vanner S, Soni R, Hope L. Research Topics in Gastrointestinal Disease: a report on the 10th meeting and an announcement of the 11th meeting. Can J Gastroenterol. 2011 Aug; 25(8):449-50. PMID: 21912771.
      View in: PubMed
    20. Koletzko S, Jones NL, Goodman KJ, Gold B, Rowland M, Cadranel S, Chong S, Colletti RB, Casswall T, Elitsur Y, Guarner J, Kalach N, Madrazo A, Megraud F, Oderda G. Evidence-based guidelines from ESPGHAN and NASPGHAN for Helicobacter pylori infection in children. J Pediatr Gastroenterol Nutr. 2011 Aug; 53(2):230-43. PMID: 21558964.
      View in: PubMed
    21. Mourad-Baars P, Hussey S, Jones NL. Helicobacter pylori infection and childhood. Helicobacter. 2010 Sep; 15 Suppl 1:53-9. PMID: 21054654.
      View in: PubMed
    22. Raju D, Jones NL. Methods to monitor autophagy in H. pylori vacuolating cytotoxin A (VacA)-treated cells. Autophagy. 2010 Jan; 6(1):138-43. PMID: 19875940.
      View in: PubMed
    23. Shen-Tu G, Schauer DB, Jones NL, Sherman PM. Detergent-resistant microdomains mediate activation of host cell signaling in response to attaching-effacing bacteria. Lab Invest. 2010 Feb; 90(2):266-81. PMID: 19997063.
      View in: PubMed
    24. Hussey S, Travassos LH, Jones NL. Autophagy as an emerging dimension to adaptive and innate immunity. Semin Immunol. 2009 Aug; 21(4):233-41. PMID: 19502083.
      View in: PubMed
    25. Terebiznik MR, Raju D, Vázquez CL, Torbricki K, Kulkarni R, Blanke SR, Yoshimori T, Colombo MI, Jones NL. Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells. Autophagy. 2009 Apr; 5(3):370-9. PMID: 19164948.
      View in: PubMed
    26. Hussey S, Terebiznik MR, Jones NL. Autophagy: healthy eating and self-digestion for gastroenterologists. J Pediatr Gastroenterol Nutr. 2008 May; 46(5):496-506. PMID: 18493203.
      View in: PubMed
    27. Avitzur Y, Galindo-Mata E, Jones NL. Oral vaccination against Helicobacter pylori infection is not effective in mice with Fas ligand deficiency. Dig Dis Sci. 2005 Dec; 50(12):2300-6. PMID: 16416178.
      View in: PubMed
    28. Jones NL, Wine E. Pediatric gastrointestinal diseases: are drugs the answer? Curr Opin Pharmacol. 2005 Dec; 5(6):604-9. PMID: 16199203.
      View in: PubMed
    29. Bourke B, Ceponis P, Chiba N, Czinn S, Ferraro R, Fischbach L, Gold B, Hyunh H, Jacobson K, Jones NL, Koletzko S, Lebel S, Moayyedi P, Ridell R, Sherman P, van Zanten S, Beck I, Best L, Boland M, Bursey F, Chaun H, Cooper G, Craig B, Creuzenet C, Critch J, Govender K, Hassall E, Kaplan A, Keelan M, Noad G, Robertson M, Smith L, Stein M, Taylor D, Walters T, Persaud R, Whitaker S, Woodland R. Canadian Helicobacter Study Group Consensus Conference: Update on the approach to Helicobacter pylori infection in children and adolescents--an evidence-based evaluation. Can J Gastroenterol. 2005 Jul; 19(7):399-408. PMID: 16010300.
      View in: PubMed
    30. Ceponis PJ, Jones NL. Modulation of host cell signal transduction pathways by Helicobacter pylori infection. Can J Gastroenterol. 2005 Jul; 19(7):415-20. PMID: 16010303.
      View in: PubMed
    31. Johnson-Henry KC, Nadjafi M, Avitzur Y, Mitchell DJ, Ngan BY, Galindo-Mata E, Jones NL, Sherman PM. Amelioration of the effects of Citrobacter rodentium infection in mice by pretreatment with probiotics. J Infect Dis. 2005 Jun 15; 191(12):2106-17. PMID: 15897997.
      View in: PubMed
    32. Menaker RJ, Sharaf AA, Jones NL. Helicobacter pylori infection and gastric cancer: host, bug, environment, or all three? Curr Gastroenterol Rep. 2004 Dec; 6(6):429-35. PMID: 15527671.
      View in: PubMed
    33. Jones NL. A review of current guidelines for the management of Helicobacter pylori infection in children and adolescents. Paediatr Child Health. 2004 Dec; 9(10):709-713. PMID: 19688080.
      View in: PubMed
    34. Day AS, Su B, Ceponis PJ, Jones NL, Yau E, Sieveking D, Sherman PM. Helicobacter pylori infection induces interleukin-18 production in gastric epithelial (AGS) cells. Dig Dis Sci. 2004 Nov-Dec; 49(11-12):1830-5. PMID: 15628712.
      View in: PubMed
    35. Johnson-Henry KC, Mitchell DJ, Avitzur Y, Galindo-Mata E, Jones NL, Sherman PM. Probiotics reduce bacterial colonization and gastric inflammation in H. pylori-infected mice. Dig Dis Sci. 2004 Aug; 49(7-8):1095-102. PMID: 15387328.
      View in: PubMed
    36. Menaker RJ, Ceponis PJ, Jones NL. Helicobacter pylori induces apoptosis of macrophages in association with alterations in the mitochondrial pathway. Infect Immun. 2004 May; 72(5):2889-98. PMID: 15102801.
      View in: PubMed
    37. Mitchell DJ, Huynh HQ, Ceponis PJ, Jones NL, Sherman PM. Helicobacter pylori disrupts STAT1-mediated gamma interferon-induced signal transduction in epithelial cells. Infect Immun. 2004 Jan; 72(1):537-45. PMID: 14688135.
      View in: PubMed
    38. Menaker RJ, Jones NL. Fascination with bacteria-triggered cell death: the significance of Fas-mediated apoptosis during bacterial infection in vivo. Microbes Infect. 2003 Oct; 5(12):1149-58. PMID: 14554257.
      View in: PubMed
    39. Ceponis PJ, McKay DM, Menaker RJ, Galindo-Mata E, Jones NL. Helicobacter pylori infection interferes with epithelial Stat6-mediated interleukin-4 signal transduction independent of cagA, cagE, or VacA. J Immunol. 2003 Aug 15; 171(4):2035-41. PMID: 12902508.
      View in: PubMed
    40. Zheng PY, Jones NL. Recent advances in Helicobacter pylori infection in children: from the petri dish to the playground. Can J Gastroenterol. 2003 Jul; 17(7):448-54. PMID: 12915920.
      View in: PubMed
    41. Jones NL. Detection of Shiga toxin-mediated programmed cell death and delineation of death-signaling pathways. Methods Mol Med. 2003; 73:229-41. PMID: 12375433.
      View in: PubMed
    42. Zheng PY, Jones NL. Helicobacter pylori strains expressing the vacuolating cytotoxin interrupt phagosome maturation in macrophages by recruiting and retaining TACO (coronin 1) protein. Cell Microbiol. 2003 Jan; 5(1):25-40. PMID: 12542468.
      View in: PubMed
    43. Ching JC, Jones NL, Ceponis PJ, Karmali MA, Sherman PM. Escherichia coli shiga-like toxins induce apoptosis and cleavage of poly(ADP-ribose) polymerase via in vitro activation of caspases. Infect Immun. 2002 Aug; 70(8):4669-77. PMID: 12117981.
      View in: PubMed
    44. Jones NL, Day AS, Jennings H, Shannon PT, Galindo-Mata E, Sherman PM. Enhanced disease severity in Helicobacter pylori-infected mice deficient in Fas signaling. Infect Immun. 2002 May; 70(5):2591-7. PMID: 11953400.
      View in: PubMed
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