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Christopher Pearson

TitleSenior Scientist/Full Professor
InstitutionThe Hospital for Sick Children
DepartmentGenetics and Genome Biology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mohiuddin M, Rahman MM, Sale JE, Pearson CE. CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs. Nucleic Acids Res. 2019 Jan 18. PMID: 30657944.
      View in: PubMed
    2. Shuen AY, Lanni S, Panigrahi GB, Edwards M, Yu L, Campbell BB, Mandel A, Zhang C, Zhukova N, Alharbi M, Bernstein M, Bowers DC, Carroll S, Cole KA, Constantini S, Crooks B, Dvir R, Farah R, Hijiya N, George B, Laetsch TW, Larouche V, Lindhorst S, Luiten RC, Magimairajan V, Mason G, Mason W, Mordechai O, Mushtaq N, Nicholas G, Oren M, Palma L, Pedroza LA, Ramdas J, Samuel D, Wolfe Schneider K, Seeley A, Semotiuk K, Shamvil A, Sumerauer D, Toledano H, Tomboc P, Wierman M, Van Damme A, Lee YY, Zapotocky M, Bouffet E, Durno C, Aronson M, Gallinger S, Foulkes WD, Malkin D, Tabori U, Pearson CE. Functional Repair Assay for the Diagnosis of Constitutional Mismatch Repair Deficiency From Non-Neoplastic Tissue. J Clin Oncol. 2019 Jan 04; JCO1800474. PMID: 30608896.
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    3. Zamiri B, Mirceta M, Abu-Ghazalah R, Wold MS, Pearson CE, Macgregor RB. Stress-induced acidification may contribute to formation of unusual structures in C9orf72-repeats. Biochim Biophys Acta Gen Subj. 2018 06; 1862(6):1482-1491. PMID: 29550431.
      View in: PubMed
    4. Alniss H, Zamiri B, Khalaj M, Pearson CE, Macgregor RB. Thermodynamic and spectroscopic investigations of TMPyP4 association with guanine- and cytosine-rich DNA and RNA repeats of C9orf72. Biochem Biophys Res Commun. 2018 Jan 22; 495(4):2410-2417. PMID: 29274339.
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    5. Ishiguro T, Sato N, Ueyama M, Fujikake N, Sellier C, Kanegami A, Tokuda E, Zamiri B, Gall-Duncan T, Mirceta M, Furukawa Y, Yokota T, Wada K, Taylor JP, Pearson CE, Charlet-Berguerand N, Mizusawa H, Nagai Y, Ishikawa K. Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31. Neuron. 2017 Apr 05; 94(1):108-124.e7. PMID: 28343865.
      View in: PubMed
    6. Barbé L, Lanni S, López-Castel A, Franck S, Spits C, Keymolen K, Seneca S, Tomé S, Miron I, Letourneau J, Liang M, Choufani S, Weksberg R, Wilson MD, Sedlacek Z, Gagnon C, Musova Z, Chitayat D, Shannon P, Mathieu J, Sermon K, Pearson CE. CpG Methylation, a Parent-of-Origin Effect for Maternal-Biased Transmission of Congenital Myotonic Dystrophy. Am J Hum Genet. 2017 Mar 02; 100(3):488-505. PMID: 28257691.
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    7. Slean MM, Panigrahi GB, Castel AL, Pearson AB, Tomkinson AE, Pearson CE. Absence of MutSß leads to the formation of slipped-DNA for CTG/CAG contractions at primate replication forks. DNA Repair (Amst). 2016 06; 42:107-18. PMID: 27155933.
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    8. Schmidt MH, Pearson CE. Disease-associated repeat instability and mismatch repair. DNA Repair (Amst). 2016 Feb; 38:117-26. PMID: 26774442.
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    9. Kansal R, Li X, Shen J, Samuel D, Laningham F, Lee H, Panigrahi GB, Shuen A, Kantarci S, Dorrani N, Reiss J, Shintaku P, Deignan JL, Strom SP, Pearson CE, Vilain E, Grody WW. An infant with MLH3 variants, FOXG1-duplication and multiple, benign cranial and spinal tumors: A clinical exome sequencing study. Genes Chromosomes Cancer. 2016 Feb; 55(2):131-42. PMID: 26542077.
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    10. Zamiri B, Mirceta M, Bomsztyk K, Macgregor RB, Pearson CE. Quadruplex formation by both G-rich and C-rich DNA strands of the C9orf72 (GGGGCC)8•(GGCCCC)8 repeat: effect of CpG methylation. Nucleic Acids Res. 2015 Nov 16; 43(20):10055-64. PMID: 26432832; PMCID: PMC4787773.
    11. Shlien A, Campbell BB, de Borja R, Alexandrov LB, Merico D, Wedge D, Van Loo P, Tarpey PS, Coupland P, Behjati S, Pollett A, Lipman T, Heidari A, Deshmukh S, Avitzur N, Meier B, Gerstung M, Hong Y, Merino DM, Ramakrishna M, Remke M, Arnold R, Panigrahi GB, Thakkar NP, Hodel KP, Henninger EE, Göksenin AY, Bakry D, Charames GS, Druker H, Lerner-Ellis J, Mistry M, Dvir R, Grant R, Elhasid R, Farah R, Taylor GP, Nathan PC, Alexander S, Ben-Shachar S, Ling SC, Gallinger S, Constantini S, Dirks P, Huang A, Scherer SW, Grundy RG, Durno C, Aronson M, Gartner A, Meyn MS, Taylor MD, Pursell ZF, Pearson CE, Malkin D, Futreal PA, Stratton MR, Bouffet E, Hawkins C, Campbell PJ, Tabori U. Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers. Nat Genet. 2015 Mar; 47(3):257-62. PMID: 25642631.
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    12. Trang H, Stanley SY, Thorner P, Faghfoury H, Schulze A, Hawkins C, Pearson CE, Yoon G. Massive CAG repeat expansion and somatic instability in maternally transmitted infantile spinocerebellar ataxia type 7. JAMA Neurol. 2015 Feb; 72(2):219-23. PMID: 25506882.
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    13. Reddy K, Schmidt MH, Geist JM, Thakkar NP, Panigrahi GB, Wang YH, Pearson CE. Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability. Nucleic Acids Res. 2014; 42(16):10473-87. PMID: 25147206; PMCID: PMC4176329.
    14. Martins S, Pearson CE, Coutinho P, Provost S, Amorim A, Dubé MP, Sequeiros J, Rouleau GA. Modifiers of (CAG)(n) instability in Machado-Joseph disease (MJD/SCA3) transmissions: an association study with DNA replication, repair and recombination genes. Hum Genet. 2014 Oct; 133(10):1311-8. PMID: 25026993.
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    15. Zamiri B, Reddy K, Macgregor RB, Pearson CE. TMPyP4 porphyrin distorts RNA G-quadruplex structures of the disease-associated r(GGGGCC)n repeat of the C9orf72 gene and blocks interaction of RNA-binding proteins. J Biol Chem. 2014 Feb 21; 289(8):4653-9. PMID: 24371143; PMCID: PMC3931028.
    16. Axford MM, Wang YH, Nakamori M, Zannis-Hadjopoulos M, Thornton CA, Pearson CE. Detection of slipped-DNAs at the trinucleotide repeats of the myotonic dystrophy type I disease locus in patient tissues. PLoS Genet. 2013; 9(12):e1003866. PMID: 24367268; PMCID: PMC3868534.
    17. Mason AG, Tomé S, Simard JP, Libby RT, Bammler TK, Beyer RP, Morton AJ, Pearson CE, La Spada AR. Expression levels of DNA replication and repair genes predict regional somatic repeat instability in the brain but are not altered by polyglutamine disease protein expression or age. Hum Mol Genet. 2014 Mar 15; 23(6):1606-18. PMID: 24191263; PMCID: PMC3929096.
    18. Pinto RM, Dragileva E, Kirby A, Lloret A, Lopez E, St Claire J, Panigrahi GB, Hou C, Holloway K, Gillis T, Guide JR, Cohen PE, Li GM, Pearson CE, Daly MJ, Wheeler VC. Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches. PLoS Genet. 2013 Oct; 9(10):e1003930. PMID: 24204323; PMCID: PMC3814320.
    19. Reddy K, Pearson CE. RAN translation: fragile X in the running. Neuron. 2013 May 08; 78(3):405-8. PMID: 23664607.
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    20. Axford MM, Pearson CE. Illuminating CNS and cognitive issues in myotonic dystrophy: Workshop report. Neuromuscul Disord. 2013 Apr; 23(4):370-4. PMID: 23453858.
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    21. Tomé S, Manley K, Simard JP, Clark GW, Slean MM, Swami M, Shelbourne PF, Tillier ER, Monckton DG, Messer A, Pearson CE. MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington's disease mice. PLoS Genet. 2013; 9(2):e1003280. PMID: 23468640; PMCID: PMC3585117.
    22. Reddy K, Zamiri B, Stanley SY, Macgregor RB, Pearson CE. The disease-associated r(GGGGCC)n repeat from the C9orf72 gene forms tract length-dependent uni- and multimolecular RNA G-quadruplex structures. J Biol Chem. 2013 Apr 05; 288(14):9860-6. PMID: 23423380; PMCID: PMC3617286.
    23. Slean MM, Reddy K, Wu B, Nichol Edamura K, Kekis M, Nelissen FH, Aspers RL, Tessari M, Schärer OD, Wijmenga SS, Pearson CE. Interconverting conformations of slipped-DNA junctions formed by trinucleotide repeats affect repair outcome. Biochemistry. 2013 Feb 05; 52(5):773-85. PMID: 23339280; PMCID: PMC3566650.
    24. Tomé S, Simard JP, Slean MM, Holt I, Morris GE, Wojciechowicz K, te Riele H, Pearson CE. Tissue-specific mismatch repair protein expression: MSH3 is higher than MSH6 in multiple mouse tissues. DNA Repair (Amst). 2013 Jan 01; 12(1):46-52. PMID: 23228367.
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    25. Hick A, Wattenhofer-Donzé M, Chintawar S, Tropel P, Simard JP, Vaucamps N, Gall D, Lambot L, André C, Reutenauer L, Rai M, Teletin M, Messaddeq N, Schiffmann SN, Viville S, Pearson CE, Pandolfo M, Puccio H. Neurons and cardiomyocytes derived from induced pluripotent stem cells as a model for mitochondrial defects in Friedreich's ataxia. Dis Model Mech. 2013 May; 6(3):608-21. PMID: 23136396; PMCID: PMC3634645.
    26. Panigrahi GB, Slean MM, Simard JP, Pearson CE. Human mismatch repair protein hMutLa is required to repair short slipped-DNAs of trinucleotide repeats. J Biol Chem. 2012 Dec 07; 287(50):41844-50. PMID: 23086927; PMCID: PMC3516732.
    27. Goula AV, Pearson CE, Della Maria J, Trottier Y, Tomkinson AE, Wilson DM, Merienne K. The nucleotide sequence, DNA damage location, and protein stoichiometry influence the base excision repair outcome at CAG/CTG repeats. Biochemistry. 2012 May 08; 51(18):3919-32. PMID: 22497302.
      View in: PubMed
    28. Rudnicki DD, Margolis RL, Pearson CE, Krzyzosiak WJ. Diced triplets expose neurons to RISC. PLoS Genet. 2012; 8(2):e1002545. PMID: 22383898; PMCID: PMC3285583.
    29. Pearson CE. [Repeat-associated diseases, mutagenesis, pathogenesis, and therapeutic avenues]. Rinsho Shinkeigaku. 2012; 52(11):1023. PMID: 23196503.
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    30. Eyries M, Coulet F, Girerd B, Montani D, Humbert M, Lacombe P, Chinet T, Gouya L, Roume J, Axford MM, Pearson CE, Soubrier F. ACVRL1 germinal mosaic with two mutant alleles in hereditary hemorrhagic telangiectasia associated with pulmonary arterial hypertension. Clin Genet. 2012 Aug; 82(2):173-9. PMID: 21651515.
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    31. Axford MM, López-Castel A, Nakamori M, Thornton CA, Pearson CE. Replacement of the myotonic dystrophy type 1 CTG repeat with 'non-CTG repeat' insertions in specific tissues. J Med Genet. 2011 Jul; 48(7):438-43. PMID: 21622935; PMCID: PMC3379714.
    32. López Castel A, Nakamori M, Thornton CA, Pearson CE. Identification of restriction endonucleases sensitive to 5-cytosine methylation at non-CpG sites, including expanded (CAG)n/(CTG)n repeats. Epigenetics. 2011 Apr; 6(4):416-20. PMID: 21364324; PMCID: PMC3230536.
    33. Pearson CE. Repeat associated non-ATG translation initiation: one DNA, two transcripts, seven reading frames, potentially nine toxic entities! PLoS Genet. 2011 Mar; 7(3):e1002018. PMID: 21423665; PMCID: PMC3053344.
    34. Tomé S, Panigrahi GB, López Castel A, Foiry L, Melton DW, Gourdon G, Pearson CE. Maternal germline-specific effect of DNA ligase I on CTG/CAG instability. Hum Mol Genet. 2011 Jun 01; 20(11):2131-43. PMID: 21378394.
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    35. Nakamori M, Pearson CE, Thornton CA. Bidirectional transcription stimulates expansion and contraction of expanded (CTG)*(CAG) repeats. Hum Mol Genet. 2011 Feb 01; 20(3):580-8. PMID: 21088112; PMCID: PMC3016912.
    36. Reddy K, Tam M, Bowater RP, Barber M, Tomlinson M, Nichol Edamura K, Wang YH, Pearson CE. Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats. Nucleic Acids Res. 2011 Mar; 39(5):1749-62. PMID: 21051337; PMCID: PMC3061079.
    37. López Castel A, Nakamori M, Tomé S, Chitayat D, Gourdon G, Thornton CA, Pearson CE. Expanded CTG repeat demarcates a boundary for abnormal CpG methylation in myotonic dystrophy patient tissues. Hum Mol Genet. 2011 Jan 01; 20(1):1-15. PMID: 21044947; PMCID: PMC3000673.
    38. Pearson CE. FSHD: a repeat contraction disease finally ready to expand (our understanding of its pathogenesis). PLoS Genet. 2010 Oct 28; 6(10):e1001180. PMID: 21060814; PMCID: PMC2965764.
    39. Seriola A, Spits C, Simard JP, Hilven P, Haentjens P, Pearson CE, Sermon K. Huntington's and myotonic dystrophy hESCs: down-regulated trinucleotide repeat instability and mismatch repair machinery expression upon differentiation. Hum Mol Genet. 2011 Jan 01; 20(1):176-85. PMID: 20935170.
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    40. Cleary JD, Tomé S, López Castel A, Panigrahi GB, Foiry L, Hagerman KA, Sroka H, Chitayat D, Gourdon G, Pearson CE. Tissue- and age-specific DNA replication patterns at the CTG/CAG-expanded human myotonic dystrophy type 1 locus. Nat Struct Mol Biol. 2010 Sep; 17(9):1079-87. PMID: 20711191.
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    41. Panigrahi GB, Slean MM, Simard JP, Gileadi O, Pearson CE. Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12593-8. PMID: 20571119; PMCID: PMC2906547.
    42. López Castel A, Cleary JD, Pearson CE. Repeat instability as the basis for human diseases and as a potential target for therapy. Nat Rev Mol Cell Biol. 2010 Mar; 11(3):165-70. PMID: 20177394.
      View in: PubMed
    43. Warby SC, Visscher H, Butland S, Pearson CE, Hayden MR. Response to Falush: a role for cis-element polymorphisms in HD. Am J Hum Genet. 2009 Dec; 85(6):942-5. PMID: 20004773; PMCID: PMC2790565.
    44. López Castel A, Tomkinson AE, Pearson CE. CTG/CAG repeat instability is modulated by the levels of human DNA ligase I and its interaction with proliferating cell nuclear antigen: a distinction between replication and slipped-DNA repair. J Biol Chem. 2009 Sep 25; 284(39):26631-45. PMID: 19628465; PMCID: PMC2785351.
    45. Tomé S, Holt I, Edelmann W, Morris GE, Munnich A, Pearson CE, Gourdon G. MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice. PLoS Genet. 2009 May; 5(5):e1000482. PMID: 19436705; PMCID: PMC2674216.
    46. Hagerman KA, Ruan H, Edamura KN, Matsuura T, Pearson CE, Wang YH. The ATTCT repeats of spinocerebellar ataxia type 10 display strong nucleosome assembly which is enhanced by repeat interruptions. Gene. 2009 Apr 01; 434(1-2):29-34. PMID: 19171184.
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    47. Libby RT, Hagerman KA, Pineda VV, Lau R, Cho DH, Baccam SL, Axford MM, Cleary JD, Moore JM, Sopher BL, Tapscott SJ, Filippova GN, Pearson CE, La Spada AR. CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination. PLoS Genet. 2008 Nov; 4(11):e1000257. PMID: 19008940; PMCID: PMC2573955.
    48. Slean MM, Panigrahi GB, Ranum LP, Pearson CE. Mutagenic roles of DNA "repair" proteins in antibody diversity and disease-associated trinucleotide repeat instability. DNA Repair (Amst). 2008 Jul 01; 7(7):1135-54. PMID: 18485833.
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    49. Christodoulou J, Craig HJ, Walker DC, Weaving LS, Pearson CE, McInnes RR. Deletion hotspot in the argininosuccinate lyase gene: association with topoisomerase II and DNA polymerase alpha sites. Hum Mutat. 2006 Nov; 27(11):1065-71. PMID: 16941645.
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    50. Matsuura T, Fang P, Pearson CE, Jayakar P, Ashizawa T, Roa BB, Nelson DL. Interruptions in the expanded ATTCT repeat of spinocerebellar ataxia type 10: repeat purity as a disease modifier? Am J Hum Genet. 2006 Jan; 78(1):125-9. PMID: 16385455; PMCID: PMC1380209.
    51. Nichol Edamura K, Pearson CE. DNA methylation and replication: implications for the "deletion hotspot" region of FMR1. Hum Genet. 2005 Nov; 118(2):301-4. PMID: 16133176.
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    52. Pearson CE, Nichol Edamura K, Cleary JD. Repeat instability: mechanisms of dynamic mutations. Nat Rev Genet. 2005 Oct; 6(10):729-42. PMID: 16205713.
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    53. Panigrahi GB, Lau R, Montgomery SE, Leonard MR, Pearson CE. Slipped (CTG)*(CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair. Nat Struct Mol Biol. 2005 Aug; 12(8):654-62. PMID: 16025129.
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    54. Cleary JD, Pearson CE. Replication fork dynamics and dynamic mutations: the fork-shift model of repeat instability. Trends Genet. 2005 May; 21(5):272-80. PMID: 15851063.
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    55. Nichol Edamura K, Leonard MR, Pearson CE. Role of replication and CpG methylation in fragile X syndrome CGG deletions in primate cells. Am J Hum Genet. 2005 Feb; 76(2):302-11. PMID: 15625623; PMCID: PMC1196375.
    56. Mulvihill DJ, Nichol Edamura K, Hagerman KA, Pearson CE, Wang YH. Effect of CAT or AGG interruptions and CpG methylation on nucleosome assembly upon trinucleotide repeats on spinocerebellar ataxia, type 1 and fragile X syndrome. J Biol Chem. 2005 Feb 11; 280(6):4498-503. PMID: 15574425.
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    57. Pearson CE. Slipping while sleeping? Trinucleotide repeat expansions in germ cells. Trends Mol Med. 2003 Nov; 9(11):490-5. PMID: 14604827.
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    58. Yang Z, Lau R, Marcadier JL, Chitayat D, Pearson CE. Replication inhibitors modulate instability of an expanded trinucleotide repeat at the myotonic dystrophy type 1 disease locus in human cells. Am J Hum Genet. 2003 Nov; 73(5):1092-105. PMID: 14574643; PMCID: PMC1180489.
    59. Tam M, Erin Montgomery S, Kekis M, Stollar BD, Price GB, Pearson CE. Slipped (CTG).(CAG) repeats of the myotonic dystrophy locus: surface probing with anti-DNA antibodies. J Mol Biol. 2003 Sep 19; 332(3):585-600. PMID: 12963369.
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    60. Jin P, Zarnescu DC, Zhang F, Pearson CE, Lucchesi JC, Moses K, Warren ST. RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila. Neuron. 2003 Aug 28; 39(5):739-47. PMID: 12948442.
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    61. Marcadier JL, Pearson CE. Fidelity of primate cell repair of a double-strand break within a (CTG).(CAG) tract. Effect of slipped DNA structures. J Biol Chem. 2003 Sep 05; 278(36):33848-56. PMID: 12807901.
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    62. Libby RT, Monckton DG, Fu YH, Martinez RA, McAbney JP, Lau R, Einum DD, Nichol K, Ware CB, Ptacek LJ, Pearson CE, La Spada AR. Genomic context drives SCA7 CAG repeat instability, while expressed SCA7 cDNAs are intergenerationally and somatically stable in transgenic mice. Hum Mol Genet. 2003 Jan 01; 12(1):41-50. PMID: 12490531.
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    63. Cleary JD, Pearson CE. The contribution of cis-elements to disease-associated repeat instability: clinical and experimental evidence. Cytogenet Genome Res. 2003; 100(1-4):25-55. PMID: 14526163.
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    64. Pearson CE, Tam M, Wang YH, Montgomery SE, Dar AC, Cleary JD, Nichol K. Slipped-strand DNAs formed by long (CAG)*(CTG) repeats: slipped-out repeats and slip-out junctions. Nucleic Acids Res. 2002 Oct 15; 30(20):4534-47. PMID: 12384601; PMCID: PMC137136.
    65. Nichol K, Pearson CE. CpG methylation modifies the genetic stability of cloned repeat sequences. Genome Res. 2002 Aug; 12(8):1246-56. PMID: 12176932; PMCID: PMC186631.
    66. Cleary JD, Nichol K, Wang YH, Pearson CE. Evidence of cis-acting factors in replication-mediated trinucleotide repeat instability in primate cells. Nat Genet. 2002 May; 31(1):37-46. PMID: 11967533.
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    67. Panigrahi GB, Cleary JD, Pearson CE. In vitro (CTG)*(CAG) expansions and deletions by human cell extracts. J Biol Chem. 2002 Apr 19; 277(16):13926-34. PMID: 11832482.
      View in: PubMed
    68. Sinden RR, Potaman VN, Oussatcheva EA, Pearson CE, Lyubchenko YL, Shlyakhtenko LS. Triplet repeat DNA structures and human genetic disease: dynamic mutations from dynamic DNA. J Biosci. 2002 Feb; 27(1 Suppl 1):53-65. PMID: 11927777.
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    69. Novac O, Alvarez D, Pearson CE, Price GB, Zannis-Hadjopoulos M. The human cruciform-binding protein, CBP, is involved in DNA replication and associates in vivo with mammalian replication origins. J Biol Chem. 2002 Mar 29; 277(13):11174-83. PMID: 11805087.
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    70. LeProust EM, Pearson CE, Sinden RR, Gao X, Pearso CE. Unexpected formation of parallel duplex in GAA and TTC trinucleotide repeats of Friedreich's ataxia. J Mol Biol. 2000 Oct 06; 302(5):1063-80. PMID: 11183775.
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    71. Westwood NB, Gruszka-Westwood AM, Pearson CE, Delord CF, Green AR, Huntly BJ, Lakhani A, McMullin MF, Pearson TC. The incidences of trisomy 8, trisomy 9 and D20S108 deletion in polycythaemia vera: an analysis of blood granulocytes using interphase fluorescence in situ hybridization. Br J Haematol. 2000 Sep; 110(4):839-46. PMID: 11054066.
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    72. Pearson CE, Sinden RR. Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNA. Curr Opin Struct Biol. 1998 Jun; 8(3):321-30. PMID: 9666328.
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    73. Pearson CE, Eichler EE, Lorenzetti D, Kramer SF, Zoghbi HY, Nelson DL, Sinden RR. Interruptions in the triplet repeats of SCA1 and FRAXA reduce the propensity and complexity of slipped strand DNA (S-DNA) formation. Biochemistry. 1998 Feb 24; 37(8):2701-8. PMID: 9485421.
      View in: PubMed
    74. Pearson CE, Wang YH, Griffith JD, Sinden RR. Structural analysis of slipped-strand DNA (S-DNA) formed in (CTG)n. (CAG)n repeats from the myotonic dystrophy locus. Nucleic Acids Res. 1998 Feb 01; 26(3):816-23. PMID: 9443975; PMCID: PMC147324.
    75. Pearson CE, Ewel A, Acharya S, Fishel RA, Sinden RR. Human MSH2 binds to trinucleotide repeat DNA structures associated with neurodegenerative diseases. Hum Mol Genet. 1997 Jul; 6(7):1117-23. PMID: 9215683.
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    76. Pearson CE, Zorbas H, Price GB, Zannis-Hadjopoulos M. Inverted repeats, stem-loops, and cruciforms: significance for initiation of DNA replication. J Cell Biochem. 1996 Oct; 63(1):1-22. PMID: 8891900.
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    77. Kramer PR, Pearson CE, Sinden RR. Stability of triplet repeats of myotonic dystrophy and fragile X loci in human mutator mismatch repair cell lines. Hum Genet. 1996 Aug; 98(2):151-7. PMID: 8698331.
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    78. Pearson CE, Sinden RR. Alternative structures in duplex DNA formed within the trinucleotide repeats of the myotonic dystrophy and fragile X loci. Biochemistry. 1996 Apr 16; 35(15):5041-53. PMID: 8664297.
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    79. Ruiz MT, Pearson CE, Nielsen T, Price GB, Zannis-Hadjopoulos M. Cofractionation of HeLa cell replication proteins with ors-binding activity. J Cell Biochem. 1995 Jun; 58(2):221-36. PMID: 7673329.
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    80. Pearson CE, Zannis-Hadjopoulos M, Price GB, Zorbas H. A novel type of interaction between cruciform DNA and a cruciform binding protein from HeLa cells. EMBO J. 1995 Apr 03; 14(7):1571-80. PMID: 7729431; PMCID: PMC398244.
    81. Todd A, Landry S, Pearson CE, Khoury V, Zannis-Hadjopoulos M. Deletion analysis of minimal sequence requirements for autonomous replication of ors8, a monkey early-replicating DNA sequence. J Cell Biochem. 1995 Feb; 57(2):280-9. PMID: 7759565.
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    82. Pearson CE, Ruiz MT, Price GB, Zannis-Hadjopoulos M. Cruciform DNA binding protein in HeLa cell extracts. Biochemistry. 1994 Nov 29; 33(47):14185-96. PMID: 7947830.
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    83. Pearson CE, Shihab-el-Deen A, Price GB, Zannis-Hadjopoulos M. Electron microscopic analysis of in vitro replication products of ors 8, a mammalian origin enriched sequence. Somat Cell Mol Genet. 1994 May; 20(3):147-52. PMID: 7940016.
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    84. Pearson CE, Frappier L, Zannis-Hadjopoulos M. Plasmids bearing mammalian DNA-replication origin-enriched (ors) fragments initiate semiconservative replication in a cell-free system. Biochim Biophys Acta. 1991 Oct 08; 1090(2):156-66. PMID: 1657184.
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