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William Trimble

TitleProgram Head, Senior Scientist
InstitutionThe Hospital for Sick Children
DepartmentCell Biology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
ORCID ORCID Icon0000-0001-9776-5111 Additional info
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    Collapse Biography 
    Collapse education and training
    University of Toronto, Toronto, CanadaB.Sc.05/1981Microbiology
    University of Toronto, Toronto, CanadaPh.D.03/1987Cancer biology
    Stanford University, Palo Alto, CaliforniaPost-doc09/1990Molecular neuroscience
    Collapse awards and honors
    2000 - 2005Investigator, CIHR
    2005 - presChair in Molecular Cell Biology, Canada Research Chairs
    2006 - presFellow, Royal Society of Canada

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Marques PE, Nyegaard S, Collins RF, Troise F, Freeman SA, Trimble WS, Grinstein S. Multimerization and Retention of the Scavenger Receptor SR-B1 in the Plasma Membrane. Dev Cell. 2019 Jun 04. PMID: 31231038.
      View in: PubMed
    2. Vissa A, Giuliani M, Froese CD, Kim MS, Soroor F, Kim PK, Trimble WS, Yip CM. Single-molecule localization microscopy of septin bundles in mammalian cells. Cytoskeleton (Hoboken). 2019 Jan; 76(1):63-72. PMID: 30176126.
      View in: PubMed
    3. Boddy KC, Gao AD, Truong D, Kim MS, Froese CD, Trimble WS, Brumell JH. Septin-regulated actin dynamics promote Salmonella invasion of host cells. Cell Microbiol. 2018 10; 20(10):e12866. PMID: 29885024.
      View in: PubMed
    4. Liu S, Ginzberg MB, Patel N, Hild M, Leung B, Li Z, Chen YC, Chang N, Wang Y, Tan C, Diena S, Trimble W, Wasserman L, Jenkins JL, Kirschner MW, Kafri R. Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length. Elife. 2018 03 29; 7. PMID: 29595474.
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    5. Stefan CJ, Trimble WS, Grinstein S, Drin G, Reinisch K, De Camilli P, Cohen S, Valm AM, Lippincott-Schwartz J, Levine TP, Iaea DB, Maxfield FR, Futter CE, Eden ER, Judith D, van Vliet AR, Agostinis P, Tooze SA, Sugiura A, McBride HM. Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers. BMC Biol. 2017 10 31; 15(1):102. PMID: 29089042.
      View in: PubMed
    6. Palander O, El-Zeiry M, Trimble WS. Uncovering the Roles of Septins in Cilia. Front Cell Dev Biol. 2017; 5:36. PMID: 28428954.
      View in: PubMed
    7. Hua R, Cheng D, Coyaud É, Freeman S, Di Pietro E, Wang Y, Vissa A, Yip CM, Fairn GD, Braverman N, Brumell JH, Trimble WS, Raught B, Kim PK. VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis. J Cell Biol. 2017 02; 216(2):367-377. PMID: 28108526.
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    8. Howard JC, Florentinus-Mefailoski A, Bowden P, Trimble W, Grinstein S, Marshall JG. OxLDL receptor chromatography from live human U937 cells identifies SYK(L) that regulates phagocytosis of oxLDL. Anal Biochem. 2016 11 15; 513:7-20. PMID: 27510553.
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    9. Kim MS, Froese CD, Xie H, Trimble WS. Immunofluorescent staining of septins in primary cilia. Methods Cell Biol. 2016; 136:269-83. PMID: 27473914.
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    10. Vance DT, Dufresne J, Florentinus-Mefailoski A, Tucholska M, Trimble W, Grinstein S, Marshall JG. A phagocytosis assay for oxidized low-density lipoprotein versus immunoglobulin G-coated microbeads in human U937 macrophages. Anal Biochem. 2016 May 01; 500:24-34. PMID: 26800863.
      View in: PubMed
    11. Scholz R, Imami K, Scott NE, Trimble WS, Foster LJ, Finlay BB. Novel Host Proteins and Signaling Pathways in Enteropathogenic E. coli Pathogenesis Identified by Global Phosphoproteome Analysis. Mol Cell Proteomics. 2015 Jul; 14(7):1927-45. PMID: 25944883.
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    12. Trimble WS, Grinstein S. Barriers to the free diffusion of proteins and lipids in the plasma membrane. J Cell Biol. 2015 Feb 02; 208(3):259-71. PMID: 25646084.
      View in: PubMed
    13. Pham T, DiCiccio JE, Trimble WS. Cytoskeleton: septins do the horizontal tango. Curr Biol. 2014 Apr 14; 24(8):R324-7. PMID: 24735857.
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    14. Lee AY, St Onge RP, Proctor MJ, Wallace IM, Nile AH, Spagnuolo PA, Jitkova Y, Gronda M, Wu Y, Kim MK, Cheung-Ong K, Torres NP, Spear ED, Han MK, Schlecht U, Suresh S, Duby G, Heisler LE, Surendra A, Fung E, Urbanus ML, Gebbia M, Lissina E, Miranda M, Chiang JH, Aparicio AM, Zeghouf M, Davis RW, Cherfils J, Boutry M, Kaiser CA, Cummins CL, Trimble WS, Brown GW, Schimmer AD, Bankaitis VA, Nislow C, Bader GD, Giaever G. Mapping the cellular response to small molecules using chemogenomic fitness signatures. Science. 2014 Apr 11; 344(6180):208-11. PMID: 24723613.
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    15. Xu H, Mohtashami M, Stewart B, Boulianne G, Trimble WS. Drosophila SNAP-29 is an essential SNARE that binds multiple proteins involved in membrane traffic. PLoS One. 2014; 9(3):e91471. PMID: 24626111.
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    16. Mostowy S, Bi E, Füchtbauer EM, Goryachev AB, Montagna C, Nagata K, Trimble WS, Werner HB, Yao X, Zieger B, Spiliotis ET. Highlight: the 5th International Workshop on Septin Biology. Biol Chem. 2014 Feb; 395(2):119-21. PMID: 24334412.
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    17. Fung KY, Dai L, Trimble WS. Cell and molecular biology of septins. Int Rev Cell Mol Biol. 2014; 310:289-339. PMID: 24725429.
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    18. Neculai D, Schwake M, Ravichandran M, Zunke F, Collins RF, Peters J, Neculai M, Plumb J, Loppnau P, Pizarro JC, Seitova A, Trimble WS, Saftig P, Grinstein S, Dhe-Paganon S. Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Nature. 2013 Dec 05; 504(7478):172-6. PMID: 24162852.
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    19. Pocanschi CL, Ehsani S, Mehrabian M, Wille H, Reginold W, Trimble WS, Wang H, Yee A, Arrowsmith CH, Bozóky Z, Kay LE, Forman-Kay JD, Rini JM, Schmitt-Ulms G. The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer. PLoS One. 2013; 8(9):e72446. PMID: 24039764.
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    20. Estey MP, Di Ciano-Oliveira C, Froese CD, Fung KY, Steels JD, Litchfield DW, Trimble WS. Mitotic regulation of SEPT9 protein by cyclin-dependent kinase 1 (Cdk1) and Pin1 protein is important for the completion of cytokinesis. J Biol Chem. 2013 Oct 18; 288(42):30075-86. PMID: 23990466.
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    21. Heit B, Kim H, Cosío G, Castaño D, Collins R, Lowell CA, Kain KC, Trimble WS, Grinstein S. Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Dev Cell. 2013 Feb 25; 24(4):372-83. PMID: 23395392.
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    22. Kim MS, Froese CD, Xie H, Trimble WS. Uncovering principles that control septin-septin interactions. J Biol Chem. 2012 Aug 31; 287(36):30406-13. PMID: 22815479.
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    23. Ehsani S, Salehzadeh A, Huo H, Reginold W, Pocanschi CL, Ren H, Wang H, So K, Sato C, Mehrabian M, Strome R, Trimble WS, Hazrati LN, Rogaeva E, Westaway D, Carlson GA, Schmitt-Ulms G. LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation. J Mol Biol. 2012 Sep 28; 422(4):556-574. PMID: 22687393.
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    24. Harper KM, Hiramoto T, Tanigaki K, Kang G, Suzuki G, Trimble W, Hiroi N. Alterations of social interaction through genetic and environmental manipulation of the 22q11.2 gene Sept5 in the mouse brain. Hum Mol Genet. 2012 Aug 01; 21(15):3489-99. PMID: 22589251.
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    25. Yoshida A, Yamamoto N, Kinoshita M, Hiroi N, Hiramoto T, Kang G, Trimble WS, Tanigaki K, Nakagawa T, Ito J. Localization of septin proteins in the mouse cochlea. Hear Res. 2012 Jul; 289(1-2):40-51. PMID: 22575789.
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    26. Willetts A, Joint I, Gilbert JA, Trimble W, Mühling M. Isolation and initial characterization of a novel type of Baeyer-Villiger monooxygenase activity from a marine microorganism. Microb Biotechnol. 2012 Jul; 5(4):549-59. PMID: 22414193.
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    27. Beise N, Trimble W. Septins at a glance. J Cell Sci. 2011 Dec 15; 124(Pt 24):4141-6. PMID: 22247190.
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    28. Kim MS, Froese CD, Estey MP, Trimble WS. SEPT9 occupies the terminal positions in septin octamers and mediates polymerization-dependent functions in abscission. J Cell Biol. 2011 Nov 28; 195(5):815-26. PMID: 22123865.
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    29. Jaqaman K, Kuwata H, Touret N, Collins R, Trimble WS, Danuser G, Grinstein S. Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function. Cell. 2011 Aug 19; 146(4):593-606. PMID: 21854984.
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    30. Tsang CW, Estey MP, DiCiccio JE, Xie H, Patterson D, Trimble WS. Characterization of presynaptic septin complexes in mammalian hippocampal neurons. Biol Chem. 2011 Aug; 392(8-9):739-49. PMID: 21767234.
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    31. Estey MP, Kim MS, Trimble WS. Septins. Curr Biol. 2011 May 24; 21(10):R384-7. PMID: 21601794.
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    32. Estey MP, Di Ciano-Oliveira C, Froese CD, Bejide MT, Trimble WS. Distinct roles of septins in cytokinesis: SEPT9 mediates midbody abscission. J Cell Biol. 2010 Nov 15; 191(4):741-9. PMID: 21059847.
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    33. Yang YM, Fedchyshyn MJ, Grande G, Aitoubah J, Tsang CW, Xie H, Ackerley CA, Trimble WS, Wang LY. Septins regulate developmental switching from microdomain to nanodomain coupling of Ca(2+) influx to neurotransmitter release at a central synapse. Neuron. 2010 Jul 15; 67(1):100-15. PMID: 20624595.
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    34. Richier L, Williton K, Clattenburg L, Colwill K, O'Brien M, Tsang C, Kolar A, Zinck N, Metalnikov P, Trimble WS, Krueger SR, Pawson T, Fawcett JP. NOS1AP associates with Scribble and regulates dendritic spine development. J Neurosci. 2010 Mar 31; 30(13):4796-805. PMID: 20357130.
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    35. Goldbach P, Wong R, Beise N, Sarpal R, Trimble WS, Brill JA. Stabilization of the actomyosin ring enables spermatocyte cytokinesis in Drosophila. Mol Biol Cell. 2010 May 01; 21(9):1482-93. PMID: 20237160.
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    36. Collins RF, Touret N, Kuwata H, Tandon NN, Grinstein S, Trimble WS. Uptake of oxidized low density lipoprotein by CD36 occurs by an actin-dependent pathway distinct from macropinocytosis. J Biol Chem. 2009 Oct 30; 284(44):30288-97. PMID: 19740737.
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    37. Suzuki G, Harper KM, Hiramoto T, Sawamura T, Lee M, Kang G, Tanigaki K, Buell M, Geyer MA, Trimble WS, Agatsuma S, Hiroi N. Sept5 deficiency exerts pleiotropic influence on affective behaviors and cognitive functions in mice. Hum Mol Genet. 2009 May 01; 18(9):1652-60. PMID: 19240081.
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    38. Tooley AJ, Gilden J, Jacobelli J, Beemiller P, Trimble WS, Kinoshita M, Krummel MF. Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility. Nat Cell Biol. 2009 Jan; 11(1):17-26. PMID: 19043408.
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    39. Tsang CW, Fedchyshyn M, Harrison J, Xie H, Xue J, Robinson PJ, Wang LY, Trimble WS. Superfluous role of mammalian septins 3 and 5 in neuronal development and synaptic transmission. Mol Cell Biol. 2008 Dec; 28(23):7012-29. PMID: 18809578.
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    40. Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH. Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication. Infect Immun. 2008 Jun; 76(6):2722-35. PMID: 18411289.
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    41. Huang YW, Yan M, Collins RF, Diciccio JE, Grinstein S, Trimble WS. Mammalian septins are required for phagosome formation. Mol Biol Cell. 2008 Apr; 19(4):1717-26. PMID: 18272790.
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    42. Joo E, Surka MC, Trimble WS. Mammalian SEPT2 is required for scaffolding nonmuscle myosin II and its kinases. Dev Cell. 2007 Nov; 13(5):677-90. PMID: 17981136.
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    43. Peterson EA, Kalikin LM, Steels JD, Estey MP, Trimble WS, Petty EM. Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin. Mamm Genome. 2007 Nov; 18(11):796-807. PMID: 17922164.
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    44. Steels JD, Estey MP, Froese CD, Reynaud D, Pace-Asciak C, Trimble WS. Sept12 is a component of the mammalian sperm tail annulus. Cell Motil Cytoskeleton. 2007 Oct; 64(10):794-807. PMID: 17685441.
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    45. Trimble WS, Grinstein S. TB or not TB: calcium regulation in mycobacterial survival. Cell. 2007 Jul 13; 130(1):12-4. PMID: 17632049.
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    46. Yan M, Di Ciano-Oliveira C, Grinstein S, Trimble WS. Coronin function is required for chemotaxis and phagocytosis in human neutrophils. J Immunol. 2007 May 01; 178(9):5769-78. PMID: 17442961.
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    47. Steels JD, Trimble WS. Resolving polarized views: septin filaments do the twist. Dev Cell. 2006 Nov; 11(5):591-2. PMID: 17084349.
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    48. Huang YW, Surka MC, Reynaud D, Pace-Asciak C, Trimble WS. GTP binding and hydrolysis kinetics of human septin 2. FEBS J. 2006 Jul; 273(14):3248-60. PMID: 16857012.
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    49. Craven RA, Hanrahan S, Totty N, Harnden P, Stanley AJ, Maher ER, Harris AL, Trimble WS, Selby PJ, Banks RE. Proteomic identification of a role for the von Hippel Lindau tumour suppressor in changes in the expression of mitochondrial proteins and septin 2 in renal cell carcinoma. Proteomics. 2006 Jul; 6(13):3880-93. PMID: 16739133.
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    50. Ahuja P, Perriard E, Trimble W, Perriard JC, Ehler E. Probing the role of septins in cardiomyocytes. Exp Cell Res. 2006 May 15; 312(9):1598-609. PMID: 16739252.
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    51. Joo E, Tsang CW, Trimble WS. Septins: traffic control at the cytokinesis intersection. Traffic. 2005 Aug; 6(8):626-34. PMID: 15998319.
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    52. Yan M, Collins RF, Grinstein S, Trimble WS. Coronin-1 function is required for phagosome formation. Mol Biol Cell. 2005 Jul; 16(7):3077-87. PMID: 15829569.
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    53. Beites CL, Campbell KA, Trimble WS. The septin Sept5/CDCrel-1 competes with alpha-SNAP for binding to the SNARE complex. Biochem J. 2005 Jan 15; 385(Pt 2):347-53. PMID: 15355307.
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    54. Xue J, Tsang CW, Gai WP, Malladi CS, Trimble WS, Rostas JA, Robinson PJ. Septin 3 (G-septin) is a developmentally regulated phosphoprotein enriched in presynaptic nerve terminals. J Neurochem. 2004 Nov; 91(3):579-90. PMID: 15485489.
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    55. Huynh H, Bottini N, Williams S, Cherepanov V, Musumeci L, Saito K, Bruckner S, Vachon E, Wang X, Kruger J, Chow CW, Pellecchia M, Monosov E, Greer PA, Trimble W, Downey GP, Mustelin T. Control of vesicle fusion by a tyrosine phosphatase. Nat Cell Biol. 2004 Sep; 6(9):831-9. PMID: 15322554.
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    56. Barr AM, Young CE, Sawada K, Trimble WS, Phillips AG, Honer WG. Abnormalities of presynaptic protein CDCrel-1 in striatum of rats reared in social isolation: relevance to neural connectivity in schizophrenia. Eur J Neurosci. 2004 Jul; 20(1):303-7. PMID: 15245502.
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    57. She YM, Huang YW, Zhang L, Trimble WS. Septin 2 phosphorylation: theoretical and mass spectrometric evidence for the existence of a single phosphorylation site in vivo. Rapid Commun Mass Spectrom. 2004; 18(10):1123-30. PMID: 15150837.
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    58. Scott CC, Furuya W, Trimble WS, Grinstein S. Activation of store-operated calcium channels: assessment of the role of snare-mediated vesicular transport. J Biol Chem. 2003 Aug 15; 278(33):30534-9. PMID: 12764154.
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    59. Vieira OV, Bucci C, Harrison RE, Trimble WS, Lanzetti L, Gruenberg J, Schreiber AD, Stahl PD, Grinstein S. Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase. Mol Cell Biol. 2003 Apr; 23(7):2501-14. PMID: 12640132.
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    60. Chung I, Burkart A, Szmydynger-Chodobska J, Dodd KA, Trimble WS, Miller KV, Shim M, Chodobski A. Expression of two membrane fusion proteins, synaptosome-associated protein of 25 kDa and vesicle-associated membrane protein, in choroid plexus epithelium. Neuroscience. 2003; 116(2):349-57. PMID: 12559091.
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    61. Xu H, Boulianne GL, Trimble WS. Drosophila syntaxin 16 is a Q-SNARE implicated in Golgi dynamics. J Cell Sci. 2002 Dec 01; 115(Pt 23):4447-55. PMID: 12414991.
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    62. Macara IG, Baldarelli R, Field CM, Glotzer M, Hayashi Y, Hsu SC, Kennedy MB, Kinoshita M, Longtine M, Low C, Maltais LJ, McKenzie L, Mitchison TJ, Nishikawa T, Noda M, Petty EM, Peifer M, Pringle JR, Robinson PJ, Roth D, Russell SE, Stuhlmann H, Tanaka M, Tanaka T, Trimble WS, Ware J, Zeleznik-Le NJ, Zieger B. Mammalian septins nomenclature. Mol Biol Cell. 2002 Dec; 13(12):4111-3. PMID: 12475938.
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    63. Xu H, Brill JA, Hsien J, McBride R, Boulianne GL, Trimble WS. Syntaxin 5 is required for cytokinesis and spermatid differentiation in Drosophila. Dev Biol. 2002 Nov 15; 251(2):294-306. PMID: 12435359.
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    64. Terebiznik MR, Vieira OV, Marcus SL, Slade A, Yip CM, Trimble WS, Meyer T, Finlay BB, Grinstein S. Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella. Nat Cell Biol. 2002 Oct; 4(10):766-73. PMID: 12360287.
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    65. Surka MC, Tsang CW, Trimble WS. The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis. Mol Biol Cell. 2002 Oct; 13(10):3532-45. PMID: 12388755.
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    66. Collins RF, Schreiber AD, Grinstein S, Trimble WS. Syntaxins 13 and 7 function at distinct steps during phagocytosis. J Immunol. 2002 Sep 15; 169(6):3250-6. PMID: 12218144.
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    67. Coppolino MG, Dierckman R, Loijens J, Collins RF, Pouladi M, Jongstra-Bilen J, Schreiber AD, Trimble WS, Anderson R, Grinstein S. Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis. J Biol Chem. 2002 Nov 15; 277(46):43849-57. PMID: 12223494.
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    68. Stewart BA, Mohtashami M, Rivlin P, Deitcher DL, Trimble WS, Boulianne GL. Dominant-negative NSF2 disrupts the structure and function of Drosophila neuromuscular synapses. J Neurobiol. 2002 Jun 15; 51(4):261-71. PMID: 12150502.
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    69. Sakai K, Kurimoto M, Tsugu A, Hubbard SL, Trimble WS, Rutka JT. Expression of Nedd5, a mammalian septin, in human brain tumors. J Neurooncol. 2002 May; 57(3):169-77. PMID: 12125979.
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    70. Xu H, Boulianne GL, Trimble WS. Membrane trafficking in cytokinesis. Semin Cell Dev Biol. 2002 Apr; 13(2):77-82. PMID: 12127139.
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    71. Honer WG, Falkai P, Bayer TA, Xie J, Hu L, Li HY, Arango V, Mann JJ, Dwork AJ, Trimble WS. Abnormalities of SNARE mechanism proteins in anterior frontal cortex in severe mental illness. Cereb Cortex. 2002 Apr; 12(4):349-56. PMID: 11884350.
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    72. Ji J, Tsuk S, Salapatek AM, Huang X, Chikvashvili D, Pasyk EA, Kang Y, Sheu L, Tsushima R, Diamant N, Trimble WS, Lotan I, Gaisano HY. The 25-kDa synaptosome-associated protein (SNAP-25) binds and inhibits delayed rectifier potassium channels in secretory cells. J Biol Chem. 2002 Jun 07; 277(23):20195-204. PMID: 11925439.
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    73. Dent J, Kato K, Peng XR, Martinez C, Cattaneo M, Poujol C, Nurden P, Nurden A, Trimble WS, Ware J. A prototypic platelet septin and its participation in secretion. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):3064-9. PMID: 11880646.
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    74. Peng XR, Jia Z, Zhang Y, Ware J, Trimble WS. The septin CDCrel-1 is dispensable for normal development and neurotransmitter release. Mol Cell Biol. 2002 Jan; 22(1):378-87. PMID: 11739749.
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    75. Booth JW, Trimble WS, Grinstein S. Membrane dynamics in phagocytosis. Semin Immunol. 2001 Dec; 13(6):357-64. PMID: 11708891.
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    76. Gaisano HY, Lutz MP, Leser J, Sheu L, Lynch G, Tang L, Tamori Y, Trimble WS, Salapatek AM. Supramaximal cholecystokinin displaces Munc18c from the pancreatic acinar basal surface, redirecting apical exocytosis to the basal membrane. J Clin Invest. 2001 Dec; 108(11):1597-611. PMID: 11733555.
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    77. Coppolino MG, Krause M, Hagendorff P, Monner DA, Trimble W, Grinstein S, Wehland J, Sechi AS. Evidence for a molecular complex consisting of Fyb/SLAP, SLP-76, Nck, VASP and WASP that links the actin cytoskeleton to Fcgamma receptor signalling during phagocytosis. J Cell Sci. 2001 Dec; 114(Pt 23):4307-18. PMID: 11739662.
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    78. Huang X, Kang YH, Pasyk EA, Sheu L, Wheeler MB, Trimble WS, Salapatek A, Gaisano HY. Ca(2+) influx and cAMP elevation overcame botulinum toxin A but not tetanus toxin inhibition of insulin exocytosis. Am J Physiol Cell Physiol. 2001 Sep; 281(3):C740-50. PMID: 11502551.
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    79. Weir ML, Xie H, Klip A, Trimble WS. VAP-A binds promiscuously to both v- and tSNAREs. Biochem Biophys Res Commun. 2001 Aug 24; 286(3):616-21. PMID: 11511104.
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    80. Huang X, Sheu L, Tamori Y, Trimble WS, Gaisano HY. Cholecystokinin-regulated exocytosis in rat pancreatic acinar cells is inhibited by a C-terminus truncated mutant of SNAP-23. Pancreas. 2001 Aug; 23(2):125-33. PMID: 11484914.
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    81. Stewart BA, Mohtashami M, Zhou L, Trimble WS, Boulianne GL. SNARE-dependent signaling at the Drosophila wing margin. Dev Biol. 2001 Jun 01; 234(1):13-23. PMID: 11356016.
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    82. Mohtashami M, Stewart BA, Boulianne GL, Trimble WS. Analysis of the mutant Drosophila N-ethylmaleimide sensitive fusion-1 protein in comatose reveals molecular correlates of the behavioural paralysis. J Neurochem. 2001 Jun; 77(5):1407-17. PMID: 11389191.
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    83. Lu W, Man H, Ju W, Trimble WS, MacDonald JF, Wang YT. Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons. Neuron. 2001 Jan; 29(1):243-54. PMID: 11182095.
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    84. Beites CL, Peng XR, Trimble WS. Expression and analysis of properties of septin CDCrel-1 in exocytosis. Methods Enzymol. 2001; 329:499-510. PMID: 11210570.
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    85. Stewart BA, Mohtashami M, Trimble WS, Boulianne GL. SNARE proteins contribute to calcium cooperativity of synaptic transmission. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13955-60. PMID: 11095753.
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    86. Coppolino MG, Kong C, Mohtashami M, Schreiber AD, Brumell JH, Finlay BB, Grinstein S, Trimble WS. Requirement for N-ethylmaleimide-sensitive factor activity at different stages of bacterial invasion and phagocytosis. J Biol Chem. 2001 Feb 16; 276(7):4772-80. PMID: 11092884.
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    87. Randhawa VK, Bilan PJ, Khayat ZA, Daneman N, Liu Z, Ramlal T, Volchuk A, Peng XR, Coppola T, Regazzi R, Trimble WS, Klip A. VAMP2, but not VAMP3/cellubrevin, mediates insulin-dependent incorporation of GLUT4 into the plasma membrane of L6 myoblasts. Mol Biol Cell. 2000 Jul; 11(7):2403-17. PMID: 10888677.
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    88. Foster LJ, Weir ML, Lim DY, Liu Z, Trimble WS, Klip A. A functional role for VAP-33 in insulin-stimulated GLUT4 traffic. Traffic. 2000 Jun; 1(6):512-21. PMID: 11208137.
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    89. Bajno L, Peng XR, Schreiber AD, Moore HP, Trimble WS, Grinstein S. Focal exocytosis of VAMP3-containing vesicles at sites of phagosome formation. J Cell Biol. 2000 May 01; 149(3):697-706. PMID: 10791982.
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    90. Kim PK, Hollerbach C, Trimble WS, Leber B, Andrews DW. Identification of the endoplasmic reticulum targeting signal in vesicle-associated membrane proteins. J Biol Chem. 1999 Dec 24; 274(52):36876-82. PMID: 10601239.
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    91. Zhang J, Kong C, Xie H, McPherson PS, Grinstein S, Trimble WS. Phosphatidylinositol polyphosphate binding to the mammalian septin H5 is modulated by GTP. Curr Biol. 1999 Dec 16-30; 9(24):1458-67. PMID: 10607590.
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    92. Gaisano HY, Huang X, Sheu L, Ghai M, Newgard CB, Trinh KY, Trimble WS. Snare protein expression and adenoviral transfection of amphicrine AR42J. Biochem Biophys Res Commun. 1999 Jul 14; 260(3):781-4. PMID: 10403842.
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    93. Trimble WS. Septins: a highly conserved family of membrane-associated GTPases with functions in cell division and beyond. J Membr Biol. 1999 May 15; 169(2):75-81. PMID: 10341029.
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    94. Beites CL, Xie H, Bowser R, Trimble WS. The septin CDCrel-1 binds syntaxin and inhibits exocytosis. Nat Neurosci. 1999 May; 2(5):434-9. PMID: 10321247.
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    95. Foster LJ, Yaworsky K, Trimble WS, Klip A. SNAP23 promotes insulin-dependent glucose uptake in 3T3-L1 adipocytes: possible interaction with cytoskeleton. Am J Physiol. 1999 05; 276(5):C1108-14. PMID: 10329959.
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    96. Xie H, Surka M, Howard J, Trimble WS. Characterization of the mammalian septin H5: distinct patterns of cytoskeletal and membrane association from other septin proteins. Cell Motil Cytoskeleton. 1999; 43(1):52-62. PMID: 10340703.
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    97. Hua SY, Raciborska DA, Trimble WS, Charlton MP. Different VAMP/synaptobrevin complexes for spontaneous and evoked transmitter release at the crayfish neuromuscular junction. J Neurophysiol. 1998 Dec; 80(6):3233-46. PMID: 9862918.
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    98. Hackam DJ, Rotstein OD, Sjolin C, Schreiber AD, Trimble WS, Grinstein S. v-SNARE-dependent secretion is required for phagocytosis. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11691-6. PMID: 9751727.
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    99. Foster LJ, Yeung B, Mohtashami M, Ross K, Trimble WS, Klip A. Binary interactions of the SNARE proteins syntaxin-4, SNAP23, and VAMP-2 and their regulation by phosphorylation. Biochemistry. 1998 Aug 04; 37(31):11089-96. PMID: 9693005.
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    100. Raciborska DA, Trimble WS, Charlton MP. Presynaptic protein interactions in vivo: evidence from botulinum A, C, D and E action at frog neuromuscular junction. Eur J Neurosci. 1998 Aug; 10(8):2617-28. PMID: 9767392.
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    101. Weir ML, Klip A, Trimble WS. Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP. Biochem J. 1998 Jul 15; 333 ( Pt 2):247-51. PMID: 9657962.
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    102. Huang X, Wheeler MB, Kang YH, Sheu L, Lukacs GL, Trimble WS, Gaisano HY. Truncated SNAP-25 (1-197), like botulinum neurotoxin A, can inhibit insulin secretion from HIT-T15 insulinoma cells. Mol Endocrinol. 1998 Jul; 12(7):1060-70. PMID: 9658409.
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    103. Sadoul K, Berger A, Niemann H, Weller U, Roche PA, Klip A, Trimble WS, Regazzi R, Catsicas S, Halban PA. SNAP-23 is not cleaved by botulinum neurotoxin E and can replace SNAP-25 in the process of insulin secretion. J Biol Chem. 1997 Dec 26; 272(52):33023-7. PMID: 9407084.
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    104. Mandic R, Trimble WS, Lowe AW. Tissue-specific alternative RNA splicing of rat vesicle-associated membrane protein-1 (VAMP-1). Gene. 1997 Oct 15; 199(1-2):173-9. PMID: 9358054.
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    105. Gaisano HY, Sheu L, Wong PP, Klip A, Trimble WS. SNAP-23 is located in the basolateral plasma membrane of rat pancreatic acinar cells. FEBS Lett. 1997 Sep 08; 414(2):298-302. PMID: 9315706.
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    106. Kim PK, Janiak-Spens F, Trimble WS, Leber B, Andrews DW. Evidence for multiple mechanisms for membrane binding and integration via carboxyl-terminal insertion sequences. Biochemistry. 1997 Jul 22; 36(29):8873-82. PMID: 9220974.
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    107. Honer WG, Falkai P, Young C, Wang T, Xie J, Bonner J, Hu L, Boulianne GL, Luo Z, Trimble WS. Cingulate cortex synaptic terminal proteins and neural cell adhesion molecule in schizophrenia. Neuroscience. 1997 May; 78(1):99-110. PMID: 9135092.
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    108. Wong PP, Daneman N, Volchuk A, Lassam N, Wilson MC, Klip A, Trimble WS. Tissue distribution of SNAP-23 and its subcellular localization in 3T3-L1 cells. Biochem Biophys Res Commun. 1997 Jan 03; 230(1):64-8. PMID: 9020061.
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    109. Gaisano HY, Sheu L, Grondin G, Ghai M, Bouquillon A, Lowe A, Beaudoin A, Trimble WS. The vesicle-associated membrane protein family of proteins in rat pancreatic and parotid acinar cells. Gastroenterology. 1996 Dec; 111(6):1661-9. PMID: 8942747.
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    110. Gaisano HY, Ghai M, Malkus PN, Sheu L, Bouquillon A, Bennett MK, Trimble WS. Distinct cellular locations of the syntaxin family of proteins in rat pancreatic acinar cells. Mol Biol Cell. 1996 Dec; 7(12):2019-27. PMID: 8970162.
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    111. Wheeler MB, Sheu L, Ghai M, Bouquillon A, Grondin G, Weller U, Beaudoin AR, Bennett MK, Trimble WS, Gaisano HY. Characterization of SNARE protein expression in beta cell lines and pancreatic islets. Endocrinology. 1996 Apr; 137(4):1340-8. PMID: 8625909.
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    112. Boulianne GL, Trimble WS. Identification of a second homolog of N-ethylmaleimide-sensitive fusion protein that is expressed in the nervous system and secretory tissues of Drosophila. Proc Natl Acad Sci U S A. 1995 Jul 18; 92(15):7095-9. PMID: 7624376.
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    113. Volchuk A, Mitsumoto Y, He L, Liu Z, Habermann E, Trimble W, Klip A. Expression of vesicle-associated membrane protein 2 (VAMP-2)/synaptobrevin II and cellubrevin in rat skeletal muscle and in a muscle cell line. Biochem J. 1994 Nov 15; 304 ( Pt 1):139-45. PMID: 7998925.
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    114. Schiavo G, Malizio C, Trimble WS, Polverino de Laureto P, Milan G, Sugiyama H, Johnson EA, Montecucco C. Botulinum G neurotoxin cleaves VAMP/synaptobrevin at a single Ala-Ala peptide bond. J Biol Chem. 1994 Aug 12; 269(32):20213-6. PMID: 8051110.
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    115. Gaisano HY, Sheu L, Foskett JK, Trimble WS. Tetanus toxin light chain cleaves a vesicle-associated membrane protein (VAMP) isoform 2 in rat pancreatic zymogen granules and inhibits enzyme secretion. J Biol Chem. 1994 Jun 24; 269(25):17062-6. PMID: 7516331.
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    116. Georgiou J, Robitaille R, Trimble WS, Charlton MP. Synaptic regulation of glial protein expression in vivo. Neuron. 1994 Feb; 12(2):443-55. PMID: 7906531.
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    117. Trimble WS. Analysis of the structure and expression of the VAMP family of synaptic vesicle proteins. J Physiol Paris. 1993; 87(2):107-15. PMID: 8305898.
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    118. Cain CC, Trimble WS, Lienhard GE. Members of the VAMP family of synaptic vesicle proteins are components of glucose transporter-containing vesicles from rat adipocytes. J Biol Chem. 1992 Jun 15; 267(17):11681-4. PMID: 1601842.
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    119. Trimble WS, Linial M, Scheller RH. Cellular and molecular biology of the presynaptic nerve terminal. Annu Rev Neurosci. 1991; 14:93-122. PMID: 1851609.
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    120. Haliotis T, Trimble W, Chow S, Bull S, Mills G, Girard P, Kuo JF, Hozumi N. Expression of ras oncogene leads to down-regulation of protein kinase C. Int J Cancer. 1990 Jun 15; 45(6):1177-83. PMID: 2190939.
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    121. Trimble WS, Gray TS, Elferink LA, Wilson MC, Scheller RH. Distinct patterns of expression of two VAMP genes within the rat brain. J Neurosci. 1990 Apr; 10(4):1380-7. PMID: 2329380.
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    122. Ngsee JK, Trimble WS, Elferink LA, Wendland B, Miller K, Calakos N, Scheller RH. Molecular analysis of proteins associated with the synaptic vesicle membrane. Cold Spring Harb Symp Quant Biol. 1990; 55:111-8. PMID: 2132813.
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    123. Elferink LA, Trimble WS, Scheller RH. Two vesicle-associated membrane protein genes are differentially expressed in the rat central nervous system. J Biol Chem. 1989 Jul 05; 264(19):11061-4. PMID: 2472388.
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    124. Haliotis T, Trimble W, Chow S, Mills G, Girard P, Kuo JF, Govindji N, Hozumi N. The cell biology of ras-induced transformation: insights from studies utilizing an inducible hybrid oncogene system. Anticancer Res. 1988 Sep-Oct; 8(5A):935-45. PMID: 2845854.
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    125. Trimble WS, Cowan DM, Scheller RH. VAMP-1: a synaptic vesicle-associated integral membrane protein. Proc Natl Acad Sci U S A. 1988 Jun; 85(12):4538-42. PMID: 3380805.
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    126. Trimble WS, Scheller RH. Molecular biology of synaptic vesicle-associated proteins. Trends Neurosci. 1988 Jun; 11(6):241-2. PMID: 2465615.
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    127. Trimble WS, Hozumi N. Deletion analysis of the c-Ha-ras oncogene promoter. FEBS Lett. 1987 Jul 13; 219(1):70-4. PMID: 3474157.
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    128. Trimble WS, Boulianne GL, Hozumi N. Morphological transformation and tumorigenicity in C3H/10T1/2 cells transformed with an inducible c-Ha-ras oncogene. Biosci Rep. 1987 Jul; 7(7):579-85. PMID: 3318947.
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    129. Johnson PW, Trimble WS, Hozumi N, Roder JC. Enhanced lytic susceptibility of Ha-ras transformants after oncogene induction is specific to activated NK cells. J Immunol. 1987 Jun 01; 138(11):3996-4003. PMID: 3495578.
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    130. Trimble WS, Baker MD, Boulianne GL, Murialdo H, Hozumi N, Shulman MJ. Analysis of hybridoma mutants defective in synthesis of immunoglobulin M. Somat Cell Mol Genet. 1986 Sep; 12(5):467-77. PMID: 3020712.
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    131. Trimble WS, Johnson PW, Hozumi N, Roder JC. Inducible cellular transformation by a metallothionein-ras hybrid oncogene leads to natural killer cell susceptibility. Nature. 1986 Jun 19-25; 321(6072):782-4. PMID: 3520342.
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    132. Hawley RG, Trimble WS, Shulman MJ, Hozumi N. Transposition of intracisternal A-particle genes in mouse hybridomas. J Cell Physiol Suppl. 1984; 3:29-38. PMID: 6086685.
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