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Chris Macgowan

TitleSenior Scientist (Imaging)
InstitutionThe Hospital for Sick Children
DepartmentTranslational Medicine
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
ORCID ORCID Icon0000-0002-7016-0662 Additional info
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Goolaub DS, Roy CW, Schrauben E, Sussman D, Marini D, Seed M, Macgowan CK. Multidimensional fetal flow imaging with cardiovascular magnetic resonance: a feasibility study. J Cardiovasc Magn Reson. 2018 Nov 29; 20(1):77. PMID: 30486832.
      View in: PubMed
    2. Roy CW, Macgowan CK. Dynamic MRI of a Large Fetal Cardiac Mass. Radiology. 2018 Nov 20; 182025. PMID: 30457477.
      View in: PubMed
    3. Jørgensen DES, Tabor A, Rode L, Dyre L, Ekelund CK, Hellmuth SG, Macgowan CK, Nørgaard LN, Seed M, Sundberg K, Søgaard K, Jensen LN, Vejlstrup N. Longitudinal Brain and Body Growth in Fetuses With and Without Transposition of the Great Arteries. Circulation. 2018 Sep 25; 138(13):1368-1370. PMID: 30354424.
      View in: PubMed
    4. Duan AQ, Darby JRT, Soo JY, Lock MC, Zhu MY, Flynn LV, Perumal SR, Macgowan CK, Selvanayagam JB, Morrison JL, Seed M. Feasibility of phase-contrast cine magnetic resonance imaging for measuring blood flow in the sheep fetus. Am J Physiol Regul Integr Comp Physiol. 2017 Dec 13. PMID: 29351431.
      View in: PubMed
    5. Sun L, Macgowan CK, Portnoy S, Sled JG, Yoo SJ, Grosse-Wortmann L, Jaeggi E, Kingdom J, Seed M. New advances in fetal cardiovascular magnetic resonance imaging for quantifying the distribution of blood flow and oxygen transport: Potential applications in fetal cardiovascular disease diagnosis and therapy. Echocardiography. 2017 12; 34(12):1799-1803. PMID: 29287129.
      View in: PubMed
    6. Portnoy S, Milligan N, Seed M, Sled JG, Macgowan CK. Human umbilical cord blood relaxation times and susceptibility at 3 T. Magn Reson Med. 2018 Jun; 79(6):3194-3206. PMID: 29067745.
      View in: PubMed
    7. Cahill LS, Rennie MY, Hoggarth J, Yu LX, Rahman A, Kingdom JC, Seed M, Macgowan CK, Sled JG. Feto- and utero-placental vascular adaptations to chronic maternal hypoxia in the mouse. J Physiol. 2018 Aug; 596(15):3285-3297. PMID: 28861917.
      View in: PubMed
    8. Duan AQ, Lock MC, Perumal SR, Darby JR, Soo JY, Selvanayagam JB, Macgowan CK, Seed M, Morrison JL. Feasibility of detecting myocardial infarction in the sheep fetus using late gadolinium enhancement CMR imaging. J Cardiovasc Magn Reson. 2017 Sep 13; 19(1):69. PMID: 28903760.
      View in: PubMed
    9. Robertson AD, Matta G, Basile VS, Black SE, Macgowan CK, Detre JA, MacIntosh BJ. Temporal and Spatial Variances in Arterial Spin-Labeling Are Inversely Related to Large-Artery Blood Velocity. AJNR Am J Neuroradiol. 2017 Aug; 38(8):1555-1561. PMID: 28619834.
      View in: PubMed
    10. Rahman A, Cahill LS, Zhou YQ, Hoggarth J, Rennie MY, Seed M, Macgowan CK, Kingdom JC, Adamson SL, Sled JG. A mouse model of antepartum stillbirth. Am J Obstet Gynecol. 2017 10; 217(4):443.e1-443.e11. PMID: 28619691.
      View in: PubMed
    11. Rahman A, Zhou YQ, Yee Y, Dazai J, Cahill LS, Kingdom J, Macgowan CK, Sled JG. Ultrasound detection of altered placental vascular morphology based on hemodynamic pulse wave reflection. Am J Physiol Heart Circ Physiol. 2017 May 01; 312(5):H1021-H1029. PMID: 28364018.
      View in: PubMed
    12. Roy CW, Seed M, Kingdom JC, Macgowan CK. Motion compensated cine CMR of the fetal heart using radial undersampling and compressed sensing. J Cardiovasc Magn Reson. 2017 Mar 20; 19(1):29. PMID: 28316282.
      View in: PubMed
    13. Portnoy S, Seed M, Sled JG, Macgowan CK. Non-invasive evaluation of blood oxygen saturation and hematocrit from T1 and T2 relaxation times: In-vitro validation in fetal blood. Magn Reson Med. 2017 Dec; 78(6):2352-2359. PMID: 28191646.
      View in: PubMed
    14. Cahill LS, Hoggarth J, Lerch JP, Seed M, Macgowan CK, Sled JG. Fetal brain sparing in a mouse model of chronic maternal hypoxia. J Cereb Blood Flow Metab. 2017 Jan 01; 271678X17750324. PMID: 29271304.
      View in: PubMed
    15. Roy CW, Seed M, Macgowan CK. Accelerated MRI of the fetal heart using compressed sensing and metric optimized gating. Magn Reson Med. 2017 06; 77(6):2125-2135. PMID: 27254315.
      View in: PubMed
    16. Lim JM, Kingdom T, Saini B, Chau V, Post M, Blaser S, Macgowan C, Miller SP, Seed M. Cerebral oxygen delivery is reduced in newborns with congenital heart disease. J Thorac Cardiovasc Surg. 2016 10; 152(4):1095-103. PMID: 27349283.
      View in: PubMed
    17. Portnoy S, Osmond M, Zhu MY, Seed M, Sled JG, Macgowan CK. Relaxation properties of human umbilical cord blood at 1.5 Tesla. Magn Reson Med. 2017 04; 77(4):1678-1690. PMID: 27059881.
      View in: PubMed
    18. Porayette P, Madathil S, Sun L, Jaeggi E, Grosse-Wortmann L, Yoo SJ, Hickey E, Miller SP, Macgowan CK, Seed M. MRI reveals hemodynamic changes with acute maternal hyperoxygenation in human fetuses with and without congenital heart disease. Prenat Diagn. 2016 Mar; 36(3):274-81. PMID: 26701792.
      View in: PubMed
    19. Sun L, Macgowan CK, Sled JG, Yoo SJ, Manlhiot C, Porayette P, Grosse-Wortmann L, Jaeggi E, McCrindle B, Kingdom J, Hickey E, Miller S, Seed M. Response to Letter Regarding Article, "Reduced Fetal Cerebral Oxygen Consumption Is Associated With Smaller Brain Size in Fetuses With Congenital Heart Disease". Circulation. 2016 Jan 05; 133(1):e8. PMID: 26719396.
      View in: PubMed
    20. Zhu MY, Jaeggi E, Roy CW, Macgowan CK, Seed M. Reduced combined ventricular output and increased oxygen extraction fraction in a fetus with complete heart block demonstrated by MRI. HeartRhythm Case Rep. 2016 Mar; 2(2):164-168. PMID: 28491659.
      View in: PubMed
    21. Zhu MY, Milligan N, Keating S, Windrim R, Keunen J, Thakur V, Ohman A, Portnoy S, Sled JG, Kelly E, Yoo SJ, Gross-Wortmann L, Jaeggi E, Macgowan CK, Kingdom JC, Seed M. The hemodynamics of late-onset intrauterine growth restriction by MRI. Am J Obstet Gynecol. 2016 Mar; 214(3):367.e1-367.e17. PMID: 26475425.
      View in: PubMed
    22. Tsai-Goodman B, Zhu MY, Al-Rujaib M, Seed M, Macgowan CK. Foetal blood flow measured using phase contrast cardiovascular magnetic resonance--preliminary data comparing 1.5 T with 3.0 T. J Cardiovasc Magn Reson. 2015 Apr 18; 17:30. PMID: 25928450; PMCID: PMC4404231.
    23. Sun L, Macgowan CK, Sled JG, Yoo SJ, Manlhiot C, Porayette P, Grosse-Wortmann L, Jaeggi E, McCrindle BW, Kingdom J, Hickey E, Miller S, Seed M. Reduced fetal cerebral oxygen consumption is associated with smaller brain size in fetuses with congenital heart disease. Circulation. 2015 Apr 14; 131(15):1313-23. PMID: 25762062; PMCID: PMC4398654.
    24. Macgowan CK, Stoops SJ, Zhou YQ, Cahill LS, Sled JG. Evaluation of cerebrovascular impedance and wave reflection in mouse by ultrasound. J Cereb Blood Flow Metab. 2015 Mar; 35(3):521-6. PMID: 25515209; PMCID: PMC4348395.
    25. Borik S, Macgowan CK, Seed M. Maternal hyperoxygenation and foetal cardiac MRI in the assessment of the borderline left ventricle. Cardiol Young. 2015 Aug; 25(6):1214-7. PMID: 25275342.
      View in: PubMed
    26. Zhou YQ, Cahill LS, Wong MD, Seed M, Macgowan CK, Sled JG. Assessment of flow distribution in the mouse fetal circulation at late gestation by high-frequency Doppler ultrasound. Physiol Genomics. 2014 Aug 15; 46(16):602-14. PMID: 24963005.
      View in: PubMed
    27. Porayette P, van Amerom JF, Yoo SJ, Jaeggi E, Macgowan CK, Seed M. MRI shows limited mixing between systemic and pulmonary circulations in foetal transposition of the great arteries: a potential cause of in utero pulmonary vascular disease. Cardiol Young. 2015 Apr; 25(4):737-44. PMID: 24932863; PMCID: PMC4411741.
    28. Prsa M, Sun L, van Amerom J, Yoo SJ, Grosse-Wortmann L, Jaeggi E, Macgowan C, Seed M. Reference ranges of blood flow in the major vessels of the normal human fetal circulation at term by phase-contrast magnetic resonance imaging. Circ Cardiovasc Imaging. 2014 Jul; 7(4):663-70. PMID: 24874055.
      View in: PubMed
    29. Cahill LS, Zhou YQ, Seed M, Macgowan CK, Sled JG. Brain sparing in fetal mice: BOLD MRI and Doppler ultrasound show blood redistribution during hypoxia. J Cereb Blood Flow Metab. 2014 Jun; 34(6):1082-8. PMID: 24714036; PMCID: PMC4050255.
    30. Shariat M, Schantz D, Yoo SJ, Wintersperger BJ, Seed M, Alnafisi B, Chu L, Macgowan CK, van Amerom J, Grosse-Wortmann L. Pulmonary artery pulsatility and effect on vessel diameter assessment in magnetic resonance imaging. Eur J Radiol. 2014 Feb; 83(2):378-83. PMID: 24176531.
      View in: PubMed
    31. Macgowan CK, Chan KY, Laughlin S, Marrie RA, Banwell B. Cerebral arterial and venous blood flow in adolescent multiple sclerosis patients and age-matched controls using phase contrast MRI. J Magn Reson Imaging. 2014 Aug; 40(2):341-7. PMID: 24115149.
      View in: PubMed
    32. Al Nafisi B, van Amerom JF, Forsey J, Jaeggi E, Grosse-Wortmann L, Yoo SJ, Macgowan CK, Seed M. Fetal circulation in left-sided congenital heart disease measured by cardiovascular magnetic resonance: a case-control study. J Cardiovasc Magn Reson. 2013 Jul 27; 15:65. PMID: 23890187; PMCID: PMC3735489.
    33. Laughlin S, Macgowan CK, Traubici J, Chan K, Khan S, Arnold DL, Marrie RA, Banwell B. No evidence for impairment of venous hemodynamics in children or young adults with pediatric-onset multiple sclerosis. AJNR Am J Neuroradiol. 2013 Dec; 34(12):2366-72. PMID: 23868149.
      View in: PubMed
    34. Roy CW, Seed M, van Amerom JF, Al Nafisi B, Grosse-Wortmann L, Yoo SJ, Macgowan CK. Dynamic imaging of the fetal heart using metric optimized gating. Magn Reson Med. 2013 Dec; 70(6):1598-607. PMID: 23382068.
      View in: PubMed
    35. Seed M, van Amerom JF, Yoo SJ, Al Nafisi B, Grosse-Wortmann L, Jaeggi E, Jansz MS, Macgowan CK. Feasibility of quantification of the distribution of blood flow in the normal human fetal circulation using CMR: a cross-sectional study. J Cardiovasc Magn Reson. 2012 Nov 26; 14:79. PMID: 23181717; PMCID: PMC3534594.
    36. Grosse-Wortmann L, Yoo SJ, Solomon M, Macgowan CK, Keshavjee S, Grasemann H. Cardiopulmonary magnetic resonance imaging in children after lung transplantation: preliminary observations. J Heart Lung Transplant. 2011 Nov; 30(11):1294-8. PMID: 21856174.
      View in: PubMed
    37. Sun AM, AlHabshan F, Cheung M, Bronzetti G, Redington AN, Benson LN, Macgowan C, Yoo SJ. Delayed onset of tricuspid valve flow in repaired tetralogy of Fallot: an additional mechanism of diastolic dysfunction and interventricular dyssynchrony. J Cardiovasc Magn Reson. 2011 Aug 24; 13:43. PMID: 21864332; PMCID: PMC3173350.
    38. Jansz MS, Seed M, van Amerom JF, Wong D, Grosse-Wortmann L, Yoo SJ, Macgowan CK. Metric optimized gating for fetal cardiac MRI. Magn Reson Med. 2010 Nov; 64(5):1304-14. PMID: 20632406.
      View in: PubMed
    39. Macgowan CK, Liu GK, van Amerom JF, Sussman MS, Wright GA. Self-gated Fourier velocity encoding. Magn Reson Imaging. 2010 Jan; 28(1):95-102. PMID: 19553052.
      View in: PubMed
    40. van Amerom JF, Vidarsson L, Wu S, Tessler R, Yoo SJ, Belik J, Macgowan CK. Regional pulmonary blood flow: Comparison of dynamic contrast-enhanced MR perfusion and phase-contrast MR. Magn Reson Med. 2009 May; 61(5):1249-54. PMID: 19253385.
      View in: PubMed
    41. Goo HW, Al-Otay A, Grosse-Wortmann L, Wu S, Macgowan CK, Yoo SJ. Phase-contrast magnetic resonance quantification of normal pulmonary venous return. J Magn Reson Imaging. 2009 Mar; 29(3):588-94. PMID: 19243041.
      View in: PubMed
    42. Widjaja E, Wei X, Vidarsson L, Moineddin R, Macgowan CK, Nilsson D. Alteration of diffusion tensor parameters in postmortem brain. Magn Reson Imaging. 2009 Jul; 27(6):865-70. PMID: 19152773.
      View in: PubMed
    43. Tessler R, Wu S, Fiori R, Macgowan CK, Belik J. Sildenafil acutely reverses the hypoxic pulmonary vasoconstriction response of the newborn pig. Pediatr Res. 2008 Sep; 64(3):251-5. PMID: 18458659.
      View in: PubMed
    44. van Amerom JF, Kellenberger CJ, Yoo SJ, Macgowan CK. Automated measurement and classification of pulmonary blood-flow velocity patterns using phase-contrast MRI and correlation analysis. Magn Reson Imaging. 2009 Jan; 27(1):38-47. PMID: 18650044.
      View in: PubMed
    45. Vidarsson L, Helm E, O'Brodovich H, Macgowan CK. Visualizing water clearance in the lung with MRI. Magn Reson Med. 2008 Jul; 60(1):230-5. PMID: 18581395.
      View in: PubMed
    46. Grosse-Wortmann L, Macgowan CK, Vidarsson L, Yoo SJ. Late gadolinium enhancement of the right ventricular myocardium: is it really different from the left ? J Cardiovasc Magn Reson. 2008 May 08; 10:20. PMID: 18466606; PMCID: PMC2430565.
    47. Grosse-Wortmann L, Al-Otay A, Goo HW, Macgowan CK, Coles JG, Benson LN, Redington AN, Yoo SJ. Anatomical and functional evaluation of pulmonary veins in children by magnetic resonance imaging. J Am Coll Cardiol. 2007 Mar 06; 49(9):993-1002. PMID: 17336724.
      View in: PubMed
    48. Crawford MW, Arrica M, Macgowan CK, Yoo SJ. Extent and localization of changes in upper airway caliber with varying concentrations of sevoflurane in children. Anesthesiology. 2006 Dec; 105(6):1147-52; discussion 5A. PMID: 17122577.
      View in: PubMed
    49. Roman KS, Nii M, Macgowan CK, Barrea C, Coles J, Smallhorn JF. The impact of patch augmentation on left atrioventricular valve dynamics in patients with atrioventricular septal defects: early and midterm follow-up. J Am Soc Echocardiogr. 2006 Nov; 19(11):1382-92. PMID: 17098142.
      View in: PubMed
    50. Yoo S-J, Kellenberger CJ, Roman KS, Al-Habshan F, Branson H, Sun A-M, Macgowan CK. . Magnetic Resonance Evaluation of Pulmonary Circulation in Children. Prog. Pediatr. Cardiol. 2006; 22(2):211-223.
    51. Crawford MW, Rohan D, Macgowan CK, Yoo SJ, Macpherson BA. Effect of propofol anesthesia and continuous positive airway pressure on upper airway size and configuration in infants. Anesthesiology. 2006 Jul; 105(1):45-50. PMID: 16809993.
      View in: PubMed
    52. Nii M, Guerra V, Roman KS, Macgowan CK, Smallhorn JF. Three-dimensional tricuspid annular function provides insight into the mechanisms of tricuspid valve regurgitation in classic hypoplastic left heart syndrome. J Am Soc Echocardiogr. 2006 Apr; 19(4):391-402. PMID: 16581478.
      View in: PubMed
    53. Kellenberger CJ, Macgowan CK, Roman KS, Al-Habshan F, Benson LN, Redington AN, Yoo SJ. Hemodynamic evaluation of the peripheral pulmonary circulation by cine phase-contrast magnetic resonance imaging. J Magn Reson Imaging. 2005 Dec; 22(6):780-7. PMID: 16270288.
      View in: PubMed
    54. Nii M, Roman KS, Macgowan CK, Smallhorn JF. Insight into normal mitral and tricuspid annular dynamics in pediatrics: a real-time three-dimensional echocardiographic study. J Am Soc Echocardiogr. 2005 Aug; 18(8):805-14. PMID: 16084332.
      View in: PubMed
    55. Macgowan CK, Al-Kwifi O, Varodayan F, Yoo SJ, Wright GA, Kellenberger CJ. Optimization of 3D contrast-enhanced pulmonary magnetic resonance angiography in pediatric patients with congenital heart disease. Magn Reson Med. 2005 Jul; 54(1):207-12. PMID: 15968668.
      View in: PubMed
    56. Macgowan CK, Kellenberger CJ, Detsky JS, Roman K, Yoo SJ. Real-time Fourier velocity encoding: an in vivo evaluation. J Magn Reson Imaging. 2005 Mar; 21(3):297-304. PMID: 15723365.
      View in: PubMed
    57. Roman KS, Kellenberger CJ, Macgowan CK, Coles J, Redington AN, Benson LN, Yoo SJ. How is pulmonary arterial blood flow affected by pulmonary venous obstruction in children? A phase-contrast magnetic resonance study. Pediatr Radiol. 2005 Jun; 35(6):580-6. PMID: 15657791.
      View in: PubMed
    58. Roman KS, Kellenberger CJ, Farooq S, MacGowan CK, Gilday DL, Yoo SJ. Comparative imaging of differential pulmonary blood flow in patients with congenital heart disease: magnetic resonance imaging versus lung perfusion scintigraphy. Pediatr Radiol. 2005 Mar; 35(3):295-301. PMID: 15490145.
      View in: PubMed
    59. Nield LE, Qi XL, Valsangiacomo ER, Macgowan CK, Wright GA, Hornberger LK, Yoo SJ. In vivo MRI measurement of blood oxygen saturation in children with congenital heart disease. Pediatr Radiol. 2005 Feb; 35(2):179-85. PMID: 15490150.
      View in: PubMed
    60. Sack I, McGowan CK, Samani A, Luginbuhl C, Oakden W, Plewes DB. Observation of nonlinear shear wave propagation using magnetic resonance elastography. Magn Reson Med. 2004 Oct; 52(4):842-50. PMID: 15389935.
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    61. Plewes DB, Luginbuhl C, Macgowan CK, Sack I. . An Inductive Method to Measure Mechanical Excitation Spectra for MRI Elastography. Concepts in Magn. Reson. 2004; 21B(1):32-39.
    62. Valsangiacomo ER, Barrea C, Macgowan CK, Smallhorn JF, Coles JG, Yoo SJ. Phase-contrast MR assessment of pulmonary venous blood flow in children with surgically repaired pulmonary veins. Pediatr Radiol. 2003 Sep; 33(9):607-13. PMID: 12861429.
      View in: PubMed
    63. Kang IS, Redington AN, Benson LN, Macgowan C, Valsangiacomo ER, Roman K, Kellenberger CJ, Yoo SJ. Differential regurgitation in branch pulmonary arteries after repair of tetralogy of Fallot: a phase-contrast cine magnetic resonance study. Circulation. 2003 Jun 17; 107(23):2938-43. PMID: 12771012.
      View in: PubMed
    64. Macgowan CK, Henkelman RM, Wood ML. Pulse-wave velocity measured in one heartbeat using MR tagging. Magn Reson Med. 2002 Jul; 48(1):115-21. PMID: 12111938.
      View in: PubMed
    65. Macgowan CK, Wood ML. Fast measurements of the motion and velocity spectrum of blood using MR tagging. Magn Reson Med. 2001 Mar; 45(3):461-9. PMID: 11241705.
      View in: PubMed
    66. Macgowan CK, Wood ML. Motion measurements from individual MR signals using volume localization. J Magn Reson Imaging. 1999 May; 9(5):670-8. PMID: 10331762.
      View in: PubMed
    67. Macgowan CK, Wood ML. Phase-encode reordering to minimize errors caused by motion. Magn Reson Med. 1996 Mar; 35(3):391-8. PMID: 8699952.
      View in: PubMed
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