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Mohamed Abdelhaleem

TitleDiv Head Haematopathology
InstitutionThe Hospital for Sick Children
DepartmentPaediatric Laboratory Medicine (PLM)
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhong Y, Beimnet K, Alli Z, Arnoldo A, Kowalski PE, Somers GR, Hawkins C, Abdelhaleem M. Multiplexed Digital Detection of B-cell Acute Lymphoblastic Leukemia Fusion Transcripts Using the NanoString nCounter System. J Mol Diagn. 2019 Nov 13. PMID: 31733350.
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    2. Alkendi J, Renzi S, Manson D, Abdelhaleem M, Naqvi A, Punnett A. Hodgkin Lymphoma in an Adolescent With Isolated Bone Marrow and Bone Involvement: A Case Report and a Review of the Literature. J Pediatr Hematol Oncol. 2019 Aug 14. PMID: 31415282.
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    3. Lam G, Punnett A, Stephens D, Sung L, Abdelhaleem M, Hitzler J. Value of flow cytometric analysis of peripheral blood samples in children diagnosed with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2018 Jan; 65(1). PMID: 28766841.
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    4. Waespe N, Van Den Akker M, Klaassen RJ, Lieberman L, Irwin MS, Ali SS, Abdelhaleem M, Zlateska B, Liebman M, Cada M, Schechter T, Dror Y. Response to treatment with azacitidine in children with advanced myelodysplastic syndrome prior to hematopoietic stem cell transplantation. Haematologica. 2016 12; 101(12):1508-1515. PMID: 27540140.
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    5. Shago M, Abla O, Hitzler J, Weitzman S, Abdelhaleem M. Frequency and outcome of pediatric acute lymphoblastic leukemia with ZNF384 gene rearrangements including a novel translocation resulting in an ARID1B/ZNF384 gene fusion. Pediatr Blood Cancer. 2016 11; 63(11):1915-21. PMID: 27392123.
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    6. Lam GK, Abdelhaleem M, Somers GR, Roifman C, Read S, Abla O. Primary Effusion Lymphoma (PEL)-Like Lymphoma in a Child With Congenital Immunodeficiency. Pediatr Blood Cancer. 2016 09; 63(9):1674-6. PMID: 27186682.
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    7. Grant RC, Shaikh F, Abdelhaleem M, Alexander SW, Cada M. Risk factors for inadequate bone marrow biopsies in children. Am J Hematol. 2015 Sep; 90(9):E187-9. PMID: 26043864.
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    8. Adeli K, Raizman JE, Chen Y, Higgins V, Nieuwesteeg M, Abdelhaleem M, Wong SL, Blais D. Complex biological profile of hematologic markers across pediatric, adult, and geriatric ages: establishment of robust pediatric and adult reference intervals on the basis of the Canadian Health Measures Survey. Clin Chem. 2015 Aug; 61(8):1075-86. PMID: 26044509.
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    9. Abla O, Stimec J, Abdelhaleem M, Howard A. Paediatric acute lymphoblastic leukaemia mimicking Langerhans cell histiocytosis of bone. Br J Haematol. 2015 Mar; 168(6):770. PMID: 25521432.
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    10. van den Akker M, Silverman E, Abdelhaleem M, Kirby-Allen M. Aplastic anemia associated with systemic lupus erythematosus in children - case report and review of the literature. Clin Case Rep. 2014 Dec; 2(6):319-22. PMID: 25548637.
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    11. Evans AB, Kulik D, Banerji A, Boggild A, Kain KC, Abdelhaleem M, Morris SK. Imported pediatric malaria at the Hospital for Sick Children, Toronto, Canada: a 16 year review. BMC Pediatr. 2014 Oct 04; 14:251. PMID: 25281037.
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    12. Schechter T, Gassas A, Chen H, Pollard J, Meshinchi S, Zaidman I, Hitzler J, Abdelhaleem M, Ho R, Domm J, Woolfrey A, Frangoul H. The outcome of allogeneic hematopoietic cell transplantation for children with FMS-like tyrosine kinase 3 internal tandem duplication-positive acute myelogenous leukemia. Biol Blood Marrow Transplant. 2015 Jan; 21(1):172-5. PMID: 25139215.
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    13. Pace-Asciak CR, Li X, Reynaud D, Qiao N, Demin P, Abdelhaleem M. Alterations in eicosanoid levels during U937 bcl-xL tumour growth suppression and recovery in NU/NU mice in vivo-Involvement of phospholipase A2. Prostaglandins Other Lipid Mediat. 2013 Dec; 107:43-7. PMID: 23548786.
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    14. Gerard LM, Xing K, Sherifi I, Granton J, Barth D, Abdelhaleem M, Bergeron C, Weitzman S, Cserti-Gazdewich C. Adult hemophagocytic lymphohistiocytosis with severe pulmonary hypertension and a novel perforin gene mutation. Int J Hematol. 2012 Apr; 95(4):445-50. PMID: 22359105.
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    15. Shahein AR, Gonzalez S, Carcao M, Abdelhaleem M, Hellmann J, McNamara PJ. A case of severe eosinophilia in a preterm infant. Pediatrics. 2011 Mar; 127(3):e767-71. PMID: 21357337.
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    16. Macartney CA, Weitzman S, Wood SM, Bansal D, Steele M, Meeths M, Abdelhaleem M, Bryceson YT. Unusual functional manifestations of a novel STX11 frameshift mutation in two infants with familial hemophagocytic lymphohistiocytosis type 4 (FHL4). Pediatr Blood Cancer. 2011 Apr; 56(4):654-7. PMID: 21298754.
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    17. Abdelhaleem M. Will helicases contribute to the fight against malaria? Cell Cycle. 2010 Feb 15; 9(4):642. PMID: 20190572.
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    18. Abdelhaleem M. Helicases: an overview. Methods Mol Biol. 2010; 587:1-12. PMID: 20225138.
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    19. Gupta AA, Tyrrell P, Valani R, Benseler S, Abdelhaleem M, Weitzman S. Experience with hemophagocytic lymphohistiocytosis/macrophage activation syndrome at a single institution. J Pediatr Hematol Oncol. 2009 Feb; 31(2):81-4. PMID: 19194188.
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    20. Gupta A, Tyrrell P, Valani R, Benseler S, Weitzman S, Abdelhaleem M. The role of the initial bone marrow aspirate in the diagnosis of hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2008 Sep; 51(3):402-4. PMID: 18523990.
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    21. Al-Jasmi F, Abdelhaleem M, Stockley T, Lee KS, Clarke JT. Novel mutation of the perforin gene and maternal uniparental disomy 10 in a patient with familial hemophagocytic lymphohistiocytosis. J Pediatr Hematol Oncol. 2008 Aug; 30(8):621-4. PMID: 18799942.
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    22. Shah N, Leaker MT, Teshima I, Baruchel S, Abdelhaleem M, Ye CC. Late-appearing Philadelphia chromosome in childhood acute myeloid leukemia. Pediatr Blood Cancer. 2008 May; 50(5):1052-3. PMID: 18213712.
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    23. Bartakke S, Abdelhaleem M, Carcao M. Valproate-induced pure red cell aplasia and megakaryocyte dysplasia. Br J Haematol. 2008 Apr; 141(2):133. PMID: 18353161.
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    24. Gupta A, Weitzman S, Abdelhaleem M. The role of hemophagocytosis in bone marrow aspirates in the diagnosis of hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2008 Feb; 50(2):192-4. PMID: 18061932.
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    25. Abdelhaleem M, Shago M, Sayeh E, Abla O. Childhood myeloid/natural killer precursor acute leukemia with novel chromosomal aberrations der(5)t(4;5)(q31;q31.3) and t(14;17)(q32;q23). Cancer Genet Cytogenet. 2007 Oct 15; 178(2):141-3. PMID: 17954270.
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    26. Abdelhaleem M, Shago M, Beimnet K, Sayeh E, Bartakke S, Weitzman S. Childhood acute myeloid leukemia with hemophagocytosis by the blasts and inv(8)(p11q13) with MOZ-TIF2 fusion transcripts. J Pediatr Hematol Oncol. 2007 Sep; 29(9):643-5. PMID: 17805042.
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    27. Kalbani NA, Weitzman S, Abdelhaleem M, Carcao M, Abla O. Acute lymphoblastic leukemia presenting with gross hematuria. Paediatr Child Health. 2007 Sep; 12(7):573-4. PMID: 19030428.
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    28. Bartakke S, Abdelhaleem M, Abla O. Childhood acute lymphoblastic leukaemia simulating multifocal osteomyelitis. Br J Haematol. 2007 Oct; 139(1):2. PMID: 17711516.
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    29. Abdelhaleem M, Shago M, Abla O. TEL-AML1 fusion in acute lymphoblastic leukemia with L3 morphology. Pediatr Blood Cancer. 2007 Aug; 49(2):217. PMID: 16826562.
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    30. Abdelhaleem M. The expression of cytoplasmic CD79a correlates with surface CD3 expression in childhood T-ALL lymphoblasts. Leuk Res. 2008 Mar; 32(3):511-2. PMID: 17629942.
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    31. Abdelhaleem M. Frequent but nonrandom expression of lymphoid markers on de novo childhood acute myeloid leukemia. Exp Mol Pathol. 2007 Oct; 83(2):259-63. PMID: 17662713.
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    32. Qiao N, Reynaud D, Abdelhaleem M, Pace-Asciak CR. Hepoxilin analogs, PBT-3 and PBT-4, cause apoptosis of Gleevec-resistant K562 cells in vitro. In Vivo. 2007 Mar-Apr; 21(2):267-71. PMID: 17436575.
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    33. Abdelhaleem M, Yi Q, Beimnet K, Grant R. A Novel t(4;11)(q21;q23) MLL-AF4 fusion transcript in infant leukemia. Am J Hematol. 2007 Mar; 82(3):247. PMID: 16924642.
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    34. Abdelhaleem M. Frequent but nonrandom expression of myeloid markers on de novo childhood acute lymphoblastic leukemia. Exp Mol Pathol. 2007 Aug; 83(1):138-41. PMID: 17434163.
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    35. Alli Z, Ho M, Ackerley C, Abdelhaleem M. Characterization of murine Dhx32. Exp Mol Pathol. 2007 Aug; 83(1):115-8. PMID: 17239371.
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    36. Alli Z, Chen Y, Abdul Wajid S, Al-Saud B, Abdelhaleem M. A role for DHX32 in regulating T-cell apoptosis. Anticancer Res. 2007 Jan-Feb; 27(1A):373-7. PMID: 17352256.
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    37. Abdelhaleem M. Cytotoxic granule disruption is a late event in chemotherapy-induced apoptosis in natural killer YT cells. Exp Mol Pathol. 2007 Aug; 83(1):112-4. PMID: 17174951.
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    38. Chen Y, Alli Z, Ackerley C, Al-Saud B, Abdelhaleem M. Altered distribution of heat shock protein 60 (Hsp60) with dysregulated expression of DHX32. Exp Mol Pathol. 2007 Jun; 82(3):256-61. PMID: 17174952.
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    39. Alli Z, Ackerley C, Chen Y, Al-Saud B, Abdelhaleem M. Nuclear and mitochondrial localization of the putative RNA helicase DHX32. Exp Mol Pathol. 2006 Dec; 81(3):245-8. PMID: 16959245.
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    40. Leung EW, Rujkijyanont P, Beyene J, Wei K, Abdelhaleem M, Freedman MH, Dror Y. Shwachman-Diamond syndrome: an inherited model of aplastic anaemia with accelerated angiogenesis. Br J Haematol. 2006 Jun; 133(5):558-61. PMID: 16681645.
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    41. Abla O, Gassas A, Stevens R, Grant R, Abdelhaleem M. bcr-abl-positive T-cell acute lymphoblastic leukemia associated with parvovirus B19 infection. J Pediatr Hematol Oncol. 2006 Feb; 28(2):98-9. PMID: 16462583.
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    42. Crawford MW, Galton S, Abdelhaleem M. Preoperative screening for sickle cell disease in children: clinical implications. Can J Anaesth. 2005 Dec; 52(10):1058-63. PMID: 16326676.
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    43. Alli Z, Nam EH, Beimnet K, Abdelhaleem M. The activation-induced expression of DHX32 in Jurkat T cells is specific and involves calcium and nuclear factor of activated T cells. Cell Immunol. 2005 Oct; 237(2):141-6. PMID: 16414036.
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    44. Alli Z, Ho M, Abdelhaleem M. Expression of DHX32 in lymphoid tissues. Exp Mol Pathol. 2005 Dec; 79(3):219-23. PMID: 16181624.
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    45. Lo B, Li L, Gissen P, Christensen H, McKiernan PJ, Ye C, Abdelhaleem M, Hayes JA, Williams MD, Chitayat D, Kahr WH. Requirement of VPS33B, a member of the Sec1/Munc18 protein family, in megakaryocyte and platelet alpha-granule biogenesis. Blood. 2005 Dec 15; 106(13):4159-66. PMID: 16123220.
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    46. Li X, Qiao N, Reynaud D, Abdelhaleem M, Pace-Asciak CR. PBT-3, a hepoxilin stable analog, causes long term inhibition of growth of K562 solid tumours in vivo. Biochem Biophys Res Commun. 2005 Dec 09; 338(1):158-60. PMID: 16102726.
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    47. Abdelhaleem M, Sun TH, Ho M. DHX32 expression suggests a role in lymphocyte differentiation. Anticancer Res. 2005 Jul-Aug; 25(4):2645-8. PMID: 16080506.
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    48. Abdelhaleem M. RNA helicases: regulators of differentiation. Clin Biochem. 2005 Jun; 38(6):499-503. PMID: 15885226.
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    49. Leung E, Teshima I, Ye C, Grant R, Abdelhaleem M. A der(19)t(12;19)(q12;p13.3) in a case of pediatric acute leukemia with unusual immunophenotype. Cancer Genet Cytogenet. 2005 Mar; 157(2):164-8. PMID: 15721640.
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    50. Li X, Qiao N, Reynaud D, Abdelhaleem M, Pace-Asciak CR. The hepoxilin analog, PBT-3, inhibits growth of K-562 CML solid tumours in vivo in nude mice. In Vivo. 2005 Jan-Feb; 19(1):185-9. PMID: 15796172.
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    51. Abdelhaleem M. Over-expression of RNA helicases in cancer. Anticancer Res. 2004 Nov-Dec; 24(6):3951-3. PMID: 15736437.
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    52. Gupta AA, Grant R, Shago M, Abdelhaleem M. Occurrence of t(8;22)(q24.1;q11.2) involving the MYC locus in a case of pediatric acute lymphoblastic leukemia with a precursor B cell immunophenotype. J Pediatr Hematol Oncol. 2004 Aug; 26(8):532-4. PMID: 15284595.
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    53. Abdelhaleem M. Do human RNA helicases have a role in cancer? Biochim Biophys Acta. 2004 Jul 06; 1704(1):37-46. PMID: 15238243.
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    54. Abla O, Naqvi A, Ye C, Bhattacharjee R, Shago M, Abdelhaleem M, Weitzman S. Leptomeningeal precursor B-cell lymphoblastic lymphoma in a child with minimal bone marrow involvement. J Pediatr Hematol Oncol. 2004 Jul; 26(7):469-72. PMID: 15218426.
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    55. Leung EW, Woodman RC, Roland B, Abdelhaleem M, Freedman MH, Dror Y. Transient myelodysplastic syndrome associated with isochromosome 7q abnormality. Pediatr Hematol Oncol. 2003 Oct-Nov; 20(7):539-45. PMID: 12959859.
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    56. Qiao N, Lam J, Reynaud D, Abdelhaleem M, Pace-Asciak CR. The hepoxilin analog PBT-3 induces apoptosis in BCR-ABL-positive K562 leukemia cells. Anticancer Res. 2003 Sep-Oct; 23(5A):3617-22. PMID: 14666657.
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    57. Sharathkumar A, Kirby M, Freedman M, Abdelhaleem M, Chitayat D, Teshima IE, Dror Y. Malignant hematological disorders in children with Wolf-Hirschhorn syndrome. Am J Med Genet A. 2003 Jun 01; 119A(2):194-9. PMID: 12749063.
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    58. Abdelhaleem M, Maltais L, Wain H. The human DDX and DHX gene families of putative RNA helicases. Genomics. 2003 Jun; 81(6):618-22. PMID: 12782131.
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    59. Leung EW, Vanek W, Abdelhaleem M, Freedman MH, Dror Y. The evolution of juvenile myelomonocytic leukemia in a female patient with paternally inherited neurofibromatosis type 1. J Pediatr Hematol Oncol. 2003 Feb; 25(2):145-7. PMID: 12571467.
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    60. Abdelhaleem M. The actinomycin D-induced apoptosis in BCR-ABL-positive K562 cells is associated with cytoplasmic translocation and cleavage of RNA helicase A. Anticancer Res. 2003 Jan-Feb; 23(1A):485-90. PMID: 12680254.
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    61. Abdelhaleem M. Differential effect of Bcl-xl over-expression on cell death of the monocytic leukemia cell line U937. Anticancer Res. 2002 Nov-Dec; 22(6C):3911-5. PMID: 12553012.
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    62. Abdelhaleem M. The novel helicase homologue DDX32 is down-regulated in acute lymphoblastic leukemia. Leuk Res. 2002 Oct; 26(10):945-54. PMID: 12163057.
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    63. Gesundheit B, Kirby M, Lau W, Koren G, Abdelhaleem M. Thrombocytopenia and megakaryocyte dysplasia: an adverse effect of valproic acid treatment. J Pediatr Hematol Oncol. 2002 Oct; 24(7):589-90. PMID: 12368704.
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    64. Abdelhaleem M. A role for the subcellular localization of Bax in differentiation-induced resistance to apoptosis in HL-60 cells. Anticancer Res. 2002 Jan-Feb; 22(1A):177-81. PMID: 12017283.
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    65. Abdelhaleem MM, Hameed S, Klassen D, Greenberg AH. Leukophysin: an RNA helicase A-related molecule identified in cytotoxic T cell granules and vesicles. J Immunol. 1996 Mar 15; 156(6):2026-35. PMID: 8690889.
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