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Sylvain Baruchel

TitlePhysician Clinical Advisor
InstitutionThe Hospital for Sick Children
DepartmentHaematology/Oncology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Poggesi I, Valenzuela B, Ouellet D, Gonzalez M, Hillewaert V, Baruchel S, Fox E, Perez-Ruixo JJ. Population pharmacokinetics of trabectedin in adolescent patients with cancer. Cancer Chemother Pharmacol. 2019 10; 84(4):707-717. PMID: 31286189.
      View in: PubMed
    2. Langenberg-Ververgaert KPS, Renzi S, Chung CT, Shago M, Lo W, Davidson S, Villani A, Baruchel S, Irwin MS, Morgenstern DA. MYCN Amplified Relapse Following Resolution of MYCN Nonamplified 4S Neuroblastoma With Placental Involvement: A Case Report and Review of the Literature. J Pediatr Hematol Oncol. 2019 Jul; 41(5):388-391. PMID: 31094905.
      View in: PubMed
    3. Alexander N, Marrano P, Thorner P, Naranjo A, Van Ryn C, Martinez D, Batra V, Zhang L, Irwin MS, Baruchel S. Prevalence and Clinical Correlations of Somatostatin Receptor-2 (SSTR2) Expression in Neuroblastoma. J Pediatr Hematol Oncol. 2019 04; 41(3):222-227. PMID: 30334904.
      View in: PubMed
    4. Johnston DL, Zupanec S, Nicksy D, Morgenstern D, Narendran A, Deyell RJ, Samson Y, Wu B, Baruchel S. Phase I dose-finding study for melatonin in pediatric oncology patients with relapsed solid tumors. Pediatr Blood Cancer. 2019 06; 66(6):e27676. PMID: 30786157.
      View in: PubMed
    5. Deyell RJ, Wu B, Rassekh SR, Tu D, Samson Y, Fleming A, Bouffet E, Sun X, Powers J, Seymour L, Baruchel S, Morgenstern DA. Phase I study of vinblastine and temsirolimus in pediatric patients with recurrent or refractory solid tumors: Canadian Cancer Trials Group Study IND.218. Pediatr Blood Cancer. 2019 03; 66(3):e27540. PMID: 30393943.
      View in: PubMed
    6. Fahy AS, Kong I, Weitzman S, Dix D, Baruchel S, Gerstle JT. A role for surgery in the treatment of relapsed Hodgkin lymphoma. Pediatr Blood Cancer. 2019 01; 66(1):e27402. PMID: 30294914.
      View in: PubMed
    7. Moreno L, Casanova M, Chisholm JC, Berlanga P, Chastagner PB, Baruchel S, Amoroso L, Gallego Melcón S, Gerber NU, Bisogno G, Fagioli F, Geoerger B, Glade Bender JL, Aerts I, Bergeron C, Hingorani P, Elias I, Simcock M, Ferrara S, Le Bruchec Y, Slepetis R, Chen N, Vassal G. Phase I results of a phase I/II study of weekly nab-paclitaxel in paediatric patients with recurrent/refractory solid tumours: A collaboration with innovative therapies for children with cancer. Eur J Cancer. 2018 09; 100:27-34. PMID: 29936064.
      View in: PubMed
    8. Kumar S, Sun JD, Zhang L, Mokhtari RB, Wu B, Meng F, Liu Q, Bhupathi D, Wang Y, Yeger H, Hart C, Baruchel S. Hypoxia-Targeting Drug Evofosfamide (TH-302) Enhances Sunitinib Activity in Neuroblastoma Xenograft Models. Transl Oncol. 2018 Aug; 11(4):911-919. PMID: 29803017.
      View in: PubMed
    9. Alexander N, Vali R, Ahmadzadehfar H, Shammas A, Baruchel S. Review: The Role of Radiolabeled DOTA-Conjugated Peptides for Imaging and Treatment of Childhood Neuroblastoma. Curr Radiopharm. 2018; 11(1):14-21. PMID: 29243585.
      View in: PubMed
    10. Zhang L, Vines DC, Scollard DA, McKee T, Komal T, Ganguly M, Do T, Wu B, Alexander N, Vali R, Shammas A, Besanger T, Baruchel S. Correlation of Somatostatin Receptor-2 Expression with Gallium-68-DOTA-TATE Uptake in Neuroblastoma Xenograft Models. Contrast Media Mol Imaging. 2017; 2017:9481276. PMID: 29097943.
      View in: PubMed
    11. Leary SES, Park JR, Reid JM, Ralya AT, Baruchel S, Wu B, Roberts TPL, Liu X, Minard CG, Fox E, Weigel B, Blaney S. Pediatric Phase I Trial and Pharmacokinetic Study of Trebananib in Relapsed Solid Tumors, Including Primary Tumors of the Central Nervous System ADVL1115: A Children's Oncology Group Phase I Consortium Report. Clin Cancer Res. 2017 Oct 15; 23(20):6062-6069. PMID: 28751444.
      View in: PubMed
    12. Zhang L, Wu B, Baruchel S. Oral Metronomic Topotecan Sensitizes Crizotinib Antitumor Activity in ALKF1174L Drug-Resistant Neuroblastoma Preclinical Models. Transl Oncol. 2017 Aug; 10(4):604-611. PMID: 28666189.
      View in: PubMed
    13. Bayat Mokhtari R, Baluch N, Ka Hon Tsui M, Kumar S, S Homayouni T, Aitken K, Das B, Baruchel S, Yeger H. Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma. BMC Cancer. 2017 02 24; 17(1):156. PMID: 28235409.
      View in: PubMed
    14. McMahon KR, Rod Rassekh S, Schultz KR, Pinsk M, Blydt-Hansen T, Mammen C, Tsuyuki RT, Devarajan P, Cuvelier GD, Mitchell LG, Baruchel S, Palijan A, Carleton BC, Ross CJ, Zappitelli M. Design and Methods of the Pan-Canadian Applying Biomarkers to Minimize Long-Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Nephrotoxicity Study: A Prospective Observational Cohort Study. Can J Kidney Health Dis. 2017; 4:2054358117690338. PMID: 28270931.
      View in: PubMed
    15. Zhang L, Marrano P, Wu B, Kumar S, Thorner P, Baruchel S. Combined Antitumor Therapy with Metronomic Topotecan and Hypoxia-Activated Prodrug, Evofosfamide, in Neuroblastoma and Rhabdomyosarcoma Preclinical Models. Clin Cancer Res. 2016 06 01; 22(11):2697-708. PMID: 26719428.
      View in: PubMed
    16. Angelini P, Baruchel S, Marrano P, Irwin MS, Thorner PS. The neuroblastoma and ganglion components of nodular ganglioneuroblastoma are genetically similar: evidence against separate clonal origins. Mod Pathol. 2015 Feb; 28(2):166-76. PMID: 25081755.
      View in: PubMed
    17. Bartels U, Wolff J, Gore L, Dunkel I, Gilheeney S, Allen J, Goldman S, Yalon M, Packer RJ, Korones DN, Smith A, Cohen K, Kuttesch J, Strother D, Baruchel S, Gammon J, Kowalski M, Bouffet E. Phase 2 study of safety and efficacy of nimotuzumab in pediatric patients with progressive diffuse intrinsic pontine glioma. Neuro Oncol. 2014 Nov; 16(11):1554-9. PMID: 24847085.
      View in: PubMed
    18. Morgenstern DA, Soh SY, Stavropoulos DJ, Bowdin S, Baruchel S, Malkin D, Meyn MS, Irwin MS. Metachronous neuroblastoma in an infant with germline translocation resulting in partial trisomy 2p: a role for ALK? J Pediatr Hematol Oncol. 2014 Apr; 36(3):e193-6. PMID: 24276038.
      View in: PubMed
    19. Kelley RK, Hwang J, Magbanua MJ, Watt L, Beumer JH, Christner SM, Baruchel S, Wu B, Fong L, Yeh BM, Moore AP, Ko AH, Korn WM, Rajpal S, Park JW, Tempero MA, Venook AP, Bergsland EK. A phase 1 trial of imatinib, bevacizumab, and metronomic cyclophosphamide in advanced colorectal cancer. Br J Cancer. 2013 Oct 01; 109(7):1725-34. PMID: 24022191.
      View in: PubMed
    20. Zhang L, Marrano P, Kumar S, Leadley M, Elias E, Thorner P, Baruchel S. Nab-paclitaxel is an active drug in preclinical model of pediatric solid tumors. Clin Cancer Res. 2013 Nov 01; 19(21):5972-83. PMID: 23989978.
      View in: PubMed
    21. Morgenstern DA, Marzouki M, Bartels U, Irwin MS, Sholler GL, Gammon J, Yankanah R, Wu B, Samson Y, Baruchel S. Phase I study of vinblastine and sirolimus in pediatric patients with recurrent or refractory solid tumors. Pediatr Blood Cancer. 2014 Jan; 61(1):128-33. PMID: 23956145.
      View in: PubMed
    22. Kumar S, Mokhtari RB, Oliveira ID, Islam S, Toledo SR, Yeger H, Baruchel S. Tumor dynamics in response to antiangiogenic therapy with oral metronomic topotecan and pazopanib in neuroblastoma xenografts. Transl Oncol. 2013 Aug; 6(4):493-503. PMID: 23908692.
      View in: PubMed
    23. Zorzi AP, Bernstein M, Samson Y, Wall DA, Desai S, Nicksy D, Wainman N, Eisenhauer E, Baruchel S. A phase I study of histone deacetylase inhibitor, pracinostat (SB939), in pediatric patients with refractory solid tumors: IND203 a trial of the NCIC IND program/C17 pediatric phase I consortium. Pediatr Blood Cancer. 2013 Nov; 60(11):1868-74. PMID: 23893953.
      View in: PubMed
    24. Glade Bender JL, Lee A, Reid JM, Baruchel S, Roberts T, Voss SD, Wu B, Ahern CH, Ingle AM, Harris P, Weigel BJ, Blaney SM. Phase I pharmacokinetic and pharmacodynamic study of pazopanib in children with soft tissue sarcoma and other refractory solid tumors: a children's oncology group phase I consortium report. J Clin Oncol. 2013 Aug 20; 31(24):3034-43. PMID: 23857966.
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    25. Morgenstern DA, Baruchel S, Irwin MS. Current and future strategies for relapsed neuroblastoma: challenges on the road to precision therapy. J Pediatr Hematol Oncol. 2013 Jul; 35(5):337-47. PMID: 23703550.
      View in: PubMed
    26. Ashraf K, Shaikh F, Gibson P, Baruchel S, Irwin MS. Treatment with topotecan plus cyclophosphamide in children with first relapse of neuroblastoma. Pediatr Blood Cancer. 2013 Oct; 60(10):1636-41. PMID: 23650219.
      View in: PubMed
    27. Castelo-Branco P, Choufani S, Mack S, Gallagher D, Zhang C, Lipman T, Zhukova N, Walker EJ, Martin D, Merino D, Wasserman JD, Elizabeth C, Alon N, Zhang L, Hovestadt V, Kool M, Jones DT, Zadeh G, Croul S, Hawkins C, Hitzler J, Wang JC, Baruchel S, Dirks PB, Malkin D, Pfister S, Taylor MD, Weksberg R, Tabori U. Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study. Lancet Oncol. 2013 May; 14(6):534-42. PMID: 23598174.
      View in: PubMed
    28. Steele M, Jones NL, Ng V, Kamath B, Avitzur Y, Chami R, Cutz E, Fecteau A, Baruchel S. Successful liver transplantation in an infant with stage 4S(M) neuroblastoma. Pediatr Blood Cancer. 2013 Mar; 60(3):515-7. PMID: 23152322.
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    29. Felgenhauer JL, Nieder ML, Krailo MD, Bernstein ML, Henry DW, Malkin D, Baruchel S, Chuba PJ, Sailer SL, Brown K, Ranganathan S, Marina N. A pilot study of low-dose anti-angiogenic chemotherapy in combination with standard multiagent chemotherapy for patients with newly diagnosed metastatic Ewing sarcoma family of tumors: A Children's Oncology Group (COG) Phase II study NCT00061893. Pediatr Blood Cancer. 2013 Mar; 60(3):409-14. PMID: 23065953.
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    30. Naithani R, Ngan BY, Roifman C, Crump M, Baruchel S, Abla O. Thymic mucosa-associated lymphoid tissue lymphoma in an adolescent girl. J Pediatr Hematol Oncol. 2012 Oct; 34(7):552-5. PMID: 22469942.
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    31. Kumar S, Mokhtari RB, Yeger H, Baruchel S. Preclinical models for pediatric solid tumor drug discovery: current trends, challenges and the scopes for improvement. Expert Opin Drug Discov. 2012 Nov; 7(11):1093-106. PMID: 22998522.
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    32. Widemann BC, Kim A, Fox E, Baruchel S, Adamson PC, Ingle AM, Glade Bender J, Burke M, Weigel B, Stempak D, Balis FM, Blaney SM. A phase I trial and pharmacokinetic study of sorafenib in children with refractory solid tumors or leukemias: a Children's Oncology Group Phase I Consortium report. Clin Cancer Res. 2012 Nov 01; 18(21):6011-22. PMID: 22962440.
      View in: PubMed
    33. Glade Bender J, Blaney SM, Borinstein S, Reid JM, Baruchel S, Ahern C, Ingle AM, Yamashiro DJ, Chen A, Weigel B, Adamson PC, Park JR. A phase I trial and pharmacokinetic study of aflibercept (VEGF Trap) in children with refractory solid tumors: a children's oncology group phase I consortium report. Clin Cancer Res. 2012 Sep 15; 18(18):5081-9. PMID: 22791883.
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    34. Bouffet E, Jakacki R, Goldman S, Hargrave D, Hawkins C, Shroff M, Hukin J, Bartels U, Foreman N, Kellie S, Hilden J, Etzl M, Wilson B, Stephens D, Tabori U, Baruchel S. Phase II study of weekly vinblastine in recurrent or refractory pediatric low-grade glioma. J Clin Oncol. 2012 Apr 20; 30(12):1358-63. PMID: 22393086.
      View in: PubMed
    35. DuBois SG, Shusterman S, Reid JM, Ingle AM, Ahern CH, Baruchel S, Glade-Bender J, Ivy P, Adamson PC, Blaney SM. Tolerability and pharmacokinetic profile of a sunitinib powder formulation in pediatric patients with refractory solid tumors: a Children's Oncology Group study. Cancer Chemother Pharmacol. 2012 Apr; 69(4):1021-7. PMID: 22179104.
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    36. Angelini P, London WB, Cohn SL, Pearson AD, Matthay KK, Monclair T, Ambros PF, Shimada H, Leuschner I, Peuchmaur M, Irwin MS, Baruchel S. Characteristics and outcome of patients with ganglioneuroblastoma, nodular subtype: a report from the INRG project. Eur J Cancer. 2012 May; 48(8):1185-91. PMID: 22137163.
      View in: PubMed
    37. Baruchel S, Pappo A, Krailo M, Baker KS, Wu B, Villaluna D, Lee-Scott M, Adamson PC, Blaney SM. A phase 2 trial of trabectedin in children with recurrent rhabdomyosarcoma, Ewing sarcoma and non-rhabdomyosarcoma soft tissue sarcomas: a report from the Children's Oncology Group. Eur J Cancer. 2012 Mar; 48(4):579-85. PMID: 22088484.
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    38. Tomlinson D, Bartels U, Gammon J, Hinds PS, Volpe J, Bouffet E, Regier DA, Baruchel S, Greenberg M, Barrera M, Llewellyn-Thomas H, Sung L. Chemotherapy versus supportive care alone in pediatric palliative care for cancer: comparing the preferences of parents and health care professionals. CMAJ. 2011 Nov 22; 183(17):E1252-8. PMID: 22007121.
      View in: PubMed
    39. Pasquier E, Kieran MW, Sterba J, Shaked Y, Baruchel S, Oberlin O, Kivivuori MS, Peyrl A, Diawarra M, Casanova M, Zacharoulis S, Vassal G, Berthold F, Verschuur A, André N. Moving forward with metronomic chemotherapy: meeting report of the 2nd International Workshop on Metronomic and Anti-Angiogenic Chemotherapy in Paediatric Oncology. Transl Oncol. 2011 Aug; 4(4):203-11. PMID: 21804915.
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    40. Kumar S, Mokhtari RB, Sheikh R, Wu B, Zhang L, Xu P, Man S, Oliveira ID, Yeger H, Kerbel RS, Baruchel S. Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor. Clin Cancer Res. 2011 Sep 01; 17(17):5656-67. PMID: 21788355.
      View in: PubMed
    41. Dubois SG, Shusterman S, Ingle AM, Ahern CH, Reid JM, Wu B, Baruchel S, Glade-Bender J, Ivy P, Grier HE, Adamson PC, Blaney SM. Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: a children's oncology group study. Clin Cancer Res. 2011 Aug 01; 17(15):5113-22. PMID: 21690570.
      View in: PubMed
    42. DuBois SG, Stempak D, Wu B, Mokhtari RB, Nayar R, Janeway KA, Goldsby R, Grier HE, Baruchel S. Circulating endothelial cells and circulating endothelial precursor cells in patients with osteosarcoma. Pediatr Blood Cancer. 2012 Feb; 58(2):181-4. PMID: 21319292.
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    43. Bartels U, Baruchel S, Carret AS, Crooks B, Hukin J, Johnston D, Silva M, Strother D, Wilson B, Zelcer S, Eisenstat D, Sung L, Bouffet E. The use and effectiveness of temozolomide in children with central nervous system tumours: a survey from the Canadian Paediatric Brain Tumour Consortium. Curr Oncol. 2011 Jan; 18(1):e19-24. PMID: 21331268.
      View in: PubMed
    44. Gesundheit B, Parkin P, Greenberg M, Baruchel S, Senger C, Kapelushnik J, Smith C, Klement GL. The role of angiogenesis in the transformation of plexiform neurofibroma into malignant peripheral nerve sheath tumors in children with neurofibromatosis type 1. J Pediatr Hematol Oncol. 2010 Oct; 32(7):548-53. PMID: 20686424.
      View in: PubMed
    45. Smith KM, Datti A, Fujitani M, Grinshtein N, Zhang L, Morozova O, Blakely KM, Rotenberg SA, Hansford LM, Miller FD, Yeger H, Irwin MS, Moffat J, Marra MA, Baruchel S, Wrana JL, Kaplan DR. Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens. EMBO Mol Med. 2010 Sep; 2(9):371-84. PMID: 20721990.
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    46. Sharp JR, Bouffet E, Stempak D, Gammon J, Stephens D, Johnston DL, Eisenstat D, Hukin J, Samson Y, Bartels U, Tabori U, Huang A, Baruchel S. A multi-centre Canadian pilot study of metronomic temozolomide combined with radiotherapy for newly diagnosed paediatric brainstem glioma. Eur J Cancer. 2010 Dec; 46(18):3271-9. PMID: 20656474.
      View in: PubMed
    47. Ryan C, Price V, John P, Mahant S, Baruchel S, Brandão L, Blanchette V, Pope E, Weinstein M. Kasabach-Merritt phenomenon: a single centre experience. Eur J Haematol. 2010 Feb 01; 84(2):97-104. PMID: 19889011.
      View in: PubMed
    48. Baruchel S, Sharp JR, Bartels U, Hukin J, Odame I, Portwine C, Strother D, Fryer C, Halton J, Egorin MJ, Reis RM, Martinho O, Stempak D, Hawkins C, Gammon J, Bouffet E. A Canadian paediatric brain tumour consortium (CPBTC) phase II molecularly targeted study of imatinib in recurrent and refractory paediatric central nervous system tumours. Eur J Cancer. 2009 Sep; 45(13):2352-9. PMID: 19505817.
      View in: PubMed
    49. Zhang L, Smith KM, Chong AL, Stempak D, Yeger H, Marrano P, Thorner PS, Irwin MS, Kaplan DR, Baruchel S. In vivo antitumor and antimetastatic activity of sunitinib in preclinical neuroblastoma mouse model. Neoplasia. 2009 May; 11(5):426-35. PMID: 19412427.
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    50. Lau LM, Wolter JK, Lau JT, Cheng LS, Smith KM, Hansford LM, Zhang L, Baruchel S, Robinson F, Irwin MS. Cyclooxygenase inhibitors differentially modulate p73 isoforms in neuroblastoma. Oncogene. 2009 May 14; 28(19):2024-33. PMID: 19363520.
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    51. Das B, Antoon R, Tsuchida R, Lotfi S, Morozova O, Farhat W, Malkin D, Koren G, Yeger H, Baruchel S. Squalene selectively protects mouse bone marrow progenitors against cisplatin and carboplatin-induced cytotoxicity in vivo without protecting tumor growth. Neoplasia. 2008 Oct; 10(10):1105-19. PMID: 18813359.
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    52. Das B, Tsuchida R, Malkin D, Koren G, Baruchel S, Yeger H. Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction. Stem Cells. 2008 Jul; 26(7):1818-30. PMID: 18467664.
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    53. Shah N, Leaker MT, Teshima I, Baruchel S, Abdelhaleem M, Ye CC. Late-appearing Philadelphia chromosome in childhood acute myeloid leukemia. Pediatr Blood Cancer. 2008 May; 50(5):1052-3. PMID: 18213712.
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    54. Tsuchida R, Das B, Yeger H, Koren G, Shibuya M, Thorner PS, Baruchel S, Malkin D. Cisplatin treatment increases survival and expansion of a highly tumorigenic side-population fraction by upregulating VEGF/Flt1 autocrine signaling. Oncogene. 2008 Jun 26; 27(28):3923-34. PMID: 18332870.
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    55. Epstein I, Stevens B, McKeever P, Baruchel S, Jones H. Using puppetry to elicit children's talk for research. Nurs Inq. 2008 Mar; 15(1):49-56. PMID: 18271790.
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    56. Glade Bender JL, Adamson PC, Reid JM, Xu L, Baruchel S, Shaked Y, Kerbel RS, Cooney-Qualter EM, Stempak D, Chen HX, Nelson MD, Krailo MD, Ingle AM, Blaney SM, Kandel JJ, Yamashiro DJ. Phase I trial and pharmacokinetic study of bevacizumab in pediatric patients with refractory solid tumors: a Children's Oncology Group Study. J Clin Oncol. 2008 Jan 20; 26(3):399-405. PMID: 18202416.
      View in: PubMed
    57. Bernhard N, Morris SK, Taylor G, Oudjhane K, Baruchel S. Massive intrathoracic tumor in a relatively asymptomatic boy. Pediatr Ann. 2007 Oct; 36(10):632, 634-5. PMID: 17969530.
      View in: PubMed
    58. Pope E, Krafchik BR, Macarthur C, Stempak D, Stephens D, Weinstein M, Ho N, Baruchel S. Oral versus high-dose pulse corticosteroids for problematic infantile hemangiomas: a randomized, controlled trial. Pediatrics. 2007 Jun; 119(6):e1239-47. PMID: 17485449.
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    59. Seely D, Stempak D, Baruchel S. A strategy for controlling potential interactions between natural health products and chemotherapy: a review in pediatric oncology. J Pediatr Hematol Oncol. 2007 Jan; 29(1):32-47. PMID: 17230065.
      View in: PubMed
    60. Zhang L, Yeger H, Das B, Irwin MS, Baruchel S. Tissue microenvironment modulates CXCR4 expression and tumor metastasis in neuroblastoma. Neoplasia. 2007 Jan; 9(1):36-46. PMID: 17325742.
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    61. Stempak D, Gammon J, Halton J, Moghrabi A, Koren G, Baruchel S. A pilot pharmacokinetic and antiangiogenic biomarker study of celecoxib and low-dose metronomic vinblastine or cyclophosphamide in pediatric recurrent solid tumors. J Pediatr Hematol Oncol. 2006 Nov; 28(11):720-8. PMID: 17114958.
      View in: PubMed
    62. Lau L, Hansford LM, Cheng LS, Hang M, Baruchel S, Kaplan DR, Irwin MS. Cyclooxygenase inhibitors modulate the p53/HDM2 pathway and enhance chemotherapy-induced apoptosis in neuroblastoma. Oncogene. 2007 Mar 22; 26(13):1920-31. PMID: 16983334.
      View in: PubMed
    63. Buckstein R, Kerbel RS, Shaked Y, Nayar R, Foden C, Turner R, Lee CR, Taylor D, Zhang L, Man S, Baruchel S, Stempak D, Bertolini F, Crump M. High-Dose celecoxib and metronomic "low-dose" cyclophosphamide is an effective and safe therapy in patients with relapsed and refractory aggressive histology non-Hodgkin's lymphoma. Clin Cancer Res. 2006 Sep 01; 12(17):5190-8. PMID: 16951238.
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    64. Baruchel S, Diezi M, Hargrave D, Stempak D, Gammon J, Moghrabi A, Coppes MJ, Fernandez CV, Bouffet E. Safety and pharmacokinetics of temozolomide using a dose-escalation, metronomic schedule in recurrent paediatric brain tumours. Eur J Cancer. 2006 Sep; 42(14):2335-42. PMID: 16899365.
      View in: PubMed
    65. Baruchel S, Stempak D. Low-dose metronomic chemotherapy: myth or truth? Onkologie. 2006 Jul; 29(7):305-7. PMID: 16874013.
      View in: PubMed
    66. Stempak D, Seely D, Baruchel S. Metronomic dosing of chemotherapy: applications in pediatric oncology. Cancer Invest. 2006 Jun-Jul; 24(4):432-43. PMID: 16777697.
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    67. Lee A, Frischer J, Serur A, Huang J, Bae JO, Kornfield ZN, Eljuga L, Shawber CJ, Feirt N, Mansukhani M, Stempak D, Baruchel S, Glade Bender J, Kandel JJ, Yamashiro DJ. Inhibition of cyclooxygenase-2 disrupts tumor vascular mural cell recruitment and survival signaling. Cancer Res. 2006 Apr 15; 66(8):4378-84. PMID: 16618763.
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    68. Tomlinson D, Capra M, Gammon J, Volpe J, Barrera M, Hinds PS, Bouffet E, Geenberg ML, Baruchel S, Llewellyn-Thomas HA, Sung L. Parental decision making in pediatric cancer end-of-life care: using focus group methodology as a prephase to seek participant design input. Eur J Oncol Nurs. 2006 Jul; 10(3):198-206. PMID: 16384746.
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    69. Gee MF, Tsuchida R, Eichler-Jonsson C, Das B, Baruchel S, Malkin D. Vascular endothelial growth factor acts in an autocrine manner in rhabdomyosarcoma cell lines and can be inhibited with all-trans-retinoic acid. Oncogene. 2005 Dec 01; 24(54):8025-37. PMID: 16116481.
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    70. Lau L, Baruchel S. Can Canada sustain paediatric phase I trials? A national survey of cancer relapse in children. Can J Clin Pharmacol. 2005; 12(3):e222-8. PMID: 16278494.
      View in: PubMed
    71. Stempak D, Bukaveckas BL, Linder M, Koren G, Baruchel S. Cytochrome P450 2C9 genotype: impact on celecoxib safety and pharmacokinetics in a pediatric patient. Clin Pharmacol Ther. 2005 Sep; 78(3):309-10. PMID: 16153401.
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    72. Barrera M, D'Agostino N, Gammon J, Spencer L, Baruchel S. Health-related quality of life and enrollment in phase 1 trials in children with incurable cancer. Palliat Support Care. 2005 Sep; 3(3):191-6. PMID: 16594458.
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    73. Das B, Yeger H, Tsuchida R, Torkin R, Gee MF, Thorner PS, Shibuya M, Malkin D, Baruchel S. A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxia-inducible factor-1alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma. Cancer Res. 2005 Aug 15; 65(16):7267-75. PMID: 16103078.
      View in: PubMed
    74. Stempak D, Gammon J, Halton J, Champagne M, Koren G, Baruchel S. Modulation of celecoxib pharmacokinetics by food in pediatric patients. Clin Pharmacol Ther. 2005 Mar; 77(3):226-8. PMID: 15735617.
      View in: PubMed
    75. Lau L, Supko JG, Blaney S, Hershon L, Seibel N, Krailo M, Qu W, Malkin D, Jimeno J, Bernstein M, Baruchel S. A phase I and pharmacokinetic study of ecteinascidin-743 (Yondelis) in children with refractory solid tumors. A Children's Oncology Group study. Clin Cancer Res. 2005 Jan 15; 11(2 Pt 1):672-7. PMID: 15701855.
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    76. Cervi D, Klement G, Stempak D, Baruchel S, Koki A, Ben-David Y. Targeting cyclooxygenase-2 reduces overt toxicity toward low-dose vinblastine and extends survival of juvenile mice with Friend disease. Clin Cancer Res. 2005 Jan 15; 11(2 Pt 1):712-9. PMID: 15701860.
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    77. He Y, Das B, Baruchel S, Kumar P, Wiebe L, Reilly RM. Meta-[123I]iodobenzylguanidine is selectively radiotoxic to neuroblastoma cells at concentrations that spare cells of haematopoietic lineage. Nucl Med Commun. 2004 Nov; 25(11):1125-30. PMID: 15577592.
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    78. Stevens B, Kagan S, Yamada J, Epstein I, Beamer M, Bilodeau M, Baruchel S. Adventure therapy for adolescents with cancer. Pediatr Blood Cancer. 2004 Sep; 43(3):278-84. PMID: 15266414.
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    79. Chilton-Macneill S, Ho M, Hawkins C, Gassas A, Zielenska M, Baruchel S. C-kit expression and mutational analysis in medulloblastoma. Pediatr Dev Pathol. 2004 Sep-Oct; 7(5):493-8. PMID: 15547773.
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    80. Lau L, Tai D, Weitzman S, Grant R, Baruchel S, Malkin D. Factors influencing survival in children with recurrent neuroblastoma. J Pediatr Hematol Oncol. 2004 Apr; 26(4):227-32. PMID: 15087949.
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    81. Gesundheit B, Klement G, Senger C, Kerbel R, Kieran M, Baruchel S, Becker L. Differences in vasculature between pilocytic and anaplastic astrocytomas of childhood. Med Pediatr Oncol. 2003 Dec; 41(6):516-26. PMID: 14595708.
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    82. Hargrave D, Bouffet E, Gammon J, Becker L, Rutka J, Baruchel S. Response to low dose temozolomide in radiation induced gliomatosis cerebri. Med Pediatr Oncol. 2003 Dec; 41(6):562-4. PMID: 14595716.
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    83. Das B, Yeger H, Baruchel H, Freedman MH, Koren G, Baruchel S. In vitro cytoprotective activity of squalene on a bone marrow versus neuroblastoma model of cisplatin-induced toxicity. implications in cancer chemotherapy. Eur J Cancer. 2003 Nov; 39(17):2556-65. PMID: 14602142.
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    84. Dallas S, Zhu X, Baruchel S, Schlichter L, Bendayan R. Functional expression of the multidrug resistance protein 1 in microglia. J Pharmacol Exp Ther. 2003 Oct; 307(1):282-90. PMID: 12893836.
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    85. Langevin AM, Weitman SD, Kuhn JG, Weintraub ST, Baruchel S, Furman W, Bernstein M, Blaney S, Vietti T. Phase I trial of rebeccamycin analog (NSC #655649) in children with refractory solid tumors: a pediatric oncology group study. J Pediatr Hematol Oncol. 2003 Jul; 25(7):526-33. PMID: 12847318.
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    86. Knoppert DC, Stempak D, Baruchel S, Koren G. Celecoxib in human milk: a case report. Pharmacotherapy. 2003 Jan; 23(1):97-100. PMID: 12523466.
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    87. Stempak D, Gammon J, Klein J, Koren G, Baruchel S. Single-dose and steady-state pharmacokinetics of celecoxib in children. Clin Pharmacol Ther. 2002 Nov; 72(5):490-7. PMID: 12426512.
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    88. Hargrave DR, Bouffet E, Gammon J, Tariq N, Grant RM, Baruchel S. Phase I study of fotemustine in pediatric patients with refractory brain tumors. Cancer. 2002 Sep 15; 95(6):1294-301. PMID: 12216098.
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    89. Furman WL, Stewart CF, Kirstein M, Kepner JL, Bernstein ML, Kung F, Vietti TJ, Steuber CP, Becton DL, Baruchel S, Pratt C. Protracted intermittent schedule of topotecan in children with refractory acute leukemia: a pediatric oncology group study. J Clin Oncol. 2002 Mar 15; 20(6):1617-24. PMID: 11896112.
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    90. McDermid JM, Lalonde RG, Gray-Donald K, Baruchel S, Kubow S. Associations between dietary antioxidant intake and oxidative stress in HIV-seropositive and HIV-seronegative men and women. J Acquir Immune Defic Syndr. 2002 Feb 01; 29(2):158-64. PMID: 11832685.
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    91. Stempak D, Dallas S, Klein J, Bendayan R, Koren G, Baruchel S. Glutathione stability in whole blood: effects of various deproteinizing acids. Ther Drug Monit. 2001 Oct; 23(5):542-9. PMID: 11591901.
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    92. Fouladi M, Stempak D, Gammon J, Klein J, Grant R, Greenberg ML, Koren G, Baruchel S. Phase I trial of a twice-daily regimen of amifostine with ifosfamide, carboplatin, and etoposide chemotherapy in children with refractory carcinoma. Cancer. 2001 Aug 15; 92(4):914-23. PMID: 11550166.
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    93. Gesundheit B, Cividalli G, Freeman A, Yatziv S, Koren G, Baruchel S. Cyclosporin A in the treatment of refractory immune thrombocytopenia purpura in children. Eur J Haematol. 2001 May; 66(5):347-51. PMID: 11422416.
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    94. Klement G, Baruchel S, Rak J, Man S, Clark K, Hicklin DJ, Bohlen P, Kerbel RS. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J Clin Invest. 2000 Apr; 105(8):R15-24. PMID: 10772661.
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    95. Bernstein ML, Baruchel S, Devine S, Markoglou N, Wainer IW, Williams M, Blaney S, Moghrabi A, Winick N, Vietti T. Phase I and pharmacokinetic study of CI-980 in recurrent pediatric solid tumor cases: a Pediatric Oncology Group study. J Pediatr Hematol Oncol. 1999 Nov-Dec; 21(6):494-500. PMID: 10598660.
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    96. Loebstein R, Atanackovic G, Bishai R, Wolpin J, Khattak S, Hashemi G, Gobrial M, Baruchel S, Ito S, Koren G. Risk factors for long-term outcome of ifosfamide-induced nephrotoxicity in children. J Clin Pharmacol. 1999 May; 39(5):454-61. PMID: 10234592.
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    97. Fouladi M, Baruchel S, Chan H, Grant R, Malkin D, Weitzman S, Greenberg ML. Use of adjuvant ICE chemotherapy in the treatment of anaplastic ependymomas. Childs Nerv Syst. 1998 Oct; 14(10):590-5. PMID: 9840385.
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    98. Fouladi M, Grant R, Baruchel S, Chan H, Malkin D, Weitzman S, Greenberg ML. Comparison of survival outcomes in patients with intracranial germinomas treated with radiation alone versus reduced-dose radiation and chemotherapy. Childs Nerv Syst. 1998 Oct; 14(10):596-601. PMID: 9840386.
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    99. Carcao MD, Taylor GP, Greenberg ML, Bernstein ML, Champagne M, Hershon L, Baruchel S. Renal-cell carcinoma in children: a different disorder from its adult counterpart? Med Pediatr Oncol. 1998 Sep; 31(3):153-8. PMID: 9722897.
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    100. Rahman N, Arbour L, Tonin P, Baruchel S, Pritchard-Jones K, Narod SA, Stratton MR. The familial Wilms' tumour susceptibility gene, FWT1, may not be a tumour suppressor gene. Oncogene. 1997 Jun 26; 14(25):3099-102. PMID: 9223674.
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    101. Toledano BJ, Bastien Y, Noya F, Baruchel S, Mazer B. Platelet-activating factor abrogates apoptosis induced by cross-linking of the surface IgM receptor in a human B lymphoblastoid cell line. J Immunol. 1997 Apr 15; 158(8):3705-15. PMID: 9103434.
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    102. Rahman N, Arbour L, Tonin P, Renshaw J, Pelletier J, Baruchel S, Pritchard-Jones K, Stratton MR, Narod SA. Evidence for a familial Wilms' tumour gene (FWT1) on chromosome 17q12-q21. Nat Genet. 1996 Aug; 13(4):461-3. PMID: 8696342.
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    103. Baruchel S, Viau G. In vitro selective modulation of cellular glutathione by a humanized native milk protein isolate in normal cells and rat mammary carcinoma model. Anticancer Res. 1996 May-Jun; 16(3A):1095-9. PMID: 8702219.
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    104. Vernet O, Montes JL, O'Gorman AM, Baruchel S, Farmer JP. Encephaloduroarterio-synangiosis in a child with sickle cell anemia and moyamoya disease. Pediatr Neurol. 1996 Apr; 14(3):226-30. PMID: 8736407.
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    105. Wang T, Chen X, Schecter RL, Baruchel S, Alaoui-Jamali M, Melnychuk D, Batist G. Modulation of glutathione by a cysteine pro-drug enhances in vivo tumor response. J Pharmacol Exp Ther. 1996 Mar; 276(3):1169-73. PMID: 8786549.
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    106. Kennedy RS, Konok GP, Bounous G, Baruchel S, Lee TD. The use of a whey protein concentrate in the treatment of patients with metastatic carcinoma: a phase I-II clinical study. Anticancer Res. 1995 Nov-Dec; 15(6B):2643-9. PMID: 8669840.
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    107. Baruchel S, Wang T, Farah R, Jamali M, Batist G. In vivo selective modulation of tissue glutathione in a rat mammary carcinoma model. Biochem Pharmacol. 1995 Oct 26; 50(9):1505-8. PMID: 7503802.
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    108. Baruchel S, Bernstein M, Whitehead VM, Devine S, Bell B, Dubowy R, Grier H, Kretschmar C, Langevin AM, Vietti T. A phase I study of acivicin in refractory pediatric solid tumors. A Pediatric Oncology Group study. Invest New Drugs. 1995; 13(3):211-6. PMID: 8729948.
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    109. Brossard J, Abish S, Bernstein ML, Baruchel S, Kovacs L, Pollack R. Maternal malignancy involving the products of conception: a report of malignant melanoma and medulloblastoma. Am J Pediatr Hematol Oncol. 1994 Nov; 16(4):380-3. PMID: 7978062.
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    110. Costagliola DG, de Montalembert M, Lefrère JJ, Briand C, Rebulla P, Baruchel S, Dessi C, Fondu P, Karagiorga M, Perrimond H, et al. Dose of desferrioxamine and evolution of HIV-1 infection in thalassaemic patients. Br J Haematol. 1994 Aug; 87(4):849-52. PMID: 7986727.
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    111. Bounous G, Baruchel S, Falutz J, Gold P. Whey proteins as a food supplement in HIV-seropositive individuals. Clin Invest Med. 1993 Jun; 16(3):204-9. PMID: 8365048.
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    112. Baruchel S, Rees J, Bernstein ML, Goodyer P. Relief of sickle cell priapism by hydralazine. Report of a case. Am J Pediatr Hematol Oncol. 1993 Feb; 15(1):115-6. PMID: 8447552.
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    113. Baruchel S, Delifer JC, Sigalet D, Hong A, Oudjhane K, Chen MF. Pseudomembranous colitis in sickle cell disease responding to exchange transfusion. J Pediatr. 1992 Dec; 121(6):915-7. PMID: 1447655.
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    114. Haddad A, Azouz EM, al-Jedher S, Baruchel S, Bernstein ML, Cotton RT, Tewfik TL. Metastatic neuroblastoma presenting as a mandibular mass. Can Assoc Radiol J. 1992 Dec; 43(6):436-40. PMID: 1450973.
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    115. Baruchel S, Wainberg MA. The role of oxidative stress in disease progression in individuals infected by the human immunodeficiency virus. J Leukoc Biol. 1992 Jul; 52(1):111-4. PMID: 1640166.
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    116. Witkowska HE, Lubin BH, Beuzard Y, Baruchel S, Esseltine DW, Vichinsky EP, Kleman KM, Bardakdjian-Michau J, Pinkoski L, Cahn S, et al. Sickle cell disease in a patient with sickle cell trait and compound heterozygosity for hemoglobin S and hemoglobin Quebec-Chori. N Engl J Med. 1991 Oct 17; 325(16):1150-4. PMID: 1891024.
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    117. Baruchel S, Gao Q, Wainberg MA. Desferrioxamine and HIV. Lancet. 1991 Jun 01; 337(8753):1356. PMID: 1674340.
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    118. Lamour C, Baruchel S, Bertrand Y, Bonnet M, Montagne JP, Vuthien H, Balquet P. [Mucormycosis and diabetes in acute leukemia]. Arch Fr Pediatr. 1988 Apr; 45(4):267-9. PMID: 3408308.
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    119. Bégué P, Quinet B, Gruner M, Cabrol S, Baruchel S. [Pathology of the bile ducts in children with homozygous sickle-cell anemia. Apropos of 5 recent cases]. Ann Med Interne (Paris). 1986; 137(2):115-7. PMID: 3717816.
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    120. Cabrol S, Desjardin F, Baruchel S, Bégué P, Cordier MD, Lasfargues G. [Hydrocholecystis, unrecognized cause of painful abdominal crises in patients with sickle cell anemia]. Arch Fr Pediatr. 1985 Dec; 42(10):859-61. PMID: 3914241.
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    121. Bonnet-Gajdos M, Vasmant D, Baruchel S, Mamou JF, Boue J, Lasfargues G. [Prenatal diagnosis of Fanconi's anemia]. Presse Med. 1985 Sep 14; 14(30):1612. PMID: 2931708.
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