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Meredith Irwin

TitleStaff Physician
InstitutionThe Hospital for Sick Children
DepartmentHaematology/Oncology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Morgenstern DA, Bagatell R, Cohn SL, Hogarty MD, Maris JM, Moreno L, Park JR, Pearson AD, Schleiermacher G, Valteau-Couanet D, London WB, Irwin MS. The challenge of defining "ultra-high-risk" neuroblastoma. Pediatr Blood Cancer. 2018 Nov 26; e27556. PMID: 30479064.
      View in: PubMed
    2. Alexander N, Marrano P, Thorner P, Naranjo A, Van Ryn C, Martinez D, Batra V, Zhang L, Irwin MS, Baruchel S. Prevalence and Clinical Correlations of Somatostatin Receptor-2 (SSTR2) Expression in Neuroblastoma. J Pediatr Hematol Oncol. 2018 Oct 16. PMID: 30334904.
      View in: PubMed
    3. Depuydt P, Boeva V, Hocking TD, Cannoodt R, Ambros IM, Ambros PF, Asgharzadeh S, Attiyeh EF, Combaret V, Defferrari R, Fischer M, Hero B, Hogarty MD, Irwin MS, Koster J, Kreissman S, Ladenstein R, Lapouble E, Laureys G, London WB, Mazzocco K, Nakagawara A, Noguera R, Ohira M, Park JR, Pötschger U, Theissen J, Tonini GP, Valteau-Couanet D, Varesio L, Versteeg R, Speleman F, Maris JM, Schleiermacher G, De Preter K. Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients. J Natl Cancer Inst. 2018 Oct 01; 110(10):1084-1093. PMID: 29514301.
      View in: PubMed
    4. Schechter T, Perez-Albuerne E, Lin TF, Irwin MS, Essa M, Desai AV, Frangoul H, Yanik G, Dupuis LL, Jacobsohn D, Kletzel M, Ranalli M, Soni S, Seif AE, Grupp S, Dvorak CC. Veno-occlusive disease after high-dose busulfan-melphalan in neuroblastoma. Bone Marrow Transplant. 2018 Sep 04. PMID: 30181580.
      View in: PubMed
    5. Goudie C, Cullinan N, Villani A, Mathews N, van Engelen K, Malkin D, Irwin MS, Foulkes WD. Retrospective evaluation of a decision-support algorithm (MIPOGG) for genetic referrals for children with neuroblastic tumors. Pediatr Blood Cancer. 2018 Dec; 65(12):e27390. PMID: 30117275.
      View in: PubMed
    6. Fahy AS, Roberts A, Nasr A, Irwin MS, Gerstle JT. Long term outcomes after concurrent ipsilateral nephrectomy versus kidney-sparing surgery for high-risk, intraabdominal neuroblastoma. J Pediatr Surg. 2018 Jul 06. PMID: 30029845.
      View in: PubMed
    7. Johnston DL, Murray S, Irwin MS, Doyle J, Schechter T. Autologous stem cell transplantation for refractory opsoclonus myoclonus ataxia syndrome. Pediatr Blood Cancer. 2018 Aug; 65(8):e27110. PMID: 29693780.
      View in: PubMed
    8. Pinto N, DuBois SG, Marachelian A, Diede SJ, Taraseviciute A, Glade Bender JL, Tsao-Wei D, Groshen SG, Reid JM, Haas-Kogan DA, Reynolds CP, Kang MH, Irwin MS, Macy ME, Villablanca JG, Matthay KK, Park JR. Phase I study of vorinostat in combination with isotretinoin in patients with refractory/recurrent neuroblastoma: A new approaches to Neuroblastoma Therapy (NANT) trial. Pediatr Blood Cancer. 2018 Jul; 65(7):e27023. PMID: 29603591.
      View in: PubMed
    9. Alexander N, Sullivan K, Shaikh F, Irwin MS. Characteristics and management of ganglioneuroma and ganglioneuroblastoma-intermixed in children and adolescents. Pediatr Blood Cancer. 2018 May; 65(5):e26964. PMID: 29369484.
      View in: PubMed
    10. Alshareef A, Irwin MS, Gupta N, Zhang HF, Haque M, Findlay SD, Seong BKA, Lai J, Rayis M, Al-Dandan S, Lai R. The absence of a novel intron 19-retaining ALK transcript (ALK-I19) and MYCN amplification correlates with an excellent clinical outcome in neuroblastoma patients. Oncotarget. 2018 Feb 13; 9(12):10698-10713. PMID: 29535836.
      View in: PubMed
    11. Campbell BB, Light N, Fabrizio D, Zatzman M, Fuligni F, de Borja R, Davidson S, Edwards M, Elvin JA, Hodel KP, Zahurancik WJ, Suo Z, Lipman T, Wimmer K, Kratz CP, Bowers DC, Laetsch TW, Dunn GP, Johanns TM, Grimmer MR, Smirnov IV, Larouche V, Samuel D, Bronsema A, Osborn M, Stearns D, Raman P, Cole KA, Storm PB, Yalon M, Opocher E, Mason G, Thomas GA, Sabel M, George B, Ziegler DS, Lindhorst S, Issai VM, Constantini S, Toledano H, Elhasid R, Farah R, Dvir R, Dirks P, Huang A, Galati MA, Chung J, Ramaswamy V, Irwin MS, Aronson M, Durno C, Taylor MD, Rechavi G, Maris JM, Bouffet E, Hawkins C, Costello JF, Meyn MS, Pursell ZF, Malkin D, Tabori U, Shlien A. Comprehensive Analysis of Hypermutation in Human Cancer. Cell. 2017 Nov 16; 171(5):1042-1056.e10. PMID: 29056344.
      View in: PubMed
    12. Campbell K, Gastier-Foster JM, Mann M, Naranjo AH, Van Ryn C, Bagatell R, Matthay KK, London WB, Irwin MS, Shimada H, Granger MM, Hogarty MD, Park JR, DuBois SG. Association of MYCN copy number with clinical features, tumor biology, and outcomes in neuroblastoma: A report from the Children's Oncology Group. Cancer. 2017 Nov 01; 123(21):4224-4235. PMID: 28696504.
      View in: PubMed
    13. Allen CE, Laetsch TW, Mody R, Irwin MS, Lim MS, Adamson PC, Seibel NL, Parsons DW, Cho YJ, Janeway K. Target and Agent Prioritization for the Children's Oncology Group-National Cancer Institute Pediatric MATCH Trial. J Natl Cancer Inst. 2017 05 01; 109(5). PMID: 28376230.
      View in: PubMed
    14. Seibel NL, Janeway K, Allen CE, Chi SN, Cho YJ, Glade Bender JL, Kim A, Laetsch TW, Irwin MS, Takebe N, Tricoli JV, Parsons DW. Pediatric oncology enters an era of precision medicine. Curr Probl Cancer. 2017 May - Jun; 41(3):194-200. PMID: 28343740.
      View in: PubMed
    15. Seong BK, Fathers KE, Hallett R, Yung CK, Stein LD, Mouaaz S, Kee L, Hawkins CE, Irwin MS, Kaplan DR. A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis. Cancer Res. 2017 02 01; 77(3):696-706. PMID: 27899382.
      View in: PubMed
    16. Samuel N, Wilson G, Lemire M, Id Said B, Lou Y, Li W, Merino D, Novokmet A, Tran J, Nichols KE, Finlay JL, Choufani S, Remke M, Ramaswamy V, Cavalli FMG, Elser C, Meister L, Taylor MD, Tabori U, Irwin M, Weksberg R, Wasserman JD, Paterson AD, Hansford JR, Achatz MIW, Hudson TJ, Malkin D. Genome-Wide DNA Methylation Analysis Reveals Epigenetic Dysregulation of MicroRNA-34A in TP53-Associated Cancer Susceptibility. J Clin Oncol. 2016 Oct 20; 34(30):3697-3704. PMID: 27551116.
      View in: PubMed
    17. Angelini P, Irwin MS. Measuring primary tumor response in neuroblastoma: More than using a ruler. Pediatr Blood Cancer. 2017 01; 64(1):11-12. PMID: 27762062.
      View in: PubMed
    18. Waespe N, Van Den Akker M, Klaassen RJ, Lieberman L, Irwin MS, Ali SS, Abdelhaleem M, Zlateska B, Liebman M, Cada M, Schechter T, Dror Y. Response to treatment with azacitidine in children with advanced myelodysplastic syndrome prior to hematopoietic stem cell transplantation. Haematologica. 2016 12; 101(12):1508-1515. PMID: 27540140.
      View in: PubMed
    19. Marrano P, Irwin MS, Thorner PS. Heterogeneity of MYCN amplification in neuroblastoma at diagnosis, treatment, relapse, and metastasis. Genes Chromosomes Cancer. 2017 01; 56(1):28-41. PMID: 27465929.
      View in: PubMed
    20. Hallett RM, Seong AB, Kaplan DR, Irwin MS. Transcript signatures that predict outcome and identify targetable pathways in MYCN-amplified neuroblastoma. Mol Oncol. 2016 11; 10(9):1461-1472. PMID: 27599694.
      View in: PubMed
    21. Morgenstern DA, London WB, Stephens D, Volchenboum SL, Simon T, Nakagawara A, Shimada H, Schleiermacher G, Matthay KK, Cohn SL, Pearson AD, Irwin MS. Prognostic significance of pattern and burden of metastatic disease in patients with stage 4 neuroblastoma: A study from the International Neuroblastoma Risk Group database. Eur J Cancer. 2016 09; 65:1-10. PMID: 27434878.
      View in: PubMed
    22. Owens C, Li BK, Thomas KE, Irwin MS. Surveillance imaging and radiation exposure in the detection of relapsed neuroblastoma. Pediatr Blood Cancer. 2016 10; 63(10):1786-93. PMID: 27304424.
      View in: PubMed
    23. Pinto N, Mayfield JR, Raca G, Applebaum MA, Chlenski A, Sukhanova M, Bagatell R, Irwin MS, Little A, Rawwas J, Gosiengfiao Y, Delattre O, Janoueix-Lerosey I, Lapouble E, Schleiermacher G, Cohn SL. Segmental Chromosomal Aberrations in Localized Neuroblastoma Can be Detected in Formalin-Fixed Paraffin-Embedded Tissue Samples and Are Associated With Recurrence. Pediatr Blood Cancer. 2016 Jun; 63(6):1019-23. PMID: 26864375.
      View in: PubMed
    24. Irwin MS, Park JR. Neuroblastoma: paradigm for precision medicine. Pediatr Clin North Am. 2015 Feb; 62(1):225-56. PMID: 25435121.
      View in: PubMed
    25. Adler E, Alexis C, Ali Z, Allen U, Bartels U, Bick C, Bird-Compton J, Bodkyn C, Boyle R, De Young S, Fleming-Carroll B, Gupta S, Ingram-Martin P, Irwin M, Kirby-Allen M, McLean-Salmon S, Mihelcic P, Richards-Dawson MA, Reece-Mills M, Shaikh F, Sinquee-Brown C, Thame M, Weitzman S, Wharfe G, Blanchette V. Bridging the Distance in the Caribbean: Telemedicine as a means to build capacity for care in paediatric cancer and blood disorders. Stud Health Technol Inform. 2015; 209:1-8. PMID: 25980698.
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    26. Al-Faraj E, Millar BA, Irwin MS, Gupta A. Isolated late CNS relapse in a young adult 10 years after initial treatment for neuroblastoma. J Pediatr Hematol Oncol. 2015 Jan; 37(1):75-7. PMID: 24755834.
      View in: PubMed
    27. Seong BK, Lau J, Adderley T, Kee L, Chaukos D, Pienkowska M, Malkin D, Thorner P, Irwin MS. SATB2 enhances migration and invasion in osteosarcoma by regulating genes involved in cytoskeletal organization. Oncogene. 2015 Jul; 34(27):3582-92. PMID: 25220418.
      View in: PubMed
    28. Podkowa M, Irwin MS. Spy'ing on differentiation in neuroblastoma. Oncotarget. 2014 Aug 15; 5(15):5848-9. PMID: 25109839; PMCID: PMC4171596.
    29. Angelini P, Baruchel S, Marrano P, Irwin MS, Thorner PS. The neuroblastoma and ganglion components of nodular ganglioneuroblastoma are genetically similar: evidence against separate clonal origins. Mod Pathol. 2015 Feb; 28(2):166-76. PMID: 25081755.
      View in: PubMed
    30. Morgenstern DA, Soh SY, Stavropoulos DJ, Bowdin S, Baruchel S, Malkin D, Meyn MS, Irwin MS. Metachronous neuroblastoma in an infant with germline translocation resulting in partial trisomy 2p: a role for ALK? J Pediatr Hematol Oncol. 2014 Apr; 36(3):e193-6. PMID: 24276038.
      View in: PubMed
    31. Morgenstern DA, London WB, Stephens D, Volchenboum SL, Hero B, Di Cataldo A, Nakagawara A, Shimada H, Ambros PF, Matthay KK, Cohn SL, Pearson AD, Irwin MS. Metastatic neuroblastoma confined to distant lymph nodes (stage 4N) predicts outcome in patients with stage 4 disease: A study from the International Neuroblastoma Risk Group Database. J Clin Oncol. 2014 Apr 20; 32(12):1228-35. PMID: 24663047; PMCID: PMC4876342.
    32. Wolter JK, Wolter NE, Blanch A, Partridge T, Cheng L, Morgenstern DA, Podkowa M, Kaplan DR, Irwin MS. Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma. Oncotarget. 2014 Jan 15; 5(1):161-72. PMID: 24389287; PMCID: PMC3960198.
    33. Morgenstern DA, Marzouki M, Bartels U, Irwin MS, Sholler GL, Gammon J, Yankanah R, Wu B, Samson Y, Baruchel S. Phase I study of vinblastine and sirolimus in pediatric patients with recurrent or refractory solid tumors. Pediatr Blood Cancer. 2014 Jan; 61(1):128-33. PMID: 23956145.
      View in: PubMed
    34. Kelleher CM, Smithson L, Nguyen LL, Casadiego G, Nasr A, Irwin MS, Gerstle JT. Clinical outcomes in children with adrenal neuroblastoma undergoing open versus laparoscopic adrenalectomy. J Pediatr Surg. 2013 Aug; 48(8):1727-32. PMID: 23932613.
      View in: PubMed
    35. Gonzalez-Cano L, Hillje AL, Fuertes-Alvarez S, Marques MM, Blanch A, Ian RW, Irwin MS, Schwamborn JC, Marín MC. Regulatory feedback loop between TP73 and TRIM32. Cell Death Dis. 2013 Jul 04; 4:e704. PMID: 23828567; PMCID: PMC3730401.
    36. Morgenstern DA, Baruchel S, Irwin MS. Current and future strategies for relapsed neuroblastoma: challenges on the road to precision therapy. J Pediatr Hematol Oncol. 2013 Jul; 35(5):337-47. PMID: 23703550.
      View in: PubMed
    37. Blanch A, Robinson F, Watson IR, Cheng LS, Irwin MS. Eukaryotic translation elongation factor 1-alpha 1 inhibits p53 and p73 dependent apoptosis and chemotherapy sensitivity. PLoS One. 2013; 8(6):e66436. PMID: 23799104; PMCID: PMC3682968.
    38. Schechter T, Pole JD, Darmawikarta D, Doyle J, Ali M, Egeler M, Gassas A, Irwin MS, Greenberg M, Nathan PC. Late mortality after hematopoietic SCT for a childhood malignancy. Bone Marrow Transplant. 2013 Oct; 48(10):1291-5. PMID: 23665822.
      View in: PubMed
    39. Ashraf K, Shaikh F, Gibson P, Baruchel S, Irwin MS. Treatment with topotecan plus cyclophosphamide in children with first relapse of neuroblastoma. Pediatr Blood Cancer. 2013 Oct; 60(10):1636-41. PMID: 23650219.
      View in: PubMed
    40. Amin R, Moraes TJ, Skitch A, Irwin MS, Meyn S, Witmans M. Diagnostic practices and disease surveillance in Canadian children with congenital central hypoventilation syndrome. Can Respir J. 2013 May-Jun; 20(3):165-70. PMID: 23762885.
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    41. Bunda S, Kang MW, Sybingco SS, Weng J, Favre H, Shin DH, Irwin MS, Loh ML, Ohh M. Inhibition of SRC corrects GM-CSF hypersensitivity that underlies juvenile myelomonocytic leukemia. Cancer Res. 2013 Apr 15; 73(8):2540-50. PMID: 23400592.
      View in: PubMed
    42. Wolter NE, Wolter JK, Enepekides DJ, Irwin MS. Propranolol as a novel adjunctive treatment for head and neck squamous cell carcinoma. J Otolaryngol Head Neck Surg. 2012 Oct; 41(5):334-44. PMID: 23092836.
      View in: PubMed
    43. Owens C, Irwin M. Neuroblastoma: the impact of biology and cooperation leading to personalized treatments. Crit Rev Clin Lab Sci. 2012 May-Jun; 49(3):85-115. PMID: 22646747.
      View in: PubMed
    44. Wang Y, Roche O, Xu C, Moriyama EH, Heir P, Chung J, Roos FC, Chen Y, Finak G, Milosevic M, Wilson BC, Teh BT, Park M, Irwin MS, Ohh M. Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4892-7. PMID: 22411794; PMCID: PMC3323978.
    45. Angelini P, London WB, Cohn SL, Pearson AD, Matthay KK, Monclair T, Ambros PF, Shimada H, Leuschner I, Peuchmaur M, Irwin MS, Baruchel S. Characteristics and outcome of patients with ganglioneuroblastoma, nodular subtype: a report from the INRG project. Eur J Cancer. 2012 May; 48(8):1185-91. PMID: 22137163.
      View in: PubMed
    46. Sen S, Wang H, Nghiem CL, Zhou K, Yau J, Tailor CS, Irwin MS, Dror Y. The ribosome-related protein, SBDS, is critical for normal erythropoiesis. Blood. 2011 Dec 08; 118(24):6407-17. PMID: 21963601.
      View in: PubMed
    47. Chung J, Grant RI, Kaplan DR, Irwin MS. Special AT-rich binding protein-2 (SATB2) differentially affects disease-causing p63 mutant proteins. J Biol Chem. 2011 Nov 25; 286(47):40671-80. PMID: 21965674; PMCID: PMC3220488.
    48. Shuangshoti S, Shuangshoti S, Nuchprayoon I, Kanjanapongkul S, Marrano P, Irwin MS, Thorner PS. Natural course of low risk neuroblastoma. Pediatr Blood Cancer. 2012 May; 58(5):690-4. PMID: 21922650.
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    49. Alexander A, Weber B, Lorenzo A, Keays M, El-Ghazaly T, Bägli DJ, Pippi Salle JL, Irwin M, Farhat W. Hydronephrosis in children with abdominal and pelvic neoplasms: outcome and survival analysis of a single center pediatric oncology series. J Urol. 2011 Oct; 186(4 Suppl):1705-9. PMID: 21855920.
      View in: PubMed
    50. Russell RC, Sufan RI, Zhou B, Heir P, Bunda S, Sybingco SS, Greer SN, Roche O, Heathcote SA, Chow VW, Boba LM, Richmond TD, Hickey MM, Barber DL, Cheresh DA, Simon MC, Irwin MS, Kim WY, Ohh M. Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia. Nat Med. 2011 Jun 19; 17(7):845-53. PMID: 21685897; PMCID: PMC3221316.
    51. French AE, Irwin MS, Navarro OM, Greenberg M, Nathan PC. Long-term hepatic outcomes in survivors of stage 4S and 4 neuroblastoma in infancy. Pediatr Blood Cancer. 2012 Feb; 58(2):283-8. PMID: 21370436.
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    52. Watson IR, Irwin MS, Ohh M. NEDD8 pathways in cancer, Sine Quibus Non. Cancer Cell. 2011 Feb 15; 19(2):168-76. PMID: 21316600.
      View in: PubMed
    53. Grinshtein N, Datti A, Fujitani M, Uehling D, Prakesch M, Isaac M, Irwin MS, Wrana JL, Al-Awar R, Kaplan DR. Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells. Cancer Res. 2011 Feb 15; 71(4):1385-95. PMID: 21303981.
      View in: PubMed
    54. Chung J, Lau J, Cheng LS, Grant RI, Robinson F, Ketela T, Reis PP, Roche O, Kamel-Reid S, Moffat J, Ohh M, Perez-Ordonez B, Kaplan DR, Irwin MS. SATB2 augments ?Np63a in head and neck squamous cell carcinoma. EMBO Rep. 2010 Oct; 11(10):777-83. PMID: 20829881; PMCID: PMC2948183.
    55. Smith KM, Datti A, Fujitani M, Grinshtein N, Zhang L, Morozova O, Blakely KM, Rotenberg SA, Hansford LM, Miller FD, Yeger H, Irwin MS, Moffat J, Marra MA, Baruchel S, Wrana JL, Kaplan DR. Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens. EMBO Mol Med. 2010 Sep; 2(9):371-84. PMID: 20721990; PMCID: PMC3377336.
    56. Chung J, Irwin MS. Targeting the p53-family in cancer and chemosensitivity: triple threat. Curr Drug Targets. 2010 Jun; 11(6):667-81. PMID: 20298155.
      View in: PubMed
    57. Wolter J, Angelini P, Irwin M. p53 family: Therapeutic targets in neuroblastoma. Future Oncol. 2010 Mar; 6(3):429-44. PMID: 20222799.
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    58. Roberts AM, Watson IR, Evans AJ, Foster DA, Irwin MS, Ohh M. Suppression of hypoxia-inducible factor 2alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells. Cancer Res. 2009 Dec 01; 69(23):9056-64. PMID: 19920202; PMCID: PMC2789194.
    59. Molina AR, Ponniah A, Simcock J, Irwin MS, Malata CM. Resource implications of bilateral autologous breast reconstruction--a single centre's seven year experience. J Plast Reconstr Aesthet Surg. 2010 Oct; 63(10):1588-91. PMID: 19913470.
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    60. Watson IR, Li BK, Roche O, Blanch A, Ohh M, Irwin MS. Chemotherapy induces NEDP1-mediated destabilization of MDM2. Oncogene. 2010 Jan 14; 29(2):297-304. PMID: 19784069.
      View in: PubMed
    61. Zhang L, Smith KM, Chong AL, Stempak D, Yeger H, Marrano P, Thorner PS, Irwin MS, Kaplan DR, Baruchel S. In vivo antitumor and antimetastatic activity of sunitinib in preclinical neuroblastoma mouse model. Neoplasia. 2009 May; 11(5):426-35. PMID: 19412427; PMCID: PMC2671855.
    62. Lau LM, Wolter JK, Lau JT, Cheng LS, Smith KM, Hansford LM, Zhang L, Baruchel S, Robinson F, Irwin MS. Cyclooxygenase inhibitors differentially modulate p73 isoforms in neuroblastoma. Oncogene. 2009 May 14; 28(19):2024-33. PMID: 19363520.
      View in: PubMed
    63. Wang Y, Roche O, Yan MS, Finak G, Evans AJ, Metcalf JL, Hast BE, Hanna SC, Wondergem B, Furge KA, Irwin MS, Kim WY, Teh BT, Grinstein S, Park M, Marsden PA, Ohh M. Regulation of endocytosis via the oxygen-sensing pathway. Nat Med. 2009 Mar; 15(3):319-24. PMID: 19252501.
      View in: PubMed
    64. Hansford LM, McKee AE, Zhang L, George RE, Gerstle JT, Thorner PS, Smith KM, Look AT, Yeger H, Miller FD, Irwin MS, Thiele CJ, Kaplan DR. Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell. Cancer Res. 2007 Dec 01; 67(23):11234-43. PMID: 18056449.
      View in: PubMed
    65. Lau LM, Nugent JK, Zhao X, Irwin MS. HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function. Oncogene. 2008 Feb 07; 27(7):997-1003. PMID: 17700533.
      View in: PubMed
    66. Castellino RC, De Bortoli M, Lin LL, Skapura DG, Rajan JA, Adesina AM, Perlaky L, Irwin MS, Kim JY. Overexpressed TP73 induces apoptosis in medulloblastoma. BMC Cancer. 2007 Jul 12; 7:127. PMID: 17626635; PMCID: PMC1955450.
    67. Zhang L, Yeger H, Das B, Irwin MS, Baruchel S. Tissue microenvironment modulates CXCR4 expression and tumor metastasis in neuroblastoma. Neoplasia. 2007 Jan; 9(1):36-46. PMID: 17325742; PMCID: PMC1803034.
    68. Gupta A, Kumar A, Walters S, Chait P, Irwin MS, Gerstle JT. Analysis of needle versus open biopsy for the diagnosis of advanced stage pediatric neuroblastoma. Pediatr Blood Cancer. 2006 Dec; 47(7):875-9. PMID: 16276526.
      View in: PubMed
    69. Evans AJ, Russell RC, Roche O, Burry TN, Fish JE, Chow VW, Kim WY, Saravanan A, Maynard MA, Gervais ML, Sufan RI, Roberts AM, Wilson LA, Betten M, Vandewalle C, Berx G, Marsden PA, Irwin MS, Teh BT, Jewett MA, Ohh M. VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail. Mol Cell Biol. 2007 Jan; 27(1):157-69. PMID: 17060462.
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    70. Lau L, Hansford LM, Cheng LS, Hang M, Baruchel S, Kaplan DR, Irwin MS. Cyclooxygenase inhibitors modulate the p53/HDM2 pathway and enhance chemotherapy-induced apoptosis in neuroblastoma. Oncogene. 2007 Mar 22; 26(13):1920-31. PMID: 16983334.
      View in: PubMed
    71. Watson IR, Blanch A, Lin DC, Ohh M, Irwin MS. Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function. J Biol Chem. 2006 Nov 10; 281(45):34096-103. PMID: 16980297.
      View in: PubMed
    72. Watson IR, Irwin MS. Ubiquitin and ubiquitin-like modifications of the p53 family. Neoplasia. 2006 Aug; 8(8):655-66. PMID: 16925948; PMCID: PMC1601941.
    73. Irwin MS. DeltaNp73: misunderstood protein? Cancer Biol Ther. 2006 Jul; 5(7):804-7. PMID: 16921261.
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    74. Cantos MF, Gerstle JT, Irwin MS, Pappo A, Farley S, Cheang T, Kim PC. Surgical challenges associated with intensive treatment protocols for high-risk neuroblastoma. J Pediatr Surg. 2006 May; 41(5):960-5. PMID: 16677893.
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    75. Antony R, Al-Rawas A, Irwin M. Stridor in a newborn. CMAJ. 2005 Sep 13; 173(6):601-2. PMID: 16157723; PMCID: PMC1197159.
    76. Stickle NH, Cheng LS, Watson IR, Alon N, Malkin D, Irwin MS, Ohh M. Expression of p53 in renal carcinoma cells is independent of pVHL. Mutat Res. 2005 Oct 15; 578(1-2):23-32. PMID: 15998523.
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    77. Irwin MS, Miller FD. p73: regulator in cancer and neural development. Cell Death Differ. 2004 Jul; 11 Suppl 1:S17-22. PMID: 15153941.
      View in: PubMed
    78. Irwin MS. Family feud in chemosensitvity: p73 and mutant p53. Cell Cycle. 2004 Mar; 3(3):319-23. PMID: 14739781.
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    79. Irwin MS, Kondo K, Marin MC, Cheng LS, Hahn WC, Kaelin WG. Chemosensitivity linked to p73 function. Cancer Cell. 2003 Apr; 3(4):403-10. PMID: 12726865.
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    80. Basu S, Totty NF, Irwin MS, Sudol M, Downward J. Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Mol Cell. 2003 Jan; 11(1):11-23. PMID: 12535517.
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    81. Seelan RS, Irwin M, van der Stoop P, Qian C, Kaelin WG, Liu W. The human p73 promoter: characterization and identification of functional E2F binding sites. Neoplasia. 2002 May-Jun; 4(3):195-203. PMID: 11988839; PMCID: PMC1531693.
    82. Irwin MS, Kaelin WG. p53 family update: p73 and p63 develop their own identities. Cell Growth Differ. 2001 Jul; 12(7):337-49. PMID: 11457731.
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    83. Irwin MS, Kaelin WG. Role of the newer p53 family proteins in malignancy. Apoptosis. 2001 Feb-Apr; 6(1-2):17-29. PMID: 11321038.
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    84. Marin MC, Jost CA, Brooks LA, Irwin MS, O'Nions J, Tidy JA, James N, McGregor JM, Harwood CA, Yulug IG, Vousden KH, Allday MJ, Gusterson B, Ikawa S, Hinds PW, Crook T, Kaelin WG. A common polymorphism acts as an intragenic modifier of mutant p53 behaviour. Nat Genet. 2000 May; 25(1):47-54. PMID: 10802655.
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    85. Marin MC, Jost CA, Irwin MS, DeCaprio JA, Caput D, Kaelin WG. Viral oncoproteins discriminate between p53 and the p53 homolog p73. Mol Cell Biol. 1998 Nov; 18(11):6316-24. PMID: 9774648; PMCID: PMC109218.
    86. Irwin MS, Gilbert SE, Terenghi G, Smith RW, Green CJ. Cold intolerance following peripheral nerve injury. Natural history and factors predicting severity of symptoms. J Hand Surg Br. 1997 Jun; 22(3):308-16. PMID: 9222907.
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