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Valerie Langlois

TitleStaff Nephrologist
InstitutionThe Hospital for Sick Children
DepartmentNephrology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lara-Jacobo LR, Willard B, Wallace SJ, Langlois VS. Cytochrome P450 1A transcript is a suitable biomarker of both exposure and response to diluted bitumen in developing frog embryos. Environ Pollut. 2018 Dec 15; 246:501-508. PMID: 30583158.
      View in: PubMed
    2. McDonnell D, Madison BN, Baillon L, Wallace SJ, Brown SR, Hodson PV, Langlois VS. Comparative toxicity of two diluted bitumens to developing yellow perch (Perca flavescens). Sci Total Environ. 2019 Mar 10; 655:977-985. PMID: 30577145.
      View in: PubMed
    3. Alkandari O, Nguyen L, Hebert D, Langlois V, Jawa NA, Parekh RS, Robinson LA. Acute Kidney Injury in Children with Kidney Transplantation. Clin J Am Soc Nephrol. 2018 Nov 07; 13(11):1721-1729. PMID: 30242029.
      View in: PubMed
    4. Alsaadi FM, Madison BN, Brown RS, Hodson PV, Langlois VS. Morphological and molecular effects of two diluted bitumens on developing fathead minnow (Pimephales promelas). Aquat Toxicol. 2018 Nov; 204:107-116. PMID: 30243048.
      View in: PubMed
    5. Bissegger S, Pineda Castro MA, Yargeau V, Langlois VS. Phthalates modulate steroid 5-reductase transcripts in the Western clawed frog embryo. Comp Biochem Physiol C Toxicol Pharmacol. 2018 Nov; 213:39-46. PMID: 30055282.
      View in: PubMed
    6. Campbell DEK, Langlois VS. Thyroid hormones and androgens differentially regulate gene expression in testes and ovaries of sexually mature Silurana tropicalis. Gen Comp Endocrinol. 2018 10 01; 267:172-182. PMID: 29990494.
      View in: PubMed
    7. Thomson P, Langlois VS. Developmental profiles of progesterone receptor transcripts and molecular responses to gestagen exposure during Silurana tropicalis early development. Gen Comp Endocrinol. 2018 09 01; 265:4-14. PMID: 29778442.
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    8. Rumman RK, Matsuda-Abedini M, Langlois V, Radhakrishnan S, Lorenzo AJ, Amaral J, Mertens L, Parekh RS. Management and Outcomes of Childhood Renal Artery Stenosis and Middle Aortic Syndrome. Am J Hypertens. 2018 May 07; 31(6):687-695. PMID: 29373648.
      View in: PubMed
    9. Langlois V, Trinh VH, Lusso C, Perrot C, Chateau X, Khidas Y, Pitois O. Permeability of solid foam: Effect of pore connections. Phys Rev E. 2018 May; 97(5-1):053111. PMID: 29906824.
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    10. Leclercq M, Le Besnerais M, Langlois V, Girszyn N, Benhamou Y, Ngo C, Levesque H, Muraine M, Gueudry J. Tocilizumab for the treatment of birdshot uveitis that failed interferon alpha and anti-tumor necrosis factor-alpha therapy: two cases report and literature review. Clin Rheumatol. 2018 Mar; 37(3):849-853. PMID: 29397459.
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    11. Wallace SJ, de Solla SR, Thomas PJ, Harner T, Eng A, Langlois VS. Airborne polycyclic aromatic compounds contribute to the induction of the tumour-suppressing P53 pathway in wild double-crested cormorants. Ecotoxicol Environ Saf. 2018 Apr 15; 150:176-189. PMID: 29276953.
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    12. Alsaadi F, Hodson PV, Langlois VS. An Embryonic Field of Study: The Aquatic Fate and Toxicity of Diluted Bitumen. Bull Environ Contam Toxicol. 2018 Jan; 100(1):8-13. PMID: 29243210.
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    13. Zhang J, Wallace SJ, Shiu MY, Smith I, Rhind SG, Langlois VS. Human hair follicle transcriptome profiling: a minimally invasive tool to assess molecular adaptations upon low-volume, high-intensity interval training. Physiol Rep. 2017 Dec; 5(23). PMID: 29212859.
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    14. Zhang J, Knight R, Wang Y, Sawyer TW, Martyniuk CJ, Langlois VS. Comprehensive assessment of shockwave intensity: Transcriptomic biomarker discovery for primary blast-induced mild traumatic brain injury using the mammalian hair follicle. Brain Inj. 2018; 32(1):123-134. PMID: 29157017.
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    15. Weiss MJ, Hornby L, Rochwerg B, van Manen M, Dhanani S, Sivarajan VB, Appleby A, Bennett M, Buchman D, Farrell C, Goldberg A, Greenberg R, Singh R, Nakagawa TA, Witteman W, Barter J, Beck A, Coughlin K, Conradi A, Cupido C, Dawson R, Dipchand A, Freed D, Hornby K, Langlois V, Mack C, Mahoney M, Manhas D, Tomlinson C, Zavalkoff S, Shemie SD. Canadian Guidelines for Controlled Pediatric Donation After Circulatory Determination of Death-Summary Report. Pediatr Crit Care Med. 2017 Nov; 18(11):1035-1046. PMID: 28925929.
      View in: PubMed
    16. Campbell DEK, Langlois VS. Expression of sf1 and dax-1 are regulated by thyroid hormones and androgens during Silurana tropicalis early development. Gen Comp Endocrinol. 2018 04 01; 259:34-44. PMID: 29107601.
      View in: PubMed
    17. Alkandari O, Hebert D, Langlois V, Robinson LA, Parekh RS. Validation of serum creatinine-based formulae in pediatric renal transplant recipients. Pediatr Res. 2017 Dec; 82(6):1000-1006. PMID: 28846672.
      View in: PubMed
    18. Rumman RK, Slorach C, Hui W, Matsuda-Abedini M, Langlois V, Radhakrishnan S, Lorenzo AJ, Amaral J, Mertens L, Parekh RS. Cardiovascular Structure and Function in Children With Middle Aortic Syndrome and Renal Artery Stenosis. Hypertension. 2017 12; 70(6):1193-1200. PMID: 28974566.
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    19. Chanchlani R, Thorner P, Radhakrishnan S, Hebert D, Langlois V, Arora S, Barth D, Cattran D, Kirschfink M, Licht C. Long-term Eculizumab Therapy in a Child With Refractory Immune Complex-Mediated Membranoproliferative Glomerulonephritis. Kidney Int Rep. 2018 Mar; 3(2):482-485. PMID: 29725653.
      View in: PubMed
    20. Madison BN, Hodson PV, Langlois VS. Cold Lake Blend diluted bitumen toxicity to the early development of Japanese medaka. Environ Pollut. 2017 Jun; 225:579-586. PMID: 28336089.
      View in: PubMed
    21. Borges K, Sibbald C, Hussain-Shamsy N, Vasilevska-Ristovska J, Banh T, Patel V, Brooke J, Piekut M, Reddon M, Aitken-Menezes K, McNaughton A, Pearl RJ, Langlois V, Radhakrishnan S, Licht CPB, Piscione TD, Levin L, Noone D, Hebert D, Parekh RS. Parental Health Literacy and Outcomes of Childhood Nephrotic Syndrome. Pediatrics. 2017 Mar; 139(3). PMID: 28213606.
      View in: PubMed
    22. Langlois V, Marie I. [Antineutrophil cytoplasmic antibodies associated with infective endocarditis: Literature review]. Rev Med Interne. 2017 Jul; 38(7):450-457. PMID: 28131439.
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    23. Martin JD, Colson TL, Langlois VS, Metcalfe CD. Biomarkers of exposure to nanosilver and silver accumulation in yellow perch (Perca flavescens). Environ Toxicol Chem. 2017 05; 36(5):1211-1220. PMID: 27699838.
      View in: PubMed
    24. Miranda S, Le Besnerais M, Langlois V, Benhamou Y, Lévesque H. [Erythromelalgia: Diagnosis and therapeutic approach]. Rev Med Interne. 2017 Mar; 38(3):176-180. PMID: 27639908.
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    25. Banh TH, Hussain-Shamsy N, Patel V, Vasilevska-Ristovska J, Borges K, Sibbald C, Lipszyc D, Brooke J, Geary D, Langlois V, Reddon M, Pearl R, Levin L, Piekut M, Licht CP, Radhakrishnan S, Aitken-Menezes K, Harvey E, Hebert D, Piscione TD, Parekh RS. Ethnic Differences in Incidence and Outcomes of Childhood Nephrotic Syndrome. Clin J Am Soc Nephrol. 2016 10 07; 11(10):1760-1768. PMID: 27445165.
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    26. Mathieu-Denoncourt J, Martyniuk CJ, Loughery JR, Yargeau V, de Solla SR, Langlois VS. Lethal and sublethal effects of phthalate diesters in Silurana tropicalis larvae. Environ Toxicol Chem. 2016 10; 35(10):2511-2522. PMID: 26924002.
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    27. Mathieu-Denoncourt J, Wallace SJ, de Solla SR, Langlois VS. Influence of Lipophilicity on the Toxicity of Bisphenol A and Phthalates to Aquatic Organisms. Bull Environ Contam Toxicol. 2016 Jul; 97(1):4-10. PMID: 27169527.
      View in: PubMed
    28. Langlois V, Nassarmadji K, Célestin S, Tuech JJ, Bernet J, Lévesque H, Grémain V, Marie I. [Thigh cutaneous lesions]. Rev Med Interne. 2016 Nov; 37(11):782-784. PMID: 27016278.
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    29. Borges K, Vasilevska-Ristovska J, Hussain-Shamsy N, Patel V, Banh T, Hebert D, Pearl RJ, Radhakrishnan S, Piscione TD, Licht CP, Langlois V, Levin L, Strug L, Parekh RS. Parental attitudes to genetic testing differ by ethnicity and immigration in childhood nephrotic syndrome: a cross-sectional study. Can J Kidney Health Dis. 2016; 3:16. PMID: 26998310; PMCID: PMC4797354.
    30. Grémain V, Richard L, Langlois V, Marie I. Imaging in central pontine myelonolysis: animals in the brain. QJM. 2016 Jun; 109(6):431-2. PMID: 26976949.
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    31. Bissegger S, Langlois VS. Androgens modulate gene expression and specific DNA methylation pattern of steroid 5a-reductases in the frog Silurana tropicalis. Gen Comp Endocrinol. 2016 08 01; 234:123-32. PMID: 26987288.
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    32. Crump D, Farhat A, Chiu S, Williams KL, Jones SP, Langlois VS. Use of a Novel Double-Crested Cormorant ToxChip PCR Array and the EROD Assay to Determine Effects of Environmental Contaminants in Primary Hepatocytes. Environ Sci Technol. 2016 Mar 15; 50(6):3265-74. PMID: 26894911.
      View in: PubMed
    33. Balakrishnan VK, Shirin S, Aman AM, de Solla SR, Mathieu-Denoncourt J, Langlois VS. Genotoxic and carcinogenic products arising from reductive transformations of the azo dye, Disperse Yellow 7. Chemosphere. 2016 Mar; 146:206-15. PMID: 26735719.
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    34. Sellers EA, Hadjiyannakis S, Amed S, Dart AB, Dyck RF, Hamilton J, Langlois V, Panagiotopoulos C, Dean HJ. Persistent Albuminuria in Children with Type 2 Diabetes: A Canadian Paediatric Surveillance Program Study. J Pediatr. 2016 Jan; 168:112-7. PMID: 26470688.
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    35. Zhang J, Koch I, Gibson LA, Loughery JR, Martyniuk CJ, Button M, Caumette G, Reimer KJ, Cullen WR, Langlois VS. Transcriptomic Responses During Early Development Following Arsenic Exposure in Western Clawed Frogs, Silurana tropicalis. Toxicol Sci. 2015 Dec; 148(2):603-17. PMID: 26427749.
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    36. Gibson LA, Koch I, Reimer KJ, Cullen WR, Langlois VS. Life cycle exposure of the frog Silurana tropicalis to arsenate: Steroid- and thyroid hormone-related genes are differently altered throughout development. Gen Comp Endocrinol. 2016 08 01; 234:133-41. PMID: 26393310.
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    37. Madison BN, Hodson PV, Langlois VS. Diluted bitumen causes deformities and molecular responses indicative of oxidative stress in Japanese medaka embryos. Aquat Toxicol. 2015 Aug; 165:222-30. PMID: 26118968.
      View in: PubMed
    38. Koch I, Zhang J, Button M, Gibson LA, Caumette G, Langlois VS, Reimer KJ, Cullen WR. Arsenic(+3) and DNA methyltransferases, and arsenic speciation in tadpole and frog life stages of western clawed frogs (Silurana tropicalis) exposed to arsenate. Metallomics. 2015 Aug; 7(8):1274-84. PMID: 26067210.
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    39. Mathieu-Denoncourt J, de Solla SR, Langlois VS. Chronic exposures to monomethyl phthalate in Western clawed frogs. Gen Comp Endocrinol. 2015 Aug 01; 219:53-63. PMID: 25662408.
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    40. Rumman RK, Nickel C, Matsuda-Abedini M, Lorenzo AJ, Langlois V, Radhakrishnan S, Amaral J, Mertens L, Parekh RS. Disease Beyond the Arch: A Systematic Review of Middle Aortic Syndrome in Childhood. Am J Hypertens. 2015 Jul; 28(7):833-46. PMID: 25631383.
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    41. Mathieu-Denoncourt J, Wallace SJ, de Solla SR, Langlois VS. Plasticizer endocrine disruption: Highlighting developmental and reproductive effects in mammals and non-mammalian aquatic species. Gen Comp Endocrinol. 2015 Aug 01; 219:74-88. PMID: 25448254.
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    42. Radhakrishnan S, Chanchlani R, Connolly B, Langlois V. Pre-procedure desmopressin acetate to reduce bleeding in renal failure: does it really work? Nephron Clin Pract. 2014; 128(1-2):45-8. PMID: 25373723.
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    43. Castañeda Cortés DC, Langlois VS, Fernandino JI. Crossover of the hypothalamic pituitary-adrenal/interrenal, -thyroid, and -gonadal axes in testicular development. Front Endocrinol (Lausanne). 2014; 5:139. PMID: 25221542; PMCID: PMC4145579.
    44. Zhang J, Carnduff L, Norman G, Josey T, Wang Y, Sawyer TW, Martyniuk CJ, Langlois VS. Transcriptional profiling in rat hair follicles following simulated Blast insult: a new diagnostic tool for traumatic brain injury. PLoS One. 2014; 9(8):e104518. PMID: 25136963; PMCID: PMC4138085.
    45. Gibson LA, Lavoie RA, Bissegger S, Campbell LM, Langlois VS. A positive correlation between mercury and oxidative stress-related gene expression (GPX3 and GSTM3) is measured in female Double-crested Cormorant blood. Ecotoxicology. 2014 Aug; 23(6):1004-14. PMID: 24788667.
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    46. Flood DE, Langlois VS. Crosstalk between the thyroid hormone and androgen axes during reproductive development in Silurana tropicalis. Gen Comp Endocrinol. 2014 Jul 01; 203:232-40. PMID: 24713448.
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    47. Langlois V, Jia X. Acoustic probing of elastic behavior and damage in weakly cemented granular media. Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Feb; 89(2):023206. PMID: 25353594.
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    48. Langlois V, Armengol G, Girszyn N, Lepileur L, Armengol-Debeir L, Benhamou Y, Lévesque H. [Multiple intra-abdominal nodules]. Rev Med Interne. 2014 Dec; 35(12):840-2. PMID: 24503384.
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    49. Vergnol G, Renard E, Haroun F, Guerin P, Seron A, Bureau C, Loirand G, Langlois V. Electrografting of a biodegradable layer as a primer adhesion coating onto a metallic stent: in vitro and in vivo evaluations. J Mater Sci Mater Med. 2013 Dec; 24(12):2729-39. PMID: 23904056.
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    50. Versace DL, Ramier J, Grande D, Andaloussi SA, Dubot P, Hobeika N, Malval JP, Lalevee J, Renard E, Langlois V. Versatile photochemical surface modification of biopolyester microfibrous scaffolds with photogenerated silver nanoparticles for antibacterial activity. Adv Healthc Mater. 2013 Jul; 2(7):1008-18. PMID: 23299982.
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    51. Radhakrishnan S, Lunn A, Kirschfink M, Thorner P, Hebert D, Langlois V, Pluthero F, Licht C. Eculizumab and refractory membranoproliferative glomerulonephritis. N Engl J Med. 2012 Mar 22; 366(12):1165-6. PMID: 22435384.
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    52. Frieling ML, Williams A, Al Shareef T, Kala G, Teh JC, Langlois V, Allen UD, Hebert D, Robinson LA. Novel influenza (H1N1) infection in pediatric renal transplant recipients: a single center experience. Pediatr Transplant. 2012 Mar; 16(2):123-30. PMID: 21923887.
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    53. Hayes TB, Anderson LL, Beasley VR, de Solla SR, Iguchi T, Ingraham H, Kestemont P, Kniewald J, Kniewald Z, Langlois VS, Luque EH, McCoy KA, Muñoz-de-Toro M, Oka T, Oliveira CA, Orton F, Ruby S, Suzawa M, Tavera-Mendoza LE, Trudeau VL, Victor-Costa AB, Willingham E. Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes. J Steroid Biochem Mol Biol. 2011 Oct; 127(1-2):64-73. PMID: 21419222; PMCID: PMC4303243.
    54. Langlois VS, Duarte-Guterman P, Trudeau VL. Expression profiles of reproduction- and thyroid hormone-related transcripts in the brains of chemically-induced intersex frogs. Sex Dev. 2011; 5(1):26-32. PMID: 21212651.
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    55. Neuhaus TJ, Langlois V, Licht C. Behavioural abnormalities in children with nephrotic syndrome--an underappreciated complication of a standard treatment? Nephrol Dial Transplant. 2010 Aug; 25(8):2397-9. PMID: 20573807.
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    56. Chaturvedi S, Licht C, Langlois V. Hemolytic uremic syndrome caused by Bordetella pertussis infection. Pediatr Nephrol. 2010 Jul; 25(7):1361-4. PMID: 20145955.
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    57. Duarte-Guterman P, Langlois VS, Hodgkinson K, Pauli BD, Cooke GM, Wade MG, Trudeau VL. The aromatase inhibitor fadrozole and the 5-reductase inhibitor finasteride affect gonadal differentiation and gene expression in the frog Silurana tropicalis. Sex Dev. 2009; 3(6):333-41. PMID: 20130388.
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    58. Anthony SJ, Hebert D, Todd L, Korus M, Langlois V, Pool R, Robinson LA, Williams A, Pollock-BarZiv SM. Child and parental perspectives of multidimensional quality of life outcomes after kidney transplantation. Pediatr Transplant. 2010 Mar; 14(2):249-56. PMID: 19686446.
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    59. Chavhan G, Daneman A, Moineddin R, Lim R, Langlois V, Traubici J. Renal pyramid echogenicity in ureteropelvic junction obstruction: correlation between altered echogenicity and differential renal function. Pediatr Radiol. 2008 Oct; 38(10):1068-73. PMID: 18633607.
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    60. Croteau MC, Renner VE, Archibald F, Langlois VS, Cahn J, Ridal J, Trudeau VL, Lean DR. Investigation of pathogenic Escherichia coli and microbial pathogens in pulp and paper mill biosolids. Water Environ Res. 2007 Sep; 79(9):1050-6. PMID: 17910375.
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    61. Waters A, Langlois V, Thorner P, Geary D. Atypical p-ANCA is not a poor prognostic marker in Postinfectious Glomerulonephritis. Pediatr Nephrol. 2007 Sep; 22(9):1383-6. PMID: 17479299.
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    62. Alexander RT, Langlois V, Tellier R, Robinson L, Hébert D. The prevalence of BK viremia and urinary viral shedding in a pediatric renal transplant population: a single-center retrospective analysis. Pediatr Transplant. 2006 Aug; 10(5):586-92. PMID: 16856995.
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    63. Sweeney C, Geary DF, Hebert D, Robinson L, Langlois V. Outpatient pediatric renal transplant biopsy--is it safe? Pediatr Transplant. 2006 Mar; 10(2):159-61. PMID: 16573600.
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    64. Durkan A, Menascu S, Langlois V. Isolated abducens nerve palsy in hemolytic uremic syndrome. Pediatr Nephrol. 2004 Aug; 19(8):915-6. PMID: 15185136.
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    65. Pantazaki AA, Tambaka MG, Langlois V, Guerin P, Kyriakidis DA. Polyhydroxyalkanoate (PHA) biosynthesis in Thermus thermophilus: purification and biochemical properties of PHA synthase. Mol Cell Biochem. 2003 Dec; 254(1-2):173-83. PMID: 14674696.
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    66. Thouvenin M, Langlois V, Briandet R, Langlois JY, Guerin PH, Peron JJ, Haras D, Vallee-Rehel K. Study of erodable paint properties involved in antifouling activity. Biofouling. 2003 Jun; 19(3):177-86. PMID: 14619286.
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    67. Langlois V, Geary D, Murray L, Champoux S, Hébert D, Goodyer P. Polyuria and proteinuria in cystinosis have no impact on renal transplantation. A report of the North American Pediatric Renal Transplant Cooperative Study. Pediatr Nephrol. 2000 Nov; 15(1-2):7-10. PMID: 11095001.
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    68. Jeanbat-Mimaud V, Barbaud C, Caruelle JP, Barritault D, Cammas-Marion S, Langlois V, Guerin P. Bioactive functionalized polymer of malic acid for bone repair and muscle regeneration. J Biomater Sci Polym Ed. 2000; 11(9):979-91. PMID: 11211090.
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    69. Langlois V, Bernard C, Scheinman SJ, Thakker RV, Cox JP, Goodyer PR. Clinical features of X-linked nephrolithiasis in childhood. Pediatr Nephrol. 1998 Oct; 12(8):625-9. PMID: 9811383.
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    70. Bear MM, Monne C, Robic D, Campion G, Langlois V, Rimbault A, Bourbouze R, Guerin P. Synthesis and polymerization of benzyl (3R,4R)-3-methylmalolactonate via enzymatic preparation of the chiral precursor. Chirality. 1998; 10(8):727-33. PMID: 9803528.
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