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Shirley Tse

TitleProgram Director, Staff Rheumatologist
InstitutionThe Hospital for Sick Children
DepartmentRheumatology
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Abe K, Cox A, Takamatsu N, Velez G, Laxer RM, Tse SML, Mahajan VB, Bassuk AG, Fuchs H, Ferguson PJ, Hrabe de Angelis M. Gain-of-function mutations in a member of the Src family kinases cause autoinflammatory bone disease in mice and humans. Proc Natl Acad Sci U S A. 2019 Jun 11; 116(24):11872-11877. PMID: 31138708.
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    2. Chhabra A, Oen K, Huber AM, Shiff NJ, Boire G, Benseler SM, Berard RA, Scuccimarri R, Feldman BM, Lim LSH, Barsalou J, Bruns A, Cabral DA, Chédeville G, Ellsworth J, Houghton K, Lang B, Morishita K, Rumsey DG, Rosenberg AM, Tse SM, Duffy KW, Duffy CM, Guzman J. Real-World Effectiveness of Common Treatment Strategies for Juvenile Idiopathic Arthritis: Results from a Canadian Cohort. Arthritis Care Res (Hoboken). 2019 May 10. PMID: 31074591.
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    3. Gorkem SB, Doria AS, Tse S. Imaging findings of mixed connective tissue disease in children and adolescents: a case series. Jpn J Radiol. 2019 May; 37(5):371-379. PMID: 30875012.
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    4. Swami VG, Jaremko JL, Rumsey DG, Stimec J, Tse SML, Otobo TM, Adams-Webber T, Doria AS. Diagnostic Accuracy of MRI-Based Sacroiliitis Scoring Systems: A Systematic Review. AJR Am J Roentgenol. 2019 Mar 12; 1-14. PMID: 30860884.
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    5. Otobo TM, Conaghan PG, Maksymowych WP, van der Heijde D, Weiss P, Sudol-Szopinska I, Herregods N, Jaremko JL, Meyers AB, Rumsey D, Inarejos EC, Kirkhus E, Stimec J, Panwar J, Thorpe K, Jans L, van Rossum MA, Tolend M, Perez M, Tzaribachev N, Sandhya P, Tse S, Appenzeller S, Swami VG, Touma Z, Lambert R, Doria AS. Preliminary Definitions for Sacroiliac Joint Pathologies in the OMERACT Juvenile Idiopathic Arthritis Magnetic Resonance Imaging Score (OMERACT JAMRIS-SIJ). J Rheumatol. 2019 Feb 15. PMID: 30770500.
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    6. Panwar J, Tse SML, Lim L, Tolend MA, Radhakrishnan S, Salman M, Moineddin R, Doria AS, Stimec J. Spondyloarthritis Research Consortium of Canada Scoring System for Sacroiliitis in Juvenile Spondyloarthritis/Enthesitis-related Arthritis: A Reliability, Validity, and Responsiveness Study. J Rheumatol. 2019 Jun; 46(6):636-644. PMID: 30709956.
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    7. Asmar N, Geerlinks AV, Laxer RM, Tse SML, Dipchand A, Punnett A. Recurrent oral ulcerations following heart transplant in a pediatric patient: A diagnostic dilemma. Pediatr Transplant. 2018 11; 22(7):e13264. PMID: 30003623.
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    8. Farzan N, Vijverberg SJ, Hernandez-Pacheco N, Bel EHD, Berce V, Bønnelykke K, Bisgaard H, Burchard EG, Canino G, Celedón JC, Chew FT, Chiang WC, Cloutier MM, Forno E, Francis B, Hawcutt DB, Herrera-Luis E, Kabesch M, Karimi L, Melén E, Mukhopadhyay S, Merid SK, Palmer CN, Pino-Yanes M, Pirmohamed M, Potocnik U, Repnik K, Schieck M, Sevelsted A, Sio YY, Smyth RL, Soares P, Söderhäll C, Tantisira KG, Tavendale R, Tse SM, Turner S, Verhamme KM, Maitland-van der Zee AH. 17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use. Allergy. 2018 10; 73(10):2083-2088. PMID: 29885281.
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    9. Okihiro A, Hasija R, Fung L, Cameron B, Feldman BM, Laxer R, Schneider R, Silverman E, Spiegel L, Yeung RSM, Tse SML. Development of neoplasms in pediatric patients with rheumatic disease exposed to anti-tumor necrosis factor therapies: a single Centre retrospective study. Pediatr Rheumatol Online J. 2018 Mar 14; 16(1):17. PMID: 29540190.
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    10. Shiff NJ, Tupper S, Oen K, Guzman J, Lim H, Lee CH, Bryce R, Huber AM, Boire G, Dancey P, Feldman B, Laxer R, Miettunen P, Schmeling H, Watanabe Duffy K, Levy DM, Turvey S, Bolaria R, Bruns A, Cabral DA, Campillo S, Chédeville G, Feldman DE, Haddad E, Houghton K, Johnson N, Jurencak R, Lang B, Larche M, Morishita K, Ramsey S, Roth J, Schneider R, Scuccimarri R, Spiegel L, Stringer E, Tse SM, Yeung R, Duffy CM, Tucker LB. Trajectories of pain severity in juvenile idiopathic arthritis: results from the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort. Pain. 2018 01; 159(1):57-66. PMID: 28937578.
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    11. Guzman J, Kerr T, Ward LM, Ma J, Oen K, Rosenberg AM, Feldman BM, Boire G, Houghton K, Dancey P, Scuccimarri R, Bruns A, Huber AM, Watanabe Duffy K, Shiff NJ, Berard RA, Levy DM, Stringer E, Morishita K, Johnson N, Cabral DA, Larché M, Petty RE, Laxer RM, Silverman E, Miettunen P, Chetaille AL, Haddad E, Spiegel L, Turvey SE, Schmeling H, Lang B, Ellsworth J, Ramsey SE, Roth J, Campillo S, Benseler S, Chédeville G, Schneider R, Tse SML, Bolaria R, Gross K, Feldman D, Cameron B, Jurencak R, Dorval J, LeBlanc C, St Cyr C, Gibbon M, Yeung RSM, Duffy CM, Tucker LB. Growth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort. Pediatr Rheumatol Online J. 2017 Aug 22; 15(1):68. PMID: 28830457.
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    12. Cellucci T, Guzman J, Petty RE, Batthish M, Benseler SM, Ellsworth JE, Houghton KM, LeBLANC CM, Huber AM, Luca N, Schmeling H, Shiff NJ, Soon GS, Tse SM. Management of Juvenile Idiopathic Arthritis 2015: A Position Statement from the Pediatric Committee of the Canadian Rheumatology Association. J Rheumatol. 2016 10; 43(10):1773-1776. PMID: 27698103.
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    13. Race DL, Sims-Gould J, Tucker LB, Duffy CM, Feldman DE, Gibbon M, Houghton KM, Stinson JN, Stringer E, Tse SM, McKay HA. 'It might hurt, but you have to push through the pain': Perspectives on physical activity from children with juvenile idiopathic arthritis and their parents. J Child Health Care. 2016 Dec; 20(4):428-436. PMID: 26907570.
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    14. Zahedi Niaki O, Clarke AE, Ramsey-Goldman R, Yeung R, Hayward K, Oen K, Duffy CM, Rosenberg A, O'Neil KM, von Scheven E, Schanberg L, Labrecque J, Tse SM, Hasija R, Lee JL, Bernatsky S. Malignancy incidence in 5294 patients with juvenile arthritis. RMD Open. 2016; 2(1):e000212. PMID: 27175293.
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    15. Burgos-Vargas R, Tse SM, Horneff G, Pangan AL, Kalabic J, Goss S, Unnebrink K, Anderson JK. A Randomized, Double-Blind, Placebo-Controlled Multicenter Study of Adalimumab in Pediatric Patients With Enthesitis-Related Arthritis. Arthritis Care Res (Hoboken). 2015 Nov; 67(11):1503-12. PMID: 26223543.
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    16. Guzman J, Oen K, Huber AM, Watanabe Duffy K, Boire G, Shiff N, Berard RA, Levy DM, Stringer E, Scuccimarri R, Morishita K, Johnson N, Cabral DA, Rosenberg AM, Larché M, Dancey P, Petty RE, Laxer RM, Silverman E, Miettunen P, Chetaille AL, Haddad E, Houghton K, Spiegel L, Turvey SE, Schmeling H, Lang B, Ellsworth J, Ramsey SE, Bruns A, Roth J, Campillo S, Benseler S, Chédeville G, Schneider R, Tse SM, Bolaria R, Gross K, Feldman B, Feldman D, Cameron B, Jurencak R, Dorval J, LeBlanc C, St Cyr C, Gibbon M, Yeung RS, Duffy CM, Tucker LB. The risk and nature of flares in juvenile idiopathic arthritis: results from the ReACCh-Out cohort. Ann Rheum Dis. 2016 06; 75(6):1092-8. PMID: 25985972.
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    17. Al-Adba B, Tse SM. Radiographic manifestations in Pfeiffer syndrome. Arthritis Rheumatol. 2015 May; 67(8):2282. PMID: 25892094.
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    18. Aquino MR, Tse SM, Gupta S, Rachlis AC, Stimec J. Whole-body MRI of juvenile spondyloarthritis: protocols and pictorial review of characteristic patterns. Pediatr Radiol. 2015 Apr; 45(5):754-62. PMID: 25896337.
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    19. Rohekar S, Chan J, Tse SM, Haroon N, Chandran V, Bessette L, Mosher D, Flanagan C, Keen KJ, Adams K, Mallinson M, Thorne C, Rahman P, Gladman DD, Inman RD. 2014 Update of the Canadian Rheumatology Association/Spondyloarthritis Research Consortium of Canada Treatment Recommendations for the Management of Spondyloarthritis. Part II: Specific Management Recommendations. J Rheumatol. 2015 Apr; 42(4):665-81. PMID: 25684768.
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    20. Rohekar S, Chan J, Tse SM, Haroon N, Chandran V, Bessette L, Mosher D, Flanagan C, Keen KJ, Adams K, Mallinson M, Thorne C, Rahman P, Gladman DD, Inman RD. 2014 Update of the Canadian Rheumatology Association/spondyloarthritis research consortium of Canada treatment recommendations for the management of spondyloarthritis. Part I: principles of the management of spondyloarthritis in Canada. J Rheumatol. 2015 Apr; 42(4):654-64. PMID: 25684770.
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    21. Batthish M, Tse SM, Feldman BM, Baker GR, Laxer RM. Trying to improve care: the Morbidity and Mortality Conference in a division of rheumatology. J Rheumatol. 2014 Dec; 41(12):2452-8. PMID: 25362651.
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    22. Guzman J, Oen K, Tucker LB, Huber AM, Shiff N, Boire G, Scuccimarri R, Berard R, Tse SM, Morishita K, Stringer E, Johnson N, Levy DM, Duffy KW, Cabral DA, Rosenberg AM, Larché M, Dancey P, Petty RE, Laxer RM, Silverman E, Miettunen P, Chetaille AL, Haddad E, Houghton K, Spiegel L, Turvey SE, Schmeling H, Lang B, Ellsworth J, Ramsey S, Bruns A, Campillo S, Benseler S, Chédeville G, Schneider R, Yeung R, Duffy CM. The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort. Ann Rheum Dis. 2015 Oct; 74(10):1854-60. PMID: 24842571.
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    23. Hugle B, Burgos-Vargas R, Inman RD, O'Shea F, Laxer RM, Stimec J, Whitney-Mahoney K, Duvnjak M, Anderson M, Tse SM. Long-term outcome of anti-tumor necrosis factor alpha blockade in the treatment of juvenile spondyloarthritis. Clin Exp Rheumatol. 2014 May-Jun; 32(3):424-31. PMID: 24387974.
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    24. Rumsey DG, Temple M, Borschel G, Tse SM. Ischemic reaction secondary to corticosteroid injection of the joint. Arthritis Rheum. 2013 Aug; 65(8):2189. PMID: 23606212.
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    25. Batthish M, Bassilious E, Schneider R, Feldman BM, Hyman A, Tse SM. A unique, interactive and web-based pediatric rheumatology teaching module: residents' perceptions. Pediatr Rheumatol Online J. 2013 May 27; 11(1):22. PMID: 23710693.
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    26. Greenwald AG, Zakerzadeh A, Laxer RM, Schneider R, Cameron B, Feldman B, Spiegel L, Tse SM, Silverman ED. Later-onset rheumatoid factor negative polyarticular juvenile idiopathic arthritis (JIA): a unique patient group? Clin Exp Rheumatol. 2013 Jul-Aug; 31(4):645-52. PMID: 23622111.
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    27. Butbul Aviel Y, Tyrrell P, Schneider R, Dhillon S, Feldman BM, Laxer R, Saurenmann RK, Spiegel L, Cameron B, Tse SM, Silverman E. Juvenile Psoriatic Arthritis (JPsA): juvenile arthritis with psoriasis? Pediatr Rheumatol Online J. 2013 Mar 15; 11(1):11. PMID: 23497068.
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    28. Coltin H, Soon GS, Luca N, Tse SM. Case 2: A 14-year-old girl with oral and genital ulcers. Paediatr Child Health. 2013 Jan; 18(1):33-5. PMID: 24381491.
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    29. Leblanc CM, Lang B, Bencivenga A, Chetaille AL, Dancey P, Dent P, Miettunen P, Oen K, Rosenberg A, Roth J, Scuccimarri R, Tse SM, Benseler S, Cabral DA, Campillo S, Chédeville G, Duffy CM, Duffy KW, Haddad E, Huber AM, Laxer R, Levy D, Johnson N, Ramsey S, Shiff N, Schmeling H, Schneider R, Stringer E, Yeung RS, Tucker LB. Access to biologic therapies in Canada for children with juvenile idiopathic arthritis. J Rheumatol. 2012 Sep; 39(9):1875-9. PMID: 22859344.
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    30. Cellucci T, Tse SM, Shroff M. Case 2: A pain in the neck. Paediatr Child Health. 2012 May; 17(5):247-50. PMID: 23633899.
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    31. Tse SM, Burgos-Vargas R, Colbert RA. Juvenile spondyloarthritis treatment recommendations. Am J Med Sci. 2012 May; 343(5):367-70. PMID: 22543540.
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    32. Tse SM, Laxer RM. New advances in juvenile spondyloarthritis. Nat Rev Rheumatol. 2012 Apr 10; 8(5):269-79. PMID: 22487801.
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    33. Stinson JN, Connelly M, Jibb LA, Schanberg LE, Walco G, Spiegel LR, Tse SM, Chalom EC, Chira P, Rapoff M. Developing a standardized approach to the assessment of pain in children and youth presenting to pediatric rheumatology providers: a Delphi survey and consensus conference process followed by feasibility testing. Pediatr Rheumatol Online J. 2012 Apr 10; 10(1):7. PMID: 22490427.
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    34. Gowdie PJ, Tse SM. Juvenile idiopathic arthritis. Pediatr Clin North Am. 2012 Apr; 59(2):301-27. PMID: 22560572.
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    35. Stinson JN, Feldman BM, Duffy CM, Huber AM, Tucker LB, McGrath PJ, Tse SM, Hetherington R, Spiegel LR, Campillo S, Benseler S, Gill N, White ME, Baker N, Vijenthira A. Jointly managing arthritis: information needs of children with juvenile idiopathic arthritis (JIA) and their parents. J Child Health Care. 2012 Jun; 16(2):124-40. PMID: 22308541.
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    36. Luca NJ, Soon GS, Tse SM. Case 1: Acute chorea. Paediatr Child Health. 2011 Dec; 16(10):643-5. PMID: 23204905.
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    37. Butbul Aviel Y, Stremler R, Benseler SM, Cameron B, Laxer RM, Ota S, Schneider R, Spiegel L, Stinson JN, Tse SM, Feldman BM. Sleep and fatigue and the relationship to pain, disease activity and quality of life in juvenile idiopathic arthritis and juvenile dermatomyositis. Rheumatology (Oxford). 2011 Nov; 50(11):2051-60. PMID: 21873265.
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    38. Stinson J, McGrath P, Hodnett E, Feldman B, Duffy C, Huber A, Tucker L, Hetherington R, Tse S, Spiegel L, Campillo S, Gill N, White M. Usability testing of an online self-management program for adolescents with juvenile idiopathic arthritis. J Med Internet Res. 2010 Jul 29; 12(3):e30. PMID: 20675293.
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    39. Stinson JN, McGrath PJ, Hodnett ED, Feldman BM, Duffy CM, Huber AM, Tucker LB, Hetherington CR, Tse SM, Spiegel LR, Campillo S, Gill NK, White ME. An internet-based self-management program with telephone support for adolescents with arthritis: a pilot randomized controlled trial. J Rheumatol. 2010 Sep; 37(9):1944-52. PMID: 20595280.
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    40. Ardelean DS, Gonska T, Wires S, Cutz E, Griffiths A, Harvey E, Tse SM, Benseler SM. Severe ulcerative colitis after rituximab therapy. Pediatrics. 2010 Jul; 126(1):e243-6. PMID: 20566611.
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    41. Oen K, Duffy CM, Tse SM, Ramsey S, Ellsworth J, Chédeville G, Chetaille AL, Saint-Cyr C, Cabral DA, Spiegel LR, Schneider R, Lang B, Huber AM, Dancey P, Silverman E, Rosenberg AM, Cameron B, Johnson N, Dorval J, Scuccimarri R, Campillo S, Petty RE, Duffy KN, Boire G, Haddad E, Houghton K, Laxer R, Turvey SE, Miettunen P, Gross K, Guzman J, Benseler S, Feldman BM, Espinosa V, Yeung RS, Tucker L. Early outcomes and improvement of patients with juvenile idiopathic arthritis enrolled in a Canadian multicenter inception cohort. Arthritis Care Res (Hoboken). 2010 Apr; 62(4):527-36. PMID: 20391508.
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    42. Oen K, Tucker L, Huber AM, Miettunen P, Scuccimarri R, Campillo S, Cabral DA, Feldman BM, Tse S, Chédeville G, Spiegel L, Schneider R, Lang B, Ellsworth J, Ramsey S, Dancey P, Silverman E, Chetaille AL, Cameron B, Johnson N, Dorval J, Petty RE, Duffy KW, Boire G, Haddad E, Houghton K, Saint-Cyr C, Turvey SE, Benseler S, Cheang M, Yeung RS, Duffy CM. Predictors of early inactive disease in a juvenile idiopathic arthritis cohort: results of a Canadian multicenter, prospective inception cohort study. Arthritis Rheum. 2009 Aug 15; 61(8):1077-86. PMID: 19644903.
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    43. Butbul YA, Tyrrell PN, Schneider R, Dhillon S, Feldman BM, Laxer RM, Saurenmann RK, Spiegel L, Cameron B, Tse SM, Silverman ED. Comparison of patients with juvenile psoriatic arthritis and nonpsoriatic juvenile idiopathic arthritis: how different are they? J Rheumatol. 2009 Sep; 36(9):2033-41. PMID: 19648305.
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    44. Stephens S, Feldman BM, Bradley N, Schneiderman J, Wright V, Singh-Grewal D, Lefebvre A, Benseler SM, Cameron B, Laxer R, O'Brien C, Schneider R, Silverman E, Spiegel L, Stinson J, Tyrrell PN, Whitney K, Tse SM. Feasibility and effectiveness of an aerobic exercise program in children with fibromyalgia: results of a randomized controlled pilot trial. Arthritis Rheum. 2008 Oct 15; 59(10):1399-406. PMID: 18821656.
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    45. O'Shea FD, Boyle E, Riarh R, Tse SM, Laxer RM, Inman RD. Comparison of clinical and radiographic severity of juvenile-onset versus adult-onset ankylosing spondylitis. Ann Rheum Dis. 2009 Sep; 68(9):1407-12. PMID: 18782793.
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    46. Stephens S, Singh-Grewal D, Bar-Or O, Beyene J, Cameron B, Leblanc CM, Schneider R, Schneiderman-Walker J, Selvadurai H, Silverman E, Spiegel L, Tse SM, Wright V, Feldman BM. Reliability of exercise testing and functional activity questionnaires in children with juvenile arthritis. Arthritis Rheum. 2007 Dec 15; 57(8):1446-52. PMID: 18050186.
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    47. Singh-Grewal D, Schneiderman-Walker J, Wright V, Bar-Or O, Beyene J, Selvadurai H, Cameron B, Laxer RM, Schneider R, Silverman ED, Spiegel L, Tse S, Leblanc C, Wong J, Stephens S, Feldman BM. The effects of vigorous exercise training on physical function in children with arthritis: a randomized, controlled, single-blinded trial. Arthritis Rheum. 2007 Oct 15; 57(7):1202-10. PMID: 17907238.
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    48. Tse SM, Laxer RM, Babyn PS, Doria AS. Radiologic Improvement of juvenile idiopathic arthritis-enthesitis-related arthritis following anti-tumor necrosis factor-alpha blockade with etanercept. J Rheumatol. 2006 Jun; 33(6):1186-8. PMID: 16755667.
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    49. Tse SM, Laxer RM. Approach to acute limb pain in childhood. Pediatr Rev. 2006 May; 27(5):170-9; quiz 180. PMID: 16651274.
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    50. Avcin T, Tse SM, Schneider R, Ngan B, Silverman ED. Macrophage activation syndrome as the presenting manifestation of rheumatic diseases in childhood. J Pediatr. 2006 May; 148(5):683-6. PMID: 16737887.
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    51. Tse SM, Burgos-Vargas R, Laxer RM. Anti-tumor necrosis factor alpha blockade in the treatment of juvenile spondylarthropathy. Arthritis Rheum. 2005 Jul; 52(7):2103-8. PMID: 15986366.
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    52. Tse SM, Mason D, Botelho RJ, Chiu B, Reyland M, Hanada K, Inman RD, Grinstein S. Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis. J Biol Chem. 2005 Jul 01; 280(26):25210-5. PMID: 15863503.
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    53. Tse SM, Laxer RM. Juvenile spondyloarthropathy. Curr Opin Rheumatol. 2003 Jul; 15(4):374-9. PMID: 12819463.
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    54. Tse SM, Furuya W, Gold E, Schreiber AD, Sandvig K, Inman RD, Grinstein S. Differential role of actin, clathrin, and dynamin in Fc gamma receptor-mediated endocytosis and phagocytosis. J Biol Chem. 2003 Jan 31; 278(5):3331-8. PMID: 12424246.
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    55. Tse SM, Silverman ED, McCrindle BW, Yeung RS. Early treatment with intravenous immunoglobulin in patients with Kawasaki disease. J Pediatr. 2002 Apr; 140(4):450-5. PMID: 12006960.
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    56. Tse S, Lubelsky S, Gordon M, Al Mayouf SM, Babyn PS, Laxer RM, Silverman ED, Schneider R, Feldman BM. The arthritis of inflammatory childhood myositis syndromes. J Rheumatol. 2001 Jan; 28(1):192-7. PMID: 11196524.
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    57. Tse S, Saunders EF, Silverman E, Vajsar J, Becker L, Meaney B. Myasthenia gravis and polymyositis as manifestations of chronic graft-versus-host-disease. Bone Marrow Transplant. 1999 Feb; 23(4):397-9. PMID: 10100585.
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    58. Tse S, Barrington K, Byrne P. Methemoglobinemia associated with prilocaine use in neonatal circumcision. Am J Perinatol. 1995 Sep; 12(5):331-2. PMID: 8540935.
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    59. Horner RL, Brooks D, Kozar LF, Tse S, Phillipson EA. Immediate effects of arousal from sleep on cardiac autonomic outflow in the absence of breathing in dogs. J Appl Physiol (1985). 1995 Jul; 79(1):151-62. PMID: 7559214.
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    60. Ryan CA, Wenman W, Henningsen C, Tse S. Fatal childhood pneumococcal Waterhouse-Friderichsen syndrome. Pediatr Infect Dis J. 1993 Mar; 12(3):250-1. PMID: 8451106.
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    61. Abel SM, Tse SM. The nucleus implant: rehabilitation and results. J Otolaryngol. 1987 Oct; 16(5):295-9. PMID: 3682050.
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