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Margaret Rand

TitleScientist
InstitutionThe Hospital for Sick Children
DepartmentTranslational Medicine
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Carcao MD, Chelle P, Clarke E, Kim L, Tiseo L, Morfini M, Hossain T, Rand ML, Brown C, Edginton AN, Lillicrap D, Iorio A, Blanchette VS. Comparative pharmacokinetics of two extended half-life FVIII concentrates (Eloctate and Adynovate) in adolescents with hemophilia A: Is there a difference? J Thromb Haemost. 2019 Jul; 17(7):1085-1096. PMID: 31038793.
      View in: PubMed
    2. Bui J, Martyres D, James PD, Grabell J, Wu J, Steele M, Silva M, Rand ML, Blanchette VS, Barrowman N, Klaassen RJ. Validation of the school age self-administered pediatric bleeding questionnaire (Self-PBQ) in children aged 8-12 years. Pediatr Blood Cancer. 2019 Jun; 66(6):e27709. PMID: 30900820.
      View in: PubMed
    3. Xu XR, Wang Y, Adili R, Ju L, Spring CM, Jin JW, Yang H, Neves MAD, Chen P, Yang Y, Lei X, Chen Y, Gallant RC, Xu M, Zhang H, Song J, Ke P, Zhang D, Carrim N, Yu SY, Zhu G, She YM, Cyr T, Fu W, Liu G, Connelly PW, Rand ML, Adeli K, Freedman J, Lee JE, Tso P, Marchese P, Davidson WS, Jackson SP, Zhu C, Ruggeri ZM, Ni H. Apolipoprotein A-IV binds aIIbß3 integrin and inhibits thrombosis. Nat Commun. 2018 09 06; 9(1):3608. PMID: 30190457.
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    4. Reddy EC, Wang H, Christensen H, McMillan-Ward E, Israels SJ, Bang KWA, Rand ML. Analysis of procoagulant phosphatidylserine-exposing platelets by imaging flow cytometry. Res Pract Thromb Haemost. 2018 Oct; 2(4):736-750. PMID: 30349893.
      View in: PubMed
    5. Pelland-Marcotte MC, Humpl T, James PD, Rand ML, Bouskill V, Reyes JT, Bowman ML, Carcao MD. Idiopathic pulmonary arterial hypertension - a unrecognized cause of high-shear high-flow haemostatic defects (otherwise referred to as acquired von Willebrand syndrome) in children. Br J Haematol. 2018 10; 183(2):267-275. PMID: 30141279.
      View in: PubMed
    6. Rand ML, Reddy EC, Israels SJ. Laboratory diagnosis of inherited platelet function disorders. Transfus Apher Sci. 2018 Aug; 57(4):485-493. PMID: 30054199.
      View in: PubMed
    7. Wharfe G, Buchner-Daley L, Gibson T, Hilliard P, Usuba K, Abad A, Boma-Fischer L, Bouskill V, Floros G, Lillicrap D, Lowe Y, Lowe D, Palmer-Mitchell N, Rand ML, Teitel J, Tuttle A, Watson A, White R, Young NL, Blanchette VS. The Jamaican Haemophilia Registry: Describing the burden of disease. Haemophilia. 2018 Jul; 24(4):e179-e186. PMID: 29855125.
      View in: PubMed
    8. Stokhuijzen E, Rand ML, Cnossen MH, Biss TT, James PD, Suijker MH, Peters M, van der Lee JH, Peters B, Meijer AB, Blanchette VS, Fijnvandraat K. Identifying Children with HEreditary Coagulation disorders (iCHEC): a protocol for a prospective cohort study. BMJ Open. 2018 05 03; 8(5):e020686. PMID: 29724741.
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    9. Stokhuijzen E, Segbefia CI, Biss TT, Clark DS, James PD, Riddel J, Blanchette VS, Rand ML. Severity and Features of Epistaxis in Children with a Mucocutaneous Bleeding Disorder. J Pediatr. 2018 02; 193:183-189.e2. PMID: 29198540.
      View in: PubMed
    10. Pakdeeto S, Natesirinilkul R, Komwilaisak P, Rand ML, Blanchette VS, Vallibhakara SA, Sirachainan N. Development of a Thai version of the paediatric bleeding assessment tool (Thai paediatric-BAT) suitable for use in children with inherited mucocutaneous bleeding disorders. Haemophilia. 2017 11; 23(6):e539-e542. PMID: 28994494.
      View in: PubMed
    11. Casey LJ, Klaassen RJ, Rand ML, James PD. Reply to comment on: Generation and optimization of the self-administered pediatric bleeding questionnaire and its validation as a screening tool for von Willebrand disease. Pediatr Blood Cancer. 2017 12; 64(12). PMID: 28792666.
      View in: PubMed
    12. Al-Battat S, Rand ML, Bouskill V, Lau W, Blanchette VS, Kahr WHA, Rivard GE, Carcao MD. Glanzmann thrombasthenia platelets compete with transfused platelets, reducing the haemostatic impact of platelet transfusions. Br J Haematol. 2018 05; 181(3):410-413. PMID: 28466602.
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    13. Casey LJ, Tuttle A, Grabell J, Hopman W, Moorehead PC, Blanchette VS, Wu JK, Steele M, Klaassen RJ, Silva M, Rand ML, James PD. Generation and optimization of the self-administered pediatric bleeding questionnaire and its validation as a screening tool for von Willebrand disease. Pediatr Blood Cancer. 2017 Oct; 64(10). PMID: 28453185.
      View in: PubMed
    14. Reddy EC, Wang H, Bang KWA, Packham MA, Rand ML. Young steady-state rabbit platelets do not have an enhanced capacity to expose procoagulant phosphatidylserine. Platelets. 2018 Jan; 29(1):27-33. PMID: 28406717.
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    15. Sholzberg M, Floros G, Schneiderman JE, Kahr WH, Rand M, Pluthero F, Hossain T, Mahamad S, Nisenbaum R, Zhang C, O'Neill NE, Teitel J, Carcao M. Effect of moderate intensity exercise on haemostatic capacity in adults with haemophilia A and B: pilot study. Haemophilia. 2017 03; 23(2):e162-e165. PMID: 28111839.
      View in: PubMed
    16. Urban D, Pluthero FG, Christensen H, Baidya S, Rand ML, Das A, Shah PS, Chitayat D, Blanchette VS, Kahr WH. Decreased numbers of dense granules in fetal and neonatal platelets. Haematologica. 2017 02; 102(2):e36-e38. PMID: 27810994.
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    17. Kuo KH, Khan S, Rand ML, Mian HS, Brnjac E, Sandercock LE, Akula I, Julien JP, Pai EF, Chesney AE. EspP, an Extracellular Serine Protease from Enterohemorrhagic E. coli, Reduces Coagulation Factor Activities, Reduces Clot Strength, and Promotes Clot Lysis. PLoS One. 2016; 11(3):e0149830. PMID: 26934472.
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    18. Kumar R, Bouskill V, Schneiderman JE, Pluthero FG, Kahr WH, Craik A, Clark D, Whitney K, Zhang C, Rand ML, Carcao M. Impact of aerobic exercise on haemostatic indices in paediatric patients with haemophilia. Thromb Haemost. 2016 06 02; 115(6):1120-8. PMID: 26917411.
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    19. Nurden AT, Pillois X, Fiore M, Alessi MC, Bonduel M, Dreyfus M, Goudemand J, Gruel Y, Benabdallah-Guerida S, Latger-Cannard V, Négrier C, Nugent D, Oiron RD, Rand ML, Sié P, Trossaert M, Alberio L, Martins N, Sirvain-Trukniewicz P, Couloux A, Canault M, Fronthroth JP, Fretigny M, Nurden P, Heilig R, Vinciguerra C. Expanding the Mutation Spectrum Affecting aIIbß3 Integrin in Glanzmann Thrombasthenia: Screening of the ITGA2B and ITGB3 Genes in a Large International Cohort. Hum Mutat. 2015 May; 36(5):548-61. PMID: 25728920.
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    20. Schmugge M, Speer O, Kroiss S, Knirsch W, Kretschmar O, Rand ML, Albisetti M. Monitoring aspirin therapy in children after interventional cardiac catheterization: laboratory measures, dose response, and clinical outcomes. Eur J Pediatr. 2015 Jul; 174(7):933-41. PMID: 25589198.
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    21. Avila ML, Lee KJ, Bouskill V, Rand ML, James P, Carcao M. Acquired von Willebrand syndrome in paediatric patients with congenital heart disease: challenges in the diagnosis and management of this rare condition. Haemophilia. 2015 Jan; 21(1):e89-92. PMID: 25495773.
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    22. Elbatarny M, Mollah S, Grabell J, Bae S, Deforest M, Tuttle A, Hopman W, Clark DS, Mauer AC, Bowman M, Riddel J, Christopherson PA, Montgomery RR, Rand ML, Coller B, James PD. Normal range of bleeding scores for the ISTH-BAT: adult and pediatric data from the merging project. Haemophilia. 2014 Nov; 20(6):831-5. PMID: 25196510.
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    23. Wang Y, Reheman A, Spring CM, Kalantari J, Marshall AH, Wolberg AS, Gross PL, Weitz JI, Rand ML, Mosher DF, Freedman J, Ni H. Plasma fibronectin supports hemostasis and regulates thrombosis. J Clin Invest. 2014 Oct; 124(10):4281-93. PMID: 25180602.
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    24. Savoia A, Kunishima S, De Rocco D, Zieger B, Rand ML, Pujol-Moix N, Caliskan U, Tokgoz H, Pecci A, Noris P, Srivastava A, Ward C, Morel-Kopp MC, Alessi MC, Bellucci S, Beurrier P, de Maistre E, Favier R, Hézard N, Hurtaud-Roux MF, Latger-Cannard V, Lavenu-Bombled C, Proulle V, Meunier S, Négrier C, Nurden A, Randrianaivo H, Fabris F, Platokouki H, Rosenberg N, HadjKacem B, Heller PG, Karimi M, Balduini CL, Pastore A, Lanza F. Spectrum of the mutations in Bernard-Soulier syndrome. Hum Mutat. 2014 Sep; 35(9):1033-45. PMID: 24934643.
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    25. Wang H, Bang KW, Blanchette VS, Nurden AT, Rand ML. Phosphatidylserine exposure, microparticle formation and mitochondrial depolarisation in Glanzmann thrombasthenia platelets. Thromb Haemost. 2014 Jun; 111(6):1184-6. PMID: 24477274.
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    26. Winkler J, Rand ML, Schmugge M, Speer O. Omi/HtrA2 and XIAP are components of platelet apoptosis signalling. Thromb Haemost. 2013 Mar; 109(3):532-9. PMID: 23306356.
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    27. Israels SJ, Rand ML. What we have learned from inherited platelet disorders. Pediatr Blood Cancer. 2013; 60 Suppl 1:S2-7. PMID: 23109117.
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    28. Rand ML, Wang H, Pluthero FG, Stafford AR, Ni R, Vaezzadeh N, Allison AC, Kahr WH, Weitz JI, Gross PL. Diannexin, an annexin A5 homodimer, binds phosphatidylserine with high affinity and is a potent inhibitor of platelet-mediated events during thrombus formation. J Thromb Haemost. 2012 Jun; 10(6):1109-19. PMID: 22463102.
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    29. Winkler J, Kroiss S, Rand ML, Azzouzi I, Annie Bang KW, Speer O, Schmugge M. Platelet apoptosis in paediatric immune thrombocytopenia is ameliorated by intravenous immunoglobulin. Br J Haematol. 2012 Feb; 156(4):508-15. PMID: 22171764.
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    30. Robertson JD, Yenson PR, Rand ML, Blanchette VS, Carcao MD, Notley C, Lillicrap D, James PD. Expanded phenotype-genotype correlations in a pediatric population with type 1 von Willebrand disease. J Thromb Haemost. 2011 Sep; 9(9):1752-60. PMID: 21711445.
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    31. Packham MA, Rand ML. Historical perspective on ADP-induced platelet activation. Purinergic Signal. 2011 Sep; 7(3):283-92. PMID: 21484086.
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    32. Israels SJ, Kahr WH, Blanchette VS, Luban NL, Rivard GE, Rand ML. Platelet disorders in children: A diagnostic approach. Pediatr Blood Cancer. 2011 Jun; 56(6):975-83. PMID: 21294245.
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    33. Poon MC, Rand ML, Jackson SC. 2B or not to be--the 45-year saga of the Montreal Platelet Syndrome. Thromb Haemost. 2010 Nov; 104(5):903-10. PMID: 20838735.
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    34. Rand ML, Wang H, Bang KW, Teitel JM, Blanchette VS, Freedman J, Nurden AT. Phosphatidylserine exposure and other apoptotic-like events in Bernard-Soulier syndrome platelets. Am J Hematol. 2010 Aug; 85(8):584-92. PMID: 20658588.
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    35. Gwozdz AM, Leung R, Wang H, Bang KW, Packham MA, Freedman J, Rand ML. Calpain inhibition by calpeptin does not prevent APLT activity reduction in PS-exposing platelets, but calpeptin has independent pro-apoptotic effects. Thromb Haemost. 2010 Jun; 103(6):1218-27. PMID: 20352156.
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    36. Biss TT, Blanchette VS, Clark DS, Wakefield CD, James PD, Rand ML. Use of a quantitative pediatric bleeding questionnaire to assess mucocutaneous bleeding symptoms in children with a platelet function disorder. J Thromb Haemost. 2010 Jun; 8(6):1416-9. PMID: 20236392.
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    37. Biss TT, Blanchette VS, Clark DS, Bowman M, Wakefield CD, Silva M, Lillicrap D, James PD, Rand ML. Quantitation of bleeding symptoms in children with von Willebrand disease: use of a standardized pediatric bleeding questionnaire. J Thromb Haemost. 2010 May; 8(5):950-6. PMID: 20136710.
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    38. Revel-Vilk S, Blanchette VS, Schmugge M, Clark DS, Lillicrap D, Rand ML. In vitro and in vivo stability of diluted recombinant factor VIII for continuous infusion use in haemophilia A. Haemophilia. 2010 Jan; 16(1):72-9. PMID: 19765092.
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    39. Bowman M, Riddel J, Rand ML, Tosetto A, Silva M, James PD. Evaluation of the diagnostic utility for von Willebrand disease of a pediatric bleeding questionnaire. J Thromb Haemost. 2009 Aug; 7(8):1418-21. PMID: 19496919.
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    40. Jackson SC, Sinclair GD, Cloutier S, Duan Z, Rand ML, Poon MC. The Montreal platelet syndrome kindred has type 2B von Willebrand disease with the VWF V1316M mutation. Blood. 2009 Apr 02; 113(14):3348-51. PMID: 19060241.
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    41. Rand ML, Wang H, Bang KW, Packham MA, Freedman J. Persistence of phosphatidylserine exposure on activated platelets in vivo in rabbits. Thromb Haemost. 2007 Aug; 98(2):477-8. PMID: 17721637.
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    42. Leung R, Gwozdz AM, Wang H, Bang KW, Packham MA, Freedman J, Rand ML. Persistence of procoagulant surface expression on activated human platelets: involvement of apoptosis and aminophospholipid translocase activity. J Thromb Haemost. 2007 Mar; 5(3):560-70. PMID: 17155950.
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    43. Schmugge M, Bang KW, Blanchette VS, Albisetti M, Connolly BL, Freedman J, Rand ML. Platelet activation and von Willebrand factor binding to platelets in newborn infants with central venous lines. Acta Haematol. 2007; 117(3):145-8. PMID: 17159336.
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    44. Rand ML, Wang H, Bang KW, Packham MA, Freedman J. Rapid clearance of procoagulant platelet-derived microparticles from the circulation of rabbits. J Thromb Haemost. 2006 Jul; 4(7):1621-3. PMID: 16839364.
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    45. Hedlund-Treutiger I, Revel-Vilk S, Blanchette VS, Curtin JA, Lillicrap D, Rand ML. Reliability and reproducibility of classification of children as "bleeders" versus "non-bleeders" using a questionnaire for significant mucocutaneous bleeding. J Pediatr Hematol Oncol. 2004 Aug; 26(8):488-91. PMID: 15284585.
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    46. Nurden AT, Breillat C, Jacquelin B, Combrié R, Freedman J, Blanchette VS, Schmugge M, Rand ML. Triple heterozygosity in the integrin alphaIIb subunit in a patient with Glanzmann's thrombasthenia. J Thromb Haemost. 2004 May; 2(5):813-9. PMID: 15099289.
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    47. Rand ML, Wang H, Bang KW, Poon KS, Packham MA, Freedman J. Procoagulant surface exposure and apoptosis in rabbit platelets: association with shortened survival and steady-state senescence. J Thromb Haemost. 2004 Apr; 2(4):651-9. PMID: 15102022.
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    48. Schmugge M, Dunn MS, Amankwah KS, Blanchette VS, Freedman J, Rand ML. The activity of the von Willebrand factor cleaving protease ADAMTS-13 in newborn infants. J Thromb Haemost. 2004 Feb; 2(2):228-33. PMID: 14995983.
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    49. Revel-Vilk S, Schmugge M, Carcao MD, Blanchette P, Rand ML, Blanchette VS. Desmopressin (DDAVP) responsiveness in children with von Willebrand disease. J Pediatr Hematol Oncol. 2003 Nov; 25(11):874-9. PMID: 14608197.
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    50. Schmugge M, Revel-Vilk S, Hiraki L, Rand ML, Blanchette VS, Silverman ED. Thrombocytopenia and thromboembolism in pediatric systemic lupus erythematosus. J Pediatr. 2003 Nov; 143(5):666-9. PMID: 14615743.
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    51. Freedman J, Rand ML, Russell O, Davis C, Cheatley PL, Blanchette V, Garvey MB. Immunoadsorption may provide a cost-effective approach to management of patients with inhibitors to FVIII. Transfusion. 2003 Nov; 43(11):1508-13. PMID: 14617307.
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    52. Israels SJ, Rand ML, Michelson AD. Neonatal platelet function. Semin Thromb Hemost. 2003 Aug; 29(4):363-72. PMID: 14517748.
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    53. Schmugge M, Rand ML, Bang KW, Mody M, Dunn MS, Amankwah KS, Blanchette VS, Freedman J. The relationship of von Willebrand factor binding to activated platelets from healthy neonates and adults. Pediatr Res. 2003 Oct; 54(4):474-9. PMID: 12815111.
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    54. Schmugge M, Rand ML, Freedman J. Platelets and von Willebrand factor. Transfus Apher Sci. 2003 Jun; 28(3):269-77. PMID: 12725954.
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    55. Rand ML, Leung R, Packham MA. Platelet function assays. Transfus Apher Sci. 2003 Jun; 28(3):307-17. PMID: 12725958.
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    56. Crow AR, Leytin V, Starkey AF, Rand ML, Lazarus AH. CD154 (CD40 ligand)-deficient mice exhibit prolonged bleeding time and decreased shear-induced platelet aggregates. J Thromb Haemost. 2003 Apr; 1(4):850-2. PMID: 12871426.
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    57. Reynaud D, Clark D, Qiao N, Rand ML, Pace-Asciak CR. The hepoxilin stable analogue, PBT-3, inhibits primary, platelet-related hemostasis in whole blood measured in vitro with the PFA-100. Thromb Res. 2003; 112(4):245-8. PMID: 14987919.
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    58. Rand ML, Jakubowski JA, Fisher MJ, Chahil A, Kinlough-Rathbone RL, Packham MA. Ethanol enhances the inhibitory effect of an oral GPIIb/IIIa antagonist on human platelet function. J Lab Clin Med. 2002 Dec; 140(6):391-7. PMID: 12486406.
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    59. Carcao MD, Blanchette VS, Stephens D, He L, Wakefield CD, Butchart S, Christie DJ, Rand ML. Assessment of thrombocytopenic disorders using the Platelet Function Analyzer (PFA-100). Br J Haematol. 2002 Jun; 117(4):961-4. PMID: 12060138.
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    60. Leytin V, Allen DJ, Mody M, Rand ML, Hannach B, Garvey B, Freedman J. A rabbit model for monitoring in vivo viability of human platelet concentrates using flow cytometry. Transfusion. 2002 Jun; 42(6):711-8. PMID: 12147023.
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    61. Rand ML, Wang H, Mody M, Chu I, Treutiger I, Nguyen A, Packham MA, Freedman J. Concurrent measurement of the survival of two populations of rabbit platelets labeled with either two PKH lipophilic dyes or two concentrations of biotin. Cytometry. 2002 Feb 01; 47(2):111-7. PMID: 11813201.
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    62. Cavic BA, Freedman J, Morel Z, Mody M, Rand ML, Stone DC, Thompson M. Blood platelet adhesion to protein studied by on-line acoustic wave sensor. Analyst. 2001 Mar; 126(3):342-8. PMID: 11284336.
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    63. Dean JA, Blanchette VS, Carcao MD, Stain AM, Sparling CR, Siekmann J, Turecek PL, Lillicrap D, Rand ML. von Willebrand disease in a pediatric-based population--comparison of type 1 diagnostic criteria and use of the PFA-100 and a von Willebrand factor/collagen-binding assay. Thromb Haemost. 2000 Sep; 84(3):401-9. PMID: 11019962.
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    64. Blanchette VS, Johnson J, Rand M. The management of alloimmune neonatal thrombocytopenia. Baillieres Best Pract Res Clin Haematol. 2000 Sep; 13(3):365-90. PMID: 11030040.
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    65. Kinlough-Rathbone RL, Perry DW, Rand ML, Packham MA. Responses to aggregating agents after cleavage of GPIb of human platelets by the O-sialoglycoprotein endoprotease from Pasteurella haemolytica- potential surrogates for Bernard-Soulier platelets? Thromb Res. 2000 Jul 15; 99(2):165-72. PMID: 10946090.
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    66. Rand ML, Packham MA, Taylor DM, Yeo EL, Gemmell CH, Patil S, Lam SC. The fibrinogen gamma chain dodecapeptide inhibits agonist-induced aggregation of rabbit platelets and fibrinogen binding to rabbit glycoprotein IIb-IIIa. Thromb Haemost. 1999 Dec; 82(6):1680-6. PMID: 10613655.
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    67. Nguyen A, Packham MA, Rand ML. Effects of ethanol on platelet responses associated with adhesion to collagen. Thromb Res. 1999 Sep 15; 95(6):303-14. PMID: 10527408.
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    68. Kinlough-Rathbone RL, Perry DW, Rand ML, Packham MA. Effects of cathepsin G pretreatment of platelets on their subsequent responses to aggregating agents. Thromb Res. 1999 Sep 15; 95(6):315-23. PMID: 10527409.
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    69. Kinlough-Rathbone RL, Perry DW, Rand ML, Packham MA. Role of secreted adenosine diphosphate in the synergistic effects of cathepsin G on human platelets. Thromb Res. 1999 Sep 15; 95(6):341-6. PMID: 10527412.
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    70. Kinlough-Rathbone RL, Perry DW, Rand ML, Packham MA. Most apyrase preparations are impure and contain inhibitors of cathepsin G: suggestions for use of apyrase in preparation and stabilization of platelet suspensions. Thromb Haemost. 1999 May; 81(5):849-50. PMID: 10365766.
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    71. Nguyen A, Gemmell CH, Yeo EL, Packham MA, Rand ML. Ethanol inhibits thrombin-induced secretion of the contents of human platelet dense and alpha-granules and lysosomes. Thromb Haemost. 1998 Oct; 80(4):662-7. PMID: 9798988.
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    72. Rand ML, Sangrar W, Hancock MA, Taylor DM, Marcovina SM, Packham MA, Koschinsky ML. Apolipoprotein(a) enhances platelet responses to the thrombin receptor-activating peptide SFLLRN. Arterioscler Thromb Vasc Biol. 1998 Sep; 18(9):1393-9. PMID: 9743227.
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    73. Rand ML, Wright JF. Virus-associated idiopathic thrombocytopenic purpura. Transfus Sci. 1998 Sep; 19(3):253-9. PMID: 10351137.
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    74. Rand ML, Dean JA. Platelet function in autoimmune (idiopathic) thrombocytopenic purpura. Acta Paediatr Suppl. 1998 Jun; 424:57-60. PMID: 9736221.
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    75. Carcao MD, Blanchette VS, Dean JA, He L, Kern MA, Stain AM, Sparling CR, Stephens D, Ryan G, Freedman J, Rand ML. The Platelet Function Analyzer (PFA-100): a novel in-vitro system for evaluation of primary haemostasis in children. Br J Haematol. 1998 Apr; 101(1):70-3. PMID: 9576184.
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    76. Rand ML, Carcao MD, Blanchette VS. Use of the PFA-100 in the assessment of primary, platelet-related hemostasis in a pediatric setting. Semin Thromb Hemost. 1998; 24(6):523-9. PMID: 10066147.
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    77. Tracy RP, Rubin DZ, Mann KG, Bovill EG, Rand M, Geffken D, Tracy PB. Thrombolytic therapy and proteolysis of factor V. J Am Coll Cardiol. 1997 Sep; 30(3):716-24. PMID: 9283531.
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    78. Kinlough-Rathbone RL, Perry DW, Rand ML, Packham MA. Pretreatment of human platelets with plasmin inhibits responses to thrombin, but potentiates responses to low concentrations of aggregating agents, including the thrombin receptor activating peptide, SFLLRN. Thromb Haemost. 1997 Apr; 77(4):741-7. PMID: 9134653.
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    79. Blanchette VS, Rand ML. Platelet disorders in newborn infants: diagnosis and management. Semin Perinatol. 1997 Feb; 21(1):53-62. PMID: 9190034.
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    80. Packham MA, Ruben DH, Rand ML. Exogenous diacylglycerols synergize with PAF with human platelets, but inhibit PAF-induced responses of rabbit platelets. J Lipid Mediat Cell Signal. 1996 Dec; 15(1):69-87. PMID: 9029375.
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    81. Rand ML, Perry DW, Packham MA, Gemmell CH, Yeo EL, Kinlough-Rathbone RL. Conditions influencing release of granule contents from human platelets in citrated plasma induced by ADP or the thrombin receptor activating peptide SFLLRN: direct measurement of percent release of beta-thromboglobulin and assessment by flow cytometry of P-selectin expression. Am J Hematol. 1996 Aug; 52(4):288-94. PMID: 8701947.
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    82. Packham MA, Rand ML, Perry DW, Ruben DH, Kinlough-Rathbone RL. Probenecid inhibits platelet responses to aggregating agents in vitro and has a synergistic inhibitory effect with penicillin G. Thromb Haemost. 1996 Aug; 76(2):239-44. PMID: 8865538.
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    83. Rand ML, DaCosta SM, Chahil A, Kinlough-Rathbone RL. Combined inhibitory effects of ethanol and adenosine on the responses of rabbit platelets to thrombin. Alcohol Clin Exp Res. 1995 Oct; 19(5):1279-85. PMID: 8561302.
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    84. Latta EK, Packham MA, DaCosta SM, Rand ML. Effects of chronic administration of ethanol on platelets from rabbits with diet-induced hypercholesterolemia. Unchanged characteristics and responses to ADP but reduction of enhanced thrombin-induced, TxA2-independent platelet responses. Arterioscler Thromb. 1994 Aug; 14(8):1372-7. PMID: 8049200.
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    85. Latta EK, Packham MA, Gross PL, Rand ML. Enhanced collagen-induced responses of platelets from rabbits with diet-induced hypercholesterolemia are due to increased sensitivity to TxA2. Response inhibition by chronic ethanol administration in hypercholesterolemia is due to reduced TxA2 formation. Arterioscler Thromb. 1994 Aug; 14(8):1379-85. PMID: 8049201.
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    86. Whitman SC, Fish JR, Rand ML, Rogers KA. n-3 fatty acid incorporation into LDL particles renders them more susceptible to oxidation in vitro but not necessarily more atherogenic in vivo. Arterioscler Thromb. 1994 Jul; 14(7):1170-6. PMID: 8018674.
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    87. Rubin R, Rand ML. Alcohol and platelet function. Alcohol Clin Exp Res. 1994 Feb; 18(1):105-10. PMID: 8198204.
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    88. Kinlough-Rathbone RL, Perry DW, Guccione MA, Rand ML, Packham MA. Degranulation of human platelets by the thrombin receptor peptide SFLLRN: comparison with degranulation by thrombin. Thromb Haemost. 1993 Dec 20; 70(6):1019-23. PMID: 8165594.
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    89. Kinlough-Rathbone RL, Rand ML, Packham MA. Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets. Blood. 1993 Jul 01; 82(1):103-6. PMID: 8391870.
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    90. Packham MA, Livne AA, Ruben DH, Rand ML. Activation of phospholipase C and protein kinase C has little involvement in ADP-induced primary aggregation of human platelets: effects of diacylglycerols, the diacylglycerols, the diacylglycerol kinase inhibitor R59022, staurosporine and okadaic acid. Biochem J. 1993 Mar 15; 290 ( Pt 3):849-56. PMID: 8384448.
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    91. Packham MA, Rand ML, Kinlough-Rathbone RL. Similarities and differences between rabbit and human platelet characteristics and functions. Comp Biochem Physiol Comp Physiol. 1992 Sep; 103(1):35-54. PMID: 1356699.
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    92. Rand ML, Gross PL, Barrow DV, Packham MA. Acute in vitro effects of ethanol on responses of platelets from cholesterol-fed and Watanabe heritable hyperlipidemic rabbits. Arterioscler Thromb. 1992 Apr; 12(4):437-45. PMID: 1558835.
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    93. Gross PL, Rand ML, Barrow DV, Packham MA. Platelet hypersensitivity in cholesterol-fed rabbits: enhancement of thromboxane A2-dependent and thrombin-induced, thromboxane A2-independent platelet responses. Atherosclerosis. 1991 May; 88(1):77-86. PMID: 1878012.
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    94. Gross PL, Rand ML, Barrow DV, Packham MA. Platelet function in Watanabe heritable hyperlipidemic rabbits. Decreased sensitivity to thromboxane A2. Arterioscler Thromb. 1991 May-Jun; 11(3):610-6. PMID: 2029501.
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    95. Rand ML, Groves HM, Packham MA, Mustard JF, Kinlough-Rathbone RL. Inhibition by ethanol of thrombus formation induced by indwelling aortic catheters in rabbits. Thromb Haemost. 1991 Apr 08; 65(4):454-5. PMID: 2057931.
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    96. Packham MA, Rand ML, Ruben DH, Kinlough-Rathbone RL. Effect of calcium concentration and inhibitors on the responses of platelets stimulated with collagen: contrast between human and rabbit platelets. Comp Biochem Physiol A Comp Physiol. 1991; 99(4):551-7. PMID: 1679691.
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    97. Rand ML, Groves HM, Packham MA, Mustard JF, Kinlough-Rathbone RL. Acute administration of ethanol to rabbits inhibits thrombus formation induced by indwelling aortic catheters. Lab Invest. 1990 Dec; 63(6):742-5. PMID: 2255182.
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    98. Rand ML, Neiman J, Jakowec DM, Packham MA. Effects of alcohol withdrawal on responses of platelets from alcoholics--a study using platelet-rich plasma from blood anticoagulated with D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone (FPRCH2Cl). Thromb Haemost. 1990 Apr 12; 63(2):178-82. PMID: 2363118.
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    99. Winocour PD, Bryszewska M, Watala C, Rand ML, Epand RM, Kinlough-Rathbone RL, Packham MA, Mustard JF. Reduced membrane fluidity in platelets from diabetic patients. Diabetes. 1990 Feb; 39(2):241-4. PMID: 2227132.
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    100. Neiman J, Rand ML, Jakowec DM, Packham MA. Platelet responses to platelet-activating factor are inhibited in alcoholics undergoing alcohol withdrawal. Thromb Res. 1989 Nov 01; 56(3):399-405. PMID: 2617478.
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    101. Rand ML, Gross PL, Jakowec DM, Packham MA, Mustard JF. In vitro effects of ethanol on rabbit platelet aggregation, secretion of granule contents, and cyclic AMP levels in the presence of prostacyclin. Thromb Haemost. 1989 Apr 25; 61(2):254-8. PMID: 2546284.
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    102. Winocour PD, Rand ML, Kinlough-Rathbone RL, Richardson M, Mustard JF. Platelet function and survival in rats with genetically determined hypercholesterolaemia. Atherosclerosis. 1989 Mar; 76(1):63-70. PMID: 2920065.
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    103. Rand ML, Hennissen AA, Hornstra G. Effects of dietary palm oil on arterial thrombosis, platelet responses and platelet membrane fluidity in rats. Lipids. 1988 Nov; 23(11):1019-23. PMID: 3237001.
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    104. Winocour PD, Kinlough-Rathbone RL, Rand ML, Hatton MW, Mustard JF. Thrombin binding to platelets from hypercholesterolaemic rats. Atherosclerosis. 1988 Oct; 73(2-3):215-21. PMID: 3190819.
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    105. Rand ML, Packham MA, Kinlough-Rathbone RL, Fraser Mustard J. Effects of ethanol on pathways of platelet aggregation in vitro. Thromb Haemost. 1988 Jun 16; 59(3):383-7. PMID: 3142075.
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    106. Rand ML, Vickers JD, Kinlough-Rathbone RL, Packham MA, Mustard JF. Thrombin-induced inositol trisphosphate production by rabbit platelets is inhibited by ethanol. Biochem J. 1988 Apr 01; 251(1):279-84. PMID: 3260489.
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    107. Rand ML, Groves HM, Kinlough-Rathbone RL, Packham MA, Mustard JF. Effects of ethanol on rabbit platelet responses to collagen in vitro and ex vivo and on platelet adhesion to de-endothelialized aortae in vivo. Thromb Res. 1987 Nov 01; 48(3):379-88. PMID: 3433259.
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    108. Rand ML, Hennissen AA, Hornstra G. Effects of dietary sunflowerseed oil and marine oil on platelet membrane fluidity, arterial thrombosis, and platelet responses in rats. Atherosclerosis. 1986 Dec; 62(3):267-76. PMID: 3801090.
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    109. van Dam-Mieras MC, Muller AD, Rand ML, Hornstra G. Dietary lipids and macrophage procoagulant activity. Thromb Res. 1986 Jul 01; 43(1):133-7. PMID: 3726809.
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    110. Packham MA, Perry DW, Kinlough-Rathbone RL, Rand ML, Guccione MA, Evans RM, Mustard JF. Effects on the buoyant density of rabbit platelets of ADP and agents that increase the concentration of cyclic AMP. Blood. 1985 Mar; 65(3):564-70. PMID: 2982440.
      View in: PubMed
    111. Guccione MA, Kinlough-Rathbone RL, Packham MA, Harfenist EJ, Rand ML, Greenberg JP, Perry DW, Mustard JF. Effects of plasmin on rabbit platelets. Thromb Haemost. 1985 Feb 18; 53(1):8-14. PMID: 3158094.
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    112. Rand ML, Packham MA, Mustard JF. Survival of density subpopulations of rabbit platelets: use of 51Cr-or 111In-labeled platelets to measure survival of least dense and most dense platelets concurrently. Blood. 1983 Feb; 61(2):362-7. PMID: 6821702.
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    113. Winocour PD, Kinlough-Rathbone RL, Perry DW, Rand ML, Packham MA, Mustard JF. Changes in the properties of platelets from rats with experimentally induced shortened platelet survival. J Lab Clin Med. 1983 Feb; 101(2):175-82. PMID: 6822757.
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    114. Rand ML, Greenberg JP, Packham MA, Mustard JF. Density subpopulations of rabbit platelets: size, protein, and sialic acid content, and specific radioactivity changes following labeling with 35S-sulfate in vivo. Blood. 1981 Apr; 57(4):741-6. PMID: 7470624.
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    115. Greenberg JP, Packham MA, Guccione MA, Rand ML, Reimers HJ, Mustard JF. Survival of rabbit platelets treated in vitro with chymotrypsin, plasmin, trypsin, or neuraminidase. Blood. 1979 May; 53(5):916-27. PMID: 155482.
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    116. Cieslar P, Greenberg JP, Rand ML, Packham MA, Kinlough-Rathbone RL, Mustard JF. Separation of thrombin-treated platelets from normal platelets by density-gradient centrifugation. Blood. 1979 May; 53(5):867-74. PMID: 435644.
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    117. RAND M, STAFFORD A. The duration of action of some cardiac glycosides and aglycones in the guinea-pig. Br J Pharmacol Chemother. 1959 Jun; 14(2):174-8. PMID: 13662569.
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    118. RAND M, STAFFORD A. Effect of the rate of elimination of digoxigenin in the guinea pig on the determination of its lethal dose. Nature. 1959 Mar 07; 183(4662):688-9. PMID: 13632839.
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    119. RAND M, STAFFORD A. The influence of ouabain on the response of the guineapig heart to acetylcholine, adenosine and vagal stimulation. Arch Int Pharmacodyn Ther. 1957 Feb 01; 109(3-4):425-38. PMID: 13425733.
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    120. RAND M, STAFFORD A. A method for determining the duration of action of the cardiac glycosides. Nature. 1956 Feb 11; 177(4502):278-9. PMID: 13297024.
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    121. STAFFORD A, RAND M. Cardiac actions of coenzyme I. I. Actions on the guinea-pig and rat heart in situ and on the isolated guinea-pig heart. Aust J Exp Biol Med Sci. 1955 Dec; 33(6):651-6. PMID: 13315143.
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    122. STAFFORD A, RAND M. Cardiac actions of coenzyme I. II. Factors affecting the response of the guinea-pig heart to coenzyme I. Aust J Exp Biol Med Sci. 1955 Dec; 33(6):657-61. PMID: 13315144.
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    123. RAND M, STAFFORD A, THORP RH. The effect of cardiac glycosides on the heart block produced in the guinea-pig by adenosine and its derivatives. Aust J Exp Biol Med Sci. 1955 Dec; 33(6):663-9. PMID: 13315145.
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    124. RAND M, STAFFORD A, THORP RH. The potentiation of the action of adenosine on the guinea pig heart by ouabain. J Pharmacol Exp Ther. 1955 May; 114(1):119-25. PMID: 14392579.
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