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Eyal Grunebaum

TitleDiv Chief Immunology/Allergy
InstitutionThe Hospital for Sick Children
DepartmentImmunology & Allergy
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Liu Y, Budylowski P, Dong S, Li Z, Goroshko S, Leung LYT, Grunebaum E, Campisi P, Propst EJ, Wolter NE, Rini JM, Zia A, Ostrowski M, Ehrhardt GRA. SARS-CoV-2-Reactive Mucosal B Cells in the Upper Respiratory Tract of Uninfected Individuals. J Immunol. 2021 11 15; 207(10):2581-2588. PMID: 34607939.
      View in: PubMed
    2. Ke D, Lejtenyi D, Beaudette L, Ahmed E, McCusker C, Upton JEM, Chan ES, Clarke A, Grunebaum E, Mazer BD, Ben-Shoshan M. Short dosing intervals during oral challenge increase the risk of severe adverse reactions in children with milk allergy. J Allergy Clin Immunol Pract. 2021 10; 9(10):3829-3832.e1. PMID: 34126273.
      View in: PubMed
    3. Jangjoo M, Goodman SJ, Choufani S, Trost B, Scherer SW, Kelley E, Ayub M, Nicolson R, Georgiades S, Crosbie J, Schachar R, Anagnostou E, Grunebaum E, Weksberg R. An Epigenetically Distinct Subset of Children With Autism Spectrum Disorder Resulting From Differences in Blood Cell Composition. Front Neurol. 2021; 12:612817. PMID: 33935932.
      View in: PubMed
    4. Kashani P, Marwaha A, Feanny S, Kim VH, Atkinson AR, Leon-Ponte M, Mendoza-Londono R, Grunebaum E. Progressive decline of T and B cell numbers and function in a patient with CDC42 deficiency. Immunol Res. 2021 02; 69(1):53-58. PMID: 33405195.
      View in: PubMed
    5. Kuehn HS, Bernasconi A, Niemela JE, Almejun MB, Gallego WAF, Goel S, Stoddard JL, Sánchez RGP, Franco CAA, Oleastro M, Grunebaum E, Ballas Z, Cunningham-Rundles C, Fleisher TA, Franco JL, Danielian S, Rosenzweig SD. Correction to: A Nonsense N -Terminus NFKB2 Mutation Leading to Haploinsufficiency in a Patient with a Predominantly Antibody Deficiency. J Clin Immunol. 2020 Nov; 40(8):1102. PMID: 32901356.
      View in: PubMed
    6. Kuehn HS, Bernasconi A, Niemela JE, Almejun MB, Gallego WAF, Goel S, Stoddard JL, Sánchez RGP, Franco CAA, Oleastro M, Grunebaum E, Ballas Z, Cunningham-Rundles C, Fleisher TA, Franco JL, Danielian S, Rosenzweig SD. A Nonsense N -Terminus NFKB2 Mutation Leading to Haploinsufficiency in a Patient with a Predominantly Antibody Deficiency. J Clin Immunol. 2020 11; 40(8):1093-1101. PMID: 32813180.
      View in: PubMed
    7. Grunebaum E, Campbell N, Leon-Ponte M, Xu X, Chapdelaine H. Partial Purine Nucleoside Phosphorylase Deficiency Helps Determine Minimal Activity Required for Immune and Neurological Development. Front Immunol. 2020; 11:1257. PMID: 32695102.
      View in: PubMed
    8. Liu Y, Goroshko S, Leung LYT, Dong S, Khan S, Campisi P, Propst EJ, Wolter NE, Grunebaum E, Ehrhardt GRA. FCRL4 Is an Fc Receptor for Systemic IgA, but Not Mucosal Secretory IgA. J Immunol. 2020 07 15; 205(2):533-538. PMID: 32513851.
      View in: PubMed
    9. Kehar M, Grunebaum E, Jimenez-Rivera C, Mozer-Glassberg Y, Jamal A, Ng VL, Avitzur Y. Conversion from tacrolimus to sirolimus as a treatment modality in de novo allergies and immune-mediated disorders in pediatric liver transplant recipients. Pediatr Transplant. 2020 09; 24(6):e13737. PMID: 32428390.
      View in: PubMed
    10. Khan S, Liu Y, Ernst LM, Leung LYT, Budylowski P, Dong S, Campisi P, Propst EJ, Wolter NE, Grunebaum E, Ostrowski M, Ehrhardt GRA. Detection of Human CD38 Using Variable Lymphocyte Receptor (VLR) Tetramers. Cells. 2020 04 12; 9(4). PMID: 32290546.
      View in: PubMed
    11. Murguia-Favela L, Min W, Loves R, Leon-Ponte M, Grunebaum E. Comparison of elapegademase and pegademase in ADA-deficient patients and mice. Clin Exp Immunol. 2020 05; 200(2):176-184. PMID: 31989577.
      View in: PubMed
    12. Grunebaum E, Reid B, Naqvi A, Hershfield MS, Kim VH, Muller MP, Hicks LK, Lee E, Betschel S, Roifman CM. Morbidity in an adenosine deaminase-deficient patient during 27 years of enzyme replacement therapy. Clin Immunol. 2020 02; 211:108321. PMID: 31812707.
      View in: PubMed
    13. Starokadomskyy P, Wilton KM, Krzewski K, Lopez A, Sifuentes-Dominguez L, Overlee B, Chen Q, Ray A, Gil-Krzewska A, Peterson M, Kinch LN, Rohena L, Grunebaum E, Zinn AR, Grishin NV, Billadeau DD, Burstein E. NK cell defects in X-linked pigmentary reticulate disorder. JCI Insight. 2019 11 01; 4(21). PMID: 31672938.
      View in: PubMed
    14. Xu X, Negandhi J, Min W, Tsui M, Post M, Harrison RV, Grunebaum E. Early Enzyme Replacement Therapy Improves Hearing and Immune Defects in Adenosine Deaminase Deficient-Mice. Front Immunol. 2019; 10:416. PMID: 30918508.
      View in: PubMed
    15. Chan JTH, Liu Y, Khan S, St-Germain JR, Zou C, Leung LYT, Yang J, Shi M, Grunebaum E, Campisi P, Propst EJ, Holler T, Bar-Or A, Wither JE, Cairo CW, Moran MF, Palazzo AF, Cooper MD, Ehrhardt GRA. A tyrosine sulfation-dependent HLA-I modification identifies memory B cells and plasma cells. Sci Adv. 2018 11; 4(11):eaar7653. PMID: 30417091.
      View in: PubMed
    16. Grunebaum E, Avitzur Y. Liver-associated immune abnormalities. Autoimmun Rev. 2019 Jan; 18(1):15-20. PMID: 30408587.
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    17. Duan L, Grunebaum E. Immunosuppression for immunodeficiency: Getting smarter. J Allergy Clin Immunol. 2018 12; 142(6):1762-1764.e1. PMID: 30339850.
      View in: PubMed
    18. Park M, Xu X, Min W, Sugiman-Marangos SN, Beilhartz GL, Adams JJ, Sidhu SS, Grunebaum E, Melnyk RA. Intracellular Delivery of Human Purine Nucleoside Phosphorylase by Engineered Diphtheria Toxin Rescues Function in Target Cells. Mol Pharm. 2018 11 05; 15(11):5217-5226. PMID: 30212635.
      View in: PubMed
    19. Kohn DB, Hershfield MS, Puck JM, Aiuti A, Blincoe A, Gaspar HB, Notarangelo LD, Grunebaum E. Consensus approach for the management of severe combined immune deficiency caused by adenosine deaminase deficiency. J Allergy Clin Immunol. 2019 03; 143(3):852-863. PMID: 30194989.
      View in: PubMed
    20. Duan L, Grunebaum E. Hematological Malignancies Associated With Primary Immunodeficiency Disorders. Clin Immunol. 2018 09; 194:46-59. PMID: 29966714.
      View in: PubMed
    21. Kim VH, Pham-Huy A, Grunebaum E. Neutropenia among patients with adenosine deaminase deficiency. J Allergy Clin Immunol. 2019 01; 143(1):403-405. PMID: 29753815.
      View in: PubMed
    22. Liu Y, McDaniel JR, Khan S, Campisi P, Propst EJ, Holler T, Grunebaum E, Georgiou G, Ippolito GC, Ehrhardt GRA. Antibodies Encoded by FCRL4-Bearing Memory B Cells Preferentially Recognize Commensal Microbial Antigens. J Immunol. 2018 06 15; 200(12):3962-3969. PMID: 29703863.
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    23. Marcus N, Amir AZ, Grunebaum E, Dipchand A, Hebert D, Ng VL, Walters T, Avitzur Y. De Novo Allergy and Immune-Mediated Disorders Following Solid-Organ Transplantation-Prevalence, Natural History, and Risk Factors. J Pediatr. 2018 05; 196:154-160.e2. PMID: 29395171.
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    24. Kim VH, Reid B, Atkinson A, Upton J, Grunebaum E, Roifman CM. Long-term immune reconstitution after matched unrelated hematopoietic stem cell transplantation for immunodeficiency. J Allergy Clin Immunol. 2018 03; 141(3):1154-1157.e3. PMID: 29128672.
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    25. Scott O, Kim VH, Reid B, Pham-Huy A, Atkinson AR, Aiuti A, Grunebaum E. Long-Term Outcome of Adenosine Deaminase-Deficient Patients-a Single-Center Experience. J Clin Immunol. 2017 Aug; 37(6):582-591. PMID: 28748310.
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    26. Ovadia A, Dinur Schejter Y, Grunebaum E, Kim VH, Reid B, Schechter T, Pope E, Roifman CM. Hematopoietic stem cell transplantation for RelB deficiency. J Allergy Clin Immunol. 2017 10; 140(4):1199-1201.e3. PMID: 28552761.
      View in: PubMed
    27. Slack J, Albert MH, Balashov D, Belohradsky BH, Bertaina A, Bleesing J, Booth C, Buechner J, Buckley RH, Ouachée-Chardin M, Deripapa E, Drabko K, Eapen M, Feuchtinger T, Finocchi A, Gaspar HB, Ghosh S, Gillio A, Gonzalez-Granado LI, Grunebaum E, Güngör T, Heilmann C, Helminen M, Higuchi K, Imai K, Kalwak K, Kanazawa N, Karasu G, Kucuk ZY, Laberko A, Lange A, Mahlaoui N, Meisel R, Moshous D, Muramatsu H, Parikh S, Pasic S, Schmid I, Schuetz C, Schulz A, Schultz KR, Shaw PJ, Slatter MA, Sykora KW, Tamura S, Taskinen M, Wawer A, Wolska-Kusnierz B, Cowan MJ, Fischer A, Gennery AR. Outcome of hematopoietic cell transplantation for DNA double-strand break repair disorders. J Allergy Clin Immunol. 2018 01; 141(1):322-328.e10. PMID: 28392333.
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    28. Xu X, Tailor CS, Grunebaum E. Gene therapy for primary immune deficiencies: a Canadian perspective. Allergy Asthma Clin Immunol. 2017; 13:14. PMID: 28261277.
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    29. de la Morena MT, Leonard D, Torgerson TR, Cabral-Marques O, Slatter M, Aghamohammadi A, Chandra S, Murguia-Favela L, Bonilla FA, Kanariou M, Damrongwatanasuk R, Kuo CY, Dvorak CC, Meyts I, Chen K, Kobrynski L, Kapoor N, Richter D, DiGiovanni D, Dhalla F, Farmaki E, Speckmann C, Español T, Shcherbina A, Hanson IC, Litzman J, Routes JM, Wong M, Fuleihan R, Seneviratne SL, Small TN, Janda A, Bezrodnik L, Seger R, Raccio AG, Edgar JD, Chou J, Abbott JK, van Montfrans J, González-Granado LI, Bunin N, Kutukculer N, Gray P, Seminario G, Pasic S, Aquino V, Wysocki C, Abolhassani H, Dorsey M, Cunningham-Rundles C, Knutsen AP, Sleasman J, Costa Carvalho BT, Condino-Neto A, Grunebaum E, Chapel H, Ochs HD, Filipovich A, Cowan M, Gennery A, Cant A, Notarangelo LD, Roifman CM. Long-term outcomes of 176 patients with X-linked hyper-IgM syndrome treated with or without hematopoietic cell transplantation. J Allergy Clin Immunol. 2017 Apr; 139(4):1282-1292. PMID: 27697500.
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    30. Litvack ML, Wigle TJ, Lee J, Wang J, Ackerley C, Grunebaum E, Post M. Alveolar-like Stem Cell-derived Myb(-) Macrophages Promote Recovery and Survival in Airway Disease. Am J Respir Crit Care Med. 2016 06 01; 193(11):1219-29. PMID: 26730942.
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    31. Cicalese MP, Ferrua F, Castagnaro L, Pajno R, Barzaghi F, Giannelli S, Dionisio F, Brigida I, Bonopane M, Casiraghi M, Tabucchi A, Carlucci F, Grunebaum E, Adeli M, Bredius RG, Puck JM, Stepensky P, Tezcan I, Rolfe K, De Boever E, Reinhardt RR, Appleby J, Ciceri F, Roncarolo MG, Aiuti A. Update on the safety and efficacy of retroviral gene therapy for immunodeficiency due to adenosine deaminase deficiency. Blood. 2016 07 07; 128(1):45-54. PMID: 27129325.
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    32. Grunebaum E, Kim VH, Somers GR, Shammas A, Roifman CM. Bone marrow transplantation for monoallelic signal transducer and activator of transcription 1 deficiency. J Allergy Clin Immunol. 2016 08; 138(2):612-615.e1. PMID: 27061251.
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    33. Starokadomskyy P, Gemelli T, Rios JJ, Xing C, Wang RC, Li H, Pokatayev V, Dozmorov I, Khan S, Miyata N, Fraile G, Raj P, Xu Z, Xu Z, Ma L, Lin Z, Wang H, Yang Y, Ben-Amitai D, Orenstein N, Mussaffi H, Baselga E, Tadini G, Grunebaum E, Sarajlija A, Krzewski K, Wakeland EK, Yan N, de la Morena MT, Zinn AR, Burstein E. DNA polymerase-a regulates the activation of type I interferons through cytosolic RNA:DNA synthesis. Nat Immunol. 2016 May; 17(5):495-504. PMID: 27019227.
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    34. Yu C, Liu Y, Chan JTH, Tong J, Li Z, Shi M, Davani D, Parsons M, Khan S, Zhan W, Kyu S, Grunebaum E, Campisi P, Propst EJ, Jaye DL, Trudel S, Moran MF, Ostrowski M, Herrin BR, Lee FE, Sanz I, Cooper MD, Ehrhardt GR. Identification of human plasma cells with a lamprey monoclonal antibody. JCI Insight. 2016; 1(3). PMID: 27152361.
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    35. Zao JH, Schechter T, Liu WJ, Gerges S, Gassas A, Egeler RM, Grunebaum E, Dupuis LL. Performance of Busulfan Dosing Guidelines for Pediatric Hematopoietic Stem Cell Transplant Conditioning. Biol Blood Marrow Transplant. 2015 Aug; 21(8):1471-8. PMID: 25977229.
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    36. Faitelson Y, Grunebaum E. Hemophagocytic lymphohistiocytosis and primary immune deficiency disorders. Clin Immunol. 2014 Nov; 155(1):118-125. PMID: 25241079.
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    37. Dhanju R, Min W, Ackerley C, Cimpean L, Palaniyar N, Roifman CM, Grunebaum E. Pulmonary alveolar proteinosis in adenosine deaminase-deficient mice. J Allergy Clin Immunol. 2014 May; 133(5):1467-71, 1471.e1-4. PMID: 24439080.
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    38. Grunebaum E, Cohen A, Roifman CM. Recent advances in understanding and managing adenosine deaminase and purine nucleoside phosphorylase deficiencies. Curr Opin Allergy Clin Immunol. 2013 Dec; 13(6):630-8. PMID: 24113229.
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    39. Grunebaum E. A drop of prevention is worth a liter of cure: the case for newborn screening for severe T cell immune deficiency in Israel. Isr Med Assoc J. 2013 Aug; 15(8):445-6. PMID: 24079068.
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    40. Somech R, Lev A, Grisaru-Soen G, Shiran SI, Simon AJ, Grunebaum E. Purine nucleoside phosphorylase deficiency presenting as severe combined immune deficiency. Immunol Res. 2013 May; 56(1):150-4. PMID: 23371835.
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    41. Grunebaum E, Daneman A, Murguia-Favela L, Manson D, Kim VH, Roifman CM, Grunebaum M. Multiple osteochondromas following irradiation-containing conditioning in severe combined immunodeficiency. Br J Haematol. 2013 May; 161(3):446-8. PMID: 23384194.
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    42. Manson D, Diamond L, Oudjhane K, Hussain FB, Roifman C, Grunebaum E. Characteristic scapular and rib changes on chest radiographs of children with ADA-deficiency SCIDS in the first year of life. Pediatr Radiol. 2013 Mar; 43(5):589-92. PMID: 23179487.
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    43. Kim VH, Murguia L, Schechter T, Grunebaum E, Roifman CM. Emergency treatment for ? chain-associated protein of 70 kDa (ZAP70) deficiency. J Allergy Clin Immunol. 2013 Apr; 131(4):1233-5. PMID: 23141738.
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    44. Hassan A, Booth C, Brightwell A, Allwood Z, Veys P, Rao K, Hönig M, Friedrich W, Gennery A, Slatter M, Bredius R, Finocchi A, Cancrini C, Aiuti A, Porta F, Lanfranchi A, Ridella M, Steward C, Filipovich A, Marsh R, Bordon V, Al-Muhsen S, Al-Mousa H, Alsum Z, Al-Dhekri H, Al Ghonaium A, Speckmann C, Fischer A, Mahlaoui N, Nichols KE, Grunebaum E, Al Zahrani D, Roifman CM, Boelens J, Davies EG, Cavazzana-Calvo M, Notarangelo L, Gaspar HB. Outcome of hematopoietic stem cell transplantation for adenosine deaminase-deficient severe combined immunodeficiency. Blood. 2012 Oct 25; 120(17):3615-24; quiz 3626. PMID: 22791287.
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    45. Roifman CM, Somech R, Kavadas F, Pires L, Nahum A, Dalal I, Grunebaum E. Defining combined immunodeficiency. J Allergy Clin Immunol. 2012 Jul; 130(1):177-83. PMID: 22664165.
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    46. Mansouri A, Min W, Cole CJ, Josselyn SA, Henderson JT, van Eede M, Henkelman RM, Ackerley C, Grunebaum E, Roifman CM. Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice. Neurobiol Dis. 2012 Aug; 47(2):201-9. PMID: 22521465.
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    47. Grunebaum E, Cutz E, Roifman CM. Pulmonary alveolar proteinosis in patients with adenosine deaminase deficiency. J Allergy Clin Immunol. 2012 Jun; 129(6):1588-93. PMID: 22409989.
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    48. Papinazath T, Min W, Sujiththa S, Cohen A, Ackerley C, Roifman CM, Grunebaum E. Effects of purine nucleoside phosphorylase deficiency on thymocyte development. J Allergy Clin Immunol. 2011 Oct; 128(4):854-863.e1. PMID: 21868080.
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    49. Marcus N, Takada H, Law J, Cowan MJ, Gil J, Regueiro JR, Plaza Lopez de Sabando D, Lopez-Granados E, Dalal J, Friedrich W, Manfred H, Hanson IC, Grunebaum E, Shearer WT, Roifman CM. Hematopoietic stem cell transplantation for CD3d deficiency. J Allergy Clin Immunol. 2011 Nov; 128(5):1050-7. PMID: 21757226.
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    50. Barron MA, Makhija M, Hagen LE, Pencharz P, Grunebaum E, Roifman CM. Increased resting energy expenditure is associated with failure to thrive in infants with severe combined immunodeficiency. J Pediatr. 2011 Oct; 159(4):628-32.e1. PMID: 21592502.
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    51. Grunebaum E, Chung CT, Dadi H, Kim P, Brigida I, Ferrua F, Cicalese MP, Aiuti A, Roifman CM. Purine metabolism, immune reconstitution, and abdominal adipose tumor after gene therapy for adenosine deaminase deficiency. J Allergy Clin Immunol. 2011 Jun; 127(6):1417-9.e3. PMID: 21531016.
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    52. Grunebaum E, Roifman CM. Bone marrow transplantation using HLA-matched unrelated donors for patients suffering from severe combined immunodeficiency. Hematol Oncol Clin North Am. 2011 Feb; 25(1):63-73. PMID: 21236390.
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    53. Newell A, Dadi H, Goldberg R, Ngan BY, Grunebaum E, Roifman CM. Diffuse large B-cell lymphoma as presenting feature of Zap-70 deficiency. J Allergy Clin Immunol. 2011 Feb; 127(2):517-20. PMID: 21094993.
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    54. Al-Sukaiti N, Reid B, Lavi S, Al-Zaharani D, Atkinson A, Roifman CM, Grunebaum E. Safety and efficacy of measles, mumps, and rubella vaccine in patients with DiGeorge syndrome. J Allergy Clin Immunol. 2010 Oct; 126(4):868-9. PMID: 20810153.
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    55. Gassas A, Min W, Evans AW, Carter S, Sándor GK, Grunebaum E. Hyperbaric oxygen therapy as a sole agent is not immunosuppressant in a highly immunogenic mouse model. Bone Marrow Res. 2011; 2011:579268. PMID: 22046567.
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    56. Grunebaum E, Roifman CM. Bone marrow transplantation using HLA-matched unrelated donors for patients suffering from severe combined immunodeficiency. Immunol Allergy Clin North Am. 2010 Feb; 30(1):63-73. PMID: 20113887.
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    57. Somech R, Lai YH, Grunebaum E, Le Saux N, Cutz E, Roifman CM. Polyethylene glycol-modified adenosine deaminase improved lung disease but not liver disease in partial adenosine deaminase deficiency. J Allergy Clin Immunol. 2009 Oct; 124(4):848-50. PMID: 19665771.
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    58. Yu Y, Arora A, Min W, Roifman CM, Grunebaum E. EdU incorporation is an alternative non-radioactive assay to [(3)H]thymidine uptake for in vitro measurement of mice T-cell proliferations. J Immunol Methods. 2009 Oct 31; 350(1-2):29-35. PMID: 19647746.
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    59. Sauer AV, Mrak E, Hernandez RJ, Zacchi E, Cavani F, Casiraghi M, Grunebaum E, Roifman CM, Cervi MC, Ambrosi A, Carlucci F, Roncarolo MG, Villa A, Rubinacci A, Aiuti A. ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency. Blood. 2009 Oct 08; 114(15):3216-26. PMID: 19633200.
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    60. Lavoratore SR, Navarro OM, Grunebaum E, Ali M, Koo A, Schechter T, Gassas A, Doyle JJ, Lee Dupuis L. Cyclosporine-induced pain syndrome in a child undergoing hematopoietic stem cell transplant. Ann Pharmacother. 2009 Apr; 43(4):767-71. PMID: 19318596.
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    61. Nahum A, Reid B, Grunebaum E, Roifman CM. Matched unrelated bone marrow transplant for Omenn syndrome. Immunol Res. 2009; 44(1-3):25-34. PMID: 18854956.
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    62. Liao P, Toro A, Min W, Lee S, Roifman CM, Grunebaum E. Lentivirus gene therapy for purine nucleoside phosphorylase deficiency. J Gene Med. 2008 Dec; 10(12):1282-93. PMID: 18924118.
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    63. Grunebaum E, Bates A, Roifman CM. Omenn syndrome is associated with mutations in DNA ligase IV. J Allergy Clin Immunol. 2008 Dec; 122(6):1219-20. PMID: 18845326.
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    64. Somech R, Kavadas FD, Atkinson A, Grunebaum E, Roifman CM. High-dose methylprednisolone is effective in the management of acute graft-versus-host disease in severe combined immune deficiency. J Allergy Clin Immunol. 2008 Dec; 122(6):1215-6. PMID: 18672279.
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    65. Roifman CM, Zhang J, Atkinson A, Grunebaum E, Mandel K. Adenosine deaminase deficiency can present with features of Omenn syndrome. J Allergy Clin Immunol. 2008 Apr; 121(4):1056-8. PMID: 18243287.
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    66. Roifman CM, Somech R, Grunebaum E. Matched unrelated bone marrow transplant for T+ combined immunodeficiency. Bone Marrow Transplant. 2008 Jun; 41(11):947-52. PMID: 18264145.
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    67. Bulley SR, Benson L, Grunebaum E, Roifman CM. Cardiac chamber hypertrophy following hematopoietic stem cell transplantation for primary immunodeficiency. Biol Blood Marrow Transplant. 2008 Feb; 14(2):229-35. PMID: 18215783.
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    68. Somech R, Somers GR, Chitayat D, Grunebaum E, Atkinson A, Kolomietz E, Roifman CM. Fatal lung fibrosis associated with immunodeficiency and gonadal dysgenesis in 46XX sisters--a new syndrome. . 2008 Jan 01; 146A(1):8-14. PMID: 17937424.
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    69. Nofech-Mozes Y, Blaser SI, Kobayashi J, Grunebaum E, Roifman CM. Neurologic abnormalities in patients with adenosine deaminase deficiency. Pediatr Neurol. 2007 Sep; 37(3):218-21. PMID: 17765813.
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    70. Husain M, Grunebaum E, Naqvi A, Atkinson A, Ngan BY, Aiuti A, Roifman CM. Burkitt's lymphoma in a patient with adenosine deaminase deficiency-severe combined immunodeficiency treated with polyethylene glycol-adenosine deaminase. J Pediatr. 2007 Jul; 151(1):93-5. PMID: 17586199.
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    71. Roifman CM, Grunebaum E, Dalal I, Notarangelo L. Matched unrelated bone marrow transplant for severe combined immunodeficiency. Immunol Res. 2007; 38(1-3):191-200. PMID: 17917025.
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    72. Al-Jenaidi F, Makitie O, Grunebaum E, Sochett E. Parathyroid gland dysfunction in 22q11.2 deletion syndrome. Horm Res. 2007; 67(3):117-22. PMID: 17057408.
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    73. Guggenheim R, Somech R, Grunebaum E, Atkinson A, Roifman CM. Bone marrow transplantation for cartilage-hair-hypoplasia. Bone Marrow Transplant. 2006 Dec; 38(11):751-6. PMID: 17041608.
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    74. Toro A, Grunebaum E. TAT-mediated intracellular delivery of purine nucleoside phosphorylase corrects its deficiency in mice. J Clin Invest. 2006 Oct; 116(10):2717-26. PMID: 16964310.
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    75. Toro A, Paiva M, Ackerley C, Grunebaum E. Intracellular delivery of purine nucleoside phosphorylase (PNP) fused to protein transduction domain corrects PNP deficiency in vitro. Cell Immunol. 2006 Apr; 240(2):107-15. PMID: 16930574.
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    76. Grunebaum E, Mazzolari E, Porta F, Dallera D, Atkinson A, Reid B, Notarangelo LD, Roifman CM. Bone marrow transplantation for severe combined immune deficiency. JAMA. 2006 Feb 01; 295(5):508-18. PMID: 16449616.
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    77. Grunebaum E, Sharfe N, Roifman CM. Human T cell immunodeficiency: when signal transduction goes wrong. Immunol Res. 2006; 35(1-2):117-26. PMID: 17003514.
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    78. Carcao M, St Louis J, Poon MC, Grunebaum E, Lacroix S, Stain AM, Blanchette VS, Rivard GE. Rituximab for congenital haemophiliacs with inhibitors: a Canadian experience. Haemophilia. 2006 Jan; 12(1):7-18. PMID: 16409170.
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    79. Zhang J, Quintal L, Atkinson A, Williams B, Grunebaum E, Roifman CM. Novel RAG1 mutation in a case of severe combined immunodeficiency. Pediatrics. 2005 Sep; 116(3):e445-9. PMID: 16061569.
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    80. Grunebaum E, Zhang J, Roifman CM. Novel mutations and hot-spots in patients with purine nucleoside phosphorylase deficiency. Nucleosides Nucleotides Nucleic Acids. 2004 Oct; 23(8-9):1411-5. PMID: 15571269.
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    81. Dror Y, Grunebaum E, Hitzler J, Narendran A, Ye C, Tellier R, Edwards V, Freedman MH, Roifman CM. Purine nucleoside phosphorylase deficiency associated with a dysplastic marrow morphology. Pediatr Res. 2004 Mar; 55(3):472-7. PMID: 14711904.
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    82. Matalon ST, Blank M, Levy Y, Carp HJ, Arad A, Burek L, Grunebaum E, Sherer Y, Ornoy A, Refetoff S, Weiss RE, Rose NR, Shoenfeld Y. The pathogenic role of anti-thyroglobulin antibody on pregnancy: evidence from an active immunization model in mice. Hum Reprod. 2003 May; 18(5):1094-9. PMID: 12721190.
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    83. Grunebaum E, Blank M, Cohen S, Afek A, Kopolovic J, Meroni PL, Youinou P, Shoenfeld Y. The role of anti-endothelial cell antibodies in Kawasaki disease - in vitro and in vivo studies. Clin Exp Immunol. 2002 Nov; 130(2):233-40. PMID: 12390310.
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    84. Grunebaum E, Roifman CM. Gene abnormalities in patients with hemophagocytic lymphohistiocytosis. Isr Med Assoc J. 2002 May; 4(5):366-9. PMID: 12040827.
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    85. Grunebaum E, Levy Y, Shoenfeld Y. Novel aspects of hypogammaglobulinemic states: subcutaneous immunoglobulin treatment. Isr Med Assoc J. 2002 Apr; 4(4):288-9. PMID: 12001706.
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    86. Grunebaum E, Arpaia E, MacKenzie JJ, Fitzpatrick J, Ray PN, Roifman CM. A missense mutation in the SEDL gene results in delayed onset of X linked spondyloepiphyseal dysplasia in a large pedigree. J Med Genet. 2001 Jun; 38(6):409-11. PMID: 11424925.
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    87. Dalal I, Grunebaum E, Cohen A, Roifman CM. Two novel mutations in a purine nucleoside phosphorylase (PNP)-deficient patient. Clin Genet. 2001 Jun; 59(6):430-7. PMID: 11453975.
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    88. Renaudineau Y, Grunebaum E, Krause I, Praprotnik S, Revelen R, Youinou P, Blanks M, Gilburd B, Sherer Y, Luderschmidt C, Eldor A, Weksler B, Gershwin EM, Shoenfeld Y. Anti-endothelial cell antibodies (AECA) in systemic sclerosis--increased sensitivity using different endothelial cell substrates and association with other autoantibodies. Autoimmunity. 2001 May; 33(3):171-9. PMID: 11683377.
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    89. Mandel K, Grunebaum E, Benson L. Noncompaction of the myocardium associated with Roifman syndrome. Cardiol Young. 2001 Mar; 11(2):240-3. PMID: 11293748.
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    90. Grunebaum E, Roifman CM. Signal-transduction defects in T cells. Clin Rev Allergy Immunol. 2001 Feb; 20(1):27-42. PMID: 11269226.
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    91. Grunebaum E, Zhang J, Dadi H, Roifman CM. Haemophagocytic lymphohistiocytosis in X-linked severe combined immunodeficiency. Br J Haematol. 2000 Mar; 108(4):834-7. PMID: 10792291.
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    92. Grunebaum E, Lavi S. The role of food and inhaled allergens in atopic dermatitis. J Cutan Med Surg. 1999 Feb; 3 Suppl 2:S2-24-S2-28. PMID: 10071362.
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    93. Grunebaum E, Renaudineau E, Shoenfeld Y. [Anti-endothelial cell antibodies--clinical significance]. Harefuah. 1997 Nov 16; 133(10):458-62. PMID: 9418321.
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    94. Shoenfeld Y, Grunebaum E, Laufer M, Zurgil N, Bakimer R, Lunderschmidt A, Valentini G, Tirri G, Blank M. Anti-topoisomerase-I and clinical findings in systemic sclerosis (scleroderma). Isr J Med Sci. 1996 Jul; 32(7):537-42. PMID: 8756980.
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    95. Grunebaum E, Chaitchuk S, Shoenfeld Y. [Pancreatic carcinoma, sex hormones receptors and treatment with tamoxifen]. Harefuah. 1991 Mar 15; 120(6):340-3. PMID: 1879772.
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    96. Grunebaum E, Amir J, Merlob P, Mimouni M, Varsano I. Breast mild jaundice: natural history, familial incidence and late neurodevelopmental outcome of the infant. Eur J Pediatr. 1991 Feb; 150(4):267-70. PMID: 2029918.
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    97. Grunebaum E, Malatzky-Goshen E, Shoenfeld Y. Natural killer cells and autoimmunity. Immunol Res. 1989; 8(4):292-304. PMID: 2687403.
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