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Andrew Willan

TitleClinical Trials Methodologist
InstitutionThe Hospital for Sick Children
DepartmentClinical Research Services
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Freedman SB, Williamson-Urquhart S, Farion KJ, Gouin S, Willan AR, Poonai N, Hurley K, Sherman PM, Finkelstein Y, Lee BE, Pang XL, Chui L, Schnadower D, Xie J, Gorelick M, Schuh S. Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis. N Engl J Med. 2018 11 22; 379(21):2015-2026. PMID: 30462939.
      View in: PubMed
    2. Freedman SB, Soofi SB, Willan AR, Williamson-Urquhart S, Ali N, Xie J, Dawoud F, Bhutta ZA. Oral Ondansetron Administration to Nondehydrated Children With Diarrhea and Associated Vomiting in Emergency Departments in Pakistan: A Randomized Controlled Trial. Ann Emerg Med. 2018 Nov 01. PMID: 30392735.
      View in: PubMed
    3. Hutton EK, Hannah ME, Willan AR, Ross S, Allen AC, Armson BA, Gafni A, Joseph KS, Mangoff K, Ohlsson A, Sanchez JJ, Asztalos EV, Barrett J. Urinary stress incontinence and other maternal outcomes 2 years after caesarean or vaginal birth for twin pregnancy: a multicentre randomised trial. BJOG. 2018 Dec; 125(13):1682-1690. PMID: 30007113.
      View in: PubMed
    4. Roth DE, Morris SK, Zlotkin S, Gernand AD, Ahmed T, Shanta SS, Papp E, Korsiak J, Shi J, Islam MM, Jahan I, Keya FK, Willan AR, Weksberg R, Mohsin M, Rahman QS, Shah PS, Murphy KE, Stimec J, Pell LG, Qamar H, Al Mahmud A. Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth. N Engl J Med. 2018 Aug 09; 379(6):535-546. PMID: 30089075.
      View in: PubMed
    5. Mei-Dan E, Dougan C, Melamed N, Asztalos EV, Aviram A, Willan AR, Barrett JFR. Planned cesarean or vaginal delivery for women in spontaneous labor with a twin pregnancy: A secondary analysis of the Twin Birth Study. Birth. 2018 Aug 02. PMID: 30073688.
      View in: PubMed
    6. Mahant S, Wahi G, Giglia L, Pound C, Kanani R, Bayliss A, Roy M, Sakran M, Kozlowski N, Breen-Reid K, Lavigne M, Premji L, Moretti ME, Willan AR, Schuh S, Parkin PC. Intermittent versus continuous oxygen saturation monitoring for infants hospitalised with bronchiolitis: study protocol for a pragmatic randomised controlled trial. BMJ Open. 2018 04 20; 8(4):e022707. PMID: 29678995.
      View in: PubMed
    7. Parshuram CS, Dryden-Palmer K, Farrell C, Gottesman R, Gray M, Hutchison JS, Helfaer M, Hunt EA, Joffe AR, Lacroix J, Moga MA, Nadkarni V, Ninis N, Parkin PC, Wensley D, Willan AR, Tomlinson GA. Effect of a Pediatric Early Warning System on All-Cause Mortality in Hospitalized Pediatric Patients: The EPOCH Randomized Clinical Trial. JAMA. 2018 03 13; 319(10):1002-1012. PMID: 29486493.
      View in: PubMed
    8. Stevens B, Yamada J, Campbell-Yeo M, Gibbins S, Harrison D, Dionne K, Taddio A, McNair C, Willan A, Ballantyne M, Widger K, Sidani S, Estabrooks C, Synnes A, Squires J, Victor C, Riahi S. The minimally effective dose of sucrose for procedural pain relief in neonates: a randomized controlled trial. BMC Pediatr. 2018 02 23; 18(1):85. PMID: 29475433.
      View in: PubMed
    9. Chan KKW, Xie F, Willan AR, Pullenayegum EM. Conducting EQ-5D Valuation Studies in Resource-Constrained Countries: The Potential Use of Shrinkage Estimators to Reduce Sample Size. Med Decis Making. 2018 01; 38(1):26-33. PMID: 28823185.
      View in: PubMed
    10. Hall NJ, Eaton S, Abbo O, Arnaud AP, Beaudin M, Brindle M, Bütter A, Davies D, Jancelewicz T, Johnson K, Keijzer R, Lapidus-Krol E, Offringa M, Piché N, Rintala R, Skarsgard E, Svensson JF, Ungar WJ, Wester T, Willan AR, Zani A, St Peter SD, Pierro A. Appendectomy versus non-operative treatment for acute uncomplicated appendicitis in children: study protocol for a multicentre, open-label, non-inferiority, randomised controlled trial. BMJ Paediatr Open. 2017; 1(1). PMID: 29637088.
      View in: PubMed
    11. Henderson JL, Cheung A, Cleverley K, Chaim G, Moretti ME, de Oliveira C, Hawke LD, Willan AR, O'Brien D, Heffernan O, Herzog T, Courey L, McDonald H, Grant E, Szatmari P. Integrated collaborative care teams to enhance service delivery to youth with mental health and substance use challenges: protocol for a pragmatic randomised controlled trial. BMJ Open. 2017 02 06; 7(2):e014080. PMID: 28167747.
      View in: PubMed
    12. Mei-Dan E, Asztalos EV, Willan AR, Barrett JF. The effect of induction method in twin pregnancies: a secondary analysis for the twin birth study. BMC Pregnancy Childbirth. 2017 01 06; 17(1):9. PMID: 28061767.
      View in: PubMed
    13. Chan KK, Xie F, Willan AR, Pullenayegum EM. Underestimation of Variance of Predicted Health Utilities Derived from Multiattribute Utility Instruments. Med Decis Making. 2017 04; 37(3):262-272. PMID: 27216582.
      View in: PubMed
    14. Willan AR. Accounting for treatment by center interaction in sample size determinations and the use of surrogate outcomes in the pessary for the prevention of preterm birth trial: a simulation study. Trials. 2016 07 05; 17(1):310. PMID: 27378231; PMCID: PMC4932689.
    15. Schuh S, Sweeney J, Freedman SB, Coates AL, Johnson DW, Thompson G, Gravel J, Ducharme FM, Zemek R, Plint AC, Beer D, Klassen T, Curtis S, Black K, Nicksy D, Willan AR. Magnesium nebulization utilization in management of pediatric asthma (MagNUM PA) trial: study protocol for a randomized controlled trial. Trials. 2016 05 24; 17(1):261. PMID: 27220675; PMCID: PMC4879727.
    16. Freedman SB, Willan AR, Boutis K, Schuh S. Effect of Dilute Apple Juice and Preferred Fluids vs Electrolyte Maintenance Solution on Treatment Failure Among Children With Mild Gastroenteritis: A Randomized Clinical Trial. JAMA. 2016 May 10; 315(18):1966-74. PMID: 27131100.
      View in: PubMed
    17. Escott BG, Richmond SA, Willan AR, Ravi B, Howard AW. The impact of pedestrian countdown signals on single and two vehicle motor vehicle collisions: a quasi-experimental study. Int J Inj Contr Saf Promot. 2017 Dec; 24(4):429-434. PMID: 27142464.
      View in: PubMed
    18. Eckermann S, Willan AR. Expected Value of Sample Information with Imperfect Implementation: Improving Practice and Reducing Uncertainty with Appropriate Counterfactual Consideration. Med Decis Making. 2016 04; 36(3):282-3. PMID: 26929164.
      View in: PubMed
    19. Hutton EK, Hannah ME, Ross S, Joseph KS, Ohlsson A, Asztalos E, Willan AR, Allen AC, Armson BA, Gafni A, Mangoff K, Sanchez JJ, Barrett JF. Re: Maternal outcomes at 3 months after planned caesarean section versus planned vaginal birth for twin pregnancies in the Twin Birth Study: a randomised controlled trial: Counselling is difficult when outcomes are associated with mode of delivery and not the plan of mode of delivery. BJOG. 2016 Mar; 123(4):644. PMID: 26914900.
      View in: PubMed
    20. Asztalos EV, Hannah ME, Hutton EK, Willan AR, Allen AC, Armson BA, Gafni A, Joseph KS, Ohlsson A, Ross S, Sanchez JJ, Mangoff K, Barrett JF. Twin Birth Study: 2-year neurodevelopmental follow-up of the randomized trial of planned cesarean or planned vaginal delivery for twin pregnancy. Am J Obstet Gynecol. 2016 Mar; 214(3):371.e1-371.e19. PMID: 26830380.
      View in: PubMed
    21. Hutton EK, Hannah ME, Ross S, Joseph KS, Ohlsson A, Asztalos EV, Willan AR, Allen AC, Armson BA, Gafni A, Mangoff K, Sanchez JJ, Barrett JF. Maternal outcomes at 3 months after planned caesarean section versus planned vaginal birth for twin pregnancies in the Twin Birth Study: a randomised controlled trial. BJOG. 2015 Nov; 122(12):1653-62. PMID: 26328526.
      View in: PubMed
    22. Roth DE, Gernand AD, Morris SK, Pezzack B, Islam MM, Dimitris MC, Shanta SS, Zlotkin SH, Willan AR, Ahmed T, Shah PS, Murphy KE, Weksberg R, Choufani S, Shah R, Al Mahmud A. Maternal vitamin D supplementation during pregnancy and lactation to promote infant growth in Dhaka, Bangladesh (MDIG trial): study protocol for a randomized controlled trial. Trials. 2015 Jul 14; 16:300. PMID: 26169781; PMCID: PMC4499946.
    23. Boutis K, von Keyserlingk C, Willan A, Narayanan UG, Brison R, Grootendorst P, Plint AC, Parker M, Goeree R. Cost Consequence Analysis of Implementing the Low Risk Ankle Rule in Emergency Departments. Ann Emerg Med. 2015 Nov; 66(5):455-463.e4. PMID: 26187612.
      View in: PubMed
    24. Parshuram CS, Dryden-Palmer K, Farrell C, Gottesman R, Gray M, Hutchison JS, Helfaer M, Hunt E, Joffe A, Lacroix J, Nadkarni V, Parkin P, Wensley D, Willan AR. Evaluating processes of care and outcomes of children in hospital (EPOCH): study protocol for a randomized controlled trial. Trials. 2015 Jun 02; 16:245. PMID: 26033094; PMCID: PMC4458338.
    25. Freedman SB, Sherman PM, Willan A, Johnson D, Gouin S, Schuh S. Emergency Department Treatment of Children With Diarrhea Who Attend Day Care: A Randomized Multidose Trial of a Lactobacillus helveticus and Lactobacillus rhamnosus Combination Probiotic. Clin Pediatr (Phila). 2015 Oct; 54(12):1158-66. PMID: 25669920.
      View in: PubMed
    26. Parshuram CS, Amaral AC, Ferguson ND, Baker GR, Etchells EE, Flintoft V, Granton J, Lingard L, Kirpalani H, Mehta S, Moldofsky H, Scales DC, Stewart TE, Willan AR, Friedrich JO. Patient safety, resident well-being and continuity of care with different resident duty schedules in the intensive care unit: a randomized trial. CMAJ. 2015 Mar 17; 187(5):321-9. PMID: 25667258; PMCID: PMC4361104.
    27. Schuh S, Freedman S, Coates A, Allen U, Parkin PC, Stephens D, Ungar W, DaSilva Z, Willan AR. Effect of oximetry on hospitalization in bronchiolitis: a randomized clinical trial. JAMA. 2014 Aug 20; 312(7):712-8. PMID: 25138332.
      View in: PubMed
    28. Asztalos E, Willan A, Murphy K, Matthews S, Ohlsson A, Saigal S, Armson A, Kelly E, Delisle MF, Gafni A, Lee S, Sananes R, Rovet J, Guselle P, Amankwah K. Association between gestational age at birth, antenatal corticosteroids, and outcomes at 5 years: multiple courses of antenatal corticosteroids for preterm birth study at 5 years of age (MACS-5). BMC Pregnancy Childbirth. 2014 Aug 13; 14:272. PMID: 25123162; PMCID: PMC4261573.
    29. Abrahamyan L, Willan AR, Beyene J, Mclimont M, Blanchette V, Feldman BM. Using value-of-information methods when the disease is rare and the treatment is expensive--the example of hemophilia A. J Gen Intern Med. 2014 Aug; 29 Suppl 3:S767-73. PMID: 25029970; PMCID: PMC4124117.
    30. Freedman SB, Williamson-Urquhart S, Schuh S, Sherman PM, Farion KJ, Gouin S, Willan AR, Goeree R, Johnson DW, Black K, Schnadower D, Gorelick MH. Impact of emergency department probiotic treatment of pediatric gastroenteritis: study protocol for the PROGUT (Probiotic Regimen for Outpatient Gastroenteritis Utility of Treatment) randomized controlled trial. Trials. 2014 May 14; 15:170. PMID: 24885220; PMCID: PMC4037747.
    31. Asztalos EV, Willan AR, Matthews SG. More evidence that unnecessary antenatal treatments cause harm--reply. JAMA Pediatr. 2014 Apr; 168(4):389-90. PMID: 24710588.
      View in: PubMed
    32. Barrett JF, Willan AR, Joseph KS. Planned cesarean or vaginal delivery for twin pregnancy. N Engl J Med. 2014 01 16; 370(3):280. PMID: 24428474.
      View in: PubMed
    33. Chen MH, Willan AR. Value of information methods for assessing a new diagnostic test. Stat Med. 2014 May 20; 33(11):1801-15. PMID: 24403241.
      View in: PubMed
    34. Chan KK, Willan AR, Gupta M, Pullenayegum E. Underestimation of uncertainties in health utilities derived from mapping algorithms involving health-related quality-of-life measures: statistical explanations and potential remedies. Med Decis Making. 2014 10; 34(7):863-72. PMID: 24407513.
      View in: PubMed
    35. Asztalos EV, Murphy KE, Willan AR, Matthews SG, Ohlsson A, Saigal S, Armson BA, Kelly EN, Delisle MF, Gafni A, Lee SK, Sananes R, Rovet J, Guselle P, Amankwah K, Saleem M, Sanchez J. Multiple courses of antenatal corticosteroids for preterm birth study: outcomes in children at 5 years of age (MACS-5). JAMA Pediatr. 2013 Dec; 167(12):1102-10. PMID: 24126948.
      View in: PubMed
    36. Barrett JF, Hannah ME, Hutton EK, Willan AR, Allen AC, Armson BA, Gafni A, Joseph KS, Mason D, Ohlsson A, Ross S, Sanchez JJ, Asztalos EV. A randomized trial of planned cesarean or vaginal delivery for twin pregnancy. N Engl J Med. 2013 Oct 03; 369(14):1295-305. PMID: 24088091.
      View in: PubMed
    37. Richmond SA, Willan AR, Rothman L, Camden A, Buliung R, Macarthur C, Howard A. The impact of pedestrian countdown signals on pedestrian-motor vehicle collisions: a reanalysis of data from a quasi-experimental study. Inj Prev. 2014 Jun; 20(3):155-8. PMID: 24065777; PMCID: PMC4033273.
    38. Boutis K, Grootendorst P, Willan A, Plint AC, Babyn P, Brison RJ, Sayal A, Parker M, Mamen N, Schuh S, Grimshaw J, Johnson D, Narayanan U. Effect of the Low Risk Ankle Rule on the frequency of radiography in children with ankle injuries. CMAJ. 2013 Oct 15; 185(15):E731-8. PMID: 23939215; PMCID: PMC3796622.
    39. Eckermann S, Willan AR. Optimal global value of information trials: better aligning manufacturer and decision maker interests and enabling feasible risk sharing. Pharmacoeconomics. 2013 May; 31(5):393-401. PMID: 23529209.
      View in: PubMed
    40. Stremler R, Hodnett E, Kenton L, Lee K, Weiss S, Weston J, Willan A. Effect of behavioural-educational intervention on sleep for primiparous women and their infants in early postpartum: multisite randomised controlled trial. BMJ. 2013 Mar 20; 346:f1164. PMID: 23516146; PMCID: PMC3603553.
    41. Ballantyne M, Stevens B, Guttmann A, Willan AR, Rosenbaum P. Maternal and infant predictors of attendance at Neonatal Follow-Up programmes. Child Care Health Dev. 2014 Mar; 40(2):250-8. PMID: 23294101.
      View in: PubMed
    42. Chen MH, Willan AR. Determining optimal sample sizes for multistage adaptive randomized clinical trials from an industry perspective using value of information methods. Clin Trials. 2013 Feb; 10(1):54-62. PMID: 23263520.
      View in: PubMed
    43. Hossain A, Willan AR, Beyene J. A flexible nonparametric approach to find candidate genes associated with disease in microarray experiments. J Bioinform Comput Biol. 2013 Apr; 11(2):1250021. PMID: 23600812.
      View in: PubMed
    44. Atenafu EG, Hamid JS, To T, Willan AR, Feldman BM, Beyene J. Bias-corrected estimator for intraclass correlation coefficient in the balanced one-way random effects model. BMC Med Res Methodol. 2012 Aug 20; 12:126. PMID: 22905752; PMCID: PMC3554464.
    45. Ungar WJ, Boydell K, Dell S, Feldman BM, Marshall D, Willan A, Wright JG. A parent-child dyad approach to the assessment of health status and health-related quality of life in children with asthma. Pharmacoeconomics. 2012 Aug 01; 30(8):697-712. PMID: 22788260; PMCID: PMC4931918.
    46. Willan AR, Eckermann S. Value of information and pricing new healthcare interventions. Pharmacoeconomics. 2012 Jun 01; 30(6):447-59. PMID: 22591129.
      View in: PubMed
    47. Willan AR, Goeree R, Boutis K. Value of information methods for planning and analyzing clinical studies optimize decision making and research planning. J Clin Epidemiol. 2012 Aug; 65(8):870-6. PMID: 22609138.
      View in: PubMed
    48. Murphy KE, Willan AR, Hannah ME, Ohlsson A, Kelly EN, Matthews SG, Saigal S, Asztalos E, Ross S, Delisle MF, Amankwah K, Guselle P, Gafni A, Lee SK, Armson BA. Effect of antenatal corticosteroids on fetal growth and gestational age at birth. Obstet Gynecol. 2012 May; 119(5):917-23. PMID: 22525902.
      View in: PubMed
    49. Feldman BM, Berger K, Bohn R, Carcao M, Fischer K, Gringeri A, Hoots K, Mantovani L, Willan AR, Schramm W. Haemophilia prophylaxis: how can we justify the costs? Haemophilia. 2012 Sep; 18(5):680-4. PMID: 22507524.
      View in: PubMed
    50. Ballantyne M, Stevens B, Guttmann A, Willan AR, Rosenbaum P. Transition to neonatal follow-up programs: is attendance a problem? J Perinat Neonatal Nurs. 2012 Jan-Mar; 26(1):90-8. PMID: 22293647.
      View in: PubMed
    51. Freedman SB, Parkin PC, Willan AR, Schuh S. Rapid versus standard intravenous rehydration in paediatric gastroenteritis: pragmatic blinded randomised clinical trial. BMJ. 2011 Nov 17; 343:d6976. PMID: 22094316; PMCID: PMC3219422.
    52. Willan AR. Sample size determination for cost-effectiveness trials. Pharmacoeconomics. 2011 Nov; 29(11):933-49. PMID: 21988292.
      View in: PubMed
    53. Willan AR, Eckermann S. Accounting for between-study variation in incremental net benefit in value of information methodology. Health Econ. 2012 Oct; 21(10):1183-95. PMID: 21882285.
      View in: PubMed
    54. Murphy KE, Hannah ME, Willan AR, Ohlsson A, Kelly EN, Matthews SG, Saigal S, Asztalos E, Ross S, Delisle MF, Tomat L, Amankwah K, Guselle P, Gafni A, Lee SK, Armson BA. Maternal side-effects after multiple courses of antenatal corticosteroids (MACS): the three-month follow-up of women in the randomized controlled trial of MACS for preterm birth study. J Obstet Gynaecol Can. 2011 Sep; 33(9):909-21. PMID: 21923988.
      View in: PubMed
    55. Eckermann S, Willan AR. Presenting evidence and summary measures to best inform societal decisions when comparing multiple strategies. Pharmacoeconomics. 2011 Jul; 29(7):563-77. PMID: 21671686.
      View in: PubMed
    56. von Keyserlingk C, Boutis K, Willan AR, Hopkins RB, Goeree R. Cost-effectiveness analysis of cast versus splint in children with acceptably angulated wrist fractures. Int J Technol Assess Health Care. 2011 Apr; 27(2):101-7. PMID: 21447261.
      View in: PubMed
    57. Hutton EK, Hannah ME, Ross SJ, Delisle MF, Carson GD, Windrim R, Ohlsson A, Willan AR, Gafni A, Sylvestre G, Natale R, Barrett Y, Pollard JK, Dunn MS, Turtle P. The Early External Cephalic Version (ECV) 2 Trial: an international multicentre randomised controlled trial of timing of ECV for breech pregnancies. BJOG. 2011 Apr; 118(5):564-77. PMID: 21291506; PMCID: PMC3085121.
    58. Eckermann S, Coory M, Willan AR. Consistently estimating absolute risk difference when translating evidence to jurisdictions of interest. Pharmacoeconomics. 2011 Feb; 29(2):87-96. PMID: 21166479.
      View in: PubMed
    59. Harris SB, Kapor J, Lank CN, Willan AR, Houston T. Clinical inertia in patients with T2DM requiring insulin in family practice. Can Fam Physician. 2010 Dec; 56(12):e418-24. PMID: 21156883; PMCID: PMC3001949.
    60. Abrahamyan L, Beyene J, Feng J, Chon Y, Willan AR, Schmeling H, Horneff G, Keystone EC, Feldman BM. Response times follow lognormal or gamma distribution in arthritis patients. J Clin Epidemiol. 2010 Dec; 63(12):1363-9. PMID: 20430577.
      View in: PubMed
    61. Asztalos EV, Murphy KE, Hannah ME, Willan AR, Matthews SG, Ohlsson A, Kelly EN, Saigal S, Ross S, Delisle MF, Amankwah K, Guselle P, Gafni A, Lee SK, Armson BA, Sananes R, Tomat L. Multiple courses of antenatal corticosteroids for preterm birth study: 2-year outcomes. Pediatrics. 2010 Nov; 126(5):e1045-55. PMID: 20956409.
      View in: PubMed
    62. Abrahamyan L, Li CS, Beyene J, Willan AR, Feldman BM. Survival distributions impact the power of randomized placebo-phase design and parallel groups randomized clinical trials. J Clin Epidemiol. 2011 Mar; 64(3):286-92. PMID: 20926258.
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    63. Boutis K, Willan A, Babyn P, Goeree R, Howard A. Cast versus splint in children with minimally angulated fractures of the distal radius: a randomized controlled trial. CMAJ. 2010 Oct 05; 182(14):1507-12. PMID: 20823169; PMCID: PMC2950182.
    64. Willan AR, Eckermann S. Optimal clinical trial design using value of information methods with imperfect implementation. Health Econ. 2010 May; 19(5):549-61. PMID: 19399753.
      View in: PubMed
    65. Eckermann S, Karnon J, Willan AR. The value of value of information: best informing research design and prioritization using current methods. Pharmacoeconomics. 2010; 28(9):699-709. PMID: 20629473.
      View in: PubMed
    66. Howard AW, Macarthur C, Rothman L, Willan A, Macpherson AK. School playground surfacing and arm fractures in children: a cluster randomized trial comparing sand to wood chip surfaces. PLoS Med. 2009 Dec; 6(12):e1000195. PMID: 20016688; PMCID: PMC2784292.
    67. Lynd LD, Najafzadeh M, Colley L, Byrne MF, Willan AR, Sculpher MJ, Johnson FR, Hauber AB. Using the incremental net benefit framework for quantitative benefit-risk analysis in regulatory decision-making--a case study of alosetron in irritable bowel syndrome. Value Health. 2010 Jun-Jul; 13(4):411-7. PMID: 19744297.
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    68. Schuh S, Willan AR, Stephens D, Dick PT, Coates A. Can montelukast shorten prednisolone therapy in children with mild to moderate acute asthma? A randomized controlled trial. J Pediatr. 2009 Dec; 155(6):795-800. PMID: 19656525.
      View in: PubMed
    69. Eckermann S, Willan AR. Globally optimal trial design for local decision making. Health Econ. 2009 Feb; 18(2):203-16. PMID: 18435429.
      View in: PubMed
    70. Eckermann S, Coory M, Willan AR. Indirect comparison: relative risk fallacies and odds solution. J Clin Epidemiol. 2009 Oct; 62(10):1031-6. PMID: 19179043.
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    71. Murphy KE, Hannah ME, Willan AR, Hewson SA, Ohlsson A, Kelly EN, Matthews SG, Saigal S, Asztalos E, Ross S, Delisle MF, Amankwah K, Guselle P, Gafni A, Lee SK, Armson BA. Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial. Lancet. 2008 Dec 20; 372(9656):2143-51. PMID: 19101390.
      View in: PubMed
    72. Nagel K, Willan AR, Lappan J, Korz L, Buckley N, Barr RD. Pediatric oncology sedation trial (POST): A double-blind randomized study. Pediatr Blood Cancer. 2008 Nov; 51(5):634-8. PMID: 18649369.
      View in: PubMed
    73. Hodnett ED, Stremler R, Willan AR, Weston JA, Lowe NK, Simpson KR, Fraser WD, Gafni A. Effect on birth outcomes of a formalised approach to care in hospital labour assessment units: international, randomised controlled trial. BMJ. 2008 Aug 28; 337:a1021. PMID: 18755762; PMCID: PMC2526182.
    74. Willan AR, Kowgier ME. Cost-effectiveness analysis of a multinational RCT with a binary measure of effectiveness and an interacting covariate. Health Econ. 2008 Jul; 17(7):777-91. PMID: 17764096.
      View in: PubMed
    75. Eckermann S, Willan AR. The option value of delay in health technology assessment. Med Decis Making. 2008 May-Jun; 28(3):300-5. PMID: 18480035.
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    76. Eckermann S, Briggs A, Willan AR. Health technology assessment in the cost-disutility plane. Med Decis Making. 2008 Mar-Apr; 28(2):172-81. PMID: 18356312.
      View in: PubMed
    77. Willan AR. Optimal sample size determinations from an industry perspective based on the expected value of information. Clin Trials. 2008; 5(6):587-94. PMID: 19029207.
      View in: PubMed
    78. Willan A, Kowgier M. Determining optimal sample sizes for multi-stage randomized clinical trials using value of information methods. Clin Trials. 2008; 5(4):289-300. PMID: 18697843.
      View in: PubMed
    79. Eckermann S, Willan AR. Time and expected value of sample information wait for no patient. Value Health. 2008 May-Jun; 11(3):522-6. PMID: 18179665.
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    80. Nicholson A, Berger K, Bohn R, Carcao M, Fischer K, Gringeri A, Hoots K, Mantovani L, Schramm W, van Hout BA, Willan AR, Feldman BM. Recommendations for reporting economic evaluations of haemophilia prophylaxis: a nominal groups consensus statement on behalf of the Economics Expert Working Group of The International Prophylaxis Study Group. Haemophilia. 2008 Jan; 14(1):127-32. PMID: 18005148.
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    81. Pullenayegum EM, Willan AR. Semi-parametric regression models for cost-effectiveness analysis: improving the efficiency of estimation from censored data. Stat Med. 2007 Jul 30; 26(17):3274-99. PMID: 17309112.
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    82. Magee LA, von Dadelszen P, Chan S, Gafni A, Gruslin A, Helewa M, Hewson S, Kavuma E, Lee SK, Logan AG, McKay D, Moutquin JM, Ohlsson A, Rey E, Ross S, Singer J, Willan AR, Hannah ME. The Control of Hypertension In Pregnancy Study pilot trial. BJOG. 2007 Jun; 114(6):770, e13-20. PMID: 17516972.
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    83. Boutis K, Willan AR, Babyn P, Narayanan UG, Alman B, Schuh S. A randomized, controlled trial of a removable brace versus casting in children with low-risk ankle fractures. Pediatrics. 2007 Jun; 119(6):e1256-63. PMID: 17545357.
      View in: PubMed
    84. Su M, McLeod L, Ross S, Willan A, Hannah WJ, Hutton EK, Hewson SA, McKay D, Hannah ME. Factors associated with maternal morbidity in the Term Breech Trial. J Obstet Gynaecol Can. 2007 Apr; 29(4):324-330. PMID: 17475125.
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    85. Eckermann S, Willan AR. Expected value of information and decision making in HTA. Health Econ. 2007 Feb; 16(2):195-209. PMID: 16981193.
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    86. Dolovich L, Sabharwal M, Agro K, Foster G, Lee A, McCarthy L, Willan AR. The effect of pharmacist education on asthma treatment plans for simulated patients. Pharm World Sci. 2007 Jun; 29(3):228-39. PMID: 17242854.
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    87. Willan AR. Clinical decision making and the expected value of information. Clin Trials. 2007; 4(3):279-85. PMID: 17715257.
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    88. Magee LA, von Dadelszen P, Chan S, Gafni A, Gruslin A, Helewa M, Hewson S, Kavuma E, Lee SK, Logan AG, McKay D, Moutquin JM, Ohlsson A, Rey E, Ross S, Singer J, Willan AR, Hannah ME, Group FT. Women's views of their experiences in the CHIPS (Control of Hypertension in Pregnancy Study) Pilot Trial. Hypertens Pregnancy. 2007; 26(4):371-87. PMID: 18066957.
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    89. Stremler R, Hodnett E, Lee K, MacMillan S, Mill C, Ongcangco L, Willan A. A behavioral-educational intervention to promote maternal and infant sleep: a pilot randomized, controlled trial. Sleep. 2006 Dec; 29(12):1609-15. PMID: 17252892.
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    90. McCarter H, Furlong W, Whitton AC, Feeny D, DePauw S, Willan AR, Barr RD. Health status measurements at diagnosis as predictors of survival among adults with brain tumors. J Clin Oncol. 2006 Aug 01; 24(22):3636-43. PMID: 16877731.
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    91. Sofronas M, Ichord RN, Fullerton HJ, Lynch JK, Massicotte MP, Willan AR, deVeber G. Pediatric stroke initiatives and preliminary studies: What is known and what is needed? Pediatr Neurol. 2006 Jun; 34(6):439-45. PMID: 16765821.
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    92. Willan AR. Statistical analysis of cost-effectiveness data from randomized clinical trials. Expert Rev Pharmacoecon Outcomes Res. 2006 Jun; 6(3):337-46. PMID: 20528526.
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    93. Palencia R, Gafni A, Hannah ME, Ross S, Willan AR, Hewson S, McKay D, Hannah W, Whyte H, Amankwah K, Cheng M, Guselle P, Helewa M, Hodnett ED, Hutton EK, Kung R, Saigal S. The costs of planned cesarean versus planned vaginal birth in the Term Breech Trial. CMAJ. 2006 Apr 11; 174(8):1109-13. PMID: 16606959; PMCID: PMC1421479.
    94. Okun N, Mitchell BF, Willan AR, Armson BA, Hannah M. Perspectives on the management of the short cervix identified by transvaginal ultrasound during pregnancy: an update for Canadian obstetrical caregivers. J Obstet Gynaecol Can. 2006 Mar; 28(3):203-205. PMID: 16650358.
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    95. Willan AR, Goeree R, Pullenayegum EM, McBurney C, Blackhouse G. Economic evaluation of rivastigmine in patients with Parkinson's disease dementia. Pharmacoeconomics. 2006; 24(1):93-106. PMID: 16445306.
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    96. Manca A, Willan AR. 'Lost in translation': accounting for between-country differences in the analysis of multinational cost-effectiveness data. Pharmacoeconomics. 2006; 24(11):1101-19. PMID: 17067195.
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    97. Stremler R, Hodnett E, Petryshen P, Stevens B, Weston J, Willan AR. Randomized controlled trial of hands-and-knees positioning for occipitoposterior position in labor. Birth. 2005 Dec; 32(4):243-51. PMID: 16336365.
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    98. Pinto EM, Willan AR, O'Brien BJ. Cost-effectiveness analysis for multinational clinical trials. Stat Med. 2005 Jul 15; 24(13):1965-82. PMID: 15803442.
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    99. Willan AR, Pinto EM. The value of information and optimal clinical trial design. Stat Med. 2005 Jun 30; 24(12):1791-806. PMID: 15806619.
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    100. Howard AW, MacArthur C, Willan A, Rothman L, Moses-McKeag A, MacPherson AK. The effect of safer play equipment on playground injury rates among school children. CMAJ. 2005 May 24; 172(11):1443-6. PMID: 15911858; PMCID: PMC557979.
    101. Willan AR, Pinto EM, O'Brien BJ, Kaul P, Goeree R, Lynd L, Armstrong PW. Country specific cost comparisons from multinational clinical trials using empirical Bayesian shrinkage estimation: the Canadian ASSENT-3 economic analysis. Health Econ. 2005 Apr; 14(4):327-38. PMID: 15685652.
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    102. Taylor DR, Cowan JO, Greene JM, Willan AR, Sears MR. Asthma in remission: can relapse in early adulthood be predicted at 18 years of age? Chest. 2005 Mar; 127(3):845-50. PMID: 15764766.
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    103. Reed SD, Anstrom KJ, Bakhai A, Briggs AH, Califf RM, Cohen DJ, Drummond MF, Glick HA, Gnanasakthy A, Hlatky MA, O'Brien BJ, Torti FM, Tsiatis AA, Willan AR, Mark DB, Schulman KA. Conducting economic evaluations alongside multinational clinical trials: toward a research consensus. Am Heart J. 2005 Mar; 149(3):434-43. PMID: 15864231.
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    104. Hodnett ED, Hannah ME, Hewson S, Whyte H, Amankwah K, Cheng M, Gafni A, Guselle P, Helewa M, Hutton E, Kung R, McKay D, Saigal S, Willan A. Mothers' views of their childbirth experiences 2 years after planned Caesarean versus planned vaginal birth for breech presentation at term, in the international randomized Term Breech Trial. J Obstet Gynaecol Can. 2005 Mar; 27(3):224-31. PMID: 15937595.
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    105. Willan AR, Lin DY, Manca A. Regression methods for cost-effectiveness analysis with censored data. Stat Med. 2005 Jan 15; 24(1):131-45. PMID: 15515137.
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    106. O'Hagan A, McCabe C, Akehurst R, Brennan A, Briggs A, Claxton K, Fenwick E, Fryback D, Sculpher M, Spiegelhalter D, Willan A. Incorporation of uncertainty in health economic modelling studies. Pharmacoeconomics. 2005; 23(6):529-36. PMID: 15960550.
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    107. Su M, Hannah WJ, Willan A, Ross S, Hannah ME. Planned caesarean section decreases the risk of adverse perinatal outcome due to both labour and delivery complications in the Term Breech Trial. BJOG. 2004 Oct; 111(10):1065-74. PMID: 15383108.
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    108. Whyte H, Hannah ME, Saigal S, Hannah WJ, Hewson S, Amankwah K, Cheng M, Gafni A, Guselle P, Helewa M, Hodnett ED, Hutton E, Kung R, McKay D, Ross S, Willan A. Outcomes of children at 2 years after planned cesarean birth versus planned vaginal birth for breech presentation at term: the International Randomized Term Breech Trial. Am J Obstet Gynecol. 2004 Sep; 191(3):864-71. PMID: 15467555.
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    109. Hannah ME, Whyte H, Hannah WJ, Hewson S, Amankwah K, Cheng M, Gafni A, Guselle P, Helewa M, Hodnett ED, Hutton E, Kung R, McKay D, Ross S, Saigal S, Willan A. Maternal outcomes at 2 years after planned cesarean section versus planned vaginal birth for breech presentation at term: the international randomized Term Breech Trial. Am J Obstet Gynecol. 2004 Sep; 191(3):917-27. PMID: 15467565.
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    110. Briggs A, Buxton M, Drummond M, Goeree R, Sculpher MJ, Willan AR. Unfinished symphony: a tribute to the life and career of Bernie O'Brien (1959-2004). Med Decis Making. 2004 Sep-Oct; 24(5):538-44. PMID: 15359004.
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    111. Whelan T, Levine M, Willan A, Gafni A, Sanders K, Mirsky D, Chambers S, O'Brien MA, Reid S, Dubois S. Effect of a decision aid on knowledge and treatment decision making for breast cancer surgery: a randomized trial. JAMA. 2004 Jul 28; 292(4):435-41. PMID: 15280341.
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    112. Grunfeld E, Coyle D, Whelan T, Clinch J, Reyno L, Earle CC, Willan A, Viola R, Coristine M, Janz T, Glossop R. Family caregiver burden: results of a longitudinal study of breast cancer patients and their principal caregivers. CMAJ. 2004 Jun 08; 170(12):1795-801. PMID: 15184333; PMCID: PMC419766.
    113. Willan AR. Incremental net benefit in the analysis of economic data from clinical trials, with application to the CADET-Hp trial. Eur J Gastroenterol Hepatol. 2004 Jun; 16(6):543-9. PMID: 15167155.
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    114. Chiba N, Gralnek IM, Moayyedi P, Provenzale D, Inadomi JM, Willan AR, Briggs AH, Kim WR. A glossary of economic terms. Eur J Gastroenterol Hepatol. 2004 Jun; 16(6):563-5. PMID: 15167157.
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    115. Willan AR, Briggs AH, Hoch JS. Regression methods for covariate adjustment and subgroup analysis for non-censored cost-effectiveness data. Health Econ. 2004 May; 13(5):461-75. PMID: 15127426.
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    116. Akoury HA, Hannah ME, Chitayat D, Thomas M, Winsor E, Ferris LE, Einarson TR, Seaward PG, Ryan G, Willan AR, Windrim R. Randomized controlled trial of misoprostol for second-trimester pregnancy termination associated with fetal malformation. Am J Obstet Gynecol. 2004 Mar; 190(3):755-62. PMID: 15042010.
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    117. Wise MR, Shapiro H, Bodley J, Pittini R, McKay D, Willan A, Hannah ME. Factors affecting academic promotion in obstetrics and gynaecology in Canada. J Obstet Gynaecol Can. 2004 Feb; 26(2):127-36. PMID: 14965478.
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    118. Caetano M, Ornstein MP, Von Dadelszen P, Hannah ME, Logan AG, Gruslin A, Willan A, Magee LA. A survey of Canadian practitioners regarding the management of the hypertensive disorders of pregnancy. Hypertens Pregnancy. 2004; 23(1):61-74. PMID: 15117601.
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    119. Caetano M, Ornstein MP, von Dadelszen P, Hannah ME, Logan AG, Gruslin A, Willan A, Magee LA. A survey of canadian practitioners regarding diagnosis and evaluation of the hypertensive disorders of pregnancy. Hypertens Pregnancy. 2004; 23(2):197-209. PMID: 15369652.
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    120. Sears MR, Greene JM, Willan AR, Wiecek EM, Taylor DR, Flannery EM, Cowan JO, Herbison GP, Silva PA, Poulton R. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med. 2003 Oct 09; 349(15):1414-22. PMID: 14534334.
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    121. Su M, McLeod L, Ross S, Willan A, Hannah WJ, Hutton E, Hewson S, Hannah ME. Factors associated with adverse perinatal outcome in the Term Breech Trial. Am J Obstet Gynecol. 2003 Sep; 189(3):740-5. PMID: 14526305.
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    122. Sellors J, Kaczorowski J, Sellors C, Dolovich L, Woodward C, Willan A, Goeree R, Cosby R, Trim K, Sebaldt R, Howard M, Hardcastle L, Poston J. A randomized controlled trial of a pharmacist consultation program for family physicians and their elderly patients. CMAJ. 2003 Jul 08; 169(1):17-22. PMID: 12847034; PMCID: PMC164937.
    123. Whelan T, Sawka C, Levine M, Gafni A, Reyno L, Willan A, Julian J, Dent S, Abu-Zahra H, Chouinard E, Tozer R, Pritchard K, Bodendorfer I. Helping patients make informed choices: a randomized trial of a decision aid for adjuvant chemotherapy in lymph node-negative breast cancer. J Natl Cancer Inst. 2003 Apr 16; 95(8):581-7. PMID: 12697850.
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    124. Willan AR, Chen EB, Cook RJ, Lin DY. Incremental net benefit in randomized clinical trials with quality-adjusted survival. Stat Med. 2003 Feb 15; 22(3):353-62. PMID: 12529868.
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    125. Cosby RH, Howard M, Kaczorowski J, Willan AR, Sellors JW. Randomizing patients by family practice: sample size estimation, intracluster correlation and data analysis. Fam Pract. 2003 Feb; 20(1):77-82. PMID: 12509376.
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    126. Willan AR, Lin DY, Cook RJ, Chen EB. Using inverse-weighting in cost-effectiveness analysis with censored data. Stat Methods Med Res. 2002 Dec; 11(6):539-51. PMID: 12516988.
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    127. Browman GP, Mohide EA, Willan A, Hodson I, Wong G, Grimard L, MacKenzie RG, El-Sayed S, Dunn E, Farrell S. Association between smoking during radiotherapy and prognosis in head and neck cancer: a follow-up study. Head Neck. 2002 Dec; 24(12):1031-7. PMID: 12454940.
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    128. Sears MR, Greene JM, Willan AR, Taylor DR, Flannery EM, Cowan JO, Herbison GP, Poulton R. Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study. Lancet. 2002 Sep 21; 360(9337):901-7. PMID: 12354471.
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    129. Hodnett ED, Lowe NK, Hannah ME, Willan AR, Stevens B, Weston JA, Ohlsson A, Gafni A, Muir HA, Myhr TL, Stremler R. Effectiveness of nurses as providers of birth labor support in North American hospitals: a randomized controlled trial. JAMA. 2002 Sep 18; 288(11):1373-81. PMID: 12234231.
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    130. Cranney A, Wells G, Willan A, Griffith L, Zytaruk N, Robinson V, Black D, Adachi J, Shea B, Tugwell P, Guyatt G. Meta-analyses of therapies for postmenopausal osteoporosis. II. Meta-analysis of alendronate for the treatment of postmenopausal women. Endocr Rev. 2002 Aug; 23(4):508-16. PMID: 12202465.
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    131. Douketis JD, Eikelboom JW, Quinlan DJ, Willan AR, Crowther MA. Short-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of prospective studies investigating symptomatic outcomes. Arch Intern Med. 2002 Jul 08; 162(13):1465-71. PMID: 12090882.
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    132. Hoch JS, Briggs AH, Willan AR. Something old, something new, something borrowed, something blue: a framework for the marriage of health econometrics and cost-effectiveness analysis. Health Econ. 2002 Jul; 11(5):415-30. PMID: 12112491.
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    133. DiCenso A, Guyatt G, Willan A, Griffith L. Interventions to reduce unintended pregnancies among adolescents: systematic review of randomised controlled trials. BMJ. 2002 Jun 15; 324(7351):1426. PMID: 12065267; PMCID: PMC115855.
    134. Hannah ME, Hannah WJ, Hodnett ED, Chalmers B, Kung R, Willan A, Amankwah K, Cheng M, Helewa M, Hewson S, Saigal S, Whyte H, Gafni A. Outcomes at 3 months after planned cesarean vs planned vaginal delivery for breech presentation at term: the international randomized Term Breech Trial. JAMA. 2002 Apr 10; 287(14):1822-31. PMID: 11939868.
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    135. O'Brien BJ, Gertsen K, Willan AR, Faulkner LA. Is there a kink in consumers' threshold value for cost-effectiveness in health care? Health Econ. 2002 Mar; 11(2):175-80. PMID: 11921315.
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    136. Willan AR, O'Brien BJ, Leyva RA. Cost-effectiveness analysis when the WTA is greater than the WTP. Stat Med. 2001 Nov 15; 20(21):3251-9. PMID: 11746316.
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    137. Aghajafari F, Murphy K, Willan A, Ohlsson A, Amankwah K, Matthews S, Hannah M. Multiple courses of antenatal corticosteroids: a systematic review and meta-analysis. Am J Obstet Gynecol. 2001 Nov; 185(5):1073-80. PMID: 11717636.
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    138. Willan AR. On the probability of cost-effectiveness using data from randomized clinical trials. BMC Med Res Methodol. 2001; 1:8. PMID: 11686854; PMCID: PMC58837.
    139. Willan AR. Broad-spectrum antibiotics in ORACLE. Lancet. 2001 Aug 11; 358(9280):502; author reply 503-4. PMID: 11515508.
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    140. Willan AR, Lin DY. Incremental net benefit in randomized clinical trials. Stat Med. 2001 Jun 15; 20(11):1563-74. PMID: 11391688.
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    141. Willan AR, O'Brien BJ. Cost prediction models for the comparison of two groups. Health Econ. 2001 Jun; 10(4):363-6. PMID: 11400259.
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    142. Feldman B, Wang E, Willan A, Szalai JP. The randomized placebo-phase design for clinical trials. J Clin Epidemiol. 2001 Jun; 54(6):550-7. PMID: 11377114.
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    143. Willan AR. Analysis, sample size, and power for estimating incremental net health benefit from clinical trial data. Control Clin Trials. 2001 Jun; 22(3):228-37. PMID: 11384787.
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    144. O'Brien BJ, Connolly SJ, Goeree R, Blackhouse G, Willan A, Yee R, Roberts RS, Gent M. Cost-effectiveness of the implantable cardioverter-defibrillator: results from the Canadian Implantable Defibrillator Study (CIDS). Circulation. 2001 Mar 13; 103(10):1416-21. PMID: 11245646.
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    145. Agro K, Blackhouse G, Goeree R, Willan AR, Huang JQ, Hunt RH, O'Brien BJ. Cost effectiveness in Canada of a multidrug prepackaged regimen (Hp-PAC)+ for Helicobacter pylori eradication. Pharmacoeconomics. 2001; 19(8):831-43. PMID: 11596835.
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    146. Hannah ME, Hannah WJ, Hewson SA, Hodnett ED, Saigal S, Willan AR. Planned caesarean section versus planned vaginal birth for breech presentation at term: a randomised multicentre trial. Term Breech Trial Collaborative Group. Lancet. 2000 Oct 21; 356(9239):1375-83. PMID: 11052579.
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    147. Kirpalani HM, Parkin PC, Willan AR, Fehlings DL, Rosenbaum PL, King D, Van Nie AJ. Quality of life in spina bifida: importance of parental hope. Arch Dis Child. 2000 Oct; 83(4):293-7. PMID: 10999858; PMCID: PMC1718506.
    148. Hannah ME, Hodnett ED, Willan A, Foster GA, Di Cecco R, Helewa M. Prelabor rupture of the membranes at term: expectant management at home or in hospital? The TermPROM Study Group. Obstet Gynecol. 2000 Oct; 96(4):533-8. PMID: 11004354.
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    149. Grunfeld E, Whelan TJ, Zitzelsberger L, Willan AR, Montesanto B, Evans WK. Cancer care workers in Ontario: prevalence of burnout, job stress and job satisfaction. CMAJ. 2000 Jul 25; 163(2):166-9. PMID: 10934978; PMCID: PMC80206.
    150. Carmichael FJ, Ali AC, Campbell JA, Langlois SF, Biro GP, Willan AR, Pierce CH, Greenburg AG. A phase I study of oxidized raffinose cross-linked human hemoglobin. Crit Care Med. 2000 Jul; 28(7):2283-92. PMID: 10921554.
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    151. Wilson K, Gibson N, Willan A, Cook D. Effect of smoking cessation on mortality after myocardial infarction: meta-analysis of cohort studies. Arch Intern Med. 2000 Apr 10; 160(7):939-44. PMID: 10761958.
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    152. Molloy DW, Guyatt GH, Russo R, Goeree R, O'Brien BJ, Bédard M, Willan A, Watson J, Patterson C, Harrison C, Standish T, Strang D, Darzins PJ, Smith S, Dubois S. Systematic implementation of an advance directive program in nursing homes: a randomized controlled trial. JAMA. 2000 Mar 15; 283(11):1437-44. PMID: 10732933.
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    153. O'Brien BJ, Willan A, Blackhouse G, Goeree R, Cohen M, Goodman S. Will the use of low-molecular-weight heparin (enoxaparin) in patients with acute coronary syndrome save costs in Canada? Am Heart J. 2000 Mar; 139(3):423-9. PMID: 10689256.
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    154. Guyatt GH, DiCenso A, Farewell V, Willan A, Griffith L. Randomized trials versus observational studies in adolescent pregnancy prevention. J Clin Epidemiol. 2000 Feb; 53(2):167-74. PMID: 10729689.
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    155. Siersted HC, Walker CM, O'Shaughnessy AD, Willan AR, Wiecek EM, Sears MR. Comparison of two standardized methods of methacholine inhalation challenge in young adults. Eur Respir J. 2000 Jan; 15(1):181-4. PMID: 10678643.
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    156. Goeree R, O'Brien B, Hunt R, Blackhouse G, Willan A, Watson J. Economic evaluation of long-term management strategies for erosive oesophagitis. Pharmacoeconomics. 1999 Dec; 16(6):679-97. PMID: 10724795.
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    157. O'Brien B, Levine M, Willan A, Goeree R, Haley S, Blackhouse G, Gent M. Economic evaluation of outpatient treatment with low-molecular-weight heparin for proximal vein thrombosis. Arch Intern Med. 1999 Oct 25; 159(19):2298-304. PMID: 10547169.
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    158. Whelan T, Levine M, Gafni A, Sanders K, Willan A, Mirsky D, Schnider D, McCready D, Reid S, Kobylecky A, Reed K. Mastectomy or lumpectomy? Helping women make informed choices. J Clin Oncol. 1999 Jun; 17(6):1727-35. PMID: 10561209.
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    159. Peleg D, Hannah ME, Hodnett ED, Foster GA, Willan AR, Farine D. Predictors of cesarean delivery after prelabor rupture of membranes at term. Obstet Gynecol. 1999 Jun; 93(6):1031-5. PMID: 10362176.
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    160. Willan AR, O'Brien BJ. Sample size and power issues in estimating incremental cost-effectiveness ratios from clinical trials data. Health Econ. 1999 May; 8(3):203-11. PMID: 10348415.
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    161. Zaza C, Sellick SM, Willan A, Reyno L, Browman GP. Health care professionals' familiarity with non-pharmacological strategies for managing cancer pain. Psychooncology. 1999 Mar-Apr; 8(2):99-111. PMID: 10335554.
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    162. Whelan TJ, Rath D, Willan A, Neimanis M, Czukar D, Levine M. Evaluation of a patient file folder to improve the dissemination of written information materials for cancer patients. Cancer. 1998 Oct 15; 83(8):1620-5. PMID: 9781957.
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    163. Melnikow J, Nuovo J, Willan AR, Chan BK, Howell LP. Natural history of cervical squamous intraepithelial lesions: a meta-analysis. Obstet Gynecol. 1998 Oct; 92(4 Pt 2):727-35. PMID: 9764690.
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    164. Barr RD, Halton J, Willan A, Cockshott WP, Gill G, Atkinson S. Impact of age and cranial irradiation on radiographic skeletal pathology in children with acute lymphoblastic leukemia. Med Pediatr Oncol. 1998 Jun; 30(6):347-50. PMID: 9589083.
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    165. Bloomfield DJ, Krahn MD, Neogi T, Panzarella T, Smith TJ, Warde P, Willan AR, Ernst S, Moore MJ, Neville A, Tannock IF. Economic evaluation of chemotherapy with mitoxantrone plus prednisone for symptomatic hormone-resistant prostate cancer: based on a Canadian randomized trial with palliative end points. J Clin Oncol. 1998 Jun; 16(6):2272-9. PMID: 9626231.
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    166. Gafni A, Goeree R, Myhr TL, Hannah ME, Blackhouse G, Willan AR, Weston JA, Wang EE, Hodnett ED, Hewson SA, Farine D, Ohlsson A. Induction of labour versus expectant management for prelabour rupture of the membranes at term: an economic evaluation. TERMPROM Study Group. Term Prelabour Rupture of the Membranes. CMAJ. 1997 Dec 01; 157(11):1519-25. PMID: 9400406; PMCID: PMC1228562.
    167. Hodnett ED, Hannah ME, Weston JA, Ohlsson A, Myhr TL, Wang EE, Hewson SA, Willan AR, Farine D. Women's evaluations of induction of labor versus expectant management for prelabor rupture of the membranes at term. TermPROM Study Group. Birth. 1997 Dec; 24(4):214-20. PMID: 9460311.
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    168. Whelan TJ, Mohide EA, Willan AR, Arnold A, Tew M, Sellick S, Gafni A, Levine MN. The supportive care needs of newly diagnosed cancer patients attending a regional cancer center. Cancer. 1997 Oct 15; 80(8):1518-24. PMID: 9338478.
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    169. Hannah ME, Ohlsson A, Wang EE, Matlow A, Foster GA, Willan AR, Hodnett ED, Weston JA, Farine D, Seaward PG. Maternal colonization with group B Streptococcus and prelabor rupture of membranes at term: the role of induction of labor. TermPROM Study Group. Am J Obstet Gynecol. 1997 Oct; 177(4):780-5. PMID: 9369819.
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    170. Mitchell-DiCenso A, Thomas BH, Devlin MC, Goldsmith CH, Willan A, Singer J, Marks S, Watters D, Hewson S. Evaluation of an educational program to prevent adolescent pregnancy. Health Educ Behav. 1997 Jun; 24(3):300-12. PMID: 9158975.
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    171. Willan AR, O'Brien BJ, Cook DJ. Benefit-risk ratios in the assessment of the clinical evidence of a new therapy. Control Clin Trials. 1997 Apr; 18(2):121-30. PMID: 9129856.
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    172. Parkin PC, Kirpalani HM, Rosenbaum PL, Fehlings DL, Van Nie A, Willan AR, King D. Development of a health-related quality of life instrument for use in children with spina bifida. Qual Life Res. 1997 Mar; 6(2):123-32. PMID: 9161112.
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    173. Mitchell-DiCenso A, Guyatt G, Marrin M, Goeree R, Willan A, Southwell D, Hewson S, Paes B, Rosenbaum P, Hunsberger M, Baumann A. A controlled trial of nurse practitioners in neonatal intensive care. Pediatrics. 1996 Dec; 98(6 Pt 1):1143-8. PMID: 8951267.
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    174. Clark RM, Whelan T, Levine M, Roberts R, Willan A, McCulloch P, Lipa M, Wilkinson RH, Mahoney LJ. Randomized clinical trial of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer: an update. Ontario Clinical Oncology Group. J Natl Cancer Inst. 1996 Nov 20; 88(22):1659-64. PMID: 8931610.
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    175. Johnston M, Harrison L, Moffat K, Willan A, Hirsh J. Reliability of the international normalized ratio for monitoring the induction phase of warfarin: comparison with the prothrombin time ratio. J Lab Clin Med. 1996 Aug; 128(2):214-7. PMID: 8765218.
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    176. Willan AR, O'Brien BJ. Confidence intervals for cost-effectiveness ratios: an application of Fieller's theorem. Health Econ. 1996 Jul-Aug; 5(4):297-305. PMID: 8880166.
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    177. Mohide EA, Whelan TJ, Rath D, Gafni A, Willan AR, Czukar D, Campbell IB, Okawara GS, Neimanis M, Levine MN. A randomised trial of two information packages distributed to new cancer patients before their initial appointment at a regional cancer centre. Br J Cancer. 1996 Jun; 73(12):1588-93. PMID: 8664135; PMCID: PMC2074537.
    178. Cook RJ, Willan AR. Design considerations in crossover trials with a single interim analysis and serial patient entry. Biometrics. 1996 Jun; 52(2):732-9. PMID: 8672709.
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    179. Levine MN, Gent M, Hirsh J, Weitz J, Turpie AG, Powers P, Neemeh J, Willan A, Skingley P. Ardeparin (low-molecular-weight heparin) vs graduated compression stockings for the prevention of venous thromboembolism. A randomized trial in patients undergoing knee surgery. Arch Intern Med. 1996 Apr 22; 156(8):851-6. PMID: 8774203.
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    180. Hannah ME, Ohlsson A, Farine D, Hewson SA, Hodnett ED, Myhr TL, Wang EE, Weston JA, Willan AR. Induction of labor compared with expectant management for prelabor rupture of the membranes at term. TERMPROM Study Group. N Engl J Med. 1996 Apr 18; 334(16):1005-10. PMID: 8598837.
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    181. Willan AR, Cruess AF, Ballantyne M. Argon green vs. krypton red laser photocoagulation for extrafoveal choroidal neovascularization secondary to age-related macular degeneration: 3-year results of a multicentre randomized trial. Canadian Ophthalmology Study Group. Can J Ophthalmol. 1996 Feb; 31(1):11-7. PMID: 8925479.
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    182. Savilo E, Harnish D, Desa D, Willan A, Barr R. Comparison of the prognostic significance of the Shimada classification and N-myc copy number in neuroblastoma. Int J Oncol. 1996 Feb; 8(2):343-7. PMID: 21544366.
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    183. Hannah ME, Ohlsson A, Willan A. Induction of labor versus expectant management: does it matter? Am J Obstet Gynecol. 1995 Jul; 173(1):352-3. PMID: 7631721.
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    184. Cook DJ, Guyatt GH, Jaeschke R, Reeve J, Spanier A, King D, Molloy DW, Willan A, Streiner DL. Determinants in Canadian health care workers of the decision to withdraw life support from the critically ill. Canadian Critical Care Trials Group. JAMA. 1995 Mar 01; 273(9):703-8. PMID: 7853627.
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    185. Hannah ME, Hannah WJ, Willan A. Comment on the effectiveness of induction of labor for postterm pregnancy. Am J Obstet Gynecol. 1995 Jan; 172(1 Pt 1):240-1. PMID: 7847550.
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    186. Hillers TK, Guyatt GH, Oldridge N, Crowe J, Willan A, Griffith L, Feeny D. Quality of life after myocardial infarction. J Clin Epidemiol. 1994 Nov; 47(11):1287-96. PMID: 7722565.
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    187. Gilbert R, Willan AR, Richardson S, Sellick S. Survey of family physicians: what is their role in cancer patient care? Can J Oncol. 1994 Jul; 4(3):285-90. PMID: 7529630.
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    188. Willan AR. Power function arguments in support of an alternative approach for analyzing management trials. Control Clin Trials. 1994 Jun; 15(3):211-9. PMID: 8039406.
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    189. Jaeschke R, Guyatt GH, Willan A, Cook D, Harper S, Morris J, Ramsdale H, Haddon R, Newhouse M. Effect of increasing doses of beta agonists on spirometric parameters, exercise capacity, and quality of life in patients with chronic airflow limitation. Thorax. 1994 May; 49(5):479-84. PMID: 8016770; PMCID: PMC474870.
    190. Haynes RB, Walker CJ, McKibbon KA, Johnston ME, Willan AR. Performances of 27 MEDLINE systems tested by searches with clinical questions. J Am Med Inform Assoc. 1994 May-Jun; 1(3):285-95. PMID: 7719810; PMCID: PMC116206.
    191. O'Brien BJ, Drummond MF, Labelle RJ, Willan A. In search of power and significance: issues in the design and analysis of stochastic cost-effectiveness studies in health care. Med Care. 1994 Feb; 32(2):150-63. PMID: 8302107.
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    192. Collins JA, Burrows EA, Willan AR. Occupation and the clinical characteristics of infertile couples. Can J Public Health. 1994 Jan-Feb; 85(1):28-32. PMID: 8180920.
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    193. Juniper EF, Guyatt GH, Willan A, Griffith LE. Determining a minimal important change in a disease-specific Quality of Life Questionnaire. J Clin Epidemiol. 1994 Jan; 47(1):81-7. PMID: 8283197.
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    194. Guyatt GH, Eagle DJ, Sackett B, Willan A, Griffith L, McIlroy W, Patterson CJ, Turpie I. Measuring quality of life in the frail elderly. J Clin Epidemiol. 1993 Dec; 46(12):1433-44. PMID: 8263570.
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    195. Guyatt GH, Nishikawa J, Willan A, McIlroy W, Cook D, Gibson J, Kerigan A, Neville A. A measurement process for evaluating clinical teachers in internal medicine. CMAJ. 1993 Oct 15; 149(8):1097-102. PMID: 8221448; PMCID: PMC1485472.
    196. Collins JA, Burrows EA, Willan AR. Occupation and the follow-up of infertile couples. Fertil Steril. 1993 Sep; 60(3):477-85. PMID: 8375530.
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    197. Molloy DW, Guyatt GH, Standish T, Willan A, McIlroy W, D'Souza J, Brown G, Mondadori C. Effect of a new nootropic agent, CGS 5649B, on cognition, function, and behavior in dementia. J Gen Intern Med. 1993 Aug; 8(8):444-7. PMID: 8410411.
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    198. Jaeschke R, Guyatt GH, Cook D, Morris J, Willan A, McIlroy W, Harper S, Ramsdale H, Haddon R, Fitzgerald MJ, et al. The effect of increasing doses of beta-agonists on airflow in patients with chronic airflow limitation. Respir Med. 1993 Aug; 87(6):433-8. PMID: 8105519.
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    199. Cook DJ, Guyatt GH, Ryan G, Clifton J, Buckingham L, Willan A, McIlroy W, Oxman AD. Should unpublished data be included in meta-analyses? Current convictions and controversies. JAMA. 1993 Jun 02; 269(21):2749-53. PMID: 8492400.
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    200. Cook DJ, Guyatt GH, Juniper E, Griffith L, McIlroy W, Willan A, Jaeschke R, Epstein R. Interviewer versus self-administered questionnaires in developing a disease-specific, health-related quality of life instrument for asthma. J Clin Epidemiol. 1993 Jun; 46(6):529-34. PMID: 8501479.
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    201. Haynes RB, Johnston ME, McKibbon KA, Walker CJ, Willan AR. A program to enhance clinical use of MEDLINE. A randomized controlled trial. Online J Curr Clin Trials. 1993 May 11; Doc No 56:[4005 words; 39 paragraphs]. PMID: 8306006.
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    202. Cook DJ, Guyatt GH, Davis C, Willan A, McIlroy W. A diagnostic and therapeutic N-of-1 randomized trial. Can J Psychiatry. 1993 May; 38(4):251-4. PMID: 8518976.
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    203. Rosenbaum P, Gowland C, King G, King S, Law M, Russell D, Willan A. Toronto clinic's new approach. CMAJ. 1993 Apr 15; 148(8):1270, 1272; author reply 1275. PMID: 8462041; PMCID: PMC1491726.
    204. Willan AR, Ross W, Mackenzie TA. Comparing in-patient classification systems: a problem of non-nested regression models. Stat Med. 1992 Jul; 11(10):1321-31. PMID: 1518993.
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    205. Hannah ME, Hannah WJ, Hellmann J, Hewson S, Milner R, Willan A. Induction of labor as compared with serial antenatal monitoring in post-term pregnancy. A randomized controlled trial. The Canadian Multicenter Post-term Pregnancy Trial Group. N Engl J Med. 1992 Jun 11; 326(24):1587-92. PMID: 1584259.
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    206. Guyatt GH, Oxman AD, Ali M, Willan A, McIlroy W, Patterson C. Laboratory diagnosis of iron-deficiency anemia: an overview. J Gen Intern Med. 1992 Mar-Apr; 7(2):145-53. PMID: 1487761.
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    207. Molloy DW, Guyatt GH, Alemayehu E, McIlroy W, Willan A, Eisemann M, Abraham G, Basile J, Penington G, McMurdo ME, et al. Factors affecting physicians' decisions on caring for an incompetent elderly patient: an international study. CMAJ. 1991 Oct 15; 145(8):947-52. PMID: 1913428; PMCID: PMC1335983.
    208. Warr D, Willan A, Fine S, Wilson K, Davis A, Erlichman C, Rusthoven J, Lofters W, Osoba D, Laberge F, et al. Superiority of granisetron to dexamethasone plus prochlorperazine in the prevention of chemotherapy-induced emesis. J Natl Cancer Inst. 1991 Aug 21; 83(16):1169-73. PMID: 1653363.
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    209. Quirt IC, Shelley WE, Pater JL, Bodurtha AJ, McCulloch PB, McPherson TA, Paterson AH, Prentice R, Silver HK, Willan AR, et al. Improved survival in patients with poor-prognosis malignant melanoma treated with adjuvant levamisole: a phase III study by the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 1991 May; 9(5):729-35. PMID: 2016615.
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    210. MacKenzie TA, Willan AR, Cox MA, Green A. Indirect costs of teaching in Canadian hospitals. CMAJ. 1991 Jan 15; 144(2):149-52. PMID: 1898870; PMCID: PMC1453017.
    211. Anderson JE, Willan AR. Estimating the size of family practice populations. Quadratic Odds Estimation. Med Care. 1988 Dec; 26(12):1228-33. PMID: 3199916.
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    212. Osoba D, Erlichman C, Willan AR, Brigden ML, Geggie P, Pater JL, Rusthoven JJ, Wilson KS. Failure of methylprednisolone acetate to prolong the antinauseant effect of intravenous methylprednisolone sodium succinate in patients receiving chemotherapy. Clin Invest Med. 1988 Oct; 11(5):377-9. PMID: 3052974.
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    213. Ryan CA, Willan AR, Wherrett BA. Home nebulizers in childhood asthma. Parental perceptions and practices. Clin Pediatr (Phila). 1988 Sep; 27(9):420-4. PMID: 2970909.
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    214. Rapp E, Pater JL, Willan A, Cormier Y, Murray N, Evans WK, Hodson DI, Clark DA, Feld R, Arnold AM, et al. Chemotherapy can prolong survival in patients with advanced non-small-cell lung cancer--report of a Canadian multicenter randomized trial. J Clin Oncol. 1988 Apr; 6(4):633-41. PMID: 2833577.
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    215. Shelley WE, Carmichael JC, Brown LB, Fraser RC, Kirk ME, Krepart GV, Levitt M, Roy M, Willan AR, Wilson KS. Adriamycin and cisplatin in the treatment of stage III and IV epithelial ovarian carcinoma. Gynecol Oncol. 1988 Feb; 29(2):208-21. PMID: 3338672.
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    216. Belch A, Shelley W, Bergsagel D, Wilson K, Klimo P, White D, Willan A. A randomized trial of maintenance versus no maintenance melphalan and prednisone in responding multiple myeloma patients. Br J Cancer. 1988 Jan; 57(1):94-9. PMID: 3279997; PMCID: PMC2246700.
    217. Wilson K, Shelley W, Belch A, Brandes L, Bergsagel D, Klimo P, White D, Willan A. Weekly cyclophosphamide and alternate-day prednisone: an effective secondary therapy in multiple myeloma. Cancer Treat Rep. 1987 Oct; 71(10):981-2. PMID: 3652060.
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    218. Evans WK, Feld R, Murray N, Willan A, Coy P, Osoba D, Shepherd FA, Clark DA, Levitt M, MacDonald A, et al. Superiority of alternating non-cross-resistant chemotherapy in extensive small cell lung cancer. A multicenter, randomized clinical trial by the National Cancer Institute of Canada. Ann Intern Med. 1987 Oct; 107(4):451-8. PMID: 2820289.
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    219. Carmichael JA, Shelley WE, Brown LB, Fraser RC, Kirk ME, Krepart GV, Levitt M, Roy M, Willan AR, Wilson KS. A predictive index of cure versus no cure in advanced ovarian carcinoma patients--replacement of second-look laparotomy as a diagnostic test. Gynecol Oncol. 1987 Jul; 27(3):269-81. PMID: 3623227.
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    220. Osoba D, Erlichman C, Willan AR, Levitt M, Pater JL. Superiority of methylprednisolone sodium succinate over low dose metoclopramide hydrochloride in the prevention of nausea and vomiting produced by cancer chemotherapy. Clin Invest Med. 1986 Nov; 9(4):225-31. PMID: 3542325.
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    221. Willan AR, Pater JL. Carryover and the two-period crossover clinical trial. Biometrics. 1986 Sep; 42(3):593-9. PMID: 3567292.
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    222. Anderson JE, Willan AR, Gancher WA. The negative binomial model and the denominator problem in a rural family practice. Fam Pract. 1986 Sep; 3(3):174-83. PMID: 3770338.
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    223. Evans WK, Feld R, Murray N, Pater J, Shelley W, Willan A, Osoba D, Levitt M, Coy P, Hodson I, et al. The use of VP-16 plus cisplatin during induction chemotherapy for small-cell lung cancer. Semin Oncol. 1986 Sep; 13(3 Suppl 3):10-6. PMID: 3020692.
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    224. Rhedda A, McCans J, Willan AR, Ford PM. A double blind placebo controlled crossover randomized trial of diltiazem in Raynaud's phenomenon. J Rheumatol. 1985 Aug; 12(4):724-7. PMID: 3903157.
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    225. Willan AR, Pater JL. Hypothesis testing and sample size for bivariate binomial response in the comparison of two groups. J Chronic Dis. 1985; 38(7):603-8. PMID: 4008602.
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    226. Fried PA, Watkinson B, Willan A. Marijuana use during pregnancy and decreased length of gestation. Am J Obstet Gynecol. 1984 Sep 01; 150(1):23-7. PMID: 6332536.
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    227. Pater JL, Willan AR. Clinical trials as diagnostic tests. Control Clin Trials. 1984 Jun; 5(2):107-13. PMID: 6744884.
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    228. Pater JL, Willan AR. Methodologic issues in trials of antiemetics. J Clin Oncol. 1984 May; 2(5):484-7. PMID: 6726300.
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