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Manuel Carcao

TitleStaff Physician
InstitutionThe Hospital for Sick Children
DepartmentHaematology/Oncology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Liesner RJ, Abraham A, Altisent C, Belletrutti MJ, Carcao M, Carvalho M, Chambost H, Chan AKC, Dubey L, Ducore J, Gattens M, Gresele P, Gruel Y, Guillet B, Jimenez-Yuste V, Kitanovski L, Klukowska A, Lohade S, Mancuso ME, Oldenburg J, Pavlova A, Pollio B, Sigaud M, Vdovin V, Vilchevska K, Wu JKM, Jansen M, Belyanskaya L, Walter O, Knaub S, Neufeld EJ. Simoctocog Alfa (Nuwiq) in Previously Untreated Patients with Severe Haemophilia A: Final Results of the NuProtect Study. Thromb Haemost. 2021 Feb 13. PMID: 33581698.
      View in: PubMed
    2. Carcao M, Mancuso ME, Young G, Jiménez-Yuste V. Key questions in the new hemophilia era: update on concomitant use of FVIII and emicizumab in hemophilia A patients with inhibitors. Expert Rev Hematol. 2021 Feb; 14(2):143-148. PMID: 33499681.
      View in: PubMed
    3. Blanchette V, Zunino L, Grassmann V, Barnes C, Carcao M, Curtain J, Jackson SC, Khoo L, Komrska V, Lillicrap D, Morfini M, Romanova G, Stephens D, Zapotocka E, Rand ML, Blatny J. A practical, one-clinic visit protocol for pharmacokinetic profile generation with the ADVATE® myPKFiT® dosing tool in severe hemophilia A subjects. Thromb Haemost. 2021 Jan 27. PMID: 33506480.
      View in: PubMed
    4. Carcao M, Shapiro A, Hwang N, Pipe S, Ahuja S, Lieuw K, Staber JM, Belletrutti M, Sun HL, Ding H, Wang M, Price V, Steele M, Tsao E, Feng J, Al-Khateeb Z, Dumont J, Jain N. Real-world data of immune tolerance induction using recombinant factor VIII Fc fusion protein in patients with severe haemophilia A with inhibitors at high risk for immune tolerance induction failure: A follow-up retrospective analysis. Haemophilia. 2021 Jan; 27(1):19-25. PMID: 33210397.
      View in: PubMed
    5. Srivastava A, Santagostino E, Dougall A, Kitchen S, Sutherland M, Pipe SW, Carcao M, Mahlangu J, Ragni MV, Windyga J, Llinás A, Goddard NJ, Mohan R, Poonnoose PM, Feldman BM, Lewis SZ, van den Berg HM, Pierce GF. WFH Guidelines for the Management of Hemophilia, 3rd edition. Haemophilia. 2020 Aug; 26 Suppl 6:1-158. PMID: 32744769.
      View in: PubMed
    6. Andersson NG, Wu R, Carcao M, Claeyssens-Donadel S, Kobelt R, Liesner R, Mäkipernaa A, Ranta S, Ljung R. Long-term follow-up of neonatal intracranial haemorrhage in children with severe haemophilia. Br J Haematol. 2020 07; 190(2):e101-e104. PMID: 32519345.
      View in: PubMed
    7. Tole S, Dhir P, Pugi J, Drury LJ, Butchart S, Fantauzzi M, Langer JC, Baker JM, Blanchette VS, Kirby-Allen M, Carcao MD. Genotype-phenotype correlation in children with hereditary spherocytosis. Br J Haematol. 2020 Nov; 191(3):486-496. PMID: 32436265.
      View in: PubMed
    8. Carcao M, Kearney S, Lu MY, Taki M, Rubens D, Shen C, Santagostino E. Long-Term Safety and Efficacy of Nonacog Beta Pegol (N9-GP) Administered for at Least 5 Years in Previously Treated Children with Hemophilia B. Thromb Haemost. 2020 May; 120(5):737-746. PMID: 32369845.
      View in: PubMed
    9. Carcao M, Silva M, David M, Klaassen RJ, Steele M, Price V, Wakefield C, Kim L, Stephens D, Blanchette VS. IVMP+IVIG raises platelet counts faster than IVIG alone: results of a randomized, blinded trial in childhood ITP. Blood Adv. 2020 04 14; 4(7):1492-1500. PMID: 32282882.
      View in: PubMed
    10. Duan L, Renzi S, Weidman D, Waespe N, Chami R, Manson D, Cada M, Carcao M. Sirolimus Treatment of an Infant With Intrathoracic Kaposiform Hemangioendothelioma Complicated by Life-threatening Pleural and Pericardial Effusions. J Pediatr Hematol Oncol. 2020 01; 42(1):74-78. PMID: 30044355.
      View in: PubMed
    11. Carcao M, Zunino L, Young NL, Dover S, Bouskill V, Hilliard P, Price VE, Blanchette VS. Measuring the impact of changing from standard half-life (SHL) to extended half-life (EHL) FVIII prophylaxis on health-related quality of life (HRQoL) in boys with moderate/severe haemophilia A: Lessons learned with the CHO-KLAT tool. Haemophilia. 2020 Jan; 26(1):73-78. PMID: 31865620.
      View in: PubMed
    12. Kieswetter L, Walters TD, Lara-Corrales I, Carcao MD, Ngan B, Pope E. Dieulafoy lesions and PHACE syndrome. Pediatr Dermatol. 2019 Nov; 36(6):902-905. PMID: 31359449.
      View in: PubMed
    13. Swystun LL, Ogiwara K, Rawley O, Brown C, Georgescu I, Hopman W, Labarque V, Male C, Thom K, Blanchette VS, Carcao MD, Lillicrap D. Genetic determinants of VWF clearance and FVIII binding modify FVIII pharmacokinetics in pediatric hemophilia A patients. Blood. 2019 09 12; 134(11):880-891. PMID: 31350267.
      View in: PubMed
    14. Egan G, Pluthero FG, Bouskill V, Hilliard P, Drury LJ, Carcao MD, Kahr WHA. Abnormal fibrinolysis recognized by thromboelastography in a case of severe bleeding with normal coagulation and platelet function, leads to detection of a novel SERPINF2 variant causing severe alpha-2-antiplasmin deficiency. Br J Haematol. 2019 09; 186(6):e198-e201. PMID: 31282989.
      View in: PubMed
    15. van den Berg HM, Fischer K, Carcao M, Chambost H, Kenet G, Kurnik K, Königs C, Male C, Santagostino E, Ljung R. Timing of inhibitor development in more than 1000 previously untreated patients with severe hemophilia A. Blood. 2019 07 18; 134(3):317-320. PMID: 31186271.
      View in: PubMed
    16. Chowdary P, Carcao M, Holme PA, Jiménez-Yuste V, Lentz SR, Møss J, Poulsen LH, Shen C, Tosetto A, Wheeler A, Santagostino E. Fixed doses of N8-GP prophylaxis maintain moderate-to-mild factor VIII levels in the majority of patients with severe hemophilia A. Res Pract Thromb Haemost. 2019 Jul; 3(3):542-554. PMID: 31294338.
      View in: PubMed
    17. Carcao MD, Chelle P, Clarke E, Kim L, Tiseo L, Morfini M, Hossain T, Rand ML, Brown C, Edginton AN, Lillicrap D, Iorio A, Blanchette VS. Comparative pharmacokinetics of two extended half-life FVIII concentrates (Eloctate and Adynovate) in adolescents with hemophilia A: Is there a difference? J Thromb Haemost. 2019 07; 17(7):1085-1096. PMID: 31038793.
      View in: PubMed
    18. Carcao M, Escuriola-Ettingshausen C, Santagostino E, Oldenburg J, Liesner R, Nolan B, Bátorová A, Haya S, Young G. The changing face of immune tolerance induction in haemophilia A with the advent of emicizumab. Haemophilia. 2019 Jul; 25(4):676-684. PMID: 31033112.
      View in: PubMed
    19. Tole S, Amid A, Baker J, Kuo K, Pugi J, Carcao M. Mild Hereditary Spherocytosis without Accompanying Hereditary Haemochromatosis: An Unrecognised Cause of Iron Overload. Acta Haematol. 2019; 141(4):256-260. PMID: 30965318.
      View in: PubMed
    20. Pelland-Marcotte MC, Carcao MD. Hemophilia in a Changing Treatment Landscape. Hematol Oncol Clin North Am. 2019 06; 33(3):409-423. PMID: 31030810.
      View in: PubMed
    21. Santagostino E, Young G, Escuriola Ettingshausen C, Jimenez-Yuste V, Carcao M. Inhibitors: A Need for Eradication? Acta Haematol. 2019; 141(3):151-155. PMID: 30783066.
      View in: PubMed
    22. Beck CE, Carcao M, Cada M, Porter S, Blanchette VS, Parkin PC. A Quality Improvement Bundle to Improve Informed Choice for Children With Typical, Newly Diagnosed Immune Thrombocytopenia. J Pediatr Hematol Oncol. 2018 11; 40(8):e537-e543. PMID: 30028824.
      View in: PubMed
    23. Oldenburg J, Carcao M, Lentz SR, Mahlangu J, Mancuso ME, Matsushita T, Négrier C, Clausen WHO, Ehrenforth S, Young G. Once-weekly prophylaxis with 40 IU/kg nonacog beta pegol (N9-GP) achieves trough levels of >15% in patients with haemophilia B: Pooled data from the paradigm™ trials. Haemophilia. 2018 Nov; 24(6):911-920. PMID: 30248217.
      View in: PubMed
    24. Mancuso ME, Bidlingmaier C, Mahlangu JN, Carcao M, Tosetto A. The predictive value of factor VIII/factor IX levels to define the severity of hemophilia: communication from the SSC of ISTH. J Thromb Haemost. 2018 10; 16(10):2106-2110. PMID: 30182468.
      View in: PubMed
    25. Pelland-Marcotte MC, Humpl T, James PD, Rand ML, Bouskill V, Reyes JT, Bowman ML, Carcao MD. Idiopathic pulmonary arterial hypertension - a unrecognized cause of high-shear high-flow haemostatic defects (otherwise referred to as acquired von Willebrand syndrome) in children. Br J Haematol. 2018 10; 183(2):267-275. PMID: 30141279.
      View in: PubMed
    26. Carcao M, Lambert T, Leissinger C, Escuriola-Ettingshausen C, Santagostino E, Aledort L. Prophylaxis re-visited: The potential impact of novel factor and non-factor therapies on prophylaxis. Haemophilia. 2018 11; 24(6):845-848. PMID: 29989273.
      View in: PubMed
    27. Pluthero FG, Di Paola J, Carcao MD, Kahr WHA. NBEAL2 mutations and bleeding in patients with gray platelet syndrome. Platelets. 2018 Sep; 29(6):632-635. PMID: 29869935.
      View in: PubMed
    28. Feldman BM, Rivard GE, Babyn P, Wu JKM, Steele M, Poon MC, Card RT, Israels SJ, Laferriere N, Gill K, Chan AK, Carcao M, Klaassen RJ, Cloutier S, Price VE, Dover S, Blanchette VS. Tailored frequency-escalated primary prophylaxis for severe haemophilia A: results of the 16-year Canadian Hemophilia Prophylaxis Study longitudinal cohort. Lancet Haematol. 2018 Jun; 5(6):e252-e260. PMID: 29731369.
      View in: PubMed
    29. Carcao M, Altisent C, Castaman G, Fukutake K, Kerlin BA, Kessler C, Lassila R, Nugent D, Oldenburg J, Garly ML, Rosholm A, Inbal A. Recombinant FXIII (rFXIII-A2) Prophylaxis Prevents Bleeding and Allows for Surgery in Patients with Congenital FXIII A-Subunit Deficiency. Thromb Haemost. 2018 03; 118(3):451-460. PMID: 29448295.
      View in: PubMed
    30. Carcao M, Shapiro A, Staber JM, Hwang N, Druzgal C, Lieuw K, Belletrutti M, Thornburg CD, Ahuja SP, Morales-Arias J, Dumont J, Miyasato G, Tsao E, Jain N, Pipe SW. Recombinant factor VIII Fc fusion protein for immune tolerance induction in patients with severe haemophilia A with inhibitors-A retrospective analysis. Haemophilia. 2018 Mar; 24(2):245-252. PMID: 29436077.
      View in: PubMed
    31. Pugi J, Carcao M, Drury LJ, Langer JC. Results after laparoscopic partial splenectomy for children with hereditary spherocytosis: Are outcomes influenced by genetic mutation? J Pediatr Surg. 2018 May; 53(5):973-975. PMID: 29506817.
      View in: PubMed
    32. Loomans JI, Kruip MJHA, Carcao M, Jackson S, van Velzen AS, Peters M, Santagostino E, Platokouki H, Beckers E, Voorberg J, van der Bom JG, Fijnvandraat K. Desmopressin in moderate hemophilia A patients: a treatment worth considering. Haematologica. 2018 03; 103(3):550-557. PMID: 29305412.
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    33. Santagostino E, Young G, Carcao M, Mannucci PM, Halimeh S, Austin S. A contemporary look at FVIII inhibitor development: still a great influence on the evolution of hemophilia therapies. Expert Rev Hematol. 2018 02; 11(2):87-97. PMID: 29258406.
      View in: PubMed
    34. Platokouki H, Fischer K, Gouw SC, Rafowicz A, Carcao M, Kenet G, Liesner R, Kurnik K, Rivard GE, van den Berg HM. Vaccinations are not associated with inhibitor development in boys with severe haemophilia A. Haemophilia. 2018 Mar; 24(2):283-290. PMID: 29243367.
      View in: PubMed
    35. Mancuso ME, Fischer K, Santagostino E, Oldenburg J, Platokouki H, Königs C, Escuriola-Ettingshausen C, Rivard GE, Cid AR, Carcao M, Ljung R, Petrini P, Altisent C, Kenet G, Liesner R, Kurnik K, Auerswald G, Chambost H, Mäkipernaa A, Molinari AC, Williams M, van den Berg HM. Risk Factors for the Progression from Low to High Titres in 260 Children with Severe Haemophilia A and Newly Developed Inhibitors. Thromb Haemost. 2017 12; 117(12):2274-2282. PMID: 29212115.
      View in: PubMed
    36. Liesner RJ, Abashidze M, Aleinikova O, Altisent C, Belletrutti MJ, Borel-Derlon A, Carcao M, Chambost H, Chan AKC, Dubey L, Ducore J, Fouzia NA, Gattens M, Gruel Y, Guillet B, Kavardakova N, El Khorassani M, Klukowska A, Lambert T, Lohade S, Sigaud M, Turea V, Wu JKM, Vdovin V, Pavlova A, Jansen M, Belyanskaya L, Walter O, Knaub S, Neufeld EJ. Immunogenicity, efficacy and safety of Nuwiq® (human-cl rhFVIII) in previously untreated patients with severe haemophilia A-Interim results from the NuProtect Study. Haemophilia. 2018 Mar; 24(2):211-220. PMID: 28815880.
      View in: PubMed
    37. Andersson NG, Auerswald G, Barnes C, Carcao M, Dunn AL, Fijnvandraat K, Hoffmann M, Kavakli K, Kenet G, Kobelt R, Kurnik K, Liesner R, Mäkipernaa A, Manco-Johnson MJ, Mancuso ME, Molinari AC, Nolan B, Perez Garrido R, Petrini P, Platokouki HE, Shapiro AD, Wu R, Ljung R. Intracranial haemorrhage in children and adolescents with severe haemophilia A or B - the impact of prophylactic treatment. Br J Haematol. 2017 10; 179(2):298-307. PMID: 28699675.
      View in: PubMed
    38. Keepanasseril A, Stoffman J, Bouskill V, Carcao M, Iorio A, Jackson S. Switching to extended half-life products in Canada - preliminary data. Haemophilia. 2017 07; 23(4):e365-e367. PMID: 28548284.
      View in: PubMed
    39. Al-Battat S, Rand ML, Bouskill V, Lau W, Blanchette VS, Kahr WHA, Rivard GE, Carcao MD. Glanzmann thrombasthenia platelets compete with transfused platelets, reducing the haemostatic impact of platelet transfusions. Br J Haematol. 2018 05; 181(3):410-413. PMID: 28466602.
      View in: PubMed
    40. Carcao MD, Avila L, Leissinger C, Blanchette VS, Aledort L. An International Prophylaxis Study Group (IPSG) survey of prophylaxis in inhibitor positive children/adults with severe haemophilia. Haemophilia. 2017 09; 23(5):e444-e447. PMID: 28439934.
      View in: PubMed
    41. Carneiro JDA, Blanchette V, Ozelo MC, Antunes SV, Villaca PR, Young NL, Castro D, Brandão LR, Carcao M, Abad A, Feldman BM. Comparing the burden of illness of haemophilia between resource-constrained and unconstrained countries: the São Paulo-Toronto Hemophilia Study. Haemophilia. 2017 Sep; 23(5):682-688. PMID: 28440005.
      View in: PubMed
    42. Carcao MD, Avila L, Leissinger C, Blanchette VS, Aledort L. An International Prophylaxis Study Group (IPSG) survey of prophylaxis in adults with severe haemophilia. Haemophilia. 2017 09; 23(5):e447-e450. PMID: 28429874.
      View in: PubMed
    43. Labarque V, Perinparajah V, Bouskill V, Stain AM, Wakefield C, Manuel C, Blanchette VS, James PD, Lillicrap D, Carcao MD. Utility of factor VIII and factor VIII to von Willebrand factor ratio in identifying 277 unselected carriers of hemophilia A. Am J Hematol. 2017 06; 92(6):E94-E96. PMID: 28249352.
      View in: PubMed
    44. Carcao M, Kearney S, Santagostino E, Oyesiku JOO, Young NL, Meunier J, Hoxer CS, Zhang C, Blanchette VS. Insight into health-related quality of life of young children with haemophilia B treated with long-acting nonacog beta pegol recombinant factor IX. Haemophilia. 2017 05; 23(3):e222-e224. PMID: 28371032.
      View in: PubMed
    45. Tiede A, Abdul-Karim F, Carcao M, Persson P, Clausen WHO, Kearney S, Matsushita T, Negrier C, Oldenburg J, Santagostino E, Young G. Pharmacokinetics of a novel extended half-life glycoPEGylated factor IX, nonacog beta pegol (N9-GP) in previously treated patients with haemophilia B: results from two phase 3 clinical trials. Haemophilia. 2017 Jul; 23(4):547-555. PMID: 28233381.
      View in: PubMed
    46. Sholzberg M, Floros G, Schneiderman JE, Kahr WH, Rand M, Pluthero F, Hossain T, Mahamad S, Nisenbaum R, Zhang C, O'Neill NE, Teitel J, Carcao M. Effect of moderate intensity exercise on haemostatic capacity in adults with haemophilia A and B: pilot study. Haemophilia. 2017 03; 23(2):e162-e165. PMID: 28111839.
      View in: PubMed
    47. Fischer K, Poonnoose P, Dunn AL, Babyn P, Manco-Johnson MJ, David JA, van der Net J, Feldman B, Berger K, Carcao M, de Kleijn P, Silva M, Hilliard P, Doria A, Srivastava A, Blanchette V. Choosing outcome assessment tools in haemophilia care and research: a multidisciplinary perspective. Haemophilia. 2017 Jan; 23(1):11-24. PMID: 27633342.
      View in: PubMed
    48. Carcao M, Fukutake K, Inbal A, Kerlin B, Lassila R, Oldenburg J, Garly ML, Nugent D. Developing the First Recombinant Factor XIII for Congenital Factor XIII Deficiency: Clinical Challenges and Successes. Semin Thromb Hemost. 2017 Feb; 43(1):59-68. PMID: 27556350.
      View in: PubMed
    49. Bouskill V, Hilliard P, Stephens S, Zhang C, Whitney K, Carcao M. An institutional pilot study to investigate physical activity patterns in boys with haemophilia. Haemophilia. 2016 Sep; 22(5):e383-9. PMID: 27530715.
      View in: PubMed
    50. Crivianu-Gaita V, Rivard GE, Carcao M, Teitel J, St-Louis J, Blanchette V, Pullenayegum E, Abad A, Feldman BM. Pilot study of once-a-day prophylaxis for youth and young adults with severe haemophilia A. Haemophilia. 2016 Sep; 22(5):e401-5. PMID: 27481574.
      View in: PubMed
    51. Carcao M, Zak M, Abdul Karim F, Hanabusa H, Kearney S, Lu MY, Persson P, Rangarajan S, Santagostino E. Nonacog beta pegol in previously treated children with hemophilia B: results from an international open-label phase 3 trial. J Thromb Haemost. 2016 08; 14(8):1521-9. PMID: 27174727.
      View in: PubMed
    52. Kumar R, Bouskill V, Schneiderman JE, Pluthero FG, Kahr WH, Craik A, Clark D, Whitney K, Zhang C, Rand ML, Carcao M. Impact of aerobic exercise on haemostatic indices in paediatric patients with haemophilia. Thromb Haemost. 2016 06 02; 115(6):1120-8. PMID: 26917411.
      View in: PubMed
    53. Ljung R, Fischer K, Carcao M, Santagostino E, Manco-Johnson MJ, Mathew P. Practical considerations in choosing a factor VIII prophylaxis regimen: Role of clinical phenotype and trough levels. Thromb Haemost. 2016 05 02; 115(5):913-20. PMID: 26791493.
      View in: PubMed
    54. Kumar R, Dunn A, Carcao M. Changing Paradigm of Hemophilia Management: Extended Half-Life Factor Concentrates and Gene Therapy. Semin Thromb Hemost. 2016 Feb; 42(1):18-29. PMID: 26771678.
      View in: PubMed
    55. van den Berg HM, Hashemi SM, Fischer K, Petrini P, Ljung R, Rafowicz A, Carcao M, Auerswald G, Kurnik K, Kenet G, Santagostino E. Increased inhibitor incidence in severe haemophilia A since 1990 attributable to more low titre inhibitors. Thromb Haemost. 2016 Apr; 115(4):729-37. PMID: 26632988.
      View in: PubMed
    56. Carcao M, Hilliard P, Escobar MA, Solimeno L, Mahlangu J, Santagostino E. Optimising musculoskeletal care for patients with haemophilia. Eur J Haematol. 2015 Dec; 95 Suppl 81:11-21. PMID: 26679393.
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    57. Carcao M, Srivastava A. Factor VIII/factor IX prophylaxis for severe hemophilia. Semin Hematol. 2016 Jan; 53(1):3-9. PMID: 26805901.
      View in: PubMed
    58. Carcao M, Re W, Ewenstein B. The role of previously untreated patient studies in understanding the development of FVIII inhibitors. Haemophilia. 2016 Jan; 22(1):22-31. PMID: 26315604.
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    59. Carcao MD, Iorio A. Individualizing factor replacement therapy in severe hemophilia. Semin Thromb Hemost. 2015 Nov; 41(8):864-71. PMID: 26270111.
      View in: PubMed
    60. Abshire T, Cox-Gill J, Kempton CL, Leebeek FW, Carcao M, Kouides P, Donfield S, Berntorp E. Prophylaxis escalation in severe von Willebrand disease: a prospective study from the von Willebrand Disease Prophylaxis Network. J Thromb Haemost. 2015 Sep; 13(9):1585-9. PMID: 25930155.
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    61. Holm E, Abshire TC, Bowen J, Álvarez MT, Bolton-Maggs P, Carcao M, Federici AB, Gill JC, Halimeh S, Kempton C, Key NS, Kouides P, Lail A, Landorph A, Leebeek F, Makris M, Mannucci P, Mauser-Bunschoten EP, Nugent D, Valentino LA, Winikoff R, Berntorp E. Changes in bleeding patterns in von Willebrand disease after institution of long-term replacement therapy: results from the von Willebrand Disease Prophylaxis Network. Blood Coagul Fibrinolysis. 2015 Jun; 26(4):383-8. PMID: 25688461.
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    62. Wasserman JD, Mahant S, Carcao M, Perlman K, Pope E. Vincristine for successful treatment of steroid-dependent infantile hemangiomas. Pediatrics. 2015 Jun; 135(6):e1501-5. PMID: 25986022.
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    63. Carcao M. Switching from current factor VIII (FVIII) to longer acting FVIII concentrates--what is the real potential benefit? Haemophilia. 2015 May; 21(3):297-9. PMID: 25854624.
      View in: PubMed
    64. Brand-Staufer B, Carcao M, Kerlin BA, Will A, Williams M, Tornøe CW, Sandberg Lundblad M, Nugent D. Pharmacokinetic characterization of recombinant factor XIII (FXIII)-A2 across age groups in patients with FXIII A-subunit congenital deficiency. Haemophilia. 2015 May; 21(3):380-5. PMID: 25643920.
      View in: PubMed
    65. Nijdam A, Altisent C, Carcao MD, Cid AR, Claeyssens-Donadel S, Kurnik K, Ljung R, Nolan B, Petrini P, Platokouki H, Rafowicz A, Thomas AE, Fischer K. Bleeding before prophylaxis in severe hemophilia: paradigm shift over two decades. Haematologica. 2015 Mar; 100(3):e84-6. PMID: 25527565.
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    66. Avila ML, Lee KJ, Bouskill V, Rand ML, James P, Carcao M. Acquired von Willebrand syndrome in paediatric patients with congenital heart disease: challenges in the diagnosis and management of this rare condition. Haemophilia. 2015 Jan; 21(1):e89-92. PMID: 25495773.
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    67. Vézina C, Carcao M, Infante-Rivard C, Lillicrap D, Stain AM, Paradis E, Teitel J, Rivard GE. Incidence and risk factors for inhibitor development in previously untreated severe haemophilia A patients born between 2005 and 2010. Haemophilia. 2014 Nov; 20(6):771-6. PMID: 25039669.
      View in: PubMed
    68. Carcao M. Changing paradigm of prophylaxis with longer acting factor concentrates. Haemophilia. 2014 May; 20 Suppl 4:99-105. PMID: 24762284.
      View in: PubMed
    69. Carcao M. A new era of therapy for congenital factor XIII deficiency. Clin Adv Hematol Oncol. 2014 May; 12(5):326-8. PMID: 25003489.
      View in: PubMed
    70. Kumar R, Carcao M. Inherited abnormalities of coagulation: hemophilia, von Willebrand disease, and beyond. Pediatr Clin North Am. 2013 Dec; 60(6):1419-41. PMID: 24237980.
      View in: PubMed
    71. Leissinger C, Carcao M, Gill JC, Journeycake J, Singleton T, Valentino L. Desmopressin (DDAVP) in the management of patients with congenital bleeding disorders. Haemophilia. 2014 Mar; 20(2):158-67. PMID: 23937614.
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    72. Kumar R, Stain AM, Hilliard P, Carcao M. Consequences of delayed therapy for sports-related bleeds in patients with mild-to-moderate haemophilia and type 3 von Willebrand's disease not on prophylaxis. Haemophilia. 2013 Jul; 19(4):e264-7. PMID: 23647798.
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    73. Labarque V, Stain AM, Blanchette V, Kahr WH, Carcao MD. Intracranial haemorrhage in von Willebrand disease: a report on six cases. Haemophilia. 2013 Jul; 19(4):602-6. PMID: 23556472.
      View in: PubMed
    74. Gouw SC, van den Berg HM, Fischer K, Auerswald G, Carcao M, Chalmers E, Chambost H, Kurnik K, Liesner R, Petrini P, Platokouki H, Altisent C, Oldenburg J, Nolan B, Garrido RP, Mancuso ME, Rafowicz A, Williams M, Clausen N, Middelburg RA, Ljung R, van der Bom JG. Intensity of factor VIII treatment and inhibitor development in children with severe hemophilia A: the RODIN study. Blood. 2013 May 16; 121(20):4046-55. PMID: 23553768.
      View in: PubMed
    75. Carcao MD, van den Berg HM, Ljung R, Mancuso ME. Correlation between phenotype and genotype in a large unselected cohort of children with severe hemophilia A. Blood. 2013 May 09; 121(19):3946-52, S1. PMID: 23482934.
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    76. Carcao M, Malkin D, Aledort L. Symposium on congenital and acquired bleeding disorders in children (in honor of the lifetime accomplishments of Dr. Victor S. Blanchette in pediatric hematology). Pediatr Blood Cancer. 2013; 60 Suppl 1:S1. PMID: 23109167.
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    77. Carcao MD. The diagnosis and management of congenital hemophilia. Semin Thromb Hemost. 2012 Oct; 38(7):727-34. PMID: 23011791.
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    78. Abshire TC, Federici AB, Alvárez MT, Bowen J, Carcao MD, Cox Gill J, Key NS, Kouides PA, Kurnik K, Lail AE, Leebeek FW, Makris M, Mannucci PM, Winikoff R, Berntorp E. Prophylaxis in severe forms of von Willebrand's disease: results from the von Willebrand Disease Prophylaxis Network (VWD PN). Haemophilia. 2013 Jan; 19(1):76-81. PMID: 22823000.
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    79. Peyvandi F, Klamroth R, Carcao M, Federici AB, DI Minno G, Jiménez-Yuste V, Rodriguez Merchán EC. Management of bleeding disorders in adults. Haemophilia. 2012 May; 18 Suppl 2:24-36. PMID: 22530576.
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    80. Feldman BM, Berger K, Bohn R, Carcao M, Fischer K, Gringeri A, Hoots K, Mantovani L, Willan AR, Schramm W. Haemophilia prophylaxis: how can we justify the costs? Haemophilia. 2012 Sep; 18(5):680-4. PMID: 22507524.
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    81. Webb BD, Barrera M, Beyene J, Carcao M, Daneman D, Elliott I, Gong GW, Halperin IJ, Lord S, Melville H, Narayanan UG, Ota S, Solomon M, Sung L, Young NL, Zachos M, Feldman BM. Determinants of quality of life in children with chronic somatic disease: pilot data from the GapS Questionnaire. Qual Life Res. 2013 Mar; 22(2):339-49. PMID: 22461136.
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    82. Inbal A, Oldenburg J, Carcao M, Rosholm A, Tehranchi R, Nugent D. Recombinant factor XIII: a safe and novel treatment for congenital factor XIII deficiency. Blood. 2012 May 31; 119(22):5111-7. PMID: 22451421.
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    83. Chiu YE, Drolet BA, Blei F, Carcao M, Fangusaro J, Kelly ME, Krol A, Lofgren S, Mancini AJ, Metry DW, Recht M, Silverman RA, Tom WL, Pope E. Variable response to propranolol treatment of kaposiform hemangioendothelioma, tufted angioma, and Kasabach-Merritt phenomenon. Pediatr Blood Cancer. 2012 Nov; 59(5):934-8. PMID: 22648868.
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    84. Webert KE, Rivard GE, Teitel J, Carcao M, Lillicrap D, St-Louis J, Walker IR. Low prevalence of inhibitor antibodies in the Canadian haemophilia population. Haemophilia. 2012 May; 18(3):e254-9. PMID: 22077390.
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    85. Robertson JD, Yenson PR, Rand ML, Blanchette VS, Carcao MD, Notley C, Lillicrap D, James PD. Expanded phenotype-genotype correlations in a pediatric population with type 1 von Willebrand disease. J Thromb Haemost. 2011 Sep; 9(9):1752-60. PMID: 21711445.
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    86. Sharathkumar AA, Carcao M. Clinical advances in hemophilia management. Pediatr Blood Cancer. 2011 Dec 01; 57(6):910-20. PMID: 21755590.
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    87. Tsangaris E, Klaassen R, Fernandez CV, Yanofsky R, Shereck E, Champagne J, Silva M, Lipton JH, Brossard J, Michon B, Abish S, Steele M, Ali K, Dower N, Athale U, Jardine L, Hand JP, Odame I, Canning P, Allen C, Carcao M, Beyene J, Roifman CM, Dror Y. Genetic analysis of inherited bone marrow failure syndromes from one prospective, comprehensive and population-based cohort and identification of novel mutations. J Med Genet. 2011 Sep; 48(9):618-28. PMID: 21659346.
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    88. Seary ME, Feldman D, Carcao MD. DDAVP responsiveness in children with mild or moderate haemophilia A correlates with age, endogenous FVIII:C level and with haemophilic genotype. Haemophilia. 2012 Jan; 18(1):50-5. PMID: 21592259.
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    89. Gupta M, Lillicrap D, Stain AM, Friedman KD, Carcao MD. Therapeutic consequences for misdiagnosis of type 2N von Willebrand disease. Pediatr Blood Cancer. 2011 Dec 01; 57(6):1081-3. PMID: 21425451.
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    90. Shahein AR, Gonzalez S, Carcao M, Abdelhaleem M, Hellmann J, McNamara PJ. A case of severe eosinophilia in a preterm infant. Pediatrics. 2011 Mar; 127(3):e767-71. PMID: 21357337.
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    91. Carcao MD, Seary ME, Casas M, Winter L, Stain AM, Judd P. Dental disease in type 3 Von Willebrand disease: a neglected problem. Haemophilia. 2010 Nov; 16(6):943-8. PMID: 20565545.
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    92. Carcao M, Chambost H, Ljung R. Devising a best practice approach to prophylaxis in boys with severe haemophilia: evaluation of current treatment strategies. Haemophilia. 2010 Mar; 16 Suppl 2:4-9. PMID: 20132332.
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    93. Carcao M, Lambert T. Prophylaxis in haemophilia with inhibitors: update from international experience. Haemophilia. 2010 Mar; 16 Suppl 2:16-23. PMID: 20132334.
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    94. Khan U, Bogue C, Ungar WJ, Hilliard P, Carcao M, Moineddin R, Doria AS. Cost-effectiveness analysis of different imaging strategies for diagnosis of haemophilic arthropathy. Haemophilia. 2010 Mar; 16(2):322-32. PMID: 20028424.
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    95. Valentino LA, Carcao M, Mathew P, Leissinger CA, Berntorp E, Blanchette V, Escuriola-Ettingshausen C, Ewenstein B, Ewing N, Gringeri A, Hoots WK, Negrier C. The application of bypassing-agent prophylaxis in haemophilia A patients with inhibitors: a meeting report. Haemophilia. 2009 Jul; 15(4):959-65. PMID: 19320750.
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    96. Carcao MD. Side-effects and venous access issues with immune tolerance therapy. Haemophilia. 2009 Mar; 15(2):494-500. PMID: 19347990.
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    97. Walsh MA, Carcao M, Pope E, Lee KJ. Kaposiform hemangioendothelioma presenting antenatally with a pericardial effusion. J Pediatr Hematol Oncol. 2008 Oct; 30(10):761-3. PMID: 19011475.
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    98. Teitel JM, Carcao M, Lillicrap D, Mulder K, Rivard GE, St-Louis J, Smith F, Walker I, Zourikian N. Orthopaedic surgery in haemophilia patients with inhibitors: a practical guide to haemostatic, surgical and rehabilitative care. Haemophilia. 2009 Jan; 15(1):227-39. PMID: 18752535.
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    99. Robertson JD, Connolly B, Hilliard P, Wedge J, Babyn P, Carcao M. Acute haemarthrosis of the hip joint: rapid convalescence following ultrasound-guided needle aspiration. Haemophilia. 2009 Jan; 15(1):390-3. PMID: 18691373.
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    100. Biss TT, Chan AK, Blanchette VS, Iwenofu LN, McLimont M, Carcao MD. The use of prophylaxis in 2663 children and adults with haemophilia: results of the 2006 Canadian national haemophilia prophylaxis survey. Haemophilia. 2008 Sep; 14(5):923-30. PMID: 18637844.
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    101. Heller M, Lau W, Pazmino-Canizares J, Brandão LR, Carcao M. A comprehensive review of rFVIIa use in a tertiary care pediatric center. Pediatr Blood Cancer. 2008 May; 50(5):1013-7. PMID: 17960639.
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    102. Bartakke S, Abdelhaleem M, Carcao M. Valproate-induced pure red cell aplasia and megakaryocyte dysplasia. Br J Haematol. 2008 Apr; 141(2):133. PMID: 18353161.
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    103. Carcao MD, Webert KE. On-label versus off-label use of recombinant activated factor VII: a comprehensive review of use in two Canadian centers. Semin Hematol. 2008 Apr; 45(2 Suppl 1):S68-71. PMID: 18544429.
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    104. Rubinger M, Lillicrap D, Rivard GE, Teitel J, Carcao M, Hensman C, Walker I. A prospective surveillance study of factor VIII inhibitor development in the Canadian haemophilia A population following the switch to a recombinant factor VIII product formulated with sucrose. Haemophilia. 2008 Mar; 14(2):281-6. PMID: 18194308.
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    105. Nicholson A, Berger K, Bohn R, Carcao M, Fischer K, Gringeri A, Hoots K, Mantovani L, Schramm W, van Hout BA, Willan AR, Feldman BM. Recommendations for reporting economic evaluations of haemophilia prophylaxis: a nominal groups consensus statement on behalf of the Economics Expert Working Group of The International Prophylaxis Study Group. Haemophilia. 2008 Jan; 14(1):127-32. PMID: 18005148.
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    106. Traivaree C, Blanchette V, Armstrong D, Floros G, Stain AM, Carcao MD. Intracranial bleeding in haemophilia beyond the neonatal period--the role of CT imaging in suspected intracranial bleeding. Haemophilia. 2007 Sep; 13(5):552-9. PMID: 17880443.
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    107. Kalbani NA, Weitzman S, Abdelhaleem M, Carcao M, Abla O. Acute lymphoblastic leukemia presenting with gross hematuria. Paediatr Child Health. 2007 Sep; 12(7):573-4. PMID: 19030428.
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    108. Carcao MD, Aledort LM. Prophylaxis in the haemophilia population-optimizing therapy. Haemophilia. 2007 May; 13(3):227-32. PMID: 17498070.
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    109. Zukotynski K, Jarrin J, Babyn PS, Carcao M, Pazmino-Canizares J, Stain AM, Doria AS. Sonography for assessment of haemophilic arthropathy in children: a systematic protocol. Haemophilia. 2007 May; 13(3):293-304. PMID: 17498079.
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    110. Gong GW, Barrera M, Beyene J, Bhat S, Carcao M, Lord S, Narayanan UG, Sung L, Young NL, Feldman BM. The Gap Study (GapS) interview--developing a process to determine the meaning and determinants of quality of life in children with arthritis and rheumatic disease. Clin Exp Rheumatol. 2007 May-Jun; 25(3):486-93. PMID: 17631751.
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    111. Barnes C, Blanchette V, Lillicrap D, Mann K, Stain AM, Leggo J, Hilliard P, Carcao M. Different clinical phenotype in triplets with haemophilia A. Haemophilia. 2007 Mar; 13(2):202-5. PMID: 17286775.
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    112. Ota S, Mclimont M, Carcao MD, Blanchette VS, Graham N, Paradis E, Feldman BM. Definitions for haemophilia prophylaxis and its outcomes: the Canadian consensus study. Haemophilia. 2007 Jan; 13(1):12-20. PMID: 17212719.
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    113. Di Paola J, Aledort L, Britton H, Carcao M, Grabowski E, Hutter J, Journeycake J, Kempton C, Leissinger C. Application of current knowledge to the management of bleeding events during immune tolerance induction. Haemophilia. 2006 Nov; 12(6):591-7. PMID: 17083508.
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    114. Das P, Carcao M, Hitzler J. Use of recombinant factor VIIa prior to lumbar puncture in pediatric patients with acute leukemia. Pediatr Blood Cancer. 2006 Aug; 47(2):206-9. PMID: 16007583.
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    115. Hay C, Recht M, Carcao M, Reipert B. Current and future approaches to inhibitor management and aversion. Semin Thromb Hemost. 2006 Jun; 32 Suppl 2:15-21. PMID: 16804831.
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    116. Barnes C, Rivard GE, Poon MC, Teitel J, Pai M, Kern M, Blanchette VS, Carcao M. Canadian multi-institutional survey of immune tolerance therapy (ITT) -- experience with the use of recombinant factor VIII for ITT. Haemophilia. 2006 Jan; 12(1):1-6. PMID: 16409169.
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    117. Carcao M, St Louis J, Poon MC, Grunebaum E, Lacroix S, Stain AM, Blanchette VS, Rivard GE. Rituximab for congenital haemophiliacs with inhibitors: a Canadian experience. Haemophilia. 2006 Jan; 12(1):7-18. PMID: 16409170.
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    118. Das P, Carcao M, Hitzler J. DDAVP-induced hyponatremia in young children. J Pediatr Hematol Oncol. 2005 Jun; 27(6):330-2. PMID: 15956888.
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    119. Barnes C, Blanchette V, Canning P, Carcao M. Recombinant FVIIa in the management of intracerebral haemorrhage in severe thrombocytopenia unresponsive to platelet-enhancing treatment. Transfus Med. 2005 Apr; 15(2):145-50. PMID: 15859982.
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    120. Barnes C, Gerstle JT, Freedman MH, Carcao MD. Clostridium septicum myonecrosis in congenital neutropenia. Pediatrics. 2004 Dec; 114(6):e757-60. PMID: 15574607.
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    121. Das PK, Grant R, Malkin D, Lee KJ, Ngan B, MacDonald CE, Carcao M. Lymphomatous involvement of the heart in children: two cases and a review of the literature. J Pediatr Hematol Oncol. 2004 Dec; 26(12):852-4. PMID: 15591913.
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    122. Carcao MD, Aledort L. Prophylactic factor replacement in hemophilia. Blood Rev. 2004 Jun; 18(2):101-13. PMID: 15010149.
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    123. Price VE, Carcao M, Connolly B, Chait P, Daneman A, Temple M, Stain AM, Sung L, Al-Tralbosi H, Blanchette VS. A prospective, longitudinal study of central venous catheter-related deep venous thrombosis in boys with hemophilia. J Thromb Haemost. 2004 May; 2(5):737-42. PMID: 15099279.
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    124. Orsino A, Schneider R, DeVeber G, Grant R, Massicotte P, Canning P, Carcao M. Childhood acute myelomonocytic leukemia (AML-M4) presenting as catastrophic antiphospholipid antibody syndrome. J Pediatr Hematol Oncol. 2004 May; 26(5):327-30. PMID: 15111789.
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    125. Carcao M, Ungar WJ, Feldman BM. Cost-utility analysis in evaluating prophylaxis in haemophilia. Haemophilia. 2004 Mar; 10 Suppl 1:50-7. PMID: 14987249.
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    126. Blanchette VS, Carcao M. Childhood acute immune thrombocytopenic purpura: 20 years later. Semin Thromb Hemost. 2003 Dec; 29(6):605-17. PMID: 14719177.
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    127. Revel-Vilk S, Schmugge M, Carcao MD, Blanchette P, Rand ML, Blanchette VS. Desmopressin (DDAVP) responsiveness in children with von Willebrand disease. J Pediatr Hematol Oncol. 2003 Nov; 25(11):874-9. PMID: 14608197.
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    128. Bobey NA, Carcao M, Dror Y, Freedman MH, Dahl N, Woodman RC. Sustained cyclosporine-induced erythropoietic response in identical male twins with diamond-blackfan anemia. J Pediatr Hematol Oncol. 2003 Nov; 25(11):914-8. PMID: 14608205.
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    129. Carcao MD, Connolly BL, Chait P, Stain AM, Acebes M, Massicotte P, Blanchette VS. Central venous catheter-related thrombosis presenting as superior vena cava syndrome in a haemophilic patient with inhibitors. Haemophilia. 2003 Sep; 9(5):578-83. PMID: 14511297.
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    130. Sharathkumar A, Lillicrap D, Blanchette VS, Kern M, Leggo J, Stain AM, Brooker L, Carcao MD. Intensive exposure to factor VIII is a risk factor for inhibitor development in mild hemophilia A. J Thromb Haemost. 2003 Jun; 1(6):1228-36. PMID: 12871324.
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    131. Carcao MD, Blanchette VS, Wakefield CD, Stephens D, Ellis J, Matheson K, Denomme GA. Fcgamma receptor IIa and IIIa polymorphisms in childhood immune thrombocytopenic purpura. Br J Haematol. 2003 Jan; 120(1):135-41. PMID: 12492589.
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    132. Sung L, King SM, Carcao M, Trebo M, Weitzman SS. Adverse outcomes in primary hemophagocytic lymphohistiocytosis. J Pediatr Hematol Oncol. 2002 Oct; 24(7):550-4. PMID: 12368693.
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    133. Berman J, Young N, Carcao M, Blanchette V, Ipp M. Hospitalization of children with acute immune thrombocytopenic purpura - is it necessary? Paediatr Child Health. 2002 Jul; 7(6):386-9. PMID: 20046330.
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    134. Revel-Vilk S, Blanchette VS, Sparling C, Stain AM, Carcao MD. DDAVP challenge tests in boys with mild/moderate haemophilia A. Br J Haematol. 2002 Jun; 117(4):947-51. PMID: 12060135.
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    135. Carcao MD, Blanchette VS, Stephens D, He L, Wakefield CD, Butchart S, Christie DJ, Rand ML. Assessment of thrombocytopenic disorders using the Platelet Function Analyzer (PFA-100). Br J Haematol. 2002 Jun; 117(4):961-4. PMID: 12060138.
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    136. Waye JS, Eng B, Patterson M, Carcao MD, Chang L, Olivieri NF, Chui DH. Identification of two new alpha-thalassemia mutations in exon 2 of the alpha1-globin gene. Hemoglobin. 2001 Nov; 25(4):391-6. PMID: 11791872.
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    137. Waye JS, Eng B, Patterson M, Walker L, Carcao MD, Olivieri NF, Chui DH. Hemoglobin H (Hb H) disease in Canada: molecular diagnosis and review of 116 cases. Am J Hematol. 2001 Sep; 68(1):11-5. PMID: 11559931.
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    138. Dean JA, Blanchette VS, Carcao MD, Stain AM, Sparling CR, Siekmann J, Turecek PL, Lillicrap D, Rand ML. von Willebrand disease in a pediatric-based population--comparison of type 1 diagnostic criteria and use of the PFA-100 and a von Willebrand factor/collagen-binding assay. Thromb Haemost. 2000 Sep; 84(3):401-9. PMID: 11019962.
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    139. Blanchette V, Carcao M. Approach to the investigation and management of immune thrombocytopenic purpura in children. Semin Hematol. 2000 Jul; 37(3):299-314. PMID: 10942224.
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    140. Carcao MD, Chang L, Poon A, Olivieri NF, Waye JS, Eng B, Patterson M, Chui DH. Compound heterozygosity for Hb S and Hb G-Copenhagen. Hemoglobin. 1999 Nov; 23(4):379-81. PMID: 10569728.
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    141. Blanchette V, Carcao M. Intravenous immunoglobulin G and anti-D as therapeutic interventions in immune thrombocytopenic purpura. Transfus Sci. 1998 Sep; 19(3):279-88. PMID: 10351140.
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    142. Carcao MD, Taylor GP, Greenberg ML, Bernstein ML, Champagne M, Hershon L, Baruchel S. Renal-cell carcinoma in children: a different disorder from its adult counterpart? Med Pediatr Oncol. 1998 Sep; 31(3):153-8. PMID: 9722897.
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    143. Carcao MD, Lau RC, Gupta A, Huerter H, Koren G, King SM. Sequential use of intravenous and oral acyclovir in the therapy of varicella in immunocompromised children. Pediatr Infect Dis J. 1998 Jul; 17(7):626-31. PMID: 9686730.
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    144. Carcao MD, Zipursky A, Butchart S, Leaker M, Blanchette VS. Short-course oral prednisone therapy in children presenting with acute immune thrombocytopenic purpura (ITP). Acta Paediatr Suppl. 1998 Jun; 424:71-4. PMID: 9736224.
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    145. Carcao MD, Blanchette VS, Dean JA, He L, Kern MA, Stain AM, Sparling CR, Stephens D, Ryan G, Freedman J, Rand ML. The Platelet Function Analyzer (PFA-100): a novel in-vitro system for evaluation of primary haemostasis in children. Br J Haematol. 1998 Apr; 101(1):70-3. PMID: 9576184.
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    146. Carcao M, Blaser SI, Grant RM, Weksberg R, Siegel-Bartelt J. MRI findings in macrocephaly-cutis marmorata telangiectatica congenita. Am J Med Genet. 1998 Mar 05; 76(2):165-7. PMID: 9511980.
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    147. Rand ML, Carcao MD, Blanchette VS. Use of the PFA-100 in the assessment of primary, platelet-related hemostasis in a pediatric setting. Semin Thromb Hemost. 1998; 24(6):523-9. PMID: 10066147.
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