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Freda Miller

TitleSenior Scientist
InstitutionThe Hospital for Sick Children
DepartmentNeurosciences & Mental Health
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Carr MJ, Toma JS, Johnston APW, Steadman PE, Yuzwa SA, Mahmud N, Frankland PW, Kaplan DR, Miller FD. Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and Regeneration. Cell Stem Cell. 2019 Feb 07; 24(2):240-256.e9. PMID: 30503141.
      View in: PubMed
    2. Storer MA, Gallagher D, Fatt MP, Simonetta JV, Kaplan DR, Miller FD. Interleukin-6 Regulates Adult Neural Stem Cell Numbers during Normal and Abnormal Post-natal Development. Stem Cell Reports. 2018 05 08; 10(5):1464-1480. PMID: 29628394.
      View in: PubMed
    3. Zahr SK, Yang G, Kazan H, Borrett MJ, Yuzwa SA, Voronova A, Kaplan DR, Miller FD. A Translational Repression Complex in Developing Mammalian Neural Stem Cells that Regulates Neuronal Specification. Neuron. 2018 02 07; 97(3):520-537.e6. PMID: 29395907.
      View in: PubMed
    4. Yuzwa SA, Borrett MJ, Innes BT, Voronova A, Ketela T, Kaplan DR, Bader GD, Miller FD. Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling. Cell Rep. 2017 12 26; 21(13):3970-3986. PMID: 29281841.
      View in: PubMed
    5. Feinberg K, Kolaj A, Wu C, Grinshtein N, Krieger JR, Moran MF, Rubin LL, Miller FD, Kaplan DR. A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria. J Cell Biol. 2017 11 06; 216(11):3655-3675. PMID: 28877995.
      View in: PubMed
    6. Voronova A, Yuzwa SA, Wang BS, Zahr S, Syal C, Wang J, Kaplan DR, Miller FD. Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain. Neuron. 2017 May 03; 94(3):500-516.e9. PMID: 28472653.
      View in: PubMed
    7. Yuzwa SA, Miller FD. Deciphering cell-cell communication in the developing mammalian brain. Neurogenesis (Austin). 2017; 4(1):e1286425. PMID: 28265587.
      View in: PubMed
    8. Yang G, Cancino GI, Zahr SK, Guskjolen A, Voronova A, Gallagher D, Frankland PW, Kaplan DR, Miller FD. A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring. Cell Rep. 2016 10 18; 17(4):1022-1036. PMID: 27760310.
      View in: PubMed
    9. Yuzwa SA, Yang G, Borrett MJ, Clarke G, Cancino GI, Zahr SK, Zandstra PW, Kaplan DR, Miller FD. Proneurogenic Ligands Defined by Modeling Developing Cortex Growth Factor Communication Networks. Neuron. 2016 Sep 07; 91(5):988-1004. PMID: 27545711.
      View in: PubMed
    10. Johnston AP, Yuzwa SA, Carr MJ, Mahmud N, Storer MA, Krause MP, Jones K, Paul S, Kaplan DR, Miller FD. Dedifferentiated Schwann Cell Precursors Secreting Paracrine Factors Are Required for Regeneration of the Mammalian Digit Tip. Cell Stem Cell. 2016 10 06; 19(4):433-448. PMID: 27376984.
      View in: PubMed
    11. Naska S, Yuzwa SA, Johnston AP, Paul S, Smith KM, Paris M, Sefton MV, Datti A, Miller FD, Kaplan DR. Identification of Drugs that Regulate Dermal Stem Cells and Enhance Skin Repair. Stem Cell Reports. 2016 Jan 12; 6(1):74-84. PMID: 26724904.
      View in: PubMed
    12. Fatt M, Hsu K, He L, Wondisford F, Miller FD, Kaplan DR, Wang J. Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation. Stem Cell Reports. 2015 Dec 08; 5(6):988-995. PMID: 26677765.
      View in: PubMed
    13. Dadwal P, Mahmud N, Sinai L, Azimi A, Fatt M, Wondisford FE, Miller FD, Morshead CM. Activating Endogenous Neural Precursor Cells Using Metformin Leads to Neural Repair and Functional Recovery in a Model of Childhood Brain Injury. Stem Cell Reports. 2015 Aug 11; 5(2):166-73. PMID: 26235894.
      View in: PubMed
    14. Cancino GI, Fatt MP, Miller FD, Kaplan DR. Conditional ablation of p63 indicates that it is essential for embryonic development of the central nervous system. Cell Cycle. 2015; 14(20):3270-81. PMID: 26359534.
      View in: PubMed
    15. Gallagher D, Voronova A, Zander MA, Cancino GI, Bramall A, Krause MP, Abad C, Tekin M, Neilsen PM, Callen DF, Scherer SW, Keller GM, Kaplan DR, Walz K, Miller FD. Ankrd11 is a chromatin regulator involved in autism that is essential for neural development. Dev Cell. 2015 Jan 12; 32(1):31-42. PMID: 25556659.
      View in: PubMed
    16. Yang G, Smibert CA, Kaplan DR, Miller FD. An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program. Neuron. 2014 Nov 19; 84(4):723-39. PMID: 25456498.
      View in: PubMed
    17. Zander MA, Cancino GI, Gridley T, Kaplan DR, Miller FD. The Snail transcription factor regulates the numbers of neural precursor cells and newborn neurons throughout mammalian life. PLoS One. 2014; 9(8):e104767. PMID: 25136812.
      View in: PubMed
    18. Krause MP, Dworski S, Feinberg K, Jones K, Johnston AP, Paul S, Paris M, Peles E, Bagli D, Forrest CR, Kaplan DR, Miller FD. Direct genesis of functional rodent and human schwann cells from skin mesenchymal precursors. Stem Cell Reports. 2014 Jul 08; 3(1):85-100. PMID: 25068124.
      View in: PubMed
    19. Zander MA, Burns SE, Yang G, Kaplan DR, Miller FD. Snail coordinately regulates downstream pathways to control multiple aspects of mammalian neural precursor development. J Neurosci. 2014 Apr 09; 34(15):5164-75. PMID: 24719096.
      View in: PubMed
    20. Tsui D, Voronova A, Gallagher D, Kaplan DR, Miller FD, Wang J. CBP regulates the differentiation of interneurons from ventral forebrain neural precursors during murine development. Dev Biol. 2014 Jan 15; 385(2):230-41. PMID: 24247009.
      View in: PubMed
    21. Gallagher D, Norman AA, Woodard CL, Yang G, Gauthier-Fisher A, Fujitani M, Vessey JP, Cancino GI, Sachewsky N, Woltjen K, Fatt MP, Morshead CM, Kaplan DR, Miller FD. Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathway. Cell Stem Cell. 2013 Nov 07; 13(5):564-76. PMID: 24209760.
      View in: PubMed
    22. Cancino GI, Yiu AP, Fatt MP, Dugani CB, Flores ER, Frankland PW, Josselyn SA, Miller FD, Kaplan DR. p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior. J Neurosci. 2013 Jul 31; 33(31):12569-85. PMID: 23904595.
      View in: PubMed
    23. Johnston AP, Naska S, Jones K, Jinno H, Kaplan DR, Miller FD. Sox2-mediated regulation of adult neural crest precursors and skin repair. Stem Cell Reports. 2013; 1(1):38-45. PMID: 24052940.
      View in: PubMed
    24. Tsui D, Vessey JP, Tomita H, Kaplan DR, Miller FD. FoxP2 regulates neurogenesis during embryonic cortical development. J Neurosci. 2013 Jan 02; 33(1):244-58. PMID: 23283338.
      View in: PubMed
    25. Vessey JP, Amadei G, Burns SE, Kiebler MA, Kaplan DR, Miller FD. An asymmetrically localized Staufen2-dependent RNA complex regulates maintenance of mammalian neural stem cells. Cell Stem Cell. 2012 Oct 05; 11(4):517-28. PMID: 22902294.
      View in: PubMed
    26. Wang J, Gallagher D, DeVito LM, Cancino GI, Tsui D, He L, Keller GM, Frankland PW, Kaplan DR, Miller FD. Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell. 2012 Jul 06; 11(1):23-35. PMID: 22770240.
      View in: PubMed
    27. Miller FD, Kaplan DR. Mobilizing endogenous stem cells for repair and regeneration: are we there yet? Cell Stem Cell. 2012 Jun 14; 10(6):650-652. PMID: 22704501.
      View in: PubMed
    28. Cancino GI, Miller FD, Kaplan DR. p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease. Neurobiol Aging. 2013 Feb; 34(2):387-99. PMID: 22592019.
      View in: PubMed
    29. Raj B, O'Hanlon D, Vessey JP, Pan Q, Ray D, Buckley NJ, Miller FD, Blencowe BJ. Cross-regulation between an alternative splicing activator and a transcription repressor controls neurogenesis. Mol Cell. 2011 Sep 02; 43(5):843-50. PMID: 21884984.
      View in: PubMed
    30. Antony JM, Paquin A, Nutt SL, Kaplan DR, Miller FD. Endogenous microglia regulate development of embryonic cortical precursor cells. J Neurosci Res. 2011 Mar; 89(3):286-98. PMID: 21259316.
      View in: PubMed
    31. Fujitani M, Cancino GI, Dugani CB, Weaver IC, Gauthier-Fisher A, Paquin A, Mak TW, Wojtowicz MJ, Miller FD, Kaplan DR. TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors. Curr Biol. 2010 Nov 23; 20(22):2058-65. PMID: 21074438.
      View in: PubMed
    32. Jinno H, Morozova O, Jones KL, Biernaskie JA, Paris M, Hosokawa R, Rudnicki MA, Chai Y, Rossi F, Marra MA, Miller FD. Convergent genesis of an adult neural crest-like dermal stem cell from distinct developmental origins. Stem Cells. 2010 Nov; 28(11):2027-40. PMID: 20848654.
      View in: PubMed
    33. Dugani CB, Paquin A, Kaplan DR, Miller FD. Coffin-Lowry syndrome: a role for RSK2 in mammalian neurogenesis. Dev Biol. 2010 Nov 15; 347(2):348-59. PMID: 20832397.
      View in: PubMed
    34. Smith KM, Datti A, Fujitani M, Grinshtein N, Zhang L, Morozova O, Blakely KM, Rotenberg SA, Hansford LM, Miller FD, Yeger H, Irwin MS, Moffat J, Marra MA, Baruchel S, Wrana JL, Kaplan DR. Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens. EMBO Mol Med. 2010 Sep; 2(9):371-84. PMID: 20721990.
      View in: PubMed
    35. Yu LM, Miller FD, Shoichet MS. The use of immobilized neurotrophins to support neuron survival and guide nerve fiber growth in compartmentalized chambers. Biomaterials. 2010 Sep; 31(27):6987-99. PMID: 20579725.
      View in: PubMed
    36. Naska S, Lin DC, Miller FD, Kaplan DR. p75NTR is an obligate signaling receptor required for cues that cause sympathetic neuron growth cone collapse. Mol Cell Neurosci. 2010 Oct; 45(2):108-20. PMID: 20584617.
      View in: PubMed
    37. Wang J, Weaver IC, Gauthier-Fisher A, Wang H, He L, Yeomans J, Wondisford F, Kaplan DR, Miller FD. CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain. Dev Cell. 2010 Jan 19; 18(1):114-25. PMID: 20152182.
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    38. Biernaskie J, Paris M, Morozova O, Fagan BM, Marra M, Pevny L, Miller FD. SKPs derive from hair follicle precursors and exhibit properties of adult dermal stem cells. Cell Stem Cell. 2009 Dec 04; 5(6):610-23. PMID: 19951689.
      View in: PubMed
    39. Lavoie JF, Biernaskie JA, Chen Y, Bagli D, Alman B, Kaplan DR, Miller FD. Skin-derived precursors differentiate into skeletogenic cell types and contribute to bone repair. Stem Cells Dev. 2009 Jul-Aug; 18(6):893-906. PMID: 18834279.
      View in: PubMed
    40. Miller FD, Gauthier-Fisher A. Home at last: neural stem cell niches defined. Cell Stem Cell. 2009 Jun 05; 4(6):507-10. PMID: 19497279.
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    41. Dugani CB, Paquin A, Fujitani M, Kaplan DR, Miller FD. p63 antagonizes p53 to promote the survival of embryonic neural precursor cells. J Neurosci. 2009 May 20; 29(20):6710-21. PMID: 19458240.
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    42. Gauthier-Fisher A, Lin DC, Greeve M, Kaplan DR, Rottapel R, Miller FD. Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells. Nat Neurosci. 2009 Jun; 12(6):735-44. PMID: 19448628.
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    43. Paquin A, Hordo C, Kaplan DR, Miller FD. Costello syndrome H-Ras alleles regulate cortical development. Dev Biol. 2009 Jun 15; 330(2):440-51. PMID: 19371735.
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    44. Frankland PW, Miller FD. Regenerating your senses: multiple roles for neurogenesis in the adult brain. Nat Neurosci. 2008 Oct; 11(10):1124-6. PMID: 18818592.
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    45. Singh KK, Park KJ, Hong EJ, Kramer BM, Greenberg ME, Kaplan DR, Miller FD. Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration. Nat Neurosci. 2008 Jun; 11(6):649-58. PMID: 18382462.
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    46. Fernandes KJ, Toma JG, Miller FD. Multipotent skin-derived precursors: adult neural crest-related precursors with therapeutic potential. Philos Trans R Soc Lond B Biol Sci. 2008 Jan 12; 363(1489):185-98. PMID: 17282990.
      View in: PubMed
    47. Hansford LM, McKee AE, Zhang L, George RE, Gerstle JT, Thorner PS, Smith KM, Look AT, Yeger H, Miller FD, Irwin MS, Thiele CJ, Kaplan DR. Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell. Cancer Res. 2007 Dec 01; 67(23):11234-43. PMID: 18056449.
      View in: PubMed
    48. Bartkowska K, Paquin A, Gauthier AS, Kaplan DR, Miller FD. Trk signaling regulates neural precursor cell proliferation and differentiation during cortical development. Development. 2007 Dec; 134(24):4369-80. PMID: 18003743.
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    49. Biernaskie J, Sparling JS, Liu J, Shannon CP, Plemel JR, Xie Y, Miller FD, Tetzlaff W. Skin-derived precursors generate myelinating Schwann cells that promote remyelination and functional recovery after contusion spinal cord injury. J Neurosci. 2007 Sep 05; 27(36):9545-59. PMID: 17804616.
      View in: PubMed
    50. Miller FD. Riding the waves: neural and nonneural origins for mesenchymal stem cells. Cell Stem Cell. 2007 Aug 16; 1(2):129-30. PMID: 18371342.
      View in: PubMed
    51. Kaplan DR, Miller FD. Developing with BDNF: a moving experience. Neuron. 2007 Jul 05; 55(1):1-2. PMID: 17610810.
      View in: PubMed
    52. Miller FD, Gauthier AS. Timing is everything: making neurons versus glia in the developing cortex. Neuron. 2007 May 03; 54(3):357-69. PMID: 17481390.
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    53. Gauthier AS, Furstoss O, Araki T, Chan R, Neel BG, Kaplan DR, Miller FD. Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome. Neuron. 2007 Apr 19; 54(2):245-62. PMID: 17442246.
      View in: PubMed
    54. Miller FD, Kaplan DR. To die or not to die: neurons and p63. Cell Cycle. 2007 Feb 01; 6(3):312-7. PMID: 17264677.
      View in: PubMed
    55. Naska S, Park KJ, Hannigan GE, Dedhar S, Miller FD, Kaplan DR. An essential role for the integrin-linked kinase-glycogen synthase kinase-3 beta pathway during dendrite initiation and growth. J Neurosci. 2006 Dec 20; 26(51):13344-56. PMID: 17182785.
      View in: PubMed
    56. Lin DC, Quevedo C, Brewer NE, Bell A, Testa JR, Grimes ML, Miller FD, Kaplan DR. APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction. Mol Cell Biol. 2006 Dec; 26(23):8928-41. PMID: 17000777.
      View in: PubMed
    57. Hibbert AP, Kramer BM, Miller FD, Kaplan DR. The localization, trafficking and retrograde transport of BDNF bound to p75NTR in sympathetic neurons. Mol Cell Neurosci. 2006 Aug; 32(4):387-402. PMID: 16843677.
      View in: PubMed
    58. McKenzie IA, Biernaskie J, Toma JG, Midha R, Miller FD. Skin-derived precursors generate myelinating Schwann cells for the injured and dysmyelinated nervous system. J Neurosci. 2006 Jun 14; 26(24):6651-60. PMID: 16775154.
      View in: PubMed
    59. Jacobs WB, Kaplan DR, Miller FD. The p53 family in nervous system development and disease. J Neurochem. 2006 Jun; 97(6):1571-84. PMID: 16805769.
      View in: PubMed
    60. Fernandes KJ, Kobayashi NR, Gallagher CJ, Barnabé-Heider F, Aumont A, Kaplan DR, Miller FD. Analysis of the neurogenic potential of multipotent skin-derived precursors. Exp Neurol. 2006 Sep; 201(1):32-48. PMID: 16678161.
      View in: PubMed
    61. Kaplan DR, Miller FD. When a motor goes bad: a kinesin regulates neuronal survival. Cell. 2006 Apr 21; 125(2):224-6. PMID: 16630809.
      View in: PubMed
    62. Biernaskie JA, McKenzie IA, Toma JG, Miller FD. Isolation of skin-derived precursors (SKPs) and differentiation and enrichment of their Schwann cell progeny. Nat Protoc. 2006; 1(6):2803-12. PMID: 17406538.
      View in: PubMed
    63. Jacobs WB, Govoni G, Ho D, Atwal JK, Barnabe-Heider F, Keyes WM, Mills AA, Miller FD, Kaplan DR. p63 is an essential proapoptotic protein during neural development. Neuron. 2005 Dec 08; 48(5):743-56. PMID: 16337913.
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    64. Paquin A, Barnabé-Heider F, Kageyama R, Miller FD. CCAAT/enhancer-binding protein phosphorylation biases cortical precursors to generate neurons rather than astrocytes in vivo. J Neurosci. 2005 Nov 16; 25(46):10747-58. PMID: 16291948.
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    65. Barnabé-Heider F, Wasylnka JA, Fernandes KJ, Porsche C, Sendtner M, Kaplan DR, Miller FD. Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1. Neuron. 2005 Oct 20; 48(2):253-65. PMID: 16242406.
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    66. Nadeau S, Hein P, Fernandes KJ, Peterson AC, Miller FD. A transcriptional role for C/EBP beta in the neuronal response to axonal injury. Mol Cell Neurosci. 2005 Aug; 29(4):525-35. PMID: 15936952.
      View in: PubMed
    67. Lavoie JF, Lesauteur L, Kohn J, Wong J, Furtoss O, Thiele CJ, Miller FD, Kaplan DR. TrkA induces apoptosis of neuroblastoma cells and does so via a p53-dependent mechanism. J Biol Chem. 2005 Aug 12; 280(32):29199-207. PMID: 15961390.
      View in: PubMed
    68. Toma JG, McKenzie IA, Bagli D, Miller FD. Isolation and characterization of multipotent skin-derived precursors from human skin. Stem Cells. 2005 Jun-Jul; 23(6):727-37. PMID: 15917469.
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    69. Singh KK, Miller FD. Activity regulates positive and negative neurotrophin-derived signals to determine axon competition. Neuron. 2005 Mar 24; 45(6):837-45. PMID: 15797546.
      View in: PubMed
    70. Fernandes KJ, McKenzie IA, Mill P, Smith KM, Akhavan M, Barnabé-Heider F, Biernaskie J, Junek A, Kobayashi NR, Toma JG, Kaplan DR, Labosky PA, Rafuse V, Hui CC, Miller FD. A dermal niche for multipotent adult skin-derived precursor cells. Nat Cell Biol. 2004 Nov; 6(11):1082-93. PMID: 15517002.
      View in: PubMed
    71. Walsh GS, Orike N, Kaplan DR, Miller FD. The invulnerability of adult neurons: a critical role for p73. J Neurosci. 2004 Oct 27; 24(43):9638-47. PMID: 15509751.
      View in: PubMed
    72. Lee AF, Ho DK, Zanassi P, Walsh GS, Kaplan DR, Miller FD. Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms. J Neurosci. 2004 Oct 13; 24(41):9174-84. PMID: 15483136.
      View in: PubMed
    73. Jacobs WB, Walsh GS, Miller FD. Neuronal survival and p73/p63/p53: a family affair. Neuroscientist. 2004 Oct; 10(5):443-55. PMID: 15359011.
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    74. Atwal JK, Singh KK, Tessier-Lavigne M, Miller FD, Kaplan DR. Semaphorin 3F antagonizes neurotrophin-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase signaling: a mechanism for growth cone collapse. J Neurosci. 2003 Aug 20; 23(20):7602-9. PMID: 12930799.
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    75. Miller FD, Kaplan DR. Signaling mechanisms underlying dendrite formation. Curr Opin Neurobiol. 2003 Jun; 13(3):391-8. PMID: 12850225.
      View in: PubMed
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