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Julie Brill

TitleSenior Scientist
InstitutionThe Hospital for Sick Children
DepartmentCell Biology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
ORCID ORCID Icon0000-0002-5925-9901 Additional info
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    Collapse Biography 
    Collapse education and training
    Swarthmore College, Swarthmore, PA, USABA1985Biology
    M.I.T., Cambridge, MA, USA PhD 1993Biology
    Stanford School of Medicine, Stanford, CA, USA Postdoc 2000Developmental Biology
    University of Washington, Seattle, WA, USAPostdoc 2000Zoology
    Collapse awards and honors
    2017Recipient, Excellence in Undergraduate Laboratory Teaching in Life Sciences Award, Faculty of Medicine, University of Toronto
    2015Elected AAAS Fellow, American Association for the Advancement of Science (AAAS)
    1997 - 2000Special Fellowship , Leukemia & Lymphoma Society
    1996 - 1997Katharine McCormick Fellowship, Stanford University
    1995 - 1996Helena Henzl-Gabor Women in Science Award, Stanford University
    1994 - 1995Katharine McCormick Travel Fund Award, Stanford University
    1993 - 1996NIH National Research Service Award , National Institutes of Health
    1986 - 1989NSF Graduate Fellowship , National Science Foundation

    Collapse Overview 
    Collapse overview
    Dr. Julie Brill graduated with Distinction in Biology from Swarthmore College. She received her PhD in Biology from M.I.T. As a Postdoctoral Fellow at Stanford School of Medicine and a Visiting Postdoc at University of Washington, she discovered a phosphatidylinositol (PI) 4-kinase (PI4KIIIß, or Fwd) required for cytokinesis in Drosophila melanogaster spermatocytes. This discovery led Dr. Brill to further investigate PI4Ks and PI phosphates (PIPs) in her own lab, where she and her colleagues have uncovered novel roles for PIPs and PIP regulatory enzymes in cytokinesis, sperm tail formation, maintenance of cortical integrity, cell polarization and biogenesis of regulated secretory granules.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Volpatti JR, Al-Maawali A, Smith L, Al-Hashim A, Brill JA, Dowling JJ. The expanding spectrum of neurological disorders of phosphoinositide metabolism. Dis Model Mech. 2019 Aug 13; 12(8). PMID: 31413155.
      View in: PubMed
    2. Cantarutti KC, Burgess J, Brill JA, Dason JS. Type II phosphatidylinositol 4-kinase regulates nerve terminal growth and synaptic vesicle recycling. J Neurogenet. 2018 09; 32(3):230-235. PMID: 30175671.
      View in: PubMed
    3. Gupta A, Fabian L, Brill JA. Phosphatidylinositol 4,5-bisphosphate regulates cilium transition zone maturation in Drosophila melanogaster. J Cell Sci. 2018 08 17; 131(16). PMID: 30054387.
      View in: PubMed
    4. Del Bel LM, Griffiths N, Wilk R, Wei HC, Blagoveshchenskaya A, Burgess J, Polevoy G, Price JV, Mayinger P, Brill JA. The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing Drosophila eye. Development. 2018 05 31; 145(11). PMID: 29752385.
      View in: PubMed
    5. Liu CH, Bollepalli MK, Long SV, Asteriti S, Tan J, Brill JA, Hardie RC. Genetic dissection of the phosphoinositide cycle in Drosophila photoreceptors. J Cell Sci. 2018 04 19; 131(8). PMID: 29567856.
      View in: PubMed
    6. Del Bel LM, Brill JA. Sac1, a lipid phosphatase at the interface of vesicular and nonvesicular transport. Traffic. 2018 05; 19(5):301-318. PMID: 29411923.
      View in: PubMed
    7. Brill JA, Rutter J. Quality control and organelle trafficking: ensuring functional organelles and cells. Mol Biol Cell. 2017 03 15; 28(6):701-702. PMID: 28292912.
      View in: PubMed
    8. Brill JA, Yildirim S, Fabian L. Phosphoinositide signaling in sperm development. Semin Cell Dev Biol. 2016 11; 59:2-9. PMID: 27321976.
      View in: PubMed
    9. Giansanti MG, Vanderleest TE, Jewett CE, Sechi S, Frappaolo A, Fabian L, Robinett CC, Brill JA, Loerke D, Fuller MT, Blankenship JT. Exocyst-Dependent Membrane Addition Is Required for Anaphase Cell Elongation and Cytokinesis in Drosophila. PLoS Genet. 2015 Nov; 11(11):e1005632. PMID: 26528720.
      View in: PubMed
    10. Wen J, Duan H, Bejarano F, Okamura K, Fabian L, Brill JA, Bortolamiol-Becet D, Martin R, Ruby JG, Lai EC. Adaptive regulation of testis gene expression and control of male fertility by the Drosophila hairpin RNA pathway. [Corrected]. Mol Cell. 2015 Jan 08; 57(1):165-78. PMID: 25544562.
      View in: PubMed
    11. Sing A, Tsatskis Y, Fabian L, Hester I, Rosenfeld R, Serricchio M, Yau N, Bietenhader M, Shanbhag R, Jurisicova A, Brill JA, McQuibban GA, McNeill H. The atypical cadherin fat directly regulates mitochondrial function and metabolic state. Cell. 2014 Sep 11; 158(6):1293-1308. PMID: 25215488.
      View in: PubMed
    12. Jovic M, Kean MJ, Dubankova A, Boura E, Gingras AC, Brill JA, Balla T. Endosomal sorting of VAMP3 is regulated by PI4K2A. J Cell Sci. 2014 Sep 01; 127(Pt 17):3745-56. PMID: 25002402.
      View in: PubMed
    13. Tan J, Oh K, Burgess J, Hipfner DR, Brill JA. PI4KIIIa is required for cortical integrity and cell polarity during Drosophila oogenesis. J Cell Sci. 2014 Mar 01; 127(Pt 5):954-66. PMID: 24413170.
      View in: PubMed
    14. Tan J, Brill JA. Cinderella story: PI4P goes from precursor to key signaling molecule. Crit Rev Biochem Mol Biol. 2014 Jan-Feb; 49(1):33-58. PMID: 24219382.
      View in: PubMed
    15. Murray MJ, Ng MM, Fraval H, Tan J, Liu W, Smallhorn M, Brill JA, Field SJ, Saint R. Regulation of Drosophila mesoderm migration by phosphoinositides and the PH domain of the Rho GTP exchange factor Pebble. Dev Biol. 2012 Dec 01; 372(1):17-27. PMID: 23000359.
      View in: PubMed
    16. Hernández G, Han H, Gandin V, Fabian L, Ferreira T, Zuberek J, Sonenberg N, Brill JA, Lasko P. Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila. Development. 2012 Sep; 139(17):3211-20. PMID: 22833128.
      View in: PubMed
    17. Burgess J, Del Bel LM, Ma CI, Barylko B, Polevoy G, Rollins J, Albanesi JP, Krämer H, Brill JA. Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila. Development. 2012 Aug; 139(16):3040-50. PMID: 22791894.
      View in: PubMed
    18. Brill JA, Wolfner MF. Overview: Special issue on Drosophila spermatogenesis. Spermatogenesis. 2012 Jul 01; 2(3):127-128. PMID: 23087831.
      View in: PubMed
    19. Fabian L, Brill JA. Drosophila spermiogenesis: Big things come from little packages. Spermatogenesis. 2012 Jul 01; 2(3):197-212. PMID: 23087837.
      View in: PubMed
    20. Jovic M, Kean MJ, Szentpetery Z, Polevoy G, Gingras AC, Brill JA, Balla T. Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, ß-glucocerebrosidase. Mol Biol Cell. 2012 Apr; 23(8):1533-45. PMID: 22337770.
      View in: PubMed
    21. Brill JA, Wong R, Wilde A. Phosphoinositide function in cytokinesis. Curr Biol. 2011 Nov 22; 21(22):R930-4. PMID: 22115464.
      View in: PubMed
    22. Burgess J, Jauregui M, Tan J, Rollins J, Lallet S, Leventis PA, Boulianne GL, Chang HC, Le Borgne R, Krämer H, Brill JA. AP-1 and clathrin are essential for secretory granule biogenesis in Drosophila. Mol Biol Cell. 2011 Jun 15; 22(12):2094-105. PMID: 21490149.
      View in: PubMed
    23. Zhou X, Fabian L, Bayraktar JL, Ding HM, Brill JA, Chang HC. Auxilin is required for formation of Golgi-derived clathrin-coated vesicles during Drosophila spermatogenesis. Development. 2011 Mar; 138(6):1111-20. PMID: 21343365.
      View in: PubMed
    24. Szul T, Burgess J, Jeon M, Zinn K, Marques G, Brill JA, Sztul E. The Garz Sec7 domain guanine nucleotide exchange factor for Arf regulates salivary gland development in Drosophila. Cell Logist. 2011 Mar; 1(2):69-76. PMID: 21686256.
      View in: PubMed
    25. Goldbach P, Wong R, Beise N, Sarpal R, Trimble WS, Brill JA. Stabilization of the actomyosin ring enables spermatocyte cytokinesis in Drosophila. Mol Biol Cell. 2010 May 01; 21(9):1482-93. PMID: 20237160.
      View in: PubMed
    26. Fabian L, Wei HC, Rollins J, Noguchi T, Blankenship JT, Bellamkonda K, Polevoy G, Gervais L, Guichet A, Fuller MT, Brill JA. Phosphatidylinositol 4,5-bisphosphate directs spermatid cell polarity and exocyst localization in Drosophila. Mol Biol Cell. 2010 May 01; 21(9):1546-55. PMID: 20237161.
      View in: PubMed
    27. Polevoy G, Wei HC, Wong R, Szentpetery Z, Kim YJ, Goldbach P, Steinbach SK, Balla T, Brill JA. Dual roles for the Drosophila PI 4-kinase four wheel drive in localizing Rab11 during cytokinesis. J Cell Biol. 2009 Dec 14; 187(6):847-58. PMID: 19995935.
      View in: PubMed
    28. Wei HC, Rollins J, Fabian L, Hayes M, Polevoy G, Bazinet C, Brill JA. Depletion of plasma membrane PtdIns(4,5)P2 reveals essential roles for phosphoinositides in flagellar biogenesis. J Cell Sci. 2008 Apr 01; 121(Pt 7):1076-84. PMID: 18334551.
      View in: PubMed
    29. Wong R, Fabian L, Forer A, Brill JA. Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis. BMC Cell Biol. 2007 May 17; 8:15. PMID: 17509155.
      View in: PubMed
    30. Parsons AB, Lopez A, Givoni IE, Williams DE, Gray CA, Porter J, Chua G, Sopko R, Brost RL, Ho CH, Wang J, Ketela T, Brenner C, Brill JA, Fernandez GE, Lorenz TC, Payne GS, Ishihara S, Ohya Y, Andrews B, Hughes TR, Frey BJ, Graham TR, Andersen RJ, Boone C. Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell. 2006 Aug 11; 126(3):611-25. PMID: 16901791.
      View in: PubMed
    31. Jin Z, Homola EM, Goldbach P, Choi Y, Brill JA, Campbell SD. Drosophila Myt1 is a Cdk1 inhibitory kinase that regulates multiple aspects of cell cycle behavior during gametogenesis. Development. 2005 Sep; 132(18):4075-85. PMID: 16107480.
      View in: PubMed
    32. Wong R, Hadjiyanni I, Wei HC, Polevoy G, McBride R, Sem KP, Brill JA. PIP2 hydrolysis and calcium release are required for cytokinesis in Drosophila spermatocytes. Curr Biol. 2005 Aug 09; 15(15):1401-6. PMID: 16085493.
      View in: PubMed
    33. Saul D, Fabian L, Forer A, Brill JA. Continuous phosphatidylinositol metabolism is required for cleavage of crane fly spermatocytes. J Cell Sci. 2004 Aug 01; 117(Pt 17):3887-96. PMID: 15265984.
      View in: PubMed
    34. Wei HC, Sanny J, Shu H, Baillie DL, Brill JA, Price JV, Harden N. The Sac1 lipid phosphatase regulates cell shape change and the JNK cascade during dorsal closure in Drosophila. Curr Biol. 2003 Oct 28; 13(21):1882-7. PMID: 14588244.
      View in: PubMed
    35. Xu H, Brill JA, Hsien J, McBride R, Boulianne GL, Trimble WS. Syntaxin 5 is required for cytokinesis and spermatid differentiation in Drosophila. Dev Biol. 2002 Nov 15; 251(2):294-306. PMID: 12435359.
      View in: PubMed
    36. Brill JA, Hime GR, Scharer-Schuksz M, Fuller MT. A phospholipid kinase regulates actin organization and intercellular bridge formation during germline cytokinesis. Development. 2000 Sep; 127(17):3855-64. PMID: 10934029.
      View in: PubMed
    37. Molina I, Baars S, Brill JA, Hales KG, Fuller MT, Ripoll P. A chromatin-associated kinesin-related protein required for normal mitotic chromosome segregation in Drosophila. J Cell Biol. 1997 Dec 15; 139(6):1361-71. PMID: 9396743.
      View in: PubMed
    38. Hime GR, Brill JA, Fuller MT. Assembly of ring canals in the male germ line from structural components of the contractile ring. J Cell Sci. 1996 Dec; 109 ( Pt 12):2779-88. PMID: 9013326.
      View in: PubMed
    39. Hatakeyama M, Brill JA, Fink GR, Weinberg RA. Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein. Genes Dev. 1994 Aug 01; 8(15):1759-71. PMID: 7958855.
      View in: PubMed
    40. Brill JA, Elion EA, Fink GR. A role for autophosphorylation revealed by activated alleles of FUS3, the yeast MAP kinase homolog. Mol Biol Cell. 1994 Mar; 5(3):297-312. PMID: 8049522.
      View in: PubMed
    41. Elion EA, Brill JA, Fink GR. FUS3 represses CLN1 and CLN2 and in concert with KSS1 promotes signal transduction. Proc Natl Acad Sci U S A. 1991 Nov 01; 88(21):9392-6. PMID: 1946350.
      View in: PubMed
    42. Elion EA, Brill JA, Fink GR. Functional redundancy in the yeast cell cycle: FUS3 and KSS1 have both overlapping and unique functions. Cold Spring Harb Symp Quant Biol. 1991; 56:41-9. PMID: 1819502.
      View in: PubMed
    43. Berlin V, Brill JA, Trueheart J, Boeke JD, Fink GR. Genetic screens and selections for cell and nuclear fusion mutants. Methods Enzymol. 1991; 194:774-92. PMID: 2005824.
      View in: PubMed
    44. Brill JA, Quinlan-Walshe C, Gottesman S. Fine-structure mapping and identification of two regulators of capsule synthesis in Escherichia coli K-12. J Bacteriol. 1988 Jun; 170(6):2599-611. PMID: 2836365.
      View in: PubMed
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